WO1995023783A1 - Cetopanthenol presentant des proprietes acetylantes - Google Patents

Cetopanthenol presentant des proprietes acetylantes Download PDF

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Publication number
WO1995023783A1
WO1995023783A1 PCT/RU1995/000033 RU9500033W WO9523783A1 WO 1995023783 A1 WO1995023783 A1 WO 1995023783A1 RU 9500033 W RU9500033 W RU 9500033W WO 9523783 A1 WO9523783 A1 WO 9523783A1
Authority
WO
WIPO (PCT)
Prior art keywords
formula
panel
sulfacyl
ketopanthenol
group
Prior art date
Application number
PCT/RU1995/000033
Other languages
English (en)
Russian (ru)
Inventor
Galina Sergeevna Kozlova
Olga Ivanovna Semina
Vladimir Ivanovich Gunar
Jury Fedorovich Krylov
Original Assignee
Tovarischestvo S Ogranichennoi Otvetstvennostju 'pant'
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tovarischestvo S Ogranichennoi Otvetstvennostju 'pant' filed Critical Tovarischestvo S Ogranichennoi Otvetstvennostju 'pant'
Priority to JP7522848A priority Critical patent/JPH09511234A/ja
Priority to EP95912527A priority patent/EP0748793A1/fr
Publication of WO1995023783A1 publication Critical patent/WO1995023783A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the potent acid (vitamin ⁇ 3 or ⁇ 5 ) is available in the form of ⁇ , 1 - and ⁇ (+) potassium calcium.
  • Biologically active is only ⁇ -pantothenic acid and its salts. Calcium is produced for medicine and the food industry.
  • the product contains less than 50% of the active material and is used for vitaminization of the livestock.
  • the cost of vitamin in the S-group is 3 times higher than the cost of the drug in the Russian Federation.
  • Hydrogen acid in the body of the Republic of Ecuador exhibits biological activity, being in the process of the ⁇ ( ⁇ ⁇ ⁇ ) component, it is a valuable game
  • ⁇ Synthesis of the ⁇ -panel is used by the,-panel, which is used in world 5 practice and makes various methods from the synthetic. All of the known methods of receiving ⁇ -panels are subject to many multistage processes with high costs of raw materials, processors, energy and power. This process is the most profitable, sharing the economy of 0 products of vitamin.
  • the synthesizer is synthesized by means of a compensation of a keto-panel with a 3-aminopropyl alcohol in the environment of lower aliphatic systems or without separators. What are you?
  • the controller has a formula (1)
  • test panel has been proven with the help of these elemental analysis and I-spectra. 5
  • the viability of the organism of the vitamin is shared through the study of the reaction of acetylated aromatic amines.
  • the total acetylating capacity of the organism was evaluated by the method of quantitatively distributing the arylamine content in the studied substance (urine).
  • Example 4 5 In the quality of the process of acetylation, a sulphacylate was selected.
  • the average weight of animals in the group was varied in the range of 154.7 + - 10.8 g, the 5th absolute dose of sulfacyl sodium was 3.09 + -0.14 mg.
  • the restoring ability of the body under the influence of the keto-panel5 increased by 1.5 times as compared to the by-product of calcium and by 3.6 times as compared with the carbon.
  • mice of this group received a single inside, only 0.2 ml of distilled water. Mice were monitored for 14 days.
  • mice that received the ketanel starting with a dose of 22.0 g / kg immediately after the introduction of the substance, were slow-moving, they experienced rapid breathing, lethargy, and narrowing of the palpebral fissures. The rate of livelihood decreased by 1-2 days after the introduction of the drug.
  • the maximum transferable dose showed a dose of 21, 0 g / kg of weight, just like for the panel.
  • ketopanthenol U 5 ⁇ - 23.5 g / kg, ⁇ LEu ⁇ - 25.0 g / kg.
  • the experiment which was introduced for 2 months, served as an experienced living non-linear white dishes of a casual environment of a average mass of 75 + -3.3 g.
  • the first groups and groups received daily an experiment in 0.2 ml of distilled water ketogen in the dose of 13.2 mg / kg (in combination with a dose of 26 mg) 20 times more therapist). Then - and the best features were obtained under the same conditions ⁇ and doses of ⁇ -panel (for comparison).
  • the lively seventh group served as a counter, receiving daily 0.2 ml of distilled water inside.
  • a single cortical panel was stored for five days at a weight of 2.5 kg + -0.3 in the conjunctival sac of the eye. No other friendship was found at all.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

On a synthétisé un nouveau composé (le cétopanthénol) présentant la structure (1). Le composé revendiqué est obtenu à partir de la réaction entre une cétopantolactone et un 3-aminopropanol. On a démontré que le cétopanthénol présente un niveau élevé d'activité vitaminique et peut être utilisé en médecine, dans l'élevage de bétail et dans les cosmétiques.
PCT/RU1995/000033 1994-03-02 1995-02-24 Cetopanthenol presentant des proprietes acetylantes WO1995023783A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP7522848A JPH09511234A (ja) 1994-03-02 1995-02-24 アセチル化特性を有するケトパンテノール
EP95912527A EP0748793A1 (fr) 1994-03-02 1995-02-24 Cetopanthenol presentant des proprietes acetylantes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU94008015 1994-03-02
RU9494008015A RU2054000C1 (ru) 1994-03-02 1994-03-02 Кетопантенол, обладающий ацетилирующей активностью d-пантотената кальция

Publications (1)

Publication Number Publication Date
WO1995023783A1 true WO1995023783A1 (fr) 1995-09-08

Family

ID=20153275

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU1995/000033 WO1995023783A1 (fr) 1994-03-02 1995-02-24 Cetopanthenol presentant des proprietes acetylantes

Country Status (5)

Country Link
EP (1) EP0748793A1 (fr)
JP (1) JPH09511234A (fr)
CA (1) CA2183752A1 (fr)
RU (1) RU2054000C1 (fr)
WO (1) WO1995023783A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11091428B2 (en) * 2016-09-13 2021-08-17 Haplogen Gmbh Antiviral compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2358336A (en) * 1941-08-18 1944-09-19 Parke Davis & Co Preparation of vitamin compositions
CH242152A (de) * 1940-03-07 1946-04-30 E Merck Verfahren zur Herstellung einer Verbindung mit den Wirkungen der Pantothensäure.
CH245584A (de) * 1942-09-29 1946-11-15 Hoffmann La Roche Verfahren zur Herstellung eines kosmetischen Mittels.
GB1170132A (en) * 1966-02-24 1969-11-12 Angeli Inst Spa Esters of d-Pantothenol
GB2135300A (en) * 1983-02-19 1984-08-30 Tanabe Seiyaku Co 4-Aminobutyric acid derivatives and processes for the preparation thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH242152A (de) * 1940-03-07 1946-04-30 E Merck Verfahren zur Herstellung einer Verbindung mit den Wirkungen der Pantothensäure.
US2358336A (en) * 1941-08-18 1944-09-19 Parke Davis & Co Preparation of vitamin compositions
CH245584A (de) * 1942-09-29 1946-11-15 Hoffmann La Roche Verfahren zur Herstellung eines kosmetischen Mittels.
GB1170132A (en) * 1966-02-24 1969-11-12 Angeli Inst Spa Esters of d-Pantothenol
GB2135300A (en) * 1983-02-19 1984-08-30 Tanabe Seiyaku Co 4-Aminobutyric acid derivatives and processes for the preparation thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0748793A4 *

Also Published As

Publication number Publication date
RU2054000C1 (ru) 1996-02-10
EP0748793A4 (fr) 1996-11-08
EP0748793A1 (fr) 1996-12-18
JPH09511234A (ja) 1997-11-11
CA2183752A1 (fr) 1995-09-08

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