WO1999012964A3 - Kay, nouvelle proteine du systeme immunitaire - Google Patents

Kay, nouvelle proteine du systeme immunitaire Download PDF

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Publication number
WO1999012964A3
WO1999012964A3 PCT/US1998/019037 US9819037W WO9912964A3 WO 1999012964 A3 WO1999012964 A3 WO 1999012964A3 US 9819037 W US9819037 W US 9819037W WO 9912964 A3 WO9912964 A3 WO 9912964A3
Authority
WO
WIPO (PCT)
Prior art keywords
kay
immune system
system protein
novel immune
novel
Prior art date
Application number
PCT/US1998/019037
Other languages
English (en)
Other versions
WO1999012964A2 (fr
Inventor
Jurg Tschopp
Original Assignee
Biogen Inc
Jurg Tschopp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP98946052A priority Critical patent/EP1012270A2/fr
Priority to JP2000510769A priority patent/JP2001515711A/ja
Priority to HU0004034A priority patent/HUP0004034A3/hu
Priority to SK353-2000A priority patent/SK3532000A3/sk
Application filed by Biogen Inc, Jurg Tschopp filed Critical Biogen Inc
Priority to AU93152/98A priority patent/AU9315298A/en
Priority to CA002303424A priority patent/CA2303424A1/fr
Priority to EA200000311A priority patent/EA200000311A1/ru
Priority to IL13448098A priority patent/IL134480A0/xx
Priority to BR9812433-1A priority patent/BR9812433A/pt
Priority to EEP200000148A priority patent/EE200000148A/xx
Priority to KR1020007002576A priority patent/KR20010023892A/ko
Publication of WO1999012964A2 publication Critical patent/WO1999012964A2/fr
Publication of WO1999012964A3 publication Critical patent/WO1999012964A3/fr
Priority to IS5375A priority patent/IS5375A/is
Priority to NO20001240A priority patent/NO20001240L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Cette invention se rapporte à Kay, nouveau membre de la famille des facteurs de nécrose des tumeurs (TNF), à des ligands Kay modifiés et à des compositions pharmaceutiques qui les renferment.
PCT/US1998/019037 1997-09-12 1998-09-11 Kay, nouvelle proteine du systeme immunitaire WO1999012964A2 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CA002303424A CA2303424A1 (fr) 1997-09-12 1998-09-11 Kay, nouvelle proteine du systeme immunitaire
HU0004034A HUP0004034A3 (en) 1997-09-12 1998-09-11 Kay - a novel immune system protein
SK353-2000A SK3532000A3 (en) 1997-09-12 1998-09-11 Dna sequence coding for kay ligand, method for the preparation of kay ligand, pharmaceutical composition containing said ligand and the use thereof
IL13448098A IL134480A0 (en) 1997-09-12 1998-09-11 Kay - an immune system protein and dna sequences encoding the same
AU93152/98A AU9315298A (en) 1997-09-12 1998-09-11 Kay - a novel immune system protein
JP2000510769A JP2001515711A (ja) 1997-09-12 1998-09-11 Ｋａｙ−新規の免疫系タンパク質
EA200000311A EA200000311A1 (ru) 1997-09-12 1998-09-11 Новый белок иммунной системы - кау
EP98946052A EP1012270A2 (fr) 1997-09-12 1998-09-11 Kay, nouvelle proteine du systeme immunitaire
BR9812433-1A BR9812433A (pt) 1997-09-12 1998-09-11 Kay- uma proteìna do sistema de imunização
EEP200000148A EE200000148A (et) 1997-09-12 1998-09-11 Kay - uus immuunsüsteemi valk
KR1020007002576A KR20010023892A (ko) 1997-09-12 1998-09-11 Ｋａｙ-신규 면역계 단백질
IS5375A IS5375A (is) 1997-09-12 2000-02-11 KAY-nýstárlegt ónæmisprótín
NO20001240A NO20001240L (no) 1997-09-12 2000-03-09 Kay-A immunsystemprotein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5878697P 1997-09-12 1997-09-12
US60/058,786 1997-09-12

Publications (2)

Publication Number Publication Date
WO1999012964A2 WO1999012964A2 (fr) 1999-03-18
WO1999012964A3 true WO1999012964A3 (fr) 1999-05-27

Family

ID=22018915

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/019037 WO1999012964A2 (fr) 1997-09-12 1998-09-11 Kay, nouvelle proteine du systeme immunitaire

Country Status (17)

Country Link
EP (1) EP1012270A2 (fr)
JP (1) JP2001515711A (fr)
KR (1) KR20010023892A (fr)
CN (1) CN1269832A (fr)
AU (1) AU9315298A (fr)
BR (1) BR9812433A (fr)
CA (1) CA2303424A1 (fr)
EA (1) EA200000311A1 (fr)
EE (1) EE200000148A (fr)
HU (1) HUP0004034A3 (fr)
IL (1) IL134480A0 (fr)
IS (1) IS5375A (fr)
NO (1) NO20001240L (fr)
PL (1) PL339740A1 (fr)
SK (1) SK3532000A3 (fr)
TR (1) TR200000654T2 (fr)
WO (1) WO1999012964A2 (fr)

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US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
WO1999026463A2 (fr) * 1997-11-26 1999-06-03 Eli Lilly And Company Gene de la famille des ligand tnf
WO1999033980A2 (fr) * 1997-12-30 1999-07-08 Chiron Corporation Membres de familles de tnf et de tnfr
US6297367B1 (en) 1997-12-30 2001-10-02 Chiron Corporation Polynucleotide encoding TNFL1
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
GB9828628D0 (en) 1998-12-23 1999-02-17 Glaxo Group Ltd Novel ligand
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
EP2319527A3 (fr) 1999-01-25 2011-10-12 Biogen Idec MA Inc. BAFF, ses inhibiteurs et leur utilisation pour moduler la réponse immunitaire des cellules B et des immunoglobulines
US20030095967A1 (en) 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
US6475986B1 (en) * 1999-02-02 2002-11-05 Research Development Foundation Uses of THANK, a TNF homologue that activates apoptosis
JP2003526330A (ja) * 1999-02-23 2003-09-09 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ニュートロカイン−αおよびニュートロカイン−αスプライス改変体
US20030022233A1 (en) 1999-04-30 2003-01-30 Raymond G. Goodwin Methods of use of the taci/taci-l interaction
WO2000068378A1 (fr) * 1999-05-06 2000-11-16 National Jewish Medical And Research Center Molecules d'acide nucleique, proteines et recepteurs tall-1, et procedes d'utilisation
GEP20053685B (en) * 1999-08-17 2005-12-12 Biogen Inc BAFF Receptor (BCMA), an Immunoregulatory Agent
UA74798C2 (uk) 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
AU3495301A (en) 2000-02-11 2001-08-20 Biogen Inc Heterologous polypeptide of the tnf family
CA2396793A1 (fr) 2000-02-16 2001-08-23 Genentech, Inc. Utilisation d'agonistes ou d'antagonistes pour moduler l'activite de molecules associees au tnf
MXPA02011130A (es) 2000-05-12 2003-03-10 Amgen Inc Metodos y composiciones de materia que se refieren a april/g70, bcma, blys/agp-3, y taci.
US7220840B2 (en) 2000-06-16 2007-05-22 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator protein
PT2281843T (pt) 2000-06-16 2017-01-02 Human Genome Sciences Inc Anticorpos que se ligam imunoespecificamente a blys
CA2419661A1 (fr) * 2000-08-15 2002-03-07 Guo-Liang Yu Neutrokine-alpha et variant d'epissage de neutrokine-alpha
AU2001288301A1 (en) 2000-08-18 2002-03-04 Human Genome Sciences, Inc. Binding polypeptides and methods based thereon
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
EA010435B1 (ru) 2001-05-11 2008-08-29 Амген, Инк. Связывающиеся с tall-1 молекулы и их применение
AR035119A1 (es) 2001-08-16 2004-04-14 Lilly Co Eli Anticuerpos humanos antagonistas anti-htnfsf13b
AU2004233164B2 (en) 2003-03-28 2009-10-08 Biogen Ma Inc. Truncated BAFF receptors
KR20060027801A (ko) 2003-06-05 2006-03-28 제넨테크, 인크. Ｂ 세포 장애에 대한 조합 요법
CN1897966A (zh) 2003-10-20 2007-01-17 比奥根艾迪克Ma公司 使用baff拮抗剂的治疗方法
CA2554526A1 (fr) * 2004-01-29 2005-08-18 Genentech, Inc. Variants du domaine extracellulaire de bcma et utilisations de ceux-ci
US20060110387A1 (en) 2004-10-05 2006-05-25 Genentech, Inc. Method for treating vasculitis
EP2332563A3 (fr) 2004-10-13 2013-03-13 The Washington University Utilisation de BAFF pour traiter la sepsie
JP2008525002A (ja) 2004-12-23 2008-07-17 ラボラトワール セローノ ソシエテ アノニム Ｂｃｍａポリペプチド及びその使用
CN101262876A (zh) 2005-08-09 2008-09-10 酶遗传学股份有限公司 用taci-ig融合分子治疗b细胞恶性肿瘤的方法
US8808696B2 (en) 2005-08-09 2014-08-19 Ares Trading S.A. Methods for the treatment and prevention of abnormal cell proliferation using TACI-fusion molecules
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
WO2007062090A2 (fr) 2005-11-23 2007-05-31 Genentech, Inc. Procedes et compositions lies a des analyses de lymphocytes b
US8211649B2 (en) 2006-03-31 2012-07-03 Human Genome Sciences, Inc. Methods of diagnosing and prognosing hodgkin's lymphoma
EA015342B1 (ru) 2006-05-15 2011-06-30 Арес Трейдинг С.А. Способы лечения аутоиммунных заболеваний с использованием слитой молекулы taci-ig
WO2010075249A2 (fr) 2008-12-22 2010-07-01 Genentech, Inc. Méthode de traitement de la polyarthrite rhumatoïde avec des antagonistes de cellules b
MX353186B (es) 2009-09-03 2018-01-05 Genentech Inc Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide.
RU2013140975A (ru) 2011-02-28 2015-04-10 Дженентек, Инк. Биологические маркеры и способы прогнозирования восприимчивости к антагонистам в-клеток
WO2014122144A1 (fr) 2013-02-05 2014-08-14 Engmab Ag Anticorps bispécifiques anti-cd3ɛ et bcma
JOP20140087B1 (ar) 2013-03-13 2021-08-17 Amgen Inc بروتينات مخصصة ل baff و b7rp1 وإستخداماتها
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
US10138251B2 (en) 2014-04-11 2018-11-27 Boehringer Ingelheim International Gmbh Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors

Citations (5)

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Publication number Priority date Publication date Assignee Title
WO1994018325A1 (fr) * 1993-02-03 1994-08-18 N.V. Innogenetics S.A. Muteines de tnf-alpha et leur procede de preparation
WO1996040774A1 (fr) * 1995-06-07 1996-12-19 Biogen, Inc. Complexes de lymphotoxines modifiees utilises comme preparations pharmaceutiques
WO1998018921A1 (fr) * 1996-10-25 1998-05-07 Human Genome Sciences, Inc. Neutrokine alpha
WO1998027114A2 (fr) * 1996-12-17 1998-06-25 Schering Corporation Antigenes de surface mammaliens et reactifs associes
EP0869180A1 (fr) * 1997-04-02 1998-10-07 Smithkline Beecham Corporation Un homologue de TNF, TL5

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018325A1 (fr) * 1993-02-03 1994-08-18 N.V. Innogenetics S.A. Muteines de tnf-alpha et leur procede de preparation
WO1996040774A1 (fr) * 1995-06-07 1996-12-19 Biogen, Inc. Complexes de lymphotoxines modifiees utilises comme preparations pharmaceutiques
WO1998018921A1 (fr) * 1996-10-25 1998-05-07 Human Genome Sciences, Inc. Neutrokine alpha
WO1998027114A2 (fr) * 1996-12-17 1998-06-25 Schering Corporation Antigenes de surface mammaliens et reactifs associes
EP0869180A1 (fr) * 1997-04-02 1998-10-07 Smithkline Beecham Corporation Un homologue de TNF, TL5

Also Published As

Publication number Publication date
EA200000311A1 (ru) 2000-10-30
HUP0004034A3 (en) 2002-08-28
JP2001515711A (ja) 2001-09-25
CA2303424A1 (fr) 1999-03-18
EE200000148A (et) 2001-02-15
WO1999012964A2 (fr) 1999-03-18
CN1269832A (zh) 2000-10-11
SK3532000A3 (en) 2001-12-03
NO20001240D0 (no) 2000-03-09
KR20010023892A (ko) 2001-03-26
IS5375A (is) 2000-02-11
IL134480A0 (en) 2001-04-30
AU9315298A (en) 1999-03-29
NO20001240L (no) 2000-05-10
HUP0004034A2 (en) 2001-03-28
TR200000654T2 (tr) 2000-07-21
EP1012270A2 (fr) 2000-06-28
BR9812433A (pt) 2000-09-26
PL339740A1 (en) 2001-01-02

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