WO2000006185A2 - Procedes d'utilisation d'un analogue de somatostatine - Google Patents

Procedes d'utilisation d'un analogue de somatostatine Download PDF

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Publication number
WO2000006185A2
WO2000006185A2 PCT/US1999/017294 US9917294W WO0006185A2 WO 2000006185 A2 WO2000006185 A2 WO 2000006185A2 US 9917294 W US9917294 W US 9917294W WO 0006185 A2 WO0006185 A2 WO 0006185A2
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WO
WIPO (PCT)
Prior art keywords
disease
cys
syndrome
condition
lanreotide
Prior art date
Application number
PCT/US1999/017294
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English (en)
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WO2000006185A3 (fr
Inventor
Jacques-Pierre Moreau
Original Assignee
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020017001277A priority Critical patent/KR20010071071A/ko
Priority to BR9912609-5A priority patent/BR9912609A/pt
Application filed by Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. filed Critical Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.
Priority to CA002335654A priority patent/CA2335654A1/fr
Priority to EP99937658A priority patent/EP1100532A2/fr
Priority to PL99346361A priority patent/PL346361A1/xx
Priority to NZ509348A priority patent/NZ509348A/xx
Priority to HU0102839A priority patent/HUP0102839A3/hu
Priority to JP2000562039A priority patent/JP2002521456A/ja
Priority to MXPA01000969A priority patent/MXPA01000969A/es
Priority to IL14083799A priority patent/IL140837A0/xx
Priority to AU52447/99A priority patent/AU770193B2/en
Publication of WO2000006185A2 publication Critical patent/WO2000006185A2/fr
Publication of WO2000006185A3 publication Critical patent/WO2000006185A3/fr
Priority to NO20010481A priority patent/NO324123B1/no
Priority to AU2004201783A priority patent/AU2004201783A1/en
Priority to IL181349A priority patent/IL181349A0/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Definitions

  • the present invention is directed to a method of treating one or more of the following diseases and/or conditions in a patient in need thereof, which comprises the administration of the compound of the formula H- ⁇ -D-Nal-Cys- Tyr-D-Trp-Lys-Val-Cys-Thr-NH 2 (also known as lanreotide), where the two Cysteines are bonded by a disulfide bond, or a pharmaceutically acceptable salt thereof, most preferably the acetate salt of the compound, in the treatment of certain diseases and/or conditions such as gastroenterological conditions and/or diseases, such as Crohn's disease, systemic sclerosis, external and internal pancreatic pseudocysts and ascites, VIPoma, nesidoblastosis, hyperinsulinism, gastrinoma, Zollinger-Ellison Syndrome, diarrhea, AIDS related diarrhea, chemotherapy related diarrhea, scleroderma, Irritable Bowel Syndrome, pancreatitis, upper gastrointestinal bleeding, postpra
  • Lanreotide is an analog of somatostatin and is known to inhibit growth hormone release as well as inhibit insulin, glucagon and pancreatic exocrine secretion.
  • U.S. Patent No. 4,853,371 discloses lanreotide, a method for making it and a method for inhibiting the secretion of growth hormone, insulin, glucagon and pancreatic exocrine secretion.
  • U.S. Patent No. 5,147,856 discloses the use of lanreotide of treating restenosis.
  • U.S. Patent No. 5,411 ,943 discloses the use of lanreotide for treating hepatoma.
  • U.S. Patent No. 5,073,541 discloses the use of lanreotide for treating lung cancer.
  • U.S. Application No. 08/089,410 filed July 9, 1993 discloses the use of lanreotide for treating melanoma.
  • U.S. Patent No. 5,504,069 discloses the use of lanreotide for inhibiting the accelerated growth of a solid tumor.
  • U.S. Patent No. 5,688,418 discloses the use of lanreotide for prolonging the survival of pancreatic cells.
  • PCT Application No. PCT/US97/14154 discloses the use of lanreotide for treating fibrosis.
  • This invention is directed to a method of treating a disease or condition which comprises administering to a patient in need thereof an effective amount of the compound H- ⁇ -D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH 2 , where the two Cysteines are bonded by a disulfide bond, or a pharmaceutically acceptable salt thereof, wherein the disease or condition is selected from the group consisting of systemic sclerosis, pancreatic pseudocysts, pancreatic ascites, VIPoma, nesidoblastosis, hyperinsulinism, gastrinoma, Zollinger-Ellison Syndrome, hypersecretory diarrhea, scleroderma, irritable bowel syndrome, upper gastrointestinal bleeding, postprandial portal venous hypertension, complications of portal hypertension, small bowel obstruction, duodenogastric reflux, Cushing's Syndrome, gonadotropinoma, hyperparathyroidism, diabetic neuropathy, macular de
  • a preferred method of the immediately foregoing method is where the acetate salt of H- ⁇ -D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH 2 is administered.
  • a preferred method of the immediately foregoing method is where the disease or condition is selected from the group consisting of VIPoma, nesidoblastosis, hyperinsulinism, gastrinoma, hypersecretory diarrhea, irritable bowel syndrome, upper gastrointestinal bleeding, postprandial portal venous hypertension, especially in cirrhotic patients, complications of portal hypertension, small bowel obstruction, diabetic neuropathy, meningioma and cancer cachexia.
  • a preferred method of the immediately foregoing method is where the disease or condition treated is selected from the group consisting of VIPoma, nesidoblastosis, hypersecretory diarrhea, irritable bowel syndrome, small bowel obstruction and diabetic neuropathy.
  • the present invention is directed to a pharmaceutical composition
  • a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of the acetate salt of H- ⁇ -D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH 2 to treat a disease or condition wherein the disease or condition is selected from the group consisting of systemic sclerosis, pancreatic pseudocysts, pancreatic ascites, VIPoma, nesidoblastosis, hyperinsulinism, gastrinoma, Zollinger-Ellison Syndrome, hypersecretory diarrhea, scleroderma, irritable bowel syndrome, upper gastrointestinal bleeding, postprandial portal venous hypertension, especially in cirrhotic patients, complications of portal hypertension, small bowel obstruction, duodenogastric reflux, Cushing's Syndrome, gonadotropinoma, hyperparathyroidism, diabetic neuropathy, macular degeneration, hypercalcemia of malignancy, Page
  • Lanreotide is readily prepared according to the procedure disclosed in U.S. Patent No. 4,853,371 , or the procedure disclosed in U.S. Patent No. 5,411 ,943, the teachings of which are incorporated herein by reference. Lanreotide is currently marketed as the acetate salt in a 30 mg long-acting form and is available from Ipsen Biotech, Paris, France.
  • somatostatin As is well known to those skilled in the art, the known and potential uses of somatostatin are varied and multitudinous. Somatostatin is known to be useful in the treatment of the diseases and/or conditions listed hereinbelow. The varied uses of somatostatin may be summarized as follows: Cushings Syndrome (see Clark, R.V. et al, Clin. Res. 38, p. 943A, 1990); gonadotropinoma (see Ambrosi B., et al., Acta Endocr. (Copenh.) 122, 569-576, 1990); hyperparathyroidism (see Miller, D., et al., Canad. Med. Ass. J., Vol. 145, pp.
  • Paget's disease see, Palmie , G.M.A., et al., J. of Bone and Mineral Research, 7, (Suppl. 1), p. S240 (Abs. 591 ), 1992
  • VIPoma see Koberstein, B., et al., Z. Gastroenterology, 28, 295-301 , 1990 and Christensen, O, Acta Chir. Scand. 155. 541-543, 1989
  • nesidioblastosis and hyperinsulinism see Laron, Z., Israel J. Med. Sci., 26, No. 1 , 1-2, 1990, Wilson, D.C., Irish J. Med. Sci., 158, No.
  • pancreatitis see Tulassay, Z., et al., Gastroenterology, 98, No. 5, Part 2, Suppl., A238, 1990); Crohn's Disease (see Fedorak, R.N., et al., Can. J. Gastroenterology, 3, No. 2, 53-57, 1989); systemic sclerosis (see Soudah, H., et al., Gastroenterology, 98, No. 5, Part 2, Suppl., A129, 1990); thyroid cancer (see Modigliani, E., et al., Ann., Endocr.
  • pancreatic pseudocysts and ascites see Hartley, J.E., et al., J. Roy. Soc. Med., 85, pp. 107-108, 1992
  • leukemia see Santini, et al., 78, (Suppl. 1), p. 429A (Abs. 1708), 1991
  • meningioma see Koper, J.W., et al., J. Clin. Endocr. Metab., 74, pp. 543-547, 1992
  • cancer cachexia see Bartlett, D.L., et al., Surg. Forum., 42, pp. 14-16, 1991.
  • the contents of the foregoing references are incorporated herein by reference.
  • lanreotide itself was particularly useful in treating the conditions, disorders and disease noted hereinabove.
  • Lanreotide or a pharmaceutically-acceptable salt thereof can be administered by oral, parenteral (e.g., intramuscular, intraperitoneal, intravenous or subcutaneous injection, or implant), nasal, vaginal, rectal, sublingual or topical routes of administration and can be formulated with pharmaceutically acceptable carriers to provide dosage forms appropriate for each route of administration.
  • parenteral e.g., intramuscular, intraperitoneal, intravenous or subcutaneous injection, or implant
  • nasal, vaginal, rectal, sublingual or topical routes of administration can be formulated with pharmaceutically acceptable carriers to provide dosage forms appropriate for each route of administration.
  • Solid dosage forms for oral administration include capsules, tablets, pills, powders and granules.
  • the active compound is admixed with at least one inert pharmaceutically acceptable carrier such as sucrose, lactose, or starch.
  • Such dosage forms can also comprise, as is normal practice, additional substances other than such inert diluents, e.g., lubricating agents such as magnesium stearate.
  • the dosage forms may also comprise buffering agents. Tablets and pills can additionally be prepared with enteric coatings.
  • Liquid dosage forms for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syrups, the elixirs containing inert diluents commonly used in the art, such as water. Besides such inert diluents, compositions can also include adjuvants, such as wetting agents, emulsifying and suspending agents, and sweetening, flavoring and perfuming agents.
  • Preparations according to this invention for parenteral administration include sterile aqueous or non-aqueous solutions, suspensions, or emulsions.
  • non-aqueous solvents or vehicles are propylene glycol, polyethylene glycol, vegetable oils, such as olive oil and corn oil, gelatin, and injectable organic esters such as ethyl oleate.
  • Such dosage forms may also contain adjuvants such as preserving, wetting, emulsifying, and dispersing agents. They may be sterilized by, for example, filtration through a bacteria- retaining filter, by incorporating sterilizing agents into the compositions, by irradiating the compositions, or by heating the compositions. They can also be manufactured in the form of sterile solid compositions which can be dissolved in sterile water, or some other sterile injectable medium immediately before use.
  • compositions for rectal or vaginal administration are preferably suppositories which may contain, in addition to the active substance, excipients such as coca butter or a suppository wax.
  • Compositions for nasal or sublingual administration are also prepared with standard excipients well known in the art.
  • the dosage of active ingredient in the compositions of this invention may be varied; however, it is necessary that the amount of the active ingredient be such that a suitable dosage form is obtained.
  • the selected dosage depends upon the desired therapeutic effect, on the route of administration, and on the duration of the treatment. Generally, dosage levels of between 25 ?g/kg/day to 100 mg/kg/day of body weight daily are administered as a single dose or divided into multiple doses to humans and other animals, e.g., mammals, to obtain the desired therapeutic effect.
  • a preferred general dosage range is 250 ?g/kg/day to 5.0 mg/kg/day of body weight daily which can be administered as a single dose or divided into multiple doses.
  • Lanreotide can be administered in a sustained release composition such as those described in the following patents. Among those formulations, 14-day or 28-day slow release formulations will be preferred.
  • U.S. Patent No. 5,672,659 teaches sustained release compositions comprising Lanreotide and a polyester.
  • U.S. Patent No. 5,595,760 teaches sustained release compositions comprising Lanreotide in a gelable form.
  • U.S. Application No. 08/929,363 filed September 9, 1997 teaches polymeric sustained release compositions comprising Lanreotide and chitosan.
  • U.S. Application No. 08/740,778 filed November 1 , 1996 teaches sustained release compositions comprising Lanreotide and cyclodexthn.
  • U.S. Application No. 09/015,394 filed January 29, 1998 teaches absorbable sustained release compositions of Lanreotide. The contents of the foregoing patents and applications are incorporated herein by reference.
  • immediate or of sustained release compositions depends on the type of indications aimed at. If the indication consists of an acute or over- acute disorder, a treatment with an immediate form will be preferred over the same with a prolonged release composition. On the contrary, for preventive or long-term treatments, a prolonged release composition will generally be preferred.
  • upper gastrointestinal bleeding will correspond an acute or over-acute treatment with a dosage of 80 to 120 ?g/day per person during approximately 5 days.
  • preventive treatment against recurrence can be performed using lanreotide sustained release forms as an adjuvant to usual treatments; for this type of treatment, 14-day sustained release forms with a total dosage of approximately 30 mg lanreotide or 28-day lanreotide forms can be used.

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Abstract

La présente invention concerne un procédé de traitement d'une ou plusieurs des maladies et/ou conditions suivantes. Ce procédé consiste à administrer à un patient le composé H-β-D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2. Les cystéines sont liées par une liaison disulfure ou un sel pharmaceutiquement acceptable de ces dernières, de préférence, le sec acétate du composé, pour traiter certaines maladies et/ou états tels que des conditions et/ou maladies gastroentérologiques, des maladies et/ou des états endocrinologiques, divers types de cancers et états associés à un cancer tel qu'une cachexie de cancer et dans le traitement de l'hypotension et des crises de panique.
PCT/US1999/017294 1998-07-30 1999-07-29 Procedes d'utilisation d'un analogue de somatostatine WO2000006185A2 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
MXPA01000969A MXPA01000969A (es) 1998-07-30 1999-07-29 Metodo de uso de un analogo de somatostatina.
JP2000562039A JP2002521456A (ja) 1998-07-30 1999-07-29 ソマトスタチン類似体の使用法
CA002335654A CA2335654A1 (fr) 1998-07-30 1999-07-29 Procedes d'utilisation d'un analogue de somatostatine
BR9912609-5A BR9912609A (pt) 1998-07-30 1999-07-29 Métodos de uso de um análogo de somatostatina
PL99346361A PL346361A1 (en) 1998-07-30 1999-07-29 Methods of using a somatostatin analogue
NZ509348A NZ509348A (en) 1998-07-30 1999-07-29 Use of a somatostatin analogue Lanreotide
IL14083799A IL140837A0 (en) 1998-07-30 1999-07-29 Method of using lanreotide, a somatostatin analogue
KR1020017001277A KR20010071071A (ko) 1998-07-30 1999-07-29 성장억제 호르몬 유사체의 사용방법
EP99937658A EP1100532A2 (fr) 1998-07-30 1999-07-29 Procedes d'utilisation d'un analogue de somatostatine
HU0102839A HUP0102839A3 (en) 1998-07-30 1999-07-29 Methods of using lanreotide, a somatostatin analogue and pharmaceutical compositions comprising thereof
AU52447/99A AU770193B2 (en) 1998-07-30 1999-07-29 Methods of using a somatostatin analogue
NO20010481A NO324123B1 (no) 1998-07-30 2001-01-29 Anvendelse av lanreotid, eller et farmasoytisk akseptabelt salt derav for fremstilling av et farmasoytisk preparat
AU2004201783A AU2004201783A1 (en) 1998-07-30 2004-04-29 Methods of using a somatostatin analogue
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US6316414B1 (en) 2000-07-31 2001-11-13 Dabur Research Foundation Somatostatin analogs for the treatment of cancer
EP1040837A3 (fr) * 1999-02-26 2002-01-02 Erasmus Universiteit Rotterdam Médicaments pour le traitement des troubles liés à la néovascularisation de lachoroide
WO2002009739A1 (fr) * 2000-07-27 2002-02-07 Novartis Ag Traitement de troubles oculaires au moyen d'analogues de la somatostatine
WO2002083895A2 (fr) * 2001-04-18 2002-10-24 University College London Nouveau gene
US9220760B2 (en) 2001-03-06 2015-12-29 The Administrators Of The Tulane Educational Fund Method of modulating the proliferation of medullary thyroid carcinoma cells
US9579364B2 (en) 2002-01-22 2017-02-28 New York University Methods for treating benign prostatic hypertrophy (BPH)
EP3241560A1 (fr) 2008-11-17 2017-11-08 Ipsen Bioinnovation Limited Suppression du cancer
EP3473643A1 (fr) 2008-06-12 2019-04-24 Ipsen Bioinnovation Limited Protéines de fusion pour leur utilisation dans le traitement du cancer
EP3590956A1 (fr) 2008-06-12 2020-01-08 Ipsen Bioinnovation Limited Suppression de maladies neuroendocrines

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CN101935252B (zh) * 2010-07-29 2013-01-30 广东省农业科学院科技情报研究所 一种园林植物生长延缓剂及其制备方法
RU2663455C2 (ru) * 2012-04-12 2018-08-06 Новартис Аг КОМБИНАЦИЯ АНАЛОГОВ СОМАТОСТАТИНА С ИНГИБИТОРАМИ 11β- ГИДРОКСИЛАЗЫ
CN105168115A (zh) * 2015-09-02 2015-12-23 中国药科大学 生长抑素类似物多肽药物的口服给药途径
WO2017212390A1 (fr) * 2016-06-06 2017-12-14 Emcure Pharmaceuticals Ltd, Procédé de préparation d'acétate de lanréotide

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1040837A3 (fr) * 1999-02-26 2002-01-02 Erasmus Universiteit Rotterdam Médicaments pour le traitement des troubles liés à la néovascularisation de lachoroide
WO2002009739A1 (fr) * 2000-07-27 2002-02-07 Novartis Ag Traitement de troubles oculaires au moyen d'analogues de la somatostatine
US6316414B1 (en) 2000-07-31 2001-11-13 Dabur Research Foundation Somatostatin analogs for the treatment of cancer
US9220760B2 (en) 2001-03-06 2015-12-29 The Administrators Of The Tulane Educational Fund Method of modulating the proliferation of medullary thyroid carcinoma cells
WO2002083895A2 (fr) * 2001-04-18 2002-10-24 University College London Nouveau gene
WO2002083895A3 (fr) * 2001-04-18 2003-02-06 Univ London Nouveau gene
US9579364B2 (en) 2002-01-22 2017-02-28 New York University Methods for treating benign prostatic hypertrophy (BPH)
EP3473643A1 (fr) 2008-06-12 2019-04-24 Ipsen Bioinnovation Limited Protéines de fusion pour leur utilisation dans le traitement du cancer
EP3590956A1 (fr) 2008-06-12 2020-01-08 Ipsen Bioinnovation Limited Suppression de maladies neuroendocrines
EP3241560A1 (fr) 2008-11-17 2017-11-08 Ipsen Bioinnovation Limited Suppression du cancer

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AU2004201783A1 (en) 2004-05-27
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AR023633A1 (es) 2002-09-04
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KR20010071071A (ko) 2001-07-28

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