WO2000035887A2 - Vitronectin receptor antagonist pharmaceuticals - Google Patents

Vitronectin receptor antagonist pharmaceuticals Download PDF

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Publication number
WO2000035887A2
WO2000035887A2 PCT/US1999/030311 US9930311W WO0035887A2 WO 2000035887 A2 WO2000035887 A2 WO 2000035887A2 US 9930311 W US9930311 W US 9930311W WO 0035887 A2 WO0035887 A2 WO 0035887A2
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
group
independently selected
carbamoyl
bond
Prior art date
Application number
PCT/US1999/030311
Other languages
English (en)
French (fr)
Other versions
WO2000035887A3 (en
Inventor
Edward H Cheesman
Michael Sworin
Milind Rajopadhyem
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Priority to CA002349333A priority Critical patent/CA2349333A1/en
Priority to AU23714/00A priority patent/AU2371400A/en
Priority to EP99967441A priority patent/EP1140864A2/en
Publication of WO2000035887A2 publication Critical patent/WO2000035887A2/en
Publication of WO2000035887A3 publication Critical patent/WO2000035887A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
PCT/US1999/030311 1998-12-18 1999-12-17 Vitronectin receptor antagonist pharmaceuticals WO2000035887A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002349333A CA2349333A1 (en) 1998-12-18 1999-12-17 Vitronectin receptor antagonist pharmaceuticals
AU23714/00A AU2371400A (en) 1998-12-18 1999-12-17 Vitronectin receptor antagonist pharmaceuticals
EP99967441A EP1140864A2 (en) 1998-12-18 1999-12-17 Vitronectin receptor antagonist pharmaceuticals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11283198P 1998-12-18 1998-12-18
US60/112,831 1998-12-18

Publications (2)

Publication Number Publication Date
WO2000035887A2 true WO2000035887A2 (en) 2000-06-22
WO2000035887A3 WO2000035887A3 (en) 2000-11-16

Family

ID=22346057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030311 WO2000035887A2 (en) 1998-12-18 1999-12-17 Vitronectin receptor antagonist pharmaceuticals

Country Status (6)

Country Link
US (2) US6558649B1 (US06818201-20041116-C00086.png)
EP (1) EP1140864A2 (US06818201-20041116-C00086.png)
AU (1) AU2371400A (US06818201-20041116-C00086.png)
CA (1) CA2349333A1 (US06818201-20041116-C00086.png)
TR (1) TR200101757T2 (US06818201-20041116-C00086.png)
WO (1) WO2000035887A2 (US06818201-20041116-C00086.png)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001097861A2 (en) * 2000-06-21 2001-12-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
EP1171166A1 (en) * 1999-04-14 2002-01-16 Diatide, Inc. Benzodiazepine derivatives for imaging thrombi
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
EP1420792A2 (en) * 2001-08-01 2004-05-26 SmithKline Beecham Corporation Products and drug delivery vehicles
WO2004100996A1 (en) * 2003-05-12 2004-11-25 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist compounds and their use in the preparation of radiopharmaceuticals
EP1684809A1 (en) * 2003-09-30 2006-08-02 Semafore Pharmaceuticals, Inc. Chelate based scaffolds in tumor targeting
US7255875B2 (en) 2002-01-24 2007-08-14 Barnes-Jewish Hospital Integrin targeted imaging agents
US7279150B2 (en) 2002-01-24 2007-10-09 Barnes-Jewish Hospital Chelating agents with lipophilic carriers
US7504088B2 (en) 2004-06-09 2009-03-17 Kereos, Inc. Lipophilic derivatives of chelate monoamides
WO2010093706A2 (en) 2009-02-10 2010-08-19 The Scripps Research Institute Chemically programmed vaccination
US7879881B2 (en) 2002-08-16 2011-02-01 Janssen Pharmaceutica Nv Piperidinyl compounds that selectively bind integrins
EP2428226A1 (en) 2001-10-22 2012-03-14 The Scripps Research Institute Antibody targeting compounds

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US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
KR20090014164A (ko) * 2006-04-19 2009-02-06 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 세포 영상화 및 치료를 위한 조성물 및 방법
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
BRPI0915368B1 (pt) 2008-07-03 2019-01-15 Monsanto Technology Llc composição compreendendo glifosato ou um sal ou um ester de glifosato e método de controlar crescimento de planta
US20100178245A1 (en) * 2009-01-13 2010-07-15 Arnsdorf Morton F Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites
FR2977892B1 (fr) 2011-07-13 2013-07-26 Servier Lab Nouveaux agents d'imagerie, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

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Cited By (21)

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Publication number Priority date Publication date Assignee Title
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US7090828B2 (en) 1998-12-18 2006-08-15 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
EP1171166A1 (en) * 1999-04-14 2002-01-16 Diatide, Inc. Benzodiazepine derivatives for imaging thrombi
WO2001097861A3 (en) * 2000-06-21 2003-02-27 Bristol Myers Squibb Pharma Co Vitronectin receptor antagonist pharmaceuticals
WO2001097861A2 (en) * 2000-06-21 2001-12-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
EP1420792A4 (en) * 2001-08-01 2007-10-10 Smithkline Beecham Corp PRODUCTS AND EXCIPIENTS FOR THE ADMINISTRATION OF MEDICAMENTS
EP1420792A2 (en) * 2001-08-01 2004-05-26 SmithKline Beecham Corporation Products and drug delivery vehicles
EP2428226A1 (en) 2001-10-22 2012-03-14 The Scripps Research Institute Antibody targeting compounds
US7727512B2 (en) 2002-01-24 2010-06-01 Barnes-Jewish Hospital Chelating agents with lipophilic carriers
US7279150B2 (en) 2002-01-24 2007-10-09 Barnes-Jewish Hospital Chelating agents with lipophilic carriers
US7255875B2 (en) 2002-01-24 2007-08-14 Barnes-Jewish Hospital Integrin targeted imaging agents
US7344698B2 (en) 2002-01-24 2008-03-18 Barnes-Jewish Hospital Integrin targeted imaging agents
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US6558649B1 (en) 2003-05-06
TR200101757T2 (tr) 2001-12-21
WO2000035887A3 (en) 2000-11-16
US20030143235A1 (en) 2003-07-31
US6818201B2 (en) 2004-11-16
CA2349333A1 (en) 2000-06-22

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