WO1998022218A1 - Flacon a echantillon pour prelevement de sang - Google Patents

Flacon a echantillon pour prelevement de sang Download PDF

Info

Publication number
WO1998022218A1
WO1998022218A1 PCT/DE1997/002712 DE9702712W WO9822218A1 WO 1998022218 A1 WO1998022218 A1 WO 1998022218A1 DE 9702712 W DE9702712 W DE 9702712W WO 9822218 A1 WO9822218 A1 WO 9822218A1
Authority
WO
WIPO (PCT)
Prior art keywords
vessel
blood
sample
capillary
blood collection
Prior art date
Application number
PCT/DE1997/002712
Other languages
German (de)
English (en)
Inventor
Walter Sarstedt
Original Assignee
Sarstedt Ag & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarstedt Ag & Co. filed Critical Sarstedt Ag & Co.
Priority to US09/101,942 priority Critical patent/US6056925A/en
Priority to PL97327663A priority patent/PL185194B1/pl
Priority to CA002241792A priority patent/CA2241792C/fr
Priority to EP97949956A priority patent/EP0877652B1/fr
Priority to JP52307798A priority patent/JP3853374B2/ja
Priority to AU53087/98A priority patent/AU719213B2/en
Priority to DE59712791T priority patent/DE59712791D1/de
Publication of WO1998022218A1 publication Critical patent/WO1998022218A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes

Definitions

  • the invention relates to a sample vessel for taking very small amounts of blood, e.g. from a patient's fingertip or earlobe, so that venous blood withdrawal is often unnecessary.
  • EP 0 517 119 B1 and US Pat. No. 5,458,854 A disclose such blood withdrawal devices with a collection tube for the blood.
  • the tube or the blood collection vessel has an integrated, vessel-like blood collection space with a rounded end open at the top and a rounded end closed at the bottom.
  • the open end of the container is provided in one piece with a lip part in the shape of a shovel, over the receiving edge of which the withdrawn blood can flow into the blood collection space, which is larger in diameter.
  • the upper end of the vessel together with the lip-shaped lip part formed thereon can be closed by a cap. This is attached to the lower end of the vessel while the blood is being drawn.
  • a standard clinical centrifuge according to the.
  • a shovel-shaped lip part serving for blood collection or a capillary tube is an integral part of a cap that can be plugged onto the blood collection vessel.
  • Another problem with the preparation and analysis of very small amounts of blood in the laboratory is to find such vessels that fit on the one hand due to their external dimensions in the common laboratory equipment, can be labeled (e.g. with barcode labels) and still guarantee a fill level of the sample which is still easy to pipette or handle. If vessels with an outer diameter common for commercial centrifuges and the usual wall thicknesses are used, a capillary blood volume with the volume of one or more droplets is so low that the bulk of the blood is distributed over the inner surface of the vessel and therefore almost no sample for the analysis is available. If, on the other hand, vessels with a smaller diameter guaranteeing a sufficient fill level are used, they do not fit into the commercially available devices.
  • vessels that have sufficient dimensions in their relevant upper area suitable for the devices and that taper towards the bottom are that they become Do not let the commercially available barcode labels stick on the tubes.
  • vessels are available on the market whose outer contours correspond to the required dimensions of commercially available laboratory equipment and whose inner vessel diameter is as small and narrow as possible.
  • These large dimensional differences between the outside and inside diameters are compensated for by a relatively large wall thickness.
  • the manufacture of such vessels then leads to the technical problems well known to the injection molding specialist.
  • the required, rather complex injection molding tool for the production of these vessels, which have a large wall thickness is only ever suitable for the manufacture of vessels from plastics of one type.
  • plastics of one type since different types of plastic show different behavior towards blood or other specimen, depending on the requirements for the specimen, vessels made of different types of plastic are also required. This means that each time the manufacture or use of another injection molding tool is necessary, which leads to high investments.
  • the invention has for its object to provide a sample vessel for withdrawing the smallest amounts of blood, with which the aforementioned disadvantages can be remedied and which facilitates blood withdrawal, is easier to manufacture and offers more varied possible uses.
  • a sample vessel which consists of an outer vessel and an inner vessel which can be inserted therein, which is closed at the bottom and is formed at the top, on the outlet side, with an open, very thin-walled blood collection ring which can be closed by a stopper and projects in situ from the outer vessel , wherein the outer vessel has a collar supporting the inner vessel below the blood collection ring and suitable for inclusion in centrifuges. Due to the two-part design of the sample vessel according to the invention with the all-round, very thin-walled blood collection ring of the inner vessel and the support collar of the separate outer vessel, several advantages can be achieved simultaneously.
  • the blood collection ring is also suitable as a seat for a stopper that closes the sample vessel.
  • the outer vessel can - since it is not directly involved in the blood collection - be provided in such a size that it provides a sufficiently large area for the attachment of a measuring or identification carrier (bar code).
  • the collar of the outer vessel fulfills a double function, namely it serves both to support the inner vessel that can be inserted or glued or latched into the outer vessel due to a press fit with a tight fit, and also to support when inserting it into any of the centrifuges common on the market.
  • FIG. 1 in an explosive representation the overall view of the individual parts of a first embodiment of a schematically shown sample vessel.
  • FIG. 2 shows the sample vessel according to FIG. 1 ready for taking blood;
  • FIG. 3 shows the sample vessel according to FIG. 2 in a modified version with an attachable capillary
  • a sample vessel 1 shown in FIG. 1 consists of a tubular outer vessel 2, an inner vessel 3 and a stopper 4.
  • the outer vessel 2 is provided with a collar 5, to which, in the installation position shown in FIG. 2, there is a press fit in the outer vessel 2 inserted inner vessel 3 supports.
  • the inner vessel 3 closed at the bottom has, in the embodiment shown, a conical vessel section 6 which, especially in the case of inner vessels designed with a small filling volume, nevertheless ensures a high level of the serum or plasma after centrifugation, which allows the desired amount of liquid to be pipetted off easily and simply.
  • the inner vessel 3 is formed with an extension in the form of a very thin-walled blood collection ring 7, which allows an all-round collection of the blood collected in the inner vessel 3, so that the sample vessel 1 can be placed at any point on the blood collection ring 7; it is therefore possible to draw peripheral blood easily by scooping up the escaping blood.
  • the stopper 4, which is attached to the blood collection ring 7 of the inner vessel 3 in the delivery state, can be inserted into the lower end of the outer vessel 2 during the blood uptake, as illustrated in FIG. 2 by the arrow 8.
  • the two-part sample vessel 1 also offers in a simple manner the possibility of taking blood through a capillary 9.
  • This is arranged there in a holding plug 10 which is pushed onto the blood collecting ring 7, so that the lower end of the capillary in the inner vessel 3 opens and consequently leads the drawn blood into the inner vessel 3.
  • a suitable venting of the inner vessel ensures that the blood gets into the capillary 9.
  • the stopper 10 carrying the capillary 9 closes the inner vessel 3, while a closure stopper 4, as shown in FIG. 2, not shown here, closes the lower end of the outer vessel 2 is inserted.
  • the empty capillary 9, together with the holding plug 10 is removed from the sample vessel 1 or the blood collection ring 7 of the inner vessel 3 and disposed of; the stopper 4 is then placed on the blood collection ring 7 and the sample vessel 1 is thus closed.
  • the inner vessel 3 can be designed with a flow aid 11, the embodiment of the flow aid 11 shown in FIG. 4 being a largely simplified production, eg by milling.

Abstract

L'invention concerne un flacon à échantillon (1) pour le prélèvement de quantités de sang extrêmement petites, constitué d'un flacon extérieur (2) et d'un flacon intérieur (3), inséré dans ledit flacon extérieur, qui est fermé en bas et présente, en haut, côté prélèvement, une bague de prélèvement (7) à paroi très mince, ouverte, pouvant être fermée par un bouchon (4), qui fait saillie du flacon extérieur (2) lorsqu'elle est en place. Le flacon extérieur (2) comporte une collerette (5) qui soutient le flacon intérieur (3) en-dessous de la bague de prélèvement (7) et permet le logement du flacon à échantillon dans des centrifugeuses. Un tel flacon à échantillon facilite le prélèvement de sang, est plus simple à fabriquer et offre des possibilités d'utilisation plus diverses.
PCT/DE1997/002712 1996-11-19 1997-11-18 Flacon a echantillon pour prelevement de sang WO1998022218A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US09/101,942 US6056925A (en) 1996-11-19 1997-11-18 Sample vessel for taking blood samples
PL97327663A PL185194B1 (pl) 1996-11-19 1997-11-18 Naczynie do pobierania próbek krwi
CA002241792A CA2241792C (fr) 1996-11-19 1997-11-18 Flacon a echantillon pour prelevement de sang
EP97949956A EP0877652B1 (fr) 1996-11-19 1997-11-18 Flacon a echantillon pour prelevement de sang
JP52307798A JP3853374B2 (ja) 1996-11-19 1997-11-18 採血のための試料容器
AU53087/98A AU719213B2 (en) 1996-11-19 1997-11-18 Sample vessel for taking blood samples
DE59712791T DE59712791D1 (de) 1996-11-19 1997-11-18 Probengefäss zur blutabnahme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19647673.9 1996-11-19
DE19647673A DE19647673C2 (de) 1996-11-19 1996-11-19 Probengefäß zur Blutabnahme

Publications (1)

Publication Number Publication Date
WO1998022218A1 true WO1998022218A1 (fr) 1998-05-28

Family

ID=7812024

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1997/002712 WO1998022218A1 (fr) 1996-11-19 1997-11-18 Flacon a echantillon pour prelevement de sang

Country Status (10)

Country Link
US (1) US6056925A (fr)
EP (1) EP0877652B1 (fr)
JP (1) JP3853374B2 (fr)
AT (1) ATE350165T1 (fr)
AU (1) AU719213B2 (fr)
CA (1) CA2241792C (fr)
DE (2) DE19647673C2 (fr)
ES (1) ES2283030T3 (fr)
PL (1) PL185194B1 (fr)
WO (1) WO1998022218A1 (fr)

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JP4125603B2 (ja) 2001-05-07 2008-07-30 株式会社共立理化学研究所 簡易分析具及びその製造方法
US6878346B2 (en) * 2002-05-17 2005-04-12 Bayer Corporation Serum transfer cup
US20060018799A1 (en) * 2004-07-21 2006-01-26 Wong Cai Ne W Universal tissue homogenizer device and methods
JP2007167123A (ja) * 2005-12-19 2007-07-05 Fujifilm Corp 真空採血管
CN101688874A (zh) * 2007-07-12 2010-03-31 希森美康株式会社 标本容器
WO2009111622A2 (fr) * 2008-03-05 2009-09-11 Becton, Dickinson And Company Bouchon perforable comoulé et son procédé de fabrication
USD645972S1 (en) 2010-01-25 2011-09-27 Becton, Dickinson And Company Specimen collection container having a label
US8973293B2 (en) 2010-11-19 2015-03-10 Becton, Dickinson And Company Specimen container label for automated clinical laboratory processing systems
US8460620B2 (en) * 2010-12-03 2013-06-11 Becton, Dickinson And Company Specimen collection container assembly
KR101308107B1 (ko) 2011-01-03 2013-09-12 이철문 체액 보관용 보조용기
US9636062B2 (en) 2012-09-06 2017-05-02 Theranos, Inc. Systems, devices, and methods for bodily fluid sample collection
MX368646B (es) 2012-09-06 2019-10-09 Theranos Ip Co Llc Sistemas, dispositivos, y métodos para la recolección de muestras de fluidos corporales.
US9427184B2 (en) 2012-09-06 2016-08-30 Theranos, Inc. Systems, devices, and methods for bodily fluid sample collection
US9386948B2 (en) 2012-12-05 2016-07-12 Theranos, Inc. Systems, devices, and methods for bodily fluid sample transport
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
CN111366442A (zh) 2013-03-15 2020-07-03 赛拉诺斯知识产权有限责任公司 用于样品收集和样品分离的方法和装置
USD754361S1 (en) 2013-09-06 2016-04-19 Theranos, Inc. Sample container
US10391497B1 (en) * 2013-09-09 2019-08-27 Theranos Ip Company, Llc Devices, methods and systems for reducing sample volume
EP3116464B1 (fr) 2014-03-12 2022-06-08 Labrador Diagnostics LLC Dispositifs de collecte d'échantillon de liquide corporel
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
WO2017044888A1 (fr) 2015-09-09 2017-03-16 Theranos, Inc. Procédés et dispositifs de collecte et de séparation d'échantillons
WO2017218848A1 (fr) * 2016-06-15 2017-12-21 Michael Hopkins Système de seringue et procédé d'administration de fluides multiples.
US11857966B1 (en) 2017-03-15 2024-01-02 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
JP6806268B2 (ja) * 2017-12-01 2021-01-06 株式会社島津製作所 液体クロマトグラフ分析システム

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2439218A1 (de) 1974-08-16 1976-02-26 Sarstedt Kunststoff Kapillargefaess zur blutentnahme
GB2017911A (en) * 1978-04-03 1979-10-10 Du Pont Apparatus for extracting component from sample fluid
EP0072006B1 (fr) 1981-08-10 1986-02-19 Becton Dickinson and Company Collecteur de sang pour récipient de microcollection
US5038958A (en) * 1990-03-02 1991-08-13 Norfolk Scientific, Inc. Vented microscale centrifuge tube
US5038794A (en) 1987-11-16 1991-08-13 Valkenburg Nanci L Van Capillary blood collector and method
EP0643944A1 (fr) * 1993-09-22 1995-03-22 B. Braun Melsungen Ag Dispositif de prélèvement de sang
US5458854A (en) 1993-05-12 1995-10-17 Becton, Dickinson And Company Collection assembly
EP0517119B1 (fr) 1991-06-06 1995-11-22 Becton, Dickinson and Company Tube pour collecter une petite quantité de sang
US5556599A (en) * 1992-06-29 1996-09-17 Ahmed; Syed M. Blood sample/fluid system

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US4411163A (en) * 1981-07-27 1983-10-25 American Hospital Supply Corporation Ventable sample collection device
DE3541041A1 (de) * 1985-11-19 1987-05-21 Sarstedt Kunststoff Blutsammelgefaess
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DE3843610A1 (de) * 1988-01-13 1989-07-27 Stephan Dr Diekmann Trenn- oder reaktionssaeuleneinheit
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Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2439218A1 (de) 1974-08-16 1976-02-26 Sarstedt Kunststoff Kapillargefaess zur blutentnahme
GB2017911A (en) * 1978-04-03 1979-10-10 Du Pont Apparatus for extracting component from sample fluid
EP0072006B1 (fr) 1981-08-10 1986-02-19 Becton Dickinson and Company Collecteur de sang pour récipient de microcollection
US5038794A (en) 1987-11-16 1991-08-13 Valkenburg Nanci L Van Capillary blood collector and method
US5038958A (en) * 1990-03-02 1991-08-13 Norfolk Scientific, Inc. Vented microscale centrifuge tube
EP0517119B1 (fr) 1991-06-06 1995-11-22 Becton, Dickinson and Company Tube pour collecter une petite quantité de sang
US5556599A (en) * 1992-06-29 1996-09-17 Ahmed; Syed M. Blood sample/fluid system
US5458854A (en) 1993-05-12 1995-10-17 Becton, Dickinson And Company Collection assembly
EP0643944A1 (fr) * 1993-09-22 1995-03-22 B. Braun Melsungen Ag Dispositif de prélèvement de sang

Also Published As

Publication number Publication date
JP2000506419A (ja) 2000-05-30
EP0877652A1 (fr) 1998-11-18
AU5308798A (en) 1998-06-10
CA2241792C (fr) 2006-11-07
JP3853374B2 (ja) 2006-12-06
US6056925A (en) 2000-05-02
DE19647673A1 (de) 1998-05-28
PL327663A1 (en) 1998-12-21
CA2241792A1 (fr) 1998-05-28
ES2283030T3 (es) 2007-10-16
PL185194B1 (pl) 2003-03-31
ATE350165T1 (de) 2007-01-15
AU719213B2 (en) 2000-05-04
EP0877652B1 (fr) 2007-01-03
DE59712791D1 (de) 2007-02-15
DE19647673C2 (de) 2000-08-24

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