UY39290A - Un método para disminuir la inmunogenicidad de un fragmento de anticuerpo que comprende una cadena ligera variable y/o una cadena pesada variable - Google Patents

Un método para disminuir la inmunogenicidad de un fragmento de anticuerpo que comprende una cadena ligera variable y/o una cadena pesada variable

Info

Publication number
UY39290A
UY39290A UY0001039290A UY39290A UY39290A UY 39290 A UY39290 A UY 39290A UY 0001039290 A UY0001039290 A UY 0001039290A UY 39290 A UY39290 A UY 39290A UY 39290 A UY39290 A UY 39290A
Authority
UY
Uruguay
Prior art keywords
immunogenicity
reduce
antibody fragment
variable
heavy chain
Prior art date
Application number
UY0001039290A
Other languages
English (en)
Inventor
Tea Gunde
Jose Borras Leonardo
David Urech
Original Assignee
Esbatech Alcon Biomed Res Unit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esbatech Alcon Biomed Res Unit filed Critical Esbatech Alcon Biomed Res Unit
Publication of UY39290A publication Critical patent/UY39290A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se da a conocer un método para disminuir la inmunogenicidad de los dominios variables de un anticuerpo
UY0001039290A 2009-12-23 2010-12-22 Un método para disminuir la inmunogenicidad de un fragmento de anticuerpo que comprende una cadena ligera variable y/o una cadena pesada variable UY39290A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28944609P 2009-12-23 2009-12-23
UY0001033154A UY33154A (es) 2009-12-23 2010-12-22 Metodo para disminuir la unmunogenicidad

Publications (1)

Publication Number Publication Date
UY39290A true UY39290A (es) 2021-07-30

Family

ID=43733894

Family Applications (2)

Application Number Title Priority Date Filing Date
UY0001033154A UY33154A (es) 2009-12-23 2010-12-22 Metodo para disminuir la unmunogenicidad
UY0001039290A UY39290A (es) 2009-12-23 2010-12-22 Un método para disminuir la inmunogenicidad de un fragmento de anticuerpo que comprende una cadena ligera variable y/o una cadena pesada variable

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UY0001033154A UY33154A (es) 2009-12-23 2010-12-22 Metodo para disminuir la unmunogenicidad

Country Status (16)

Country Link
US (4) US8796425B2 (es)
EP (3) EP3498731A1 (es)
JP (6) JP5914353B2 (es)
KR (3) KR101758703B1 (es)
CN (2) CN102686608A (es)
AR (1) AR079700A1 (es)
AU (1) AU2010335950B2 (es)
BR (1) BR112012017051A2 (es)
CA (1) CA2777527C (es)
CL (1) CL2012001696A1 (es)
MX (2) MX352871B (es)
RU (1) RU2585534C2 (es)
TW (3) TW201925228A (es)
UY (2) UY33154A (es)
WO (1) WO2011075861A1 (es)
ZA (4) ZA201202299B (es)

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KR102007492B1 (ko) * 2008-06-25 2019-08-05 에스바테크 - 어 노바티스 컴파니 엘엘씨 보편적 항체 프레임워크를 사용한 래빗 항체의 인간화
JP6100463B2 (ja) * 2008-06-25 2017-03-22 エスバテック − ア ノバルティス カンパニー エルエルシー ＴＮＦαを阻害する安定かつ可溶性の抗体
KR102013220B1 (ko) * 2008-06-25 2019-08-23 에스바테크 - 어 노바티스 컴파니 엘엘씨 Ｖｅｇｆ를 억제하는 안정하고 가용성인 항체
KR101758703B1 (ko) * 2009-12-23 2017-07-18 에스바테크 - 어 노바티스 컴파니 엘엘씨 면역원성의 감소 방법
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
WO2012175741A2 (en) * 2011-06-23 2012-12-27 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
AR083495A1 (es) 2010-10-22 2013-02-27 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
PL3248986T3 (pl) * 2014-05-16 2022-05-16 Ablynx Nv Domeny zmienne immunoglobuliny
ES2900852T3 (es) 2014-05-16 2022-03-18 Ablynx Nv Métodos de detección y/o medición de anticuerpos anti-fármaco, en particular anticuerpos anti-fármaco que se presentan durante el tratamiento
JP7325928B2 (ja) 2014-05-16 2023-08-15 アブリンクス エン．ヴェー． 改善された免疫グロブリン可変ドメイン
KR20180072819A (ko) * 2015-10-30 2018-06-29 아블린쓰 엔.브이. Il-23에 대한 폴리펩티드
UA122079C2 (uk) 2015-12-04 2020-09-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Поліпептид, що специфічно зв'язується з lrp5 і lrp6
CN109689684B (zh) 2016-07-06 2022-09-23 细胞基因公司 具有低免疫原性的抗体及其用途
MA48760A (fr) 2017-05-31 2020-04-08 Boehringer Ingelheim Int Polypeptides ayant un effet antagoniste sur la signalisation wnt dans des cellules tumorales
EP3569618A1 (en) 2018-05-19 2019-11-20 Boehringer Ingelheim International GmbH Antagonizing cd73 antibody
TW202016151A (zh) 2018-06-09 2020-05-01 德商百靈佳殷格翰國際股份有限公司 針對癌症治療之多特異性結合蛋白
FR3088640A1 (fr) 2018-10-14 2020-05-22 Smart Diagnostix Pharma Nouveau polypeptide se liant specifiquement a la proteine p16
TW202128756A (zh) 2019-10-02 2021-08-01 德商百靈佳殷格翰國際股份有限公司 用於癌症治療之多重專一性結合蛋白
WO2022136693A1 (en) 2020-12-23 2022-06-30 Numab Therapeutics AG Antibody variable domains and antibodies having decreased immunogenicity
EP4183800A1 (en) 2021-11-19 2023-05-24 Medizinische Hochschule Hannover Novel sars-cov-2 neutralizing antibodies
WO2023110190A1 (en) 2021-12-13 2023-06-22 Heraeus Medical Gmbh Tests and methods for detecting bacterial infection
WO2023214047A1 (en) 2022-05-06 2023-11-09 Numab Therapeutics AG Antibody variable domains and antibodies having decreased immunogenicity
EP4273162A1 (en) * 2022-05-06 2023-11-08 Numab Therapeutics AG Antibody variable domains and antibodies having decreased immunogenicity
WO2024038095A1 (en) 2022-08-16 2024-02-22 Iome Bio NOVEL ANTI-RGMb ANTIBODIES
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BR0207283A (pt) * 2001-02-19 2004-08-17 Merck Patent Gmbh Anticorpos anti-egfr modificados com imunogenicidade reduzida
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GB0802931D0 (en) * 2008-02-18 2008-03-26 Queen Mary & Westfield College Synthetic scFv analogue to the 6313/G2 (anti angiotensin II type 1 receptor) monoclonal anitbody variable regions
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JP6100463B2 (ja) * 2008-06-25 2017-03-22 エスバテック − ア ノバルティス カンパニー エルエルシー ＴＮＦαを阻害する安定かつ可溶性の抗体
KR102007492B1 (ko) * 2008-06-25 2019-08-05 에스바테크 - 어 노바티스 컴파니 엘엘씨 보편적 항체 프레임워크를 사용한 래빗 항체의 인간화
SI3241843T1 (sl) 2008-06-25 2021-11-30 Novartis Ag Optimizacija topnosti imunoveziv
KR101758703B1 (ko) * 2009-12-23 2017-07-18 에스바테크 - 어 노바티스 컴파니 엘엘씨 면역원성의 감소 방법

Also Published As

Publication number Publication date
KR20170084357A (ko) 2017-07-19
ZA201202299B (en) 2014-06-25
JP2015131855A (ja) 2015-07-23
JP2013515460A (ja) 2013-05-09
ZA201706443B (en) 2020-12-23
EP3498731A1 (en) 2019-06-19
TW201125975A (en) 2011-08-01
WO2011075861A1 (en) 2011-06-30
JP2017121254A (ja) 2017-07-13
AR079700A1 (es) 2012-02-15
CA2777527A1 (en) 2011-06-30
US20110152505A1 (en) 2011-06-23
US10781268B2 (en) 2020-09-22
JP2021153603A (ja) 2021-10-07
CN102686608A (zh) 2012-09-19
KR101721187B1 (ko) 2017-03-29
TWI633184B (zh) 2018-08-21
RU2585534C2 (ru) 2016-05-27
JP2016094487A (ja) 2016-05-26
ZA202006532B (en) 2022-04-28
AU2010335950A1 (en) 2012-07-19
US20150080555A1 (en) 2015-03-19
KR101758703B1 (ko) 2017-07-18
US8796425B2 (en) 2014-08-05
TW201925228A (zh) 2019-07-01
KR20120102061A (ko) 2012-09-17
CL2012001696A1 (es) 2013-03-08
KR20170036137A (ko) 2017-03-31
CN109293768A (zh) 2019-02-01
US20180016350A1 (en) 2018-01-18
UY33154A (es) 2011-06-30
US20210214461A1 (en) 2021-07-15
EP4219545A1 (en) 2023-08-02
JP5914353B2 (ja) 2016-05-11
US9803027B2 (en) 2017-10-31
MX352871B (es) 2017-12-13
RU2012130945A (ru) 2014-01-27
JP2019141071A (ja) 2019-08-29
MX2012005345A (es) 2012-06-08
ZA201402145B (en) 2018-05-30
BR112012017051A2 (pt) 2017-12-05
TW201619383A (zh) 2016-06-01
CA2777527C (en) 2020-06-23
JP6815083B2 (ja) 2021-01-20
EP2516461A1 (en) 2012-10-31
AU2010335950B2 (en) 2014-08-21
TWI662128B (zh) 2019-06-11

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Effective date: 20221107