WO1992010757A1 - Universalbindefilm - Google Patents

Universalbindefilm Download PDF

Info

Publication number
WO1992010757A1
WO1992010757A1 PCT/EP1991/002393 EP9102393W WO9210757A1 WO 1992010757 A1 WO1992010757 A1 WO 1992010757A1 EP 9102393 W EP9102393 W EP 9102393W WO 9210757 A1 WO9210757 A1 WO 9210757A1
Authority
WO
WIPO (PCT)
Prior art keywords
binding
matrix according
binding matrix
phase reactant
solid
Prior art date
Application number
PCT/EP1991/002393
Other languages
German (de)
English (en)
French (fr)
Inventor
Wolfgang Knoll
Franz-Josef Schmitt
Christian Klein
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Priority to DE59108149T priority Critical patent/DE59108149D1/de
Priority to EP92900474A priority patent/EP0515615B1/de
Priority to JP04502451A priority patent/JP3071823B2/ja
Publication of WO1992010757A1 publication Critical patent/WO1992010757A1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
PCT/EP1991/002393 1990-12-12 1991-12-12 Universalbindefilm WO1992010757A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE59108149T DE59108149D1 (de) 1990-12-12 1991-12-12 Universalbindefilm
EP92900474A EP0515615B1 (de) 1990-12-12 1991-12-12 Universalbindefilm
JP04502451A JP3071823B2 (ja) 1990-12-12 1991-12-12 多目的バインディングフィルム

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4039677A DE4039677A1 (de) 1990-12-12 1990-12-12 Universalbindefilm
DEP4039677.0 1990-12-12

Publications (1)

Publication Number Publication Date
WO1992010757A1 true WO1992010757A1 (de) 1992-06-25

Family

ID=6420156

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/002393 WO1992010757A1 (de) 1990-12-12 1991-12-12 Universalbindefilm

Country Status (6)

Country Link
EP (1) EP0515615B1 (ja)
JP (1) JP3071823B2 (ja)
AT (1) ATE142340T1 (ja)
DE (2) DE4039677A1 (ja)
ES (1) ES2093813T3 (ja)
WO (1) WO1992010757A1 (ja)

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0574000A1 (de) * 1992-06-11 1993-12-15 Roche Diagnostics GmbH Selbst assemblierende Monoschicht mit kurzkettigen Linkern
EP0664452A2 (de) * 1994-01-19 1995-07-26 Roche Diagnostics GmbH Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
EP0698787A1 (de) * 1994-08-24 1996-02-28 Roche Diagnostics GmbH Elektrochemischer Sensor
WO1996011404A1 (de) * 1994-10-06 1996-04-18 Boehringer Mannheim Gmbh Bindematrix und analysenelement zur simultananalyse verschiedener analyte
US5705348A (en) * 1993-12-10 1998-01-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5763191A (en) * 1990-12-12 1998-06-09 Boehringer Mannheim Gmbh Universal binding film
US5770369A (en) * 1993-12-10 1998-06-23 California Institute Of Technology Nucleic acid mediated electron transfer
US5851840A (en) * 1994-01-19 1998-12-22 Boehringer Mannheim Gmbh Biotinsilane compounds and a binding matrix containing these compounds
US5952172A (en) * 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
WO1999063345A1 (en) * 1998-05-29 1999-12-09 Dade Behring Inc. Method for detecting analytes
US6013170A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6071699A (en) * 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US6090933A (en) * 1996-11-05 2000-07-18 Clinical Micro Sensors, Inc. Methods of attaching conductive oligomers to electrodes
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
DE19924606A1 (de) * 1999-05-28 2000-11-30 Graffinity Pharm Design Gmbh Ligand-Anker-Konjugate
US6197515B1 (en) 1994-09-26 2001-03-06 Harvard University Molecular recognition at surfaces derivatized with self-assembled monolayers
US6232062B1 (en) 1997-03-07 2001-05-15 Clinical Micro Sensors, Inc. AC methods for the detection of nucleic acids
US6264825B1 (en) 1998-06-23 2001-07-24 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
WO2001094946A2 (en) * 2000-06-05 2001-12-13 Chiron Corporation Microarrays for performing proteomic analyses
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
US6472148B1 (en) 1994-09-26 2002-10-29 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6541617B1 (en) 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US6872522B1 (en) 1996-06-25 2005-03-29 Michael Mecklenburg Broad specificity affinity arrays: a qualitative approach to complex sample discrimination
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7090804B2 (en) 1998-01-27 2006-08-15 Clinical Mirco Sensors, Inc. Amplification of nucleic acids with electronic detection
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
US7153682B2 (en) 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7534331B2 (en) 1999-04-21 2009-05-19 Osmetech Technology Inc. Use of microfluidic systems in the electrochemical detection of target analytes
EP2232257A1 (en) * 2008-01-08 2010-09-29 Siemens Healthcare Diagnostics Inc. Stabilization of solid support assay reagents
EP2258724A1 (en) 2002-11-21 2010-12-08 Celltech R & D, Inc. Modulating immune responses using multimerized anti-CD83 antibodies
US7935481B1 (en) 1999-07-26 2011-05-03 Osmetech Technology Inc. Sequence determination of nucleic acids using electronic detection
US9874542B2 (en) 1998-09-17 2018-01-23 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
DE19715484A1 (de) * 1997-04-14 1998-10-15 Boehringer Mannheim Gmbh Verfahren zum Aufbringen von Reagenzspots
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
JP3261125B1 (ja) 2001-07-06 2002-02-25 有限会社大東土木 摩砕機
JPWO2003076933A1 (ja) 2002-03-11 2005-07-28 株式会社東京大学Ｔｌｏ 増大した密度のポリ（エチレンオキシド）のブラシ様構造表面
JP2022099742A (ja) * 2020-12-23 2022-07-05 昇陽國際半導體股▲ふん▼有限公司 バイオプローブのリンカー

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0112721A2 (en) * 1982-12-21 1984-07-04 Ares-Serono N.V. Assay technique
EP0254575A2 (en) * 1986-07-24 1988-01-27 ARS Holding 89 N.V. Polymer-coated optical structures
EP0263184A1 (en) * 1986-03-28 1988-04-13 Toray Industries, Inc. Immobilized physiologically active material
EP0295073A2 (en) * 1987-06-08 1988-12-14 Chromatochem, Inc. Chromatographic material
EP0339821A1 (en) * 1988-04-21 1989-11-02 United Kingdom Atomic Energy Authority Bonding to metal surfaces

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0112721A2 (en) * 1982-12-21 1984-07-04 Ares-Serono N.V. Assay technique
EP0263184A1 (en) * 1986-03-28 1988-04-13 Toray Industries, Inc. Immobilized physiologically active material
EP0254575A2 (en) * 1986-07-24 1988-01-27 ARS Holding 89 N.V. Polymer-coated optical structures
EP0295073A2 (en) * 1987-06-08 1988-12-14 Chromatochem, Inc. Chromatographic material
EP0339821A1 (en) * 1988-04-21 1989-11-02 United Kingdom Atomic Energy Authority Bonding to metal surfaces

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY. Bd. 28, 1989, EASTON, PA US Seiten 8221 - 8227; R. BLANKENBURG ET AL.: 'INTERACTION BETWEEN BIOTIN LIPIDS AND STREPTAVIDIN IN MONOLAYERS: FORMATION OF ORIENTED TWO-DIMENSIONAL PROTEIN DOMAINS INDUCED BY SURFACE RECOGNITION' in der Anmeldung erwähnt *

Cited By (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763191A (en) * 1990-12-12 1998-06-09 Boehringer Mannheim Gmbh Universal binding film
EP0574000A1 (de) * 1992-06-11 1993-12-15 Roche Diagnostics GmbH Selbst assemblierende Monoschicht mit kurzkettigen Linkern
US6528266B2 (en) 1993-12-10 2003-03-04 California Institute Of Technology Nucleic acid mediated electron transfer
US6177250B1 (en) 1993-12-10 2001-01-23 California Institute Of Technology Nucleic acid mediated electron transfer
US6087100A (en) * 1993-12-10 2000-07-11 California Institute Of Technology Nucleic acid mediated electron transfer
US5705348A (en) * 1993-12-10 1998-01-06 California Institute Of Technology Nucleic acid mediated electron transfer
US6258545B1 (en) 1993-12-10 2001-07-10 California Institute Of Technology Nucleic acid mediated electron transfer
US5770369A (en) * 1993-12-10 1998-06-23 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) * 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US6268150B1 (en) 1993-12-10 2001-07-31 California Institute Of Technology Nucleic acid mediated electron transfer
US6268149B1 (en) 1993-12-10 2001-07-31 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) * 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US6238870B1 (en) 1993-12-10 2001-05-29 California Institute Of Technology Nucleic acid mediated electron transfer
US6277576B1 (en) 1993-12-10 2001-08-21 California Institute Of Technology Nucleic acid mediated electron transfer
US6200761B1 (en) 1993-12-10 2001-03-13 California Institute Of Technology Nucleic acid mediated electron transfer
US6180352B1 (en) 1993-12-10 2001-01-30 California Insitute Of Technology Nucleic acid mediated electron transfer
US5851840A (en) * 1994-01-19 1998-12-22 Boehringer Mannheim Gmbh Biotinsilane compounds and a binding matrix containing these compounds
EP0664452A3 (de) * 1994-01-19 1996-10-23 Boehringer Mannheim Gmbh Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix.
EP0664452A2 (de) * 1994-01-19 1995-07-26 Roche Diagnostics GmbH Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
US5834224A (en) * 1994-08-24 1998-11-10 Boehringer Mannhein Gmbh Electrochemical sensor containing an enzyme linked to binding molecules bound to a noble metal surface
EP0698787A1 (de) * 1994-08-24 1996-02-28 Roche Diagnostics GmbH Elektrochemischer Sensor
US6322979B1 (en) 1994-09-26 2001-11-27 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6197515B1 (en) 1994-09-26 2001-03-06 Harvard University Molecular recognition at surfaces derivatized with self-assembled monolayers
US6472148B1 (en) 1994-09-26 2002-10-29 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
WO1996011404A1 (de) * 1994-10-06 1996-04-18 Boehringer Mannheim Gmbh Bindematrix und analysenelement zur simultananalyse verschiedener analyte
US6265155B1 (en) 1995-06-07 2001-07-24 California Institute Of Technology Metallic solid supports modified with nucleic acids
US6291188B1 (en) 1995-06-07 2001-09-18 California Institute Of Technology Metallic solid supports modified with nucleic acids
US7033760B2 (en) 1995-06-07 2006-04-25 California Institute Of Technology Metallic solid supports modified with nucleic acids
US6071699A (en) * 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
US6872522B1 (en) 1996-06-25 2005-03-29 Michael Mecklenburg Broad specificity affinity arrays: a qualitative approach to complex sample discrimination
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7384749B2 (en) 1996-11-05 2008-06-10 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7056669B2 (en) 1996-11-05 2006-06-06 Clinical Micro Sensors, Inc. AC methods for the detection of nucleic acids
US6221583B1 (en) 1996-11-05 2001-04-24 Clinical Micro Sensors, Inc. Methods of detecting nucleic acids using electrodes
US6977151B2 (en) 1996-11-05 2005-12-20 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US6479240B1 (en) 1996-11-05 2002-11-12 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US6090933A (en) * 1996-11-05 2000-07-18 Clinical Micro Sensors, Inc. Methods of attaching conductive oligomers to electrodes
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US6232062B1 (en) 1997-03-07 2001-05-15 Clinical Micro Sensors, Inc. AC methods for the detection of nucleic acids
US6013170A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US7514228B2 (en) 1997-06-12 2009-04-07 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US7267939B2 (en) 1997-06-12 2007-09-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6248229B1 (en) 1997-06-12 2001-06-19 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US7090804B2 (en) 1998-01-27 2006-08-15 Clinical Mirco Sensors, Inc. Amplification of nucleic acids with electronic detection
WO1999063345A1 (en) * 1998-05-29 1999-12-09 Dade Behring Inc. Method for detecting analytes
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6264825B1 (en) 1998-06-23 2001-07-24 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US7655129B2 (en) 1998-06-23 2010-02-02 Osmetech Technology Inc. Binding acceleration techniques for the detection of analytes
US9874542B2 (en) 1998-09-17 2018-01-23 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US8501921B2 (en) 1998-10-27 2013-08-06 Osmetech Technology, Inc. Detection of target analytes using particles and electrodes
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US7534331B2 (en) 1999-04-21 2009-05-19 Osmetech Technology Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US8486247B2 (en) 1999-04-21 2013-07-16 Osmetch Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US9151746B2 (en) 1999-04-21 2015-10-06 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US9557295B2 (en) 1999-04-21 2017-01-31 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
DE19924606A1 (de) * 1999-05-28 2000-11-30 Graffinity Pharm Design Gmbh Ligand-Anker-Konjugate
WO2000073796A3 (de) * 1999-05-28 2001-07-05 Graffinity Pharm Design Gmbh Ligand-anker-konjugate zur generierung einer biosensor-schicht
WO2000073796A2 (de) * 1999-05-28 2000-12-07 Graffinity Pharmaceutical Design Gmbh Ligand-anker-konjugate zur generierung einer biosensor-schicht
US7935481B1 (en) 1999-07-26 2011-05-03 Osmetech Technology Inc. Sequence determination of nucleic acids using electronic detection
US7153682B2 (en) 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
WO2001094946A3 (en) * 2000-06-05 2003-01-30 Chiron Corp Microarrays for performing proteomic analyses
WO2001094946A2 (en) * 2000-06-05 2001-12-13 Chiron Corporation Microarrays for performing proteomic analyses
EP2258724A1 (en) 2002-11-21 2010-12-08 Celltech R & D, Inc. Modulating immune responses using multimerized anti-CD83 antibodies
EP2232257A4 (en) * 2008-01-08 2011-05-25 Siemens Healthcare Diagnostics Stabilization of test reagents on a solid surface
EP2232257A1 (en) * 2008-01-08 2010-09-29 Siemens Healthcare Diagnostics Inc. Stabilization of solid support assay reagents

Also Published As

Publication number Publication date
EP0515615A1 (de) 1992-12-02
JP3071823B2 (ja) 2000-07-31
ES2093813T3 (es) 1997-01-01
ATE142340T1 (de) 1996-09-15
JPH05502515A (ja) 1993-04-28
DE59108149D1 (de) 1996-10-10
EP0515615B1 (de) 1996-09-04
DE4039677A1 (de) 1992-06-17

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