WO1998007449A3 - Polymere gallensäure-resorptionsinhibitoren mit gleichzeitiger gallensäure-adsorberwirkung - Google Patents

Polymere gallensäure-resorptionsinhibitoren mit gleichzeitiger gallensäure-adsorberwirkung Download PDF

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Publication number
WO1998007449A3
WO1998007449A3 PCT/EP1997/004049 EP9704049W WO9807449A3 WO 1998007449 A3 WO1998007449 A3 WO 1998007449A3 EP 9704049 W EP9704049 W EP 9704049W WO 9807449 A3 WO9807449 A3 WO 9807449A3
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WO
WIPO (PCT)
Prior art keywords
bile acid
simultaneous
polymer
resorption inhibitors
adsorbing effect
Prior art date
Application number
PCT/EP1997/004049
Other languages
English (en)
French (fr)
Other versions
WO1998007449A2 (de
Inventor
Seggern Heinke Von
Werner Kramer
Guenther Wess
Original Assignee
Hoechst Res & Tech Gmbh & Co
Seggern Heinke Von
Werner Kramer
Guenther Wess
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Res & Tech Gmbh & Co, Seggern Heinke Von, Werner Kramer, Guenther Wess filed Critical Hoechst Res & Tech Gmbh & Co
Priority to JP10510319A priority Critical patent/JP2000517356A/ja
Priority to CA002263671A priority patent/CA2263671A1/en
Priority to EP97940028A priority patent/EP0918544A2/de
Publication of WO1998007449A2 publication Critical patent/WO1998007449A2/de
Publication of WO1998007449A3 publication Critical patent/WO1998007449A3/de

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung. Es werden Vinylcopolymere mit Einheiten der Formel (I), worin R?1 bis R5¿, d, e, f, H, L, A, Y, Z und B die angegebenen Bedeutungen haben und ein Verfahren zu deren Herstellung beschrieben. Die Verbindungen eignen sich zur Behandlung von Lipidstoffwechselstörungen.
PCT/EP1997/004049 1996-08-19 1997-07-25 Polymere gallensäure-resorptionsinhibitoren mit gleichzeitiger gallensäure-adsorberwirkung WO1998007449A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP10510319A JP2000517356A (ja) 1996-08-19 1997-07-25 併発胆汁酸吸着作用を有する高分子量胆汁酸吸収阻害剤
CA002263671A CA2263671A1 (en) 1996-08-19 1997-07-25 Polymer bile acid resorption inhibitors with simultaneous bile acid adsorbing effect
EP97940028A EP0918544A2 (de) 1996-08-19 1997-07-25 Polymere gallensäure-resorptionsinhibitoren mit gleichzeitiger gallensäure-adsorberwirkung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19633268.0 1996-08-19
DE19633268A DE19633268A1 (de) 1996-08-19 1996-08-19 Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung

Publications (2)

Publication Number Publication Date
WO1998007449A2 WO1998007449A2 (de) 1998-02-26
WO1998007449A3 true WO1998007449A3 (de) 1998-06-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/004049 WO1998007449A2 (de) 1996-08-19 1997-07-25 Polymere gallensäure-resorptionsinhibitoren mit gleichzeitiger gallensäure-adsorberwirkung

Country Status (5)

Country Link
EP (1) EP0918544A2 (de)
JP (1) JP2000517356A (de)
CA (1) CA2263671A1 (de)
DE (1) DE19633268A1 (de)
WO (1) WO1998007449A2 (de)

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MX2021008981A (es) 2019-02-06 2021-09-08 Albireo Ab Compuestos de benzotiadiazepina y su uso como moduladores del acido biliar.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844822B2 (en) 2014-06-25 2023-12-19 Elobix Ab Solid formulation and method for preventing or reducing coloration thereof

Also Published As

Publication number Publication date
WO1998007449A2 (de) 1998-02-26
CA2263671A1 (en) 1998-02-26
JP2000517356A (ja) 2000-12-26
DE19633268A1 (de) 1998-02-26
EP0918544A2 (de) 1999-06-02

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