WO2000046589A1 - Detection par resonance plasmonique de surface - Google Patents

Detection par resonance plasmonique de surface Download PDF

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Publication number
WO2000046589A1
WO2000046589A1 PCT/DK2000/000036 DK0000036W WO0046589A1 WO 2000046589 A1 WO2000046589 A1 WO 2000046589A1 DK 0000036 W DK0000036 W DK 0000036W WO 0046589 A1 WO0046589 A1 WO 0046589A1
Authority
WO
WIPO (PCT)
Prior art keywords
optical
light beam
plasmon resonance
surface plasmon
unit
Prior art date
Application number
PCT/DK2000/000036
Other languages
English (en)
Inventor
Carsten Thirstrup
Original Assignee
Vir A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vir A/S filed Critical Vir A/S
Priority to JP2000597621A priority Critical patent/JP2002536638A/ja
Priority to NZ513843A priority patent/NZ513843A/en
Priority to AU22785/00A priority patent/AU771594B2/en
Priority to KR1020017009709A priority patent/KR20010110428A/ko
Priority to EP00901485A priority patent/EP1157266A1/fr
Priority to CA002360932A priority patent/CA2360932A1/fr
Publication of WO2000046589A1 publication Critical patent/WO2000046589A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons

Definitions

  • SPs Surface plasmons
  • a commercial SPR system from the company BIAcore is based on a Kretchmann configuration, but where the SPR metal film is disposed on a replaceable glass plate which is physically separated from a glass prism by means of a refractive index matching gel disposed in between the glass prism and the glass plate.
  • This instrument is large and expensive and there has been much effort in the art to provide small and compact SPR sensors.
  • EP 0 797 090 all mirrors, the sensing layer, the photo-detector array and optionally the light source are integrated in the same house.
  • a disadvantage of this configuration is the fact that all components have to be replaced when replacing the sensing layer.
  • Optional configurations have been described in EP 0 797 091 , where a transparent base housing and a detachable prism-like optical housing are index matched to avoid undesirable refraction of the light rays. This is performed using index matching gel between the base housing and the optical housing or fabricating concave portions in the base housing and complementary convex portions in the optical housing at the intersections between the two housings. Both options seem to be complicated solutions for practical working SPR sensors.
  • said second unit comprises:
  • - detecting means being adapted to detect the optical light beam received from the first unit
  • the input and output means of the first and second units may comprise antireflecting coatings.
  • the detecting means may comprise an array of photosensitive elements, such as a multiple photo detector array, a charge coupled device or a complementary metal oxide semiconductor image sensor.
  • the sensor may further comprise a light shield member.
  • the first set of optical elements of the first unit may comprise a diffractive member, such as a diffractive grating or a holographic grating.
  • the second set of optical elements of the first unit may comprise a diffractive member, such as a diffractive grating or a holographic grating.
  • the diffractive members may be formed by reflective members.
  • the second set of optical elements may also comprise a reflective member, such as a reflective mirror.
  • - detecting means being adapted to detect the received optical light beam from the first unit
  • propagation directions of the optical light beams at the positions of the optical input and optical output means are essentially perpendicular to the exterior surface parts of the second housing so as to avoid refraction of the optical light beams at the positions of the optical input and optical output means.
  • the second unit may further comprise an optical element being adapted to direct the received optical light beam from the first unit towards the detecting means.
  • the light emitting means may comprise light sources as described in relation to the first aspect of the present invention.
  • the set of optical elements of the second unit may comprise collimating and/or polarizing means as described in accordance with the first aspect of the present invention.
  • a first optical grating being held by a first exterior surface part of the member and being adapted to direct a received optical light beam towards the electrically conducting layer, wherein the propagation direction of the received optical light beam at the position of the first optical grating is essentially perpendicular to the first exterior surface part of the member and wherein the received optical light beam is collimated, and
  • a second optical grating being held by a second exterior surface part of the member and being adapted to receive an optical light beam from the electrically conducting layer and being adapted to re-emit the optical light beam received from the electrically conducting layer, wherein the propagation direction of the re- emitted optical light beam at the position of the second optical grating is essen- tially perpendicular to the second exterior surface part of the member and wherein the re-emitted optical light beam is collimated.
  • a replaceable sensor chip constructed of laterally integrated arrays of planar sensor chip units (SCUs), and
  • the present invention covers configurations, where the light beam propagating in the SCU is either focused on the SPR metal film as in Figs. 2(a), (b) and (e), or the light beam propagating in the SCU is focused in between the first set of optical elements and the second set of optical elements as in Fig. 2(d), or the light beam propagating in the SCU is collimated as in Fig. 2(c).
  • the first and the second set of optical elements are mirrors (cylindrical parabolic mirrors) or reflective diffractive optical elements (RDOE) .
  • the first and the second set of optical elements are lenses, microlens arrays or transmission diffractive optical elements.
  • the light beam is subsequently reflected and focused onto a line on a SPR metal film (20) underneath one or more sensing areas (21 ) on the top.
  • the focused light beam comprises angular bands covering the SPR angle.
  • the light beam is reflected from the flat mirror ( 1 9) .
  • Via a second RDOE (22a) it is transformed into a collimated light beam again, which exits the SCU perpendicularly to the backside surface of the SCU and reenters the OTU perpendicularly to the transparent separation plane ( 1 7).
  • a flat mirror (24) mounted in the base plane combined with a flat mirror (25) mounted in the center of the transparent separation plane images the collimated light beam onto a detector array (23).
  • the mirrors (24) and (25) can be omitted or they can be replaced by other optical means such as a lens system.
  • CMOS image sensor e.g. a Hamamatsu S3921 -128Q, F with an array of 1 28 pixels
  • charge coupled device arrays e.g. a SONY ICX059CL with an array of 795x596 pixels
  • a complementary metal oxide semiconductor image sensor e.g. Vision VV5404 integrated 356x292 pixel monochrome CMOS image sensor
  • Fig 4 illustrates two other embodiments of the present invention, each with a SCU and the corresponding OTU separated by a gap.
  • the second embodiment of the in- vention in Fig.4(a) comprises a SCU as depicted in Fig. 2(c), but with an additional reflective mirror disposed on the backside surface of the SCU, and an OTU where the light source ( 14) is a white light source (e.g. a white LED lamp from Nichia Chemical Industries, Ltd).
  • the flat mirror (25) according to the first embodiment of the invention has been replaced by a diffraction grating or a holographic grating.
  • the SPR angle is kept constant and the detector array (23) measures the wavelength of light corresponding to wave vector matching of the light and the SP.
  • the grating (25) diffracts the light and images the light on different pixels in the detector array according to the wavelength of light.
  • the RDOEs ( 1 8a) and (22a) are now designed to exhibit minimum wavelength dependent deflection angle and they reflect the colli- mated light beam into a collimated light beam inside the sensor chip unit.
  • a fifth embodiment of the present invention is depicted. It comprises the same components in the SCU and in the OTU as depicted in Fig. 4, but the first light source and the second light source are now disposed symmetrically in relation to the sensing layers.
  • the SCU comprises a plane mirror (40) on the topside surface and the OTU comprises the plane mirrors (24), (25) and (29) which serve to direct the first light beam and the second light beam towards the detector array (23).
  • the function of this grating is the same as in Fig. 9, but the configuration employs a second grating angle rather than vertical grating walls.
  • the RDOEs can be made using various processing techniques in transparent materials for the wavelength of light like polymers (e.g. polycarbonate, polystyrene, poly- etherimide or polyurethane resin), glass (e.g. SF2, SF5, SF1 1 or sapphire) or silicon and combining them with metal evaporation or sputtering.
  • Polymers e.g. polycarbonate, polystyrene, poly- etherimide or polyurethane resin
  • glass e.g. SF2, SF5, SF1 1 or sapphire
  • silicon e.g. SF2, SF5, SF1 1 or sapphire
  • Plastic usually exhibits birefringence, but the polarization of the light beam can be tuned to match the TM mode of the surface plasmon by means of a polarizer.
  • the possible processing techniques includes one-level gray-tone lithography, diamond turning, photolithographic binary optics, e-beam writing, laser micromechanical etching, and analogue or digital holographic writing in photoresist
  • the processing techniques can be employed either directly in processing the sensor chip or in the fabrication of a mould for the sensor chip.
  • ⁇ is the wavelength of light
  • rn is the diffraction order
  • L p and 2h are the horizontal and vertical distances between the focal point of the grating and the position of the p'th grating element, respectively [see Figs. 9(b) and 10(b)].
  • the angular bands covered by the SPR has typically a full width half maximum (FWHM) in the reflectivity vs. angular spectrum of ⁇ ⁇ 1 °-3°.
  • FWHM full width half maximum
  • MREs antibodies/antigens and the present SPR sensor could be employed as a label-free immunosensor based on antibody/antigen reactions to determine specific analytes.
  • Antibodies can readily be immobilized in a hydrogel through covalent binding.
  • the Biosensor group from BIAcore has used antibodies immobilized in a carboxymethyl-dextran hydrogel membrane on the gold film of a SPR sensor for detecting various biological compounds.
  • An alternative to antibody/antigen reactions is the utilization of molecular imprinting techniques, where synthetic polymers possess selective molecular recognition properties. This is due to the self-assembled or preorganized positioning of functional groups which generate recognition sites within a polymer membrane that are complementary to the shape and the functional groups of the analyte.
  • a second alternative is the use of oligonucleotide ligands, which may provide specific and high affinity binding with specific analytes.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne des détecteurs à résonance plasmonique de surface (SPR) comprenant une puce de détection constituée de réseaux intégrés latéralement d'unités de puce de détection plates et un transducteur optique constitué de réseaux intégrés latéralement d'unités de transduction optique plate. Une distance sépare la puce de détection remplaçable du transducteur optique, espace prévu pour y intercaler des interconnexions optiques perpendiculaires. Des éléments optiques de focalisation et de collimation ainsi que des zones de détection sont intégrés sur la même puce de détection tandis que les interconnexions optiques sont basées sur des faisceaux lumineux collimatés qui incident de manière perpendiculaire aux interfaces. Les éléments optiques de focalisation allient un élément optique diffracteur réfléchissant sur la surface supérieure et un miroir plat facultatif sur la surface arrière des unités de puce de détection.
PCT/DK2000/000036 1999-02-01 2000-01-28 Detection par resonance plasmonique de surface WO2000046589A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2000597621A JP2002536638A (ja) 1999-02-01 2000-01-28 表面プラズモン共鳴センサ
NZ513843A NZ513843A (en) 1999-02-01 2000-01-28 A surface plasmon resonance sensor
AU22785/00A AU771594B2 (en) 1999-02-01 2000-01-28 A surface plasmon resonance sensor
KR1020017009709A KR20010110428A (ko) 1999-02-01 2000-01-28 표면 플라즈몬 공진 센서
EP00901485A EP1157266A1 (fr) 1999-02-01 2000-01-28 Detection par resonance plasmonique de surface
CA002360932A CA2360932A1 (fr) 1999-02-01 2000-01-28 Detection par resonance plasmonique de surface

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11811199P 1999-02-01 1999-02-01
US60/118,111 1999-02-01
DKPA199900118 1999-02-01
DKPA199900118 1999-02-01

Publications (1)

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WO2000046589A1 true WO2000046589A1 (fr) 2000-08-10

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EP (1) EP1157266A1 (fr)
JP (1) JP2002536638A (fr)
KR (1) KR20010110428A (fr)
CN (1) CN1344366A (fr)
AU (1) AU771594B2 (fr)
CA (1) CA2360932A1 (fr)
NZ (1) NZ513843A (fr)
WO (1) WO2000046589A1 (fr)

Cited By (20)

* Cited by examiner, † Cited by third party
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WO2002066162A1 (fr) * 2001-02-16 2002-08-29 Vir A/S Procede de preparation de dispositifs de detection optique (bio)chimiques
JP2002296176A (ja) * 2001-01-25 2002-10-09 Fuji Photo Film Co Ltd 全反射減衰を利用したセンサー
JP2002357544A (ja) * 2001-03-27 2002-12-13 Fuji Photo Film Co Ltd 測定装置
WO2003034046A1 (fr) * 2001-10-17 2003-04-24 Vir A/S Capteur base sur la resonance des plasmons de surface
NL1019317C2 (nl) * 2001-11-06 2003-05-07 Tno Detectie van een geladen deeltje.
WO2003056308A1 (fr) 2001-12-21 2003-07-10 Erk Gedig Dispositif et procede d'examen de couches minces
US6646744B2 (en) 2000-07-21 2003-11-11 Vir A/S Coupling elements for surface plasmon resonance sensors
WO2003102559A1 (fr) * 2002-05-31 2003-12-11 Gyros Ab Agencement detecteur utilisant une resonance plasmonique de surface
WO2004046681A2 (fr) * 2002-11-18 2004-06-03 Vir A/S Biocapteur de compensation de dispersion
NL1022916C2 (nl) * 2003-03-13 2004-09-14 Ssens B V Toestel en werkwijze voor onderzoek van een dunne laag opbouw gebruik makend van oppervlakte plasmon resonantie en inrichting en werkwijze voor het regelen van temperatuur.
DE10324973A1 (de) * 2003-05-27 2004-12-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anordnung und Verfahren zur optischen Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln
WO2006030957A1 (fr) * 2004-09-16 2006-03-23 Canon Kabushiki Kaisha Dispositif et procede pour acquerir des informations sur la substance d'un objectif a detecter en captant une variation des caracteristiques de longueur d'onde sur la transmittance optique
EP1711798A2 (fr) * 2003-10-16 2006-10-18 Advanced Fluidix Laboratories, LLC Ensemble optique a multiples lentilles pour dispositif de diagnostic
EP1835277A1 (fr) 2006-03-15 2007-09-19 Omron Corporation Composant optique, capteur optique, capteur de plasmons de surface et dispositif de reconnaissance d'empreintes digitales
WO2008060172A1 (fr) * 2006-11-15 2008-05-22 Biosurfit, S.A. Dispositif de détection dynamique basé sur un effet de résonance plasmonique de surface
EP2030029A2 (fr) * 2006-05-31 2009-03-04 Lockheed Martin Corporation Procédé et appareil pour détecter l'énergie électromagnétique à l'aide de polaritons de plasmon de surface
US7701582B2 (en) 2003-11-19 2010-04-20 Beanor Oy Method and device for carrying out surface plasmon resonance measurement
WO2011058308A1 (fr) * 2009-11-11 2011-05-19 Millipore Corporation Capteur optique
WO2022002991A1 (fr) * 2020-06-30 2022-01-06 Ams International Ag Appareil de résonance plasmonique de surface d'imagerie
US11486825B1 (en) * 2022-06-07 2022-11-01 The Florida International University Board Of Trustees Devices and methods for analysis of biological matter using plasmon resonance

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CN107709974B (zh) 2015-07-07 2020-09-29 古野电气株式会社 测定用芯片、测定装置及测定方法
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Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6646744B2 (en) 2000-07-21 2003-11-11 Vir A/S Coupling elements for surface plasmon resonance sensors
JP2002296176A (ja) * 2001-01-25 2002-10-09 Fuji Photo Film Co Ltd 全反射減衰を利用したセンサー
WO2002066162A1 (fr) * 2001-02-16 2002-08-29 Vir A/S Procede de preparation de dispositifs de detection optique (bio)chimiques
JP2002357544A (ja) * 2001-03-27 2002-12-13 Fuji Photo Film Co Ltd 測定装置
DE10151312C2 (de) * 2001-10-17 2003-08-28 Vir As Taastrup Oberflächenplasmonen-Resonanz-Sensor
WO2003034046A1 (fr) * 2001-10-17 2003-04-24 Vir A/S Capteur base sur la resonance des plasmons de surface
DE10151312A1 (de) * 2001-10-17 2003-05-08 Vir As Taastrup Oberflächenplasmonen-Resonanz-Sensor
NL1019317C2 (nl) * 2001-11-06 2003-05-07 Tno Detectie van een geladen deeltje.
DE10163657A1 (de) * 2001-12-21 2003-07-10 Erk Gedig Vorrichtung und Verfahren zur Untersuchung dünner Schichten
WO2003056308A1 (fr) 2001-12-21 2003-07-10 Erk Gedig Dispositif et procede d'examen de couches minces
DE10163657B4 (de) * 2001-12-21 2008-05-08 Gedig, Erk, Dr. Vorrichtung und Verfahren zur Untersuchung dünner Schichten
WO2003102559A1 (fr) * 2002-05-31 2003-12-11 Gyros Ab Agencement detecteur utilisant une resonance plasmonique de surface
US7295320B2 (en) 2002-05-31 2007-11-13 Gyros Ab Detector arrangement based on surfaces plasmon resonance
WO2004046681A2 (fr) * 2002-11-18 2004-06-03 Vir A/S Biocapteur de compensation de dispersion
WO2004046681A3 (fr) * 2002-11-18 2004-08-05 Vir As Biocapteur de compensation de dispersion
NL1022916C2 (nl) * 2003-03-13 2004-09-14 Ssens B V Toestel en werkwijze voor onderzoek van een dunne laag opbouw gebruik makend van oppervlakte plasmon resonantie en inrichting en werkwijze voor het regelen van temperatuur.
DE10324973B4 (de) * 2003-05-27 2006-04-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anordnung und Verfahren zur optischen Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln
DE10324973A1 (de) * 2003-05-27 2004-12-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anordnung und Verfahren zur optischen Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln
EP1711798A2 (fr) * 2003-10-16 2006-10-18 Advanced Fluidix Laboratories, LLC Ensemble optique a multiples lentilles pour dispositif de diagnostic
EP1711798A4 (fr) * 2003-10-16 2008-12-03 Advanced Fluidix Lab Llc Ensemble optique a multiples lentilles pour dispositif de diagnostic
US7701582B2 (en) 2003-11-19 2010-04-20 Beanor Oy Method and device for carrying out surface plasmon resonance measurement
US7944564B2 (en) 2004-09-16 2011-05-17 Canon Kabushiki Kaisha Device and method for acquiring information on objective substance to be detected by detecting a change of wavelength characteristics on the optical transmittance
WO2006030957A1 (fr) * 2004-09-16 2006-03-23 Canon Kabushiki Kaisha Dispositif et procede pour acquerir des informations sur la substance d'un objectif a detecter en captant une variation des caracteristiques de longueur d'onde sur la transmittance optique
US7659987B2 (en) 2004-09-16 2010-02-09 Canon Kabushiki Kaisha Device and method for acquiring information on objective substance to be detected by detecting a change of wavelength characteristics on the optical transmittance
EP1835277A1 (fr) 2006-03-15 2007-09-19 Omron Corporation Composant optique, capteur optique, capteur de plasmons de surface et dispositif de reconnaissance d'empreintes digitales
US7692795B2 (en) 2006-03-15 2010-04-06 Omron Corporation Optical component, optical sensor, surface plasmon sensor and fingerprint recognition device
EP2030029A2 (fr) * 2006-05-31 2009-03-04 Lockheed Martin Corporation Procédé et appareil pour détecter l'énergie électromagnétique à l'aide de polaritons de plasmon de surface
EP2030029A4 (fr) * 2006-05-31 2011-01-26 Lockheed Corp Procédé et appareil pour détecter l'énergie électromagnétique à l'aide de polaritons de plasmon de surface
WO2008060172A1 (fr) * 2006-11-15 2008-05-22 Biosurfit, S.A. Dispositif de détection dynamique basé sur un effet de résonance plasmonique de surface
US8149412B2 (en) 2006-11-15 2012-04-03 Biosurfit, S.A. Dynamic detection device based on surface plasmon resonance effect
WO2011058308A1 (fr) * 2009-11-11 2011-05-19 Millipore Corporation Capteur optique
US9316579B2 (en) 2009-11-11 2016-04-19 Emd Millipore Corporation Method and apparatus for optical sensing using an optical sensor including a leaky mode waveguide
WO2022002991A1 (fr) * 2020-06-30 2022-01-06 Ams International Ag Appareil de résonance plasmonique de surface d'imagerie
US11486825B1 (en) * 2022-06-07 2022-11-01 The Florida International University Board Of Trustees Devices and methods for analysis of biological matter using plasmon resonance

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AU771594B2 (en) 2004-03-25
CN1344366A (zh) 2002-04-10
JP2002536638A (ja) 2002-10-29
KR20010110428A (ko) 2001-12-13
EP1157266A1 (fr) 2001-11-28
NZ513843A (en) 2002-07-26
AU2278500A (en) 2000-08-25
CA2360932A1 (fr) 2000-08-10

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