CA2284733C - Homologues de la motiline - Google Patents
Homologues de la motiline Download PDFInfo
- Publication number
- CA2284733C CA2284733C CA2284733A CA2284733A CA2284733C CA 2284733 C CA2284733 C CA 2284733C CA 2284733 A CA2284733 A CA 2284733A CA 2284733 A CA2284733 A CA 2284733A CA 2284733 C CA2284733 C CA 2284733C
- Authority
- CA
- Canada
- Prior art keywords
- residue
- polypeptide
- seq
- amino acid
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne des polynucléotides, des polypetides et certains de leurs fragments peptidiques, mais également leurs utilisations pour une séquence d'ADN complémentaire présentant une homologie avec la motiline. La distribution tissulaire de l'ARN messager pour le polypeptide de l'invention est spécifique de l'estomac, de l'intestin grêle et du pancréas. L'invention concerne en outre, non seulement des agonistes, des antagonistes, des anticorps et des cellules hôte exprimant l'ADN complémentaire codant pour les homologues de la motiline de l'invention, mais aussi des procédés permettant d'accroître la motilité gastrique par utilisation des molécules de l'invention.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4110297P | 1997-03-24 | 1997-03-24 | |
US08/822,897 US6380158B1 (en) | 1997-03-24 | 1997-03-24 | Motilin homologs |
US60/041,102 | 1997-03-24 | ||
US08/822,897 | 1997-03-24 | ||
PCT/US1998/005620 WO1998042840A1 (fr) | 1997-03-24 | 1998-03-23 | Homologues de la motiline |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2284733A1 CA2284733A1 (fr) | 1998-10-01 |
CA2284733C true CA2284733C (fr) | 2010-10-26 |
Family
ID=26717805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2284733A Expired - Fee Related CA2284733C (fr) | 1997-03-24 | 1998-03-23 | Homologues de la motiline |
Country Status (9)
Country | Link |
---|---|
JP (1) | JP4335318B2 (fr) |
KR (1) | KR20010005701A (fr) |
CN (1) | CN1170933C (fr) |
AU (1) | AU726423B2 (fr) |
BR (1) | BR9808059A (fr) |
CA (1) | CA2284733C (fr) |
NO (1) | NO994614L (fr) |
NZ (1) | NZ337958A (fr) |
WO (1) | WO1998042840A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6627729B1 (en) | 1997-03-24 | 2003-09-30 | Zymogenetics, Inc. | TML peptides |
JP2003503055A (ja) * | 1999-06-30 | 2003-01-28 | ザイモジェネティクス,インコーポレイティド | Sgipペプチド |
US6420521B1 (en) | 1999-06-30 | 2002-07-16 | Zymogenetics, Inc. | Short gastrointestinal peptides |
EP1795598B1 (fr) * | 1999-07-23 | 2009-11-18 | Kenji Kangawa | Nouveaux peptides |
CA2392019A1 (fr) | 1999-11-22 | 2001-05-31 | Zymogenetics, Inc. | Methode permettant de produire un complexe forme d'un recepteur peptidique et de zsig33 |
ATE473280T1 (de) * | 2000-05-11 | 2010-07-15 | Zymogenetics Inc | Zsig33-ähnliche peptide |
US6897286B2 (en) | 2000-05-11 | 2005-05-24 | Zymogenetics, Inc. | Zsig33-like peptides |
JP2004514651A (ja) | 2000-05-30 | 2004-05-20 | メルク エンド カムパニー インコーポレーテッド | グレリン類似体 |
EP2210612B1 (fr) | 2003-06-18 | 2016-10-05 | Ocera Therapeutics, Inc. | Antagonistes macrocycliques du récepteur de motiline |
WO2008033328A2 (fr) | 2006-09-11 | 2008-03-20 | Tranzyme Pharma, Inc. | Antagonistes macrocycliques du récepteur de la motiline pour le traitement de troubles de dysmotilité gastro-intestinale |
CA2769013C (fr) * | 2009-07-29 | 2015-04-07 | Daiichi Sankyo Company, Limited | Compose peptidique de type motiline presentant une faculte d'absorption transmucosale qui lui est associee |
JP7049775B2 (ja) | 2017-04-03 | 2022-04-07 | リンナイ株式会社 | 表示装置 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8611832D0 (en) | 1986-05-15 | 1986-06-25 | Holland I B | Polypeptide |
US5006469A (en) * | 1988-02-09 | 1991-04-09 | Oregon Health Sciences University | Vectors and host cells expressing prepromotilin and motilin-associated peptide (MAP) |
US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
JPH04299990A (ja) * | 1991-03-27 | 1992-10-23 | Sanwa Kagaku Kenkyusho Co Ltd | モチリンアナログの精製方法 |
-
1998
- 1998-03-23 KR KR1019997008769A patent/KR20010005701A/ko not_active Application Discontinuation
- 1998-03-23 AU AU65769/98A patent/AU726423B2/en not_active Ceased
- 1998-03-23 BR BR9808059-8A patent/BR9808059A/pt not_active Application Discontinuation
- 1998-03-23 CN CNB988046822A patent/CN1170933C/zh not_active Expired - Fee Related
- 1998-03-23 WO PCT/US1998/005620 patent/WO1998042840A1/fr not_active Application Discontinuation
- 1998-03-23 JP JP54327698A patent/JP4335318B2/ja not_active Expired - Fee Related
- 1998-03-23 CA CA2284733A patent/CA2284733C/fr not_active Expired - Fee Related
- 1998-03-23 NZ NZ337958A patent/NZ337958A/xx not_active IP Right Cessation
-
1999
- 1999-09-23 NO NO994614A patent/NO994614L/no unknown
Also Published As
Publication number | Publication date |
---|---|
CN1170933C (zh) | 2004-10-13 |
JP4335318B2 (ja) | 2009-09-30 |
NO994614D0 (no) | 1999-09-23 |
NO994614L (no) | 1999-11-23 |
WO1998042840A1 (fr) | 1998-10-01 |
AU6576998A (en) | 1998-10-20 |
JP2001513651A (ja) | 2001-09-04 |
NZ337958A (en) | 2001-03-30 |
CN1254375A (zh) | 2000-05-24 |
AU726423B2 (en) | 2000-11-09 |
KR20010005701A (ko) | 2001-01-15 |
BR9808059A (pt) | 2000-03-08 |
CA2284733A1 (fr) | 1998-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20160323 |