WO1997026862A3 - Verbesserte konzentrierte injektions- und infusionslösungen für die intravasale anwendung - Google Patents

Verbesserte konzentrierte injektions- und infusionslösungen für die intravasale anwendung Download PDF

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Publication number
WO1997026862A3
WO1997026862A3 PCT/DE1997/000170 DE9700170W WO9726862A3 WO 1997026862 A3 WO1997026862 A3 WO 1997026862A3 DE 9700170 W DE9700170 W DE 9700170W WO 9726862 A3 WO9726862 A3 WO 9726862A3
Authority
WO
WIPO (PCT)
Prior art keywords
infusion solutions
intravenous administration
concentrated injection
improved concentrated
injection
Prior art date
Application number
PCT/DE1997/000170
Other languages
English (en)
French (fr)
Other versions
WO1997026862A2 (de
Inventor
Ulrich Speck
Gabriele Schuhmann-Giampieri
Peter Muschick
Werner Krause
Original Assignee
Schering Ag
Ulrich Speck
Schuhmann Giampieri Gabriele
Peter Muschick
Werner Krause
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK97914098T priority Critical patent/DK0876140T3/da
Priority to EP97914098A priority patent/EP0876140B1/de
Application filed by Schering Ag, Ulrich Speck, Schuhmann Giampieri Gabriele, Peter Muschick, Werner Krause filed Critical Schering Ag
Priority to SK1013-98A priority patent/SK101398A3/sk
Priority to BR9707081A priority patent/BR9707081A/pt
Priority to IL12467697A priority patent/IL124676A0/xx
Priority to AU21504/97A priority patent/AU2150497A/en
Priority to CA002244209A priority patent/CA2244209C/en
Priority to AT97914098T priority patent/ATE251893T1/de
Priority to DE59710863T priority patent/DE59710863D1/de
Priority to PL97328199A priority patent/PL328199A1/xx
Priority to JP9526441A priority patent/JP2000505789A/ja
Publication of WO1997026862A2 publication Critical patent/WO1997026862A2/de
Publication of WO1997026862A3 publication Critical patent/WO1997026862A3/de
Priority to BG102644A priority patent/BG62913B1/bg
Priority to NO983438A priority patent/NO983438L/no
Priority to US09/504,108 priority patent/US6638913B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Es werden Zusätze zu konzentrierten Injektions- und Infusionslösungen, die akute oder verzögerte Überempfindlichkeitsreaktionen vermeiden oder vermindern sowie Injektions- und Infusionslösungen, die diese Zusätze enthalten, beschrieben.
PCT/DE1997/000170 1996-01-25 1997-01-27 Verbesserte konzentrierte injektions- und infusionslösungen für die intravasale anwendung WO1997026862A2 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE59710863T DE59710863D1 (de) 1996-01-25 1997-01-27 Verbesserte kontrastmittenlösungen für die intravasale anwendung
AT97914098T ATE251893T1 (de) 1996-01-25 1997-01-27 Verbesserte kontrastmittenlösungen für die intravasale anwendung
SK1013-98A SK101398A3 (en) 1996-01-25 1997-01-27 Improved concentrated injection and infusion solutions for intravenous administration
EP97914098A EP0876140B1 (de) 1996-01-25 1997-01-27 Verbesserte kontrastmittenlösungen für die intravasale anwendung
IL12467697A IL124676A0 (en) 1996-01-25 1997-01-27 Improved concentrated injection and infusion solutions for intravenous use
AU21504/97A AU2150497A (en) 1996-01-25 1997-01-27 Improved concentrated injection and infusion solutions for intravenous adminis tration
PL97328199A PL328199A1 (en) 1996-01-25 1997-01-27 Improved concentrated intravascular injection and infusion solutions
DK97914098T DK0876140T3 (da) 1996-01-25 1997-01-27 Forbedrede kontrastmiddelopløsninger til intravasal anvendelse
BR9707081A BR9707081A (pt) 1996-01-25 1997-01-27 Soluções de injeção e infusão concentradas aperfeiçoadas para aplicação intravasal
CA002244209A CA2244209C (en) 1996-01-25 1997-01-27 Improved concentrated injection and infusion solutions for intravenous administration
JP9526441A JP2000505789A (ja) 1996-01-25 1997-01-27 注射及び輸液用として血管内に使用する改良された濃縮溶液
BG102644A BG62913B1 (bg) 1996-01-25 1998-07-21 Подобрени концентрирани инжекционни и инфузионни разтвори за интравазално прилагане
NO983438A NO983438L (no) 1996-01-25 1998-07-24 Forbedrede konsentrerte injeksjons- og infusjonsl°sninger for intravasal anvendelse
US09/504,108 US6638913B1 (en) 1996-01-25 2000-02-14 Concentrated injection and infusion solution for intravenous administration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19604095 1996-01-25
DE19604095.7 1996-01-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/504,108 Division US6638913B1 (en) 1996-01-25 2000-02-14 Concentrated injection and infusion solution for intravenous administration

Publications (2)

Publication Number Publication Date
WO1997026862A2 WO1997026862A2 (de) 1997-07-31
WO1997026862A3 true WO1997026862A3 (de) 1997-10-23

Family

ID=7784538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1997/000170 WO1997026862A2 (de) 1996-01-25 1997-01-27 Verbesserte konzentrierte injektions- und infusionslösungen für die intravasale anwendung

Country Status (21)

Country Link
US (1) US6638913B1 (de)
EP (1) EP0876140B1 (de)
JP (1) JP2000505789A (de)
KR (1) KR100505772B1 (de)
CN (1) CN1209751A (de)
AT (1) ATE251893T1 (de)
AU (1) AU2150497A (de)
BG (1) BG62913B1 (de)
BR (1) BR9707081A (de)
CA (1) CA2244209C (de)
CZ (1) CZ234898A3 (de)
DE (2) DE19703816A1 (de)
DK (1) DK0876140T3 (de)
ES (1) ES2208884T3 (de)
HU (1) HUP9901355A3 (de)
IL (1) IL124676A0 (de)
NO (1) NO983438L (de)
PL (1) PL328199A1 (de)
PT (1) PT876140E (de)
SK (1) SK101398A3 (de)
WO (1) WO1997026862A2 (de)

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US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
EP0996461B1 (de) 1997-10-31 2005-01-12 Walter Reed Army Institute of Research Verwendung von inhibitoren der komplementaktivierung zur herstellung eines medikaments zur inhibierung von nebenwirkungen von pharmazeutischen zusammensetzungen, die amphiphile träger oder wirkstoffträger moleküle enthalten
JP4334766B2 (ja) 1998-04-01 2009-09-30 カーディオム ファーマ コーポレイション アミノシクロヘキシルエーテル化合物およびその用途
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7524879B2 (en) 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US8703126B2 (en) 2000-10-12 2014-04-22 Genentech, Inc. Reduced-viscosity concentrated protein formulations
IL155002A0 (en) 2000-10-12 2003-10-31 Genentech Inc Reduced-viscosity concentrated protein formulations
DE10115740A1 (de) 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
US20020169112A1 (en) * 2001-05-08 2002-11-14 Luc Montagnier Combined treatments and methods for treatment of mycoplasma and mycoplasma-like organism infections
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
DK1560812T3 (da) 2003-05-02 2006-09-04 Cardiome Pharma Corp Aminocyclohexyletherforbindelser og anvendelser deraf
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US8058304B2 (en) 2004-04-01 2011-11-15 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
WO2005113011A2 (en) 2004-04-01 2005-12-01 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
WO2006053037A2 (en) 2004-11-08 2006-05-18 Cardiome Pharma Corp. A new dosing regimen for ion channel modulating compounds for treating acute atrial fibrillation in a human
US20060270708A1 (en) * 2005-05-25 2006-11-30 Navinta Llc Novel process for preparation of isotonic aqueous injection of ropivacaine
EP1897535A1 (de) * 2006-08-30 2008-03-12 Dirinco AG Substitutionsflüssigkeit für die Haemofiltration
US20090239894A1 (en) * 2008-03-20 2009-09-24 Bjorn Schurad Stabilized aqueous solutions of ergoline compounds
BRPI1006519A2 (pt) 2009-03-06 2016-08-09 Genentech Inc formulação de anticorpos
US10634741B2 (en) 2009-12-04 2020-04-28 Endomagnetics Ltd. Magnetic probe apparatus
US9427186B2 (en) * 2009-12-04 2016-08-30 Endomagnetics Ltd. Magnetic probe apparatus
SG10201903166PA (en) 2010-03-01 2019-05-30 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
CN102319258B (zh) * 2011-08-04 2012-10-31 山西诺成制药有限公司 一种5%葡萄糖置换液及其制备方法
US8613919B1 (en) 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
AU2014229811B2 (en) 2013-03-11 2018-02-15 Endomagnetics Ltd. Hypoosmotic solutions for lymph node detection
US9234877B2 (en) 2013-03-13 2016-01-12 Endomagnetics Ltd. Magnetic detector
US9239314B2 (en) 2013-03-13 2016-01-19 Endomagnetics Ltd. Magnetic detector
KR20150134346A (ko) * 2013-03-27 2015-12-01 지이 헬스케어 에이에스 진단 조성물을 제조하기 위한 방법 및 시약
KR102589814B1 (ko) 2015-06-04 2023-10-13 엔도마그네틱스 엘티디 자성 표지자 위치 결정(ｍｍｌ)을 위한 표지자 재료 및 형태
CA3097061A1 (en) * 2018-04-16 2019-10-24 Merck Patent Gmbh Viscosity reduction of highly concentrated protein formulations
CN110327292A (zh) * 2019-08-11 2019-10-15 天津乾丰瑞科技有限公司 一种盐酸法舒地尔注射制剂及其制备方法

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FR2435253A1 (fr) * 1978-07-04 1980-04-04 Nyegaard & Co As Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procede
EP0260811A2 (de) * 1986-08-21 1988-03-23 Vestar, Inc. Phospholipidpartikeln mit eingeschlossenen Polyen-Antibiotika zur Behandlung von systemischen Pilzinfektionen
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EP0437622A1 (de) * 1989-07-07 1991-07-24 Kyowa Hakko Kogyo Co., Ltd. Beständige motilin-herstellung

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Publication number Priority date Publication date Assignee Title
FR2435253A1 (fr) * 1978-07-04 1980-04-04 Nyegaard & Co As Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procede
EP0260811A2 (de) * 1986-08-21 1988-03-23 Vestar, Inc. Phospholipidpartikeln mit eingeschlossenen Polyen-Antibiotika zur Behandlung von systemischen Pilzinfektionen
WO1989009614A1 (en) * 1988-04-15 1989-10-19 Genentech, Inc. Human growth hormone formulation
EP0437622A1 (de) * 1989-07-07 1991-07-24 Kyowa Hakko Kogyo Co., Ltd. Beständige motilin-herstellung

Also Published As

Publication number Publication date
IL124676A0 (en) 1998-12-06
US6638913B1 (en) 2003-10-28
KR100505772B1 (ko) 2005-10-25
BG62913B1 (bg) 2000-11-30
SK101398A3 (en) 1998-12-02
DE59710863D1 (de) 2003-11-20
CZ234898A3 (cs) 1998-11-11
EP0876140A2 (de) 1998-11-11
CA2244209C (en) 2007-10-23
PL328199A1 (en) 1999-01-18
DK0876140T3 (da) 2003-12-15
ES2208884T3 (es) 2004-06-16
JP2000505789A (ja) 2000-05-16
DE19703816A1 (de) 1997-08-07
CA2244209A1 (en) 1997-07-31
EP0876140B1 (de) 2003-10-15
HUP9901355A3 (en) 2000-06-28
PT876140E (pt) 2004-02-27
BR9707081A (pt) 1999-05-25
WO1997026862A2 (de) 1997-07-31
BG102644A (en) 1999-06-30
NO983438D0 (no) 1998-07-24
HUP9901355A2 (hu) 1999-08-30
CN1209751A (zh) 1999-03-03
AU2150497A (en) 1997-08-20
ATE251893T1 (de) 2003-11-15
KR19990081979A (ko) 1999-11-15
NO983438L (no) 1998-09-18

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