WO1998042840A1 - Homologues de la motiline - Google Patents

Homologues de la motiline Download PDF

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Publication number
WO1998042840A1
WO1998042840A1 PCT/US1998/005620 US9805620W WO9842840A1 WO 1998042840 A1 WO1998042840 A1 WO 1998042840A1 US 9805620 W US9805620 W US 9805620W WO 9842840 A1 WO9842840 A1 WO 9842840A1
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
nucleotide
seq
residue
amino acid
Prior art date
Application number
PCT/US1998/005620
Other languages
English (en)
Inventor
Paul O. Sheppard
Theresa A. Deisher
Original Assignee
Zymogenetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/822,897 external-priority patent/US6380158B1/en
Application filed by Zymogenetics, Inc. filed Critical Zymogenetics, Inc.
Priority to BR9808059-8A priority Critical patent/BR9808059A/pt
Priority to NZ337958A priority patent/NZ337958A/xx
Priority to DE69840496T priority patent/DE69840496D1/de
Priority to AU65769/98A priority patent/AU726423B2/en
Priority to JP54327698A priority patent/JP4335318B2/ja
Priority to EP98911928A priority patent/EP0975760B1/fr
Priority to KR1019997008769A priority patent/KR20010005701A/ko
Priority to CA2284733A priority patent/CA2284733C/fr
Publication of WO1998042840A1 publication Critical patent/WO1998042840A1/fr
Priority to NO994614A priority patent/NO994614L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des polynucléotides, des polypetides et certains de leurs fragments peptidiques, mais également leurs utilisations pour une séquence d'ADN complémentaire présentant une homologie avec la motiline. La distribution tissulaire de l'ARN messager pour le polypeptide de l'invention est spécifique de l'estomac, de l'intestin grêle et du pancréas. L'invention concerne en outre, non seulement des agonistes, des antagonistes, des anticorps et des cellules hôte exprimant l'ADN complémentaire codant pour les homologues de la motiline de l'invention, mais aussi des procédés permettant d'accroître la motilité gastrique par utilisation des molécules de l'invention.
PCT/US1998/005620 1997-03-24 1998-03-23 Homologues de la motiline WO1998042840A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BR9808059-8A BR9808059A (pt) 1997-03-24 1998-03-23 Molécula de plinucleotìdeo isolada codificando um polipeptìdeo, polinucleotìdeo, vetor de expressão, célula cultivada, polipeptìdeo isolado, composição farmacêutica, anticorpo, processos para produzir polipeptìdeo zsig33, e, para estimular a motilidde gástrica
NZ337958A NZ337958A (en) 1997-03-24 1998-03-23 Motilin homolog designated zsig33 for treating gastrointestinal cell contractility, secretion of digestive enzymes, gastrointestinal motility, recruitment of digestive enzymes, reflux disease and regulation of nutrient absorption
DE69840496T DE69840496D1 (de) 1997-03-24 1998-03-23 Motlinhomologe
AU65769/98A AU726423B2 (en) 1997-03-24 1998-03-23 Motilin homologs
JP54327698A JP4335318B2 (ja) 1997-03-24 1998-03-23 モチリン相同体
EP98911928A EP0975760B1 (fr) 1997-03-24 1998-03-23 Homologues de la motiline
KR1019997008769A KR20010005701A (ko) 1997-03-24 1998-03-23 모틸린 상동체
CA2284733A CA2284733C (fr) 1997-03-24 1998-03-23 Homologues de la motiline
NO994614A NO994614L (no) 1997-03-24 1999-09-23 Motilinhomologer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4110297P 1997-03-24 1997-03-24
US08/822,897 US6380158B1 (en) 1997-03-24 1997-03-24 Motilin homologs
US08/822,897 1997-03-24
US60/041,102 1997-03-24

Publications (1)

Publication Number Publication Date
WO1998042840A1 true WO1998042840A1 (fr) 1998-10-01

Family

ID=26717805

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/005620 WO1998042840A1 (fr) 1997-03-24 1998-03-23 Homologues de la motiline

Country Status (9)

Country Link
JP (1) JP4335318B2 (fr)
KR (1) KR20010005701A (fr)
CN (1) CN1170933C (fr)
AU (1) AU726423B2 (fr)
BR (1) BR9808059A (fr)
CA (1) CA2284733C (fr)
NO (1) NO994614L (fr)
NZ (1) NZ337958A (fr)
WO (1) WO1998042840A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000830A1 (fr) * 1999-06-30 2001-01-04 Zymogenetics, Inc. Peptides sgip
WO2001007475A1 (fr) * 1999-07-23 2001-02-01 Kenji Kangawa Nouveaux peptides
WO2001038355A2 (fr) 1999-11-22 2001-05-31 Zymogenetics, Inc. Procede de formation d'un complexe peptide-recepteur a l'aide de polypeptides zsig33
WO2001087933A3 (fr) * 2000-05-11 2002-07-11 Zymogenetics Inc Peptides de type zsig33
US6420521B1 (en) 1999-06-30 2002-07-16 Zymogenetics, Inc. Short gastrointestinal peptides
US6627729B1 (en) 1997-03-24 2003-09-30 Zymogenetics, Inc. TML peptides
US6897286B2 (en) 2000-05-11 2005-05-24 Zymogenetics, Inc. Zsig33-like peptides
US6967237B2 (en) 2000-05-30 2005-11-22 Merck & Co., Inc. Ghrelin analogs
EP2210612A2 (fr) 2003-06-18 2010-07-28 Tranzyme Pharma Inc. Antagonistes macrocycliques du récépteur de motiline
EP2431380A2 (fr) 2006-09-11 2012-03-21 Tranzyme Pharma, Inc. Antagoniste macrocyclique du récepteur de motiline pour le traitement des troubles de dysmotilité gastro-intestinale

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102574904B (zh) * 2009-07-29 2014-11-26 第一三共株式会社 赋予了经粘膜吸收性的胃动素样肽化合物
JP7049775B2 (ja) 2017-04-03 2022-04-07 リンナイ株式会社 表示装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989007611A1 (fr) * 1988-02-09 1989-08-24 The State Of Oregon Acting By And Through The Stat Peptide associe a la prepromotiline et a la motiline (map)
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5143830A (en) 1986-05-15 1992-09-01 Holland Ian B Process for the production of a polypeptide
EP0505846A1 (fr) * 1991-03-27 1992-09-30 Sanwa Kagaku Kenkyusho Co., Ltd. Procédé pour la conversion d'une protéine fusionée en analogues actives de la motiline humaine et purification de ces analogues

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143830A (en) 1986-05-15 1992-09-01 Holland Ian B Process for the production of a polypeptide
WO1989007611A1 (fr) * 1988-02-09 1989-08-24 The State Of Oregon Acting By And Through The Stat Peptide associe a la prepromotiline et a la motiline (map)
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
EP0505846A1 (fr) * 1991-03-27 1992-09-30 Sanwa Kagaku Kenkyusho Co., Ltd. Procédé pour la conversion d'une protéine fusionée en analogues actives de la motiline humaine et purification de ces analogues

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
COLLINS ET AL., GUT, vol. 24, 1983, pages 1117
HOROWITZ ET AL., ARCH. INTERN. MED., vol. 145, 1985, pages 1467 - 1472
MAUGHAN ET AL., DIABET. MED., vol. 13 9, no. 5, 1996, pages 6 - 10
MEYER ET AL., AM. J. DIQ. DIS., vol. 21, 1976, pages 296
NCI-CGAP: "Homo sapiens cDNA clone (AC No. AA530994).", EMBL SEQUENCE DATABASE, 24 July 1997 (1997-07-24), HEIDELBERG, GERMANY, XP002067112 *
SUGANO K. ET AL.: "Identification and characterization of glycine-extended post-translational processing intermediates of progastrin in procine stomach", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 260, no. 21, 25 September 1985 (1985-09-25), pages 11724 - 11729, XP002067111 *

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354739B2 (en) 1997-03-24 2008-04-08 Zymogenetics, Inc. TML polynucleotides
US6627729B1 (en) 1997-03-24 2003-09-30 Zymogenetics, Inc. TML peptides
US6420521B1 (en) 1999-06-30 2002-07-16 Zymogenetics, Inc. Short gastrointestinal peptides
WO2001000830A1 (fr) * 1999-06-30 2001-01-04 Zymogenetics, Inc. Peptides sgip
AU2006201580B2 (en) * 1999-07-23 2009-01-08 Kenji Kangawa Novel peptides
CN101693736A (zh) * 1999-07-23 2010-04-14 寒川贤治 新的肽
US9938332B2 (en) 1999-07-23 2018-04-10 Kenji Kanagawa Modified ghrelin peptides
US9573986B2 (en) 1999-07-23 2017-02-21 Kenji Kangawa Modified ghrelin peptides
US8524871B2 (en) 1999-07-23 2013-09-03 Kenji Kangawa Modified gherlin peptides
US8227570B2 (en) 1999-07-23 2012-07-24 Kenji Kanagawa Modified gherlin peptides
EP1795598A1 (fr) * 1999-07-23 2007-06-13 Kenji Kangawa Nouveaux peptides
US20110184153A1 (en) * 1999-07-23 2011-07-28 Kenji Kangawa Modified gherlin peptides
US7385026B1 (en) 1999-07-23 2008-06-10 Kenji Kangawa Modified ghrelin polypeptides
US20100240866A1 (en) * 1999-07-23 2010-09-23 Kenji Kangawa Modified gherlin peptides
WO2001007475A1 (fr) * 1999-07-23 2001-02-01 Kenji Kangawa Nouveaux peptides
EP2119785A1 (fr) 1999-07-23 2009-11-18 Kenji Kangawa Nouveaux peptides
WO2001038355A2 (fr) 1999-11-22 2001-05-31 Zymogenetics, Inc. Procede de formation d'un complexe peptide-recepteur a l'aide de polypeptides zsig33
US7888056B2 (en) 1999-11-22 2011-02-15 Zymogenetics, Inc. Method of forming a peptide-receptor complex with zsig33
JP4800537B2 (ja) * 1999-11-22 2011-10-26 ザイモジェネティクス， インコーポレイテッド Ｚｓｉｇ３３によるペプチド−受容体複合体の形成方法
US8124356B2 (en) 1999-11-22 2012-02-28 Zymogenetics, Inc. Methods of purifying zsig33
WO2001038355A3 (fr) * 1999-11-22 2001-11-22 Zymogenetics Inc Procede de formation d'un complexe peptide-recepteur a l'aide de polypeptides zsig33
JP2003514917A (ja) * 1999-11-22 2003-04-22 ザイモジェネティクス，インコーポレイティド Ｚｓｉｇ３３によるペプチド−受容体複合体の形成方法
US7655447B2 (en) 2000-05-11 2010-02-02 Zymogenetics, Inc. ZSIG33-like polynucleotides
US7445919B2 (en) 2000-05-11 2008-11-04 Zymogenetics, Inc. Zsig33-like peptides and polynucleotides
WO2001087933A3 (fr) * 2000-05-11 2002-07-11 Zymogenetics Inc Peptides de type zsig33
US6897286B2 (en) 2000-05-11 2005-05-24 Zymogenetics, Inc. Zsig33-like peptides
US6967237B2 (en) 2000-05-30 2005-11-22 Merck & Co., Inc. Ghrelin analogs
EP2210612A2 (fr) 2003-06-18 2010-07-28 Tranzyme Pharma Inc. Antagonistes macrocycliques du récépteur de motiline
EP2431380A2 (fr) 2006-09-11 2012-03-21 Tranzyme Pharma, Inc. Antagoniste macrocyclique du récepteur de motiline pour le traitement des troubles de dysmotilité gastro-intestinale

Also Published As

Publication number Publication date
AU726423B2 (en) 2000-11-09
CN1170933C (zh) 2004-10-13
JP2001513651A (ja) 2001-09-04
JP4335318B2 (ja) 2009-09-30
CA2284733C (fr) 2010-10-26
CA2284733A1 (fr) 1998-10-01
NO994614D0 (no) 1999-09-23
BR9808059A (pt) 2000-03-08
NO994614L (no) 1999-11-23
NZ337958A (en) 2001-03-30
CN1254375A (zh) 2000-05-24
AU6576998A (en) 1998-10-20
KR20010005701A (ko) 2001-01-15

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