WO1998018448A1 - Utilisation de polyethylene glycol-9 nonylphenylether - Google Patents

Utilisation de polyethylene glycol-9 nonylphenylether Download PDF

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Publication number
WO1998018448A1
WO1998018448A1 PCT/AT1997/000233 AT9700233W WO9818448A1 WO 1998018448 A1 WO1998018448 A1 WO 1998018448A1 AT 9700233 W AT9700233 W AT 9700233W WO 9818448 A1 WO9818448 A1 WO 9818448A1
Authority
WO
WIPO (PCT)
Prior art keywords
polyethylene glycol
nonylphenyl ether
support body
use according
sponge
Prior art date
Application number
PCT/AT1997/000233
Other languages
German (de)
English (en)
Inventor
Wolfgang Knogler
Original Assignee
Notax Holding Gesellschaft Mbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Notax Holding Gesellschaft Mbh filed Critical Notax Holding Gesellschaft Mbh
Priority to DE19781197T priority Critical patent/DE19781197D2/de
Priority to AU47662/97A priority patent/AU4766297A/en
Publication of WO1998018448A1 publication Critical patent/WO1998018448A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants

Definitions

  • the invention describes the use of polyethylene glycol - 9 nonylphenyl ether.
  • the present invention has for its object to improve the effect as a spermicide and the immune system of the vaginal mucosa.
  • the object of the invention is achieved by the features in the characterizing part of claim 1. It is now advantageous that the use of polyethylene glycol-9 nonylphenyl ether in liquid form allows an adhesive coating to be achieved in a simple manner, which coating can be regarded as an artificial chemical condom.
  • a protective function e.g. in the male limb, which are infected with microorganisms, e.g. Viruses, bacteria, clamydia and others like the Herpex Simplex Virus prevented.
  • a foam-shaped support body or a conventional tampon e.g.
  • the liquid environment of the mucous membrane of this agent can be absorbed and distributed more quickly by inserting the foam-shaped support body with this agent in liquid form into the vagina or the posterior vaginal vault, as a result of which the effectiveness occurs more rapidly over a larger surface .
  • a further development according to claim 2 is also advantageous, since this additionally increases the effectiveness of the polyethylene glycol-9 nonylphenyl ether due to the pH-related environment, triggered by the lactic acid.
  • the mixture according to claim 3 favors the build-up of the natural bacterial colonization of the vagina.
  • the effectiveness of the agent is favored by further training according to claim 4.
  • the further embodiment according to claim 5 also makes it possible for the various ingredients to take effect immediately after the insertion of the support body, as a result of which the advantageous protective action begins immediately after the insertion of the support body into the vagina.
  • An embodiment according to claim 6 is advantageous since the high elasticity and the materials used enable good compatibility with the mucous membranes.
  • the embodiment variant according to claim 7 prevents irritation of the mucous membranes in the vagina.
  • a use according to claim 10 is also advantageous, since a shortening of the vagina and a mechanical closure of the cervical canal can be achieved by inserting the support body in the vaginal vault.
  • a tamponade of the posterior vaginal vault (Fornix) is achieved and other active substances, in particular those of medical hygiene and lubricants, are possible in a simple manner.
  • FIG. 1 shows a male member with a coating according to the invention made of polyethylene glycol-9 nonylphenyl ther
  • FIG. 2 shows a sponge-like support body which, according to the invention, is wetted and / or coated and / or filled with the polyethylene glycol-9 nonylphenyl ether;
  • Fig. 3 shows a sponge-like support body in its inserted into the vagina in the rear vaginal vault.
  • a male member 1 is shown, which is formed with a coating 2 of a liquid with high viscosity or in the pasty state, which contains polyethylene glycol - 9 nonylphenyl ether 3. If the polyethylene glycol 9 nonylphenyl ether 3 is mixed with 2 ml lactic acid 4, the natural bacterial colonization is supported or improved.
  • a mixture of 8 ml of polyethylene glycol-9 nonylphenyl ether 3 is preferably used for a uniform, uniform coating of high adhesion.
  • the lactic acid 4 creates a favorable environment for the surrounding mucous membrane 5 for the action of the polyethylene glycol - 9 nonylphenyl ether 3, in particular a favorable pH value, which supports the build-up of the continuous coating 2 and prevents a too rapid dissolution due to excessive pH differences.
  • the polyethylene glycol-9 nonylphenyl ether 3 can, however, as can also be seen from FIGS. 2 and 3, also be delivered to the mucous membranes, for example the vaginal mucous membranes 7, 8, by a transmitter, for example a supporting body 6.
  • the polyethylene glycol - 9 nonylphenyl ether 3 then acts as a contraceptive and antiviral.
  • the support body 6 usually consists of a plastic foam 9 with predominantly open cells 10.
  • the coating or wetting can also be carried out in such a way that the entire surface of the open cells 10 or the cell framework is coated with this agent or a mixture with this agent, as is shown in another area of the end view of the support body 6 in FIG. 2 is shown.
  • the plastic foam is preferably set to be highly elastic and, at an impression depth of 40%, only requires an impression force of around 20-80 N.
  • a cubic centimeter of the support body 6 or the elastic, soft foam-like support body 6 is preferably coated or impregnated with 3 ml / mg to 5 ml / mg of the polyethylene glycol-9 nonylphenyl ether solution or a mixture thereof.
  • the plastic foam 9 of the support body 6 is preferably formed from a polyurethane prepolymer 12.
  • a density of this plastic foam 9 is preferably less than 8 kg / m ', the plastic foam 9 preferably being predominantly open-celled.
  • a combination is advantageously achieved by the improved sliding, disinfection and cohabitation effect on the support body 6, e.g. a tampon made of any material.
  • the advantage of inserting the supporting body 6 into a sheath 15 is that the sheath 15 is shortened and a mechanical closure of the cervical canal is achieved.
  • the shortening of the vagina 15 also leads to an increase in pleasure in the wearer of the same during sexual intercourse with the support body 6 inserted.
  • a tamponade of a posterior vaginal vault 16 is created, which has a positive effect on the transition of the active substance or mixture of active substances, namely the polyethylene glycol 9 nonylphenyl ether 3.
  • Nonylphenyl ether 3 is usually a colorless liquid that is soluble in water ethanol-ethylene-glycol-dichloride-xylene-grain oil. It has the general formula H3C- (CH2) 8-C6H4-O- (CH2-CH2O) -X- l-CH2-CH2OH. Applied vaginally, this agent has a strong spermicidal effect on human sperm.

Landscapes

  • Health & Medical Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne l'utilisation de polyéthylène glycol-9 nonylphényl éther (3) sous forme liquide pour imprégner et/ou recouvrir de façon durable les muqueuses d'un organe génital, afin de produire une couche chimique sur ledit organe génital, ou bien pour humecter et/ou recouvrir et/ou remplir un substrat (6) du type spongieux, pouvant être introduit dans le vagin, comme contraceptif et virostatique destiné à la muqueuse vaginale.
PCT/AT1997/000233 1996-10-31 1997-10-30 Utilisation de polyethylene glycol-9 nonylphenylether WO1998018448A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19781197T DE19781197D2 (de) 1996-10-31 1997-10-30 Verwendung von Polyäthylenglykol-9-Nonylphenyläther
AU47662/97A AU4766297A (en) 1996-10-31 1997-10-30 Use of polyethylene glycol-9 nonylphenyl ether

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT191096 1996-10-31
ATA1910/96 1996-10-31

Publications (1)

Publication Number Publication Date
WO1998018448A1 true WO1998018448A1 (fr) 1998-05-07

Family

ID=3523675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT1997/000233 WO1998018448A1 (fr) 1996-10-31 1997-10-30 Utilisation de polyethylene glycol-9 nonylphenylether

Country Status (3)

Country Link
AU (1) AU4766297A (fr)
DE (1) DE19781197D2 (fr)
WO (1) WO1998018448A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066900A2 (fr) * 1998-06-23 1999-12-29 Notax Holding Gesellschaft Mbh Utilisation de nonoxynol-9 comme lubrifiant et son procede de production
WO2003092652A1 (fr) * 2002-05-01 2003-11-13 Mcneil-Ppc, Inc. Compositions lubrifiantes anhydres chauffantes et non irritantes
US7285517B2 (en) 2002-05-01 2007-10-23 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7417013B2 (en) 2002-05-01 2008-08-26 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7658941B2 (en) 2002-05-01 2010-02-09 Johnson & Johnson Consumer Companies, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7695730B2 (en) 2002-05-01 2010-04-13 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
WO2014041378A3 (fr) * 2012-09-14 2014-05-30 Cipla Limited Composition pharmaceutique topique
CN112891323A (zh) * 2020-01-22 2021-06-04 首都医科大学附属北京地坛医院 一种抗hiv外用消毒剂及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692143A (en) * 1984-04-09 1987-09-08 Gero Ilona B Unit package containing ready-to-use vaginal contraceptive
DE3714486A1 (de) * 1987-04-30 1988-11-10 Heiny Bernd Michael Dr Med Desinfektionsmittel zur traenkung von hygienetuechern bzw. zur verwendung in sprays
US5244885A (en) * 1991-01-23 1993-09-14 Asta Medica Aktiengesellschaft Camomile extract having antimicrobial properties, process for its manufacture and its use
WO1997045116A1 (fr) * 1996-05-30 1997-12-04 Uniroyal Chemical Company, Inc. Utilisation de derives de thiocarboxanilide pour la preparation de medicaments prevenant la transmission du vih a des cellules non infectees, et compositions contraceptives comprenant lesdits derives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692143A (en) * 1984-04-09 1987-09-08 Gero Ilona B Unit package containing ready-to-use vaginal contraceptive
DE3714486A1 (de) * 1987-04-30 1988-11-10 Heiny Bernd Michael Dr Med Desinfektionsmittel zur traenkung von hygienetuechern bzw. zur verwendung in sprays
US5244885A (en) * 1991-01-23 1993-09-14 Asta Medica Aktiengesellschaft Camomile extract having antimicrobial properties, process for its manufacture and its use
WO1997045116A1 (fr) * 1996-05-30 1997-12-04 Uniroyal Chemical Company, Inc. Utilisation de derives de thiocarboxanilide pour la preparation de medicaments prevenant la transmission du vih a des cellules non infectees, et compositions contraceptives comprenant lesdits derives

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066900A2 (fr) * 1998-06-23 1999-12-29 Notax Holding Gesellschaft Mbh Utilisation de nonoxynol-9 comme lubrifiant et son procede de production
WO1999066900A3 (fr) * 1998-06-23 2000-08-24 Notax Holding Ges Mbh Utilisation de nonoxynol-9 comme lubrifiant et son procede de production
WO2003092652A1 (fr) * 2002-05-01 2003-11-13 Mcneil-Ppc, Inc. Compositions lubrifiantes anhydres chauffantes et non irritantes
US7285517B2 (en) 2002-05-01 2007-10-23 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7417013B2 (en) 2002-05-01 2008-08-26 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7658941B2 (en) 2002-05-01 2010-02-09 Johnson & Johnson Consumer Companies, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7695730B2 (en) 2002-05-01 2010-04-13 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7758887B2 (en) 2002-05-01 2010-07-20 McNeil - PPC Warming and nonirritating lubricant compositions and method of comparing irritation
WO2014041378A3 (fr) * 2012-09-14 2014-05-30 Cipla Limited Composition pharmaceutique topique
CN112891323A (zh) * 2020-01-22 2021-06-04 首都医科大学附属北京地坛医院 一种抗hiv外用消毒剂及其制备方法
CN112891323B (zh) * 2020-01-22 2023-08-18 首都医科大学附属北京地坛医院 一种抗hiv外用消毒剂及其制备方法

Also Published As

Publication number Publication date
AU4766297A (en) 1998-05-22
DE19781197D2 (de) 2000-07-13

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