UY24389A1 - Composición farmacéutica para el tratamiento de carcinoma de epitelio plano - Google Patents

Composición farmacéutica para el tratamiento de carcinoma de epitelio plano

Info

Publication number
UY24389A1
UY24389A1 UY24389A UY24389A UY24389A1 UY 24389 A1 UY24389 A1 UY 24389A1 UY 24389 A UY24389 A UY 24389A UY 24389 A UY24389 A UY 24389A UY 24389 A1 UY24389 A1 UY 24389A1
Authority
UY
Uruguay
Prior art keywords
pharmaceutical composition
treatment
flat epithelium
antibody
epithelium carcinoma
Prior art date
Application number
UY24389A
Other languages
English (en)
Spanish (es)
Inventor
Marlies Sproll
Erik Patzelt
Elingborg Ostermann
Guenther Adolf
Karl-Heinz Heider
Original Assignee
Karlsruhe Forschzent
Boheringer Ingelheim Internat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19545472A external-priority patent/DE19545472A1/de
Application filed by Karlsruhe Forschzent, Boheringer Ingelheim Internat filed Critical Karlsruhe Forschzent
Publication of UY24389A1 publication Critical patent/UY24389A1/es

Links

Classifications

    • G01N33/575—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
UY24389A 1995-12-06 1996-12-03 Composición farmacéutica para el tratamiento de carcinoma de epitelio plano UY24389A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19545472A DE19545472A1 (de) 1995-12-06 1995-12-06 Verfahren zur Diagnose und Therapie von Plattenepithelkarzinomen
DE19615074 1996-04-17

Publications (1)

Publication Number Publication Date
UY24389A1 true UY24389A1 (es) 2001-10-25

Family

ID=26020988

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24389A UY24389A1 (es) 1995-12-06 1996-12-03 Composición farmacéutica para el tratamiento de carcinoma de epitelio plano

Country Status (25)

Country Link
EP (1) EP0865609B1 (enExample)
JP (1) JP2000502067A (enExample)
KR (1) KR100473824B1 (enExample)
CN (1) CN1151377C (enExample)
AR (1) AR004360A1 (enExample)
AT (1) ATE235056T1 (enExample)
AU (1) AU726704B2 (enExample)
BG (1) BG62985B1 (enExample)
BR (1) BR9611901A (enExample)
CA (1) CA2239709A1 (enExample)
CO (1) CO4520233A1 (enExample)
CZ (1) CZ174198A3 (enExample)
DE (1) DE59610248D1 (enExample)
DK (1) DK0865609T3 (enExample)
EE (1) EE03783B1 (enExample)
ES (1) ES2190484T3 (enExample)
MX (1) MX9804459A (enExample)
NO (1) NO319903B1 (enExample)
NZ (1) NZ324314A (enExample)
PL (1) PL184521B1 (enExample)
PT (1) PT865609E (enExample)
SK (1) SK284378B6 (enExample)
TR (1) TR199801027T2 (enExample)
UY (1) UY24389A1 (enExample)
WO (1) WO1997021104A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947496B2 (en) * 1999-10-08 2011-05-24 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7189397B2 (en) * 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20030103985A1 (en) 2001-05-18 2003-06-05 Boehringer Ingelheim International Gmbh Cytotoxic CD44 antibody immunoconjugates
EP1258255A1 (en) * 2001-05-18 2002-11-20 Boehringer Ingelheim International GmbH Conjugates of an antibody to CD44 and a maytansinoid
CN1541226A (zh) * 2001-05-18 2004-10-27 ���ָ��Ӣ��ķ�������Ϲ�˾ CD44v6特异性的抗体
US6972324B2 (en) 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
EP1391213A1 (en) * 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
EP1417974A1 (en) * 2002-11-08 2004-05-12 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
JP5763105B2 (ja) * 2010-02-04 2015-08-12 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 頭頸部扁平上皮癌の治療に使用されるｃｄ４４に対するモノクローナル抗体
US9218450B2 (en) 2012-11-29 2015-12-22 Roche Molecular Systems, Inc. Accurate and fast mapping of reads to genome
EP3755717A4 (en) * 2018-02-22 2022-01-26 Multitude Inc. THERAPEUTIC ANTIBODY AND USES THEREOF
IL317000A (en) 2022-05-25 2025-01-01 Akiram Therapeutics Ab Antibodies against CD44V6 and their use in the treatment of cancers that overexpress CD44V6

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69406664T2 (de) * 1993-06-18 1998-06-04 Biotie Therapies Oy Zusammensetzungen und diagnostische verfahren unter verwendung von monoklonalen antikoerpern gegen cd44v6
WO1995000851A1 (de) * 1993-06-22 1995-01-05 Boehringer Ingelheim International Gmbh Verfahren zur diagnose und analyse von tumoren
DE4326573A1 (de) * 1993-08-07 1995-02-23 Boehringer Ingelheim Int Durch Exon v5 des CD44-Gens kodierte Polypeptide als Targets für Immuntherapie und Immunszintigraphie von Tumoren
UA58482C2 (uk) * 1994-06-08 2003-08-15 Бьорінгер Інгельхайм Інтернаціональ Гмбх Моноклональне антитіло vff-18 проти сd44v6 і його фрагменти

Also Published As

Publication number Publication date
NO319903B1 (no) 2005-09-26
KR19990071952A (ko) 1999-09-27
MX9804459A (es) 1998-09-30
JP2000502067A (ja) 2000-02-22
EE03783B1 (et) 2002-06-17
CZ174198A3 (cs) 1999-02-17
EE9800164A (et) 1998-12-15
DE59610248D1 (de) 2003-04-24
AR004360A1 (es) 1998-11-04
BR9611901A (pt) 1999-03-02
CA2239709A1 (en) 1997-06-12
KR100473824B1 (ko) 2005-09-30
SK284378B6 (sk) 2005-02-04
NO982588D0 (no) 1998-06-05
PL327066A1 (en) 1998-11-23
ATE235056T1 (de) 2003-04-15
CN1151377C (zh) 2004-05-26
NZ324314A (en) 2000-02-28
HK1011560A1 (en) 1999-07-16
EP0865609A1 (de) 1998-09-23
DK0865609T3 (da) 2003-06-23
AU1177397A (en) 1997-06-27
BG62985B1 (bg) 2000-12-29
AU726704B2 (en) 2000-11-16
PT865609E (pt) 2003-08-29
NO982588L (no) 1998-08-05
ES2190484T3 (es) 2003-08-01
CN1207811A (zh) 1999-02-10
SK73698A3 (en) 1999-01-11
BG102513A (en) 1999-02-26
TR199801027T2 (xx) 1998-10-21
WO1997021104A1 (de) 1997-06-12
CO4520233A1 (es) 1997-10-15
PL184521B1 (pl) 2002-11-29
EP0865609B1 (de) 2003-03-19

Similar Documents

Publication Publication Date Title
CA2541438C (en) The modulation of hyaluronan synthesis and degradation in the treatment of disease
UY24389A1 (es) Composición farmacéutica para el tratamiento de carcinoma de epitelio plano
MX2023004349A (es) Anticuerpos monoclonales anti-ccr8 y sus usos.
BR0110927A (pt) Anticorpo, ácido nucléico, vetor, célula, método de fabricar um anticorpo, composição farmacêutica, uso de um anticorpo ou de um ácido nucleico, e, método para o tratamento ou profilaxia do câncer
JP2019110906A5 (enExample)
BRPI0409879A (pt) composições e métodos para imunoterapia especìfica wt1
PE20230415A1 (es) ANTICUERPOS MONOCLONALES HUMANOS DIRIGIDOS CONTRA EL CORONAVIRUS 2 DEL SINDROME RESPIRATORIO AGUDO GRAVE (SARS-CoV-2)
JP2016116536A5 (enExample)
PE20091713A1 (es) Inhibicion del receptor para la proteina estimulante del macrofago (ron), composiciones y metodos
CY1109421T1 (el) ΔΟΣΕΙΣ ΓΙΑ ΑΓΩΓΗ ΜΕ ΑΝΤΙΣΩΜΑΤΑ ΑΝΤΙ-ErbB2
WO2020146902A3 (en) Anti-variable muc1* antibodies and uses thereof
ATE335072T1 (de) Methoden für inhibition der cd14-abhängigen zellaktivierung
MXPA01003344A (es) Composiciones y metodos para inmunoterapia especifica de wt1.
RU2010119521A (ru) Антитела, связывающие il-4 и/или il-13, и их применение
RU2009117299A (ru) Применение моноклональных антител, специфичных к о-ацетилированной форме ганглиозида gd2, для лечения некоторых форм рака
AR066164A1 (es) Proteinas humanas de union a antigenos del factor estimulante de colonias de megacariocitos-macrofagos(gm-csf)
PE20110822A1 (es) Combinaciones antitumorales que contienen anticuerpos que reconocen especificamente cd38 y ciclofosfamida
UA86768C2 (ru) ХИМЕРНОЕ МОНОКЛОНАЛЬНОЕ АНТИТЕЛО, ПОЛУЧЕННОЕ ИЗ МЫШИНОГО АНТИИДИОТИПИЧНОГО МОНОКЛОНАЛЬНОГО АНТИТЕЛА 1Е10, КОТОРОЕ РАСПОЗНАЕТ МЫШИНОЕ MAbР3
CO4410258A1 (es) ANTICUERPOS MONOCLONALES CONTRA CD44v6
Shohet et al. Identification of a major binding site for complement C3 on the IgG1 heavy chain.
BR112022009570A2 (pt) Anticorpo anti-¿v¿6 isolado ou fragmento de ligação ao antígeno, conjugado anticorpo-fármaco, ácido nucleico, vetor, célula hospedeira, métodos para produção de um anticorpo anti-¿v¿6 ou fragmento de ligação ao antígeno, para produção de um conjugado anticorpo anti-¿v¿6-fármaco e para tratamento de câncer em um indivíduo, e, composição farmacêutica
NZ596981A (en) Compositions and methods for the treatment of tumor of hematopoietic origin
RU2017134043A (ru) Модифицированные антитела igg, которые связываются с трансформирующим фактором роста бета-1 с высокой аффинностью, авидностью и специфичностью
Koro et al. Carbamylation of immunoglobulin abrogates activation of the classical complement pathway
AR123537A1 (es) Anticuerpo contra hla-dq2.5 y su uso para el tratamiento de la enfermedad celíaca

Legal Events

Date Code Title Description
VENC Patent expired

Effective date: 20161203