WO1995019974A2 - Composes a base de calixarene presentant une activite antibacterienne, antifongique, anticancereuse et anti-vih - Google Patents

Composes a base de calixarene presentant une activite antibacterienne, antifongique, anticancereuse et anti-vih Download PDF

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WO1995019974A2
WO1995019974A2 PCT/IE1995/000008 IE9500008W WO9519974A2 WO 1995019974 A2 WO1995019974 A2 WO 1995019974A2 IE 9500008 W IE9500008 W IE 9500008W WO 9519974 A2 WO9519974 A2 WO 9519974A2
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compound
arene
following
prepared
derivative
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PCT/IE1995/000008
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WO1995019974A3 (fr
WO1995019974B1 (fr
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Stephen J. Harris
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Harris Stephen J
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Publication of WO1995019974B1 publication Critical patent/WO1995019974B1/fr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
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    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
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    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Composés à base de calixarène présentant une activité biologique et notamment antibactérienne, antifongique, anticancéreuse et antivirale. Il s'avère que certains composés présentent une activité anti-VIH. Les composés sont des calixarènes ou oxacalixarènes, des oligomères acycliques de phényle-formol, des dérivés de cyclotrivératrylène, des dérivés cycliques tétramères de résorcinol-aldéhyde appelés composés de Hogberg, et des dérivés cycliques tétramères de pyrogallol-aldéhyde.
PCT/IE1995/000008 1994-01-24 1995-01-24 Composes a base de calixarene presentant une activite antibacterienne, antifongique, anticancereuse et anti-vih WO1995019974A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU15453/95A AU1545395A (en) 1994-01-24 1995-01-24 Calixarene-based compounds having antibacterial, antifungal, anticancer-hiv activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE940057 1994-01-24
IES940057 1994-01-24

Publications (3)

Publication Number Publication Date
WO1995019974A2 true WO1995019974A2 (fr) 1995-07-27
WO1995019974A3 WO1995019974A3 (fr) 1995-09-21
WO1995019974B1 WO1995019974B1 (fr) 1995-11-16

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ID=11040267

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PCT/IE1995/000008 WO1995019974A2 (fr) 1994-01-24 1995-01-24 Composes a base de calixarene presentant une activite antibacterienne, antifongique, anticancereuse et anti-vih

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AU (1) AU1545395A (fr)
WO (1) WO1995019974A2 (fr)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015566A1 (fr) * 1994-04-28 1997-05-01 Georghiou Paris E Oligomeres nouveaux, procede de preparation et procedes d'utilisation
NL1008988C2 (nl) * 1998-04-24 1999-10-26 Stichting Tech Wetenschapp Calixareenverbinding en een selectief molecuul voorzien van een dergelijke verbinding.
EP1005356A1 (fr) * 1998-06-08 2000-06-07 Advanced Medicine, Inc. Agents antibacteriens
EP1038871A1 (fr) * 1997-12-09 2000-09-27 Cosmo Research Institute Derives sulfones de sulfures phenoles cycliques, leur procede de preparation, agents de separation et de recuperation contenant des sulfures phenoles cycliques, procedes de separation et de recuperation utilisant ces agents, et compositions de medicaments contenant lesdits sulfures
WO2002044121A1 (fr) * 2000-12-01 2002-06-06 Aids Care Pharma Limited Composes antiviraux
EP1367044A1 (fr) * 2002-05-31 2003-12-03 Aids Care Pharma Limited Dérivés du calixarène à activité antivirale
DE10226099A1 (de) * 2002-06-12 2004-01-08 Jörg Martin Dipl.-Chem. Dormann Filtermaterial für Toxine, Bakterien, Viren und andere physiologische Schadstoffe
WO2004085442A2 (fr) * 2003-03-24 2004-10-07 Centre National De La Recherche Scientifique Nouveaux composes calix arenes, leur procede de preparation et leur utilisation, en particulier comme mimes de sites enzymatiques
WO2006042104A2 (fr) * 2004-10-04 2006-04-20 Regents Of The University Of Minnesota Mimetiques a conformation peptidique a base de calixarene, procedes d'utilisation, et procedes d'elaboration
US7338977B2 (en) * 2003-11-25 2008-03-04 Aids Care Pharma Limited Anti-viral compounds
WO2009025335A1 (fr) * 2007-08-23 2009-02-26 Jsr Corporation Composition et composé sensibles au rayonnement
FR2939666A1 (fr) * 2008-12-17 2010-06-18 Inst Radioprot Et De Surete Nu Formulations cosmetiques et pharmaceutiques de molecules de calix[6]arenes
AU2005208771B2 (en) * 2004-01-23 2011-11-24 The Trustees Of The University Of Pennsylvania Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof
US8236800B2 (en) 2003-03-17 2012-08-07 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers and oligomers and uses thereof
WO2012140364A1 (fr) * 2011-04-12 2012-10-18 Universite De Lorraine Utilisation de calixarenes dans le traitement des infections bacteriennes
WO2012140365A1 (fr) * 2011-04-12 2012-10-18 Universite De Lorraine Utilisation de calixarenes associes avec un antibiotique dans le traitement des infections bacteriennes
WO2013024777A1 (fr) * 2011-08-12 2013-02-21 三菱瓦斯化学株式会社 Composé cyclique ainsi que procédé de fabrication de celui-ci, composition, et procédé de formation de motif de réserve
KR20140093239A (ko) * 2011-11-18 2014-07-25 미쯔비시 가스 케미칼 컴파니, 인코포레이티드 환상 화합물, 그 제조 방법, 감방사선성 조성물 및 레지스트 패턴 형성 방법
KR20140104949A (ko) * 2011-11-18 2014-08-29 미쯔비시 가스 케미칼 컴파니, 인코포레이티드 환상 화합물, 그 제조방법, 감방사선성 조성물 및 레지스트 패턴 형성방법
US8889163B2 (en) 2001-03-08 2014-11-18 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers as anti-infective agents
WO2015196086A1 (fr) * 2014-06-20 2015-12-23 The University of Montana, Missoula, MT Nouveaux inhibiteurs du système xc(-)
CN107043364A (zh) * 2016-02-05 2017-08-15 徐州医学院 氧杂杯[4]芳烃衍生物及其应用
CN107325810A (zh) * 2017-06-29 2017-11-07 广东医科大学 一种穴状多羟基荧光化合物及其应用
WO2020074776A1 (fr) * 2018-10-08 2020-04-16 Aalto University Foundation Sr Composés macrocycliques et leurs utilisations
CN112771042A (zh) * 2018-09-28 2021-05-07 重庆复创医药研究有限公司 作为蛋白激酶抑制剂的萘啶酮和吡啶基嘧啶酮类化合物
CN115252869A (zh) * 2022-08-18 2022-11-01 南通大学 一种促进血管再生的纳米敷料及其制备方法

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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