WO1996029062A1 - Feuille produisant du froid - Google Patents

Feuille produisant du froid Download PDF

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Publication number
WO1996029062A1
WO1996029062A1 PCT/JP1995/000526 JP9500526W WO9629062A1 WO 1996029062 A1 WO1996029062 A1 WO 1996029062A1 JP 9500526 W JP9500526 W JP 9500526W WO 9629062 A1 WO9629062 A1 WO 9629062A1
Authority
WO
WIPO (PCT)
Prior art keywords
water
ethanol
menthol
weight
plaster
Prior art date
Application number
PCT/JP1995/000526
Other languages
English (en)
Japanese (ja)
Inventor
Akihito Oji
Takashi Mizobuchi
Original Assignee
Teikoku Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Seiyaku Kabushiki Kaisha filed Critical Teikoku Seiyaku Kabushiki Kaisha
Priority to JP52826796A priority Critical patent/JP3908275B2/ja
Priority to GB9624252A priority patent/GB2302651B/en
Priority to PCT/JP1995/000526 priority patent/WO1996029062A1/fr
Publication of WO1996029062A1 publication Critical patent/WO1996029062A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/10—Cooling bags, e.g. ice-bags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug

Definitions

  • the present invention relates to a cold-sensitive patch called a cold sheet, and more specifically, to a paste composition containing a water-soluble polymer substance, a polyhydric alcohol and water, which provides a cooling effect by mixing menthol and ethanol.
  • the present invention relates to a patch whose cooling effect lasts for a long time.
  • patches have been commonly used for local inflammation accompanied by fever such as bruising and sprains, to suppress blood flow at the site of inflammation and relieve pain.
  • Patches that satisfy this purpose of use include, in addition to physical properties such as good adhesion to the skin and no plaster remaining when removed from the skin, a particularly high cooling effect and a long-lasting cooling effect What can be done is desirable.
  • JP-A-54-106598, JP-A-59-110615 which utilizes the heat of vaporization generated when water evaporates to enhance the cooling effect of the affected part. Have been. This is preserved due to the large amount of water in the base. During periods of poor formation and sweating in large quantities, such as in summer, the plaster becomes excessively moist due to the sweat on the affected area, causing so-called dripping and sticking phenomena. In addition, since it is difficult to incorporate a humectant such as glycerin or propylene glycol, water is volatilized within a short time, and the cooling effect is not maintained.
  • a humectant such as glycerin or propylene glycol
  • the present inventors have conducted intensive studies in order to avoid the above-mentioned drawbacks, and as a result, a fixed ratio of menthol and ethanol was added to a sound body composition containing a water-soluble polymer substance, a polyhydric alcohol and water. The inventor has found that the blending can maintain the cooling effect for a long time, thereby completing the present invention.
  • the patch of the present invention is characterized in that a menthol and an ethanol as a cooling sensation-imparting component are blended in a specific ratio to a plaster composition containing a water-soluble polymer substance, a polyhydric alcohol and water. is there.
  • the water-soluble polymer substance referred to in the present invention specifically includes gelatin, polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, carboxymethylcellulose sodium, and hydroxypropyl.
  • gelatin polyacrylic acid
  • sodium polyacrylate polyvinyl alcohol
  • polyvinylpyrrolidone polyvinyl polymer
  • carboxymethylcellulose sodium and hydroxypropyl.
  • the amount of these water-soluble polymer substances is not particularly limited, but if it is less than 2% (% by weight, hereinafter the same) of the total amount of the blue body composition, sufficient viscosity cannot be obtained and the paste does not form. On the other hand, if it is more than 20%, the viscosity becomes high, which may cause a problem in workability during production. Therefore, this water-soluble polymer substance is blended at 2 to 20%, preferably 5 to 15%, based on the total amount of the breeding composition.
  • the polyhydric alcohol in the present invention include one or a mixture of two or more of glycerin, sorbitol, propylene glycol, polyethylene glycol, 1,3-butylene glycol, ethylene glycol, and the like.
  • These compounded children are selected from the range of 8 to 60%, preferably 10 to 50% based on the total amount of the plaster composition. If it is less than 8%, the moisturizing effect will not be sufficient, and water will disperse in a short time, and the effect of mixing menthol and ethanol, that is, the cooling effect will not be maintained. On the other hand, if it is 60% or more, it becomes difficult to incorporate other components.
  • Water is usually in the range of 20 to 80%, preferably 25 to 70%, based on the total amount of the plaster composition. If it is less than 20%, the dissolution of the water-soluble polymer becomes insufficient, and it becomes impossible to spread uniformly. On the other hand, if it exceeds 80%, the plaster may deteriorate and sag.
  • the blending ratio of menthol to ethanol blended with the above-mentioned malformed composition comprising the water-soluble polymer substance, polyhydric alcohol and water is preferably 1: 0.5 to 1:10 by weight ratio, more preferably. Is 1: 1 to 1: 5 and the cooling effect will not be sustained if it deviates from this range.
  • the mixing amount of ethanol is preferably 0.1 to 10% based on the total amount of the plaster composition. If ethanol is added at 10% or more, skin irritation tends to occur at the application site, and if it is 0.1% or less, the cooling effect is not exhibited.
  • plaster composition of the present invention in addition to the above-mentioned components, various additives used in ordinary patches, for example, inorganic substances such as dextrin, bentonite, titanium oxide, etc., surfactants and citrus agents are usually used. Can be blended.
  • inorganic substances such as dextrin, bentonite, titanium oxide, etc.
  • surfactants and citrus agents are usually used. Can be blended.
  • the plaster composition of the present invention is prepared by kneading each component by a usual method. For example, one part of a water-soluble polymer and a polyhydric alcohol are dissolved in water, and if necessary, other additives are added thereto. The mixture is kneaded by adding a water solution and kneading, and further kneading by adding the remaining water-soluble polymer substance and other additives.
  • the plaster composition thus prepared is applied and spread on a base fabric by a conventional method, and a release paper is stuck on the surface for protection, and then cut into a predetermined size to obtain a desired size. Obtain a patch.
  • the base fabric all nonwoven fabrics, woven fabrics, knitted fabrics and the like used in ordinary patches are used, and the material may be any of synthetic fibers such as nylon, rayon, polyester, and polypropylene, and natural fibers.
  • the release paper all those used for plastic films such as polyethylene films and other ordinary patches are used.
  • Gelatin and polyvinyl alcohol are added to 15 parts of purified water and dissolved by heating. Methyl paraben is added to this solution and kneaded well. Next, a solution prepared by dissolving menthol in ethanol, tartaric acid, and the remaining portion of purified water are added and further kneaded until uniform. Finally, a solution in which polyacrylic acid, sodium polyacrylate, sodium carboxymethylcellulose, and aluminum hydroxide are dispersed in glycerin is added, and the mixture is sufficiently kneaded to obtain a plaster. The resulting plaster of the base fabric made of rayon O ⁇ , 1 0 0 O g was spread so that / m 2 was attached to a plastic Fi Lum on year plaster surface, and cut into a predetermined size Obtain a patch.
  • Gelatin and polyvinylpyrrolidone are added to 15 parts of purified water and dissolved by heating. To this solution, add methylparaben and propylparaben and knead well. Next, add a solution of £ 1 menthol in ethanol, tartaric acid, kaolin, D-sorbitol solution, and the remaining portion of purified water, and further knead until uniform. Finally, a solution in which sodium polyacrylate, sodium carboxymethylcellulose, and aluminum hydroxide are dispersed in glycerin is added, and the mixture is thoroughly kneaded to obtain descendants.
  • the resulting plaster of the base fabric consisting of polyester fibers, and spread so that 1 0 0 0 g / m 2 , and affixed ⁇ paper on the plaster surface, and the cross-sectional Court to a predetermined size Obtain a patch.
  • Gelatin and polyvinyl alcohol are added to 15 parts of purified water and dissolved by heating. To this solution, add methylparaben and propylparaben and knead well. Next, a solution of menthol dissolved in ethanol and the remainder of the water production are added and further kneaded until uniform. Lastly, a solution in which polyacryloleic acid, sodium polyacrylate, sodium alginate, and magnesium aluminate are dispersed in a mixture of glycerin and propylene glycol is added and sufficiently kneaded to obtain a plaster. The obtained plaster is spread on a base cloth made of nylon fiber so as to have a thickness of 100 Og / m 2, and a release paper is attached to the surface of the blue body, cut into a predetermined size, and a patch is prepared. Get.
  • Example 1 From the components of Example 1, menthol was removed, and instead, the same amount of water was added to obtain a patch by the same method.
  • Ethanol is removed from the components of Example 1, and the same amount of liquid menthol in terms of monomenthol is added instead of menthol, and a patch is obtained in the same manner.
  • Cooling effect The cooling sensation at the time of application is evaluated according to the following criteria.
  • ⁇ Cooling persistence Evaluated by the subject declaring the duration of the cooling effect.
  • the patch according to the present invention has excellent properties in terms of the sustained cooling effect time by adding menthol and ethanol to a plaster composition containing a water-soluble polymer substance. It was found to have

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compresse produisant du froid de manière exceptionnellement persistante, que l'on produit en ajoutant du l-menthol et de l'éthanol à une composition de pansement contenant un substance hydrosoluble à masse molaire élevée, un polyol et de l'eau selon un rapport de 1/0,5 à 1/10.
PCT/JP1995/000526 1995-03-22 1995-03-22 Feuille produisant du froid WO1996029062A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP52826796A JP3908275B2 (ja) 1995-03-22 1995-03-22 コールドシート
GB9624252A GB2302651B (en) 1995-03-22 1995-03-22 Cold sheet
PCT/JP1995/000526 WO1996029062A1 (fr) 1995-03-22 1995-03-22 Feuille produisant du froid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1995/000526 WO1996029062A1 (fr) 1995-03-22 1995-03-22 Feuille produisant du froid

Publications (1)

Publication Number Publication Date
WO1996029062A1 true WO1996029062A1 (fr) 1996-09-26

Family

ID=14125793

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1995/000526 WO1996029062A1 (fr) 1995-03-22 1995-03-22 Feuille produisant du froid

Country Status (3)

Country Link
JP (1) JP3908275B2 (fr)
GB (1) GB2302651B (fr)
WO (1) WO1996029062A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072665A1 (fr) * 2004-01-30 2005-08-11 Kobayashi Pharmaceutical Co., Ltd. Composition d’agent de refroidissement
WO2010038804A1 (fr) * 2008-09-30 2010-04-08 小林製薬株式会社 Agent conférant du froid pour vêtements
JP4979830B1 (ja) * 2011-11-10 2012-07-18 重憲 青木 無痛注射用外用剤
JP2012197300A (ja) * 2005-01-04 2012-10-18 Teikoku Pharma Usa Inc 冷却局所用貼付製剤
JP2018083069A (ja) * 2016-11-11 2018-05-31 小林製薬株式会社 身体貼付用冷却組成物、及びそれを使用した身体冷却用貼付剤
JP2020066592A (ja) * 2018-10-24 2020-04-30 帝國製薬株式会社 水性貼付剤

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1420732A4 (fr) * 2000-12-11 2009-05-13 Young-Whan Yu Produit refroidissant portable
EP1685837A4 (fr) * 2003-11-12 2009-03-25 Lead Chem Co Ltd Agent protecteur cerebral du type administre par absorption percutanee
FR2880262B1 (fr) * 2005-01-03 2013-11-08 Oreal Article cosmetique ou dermatologique comportant un support soluble dans l'eau
FR2894135B1 (fr) * 2005-12-07 2008-09-12 Oreal Article cosmetique soluble a effet thermique
US7910121B2 (en) 2005-12-07 2011-03-22 L'oreal Soluble cosmetic article with a thermal effect
US8460352B2 (en) 2006-07-05 2013-06-11 Kaz Usa, Inc. Site-specific pad with notch
US8252199B2 (en) 2009-07-28 2012-08-28 Jacob Technology Product 1, SL Coolant composition
ES2628893T3 (es) * 2011-01-24 2017-08-04 Jacob Technology Product 1, S. L. Composición refrigerante
CN105531305A (zh) 2013-09-30 2016-04-27 金伯利-克拉克环球有限公司 具有热活性剂的热塑性制品
WO2015061829A1 (fr) * 2013-10-30 2015-05-07 Magna Carta Pty Ltd Solution rafraîchissante et procédés d'utilisation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5545626A (en) * 1978-09-26 1980-03-31 Lion Corp Poultice
JPS5927821A (ja) * 1982-08-06 1984-02-14 Kanebo Ltd バツプ剤
JPS63135328A (ja) * 1986-11-27 1988-06-07 Kao Corp 貼付剤組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5545626A (en) * 1978-09-26 1980-03-31 Lion Corp Poultice
JPS5927821A (ja) * 1982-08-06 1984-02-14 Kanebo Ltd バツプ剤
JPS63135328A (ja) * 1986-11-27 1988-06-07 Kao Corp 貼付剤組成物

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072665A1 (fr) * 2004-01-30 2005-08-11 Kobayashi Pharmaceutical Co., Ltd. Composition d’agent de refroidissement
JP2012197300A (ja) * 2005-01-04 2012-10-18 Teikoku Pharma Usa Inc 冷却局所用貼付製剤
WO2010038804A1 (fr) * 2008-09-30 2010-04-08 小林製薬株式会社 Agent conférant du froid pour vêtements
JP2010084269A (ja) * 2008-09-30 2010-04-15 Kobayashi Pharmaceut Co Ltd 衣類用冷感付与剤
JP4979830B1 (ja) * 2011-11-10 2012-07-18 重憲 青木 無痛注射用外用剤
WO2013069339A1 (fr) * 2011-11-10 2013-05-16 Aoki Shigenori Préparation externe soulageant la douleur au site d'injection
JP2018083069A (ja) * 2016-11-11 2018-05-31 小林製薬株式会社 身体貼付用冷却組成物、及びそれを使用した身体冷却用貼付剤
JP2020066592A (ja) * 2018-10-24 2020-04-30 帝國製薬株式会社 水性貼付剤

Also Published As

Publication number Publication date
JP3908275B2 (ja) 2007-04-25
GB2302651A (en) 1997-01-29
GB9624252D0 (en) 1997-01-08
GB2302651B (en) 1999-07-28

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