CA2284733C - Homologues de la motiline - Google Patents

Homologues de la motiline Download PDF

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Publication number
CA2284733C
CA2284733C CA2284733A CA2284733A CA2284733C CA 2284733 C CA2284733 C CA 2284733C CA 2284733 A CA2284733 A CA 2284733A CA 2284733 A CA2284733 A CA 2284733A CA 2284733 C CA2284733 C CA 2284733C
Authority
CA
Canada
Prior art keywords
residue
polypeptide
seq
amino acid
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2284733A
Other languages
English (en)
Other versions
CA2284733A1 (fr
Inventor
Paul O. Sheppard
Theresa A. Deisher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/822,897 external-priority patent/US6380158B1/en
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of CA2284733A1 publication Critical patent/CA2284733A1/fr
Application granted granted Critical
Publication of CA2284733C publication Critical patent/CA2284733C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des polynucléotides, des polypetides et certains de leurs fragments peptidiques, mais également leurs utilisations pour une séquence d'ADN complémentaire présentant une homologie avec la motiline. La distribution tissulaire de l'ARN messager pour le polypeptide de l'invention est spécifique de l'estomac, de l'intestin grêle et du pancréas. L'invention concerne en outre, non seulement des agonistes, des antagonistes, des anticorps et des cellules hôte exprimant l'ADN complémentaire codant pour les homologues de la motiline de l'invention, mais aussi des procédés permettant d'accroître la motilité gastrique par utilisation des molécules de l'invention.
CA2284733A 1997-03-24 1998-03-23 Homologues de la motiline Expired - Fee Related CA2284733C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4110297P 1997-03-24 1997-03-24
US08/822,897 US6380158B1 (en) 1997-03-24 1997-03-24 Motilin homologs
US60/041,102 1997-03-24
US08/822,897 1997-03-24
PCT/US1998/005620 WO1998042840A1 (fr) 1997-03-24 1998-03-23 Homologues de la motiline

Publications (2)

Publication Number Publication Date
CA2284733A1 CA2284733A1 (fr) 1998-10-01
CA2284733C true CA2284733C (fr) 2010-10-26

Family

ID=26717805

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2284733A Expired - Fee Related CA2284733C (fr) 1997-03-24 1998-03-23 Homologues de la motiline

Country Status (9)

Country Link
JP (1) JP4335318B2 (fr)
KR (1) KR20010005701A (fr)
CN (1) CN1170933C (fr)
AU (1) AU726423B2 (fr)
BR (1) BR9808059A (fr)
CA (1) CA2284733C (fr)
NO (1) NO994614L (fr)
NZ (1) NZ337958A (fr)
WO (1) WO1998042840A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627729B1 (en) 1997-03-24 2003-09-30 Zymogenetics, Inc. TML peptides
EP1190059A1 (fr) * 1999-06-30 2002-03-27 ZymoGenetics, Inc. Peptides sgip
US6420521B1 (en) 1999-06-30 2002-07-16 Zymogenetics, Inc. Short gastrointestinal peptides
DK1795598T3 (da) * 1999-07-23 2010-02-01 Kenji Kangawa Hidtil ukendte peptider
CA2392019A1 (fr) 1999-11-22 2001-05-31 Zymogenetics, Inc. Methode permettant de produire un complexe forme d'un recepteur peptidique et de zsig33
US6897286B2 (en) 2000-05-11 2005-05-24 Zymogenetics, Inc. Zsig33-like peptides
EP1278852B1 (fr) * 2000-05-11 2010-07-07 ZymoGenetics, Inc. Peptides de type zsig33
WO2001092292A2 (fr) 2000-05-30 2001-12-06 Merck & Co., Inc. Analogues de la ghreline
WO2004111077A1 (fr) 2003-06-18 2004-12-23 Tranzyme Pharma Inc. Antagonistes macrocycliques du recepteur de motiline
EP2431380A3 (fr) 2006-09-11 2013-07-03 Tranzyme Pharma, Inc. Antagoniste macrocyclique du récepteur de motiline pour le traitement des troubles de dysmotilité gastro-intestinale
SG177592A1 (en) * 2009-07-29 2012-02-28 Daiichi Sankyo Co Ltd Motilin-like peptide compound having transmucosal absorbability imparted thereto
JP7049775B2 (ja) 2017-04-03 2022-04-07 リンナイ株式会社 表示装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US5006469A (en) * 1988-02-09 1991-04-09 Oregon Health Sciences University Vectors and host cells expressing prepromotilin and motilin-associated peptide (MAP)
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
JPH04299990A (ja) * 1991-03-27 1992-10-23 Sanwa Kagaku Kenkyusho Co Ltd モチリンアナログの精製方法

Also Published As

Publication number Publication date
KR20010005701A (ko) 2001-01-15
AU6576998A (en) 1998-10-20
JP4335318B2 (ja) 2009-09-30
CA2284733A1 (fr) 1998-10-01
AU726423B2 (en) 2000-11-09
WO1998042840A1 (fr) 1998-10-01
NO994614D0 (no) 1999-09-23
CN1254375A (zh) 2000-05-24
CN1170933C (zh) 2004-10-13
NZ337958A (en) 2001-03-30
BR9808059A (pt) 2000-03-08
JP2001513651A (ja) 2001-09-04
NO994614L (no) 1999-11-23

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Effective date: 20160323