US7019162B2 - Process for preparing 2-fluoro-3-oxoalkylcarboxylic acid ester - Google Patents
Process for preparing 2-fluoro-3-oxoalkylcarboxylic acid ester Download PDFInfo
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- US7019162B2 US7019162B2 US10/451,814 US45181403A US7019162B2 US 7019162 B2 US7019162 B2 US 7019162B2 US 45181403 A US45181403 A US 45181403A US 7019162 B2 US7019162 B2 US 7019162B2
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- acid ester
- oxoalkylcarboxylic
- oxoalkylcarboxylic acid
- fluoro
- reaction mixture
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- 0 CF.[1*]C(C)=O Chemical compound CF.[1*]C(C)=O 0.000 description 6
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/58—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Definitions
- the present invention relates to a process for producing 2-fluoro-3-oxoalkylcarboxylic acid ester, an important intermediate material used in the production of various pharmaceutical or agricultural agents.
- Fluoride-containing dicarbonyl compounds such as 2-fluoro-3-oxoalkylcarboxylic acid ester are of significant importance since they serve as an intermediate material in the production of various pharmaceutical and agricultural agents.
- certain dicarbonyl compounds are subjected to direct fluorination by fluorine gas.
- fluorine gas for example, techniques disclosed in J. Org. Chem., 57, 2196 (1992), International Patent Publication WO94/10120, International Patent Publication WO95/14646, and Japanese Patent Laid-Open Publication No. Hei 9-255611 involve direct fluorination of 3-oxoalkylcarboxylic acid ester with fluorine gas to produce desired 2-fluoro-3-oxoalkylcarboxylic acid ester.
- the present inventors made an attempt to separate the products from the reaction mixture containing differently fluorinated 3-oxoalkylcarboxylic acid esters by using a standard distillation technique. It has proven difficult, however, to purify the desired product since the polyfluorinated 3-oxoalkylcarboxylic acid esters, such as 2,5-difluoro-3-oxoalkylcarboxylic acid ester, are unstable when subjected to heat and can readily decompose to produce hydrogen fluoride.
- polyfluorinated 3-oxoalkylcarboxylic acid esters such as 2,4-difluoro-3-oxoalkylcarboxylic acid ester and 2,2,4-trifluoro-3-oxoalkylcarboxylic acid ester, in addition to their unstability toward heat, have a structure and a molecular weight similar to those of the desired 2-fluoro-3-oxoalkylcarboxylic acid ester and are therefore difficult to efficiently purify by distillation.
- fluorinated 3-oxoalkylcarboxylic acid esters have been used to date as a material in the subsequent processes without being subjected to purification by distillation.
- One such example is a technique disclosed in European Patent 0440372A1 for producing triazole derivatives, compounds often used as a fungicide.
- 2-fluoro-3-oxoalkylcarboxylic acid ester is reacted with amidine.
- 2-fluoro-3-oxoalkylcarboxylic acid ester containing significant amounts of by-products is used as a material for the reaction, not only is the purity of the product reduced, but compounds of unknown structure are also formed. This considerably limits the conditions for the reaction and adds to the difficulty in producing the desired product.
- fluorination of 3-oxoalkylcarboxylic acid ester is carried out while formation of 2,5-difluoro-3-oxoalkylcarboxylic acid ester by-product is controlled and by-products such as 2,4-difluoro-3-oxoalkylcarboxylic acid ester and 2,2,4-trifluoro-3-oxyalkylcarboxylic acid ester are selectively removed.
- the present inventors also discovered that the excessively fluorinated by-products such as 2,4-difluoro-3-oxoalkylcarboxylic acid ester can be selectively removed from a mixture of fluorinated 3-oxoalkylcarboxylic acid esters by repeating washing with water in addition to the washing previously provided in the conventional process, which only requires an amount of water sufficient to remove the resulting hydrogen fluoride.
- the present inventors have devised a method for efficiently purifying 2-fluoro-3-oxoalkylcarboxylic acid ester at high yield by developing a washing process and a distillation process of the fluorinated 3-oxoalkylcarboxylic acid ester. The present inventors have thus completed the present invention.
- the present invention concerns a process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester represented by the following general formula (2): wherein R 1 represents alkyl or alkenyl group and R2 represents protective group of carboxyl group; the process involving fluorinating with fluorine gas a 3-oxoalkylcarboxylic acid ester represented by the following general formula (1): wherein R 1 and R 2 are the same as defined above.
- This process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3 wt % or higher.
- the present invention provides a process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester, characterized in that, following the removal of hydrogen fluoride in the aforementioned process, 2-fluoro-3-oxoalkylcarboxylic acid ester is separated from the reaction mixture by distillation.
- the present invention provides a process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester at a high purity, characterized in that, subsequent to the fluorination, 2,4-difluoro-3-oxoalkylcarboxylic acid ester by-product is removed by washing with water, which is carried out by using at least 3 or more times as much water as the amount of reaction mixture.
- the present invention provides a process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester at a high purity, characterized in that 2,4-difluoro-3-oxoalkylcarboxylic acid ester by-product is removed from the reaction mixture obtained in the above-described process to an amount of 5.0 wt % or less, and the above-described process is subjected to distillation under reduced pressure.
- 3-oxoalkylcarboxylic acid ester to serve as a reaction material is a ⁇ -dicarbonyl compound having an active methylene group and represented by the general formula (1) above.
- R 1 in the general formula (1) represents a substituent that comprises a hydrocarbon having 1 to 10 carbon atoms, such as an alkyl group and an alkenyl group.
- substituents include alkyl groups such as methyl, ethyl, propyl, isopropyl, cyclopropyl, butyl, isobutyl, hexyl, cyclohexyl, and octyl, and alkenyl groups such as propenyl, butenyl, and hexenyl.
- Hydrogen atoms present in the substituent R 1 may or may not be substituted with fluorine atoms.
- R 2 serving as a protective group of carboxylic acid, may be any organic compound that can form an ester bond.
- R 2 include, but are not limited to, alkyl, alkenyl, and aryl groups.
- Examples of preferred 3-oxoalkylcarboxylic acid ester include 3-oxobutyric acid ester and 3-oxopentanoic acid ester.
- 3-oxoalkylcarboxylic acid ester of the general formula (1) forms an ester having a lower alkyl group such as a methyl ester and an ethyl ester.
- a first step of the process of the present invention is to fluorinate 3-oxoalkylcarboxylic acid ester with fluorine gas.
- 3-oxoalkylcarboxylic acid ester is directly fluorinated with a fluorine gas that has been diluted with nitrogen or other inert gases.
- the fluorination step can be properly carried out to prepare a desired reaction mixture: 3-oxoalkylcarboxylic acid ester is first placed in a reactor equipped with a stirrer and a thermometer. While the ester is being stirred, bubbles of a fluorine gas diluted with nitrogen to a concentration of approximately 10% are introduced to carry out the reaction.
- the reaction generally takes about 5 to 40 hours at temperatures of 0 to 15° C. though the time it takes for the reaction to complete may vary depending on the amount of the reaction mixture and the rate of bubbling with fluorine gas.
- Techniques for fluorination include, but are not limited to, batch processes in which fluorine gas is blown into 3-oxoalkylcarboxylic acid ester or in which a solution into which fluorine gas has been dissolved is added, as well as continuous processes in which 3-oxoalkylcarboxylic acid ester is continuously blown into a reaction container along with fluorine gas or in which 3-oxalkylcarboxylic acid ester, along with fluorine gas, is continuously passed through a reaction tube.
- the amount of polyfluorinated 3-oxoalkylcarboxylic acid esters such as 2,5-difluoro-3-oxoalkylcarboxylic acid ester, which are by-products formed as a result of excessive fluorination during the fluorination process, are minimized since they can be thermally decomposed in the subsequent distillation process to produce hydrogen fluoride, which causes the decomposition of 2-fluoro-3-oxoalkylcarboxylic acid ester.
- polyfluorinated 3-oxoalkylcarboxylic acid ester by-products other than 2,5-difluoro-3-oxoalkylcarboxylic acid ester include 2,2-difluoro-3-oxoalkylcarboxylic acid ester, 2,4-difluoro-3-oxoalkylcarboxylic acid ester, 2,2,4-trifluoro-3-oxoalkylcarboxylic acid ester, and 2,2,5-trifluoro-3-oxoalkylcarboxylic acid ester.
- the rate of the reaction can be determined by sampling the reaction mixture as desired and performing gas chromatography analysis so that the concentration of 3-oxoalkylcarboxylic acid ester, serving as the material for the reaction, in the fluorination mixture is maintained 3 wt % or above, and preferably, 10 wt % or above while the molar ratio of the 2,5-difluoro-3-oxoalkylcarboxylic acid ester to 2-fluoro-3-oxoalkylcarboxylic acid ester is kept at a value of 0.05 or below, and preferably, at a value of 0.01 or below.
- the concentration of 3-oxoalkylcarboxylic acid ester in the fluorination mixture at 3 wt % or above, the generation of the polyfluorinated 3-oxoalkylcarboxylic acid ester by-products including 2,5-difluoro-3-oxoalkylcarboxylic acid ester can be minimized and, as a result, yield of 2-fluoro-3-oxoalkylcarboxylic acid ester can be increased.
- the concentration of 3-oxoalkylcarboxylic acid ester in the fluorination mixture is less than 3 wt %, then the generation of 2,5-difluoro-3-oxoalkylcarboxylic acid ester proceeds.
- the molar ratio of the 2,5-difluoro-3-oxoalkylcarboxylic acid ester to 2-fluoro-3-oxoalkylcarboxylic acid ester exceeds 0.05, the resultant 2-fluoro-3-oxoalkylcarboxylic acid ester is further fluorinated to rapidly produce impurities, resulting in a reduction in the amount of 2-fluoro-3-oxoalkylcarboxylic acid ester.
- a second step of the process of the present invention is to remove the hydrogen fluoride by-product from the reaction mixture obtained by the fluorination of 3-oxoalkylcarboxylic acid ester.
- reaction solution is washed with water and one in which the reaction solution is distilled under reduced pressure.
- hydrogen fluoride is produced in an amount equal to that of the reacted fluorine gas. This hydrogen fluoride is typically dissolved in the reaction solution.
- the resultant hydrofluoric acid is removed with water in the form of hydrofluoric acid.
- the process of the present invention further involves even more effective washing with water so that the unwanted by-products such as 2,4-difluoro-3-oxoalkylcarboxylic acid ester, 2,5-difluoro-3-oxoalkylcarboxylic acid ester, and 2,2,4-trifluoro-3-oxoalkylcarboxylic acid ester can be selectively eliminated.
- a water-insoluble organic solvent may be added to the reaction mixture although the reaction mixture may be washed directly with water without using any solvent.
- organic solvent examples include hydrocarbons such as pentane, hexane, cyclohexane, and octane; halogenated hydrocarbons such as dichloromethane, chloroform, and 1,2-dichloroethane; aromatic compounds such as benzene, toluene, and xylene; ethers such as diethylether, diisopropylether, and diphenylether; esters such as methyl acetate, ethyl acetate, andbutyl acetate; and nitriles such as propionitrile, and butyronitrile.
- organic solvents may be used either individually or as a mixture of two or more solvents.
- the desired 2-fluoro-3-oxoalkylcarboxylic acid ester can be obtained as free a product from water soluble by-products by distilling out the organic solvent from the organic phase remaining after the washing with water.
- water may be used in the washing process in any amount that is three or more times larger than the amount of the reaction mixture, the amount of water is preferably 3 to 20 times, and more preferably, 3 to 10 times the amount of the reaction mixture.
- the washing may be repeated as many times as desired by taking into consideration the amount of water used.
- washing with water may be carried out at any temperature between 0 and 60° C., it is preferably carried out at temperatures of 5 to 40° C.
- the additional washings following the removal of the hydrofluoric acid can selectively reduce the 2,4-difluoro-3-oxoalkylcarboxylic acid ester, an unwanted impurity, present in the resulting mixture that also contains 2-fluoro-3-oxoalkylcarboxylic acid ester down to as small an amount as 5 wt % or less, despite the fact that 2,4-difluoro-3-oxoalkylcarboxylic acid ester has the physical and chemical properties similar to those of 2-fluoro-3-oxoalkylcarboxylic acid ester.
- the resulting mixture can thus be used directly as a material in ring formation or other chemical reactions for producing medical and agricultural agents.
- the distillation under reduced pressure for removing hydrogen fluoride may be carried out by maintaining the reaction mixture at temperatures of 50° C. or below, and more preferably, at temperatures of 40° C. or below. In this manner, hydrogen fluoride can be effectively removed.
- the distillation is carried out while the pressure is gradually decreased from atmospheric pressure to about 4.00 Kpa (30 torr) depending on the amount of hydrogen fluoride present.
- the distillation process is typically carried out in 3 to 15 hours while it may take any length of time.
- Another technique used for the removal of hydrogen fluoride is distillation using an azeotropic agent to form an azeotrope.
- the compound that can form an azeotrope with hydrogen fluoride include ethers such as dimethylether, diethylether, diisopropylether; fluorinated hydrochlorocarbons such as trifluoroethylchloride, Freon-12, and Freon-22; and hydrocarbons such as butane and isobutane.
- the azeotropic agent may be added to the reaction mixture or, alternatively, bubbles of the azeotropic agent may be continuously introduced into the mixture.
- a basic compound may optionally be added to the reaction mixture to further enhance the removal of hydrogen fluoride.
- Such compounds include hydroxides, carbonates, and bicarbonates of alkali metals and alkali earth metals.
- Hydrogen fluoride is preferably removed as much as possible and is typically reduced to 2.0 wt % or less and, preferably, to 1.0 wt % or less with respect to the amount of the reaction mixture.
- the reaction mixture containing 2.0 wt % or more of hydrogen fluoride is unfavorable since such a mixture can lead to a decrease in the purity and yield of the resulting 2-fluoro-3-oxoalkylcarboxylic acid ester when subjected to the subsequent separation process by distillation.
- the next step in the process of the present invention is to distill the reaction mixture from which hydrogen fluoride has been removed and separate 2-fluoro-3-oxoalkylcarboxylic acid ester, a desired product.
- the mixture containing 2-fluoro-3-oxoalkylcarboxylic acid ester can further be purified by distillation.
- the mixture containing 2-fluoro-3-oxoalkylcarboxylic acid ester contains 5 wt % or more of 2,4-difluoro-3-oxoalkylcarboxylic acid ester, not only do their close boiling points make the purification process by distillation difficult, but also the decomposition of 2,4-difluoro-3-oxoalkylcarboxylic acid ester is increased. As a result, the yield of 2-fluoro-3-oxoalkylcarboxylic acid ester with a purity of 95 wt % or higher, which is obtained as the main fraction, is significantly reduced.
- Distillation under reduced pressure is suited for the purpose of purifying 2-fluoro-3-oxoalkylcarboxylic acid ester.
- This process is preferably carried out under a pressure of 4.00 KPa (30 torr) or lower and at temperatures of 150° C. or lower, more preferably at temperatures of 130° C. or lower, and still more preferably at temperatures of 125° C. or lower, while temperatures are preferably kept as low as possible. If the temperature exceeds 150° C., 3-oxoalkylcarboxylic acid ester, as well as fluorinated derivatives thereof, tends to become unstable and may become susceptible to decomposition.
- 3-oxoalkylcarboxylic acid ester is left unreacted when the fluorination process is terminated at an early stage.
- the step of purification by distillation helps prevent this 3-oxoalkylcarboxylic acid ester from contaminating the product.
- 3-oxoalkylcarboxylic acid ester separated in the purification step may be returned to the fluorination step for recycling.
- 2,2,4-TFOP methyl ester of 2,2,4-trifluoro-3-oxopentanoic acid.
- the reaction mixture was transferred to a polyethylene separating funnel.
- approximately 1 kg of the fluorinated reaction mixture approximately 1 L of water and approximately 1 L of chloroform were added.
- the resulting mixture was thoroughly shaken at room temperature (15–20° C.) and was then allowed to stand still until the mixture was separated into two layers. Subsequently, approximately 1 L of additional water was added to the chloroform layer and the same process was repeated. This washing process was repeated 4 times in total. After washing, the solvent was removed from the chloroform layer by distillation to obtain a crude product, which was then subjected to gas chromatography analysis.
- the process was carried out in the same manner as in Example 2, except that the reaction mixture from which hydrofluoric acid had been completely removed was washed with water 6 times in total.
- the results of the gas chromatography analysis performed on the resulting product revealed that the washed product was composed of 4.7 wt % MOP, 87.8 wt % MFOP, 7.1 wt % 2,2-DFOP, 0.3 wt % 2,4-DFOP, 0.1 wt % 2,5-DFOP, 0.0 wt % 2,2,4-TFOP, and 0.0 wt % HF.
- the weight of the product remaining after 6 times of the washing was about 416 g.
- the process was carried out in the same manner as in Example 2, except that the washing of the fluorinated reaction mixture was carried out at temperatures of 5 to 10° C.
- the results of the gas chromatography analysis performed on the resulting product revealed that the washed product was composed of 5.3 wt % MOP, 85.5 wt % MFOP, 7.6 wt % 2,2-DFOP, 0.7 wt % 2,4-DFOP, 0.8 wt %2,5-DFOP, 0.0 wt %2,2,4-TFOP, and 0.0 wt % HF.
- the weight of the product remaining after 4 times of the washing was about 461 g.
- the reaction mixture was transferred to a polyethylene separating funnel. To 1 kg of the fluorinated reaction mixture, approximately 1 L of water and approximately 1 L of chloroform were added. The resulting mixture was thoroughly shaken at room temperature (15–20° C.) and was then allowed to stand still until the mixture was separated into two layers. After washing, the solvent was removed from the chloroform layer by distillation to obtain a crude product, which was then subjected to gas chromatography analysis.
- the weight of the crude product remaining after the washing to remove hydrofluoric acid was about 611 g.
- the process was carried out in the same manner as in Comparative Example 1, except that another 1 L of water was added to the reaction mixture after the removal of hydrofluoric acid for an additional washing.
- the results of the gas chromatography analysis performed on the resulting product revealed that the washed product was composed of5.6 wt % MOP, 77.8 wt % MFOP, 8.1 wt % 2,2-DFOP, 7.3 wt % 2,4-DFOP, 1.2 wt % 2,5-DFOP, 0.0 wt % 2,2,4-TFOP, and 0.0 wt % HF.
- the weight of the crude product remaining after the washing was about 530 g.
- the first fraction weighed 8.1 g and contained 0.8 wt % of MFOP.
- the fraction composed mainly of MOP weighed 5.0 g and contained 14.6 wt % MFOP.
- the fraction composed mainly of MFOP weighed 85.2 g and contained 98.2 wt % MFOP.
- the material balance of MFOP was 98 wt %, indicating little decomposition of the compound.
- Example 5 Purification process by distillation was carried out in the same manner as in Example 5, except that 120 g of the liquid obtained in Comparative Example 2 in a still was used.
- Each fraction was then analyzed by gas chromatography to determine the concentration of MFOP.
- the first fraction weighed 7.9 g and contained 0.7 wt % of MFOP.
- the crude product obtained through the reaction contained 14.6 wt % MOP, 43.2 wt % MFOP, 4.9 wt % 2,2-DFOP, 20.8 wt % 2,4-DFOP, 0.5 wt % 2,5-DFOP, 0.3 wt % 2,2,4-TFOP, and 13.1 wt % hydrogen fluoride (HF).
- the molar ratio of 2,5-DFOP to MFOP was 0.01.
- Each fraction was then analyzed by gas chromatography to determine the concentration of MFOP.
- the first fraction weighed 10.3 g and contained 0.6 wt % of MFOP.
- the fraction composed mainly of MOP weighed 21.3 g and contained 5.5 wt % MFOP.
- the fraction composed mainly of MFOP weighed 80.2 g and contained 95.3 wt % MFOP.
- the residual fraction, weighing 8.2 g contained 23.5 wt % MFOP.
- the material balance of MFOP was 99 wt %, indicating little decomposition of the compound.
- the obtained liquid in a still was subjected to a batch distillation process in the same manner as in Example 5 in which the pressure was first reduced from atmospheric pressure to 2.67 KPa (20 torr) with the still temperature maintained at 103° C. and after 4 hours, the pressure was further reduced to 1.33 KPa (10 torr) with the still temperature maintained at 87° C. The distillation was ended after 13 hours.
- the liquid was separated into four fractions: a first fraction composed mainly of low-boiling point products; a fraction composed mainly of MOP; a main fraction composed mainly of MFOP; and a residual fraction remaining in the still and composed mainly of high-boiling point products.
- the first fraction weighed 15.9 g and contained 2.9 wt % of MFOP.
- the fraction composed mainly of MOP weighed 3.1 g and contained 13.5 wt % MFOP.
- the fraction composed mainly of MFOP weighed 48.7 g and contained 98.8 wt % MFOP.
- the residual fraction, weighing 52.2 g, contained 16.0 wt % MFOP. Coloring of the liquid in the still, decomposition of the composition, and generation of heavy fraction were observed over the course of the distillation process and the material balance of MFOP was decreased to 85 wt %.
- Example 2 As with Example 1, 5000 g MOP was loaded and bubbles of 10% fluorine gas diluted with nitrogen were introduced into the reactor to carry out the reaction. The reaction was allowed to proceed for 32 hours while the temperature was maintained at 0° C. The reaction was then terminated and the resulting reaction mixture was analyzed by gas chromatography (PEG 20M, 3 m and OV-1, 3 m).
- the liquid remaining in a still that was obtained in the same manner as in Example 5 was subjected to a batch distillation process in which the pressure was first reduced from atmospheric pressure to 2.67 KPa (20 torr) with the still temperature maintained at 103° C. and after 4 hours, the pressure was further reduced to 1.33 KPa (10 torr) with the still temperature maintained at 87° C. The distillation was ended after 15 hours.
- the liquid was separated into four fractions: a first fraction composed mainly of low-boiling point products; a fraction composed mainly of MOP; a main fraction composed mainly of MFOP; and a residual fraction remaining in the still and composed mainly of high-boiling point products.
- the first fraction weighed 15.5 g and contained 0.3 wt % of MFOP.
- the fraction composed mainly of MOP weighed 2.4 g and contained 26.2 wt % MFOP.
- the fraction composed mainly of MFOP weighed 71.1 g and contained 98.5 wt % MFOP.
- the residual fraction, weighing 31.1 g, contained 23.1 wt % MFOP. Coloring of the liquid in the still, decomposition of the composition, and generation of heavy fraction were observed over the course of the distillation process and the material balance of MFOP was decreased to 92 wt %.
- the present invention makes it possible to selectively remove unwanted by-products generated during fluorination of 3-oxoalkylcarboxylic acid ester by fluorine gas, such as 2,4-difluoro-3-oxoalkylcarboxylic acid ester, 2,5-difluoro-3-oxoalkylcarboxylic acid ester, and 2,2,4-trifluoro-3-oxoalkylcarboxylic acid ester, so that 2-fluoro-3-oxoalkylcarboxylic acid ester can be purified at high efficiency.
- fluorine gas such as 2,4-difluoro-3-oxoalkylcarboxylic acid ester, 2,5-difluoro-3-oxoalkylcarboxylic acid ester, and 2,2,4-trifluoro-3-oxoalkylcarboxylic acid ester, so that 2-fluoro-3-oxoalkylcarboxylic acid ester can be purified at high
- the present invention brings about significant improvements in the quality of pharmaceutical agents derived from 2-fluoro-3-oxoalkylcarboxylic acid ester as well as a significant reduction in the production cost and thus can lead to a substantial economic impact.
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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JP2000394203A JP4717204B2 (ja) | 2000-12-26 | 2000-12-26 | 2−フルオロ−3−オキソアルキルカルボン酸エステルの製造方法 |
JP2000394202A JP4717203B2 (ja) | 2000-12-26 | 2000-12-26 | 2−フルオロ−3−オキソアルキルカルボン酸エステルの精製方法 |
JP2000-394203 | 2000-12-26 | ||
JP2000-394202 | 2000-12-26 | ||
PCT/JP2001/011320 WO2002051789A1 (fr) | 2000-12-26 | 2001-12-25 | Procede de preparation d'esters d'acide 2-fluoro-3-oxoalkylcarboxylique |
Publications (2)
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US20040054217A1 US20040054217A1 (en) | 2004-03-18 |
US7019162B2 true US7019162B2 (en) | 2006-03-28 |
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US10/451,814 Expired - Fee Related US7019162B2 (en) | 2000-12-26 | 2001-12-25 | Process for preparing 2-fluoro-3-oxoalkylcarboxylic acid ester |
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US (1) | US7019162B2 (ja) |
EP (1) | EP1362842B1 (ja) |
AT (1) | ATE356795T1 (ja) |
DE (1) | DE60127308D1 (ja) |
WO (1) | WO2002051789A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20040249190A1 (en) * | 2001-09-27 | 2004-12-09 | Norihisa Kondo | Method of purifying and separating 2-fluoro-3-oxoalkylcarboxylic acid ester |
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CN102603530A (zh) * | 2012-02-21 | 2012-07-25 | 南通市东昌化工有限公司 | 氟代丙酰乙酸甲酯的生产方法 |
CN108863834B (zh) * | 2018-08-13 | 2020-12-15 | 信阳师范学院 | 一种2-氟代-1,3-二羰基化合物的合成新方法 |
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JPH09255611A (ja) | 1996-03-26 | 1997-09-30 | Chichibu Onoda Cement Corp | 含フッ素ジカルボニル化合物の製造方法 |
WO2001030740A1 (fr) | 1999-10-26 | 2001-05-03 | Daikin Industries Ltd. | Procede de production de composes a base de fluorodicarbonyle |
JP2001354622A (ja) | 2000-04-11 | 2001-12-25 | F-Tech Inc | 2−フルオロ−3−オキソアルキルカルボン酸エステルの精製分離方法 |
Family Cites Families (1)
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WO1995014646A1 (en) * | 1993-11-20 | 1995-06-01 | Bnfl Fluorochemicals Ltd | The preparation of dicarbonyls |
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2001
- 2001-12-25 EP EP01272302A patent/EP1362842B1/en not_active Expired - Lifetime
- 2001-12-25 DE DE60127308T patent/DE60127308D1/de not_active Expired - Lifetime
- 2001-12-25 WO PCT/JP2001/011320 patent/WO2002051789A1/ja active IP Right Grant
- 2001-12-25 AT AT01272302T patent/ATE356795T1/de not_active IP Right Cessation
- 2001-12-25 US US10/451,814 patent/US7019162B2/en not_active Expired - Fee Related
Patent Citations (5)
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JPH09255611A (ja) | 1996-03-26 | 1997-09-30 | Chichibu Onoda Cement Corp | 含フッ素ジカルボニル化合物の製造方法 |
WO1997035824A1 (fr) | 1996-03-26 | 1997-10-02 | F-Tech, Inc. | Procede pour preparer des composes dicarbonyle fluores |
EP0891962A1 (en) | 1996-03-26 | 1999-01-20 | F-Tech Inc. | Process for the preparation of fluorinated dicarbonyl compounds |
WO2001030740A1 (fr) | 1999-10-26 | 2001-05-03 | Daikin Industries Ltd. | Procede de production de composes a base de fluorodicarbonyle |
JP2001354622A (ja) | 2000-04-11 | 2001-12-25 | F-Tech Inc | 2−フルオロ−3−オキソアルキルカルボン酸エステルの精製分離方法 |
Non-Patent Citations (1)
Title |
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Chambers et al, Tetrahedron, Direct Fluorination of 1,3-Dicarbonyl Compounds, 1995, 52(1), pp. 1-8. * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040249190A1 (en) * | 2001-09-27 | 2004-12-09 | Norihisa Kondo | Method of purifying and separating 2-fluoro-3-oxoalkylcarboxylic acid ester |
US7220878B2 (en) * | 2001-09-27 | 2007-05-22 | Tosoh F-Tech, Inc. | Method of purifying and separating 2-fluoro-3-oxoalkylcarboxylic acid ester |
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Publication number | Publication date |
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ATE356795T1 (de) | 2007-04-15 |
EP1362842A4 (en) | 2005-06-29 |
DE60127308D1 (de) | 2007-04-26 |
EP1362842B1 (en) | 2007-03-14 |
US20040054217A1 (en) | 2004-03-18 |
WO2002051789A1 (fr) | 2002-07-04 |
EP1362842A1 (en) | 2003-11-19 |
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