MX2020013688A - Inhibidores de moleculas peque?as de la familia de quinasas jak. - Google Patents

Inhibidores de moleculas peque?as de la familia de quinasas jak.

Info

Publication number
MX2020013688A
MX2020013688A MX2020013688A MX2020013688A MX2020013688A MX 2020013688 A MX2020013688 A MX 2020013688A MX 2020013688 A MX2020013688 A MX 2020013688A MX 2020013688 A MX2020013688 A MX 2020013688A MX 2020013688 A MX2020013688 A MX 2020013688A
Authority
MX
Mexico
Prior art keywords
kinases
small molecule
molecule inhibitors
jak family
methods
Prior art date
Application number
MX2020013688A
Other languages
English (en)
Inventor
Philippe Fernandes
Mark S Tichenor
Paul J Krawczuk
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2020013688A publication Critical patent/MX2020013688A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

Compuestos de 2-((1r,4r)-4-(imidazo[4,5-d]pirrolo[2,3-b]piridin-1( 6H)-il)ciclohexil)acetonitrilo, composiciones farmacéuticas que los contienen, métodos para elaborarlos y métodos para usarlos, que incluyen métodos para tratar estados de enfermedad, trastornos y condiciones mediados por JAK.
MX2020013688A 2018-06-15 2019-06-14 Inhibidores de moleculas peque?as de la familia de quinasas jak. MX2020013688A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862685737P 2018-06-15 2018-06-15
US201962846290P 2019-05-10 2019-05-10
PCT/IB2019/055005 WO2019239387A1 (en) 2018-06-15 2019-06-14 Small molecule inhibitors of the jak family of kinases

Publications (1)

Publication Number Publication Date
MX2020013688A true MX2020013688A (es) 2021-02-26

Family

ID=67766195

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020013688A MX2020013688A (es) 2018-06-15 2019-06-14 Inhibidores de moleculas peque?as de la familia de quinasas jak.

Country Status (23)

Country Link
US (3) US20200017498A1 (es)
EP (1) EP3807277A1 (es)
JP (1) JP2021528391A (es)
KR (1) KR20210021342A (es)
CN (1) CN112313233A (es)
AU (1) AU2019286641A1 (es)
BR (1) BR112020024744A2 (es)
CA (1) CA3101438A1 (es)
CL (1) CL2020003227A1 (es)
CO (1) CO2020015396A2 (es)
CR (1) CR20200603A (es)
EC (1) ECSP20080817A (es)
IL (1) IL279314A (es)
JO (1) JOP20200311A1 (es)
MA (1) MA52900A (es)
MX (1) MX2020013688A (es)
NI (1) NI202000100A (es)
PE (1) PE20212113A1 (es)
PH (1) PH12020551984A1 (es)
SG (1) SG11202011691PA (es)
TW (1) TW202016110A (es)
UY (1) UY38262A (es)
WO (1) WO2019239387A1 (es)

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AU2017377069B2 (en) 2016-12-16 2020-07-23 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
JP2024509587A (ja) * 2021-03-11 2024-03-04 ヤンセン ファーマシューティカ エヌ．ベー． Ｊａｋ媒介性障害の治療に使用するためのｌｏｒｐｕｃｉｔｉｎｉｂ
CN113292561A (zh) * 2021-05-22 2021-08-24 中国药科大学 一种二吡咯并吡啶结构的化合物、制备方法和医药用途

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Also Published As

Publication number Publication date
BR112020024744A2 (pt) 2021-03-23
PE20212113A1 (es) 2021-11-04
ECSP20080817A (es) 2021-01-29
US20200017498A1 (en) 2020-01-16
CL2020003227A1 (es) 2021-05-14
CN112313233A (zh) 2021-02-02
EP3807277A1 (en) 2021-04-21
JP2021528391A (ja) 2021-10-21
NI202000100A (es) 2021-06-30
CO2020015396A2 (es) 2021-03-08
PH12020551984A1 (en) 2021-08-02
JOP20200311A1 (ar) 2020-11-30
MA52900A (fr) 2021-04-21
SG11202011691PA (en) 2020-12-30
KR20210021342A (ko) 2021-02-25
US11066406B2 (en) 2021-07-20
TW202016110A (zh) 2020-05-01
AU2019286641A1 (en) 2020-12-10
CR20200603A (es) 2021-01-20
CA3101438A1 (en) 2019-12-19
US20210340144A1 (en) 2021-11-04
WO2019239387A1 (en) 2019-12-19
IL279314A (en) 2021-01-31
US20200165250A1 (en) 2020-05-28
UY38262A (es) 2019-12-31
US11787807B2 (en) 2023-10-17

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