WO2000046589A1 - Detection par resonance plasmonique de surface - Google Patents
Detection par resonance plasmonique de surface Download PDFInfo
- Publication number
- WO2000046589A1 WO2000046589A1 PCT/DK2000/000036 DK0000036W WO0046589A1 WO 2000046589 A1 WO2000046589 A1 WO 2000046589A1 DK 0000036 W DK0000036 W DK 0000036W WO 0046589 A1 WO0046589 A1 WO 0046589A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optical
- light beam
- plasmon resonance
- surface plasmon
- unit
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
Definitions
- SPs Surface plasmons
- a commercial SPR system from the company BIAcore is based on a Kretchmann configuration, but where the SPR metal film is disposed on a replaceable glass plate which is physically separated from a glass prism by means of a refractive index matching gel disposed in between the glass prism and the glass plate.
- This instrument is large and expensive and there has been much effort in the art to provide small and compact SPR sensors.
- EP 0 797 090 all mirrors, the sensing layer, the photo-detector array and optionally the light source are integrated in the same house.
- a disadvantage of this configuration is the fact that all components have to be replaced when replacing the sensing layer.
- Optional configurations have been described in EP 0 797 091 , where a transparent base housing and a detachable prism-like optical housing are index matched to avoid undesirable refraction of the light rays. This is performed using index matching gel between the base housing and the optical housing or fabricating concave portions in the base housing and complementary convex portions in the optical housing at the intersections between the two housings. Both options seem to be complicated solutions for practical working SPR sensors.
- said second unit comprises:
- - detecting means being adapted to detect the optical light beam received from the first unit
- the input and output means of the first and second units may comprise antireflecting coatings.
- the detecting means may comprise an array of photosensitive elements, such as a multiple photo detector array, a charge coupled device or a complementary metal oxide semiconductor image sensor.
- the sensor may further comprise a light shield member.
- the first set of optical elements of the first unit may comprise a diffractive member, such as a diffractive grating or a holographic grating.
- the second set of optical elements of the first unit may comprise a diffractive member, such as a diffractive grating or a holographic grating.
- the diffractive members may be formed by reflective members.
- the second set of optical elements may also comprise a reflective member, such as a reflective mirror.
- - detecting means being adapted to detect the received optical light beam from the first unit
- propagation directions of the optical light beams at the positions of the optical input and optical output means are essentially perpendicular to the exterior surface parts of the second housing so as to avoid refraction of the optical light beams at the positions of the optical input and optical output means.
- the second unit may further comprise an optical element being adapted to direct the received optical light beam from the first unit towards the detecting means.
- the light emitting means may comprise light sources as described in relation to the first aspect of the present invention.
- the set of optical elements of the second unit may comprise collimating and/or polarizing means as described in accordance with the first aspect of the present invention.
- a first optical grating being held by a first exterior surface part of the member and being adapted to direct a received optical light beam towards the electrically conducting layer, wherein the propagation direction of the received optical light beam at the position of the first optical grating is essentially perpendicular to the first exterior surface part of the member and wherein the received optical light beam is collimated, and
- a second optical grating being held by a second exterior surface part of the member and being adapted to receive an optical light beam from the electrically conducting layer and being adapted to re-emit the optical light beam received from the electrically conducting layer, wherein the propagation direction of the re- emitted optical light beam at the position of the second optical grating is essen- tially perpendicular to the second exterior surface part of the member and wherein the re-emitted optical light beam is collimated.
- a replaceable sensor chip constructed of laterally integrated arrays of planar sensor chip units (SCUs), and
- the present invention covers configurations, where the light beam propagating in the SCU is either focused on the SPR metal film as in Figs. 2(a), (b) and (e), or the light beam propagating in the SCU is focused in between the first set of optical elements and the second set of optical elements as in Fig. 2(d), or the light beam propagating in the SCU is collimated as in Fig. 2(c).
- the first and the second set of optical elements are mirrors (cylindrical parabolic mirrors) or reflective diffractive optical elements (RDOE) .
- the first and the second set of optical elements are lenses, microlens arrays or transmission diffractive optical elements.
- the light beam is subsequently reflected and focused onto a line on a SPR metal film (20) underneath one or more sensing areas (21 ) on the top.
- the focused light beam comprises angular bands covering the SPR angle.
- the light beam is reflected from the flat mirror ( 1 9) .
- Via a second RDOE (22a) it is transformed into a collimated light beam again, which exits the SCU perpendicularly to the backside surface of the SCU and reenters the OTU perpendicularly to the transparent separation plane ( 1 7).
- a flat mirror (24) mounted in the base plane combined with a flat mirror (25) mounted in the center of the transparent separation plane images the collimated light beam onto a detector array (23).
- the mirrors (24) and (25) can be omitted or they can be replaced by other optical means such as a lens system.
- CMOS image sensor e.g. a Hamamatsu S3921 -128Q, F with an array of 1 28 pixels
- charge coupled device arrays e.g. a SONY ICX059CL with an array of 795x596 pixels
- a complementary metal oxide semiconductor image sensor e.g. Vision VV5404 integrated 356x292 pixel monochrome CMOS image sensor
- Fig 4 illustrates two other embodiments of the present invention, each with a SCU and the corresponding OTU separated by a gap.
- the second embodiment of the in- vention in Fig.4(a) comprises a SCU as depicted in Fig. 2(c), but with an additional reflective mirror disposed on the backside surface of the SCU, and an OTU where the light source ( 14) is a white light source (e.g. a white LED lamp from Nichia Chemical Industries, Ltd).
- the flat mirror (25) according to the first embodiment of the invention has been replaced by a diffraction grating or a holographic grating.
- the SPR angle is kept constant and the detector array (23) measures the wavelength of light corresponding to wave vector matching of the light and the SP.
- the grating (25) diffracts the light and images the light on different pixels in the detector array according to the wavelength of light.
- the RDOEs ( 1 8a) and (22a) are now designed to exhibit minimum wavelength dependent deflection angle and they reflect the colli- mated light beam into a collimated light beam inside the sensor chip unit.
- a fifth embodiment of the present invention is depicted. It comprises the same components in the SCU and in the OTU as depicted in Fig. 4, but the first light source and the second light source are now disposed symmetrically in relation to the sensing layers.
- the SCU comprises a plane mirror (40) on the topside surface and the OTU comprises the plane mirrors (24), (25) and (29) which serve to direct the first light beam and the second light beam towards the detector array (23).
- the function of this grating is the same as in Fig. 9, but the configuration employs a second grating angle rather than vertical grating walls.
- the RDOEs can be made using various processing techniques in transparent materials for the wavelength of light like polymers (e.g. polycarbonate, polystyrene, poly- etherimide or polyurethane resin), glass (e.g. SF2, SF5, SF1 1 or sapphire) or silicon and combining them with metal evaporation or sputtering.
- Polymers e.g. polycarbonate, polystyrene, poly- etherimide or polyurethane resin
- glass e.g. SF2, SF5, SF1 1 or sapphire
- silicon e.g. SF2, SF5, SF1 1 or sapphire
- Plastic usually exhibits birefringence, but the polarization of the light beam can be tuned to match the TM mode of the surface plasmon by means of a polarizer.
- the possible processing techniques includes one-level gray-tone lithography, diamond turning, photolithographic binary optics, e-beam writing, laser micromechanical etching, and analogue or digital holographic writing in photoresist
- the processing techniques can be employed either directly in processing the sensor chip or in the fabrication of a mould for the sensor chip.
- ⁇ is the wavelength of light
- rn is the diffraction order
- L p and 2h are the horizontal and vertical distances between the focal point of the grating and the position of the p'th grating element, respectively [see Figs. 9(b) and 10(b)].
- the angular bands covered by the SPR has typically a full width half maximum (FWHM) in the reflectivity vs. angular spectrum of ⁇ ⁇ 1 °-3°.
- FWHM full width half maximum
- MREs antibodies/antigens and the present SPR sensor could be employed as a label-free immunosensor based on antibody/antigen reactions to determine specific analytes.
- Antibodies can readily be immobilized in a hydrogel through covalent binding.
- the Biosensor group from BIAcore has used antibodies immobilized in a carboxymethyl-dextran hydrogel membrane on the gold film of a SPR sensor for detecting various biological compounds.
- An alternative to antibody/antigen reactions is the utilization of molecular imprinting techniques, where synthetic polymers possess selective molecular recognition properties. This is due to the self-assembled or preorganized positioning of functional groups which generate recognition sites within a polymer membrane that are complementary to the shape and the functional groups of the analyte.
- a second alternative is the use of oligonucleotide ligands, which may provide specific and high affinity binding with specific analytes.
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU22785/00A AU771594B2 (en) | 1999-02-01 | 2000-01-28 | A surface plasmon resonance sensor |
JP2000597621A JP2002536638A (ja) | 1999-02-01 | 2000-01-28 | 表面プラズモン共鳴センサ |
EP00901485A EP1157266A1 (fr) | 1999-02-01 | 2000-01-28 | Detection par resonance plasmonique de surface |
CA002360932A CA2360932A1 (fr) | 1999-02-01 | 2000-01-28 | Detection par resonance plasmonique de surface |
NZ513843A NZ513843A (en) | 1999-02-01 | 2000-01-28 | A surface plasmon resonance sensor |
KR1020017009709A KR20010110428A (ko) | 1999-02-01 | 2000-01-28 | 표면 플라즈몬 공진 센서 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11811199P | 1999-02-01 | 1999-02-01 | |
DKPA199900118 | 1999-02-01 | ||
US60/118,111 | 1999-02-01 | ||
DKPA199900118 | 1999-02-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000046589A1 true WO2000046589A1 (fr) | 2000-08-10 |
Family
ID=26063351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2000/000036 WO2000046589A1 (fr) | 1999-02-01 | 2000-01-28 | Detection par resonance plasmonique de surface |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1157266A1 (fr) |
JP (1) | JP2002536638A (fr) |
KR (1) | KR20010110428A (fr) |
CN (1) | CN1344366A (fr) |
AU (1) | AU771594B2 (fr) |
CA (1) | CA2360932A1 (fr) |
NZ (1) | NZ513843A (fr) |
WO (1) | WO2000046589A1 (fr) |
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WO2002066162A1 (fr) * | 2001-02-16 | 2002-08-29 | Vir A/S | Procede de preparation de dispositifs de detection optique (bio)chimiques |
JP2002296176A (ja) * | 2001-01-25 | 2002-10-09 | Fuji Photo Film Co Ltd | 全反射減衰を利用したセンサー |
JP2002357544A (ja) * | 2001-03-27 | 2002-12-13 | Fuji Photo Film Co Ltd | 測定装置 |
WO2003034046A1 (fr) * | 2001-10-17 | 2003-04-24 | Vir A/S | Capteur base sur la resonance des plasmons de surface |
NL1019317C2 (nl) * | 2001-11-06 | 2003-05-07 | Tno | Detectie van een geladen deeltje. |
WO2003056308A1 (fr) | 2001-12-21 | 2003-07-10 | Erk Gedig | Dispositif et procede d'examen de couches minces |
US6646744B2 (en) | 2000-07-21 | 2003-11-11 | Vir A/S | Coupling elements for surface plasmon resonance sensors |
WO2003102559A1 (fr) * | 2002-05-31 | 2003-12-11 | Gyros Ab | Agencement detecteur utilisant une resonance plasmonique de surface |
WO2004046681A2 (fr) * | 2002-11-18 | 2004-06-03 | Vir A/S | Biocapteur de compensation de dispersion |
NL1022916C2 (nl) * | 2003-03-13 | 2004-09-14 | Ssens B V | Toestel en werkwijze voor onderzoek van een dunne laag opbouw gebruik makend van oppervlakte plasmon resonantie en inrichting en werkwijze voor het regelen van temperatuur. |
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WO2006030957A1 (fr) * | 2004-09-16 | 2006-03-23 | Canon Kabushiki Kaisha | Dispositif et procede pour acquerir des informations sur la substance d'un objectif a detecter en captant une variation des caracteristiques de longueur d'onde sur la transmittance optique |
EP1711798A2 (fr) * | 2003-10-16 | 2006-10-18 | Advanced Fluidix Laboratories, LLC | Ensemble optique a multiples lentilles pour dispositif de diagnostic |
EP1835277A1 (fr) | 2006-03-15 | 2007-09-19 | Omron Corporation | Composant optique, capteur optique, capteur de plasmons de surface et dispositif de reconnaissance d'empreintes digitales |
WO2008060172A1 (fr) * | 2006-11-15 | 2008-05-22 | Biosurfit, S.A. | Dispositif de détection dynamique basé sur un effet de résonance plasmonique de surface |
EP2030029A2 (fr) * | 2006-05-31 | 2009-03-04 | Lockheed Martin Corporation | Procédé et appareil pour détecter l'énergie électromagnétique à l'aide de polaritons de plasmon de surface |
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EP0797091A1 (fr) * | 1996-03-19 | 1997-09-24 | Texas Instruments Incorporated | Capteur à resonance de plasmon de surface avec element optique remplacable |
EP0863395A2 (fr) * | 1997-02-07 | 1998-09-09 | Fuji Photo Film Co., Ltd. | Capteur de plasmons de surface |
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-
2000
- 2000-01-28 WO PCT/DK2000/000036 patent/WO2000046589A1/fr not_active Application Discontinuation
- 2000-01-28 AU AU22785/00A patent/AU771594B2/en not_active Ceased
- 2000-01-28 EP EP00901485A patent/EP1157266A1/fr not_active Withdrawn
- 2000-01-28 CN CN00805379A patent/CN1344366A/zh active Pending
- 2000-01-28 NZ NZ513843A patent/NZ513843A/en unknown
- 2000-01-28 CA CA002360932A patent/CA2360932A1/fr not_active Abandoned
- 2000-01-28 JP JP2000597621A patent/JP2002536638A/ja active Pending
- 2000-01-28 KR KR1020017009709A patent/KR20010110428A/ko not_active Application Discontinuation
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WO1990005295A1 (fr) * | 1988-11-10 | 1990-05-17 | Pharmacia Ab | Systeme de biocapteur optique |
US5822073A (en) * | 1995-10-25 | 1998-10-13 | University Of Washington | Optical lightpipe sensor based on surface plasmon resonance |
EP0797091A1 (fr) * | 1996-03-19 | 1997-09-24 | Texas Instruments Incorporated | Capteur à resonance de plasmon de surface avec element optique remplacable |
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Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6646744B2 (en) | 2000-07-21 | 2003-11-11 | Vir A/S | Coupling elements for surface plasmon resonance sensors |
JP2002296176A (ja) * | 2001-01-25 | 2002-10-09 | Fuji Photo Film Co Ltd | 全反射減衰を利用したセンサー |
WO2002066162A1 (fr) * | 2001-02-16 | 2002-08-29 | Vir A/S | Procede de preparation de dispositifs de detection optique (bio)chimiques |
JP2002357544A (ja) * | 2001-03-27 | 2002-12-13 | Fuji Photo Film Co Ltd | 測定装置 |
DE10151312C2 (de) * | 2001-10-17 | 2003-08-28 | Vir As Taastrup | Oberflächenplasmonen-Resonanz-Sensor |
WO2003034046A1 (fr) * | 2001-10-17 | 2003-04-24 | Vir A/S | Capteur base sur la resonance des plasmons de surface |
DE10151312A1 (de) * | 2001-10-17 | 2003-05-08 | Vir As Taastrup | Oberflächenplasmonen-Resonanz-Sensor |
NL1019317C2 (nl) * | 2001-11-06 | 2003-05-07 | Tno | Detectie van een geladen deeltje. |
DE10163657A1 (de) * | 2001-12-21 | 2003-07-10 | Erk Gedig | Vorrichtung und Verfahren zur Untersuchung dünner Schichten |
WO2003056308A1 (fr) | 2001-12-21 | 2003-07-10 | Erk Gedig | Dispositif et procede d'examen de couches minces |
DE10163657B4 (de) * | 2001-12-21 | 2008-05-08 | Gedig, Erk, Dr. | Vorrichtung und Verfahren zur Untersuchung dünner Schichten |
WO2003102559A1 (fr) * | 2002-05-31 | 2003-12-11 | Gyros Ab | Agencement detecteur utilisant une resonance plasmonique de surface |
US7295320B2 (en) | 2002-05-31 | 2007-11-13 | Gyros Ab | Detector arrangement based on surfaces plasmon resonance |
WO2004046681A2 (fr) * | 2002-11-18 | 2004-06-03 | Vir A/S | Biocapteur de compensation de dispersion |
WO2004046681A3 (fr) * | 2002-11-18 | 2004-08-05 | Vir As | Biocapteur de compensation de dispersion |
NL1022916C2 (nl) * | 2003-03-13 | 2004-09-14 | Ssens B V | Toestel en werkwijze voor onderzoek van een dunne laag opbouw gebruik makend van oppervlakte plasmon resonantie en inrichting en werkwijze voor het regelen van temperatuur. |
DE10324973B4 (de) * | 2003-05-27 | 2006-04-13 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Anordnung und Verfahren zur optischen Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln |
DE10324973A1 (de) * | 2003-05-27 | 2004-12-30 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Anordnung und Verfahren zur optischen Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln |
EP1711798A2 (fr) * | 2003-10-16 | 2006-10-18 | Advanced Fluidix Laboratories, LLC | Ensemble optique a multiples lentilles pour dispositif de diagnostic |
EP1711798A4 (fr) * | 2003-10-16 | 2008-12-03 | Advanced Fluidix Lab Llc | Ensemble optique a multiples lentilles pour dispositif de diagnostic |
US7701582B2 (en) | 2003-11-19 | 2010-04-20 | Beanor Oy | Method and device for carrying out surface plasmon resonance measurement |
US7944564B2 (en) | 2004-09-16 | 2011-05-17 | Canon Kabushiki Kaisha | Device and method for acquiring information on objective substance to be detected by detecting a change of wavelength characteristics on the optical transmittance |
WO2006030957A1 (fr) * | 2004-09-16 | 2006-03-23 | Canon Kabushiki Kaisha | Dispositif et procede pour acquerir des informations sur la substance d'un objectif a detecter en captant une variation des caracteristiques de longueur d'onde sur la transmittance optique |
US7659987B2 (en) | 2004-09-16 | 2010-02-09 | Canon Kabushiki Kaisha | Device and method for acquiring information on objective substance to be detected by detecting a change of wavelength characteristics on the optical transmittance |
EP1835277A1 (fr) | 2006-03-15 | 2007-09-19 | Omron Corporation | Composant optique, capteur optique, capteur de plasmons de surface et dispositif de reconnaissance d'empreintes digitales |
US7692795B2 (en) | 2006-03-15 | 2010-04-06 | Omron Corporation | Optical component, optical sensor, surface plasmon sensor and fingerprint recognition device |
EP2030029A2 (fr) * | 2006-05-31 | 2009-03-04 | Lockheed Martin Corporation | Procédé et appareil pour détecter l'énergie électromagnétique à l'aide de polaritons de plasmon de surface |
EP2030029A4 (fr) * | 2006-05-31 | 2011-01-26 | Lockheed Corp | Procédé et appareil pour détecter l'énergie électromagnétique à l'aide de polaritons de plasmon de surface |
WO2008060172A1 (fr) * | 2006-11-15 | 2008-05-22 | Biosurfit, S.A. | Dispositif de détection dynamique basé sur un effet de résonance plasmonique de surface |
US8149412B2 (en) | 2006-11-15 | 2012-04-03 | Biosurfit, S.A. | Dynamic detection device based on surface plasmon resonance effect |
WO2011058308A1 (fr) * | 2009-11-11 | 2011-05-19 | Millipore Corporation | Capteur optique |
US9316579B2 (en) | 2009-11-11 | 2016-04-19 | Emd Millipore Corporation | Method and apparatus for optical sensing using an optical sensor including a leaky mode waveguide |
WO2022002991A1 (fr) * | 2020-06-30 | 2022-01-06 | Ams International Ag | Appareil de résonance plasmonique de surface d'imagerie |
US11486825B1 (en) * | 2022-06-07 | 2022-11-01 | The Florida International University Board Of Trustees | Devices and methods for analysis of biological matter using plasmon resonance |
Also Published As
Publication number | Publication date |
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AU2278500A (en) | 2000-08-25 |
CA2360932A1 (fr) | 2000-08-10 |
KR20010110428A (ko) | 2001-12-13 |
NZ513843A (en) | 2002-07-26 |
EP1157266A1 (fr) | 2001-11-28 |
JP2002536638A (ja) | 2002-10-29 |
CN1344366A (zh) | 2002-04-10 |
AU771594B2 (en) | 2004-03-25 |
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