WO1992001675A3 - Composes bis-aryle bicycliques substitues ayant une activite antagoniste selective sur le leukotriene b4, leur preparation et utilisation dans des compositions pharmaceutiques - Google Patents
Composes bis-aryle bicycliques substitues ayant une activite antagoniste selective sur le leukotriene b4, leur preparation et utilisation dans des compositions pharmaceutiques Download PDFInfo
- Publication number
- WO1992001675A3 WO1992001675A3 PCT/EP1991/001341 EP9101341W WO9201675A3 WO 1992001675 A3 WO1992001675 A3 WO 1992001675A3 EP 9101341 W EP9101341 W EP 9101341W WO 9201675 A3 WO9201675 A3 WO 9201675A3
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- WIPO (PCT)
- Prior art keywords
- preparation
- pharmaceutical compositions
- antagonist activity
- substituted bicyclic
- compounds exhibiting
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/966,151 US5366982A (en) | 1990-07-24 | 1991-07-18 | Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene B4 antagonist activity, their preparation and use in pharmaceutical compositions |
JP91512181A JPH05508845A (ja) | 1990-07-24 | 1991-07-18 | 選択的ロイコトリエンb4拮抗活性を示す置換2環式ビス―アリール組成物、それらの調製および医薬組成物における使用 |
CS924031A CZ403192A3 (en) | 1990-07-24 | 1992-12-31 | Substituted bicyclic bis-aryl derivatives, process of their preparation and their use in pharmaceutical compositions |
NO93930201A NO930201L (no) | 1990-07-24 | 1993-01-21 | Substituerte bicykliske bis-arylforbindelser med selektivleukotrien-b4-antagonistaktivitet, deres fremstilling og bruk |
FI930256A FI930256A (fi) | 1990-07-24 | 1993-01-22 | Substituerade bicykliska bis-arylfoereningar med selektiv antagonistiskaktivitet mot leukotrien b4, framstaellning och anvaendning daerav i farmaceutiska kompositioner |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9009453A FR2665159B1 (fr) | 1990-07-24 | 1990-07-24 | Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
FR90/09453 | 1990-07-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1992001675A2 WO1992001675A2 (fr) | 1992-02-06 |
WO1992001675A3 true WO1992001675A3 (fr) | 1992-08-06 |
Family
ID=9399053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1991/001341 WO1992001675A2 (fr) | 1990-07-24 | 1991-07-18 | Composes bis-aryle bicycliques substitues ayant une activite antagoniste selective sur le leukotriene b4, leur preparation et utilisation dans des compositions pharmaceutiques |
Country Status (15)
Country | Link |
---|---|
US (2) | US5366982A (fr) |
EP (1) | EP0540604A1 (fr) |
JP (1) | JPH05508845A (fr) |
AU (1) | AU8194891A (fr) |
CA (1) | CA2087848A1 (fr) |
CZ (1) | CZ403192A3 (fr) |
FI (1) | FI930256A (fr) |
FR (1) | FR2665159B1 (fr) |
HU (1) | HUT68663A (fr) |
IE (1) | IE912589A1 (fr) |
IL (1) | IL98921A0 (fr) |
NO (1) | NO930201L (fr) |
PT (1) | PT98438A (fr) |
WO (1) | WO1992001675A2 (fr) |
ZA (1) | ZA915759B (fr) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE38506E1 (en) | 1991-10-04 | 2004-04-20 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
US5491172A (en) * | 1993-05-14 | 1996-02-13 | Warner-Lambert Company | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents |
IL109431A (en) * | 1993-05-14 | 2001-01-11 | Warner Lambert Co | Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds |
FR2705959B1 (fr) * | 1993-06-01 | 1995-08-11 | Oreal | Procédé de synthèse stéréospécifique de leucotriène B4 sous sa configuration 6Z, 8E, 10E et produits intermédiaires. |
TW416948B (en) * | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
JP2866202B2 (ja) * | 1994-04-13 | 1999-03-08 | エフ・ホフマン−ラ ロシュ アーゲー | 置換ピリジンロイコトリエンb▲下4▼拮抗物質 |
US5461049A (en) * | 1994-05-27 | 1995-10-24 | Warner-Lambert Company | Amide tetrazole ACAT inhibitors |
US5556990A (en) * | 1994-12-16 | 1996-09-17 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Polyarylcarbamoylaza- and -carbamoylalkanedioic acids |
US6103465A (en) * | 1995-02-14 | 2000-08-15 | The Perkin-Elmer Corporation | Methods and reagents for typing HLA class I genes |
US5571825A (en) * | 1995-03-31 | 1996-11-05 | Warner-Lambert Company | Method of selectively inhibiting prostaglandin G/H synthase-2 |
CA2224563A1 (fr) | 1995-06-12 | 1996-12-27 | G.D. Searle & Co. | Traitement d'inflammations par une combinaison d'un inhibiteur de la cyclooxygenase-2 et d'un antagoniste du recepteur de leukotriene b4 |
DE69733338T2 (de) * | 1996-02-13 | 2006-03-16 | G.D. Searle & Co., Chicago | Zubereitungen, enthaltend einen cyclooxygenase-2-inhibitor und einen leukotrien-b4-rezeptor-antagonisten |
US6416733B1 (en) | 1996-10-07 | 2002-07-09 | Bristol-Myers Squibb Pharma Company | Radiopharmaceuticals for imaging infection and inflammation |
AU736481C (en) * | 1996-10-07 | 2002-06-06 | Du Pont Pharmaceuticals Company | Radiopharmaceuticals for imaging infection and inflammation |
US20030124053A1 (en) * | 1996-10-07 | 2003-07-03 | Barrett John Andrew | Radiopharmaceuticals for imaging infection and inflammation |
US6410729B1 (en) | 1996-12-05 | 2002-06-25 | Amgen Inc. | Substituted pyrimidine compounds and methods of use |
AU6572298A (en) * | 1997-03-21 | 1998-10-20 | Eli Lilly And Company | Leukotriene antagonists useful for treating ischemia reperfusion injury |
US6174901B1 (en) | 1998-12-18 | 2001-01-16 | Amgen Inc. | Substituted pyridine and pyridazine compounds and methods of use |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
CA2360740A1 (fr) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Composes utiles en tant qu'inhibiteurs reversibles de la cathepsine s |
BR0014254A (pt) * | 1999-09-08 | 2002-08-27 | Sloan Kettering Inst Cancer | Nova classe de agentes de citodiferenciação e inibidores de desacetilase de histona, e métodos de uso dos mesmos |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
US6812237B2 (en) | 2000-05-15 | 2004-11-02 | Novartis Ag | N-substituted peptidyl nitriles as cysteine cathepsin inhibitors |
US20020198207A1 (en) * | 2000-05-18 | 2002-12-26 | Kath John Charles | Novel Hexanoic acid derivatives |
US6696466B1 (en) * | 2000-09-07 | 2004-02-24 | Leslie Joe Dunaway | Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines |
KR100883184B1 (ko) | 2000-12-11 | 2009-02-12 | 암젠 인코포레이션 | Cxcr3 길항제 |
WO2002076438A2 (fr) * | 2001-03-23 | 2002-10-03 | Chugai Seiyaku Kabushiki Kaisha | Ligands flt-1 et utilisations de ceux-ci |
TWI316055B (fr) * | 2001-04-26 | 2009-10-21 | Nippon Shinyaku Co Ltd | |
US6794379B2 (en) | 2001-06-06 | 2004-09-21 | Tularik Inc. | CXCR3 antagonists |
MY133579A (en) | 2001-07-13 | 2007-11-30 | Astrazeneca Uk Ltd | Preparation of aminopyrimidine compounds |
EP1474425B9 (fr) * | 2002-01-07 | 2008-07-02 | Eisai Co., Ltd. | Deazapurines et leurs utilisations |
CA2475879A1 (fr) * | 2002-02-15 | 2003-08-28 | Cytokinetics, Inc. | Synthesis de quinazolinones |
US6921752B2 (en) * | 2002-03-26 | 2005-07-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of LTB4 antagonists in veterinary medicine |
US7271266B2 (en) | 2002-03-28 | 2007-09-18 | Merck & Co., Inc. | Substituted 2,3-diphenyl pyridines |
WO2003097053A1 (fr) * | 2002-05-09 | 2003-11-27 | Cytokinetics, Inc. | Composes, compositions et procedes |
JP2006508030A (ja) * | 2002-05-09 | 2006-03-09 | サイトキネティクス・インコーポレーテッド | ピリミジノン化合物、組成物および方法 |
AU2003265242A1 (en) * | 2002-05-23 | 2003-12-22 | Cytokinetics, Inc. | Compounds, compositions, and methods |
AU2003236527A1 (en) * | 2002-06-14 | 2003-12-31 | Cytokinetics, Inc. | Compounds, compositions, and methods |
WO2004009036A2 (fr) * | 2002-07-23 | 2004-01-29 | Cytokinetics, Inc. | Composes, compositions et procedes |
AU2003262747A1 (en) * | 2002-08-21 | 2004-03-11 | Cytokinetics, Inc. | Compounds, compositions, and methods |
EP1546115A4 (fr) * | 2002-09-27 | 2010-08-04 | Merck Sharp & Dohme | Pyrimidines substituees |
EP1558083A4 (fr) * | 2002-09-30 | 2008-04-16 | Cytokinetics Inc | Composes, compositions, et procedes |
MXPA05006425A (es) | 2002-12-16 | 2005-08-19 | Astrazeneka Uk Ltd | Procedimiento para la preparacion de compuestos de pirimidina. |
JP2006523693A (ja) * | 2003-04-01 | 2006-10-19 | メモリアル スローン−ケタリング キャンサー センター | ヒドロキサム酸化合物およびその使用方法 |
MXPA05011103A (es) | 2003-04-16 | 2005-12-12 | Hoffmann La Roche | Compuestos de quinazolina. |
US20040254178A1 (en) * | 2003-04-16 | 2004-12-16 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
EP1660094A4 (fr) | 2003-08-26 | 2009-09-16 | Univ Colorado | Inhibiteurs de l'activite de la protease serine et leurs utilisations dans des methodes et preparations de traitement d'infections bacteriennes |
US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
JP2007510652A (ja) * | 2003-11-03 | 2007-04-26 | サイトキネティクス・インコーポレーテッド | ピリミジン−4−オン化合物、組成物、および方法 |
US20050148593A1 (en) * | 2003-11-07 | 2005-07-07 | Gustave Bergnes | Compounds, compositions, and methods |
EP1692112A4 (fr) * | 2003-12-08 | 2008-09-24 | Cytokinetics Inc | Composes, compositions, et methodes associees |
WO2005097137A2 (fr) * | 2004-03-31 | 2005-10-20 | The Scripps Research Institute | Inhibiteurs de proteines kinases ameliores a base de quinazoline |
RU2006144121A (ru) * | 2004-05-14 | 2008-06-20 | Айрм Ллк (Us) | Соединения и композиции в качестве модуляторов ppar рецепторов, активируемых пролифератором пероксисом |
US7541472B2 (en) * | 2004-05-24 | 2009-06-02 | Cropsolution, Inc. | 3-Aryl-3-hydroxy-2-methylenepropionic acid esters as fungicides |
GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
DE102005044156A1 (de) * | 2005-09-15 | 2007-03-29 | Riemser Arzneimittel Ag | Substituierte Acetophenonderivate |
RS54522B1 (en) * | 2005-12-22 | 2016-06-30 | Newron Pharmaceuticals S.P.A. | 2-Phenylethylamino Derivatives as Modulators of Calcium and (or Sodium) Channels |
DE102006021872B4 (de) * | 2006-05-11 | 2008-04-17 | Sanofi-Aventis | 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CA2662852A1 (fr) * | 2006-09-07 | 2008-03-13 | Allergan, Inc. | Composes heteroaromatiques presentant une activite biologique agoniste et/ou antagoniste sur le recepteur sphingosine-1-phosphate (s1p) |
US8093246B2 (en) * | 2006-12-14 | 2012-01-10 | Lexicon Pharmaceuticals, Inc. | O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer |
CA2680122A1 (fr) | 2007-03-05 | 2008-09-18 | Kyowa Hakko Kirin Co., Ltd. | Composition pharmaceutique |
US8093253B2 (en) | 2008-03-06 | 2012-01-10 | Hoffmann-La Roche Inc. | Leukotriene B4 inhibitors |
WO2010006939A1 (fr) | 2008-07-15 | 2010-01-21 | F. Hoffmann-La Roche Ag | Acides aminotétrahydroindazoloacétiques |
ES2386948T3 (es) | 2008-07-15 | 2012-09-07 | F. Hoffmann-La Roche Ag | Ácidos aminotetrahidroindazoloacéticos |
WO2010018109A2 (fr) | 2008-08-15 | 2010-02-18 | F. Hoffmann-La Roche Ag | Aminotétralines substituées |
EP2321268A2 (fr) | 2008-08-15 | 2011-05-18 | F. Hoffmann-La Roche AG | Bi-aryle aminotétralines |
US8124629B2 (en) | 2008-11-17 | 2012-02-28 | Hoffmann-La Roche Inc. | Naphthylacetic acids |
NZ591914A (en) | 2008-11-17 | 2013-04-26 | Hoffmann La Roche | Naphthylacetic acids |
US8188090B2 (en) | 2008-11-17 | 2012-05-29 | Hoffman-La Roche Inc. | Naphthylacetic acids |
EP2379076B1 (fr) | 2008-12-23 | 2014-11-12 | The Trustees of Columbia University in the City of New York | Inhibiteurs de la phosphodiestérase et utilisations de ces derniers |
US8586751B2 (en) | 2009-06-12 | 2013-11-19 | Bristol-Myers Squibb Company | Nicotinamide compounds useful as kinase modulators |
CN106035343B (zh) | 2010-07-20 | 2019-07-02 | 韦斯塔隆公司 | 三嗪类和嘧啶类杀虫剂 |
CA2816957A1 (fr) | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions et procedes de traitement de la myelofibrose |
GB201104153D0 (en) | 2011-03-11 | 2011-04-27 | Glaxo Group Ltd | Novel compounds |
CA2848631C (fr) | 2011-09-16 | 2019-10-01 | Hetero Research Foundation | Chlorhydrate de rilpivirine |
US8470884B2 (en) | 2011-11-09 | 2013-06-25 | Hoffmann-La Roche Inc. | Alkenyl naphthylacetic acids |
JP6322704B2 (ja) | 2013-06-27 | 2018-05-09 | エルジー・ケム・リミテッド | Gpr120アゴニストとしてのビアリール誘導体 |
MX2017002610A (es) | 2014-08-29 | 2017-10-11 | Tes Pharma S R L | INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA. |
DK3239143T3 (da) * | 2014-12-24 | 2023-04-11 | Lg Chemical Ltd | Biarylderivat som gpr120-agonist |
WO2017007755A1 (fr) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | N-aminophényl-amides hétérocycliques en tant qu'inhibiteurs de l'histone désacétylase |
US20180194769A1 (en) | 2015-07-06 | 2018-07-12 | Rodin Therapeutics, Inc. | Hetero-halo inhibitors of histone deacetylase |
WO2017048864A1 (fr) * | 2015-09-14 | 2017-03-23 | The Regents Of The University Of California | Préparation d'acides gras de furane à partir de 5-(chlorométhyl)furfural |
JP6756925B2 (ja) | 2017-01-11 | 2020-09-16 | ロダン・セラピューティクス,インコーポレーテッド | ヒストンデアセチラーゼの二環式阻害剤 |
DK3664802T3 (en) | 2017-08-07 | 2022-05-30 | Alkermes Inc | Bicyclic inhibitors of histone deacetylase |
WO2019079759A1 (fr) * | 2017-10-19 | 2019-04-25 | Laurence Rahme | Composés anti-persistance et anti-virulence à large spectre |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR5035M (fr) * | 1964-07-28 | 1967-05-02 | ||
EP0090353A1 (fr) * | 1982-03-27 | 1983-10-05 | Hoechst Aktiengesellschaft | Dérivés de la 2-pyridone, leur méthode de préparation et les médicaments les contenant |
EP0210084A1 (fr) * | 1985-05-30 | 1987-01-28 | Rhone-Poulenc Sante | Amides, procédés pour leur préparation et médicaments les contenant |
WO1987005510A1 (fr) * | 1986-03-13 | 1987-09-24 | Rorer International (Overseas) Inc. | Tetrazoles de thioether ou d'ether de quinolinyle utilises comme agents pour le traitement de troubles d'hypersensibilite |
EP0318083A2 (fr) * | 1987-11-25 | 1989-05-31 | Merck Frosst Canada Inc. | Acides pyridyl-dialkanoides et leur utilisation comme médicaments |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5758666A (en) * | 1980-09-24 | 1982-04-08 | Otsuka Pharmaceut Co Ltd | Alkanoic acid derivative |
CA1315279C (fr) * | 1987-01-12 | 1993-03-30 | Nancy Grace Bollinger | Agents antiinflammatoires |
CA1320490C (fr) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Agents antiinflammatoires |
US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
WO1989011279A1 (fr) * | 1988-05-16 | 1989-11-30 | Georgia State University Foundation, Inc. | Compose heteropolycyclique non fusionne ayant une interaction avec des acides nucleiques |
DE4445996C2 (de) * | 1994-12-22 | 2002-10-24 | Bosch Gmbh Robert | Verfahren zur Auslösung von Rückhaltemitteln |
-
1990
- 1990-07-24 FR FR9009453A patent/FR2665159B1/fr not_active Expired - Lifetime
-
1991
- 1991-07-18 EP EP91913522A patent/EP0540604A1/fr not_active Withdrawn
- 1991-07-18 US US07/966,151 patent/US5366982A/en not_active Expired - Fee Related
- 1991-07-18 JP JP91512181A patent/JPH05508845A/ja active Pending
- 1991-07-18 CA CA002087848A patent/CA2087848A1/fr not_active Abandoned
- 1991-07-18 HU HU9300190A patent/HUT68663A/hu unknown
- 1991-07-18 WO PCT/EP1991/001341 patent/WO1992001675A2/fr not_active Application Discontinuation
- 1991-07-18 AU AU81948/91A patent/AU8194891A/en not_active Abandoned
- 1991-07-22 IL IL98921A patent/IL98921A0/xx unknown
- 1991-07-23 ZA ZA915759A patent/ZA915759B/xx unknown
- 1991-07-23 IE IE258991A patent/IE912589A1/en unknown
- 1991-07-24 PT PT98438A patent/PT98438A/pt not_active Application Discontinuation
-
1992
- 1992-12-31 CZ CS924031A patent/CZ403192A3/cs unknown
-
1993
- 1993-01-21 NO NO93930201A patent/NO930201L/no unknown
- 1993-01-22 FI FI930256A patent/FI930256A/fi not_active Application Discontinuation
-
1994
- 1994-10-06 US US08/318,919 patent/US5492915A/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR5035M (fr) * | 1964-07-28 | 1967-05-02 | ||
EP0090353A1 (fr) * | 1982-03-27 | 1983-10-05 | Hoechst Aktiengesellschaft | Dérivés de la 2-pyridone, leur méthode de préparation et les médicaments les contenant |
EP0210084A1 (fr) * | 1985-05-30 | 1987-01-28 | Rhone-Poulenc Sante | Amides, procédés pour leur préparation et médicaments les contenant |
WO1987005510A1 (fr) * | 1986-03-13 | 1987-09-24 | Rorer International (Overseas) Inc. | Tetrazoles de thioether ou d'ether de quinolinyle utilises comme agents pour le traitement de troubles d'hypersensibilite |
EP0318083A2 (fr) * | 1987-11-25 | 1989-05-31 | Merck Frosst Canada Inc. | Acides pyridyl-dialkanoides et leur utilisation comme médicaments |
Non-Patent Citations (3)
Title |
---|
Chemical Abstracts, volume 97, 1982 (Columbus, Ohio, US) see page 617, abstract 110032x, & JP, A, 8258666 (OTSUKA PHARMACEUTICAL CO., LTD) 8 April 1982 (cited in the application) * |
J. Med. Chemistry, volume 33, no. 4, 1990, American Chemical Society, R.D. Youssefyeh et al.: "Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships", pages 772-777, see table I, compound 17 * |
J. Med. chemistry, volume 34, no. 2, 1991, American Chemical Society, C.R. Self et al.: ""Romazarit: a potential disease-modifying antirheumatic drug", pages 772-777, see table I, compound 17 * |
Also Published As
Publication number | Publication date |
---|---|
EP0540604A1 (fr) | 1993-05-12 |
US5492915A (en) | 1996-02-20 |
JPH05508845A (ja) | 1993-12-09 |
CZ403192A3 (en) | 1993-09-15 |
FI930256A0 (fi) | 1993-01-22 |
IL98921A0 (en) | 1992-07-15 |
NO930201D0 (no) | 1993-01-21 |
HU9300190D0 (en) | 1993-04-28 |
PT98438A (pt) | 1992-05-29 |
FR2665159B1 (fr) | 1992-11-13 |
NO930201L (no) | 1993-01-21 |
ZA915759B (en) | 1992-05-27 |
FI930256A (fi) | 1993-01-22 |
HUT68663A (en) | 1995-07-28 |
US5366982A (en) | 1994-11-22 |
CA2087848A1 (fr) | 1992-01-25 |
IE912589A1 (en) | 1992-01-29 |
FR2665159A1 (fr) | 1992-01-31 |
AU8194891A (en) | 1992-02-18 |
WO1992001675A2 (fr) | 1992-02-06 |
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