US8046059B2 - Mobile diagnosis device - Google Patents

Mobile diagnosis device Download PDF

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Publication number
US8046059B2
US8046059B2 US11/886,794 US88679406A US8046059B2 US 8046059 B2 US8046059 B2 US 8046059B2 US 88679406 A US88679406 A US 88679406A US 8046059 B2 US8046059 B2 US 8046059B2
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unit
ecg
signal
volume pulse
pulse signal
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US11/886,794
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US20080200823A1 (en
Inventor
Ok Kyung Cho
Yoon Ok Kim
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Assigned to FLORE, INGO reassignment FLORE, INGO ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CHO, OK KYUNG, KIM, YOON OK
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0285—Measuring or recording phase velocity of blood waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/346—Analysis of electrocardiograms
    • A61B5/349—Detecting specific parameters of the electrocardiograph cycle
    • A61B5/352—Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
    • A61B5/7214—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Eye Examination Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
US11/886,794 2005-03-21 2006-03-16 Mobile diagnosis device Active 2026-04-27 US8046059B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102005013429A DE102005013429A1 (de) 2005-03-21 2005-03-21 Mobiles Diagnosegerät
DE102005013429.7 2005-03-21
DE102005013429 2005-03-21
PCT/EP2006/002410 WO2006099988A1 (de) 2005-03-21 2006-03-16 Mobiles diagnosegerät

Publications (2)

Publication Number Publication Date
US20080200823A1 US20080200823A1 (en) 2008-08-21
US8046059B2 true US8046059B2 (en) 2011-10-25

Family

ID=36607466

Family Applications (1)

Application Number Title Priority Date Filing Date
US11/886,794 Active 2026-04-27 US8046059B2 (en) 2005-03-21 2006-03-16 Mobile diagnosis device

Country Status (10)

Country Link
US (1) US8046059B2 (ru)
EP (1) EP1860999B1 (ru)
JP (2) JP2008532719A (ru)
KR (1) KR101286402B1 (ru)
CN (1) CN101170944B (ru)
AT (1) ATE452580T1 (ru)
CA (1) CA2602269C (ru)
DE (2) DE102005013429A1 (ru)
EA (1) EA013620B1 (ru)
WO (1) WO2006099988A1 (ru)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080275317A1 (en) * 2005-08-09 2008-11-06 Ok Kyung Cho Medical Measuring Device
US20100056880A1 (en) * 2006-11-23 2010-03-04 Ok Kyung Cho Medical measuring device
US20100234701A1 (en) * 2007-09-07 2010-09-16 Ok Kyung Cho Medical measurement device for bioelectrical impedance measurement
US20120310103A1 (en) * 2011-06-02 2012-12-06 Nokia Siemens Networks Oy Heart monitor with user input
US9101264B2 (en) 2006-06-15 2015-08-11 Peerbridge Health, Inc. Wireless electrode arrangement and method for patient monitoring via electrocardiography
US9675264B2 (en) 2013-03-15 2017-06-13 Peerbridge Health, Inc. System and method for monitoring and diagnosing patient condition based on wireless sensor monitoring data
US9833146B2 (en) 2012-04-17 2017-12-05 Covidien Lp Surgical system and method of use of the same
US10226190B2 (en) 2009-03-05 2019-03-12 Ingo Flore Diagnostic measuring device
US11559234B2 (en) 2018-09-06 2023-01-24 The Aga Khan University Portable electrocardiography device

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006100676A2 (en) * 2005-03-21 2006-09-28 Health-Smart Limited System for continuous blood pressure monitoring
JP5602629B2 (ja) * 2007-09-07 2014-10-08 フローレ，インゴ 診断用センサユニット
US8386000B2 (en) 2008-09-30 2013-02-26 Covidien Lp System and method for photon density wave pulse oximetry and pulse hemometry
US8433382B2 (en) 2008-09-30 2013-04-30 Covidien Lp Transmission mode photon density wave system and method
TWI439255B (zh) * 2009-04-28 2014-06-01 私立中原大學 Measurement of arrhythmia
US8788001B2 (en) 2009-09-21 2014-07-22 Covidien Lp Time-division multiplexing in a multi-wavelength photon density wave system
US8494604B2 (en) 2009-09-21 2013-07-23 Covidien Lp Wavelength-division multiplexing in a multi-wavelength photon density wave system
US20110218448A1 (en) * 2010-03-03 2011-09-08 Buntic Rudolf F Perfusion detection devices and methods of using the same
RU2469641C2 (ru) * 2011-03-11 2012-12-20 Государственное образовательное учреждение высшего профессионального образования "Самарский государственный аэрокосмический университет имени академика С.П. Королева (национальный исследовательский университет)" (СГАУ) Устройство для определения показателя эластичности артериальных сосудов
JP5874367B2 (ja) 2011-12-13 2016-03-02 富士通株式会社 心拍信号処理装置、および心拍信号処理方法
CN103315709B (zh) * 2013-06-13 2015-06-03 北京豪络科技有限公司 一种有嵌入传感电路用于检测人体生命特征的表带和检测方法
CN103654770B (zh) * 2013-12-03 2015-11-18 上海理工大学 移动心电信号qrs波实时波检测方法及装置
CN104173035A (zh) * 2014-07-22 2014-12-03 北京工业大学 一种便携袖带式健康监测装置及其使用方法
ES2636260T3 (es) * 2015-02-20 2017-10-05 Synergia Medical Dispositivo fotovoltaico de estimulación eléctrica
CN104720773A (zh) * 2015-03-10 2015-06-24 中国科学院电子学研究所 一种手持式的人体多健康参数监护系统
JP6778369B2 (ja) * 2015-03-10 2020-11-04 東京都公立大学法人 生体信号解析システムおよびプログラム
CN106175720A (zh) * 2015-05-06 2016-12-07 深圳迪美泰数字医学技术有限公司 一种生理生化参数监护与记录的方法及装置
JP6537900B2 (ja) * 2015-06-09 2019-07-03 日本光電工業株式会社 医療用装置、生体パラメータ解析方法および生体パラメータ解析プログラム
FR3053237A1 (fr) * 2016-06-30 2018-01-05 Universite D'aix-Marseille Dispositif de detection d'au moins un trouble du rythme cardiaque
KR102244675B1 (ko) 2019-04-26 2021-04-26 연세대학교 산학협력단 경피성 산소분압 센서가 내장된 모바일 디바이스 센서 플랫폼
CN112858445B (zh) * 2021-01-15 2023-03-17 重庆大学 一种基于摩擦起电效应的变压器油老化程度与水分含量自驱动传感系统及检测方法
WO2023019467A1 (zh) * 2021-08-18 2023-02-23 中国人民解放军总医院第二医学中心 多项生理参数检测手套及高血压病症患病风险检测系统
WO2024038688A1 (ja) * 2022-08-18 2024-02-22 ソニーグループ株式会社 情報処理装置、情報処理方法、及びプログラム

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4934382A (en) 1989-07-03 1990-06-19 Barone Jr Richard J Protective sheath with manipulation tabs
US4960126A (en) 1988-01-15 1990-10-02 Criticare Systems, Inc. ECG synchronized pulse oximeter
US5191891A (en) * 1991-09-10 1993-03-09 Ralin, Inc. Portable ECG monitor/recorder
US5309916A (en) 1990-07-18 1994-05-10 Avl Medical Instruments Ag Blood pressure measuring device and method
US6190325B1 (en) * 1998-10-02 2001-02-20 Colin Corporation Blood-pressure monitoring apparatus
US20010012916A1 (en) 1999-12-23 2001-08-09 Klaus Deuter Blood pressure measuring device
US20020087087A1 (en) 1995-11-06 2002-07-04 Colin Corporation Apparatus for measuring pulse-wave propagation velocity
EP1317902A1 (en) 2001-12-10 2003-06-11 Kabushiki Gaisha K-and-S Biological data observation apparatus
US20030109901A1 (en) 2001-12-11 2003-06-12 Wilson Greatbatch Photonic pacemaker-cardiac monitor
US20040116784A1 (en) 2002-12-13 2004-06-17 Intercure Ltd. Apparatus and method for beneficial modification of biorhythmic activity
US20040162493A1 (en) 1999-10-07 2004-08-19 Mills Alexander K. Device and method for noninvasive continuous determination of physiologic characteristics
US7215991B2 (en) * 1993-09-04 2007-05-08 Motorola, Inc. Wireless medical diagnosis and monitoring equipment

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422770D0 (en) * 1984-09-10 1984-10-17 Pulse Time Products Ltd Indicating blood pressure
US4934372A (en) * 1985-04-01 1990-06-19 Nellcor Incorporated Method and apparatus for detecting optical pulses
JPS63186623A (ja) * 1987-01-27 1988-08-02 松下電工株式会社 心拍計
JPH04276235A (ja) * 1991-03-04 1992-10-01 Casio Comput Co Ltd 信号検出装置
JP2544324Y2 (ja) * 1992-09-25 1997-08-20 日本光電工業株式会社 生体情報測定用センサ
JP3223931B2 (ja) * 1992-11-04 2001-10-29 カシオ計算機株式会社 人体接触用電極を備えた電子機器
JPH08257002A (ja) * 1995-03-27 1996-10-08 Nippon Colin Co Ltd 脈波伝播速度測定装置
JP3558431B2 (ja) * 1995-11-27 2004-08-25 コーリンメディカルテクノロジー株式会社 脈波伝播速度測定機能付き自動血圧測定装置
JP3599858B2 (ja) * 1995-11-06 2004-12-08 コーリンメディカルテクノロジー株式会社 脈波伝播速度測定装置
JP4092769B2 (ja) * 1998-04-21 2008-05-28 松下電器産業株式会社 生体モニタ装置
JP4174922B2 (ja) * 1999-07-19 2008-11-05 オムロンヘルスケア株式会社 患者監視装置
US7204250B1 (en) * 1999-12-16 2007-04-17 Compumedics Limited Bio-mask
KR20010096186A (ko) * 2000-04-17 2001-11-07 김종필 통합의료진단장치
JP3785529B2 (ja) * 2000-12-06 2006-06-14 カシオ計算機株式会社 血圧測定システム及び血圧値演算装置
KR20030084290A (ko) * 2002-04-26 2003-11-01 송철규 연속 심장기능 변수 모니터링을 위한 신호처리 방법
JP3988674B2 (ja) * 2003-04-21 2007-10-10 オムロンヘルスケア株式会社 脈波伝播速度情報測定装置
KR100552681B1 (ko) * 2003-04-25 2006-02-20 삼성전자주식회사 수면 무호흡 진단 장치 및 방법

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960126A (en) 1988-01-15 1990-10-02 Criticare Systems, Inc. ECG synchronized pulse oximeter
US4934382A (en) 1989-07-03 1990-06-19 Barone Jr Richard J Protective sheath with manipulation tabs
US5309916A (en) 1990-07-18 1994-05-10 Avl Medical Instruments Ag Blood pressure measuring device and method
US5191891A (en) * 1991-09-10 1993-03-09 Ralin, Inc. Portable ECG monitor/recorder
US7215991B2 (en) * 1993-09-04 2007-05-08 Motorola, Inc. Wireless medical diagnosis and monitoring equipment
US20020087087A1 (en) 1995-11-06 2002-07-04 Colin Corporation Apparatus for measuring pulse-wave propagation velocity
US6190325B1 (en) * 1998-10-02 2001-02-20 Colin Corporation Blood-pressure monitoring apparatus
US20040162493A1 (en) 1999-10-07 2004-08-19 Mills Alexander K. Device and method for noninvasive continuous determination of physiologic characteristics
US20010012916A1 (en) 1999-12-23 2001-08-09 Klaus Deuter Blood pressure measuring device
EP1317902A1 (en) 2001-12-10 2003-06-11 Kabushiki Gaisha K-and-S Biological data observation apparatus
US20030109901A1 (en) 2001-12-11 2003-06-12 Wilson Greatbatch Photonic pacemaker-cardiac monitor
US20040116784A1 (en) 2002-12-13 2004-06-17 Intercure Ltd. Apparatus and method for beneficial modification of biorhythmic activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
International Search Report for PCT/EP2006/002410 Jul. 13, 2006.

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9924886B2 (en) 2005-08-09 2018-03-27 Ingo Flore Medical measuring device
US20080275317A1 (en) * 2005-08-09 2008-11-06 Ok Kyung Cho Medical Measuring Device
US9101264B2 (en) 2006-06-15 2015-08-11 Peerbridge Health, Inc. Wireless electrode arrangement and method for patient monitoring via electrocardiography
US9681825B2 (en) 2006-06-15 2017-06-20 Peerbridge Health, Inc. Wireless electrode arrangement and method for patient monitoring via electrocardiography
US20100056880A1 (en) * 2006-11-23 2010-03-04 Ok Kyung Cho Medical measuring device
US9603521B2 (en) * 2006-11-23 2017-03-28 Ingo Flore Medical measuring device
US20100234701A1 (en) * 2007-09-07 2010-09-16 Ok Kyung Cho Medical measurement device for bioelectrical impedance measurement
US9060700B2 (en) 2007-09-07 2015-06-23 Ingo Flore Medical measurement device for bioelectrical impedance measurement
US10226190B2 (en) 2009-03-05 2019-03-12 Ingo Flore Diagnostic measuring device
US20120310103A1 (en) * 2011-06-02 2012-12-06 Nokia Siemens Networks Oy Heart monitor with user input
US9833146B2 (en) 2012-04-17 2017-12-05 Covidien Lp Surgical system and method of use of the same
US9675264B2 (en) 2013-03-15 2017-06-13 Peerbridge Health, Inc. System and method for monitoring and diagnosing patient condition based on wireless sensor monitoring data
US11559234B2 (en) 2018-09-06 2023-01-24 The Aga Khan University Portable electrocardiography device

Also Published As

Publication number Publication date
CN101170944B (zh) 2010-09-29
WO2006099988A1 (de) 2006-09-28
CA2602269C (en) 2013-07-02
EA200702042A1 (ru) 2008-02-28
CA2602269A1 (en) 2006-09-28
US20080200823A1 (en) 2008-08-21
EP1860999A1 (de) 2007-12-05
CN101170944A (zh) 2008-04-30
ATE452580T1 (de) 2010-01-15
JP2008532719A (ja) 2008-08-21
KR101286402B1 (ko) 2013-07-15
EA013620B1 (ru) 2010-06-30
KR20070113238A (ko) 2007-11-28
DE502006005727D1 (de) 2010-02-04
EP1860999B1 (de) 2009-12-23
JP2014039875A (ja) 2014-03-06
DE102005013429A1 (de) 2006-09-28
JP5748160B2 (ja) 2015-07-15

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