UY32051A - Compuestos de azetidinas polisustituidos, su preparación y su aplicación en terapéutica - Google Patents

Compuestos de azetidinas polisustituidos, su preparación y su aplicación en terapéutica

Info

Publication number
UY32051A
UY32051A UY0001032051A UY32051A UY32051A UY 32051 A UY32051 A UY 32051A UY 0001032051 A UY0001032051 A UY 0001032051A UY 32051 A UY32051 A UY 32051A UY 32051 A UY32051 A UY 32051A
Authority
UY
Uruguay
Prior art keywords
preparation
polyustituted
therapeutics
application
compounds
Prior art date
Application number
UY0001032051A
Other languages
English (en)
Inventor
Corinne Terrier
Bernardelli Patrick
Sabuco Jean-Francois
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of UY32051A publication Critical patent/UY32051A/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)

Abstract

Compuestos de azetidinas polisustituidos que responden a la fórmula (I) en el estado de base o de sal de adición a un ácido, donde los radicales, sustituyentes e índices son tales como se especifican en la Memoria descriptiva y en las Reivindicaciones. Se divulgan los procedimientos de preparación y su aplicación terapéutica en el tratamiento o la prevención de enfermedades que implican a los receptores de los cannabinoides CB1.
UY0001032051A 2008-08-14 2009-08-14 Compuestos de azetidinas polisustituidos, su preparación y su aplicación en terapéutica UY32051A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0804595A FR2934995B1 (fr) 2008-08-14 2008-08-14 Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
UY32051A true UY32051A (es) 2010-03-26

Family

ID=40352689

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032051A UY32051A (es) 2008-08-14 2009-08-14 Compuestos de azetidinas polisustituidos, su preparación y su aplicación en terapéutica

Country Status (16)

Country Link
US (1) US20110152236A1 (es)
EP (1) EP2313393A1 (es)
JP (1) JP2011530575A (es)
KR (1) KR20110044782A (es)
CN (1) CN102186839A (es)
AR (1) AR073043A1 (es)
AU (1) AU2009281057A1 (es)
BR (1) BRPI0917464A2 (es)
CA (1) CA2733397A1 (es)
FR (1) FR2934995B1 (es)
IL (1) IL211210A0 (es)
MX (1) MX2011001678A (es)
RU (1) RU2011109180A (es)
TW (1) TW201011019A (es)
UY (1) UY32051A (es)
WO (1) WO2010018328A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130102477A1 (en) 2010-06-23 2013-04-25 Ryan D. Morin Biomarkers for non-hodgkin lymphomas and uses thereof
DK2614369T3 (en) 2010-09-10 2016-05-02 Epizyme Inc METHOD FOR DETERMINING THE SUITABILITY OF HUMAN EZH2 INHIBITORS TREATED
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
ES2745016T3 (es) 2012-04-13 2020-02-27 Epizyme Inc Bromhidrato de N-((4,6-dimetil-2-oxo-L,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H-piran-4-il)amino)-4-metil-4'-(morfolinometil)-[L,1'-bifenil]-3-carboxamida para su uso en el tratamiento de un trastorno proliferativo celular del sistema hematológico
EP2906538A4 (en) 2012-10-15 2016-05-11 Epizyme Inc SUBSTITUTED BENZOL COMPOUNDS
JP6608812B2 (ja) 2013-10-16 2019-11-20 エピザイム，インコーポレイティド Ｅｚｈ２阻害のための塩酸塩形
JP2023509452A (ja) 2020-01-03 2023-03-08 バーグ エルエルシー がんを処置するためのｕｂｅ２ｋモジュレータとしての多環式アミド

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2805817B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation
FR2928149B1 (fr) * 2008-02-29 2011-01-14 Sanofi Aventis Composes derives d'azetidines, leur preparation et leur application en therapeutique
FR2934996B1 (fr) * 2008-08-14 2010-08-27 Sanofi Aventis Composes polysubstitues d'azetidines, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
AU2009281057A1 (en) 2010-02-18
CA2733397A1 (fr) 2010-02-18
WO2010018328A1 (fr) 2010-02-18
EP2313393A1 (fr) 2011-04-27
US20110152236A1 (en) 2011-06-23
IL211210A0 (en) 2011-04-28
BRPI0917464A2 (pt) 2015-12-01
KR20110044782A (ko) 2011-04-29
FR2934995B1 (fr) 2010-08-27
AR073043A1 (es) 2010-10-06
CN102186839A (zh) 2011-09-14
MX2011001678A (es) 2011-04-05
JP2011530575A (ja) 2011-12-22
FR2934995A1 (fr) 2010-02-19
TW201011019A (en) 2010-03-16
RU2011109180A (ru) 2012-09-20

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