UY38262A - Inhibidores de moléculas pequeñas de la familia de quinasas jak - Google Patents

Inhibidores de moléculas pequeñas de la familia de quinasas jak

Info

Publication number
UY38262A
UY38262A UY0001038262A UY38262A UY38262A UY 38262 A UY38262 A UY 38262A UY 0001038262 A UY0001038262 A UY 0001038262A UY 38262 A UY38262 A UY 38262A UY 38262 A UY38262 A UY 38262A
Authority
UY
Uruguay
Prior art keywords
kinases
small molecule
molecule inhibitors
jak family
methods
Prior art date
Application number
UY0001038262A
Other languages
English (en)
Inventor
S Tichenor Mark
Philippe Fernandes
J Krawczuk Paul
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of UY38262A publication Critical patent/UY38262A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

Compuestos de 2-((1r,4r)-4-(imidazo[4,5-d]pirrolo[2,3-b]piridin-1(6H)-il)ciclohexil)acetonitrilo, composiciones farmacéuticas que los contienen, métodos para fabricarlos y métodos de uso de estos que incluyen los métodos para tratar estados de enfermedad, trastornos y afecciones mediadas por JAK.
UY0001038262A 2018-06-15 2019-06-14 Inhibidores de moléculas pequeñas de la familia de quinasas jak UY38262A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862685737P 2018-06-15 2018-06-15
US201962846290P 2019-05-10 2019-05-10

Publications (1)

Publication Number Publication Date
UY38262A true UY38262A (es) 2019-12-31

Family

ID=67766195

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001038262A UY38262A (es) 2018-06-15 2019-06-14 Inhibidores de moléculas pequeñas de la familia de quinasas jak

Country Status (23)

Country Link
US (3) US20200017498A1 (es)
EP (1) EP3807277A1 (es)
JP (1) JP2021528391A (es)
KR (1) KR20210021342A (es)
CN (1) CN112313233A (es)
AU (1) AU2019286641A1 (es)
BR (1) BR112020024744A2 (es)
CA (1) CA3101438A1 (es)
CL (1) CL2020003227A1 (es)
CO (1) CO2020015396A2 (es)
CR (1) CR20200603A (es)
EC (1) ECSP20080817A (es)
IL (1) IL279314A (es)
JO (1) JOP20200311A1 (es)
MA (1) MA52900A (es)
MX (1) MX2020013688A (es)
NI (1) NI202000100A (es)
PE (1) PE20212113A1 (es)
PH (1) PH12020551984A1 (es)
SG (1) SG11202011691PA (es)
TW (1) TW202016110A (es)
UY (1) UY38262A (es)
WO (1) WO2019239387A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
RS63500B1 (sr) 2016-12-16 2022-09-30 Janssen Pharmaceutica Nv Jedinjenja imidazo[4,5-d]pirolo[2,3-b]piridina kao inhibitori janus kinaza
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
CA3213134A1 (en) * 2021-03-11 2022-09-15 Janssen Pharmaceutica Nv Lorpucitinib for use in the treatment of jak mediated disorders
CN113292561A (zh) * 2021-05-22 2021-08-24 中国药科大学 一种二吡咯并吡啶结构的化合物、制备方法和医药用途

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080747A (en) 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
NZ515168A (en) 1999-04-23 2004-02-27 Smithkline Beecham Plc Polymorph of 5-[4-[2- (n-methyl-n-( 2-pyridyl)amino) ethoxy]benzyl] thiazolidine-2,4-dione, maleic acid salt
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
DE60319980T2 (de) 2002-05-31 2009-04-16 Schering Corporation Xanthin-phosphodiesterase-v-hemmer polymorphe
GB0319935D0 (en) 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
US7737279B2 (en) 2005-05-10 2010-06-15 Bristol-Myers Squibb Company 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same
BRPI0613574A2 (pt) 2005-07-01 2016-11-16 Wyeth Corp forma cristalina isolada de um composto, método para preparar um composto, e, composição farmacêutica
CN102127078A (zh) 2005-07-14 2011-07-20 安斯泰来制药株式会社 Janus激酶3的杂环类抑制剂
KR20080026654A (ko) 2005-07-14 2008-03-25 아스텔라스세이야쿠 가부시키가이샤 헤테로시클릭 야누스 키나제 3 억제제
DK2299821T3 (en) 2008-06-10 2016-02-15 Abbvie Inc Tricyclic compounds
EA022488B1 (ru) 2009-09-03 2016-01-29 Бристол-Майерс Сквибб Кампани Ингибиторы jak2 и их применение для лечения миелопролиферативных заболеваний и злокачественной опухоли
SG181147A1 (en) 2009-12-01 2012-07-30 Abbott Lab Novel tricyclic compounds
CN108774237A (zh) 2009-12-01 2018-11-09 Abbvie 公司 新的三环化合物
BR112012017269A2 (pt) 2010-01-12 2016-05-03 Hoffmann La Roche compostos heterocíclicos tricíclicos, composições e métodos de uso dos mesmos
US8841078B2 (en) 2010-02-10 2014-09-23 Genon Biotechnologies Oy Dual activity kinase domains and uses thereof
WO2013007765A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases
GB201212081D0 (en) 2012-07-06 2012-08-22 Kalvista Pharmaceuticals Ltd New polymorph
ES2755130T3 (es) 2013-02-08 2020-04-21 Nissan Chemical Corp Compuesto de pirrolopiridina tricíclico, e inhibidor de JAK
EP2924026A1 (en) 2014-03-28 2015-09-30 Novartis Tiergesundheit AG Aminosulfonylmethylcyclohexanes as JAK inhibitors
US9890165B2 (en) 2014-05-14 2018-02-13 Nissan Chemical Industries, Ltd. Tricyclic compound and JAK inhibitor
SI3303348T1 (sl) 2015-05-28 2019-12-31 Theravance Biopharma R&D Ip, Llc Naftiridinske spojine kot inhibitorji JAK kinaze
WO2017079639A1 (en) 2015-11-04 2017-05-11 Mayo Foundation For Medical Education And Research Methods and materials for treating autoimmune conditions
JOP20190053A1 (ar) 2016-09-23 2019-03-21 Novartis Ag مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط
MX2019004685A (es) 2016-10-24 2019-08-21 Astrazeneca Ab Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3f] isoquinolina utiles en el tratamiento del cancer.
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
PE20190977A1 (es) 2016-12-16 2019-07-09 Lilly Co Eli Compuestos de 7-feniletilamino-4h-pirimido [4,5-d][1,3]-oxazin-2-ona como inhibidores de idh1 e ihd2 mutantes
ES2934789T3 (es) 2016-12-16 2023-02-27 Pfizer Agonistas del receptor glp-1 y usos del mismo
MX2019006047A (es) 2016-12-16 2019-10-02 Nestle Sa Oligosacaridos para generacion de sabor.
RS63500B1 (sr) 2016-12-16 2022-09-30 Janssen Pharmaceutica Nv Jedinjenja imidazo[4,5-d]pirolo[2,3-b]piridina kao inhibitori janus kinaza
RU2019121534A (ru) 2016-12-16 2021-01-18 Басф Се Пестицидные соединения
PT3568396T (pt) 2017-01-11 2021-02-09 Leo Pharma As Novos derivados de amino-imidazopiridina como inibidores da cinase janus e sua utilização farmacêutica
JOP20190183B1 (ar) 2017-01-30 2022-09-15 Astrazeneca Ab معدِلات مستقبلات الاستروجين
CA3059939A1 (en) 2017-04-21 2018-10-25 Kyn Therapeutics Indole ahr inhibitors and uses thereof
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
WO2020216936A1 (en) 2019-04-24 2020-10-29 Janssen Pharmaceutica Nv Non-clinical liquid formulations of pan-jak inhibitor

Also Published As

Publication number Publication date
WO2019239387A1 (en) 2019-12-19
CN112313233A (zh) 2021-02-02
JOP20200311A1 (ar) 2020-11-30
MX2020013688A (es) 2021-02-26
KR20210021342A (ko) 2021-02-25
CA3101438A1 (en) 2019-12-19
TW202016110A (zh) 2020-05-01
AU2019286641A1 (en) 2020-12-10
US11066406B2 (en) 2021-07-20
CL2020003227A1 (es) 2021-05-14
EP3807277A1 (en) 2021-04-21
ECSP20080817A (es) 2021-01-29
BR112020024744A2 (pt) 2021-03-23
PH12020551984A1 (en) 2021-08-02
SG11202011691PA (en) 2020-12-30
US20210340144A1 (en) 2021-11-04
IL279314A (en) 2021-01-31
MA52900A (fr) 2021-04-21
US20200165250A1 (en) 2020-05-28
NI202000100A (es) 2021-06-30
US20200017498A1 (en) 2020-01-16
CO2020015396A2 (es) 2021-03-08
US11787807B2 (en) 2023-10-17
CR20200603A (es) 2021-01-20
PE20212113A1 (es) 2021-11-04
JP2021528391A (ja) 2021-10-21

Similar Documents

Publication Publication Date Title
ECSP19047936A (es) Imidazopirrolopiridina como inhibidores de la familia de quinasas jak
ECSP19042688A (es) Inhibidores de moléculas pequeñas de la familia de quinasas jak
UY38262A (es) Inhibidores de moléculas pequeñas de la familia de quinasas jak
EA202090659A1 (ru) СОСТАВЫ, СОДЕРЖАЩИЕ 6-(2-ГИДРОКСИ-2-МЕТИЛПРОПОКСИ)-4-(6-(6-((6-МЕТОКСИПИРИДИН-3-ИЛ)МЕТИЛ)-3,6-ДИАЗАБИЦИКЛО[3.1.1]ГЕПТАН-3-ИЛ)ПИРИДИН-3-ИЛ)ПИРАЗОЛО[1,5-a]ПИРИДИН-3-КАРБОНИТРИЛ
PE20190811A1 (es) Derivados de pirazolopirimidinas como inhibidor de quinasa
CR20160250A (es) Acrilamidas de pirrolo[2,3-d]piriminilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinilo
EA201790995A1 (ru) ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ И ИХ ПРИМЕНЕНИЕ ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ
EA201991109A1 (ru) ПРОИЗВОДНЫЕ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2
PA8675701A1 (es) Nuevos derivados del fluoreno, composiciones que los contienen y su utilización
MA49570A (fr) Composés bicycliques pyrazolo et triazolo utilisés en tant qu'inhibiteurs de kinase jak
EA201891067A1 (ru) [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИН-7-ИЛЬНОЕ СОЕДИНЕНИЕ
EA201991094A1 (ru) СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2
EA201990973A1 (ru) СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2
AR114969A1 (es) Inhibidores de moléculas pequeñas de la familia de quinasas jak
EA201991473A1 (ru) Имидазопирролопиридин в качестве ингибиторов киназ семейства jak
EA202190047A1 (ru) Низкомолекулярные ингибиторы киназ семейства jak
EA201991472A1 (ru) Низкомолекулярные ингибиторы киназ семейства jak
MA50430B1 (fr) Composés d'imidazo[4,5-d]pyrrolo[2,3-b]pyridine comme inhibiteurs de janus kinases
CR20190283A (es) Imidazopyrrolopyridine as inhibitors of the jak family of kinases