NO930201L - Substituerte bicykliske bis-arylforbindelser med selektivleukotrien-b4-antagonistaktivitet, deres fremstilling og bruk - Google Patents
Substituerte bicykliske bis-arylforbindelser med selektivleukotrien-b4-antagonistaktivitet, deres fremstilling og brukInfo
- Publication number
- NO930201L NO930201L NO93930201A NO930201A NO930201L NO 930201 L NO930201 L NO 930201L NO 93930201 A NO93930201 A NO 93930201A NO 930201 A NO930201 A NO 930201A NO 930201 L NO930201 L NO 930201L
- Authority
- NO
- Norway
- Prior art keywords
- selective
- preparation
- leukotrien
- antagonist activity
- substituted bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Forbindelser med selektive UBegenskaper med formel (I):. omfattende en aryl- eller heteroaryl mono- eller blcyklisk ring som har minst to substituenter bundet til seg; (1) en substituert eller usubstituert aryl- eller heteroaryl mono- eller blcyklisk ring og (2) en substltuent-kjede med terminale karboksylsyrefunksjonell gruppe eller derivater derav bundet dertil.Fremgangsmåter for fremstilling av forbindelsene beskrives.Forbindelsene egner seg for behandling av mangler som Involverer LTB-agonlstmedlert aktivitet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9009453A FR2665159B1 (fr) | 1990-07-24 | 1990-07-24 | Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
PCT/EP1991/001341 WO1992001675A2 (en) | 1990-07-24 | 1991-07-18 | Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene b4 antagonist activity, their preparation and use in pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
NO930201L true NO930201L (no) | 1993-01-21 |
NO930201D0 NO930201D0 (no) | 1993-01-21 |
Family
ID=9399053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO930201A NO930201D0 (no) | 1990-07-24 | 1993-01-21 | Substituerte bicykliske bis-arylforbindelser med selektivleukotrien-b4-antagonistaktivitet, deres fremstilling og bruk |
Country Status (15)
Country | Link |
---|---|
US (2) | US5366982A (no) |
EP (1) | EP0540604A1 (no) |
JP (1) | JPH05508845A (no) |
AU (1) | AU8194891A (no) |
CA (1) | CA2087848A1 (no) |
CZ (1) | CZ403192A3 (no) |
FI (1) | FI930256A (no) |
FR (1) | FR2665159B1 (no) |
HU (1) | HUT68663A (no) |
IE (1) | IE912589A1 (no) |
IL (1) | IL98921A0 (no) |
NO (1) | NO930201D0 (no) |
PT (1) | PT98438A (no) |
WO (1) | WO1992001675A2 (no) |
ZA (1) | ZA915759B (no) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE38506E1 (en) | 1991-10-04 | 2004-04-20 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
IL109431A (en) * | 1993-05-14 | 2001-01-11 | Warner Lambert Co | Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds |
US5491172A (en) * | 1993-05-14 | 1996-02-13 | Warner-Lambert Company | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents |
FR2705959B1 (fr) * | 1993-06-01 | 1995-08-11 | Oreal | Procédé de synthèse stéréospécifique de leucotriène B4 sous sa configuration 6Z, 8E, 10E et produits intermédiaires. |
TW448160B (en) * | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
CA2186252A1 (en) * | 1994-04-13 | 1995-10-26 | Noal Cohen | Substituted pyridine leukotriene b4 antagonists |
US5461049A (en) * | 1994-05-27 | 1995-10-24 | Warner-Lambert Company | Amide tetrazole ACAT inhibitors |
US5556990A (en) * | 1994-12-16 | 1996-09-17 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Polyarylcarbamoylaza- and -carbamoylalkanedioic acids |
US6103465A (en) * | 1995-02-14 | 2000-08-15 | The Perkin-Elmer Corporation | Methods and reagents for typing HLA class I genes |
US5571825A (en) * | 1995-03-31 | 1996-11-05 | Warner-Lambert Company | Method of selectively inhibiting prostaglandin G/H synthase-2 |
US6342510B1 (en) | 1995-06-12 | 2002-01-29 | G. D. Searle & Co. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist |
PT880362E (pt) | 1996-02-13 | 2005-10-31 | Searle & Co | Composicoes compreendendo um inibidor do cicloxigenase tipo 2 e um antagonista do receptor do leucotrieno b4 |
HUP0001167A3 (en) * | 1996-10-07 | 2002-03-28 | Du Pont Pharm Co | Radiopharmaceuticals for imaging infection and inflammation |
US20030124053A1 (en) * | 1996-10-07 | 2003-07-03 | Barrett John Andrew | Radiopharmaceuticals for imaging infection and inflammation |
US6416733B1 (en) | 1996-10-07 | 2002-07-09 | Bristol-Myers Squibb Pharma Company | Radiopharmaceuticals for imaging infection and inflammation |
US6410729B1 (en) | 1996-12-05 | 2002-06-25 | Amgen Inc. | Substituted pyrimidine compounds and methods of use |
AU6572298A (en) * | 1997-03-21 | 1998-10-20 | Eli Lilly And Company | Leukotriene antagonists useful for treating ischemia reperfusion injury |
US6174901B1 (en) | 1998-12-18 | 2001-01-16 | Amgen Inc. | Substituted pyridine and pyridazine compounds and methods of use |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
JP2002538151A (ja) | 1999-03-02 | 2002-11-12 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | カテプシンの可逆的インヒビターとして有用な化合物 |
WO2001018171A2 (en) * | 1999-09-08 | 2001-03-15 | Sloan-Kettering Institute For Cancer Research | Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
US6812237B2 (en) | 2000-05-15 | 2004-11-02 | Novartis Ag | N-substituted peptidyl nitriles as cysteine cathepsin inhibitors |
US20020198207A1 (en) * | 2000-05-18 | 2002-12-26 | Kath John Charles | Novel Hexanoic acid derivatives |
US6696466B1 (en) | 2000-09-07 | 2004-02-24 | Leslie Joe Dunaway | Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines |
KR100883184B1 (ko) | 2000-12-11 | 2009-02-12 | 암젠 인코포레이션 | Cxcr3 길항제 |
EP1370250A2 (en) * | 2001-03-23 | 2003-12-17 | Chugai Seiyaku Kabushiki Kaisha | Flt-1 ligands and their uses in the treatment of diseases regulatable by angiogenesis |
TWI316055B (no) | 2001-04-26 | 2009-10-21 | Nippon Shinyaku Co Ltd | |
US6794379B2 (en) | 2001-06-06 | 2004-09-21 | Tularik Inc. | CXCR3 antagonists |
HUP0401248A3 (en) | 2001-07-13 | 2004-11-29 | Astrazeneca Uk Ltd | Preparation of aminopyrimidine compounds and new intermediates |
SI1474425T1 (sl) | 2002-01-07 | 2006-10-31 | Eisai Co Ltd | Deazapurini in njihove uporabe |
CA2475879A1 (en) * | 2002-02-15 | 2003-08-28 | Cytokinetics, Inc. | Synthesis of quinazolinones |
US6921752B2 (en) * | 2002-03-26 | 2005-07-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of LTB4 antagonists in veterinary medicine |
EP1492784A4 (en) * | 2002-03-28 | 2006-03-29 | Merck & Co Inc | SUBSTITUTED 2,3-DIPHENYLPYRIDINES |
EP1553931A4 (en) * | 2002-05-09 | 2006-08-30 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
WO2003094839A2 (en) * | 2002-05-09 | 2003-11-20 | Cytokinetics, Inc. | Pyrimidinone compounds, compositions and methods |
EP1513820A4 (en) * | 2002-05-23 | 2006-09-13 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
US7041676B2 (en) * | 2002-06-14 | 2006-05-09 | Cytokinetics, Inc. | Compounds, compositions, and methods |
US7211580B2 (en) * | 2002-07-23 | 2007-05-01 | Cytokinetics, Incorporated | Compounds, compositions, and methods |
JP2005536553A (ja) * | 2002-08-21 | 2005-12-02 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
WO2004029204A2 (en) * | 2002-09-27 | 2004-04-08 | Merck & Co., Inc. | Substituted pyrimidines |
US7557115B2 (en) * | 2002-09-30 | 2009-07-07 | Cytokinetics, Inc. | Compounds, compositions, and methods |
KR101060215B1 (ko) | 2002-12-16 | 2011-08-29 | 아스트라제네카 유케이 리미티드 | 피리미딘 화합물의 제조 방법 |
US7199134B2 (en) * | 2003-04-01 | 2007-04-03 | Sloan-Kettering Institute For Cancer Research | Hydroxamic acid compounds and methods of use thereof |
MXPA05011103A (es) | 2003-04-16 | 2005-12-12 | Hoffmann La Roche | Compuestos de quinazolina. |
US20040254178A1 (en) * | 2003-04-16 | 2004-12-16 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
PL2520654T3 (pl) | 2003-08-26 | 2017-08-31 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych |
US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
EP1682534A2 (en) * | 2003-11-03 | 2006-07-26 | Cytokinetics, Inc. | Pyrimidin-4-one compounds, compositions, and methods |
US20050148593A1 (en) * | 2003-11-07 | 2005-07-07 | Gustave Bergnes | Compounds, compositions, and methods |
WO2005061460A1 (en) * | 2003-12-08 | 2005-07-07 | Cytokinetics, Inc. | Compounds, compositions, and methods |
WO2005097134A2 (en) * | 2004-03-31 | 2005-10-20 | The Scripps Research Institute | Quinazoline based protein kinase inhibitors |
US7745445B2 (en) * | 2004-05-14 | 2010-06-29 | Irm Llc | Compounds and compositions as PPAR modulators |
WO2005115148A1 (en) * | 2004-05-24 | 2005-12-08 | Cropsolution, Inc. | 3-aryl-3-hydroxy-2-methylenepropionic acid esters as fungicides |
GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
DE102005044156A1 (de) * | 2005-09-15 | 2007-03-29 | Riemser Arzneimittel Ag | Substituierte Acetophenonderivate |
US7855227B2 (en) | 2005-12-22 | 2010-12-21 | Newron Pharmaceuticals S.P.A. | 2-phenylethylamino derivatives as calcium and/or sodium channel modulators |
DE102006021872B4 (de) | 2006-05-11 | 2008-04-17 | Sanofi-Aventis | 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2066633A1 (en) * | 2006-09-07 | 2009-06-10 | Allergan, Inc. | Heteroaromatic compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity |
US8093246B2 (en) * | 2006-12-14 | 2012-01-10 | Lexicon Pharmaceuticals, Inc. | O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer |
CN101622015A (zh) | 2007-03-05 | 2010-01-06 | 协和发酵麒麟株式会社 | 药物组合物 |
US8093253B2 (en) | 2008-03-06 | 2012-01-10 | Hoffmann-La Roche Inc. | Leukotriene B4 inhibitors |
WO2010006939A1 (en) | 2008-07-15 | 2010-01-21 | F. Hoffmann-La Roche Ag | Aminotetrahydroindazoloacetic acids |
EP2307383B1 (en) | 2008-07-15 | 2012-05-16 | F. Hoffmann-La Roche AG | Aminotetrahydroindazoloacetic acids |
WO2010018109A2 (en) | 2008-08-15 | 2010-02-18 | F. Hoffmann-La Roche Ag | Substituted aminotetralines |
JP2012500189A (ja) | 2008-08-15 | 2012-01-05 | エフ.ホフマン−ラ ロシュ アーゲー | ビアリールアミノテトラリン |
KR20110071122A (ko) | 2008-11-17 | 2011-06-28 | 에프. 호프만-라 로슈 아게 | 나프틸아세트산 |
CN102216273A (zh) | 2008-11-17 | 2011-10-12 | 霍夫曼-拉罗奇有限公司 | 用作crth2拮抗剂或部分激动剂的萘乙酸 |
JP5463365B2 (ja) | 2008-11-17 | 2014-04-09 | エフ.ホフマン−ラ ロシュ アーゲー | ナフチル酢酸 |
EP2379076B1 (en) | 2008-12-23 | 2014-11-12 | The Trustees of Columbia University in the City of New York | Phosphodiesterase inhibitors and uses thereof |
US8586751B2 (en) | 2009-06-12 | 2013-11-19 | Bristol-Myers Squibb Company | Nicotinamide compounds useful as kinase modulators |
BR112013001217B1 (pt) | 2010-07-20 | 2019-11-19 | Vestaron Corp | composto, composição inseticida contendo o mesmo, e, método para controlar insetos |
CA2816957A1 (en) | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
GB201104153D0 (en) | 2011-03-11 | 2011-04-27 | Glaxo Group Ltd | Novel compounds |
CA2848631C (en) * | 2011-09-16 | 2019-10-01 | Hetero Research Foundation | Rilpivirine hydrochloride |
US8470884B2 (en) | 2011-11-09 | 2013-06-25 | Hoffmann-La Roche Inc. | Alkenyl naphthylacetic acids |
KR101662217B1 (ko) | 2013-06-27 | 2016-10-04 | 주식회사 엘지생명과학 | Gpr120 효능제로서의 바이아릴 유도체 |
ES2901114T3 (es) | 2014-08-29 | 2022-03-21 | Tes Pharma S R L | Inhibidores de ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa |
AU2015367977B9 (en) * | 2014-12-24 | 2020-02-06 | Lg Chem, Ltd | Biaryl derivative as GPR120 agonist |
US10421756B2 (en) | 2015-07-06 | 2019-09-24 | Rodin Therapeutics, Inc. | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase |
WO2017007756A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
US10399953B2 (en) | 2015-09-14 | 2019-09-03 | The Regents Of The University Of California | Preparation of furan fatty acids from 5-(chloromethyl)furfural |
EP3570834B1 (en) | 2017-01-11 | 2021-12-22 | Alkermes, Inc. | Bicyclic inhibitors of histone deacetylase |
US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
US11731946B2 (en) | 2017-10-19 | 2023-08-22 | The General Hospital Corporation | Broad spectrum antivirulence, anti-persistence compounds |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE667498A (no) * | 1964-07-28 | 1965-11-16 | ||
JPS5758666A (en) * | 1980-09-24 | 1982-04-08 | Otsuka Pharmaceut Co Ltd | Alkanoic acid derivative |
DE3211395A1 (de) * | 1982-03-27 | 1983-09-29 | Hoechst Ag, 6230 Frankfurt | Pyridon-2-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
EP0260305B1 (en) * | 1986-03-13 | 1992-12-16 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinolinyl ether tetrazole as agent for the treatment of hypersensitive ailments |
CA1315279C (en) * | 1987-01-12 | 1993-03-30 | Nancy Grace Bollinger | Anti-inflammatory agents |
CA1320490C (en) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Anti-inflammatory agents |
US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
US5004743A (en) * | 1987-11-25 | 1991-04-02 | Merck Frosst Canada, Inc. | Pyridyl styrene dialkanoic acids as anti-leukotriene agents |
AU3752589A (en) * | 1988-05-16 | 1989-12-12 | Georgia State University Research Foundation, Inc. | Nucleic acid interacting unfused heteropolycyclic compounds |
DE4445996C2 (de) * | 1994-12-22 | 2002-10-24 | Bosch Gmbh Robert | Verfahren zur Auslösung von Rückhaltemitteln |
-
1990
- 1990-07-24 FR FR9009453A patent/FR2665159B1/fr not_active Expired - Lifetime
-
1991
- 1991-07-18 WO PCT/EP1991/001341 patent/WO1992001675A2/en not_active Application Discontinuation
- 1991-07-18 JP JP91512181A patent/JPH05508845A/ja active Pending
- 1991-07-18 EP EP91913522A patent/EP0540604A1/en not_active Withdrawn
- 1991-07-18 CA CA002087848A patent/CA2087848A1/en not_active Abandoned
- 1991-07-18 US US07/966,151 patent/US5366982A/en not_active Expired - Fee Related
- 1991-07-18 HU HU9300190A patent/HUT68663A/hu unknown
- 1991-07-18 AU AU81948/91A patent/AU8194891A/en not_active Abandoned
- 1991-07-22 IL IL98921A patent/IL98921A0/xx unknown
- 1991-07-23 IE IE258991A patent/IE912589A1/en unknown
- 1991-07-23 ZA ZA915759A patent/ZA915759B/xx unknown
- 1991-07-24 PT PT98438A patent/PT98438A/pt not_active Application Discontinuation
-
1992
- 1992-12-31 CZ CS924031A patent/CZ403192A3/cs unknown
-
1993
- 1993-01-21 NO NO930201A patent/NO930201D0/no unknown
- 1993-01-22 FI FI930256A patent/FI930256A/fi not_active Application Discontinuation
-
1994
- 1994-10-06 US US08/318,919 patent/US5492915A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2665159A1 (fr) | 1992-01-31 |
IE912589A1 (en) | 1992-01-29 |
FI930256A0 (fi) | 1993-01-22 |
JPH05508845A (ja) | 1993-12-09 |
HUT68663A (en) | 1995-07-28 |
ZA915759B (en) | 1992-05-27 |
CA2087848A1 (en) | 1992-01-25 |
EP0540604A1 (en) | 1993-05-12 |
CZ403192A3 (en) | 1993-09-15 |
WO1992001675A3 (en) | 1992-08-06 |
FR2665159B1 (fr) | 1992-11-13 |
PT98438A (pt) | 1992-05-29 |
AU8194891A (en) | 1992-02-18 |
IL98921A0 (en) | 1992-07-15 |
US5492915A (en) | 1996-02-20 |
FI930256A (fi) | 1993-01-22 |
NO930201D0 (no) | 1993-01-21 |
WO1992001675A2 (en) | 1992-02-06 |
HU9300190D0 (en) | 1993-04-28 |
US5366982A (en) | 1994-11-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO930201L (no) | Substituerte bicykliske bis-arylforbindelser med selektivleukotrien-b4-antagonistaktivitet, deres fremstilling og bruk | |
ES2044836T3 (es) | Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene. | |
NO900306L (no) | Fremgangsmaate for fremstilling av nye pyrazolopyridin-forbindelser. | |
ATE44528T1 (de) | Arzneimittel mit antipsychotischer wirkung. | |
EP1069111A4 (en) | INDOLE DERIVATIVES EXER ANT ANTIVIRAL ACTIVITY | |
NO874454D0 (no) | Nye derivater av benzimidazoler med anti-ulcusaktivitet og fremgangsmaate for deres fremstilling. | |
ATE910T1 (de) | Derivate des 3.5-dihydroxypentansaeureesters mit antihyperlipaemischer aktivitaet, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen. | |
ATE74132T1 (de) | Imid-derivate, ihre herstellung und ihre verwendung. | |
CA2114727A1 (en) | Quinoline Derivatives as Immunostimulants | |
DE3665711D1 (de) | Novel guanidinomethylbenzoic acid derivatives | |
MX9300222A (es) | Nuevos derivados de arilcicloalquilo, su preparacion y su utilizacion. | |
NO941977L (no) | Indolderivater, fremgangsmåte for fremstilling av disse, og medisinsk anvendelse derav | |
SE8107273L (sv) | 2-oxoazetidinderivat, sett att framstella democh anvendning derav | |
IE43715L (en) | Rodenticidal diphenylamines | |
ATE39357T1 (de) | Derivate von griseolicsaeure und ihre verwendung. | |
DE3782347D1 (de) | Hetaryl-oxy-beta-carbolinderivate, ihre herstellung und verwendung als arzneimittel. | |
MY101142A (en) | 1, 4-dihydropyridine derivative, process for production thereof, and pharmaceutical use thereof. | |
IE40052B1 (en) | Indole derivatives | |
GB1531963A (en) | Pyrido(1,2alpha)pyrimidine derivatives | |
NO961236L (no) | Pyrrolodiazin-derivater som stabilisatorer for klorholdige polymerisater | |
GB1517960A (en) | Furanhydroxamic acid derivatives useful as fungicides | |
GB1158868A (en) | Novel 2,4-Disubstituted 7- and 8-Chloroquinolines, the preparation thereof and Compositions containing the same | |
DE3668888D1 (de) | Ein imidazolidintrion-derivat oder ein seiner pharmazeutisch akzeptierbaren salze enthaltende pharmazeutische zusammenstellung. | |
EA199900528A1 (ru) | Новые производные эритромицина, способ их получения и применения в качетве медикаментов | |
GB1498535A (en) | Heterocyclic compounds |