US6586636B2 - Aldol condensation - Google Patents
Aldol condensation Download PDFInfo
- Publication number
- US6586636B2 US6586636B2 US09/861,529 US86152901A US6586636B2 US 6586636 B2 US6586636 B2 US 6586636B2 US 86152901 A US86152901 A US 86152901A US 6586636 B2 US6586636 B2 US 6586636B2
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- United States
- Prior art keywords
- process according
- catalyst
- alkali metal
- aldehyde
- hydrogenation
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- Expired - Fee Related, expires
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/02—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the alkali- or alkaline earth metals or beryllium
- B01J23/04—Alkali metals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
- C07C29/141—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group with hydrogen or hydrogen-containing gases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
- B01J21/06—Silicon, titanium, zirconium or hafnium; Oxides or hydroxides thereof
- B01J21/08—Silica
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
Definitions
- This invention relates to aldol condensation and in particular to the condensation of straight chain aldehydes such as propanal, butanal, or hexanal.
- aldol condensation of propanal or butanal is an important step in the production of oxo alcohols such as 2-ethyl hexanol.
- oxo alcohols such as 2-ethyl hexanol.
- butanal is typically condensed using an aqueous caustic catalyst at a temperature of the order of 80 to 140° C. to give 2-ethyl hexenal which is then hydrogenated to 2-ethyl hexanol.
- U.S. Pat. No. 5,453,412 and U.S. Pat. No. 5,498,587 describe the hydrogenation of butanal using certain copper catalysts containing sodium oxide at relatively low temperatures, below 160° C. We have found that higher temperatures are necessary in order to effect aldol condensation with solid base catalysts. Thus under the conditions described in the Examples of those U.S. patents, essentially no aldol condensation took place.
- the present invention provides a process for the production of unsaturated aldehydes by the aldol condensation of straight chain aldehydes by contacting the aldehyde in the vapour phase with a particulate catalyst comprising at least one basic alkali metal compound supported on an inert substrate at a temperature above 175° C.
- Suitable catalysts are basic sodium, potassium, or cesium compounds such as oxides hydroxides or carbonates supported on a material such as carbon, silica, alumina, a clay, silicalite or a zeolite.
- Preferred catalysts are alkali metal compounds supported on silica, especially potassium or sodium supported on silica.
- the potassium and sodium catalysts appear to have high activity and are the most selective.
- the catalyst preferably contains 0.1 to 25%, preferably 0.4 to 18%, by weight of the alkali metal.
- the support preferably is in the form of particles having maximum and minimum dimensions in the range 0.5 to 10 mm, preferably 1 to 4 mm, and having a BET surface area in the range 50 to 500 m 2 /g.
- the catalyst is preferably made by impregnating the support particles with an aqueous solution of an alkali metal compound that is basic or decomposes to a basic compound upon heating, for example an alkali metal hydroxide, acetate, oxalate, nitrate or carbonate, followed by drying and calcination if necessary to effect decomposition to a basic compound.
- the reaction is effected at temperatures above 175° C., particularly above 200° C., and preferably below 450° C., particularly in the range 200 to 350° C. As the temperature increases the activity increases but the selectivity tends to decrease, often with the production of hydrogenated products.
- the aldehyde is preferably a straight chain aldehyde containing 2 to 8 carbon atoms, preferably, propanal, butanal, or hexanal.
- the activity of the catalyst tends to decrease through the deposition of carbon as a result of side reactions.
- the catalyst may be periodically regenerated by burning off the carbon by heating in an oxygen-containing atmosphere, e.g. air or oxygen or air diluted with an inert gas such as nitrogen.
- the catalyst may be disposed as a fixed bed or a fluidised bed may be employed. In the latter case a portion of the catalyst may be continuously withdrawn and regenerated and returned to the reaction zone.
- the main product of the condensation is an unsaturated aldehyde, e.g. 2-ethyl hex-2-enal in the case of condensation of butanal, or 2-butyl oct-2-enal in the case of hexanal.
- This may be effected by passing the products, possibly after separation of the starting aldehyde that has not reacted, together with hydrogen, through a bed of a suitable hydrogenation catalyst, such as copper or a platinum group metal, on a suitable support.
- the temperature of the hydrogenation is effected will often be below that used for the aldol condensation.
- the reaction mixture from the aldol condensation may be cooled to the desired hydrogenation temperature by addition of a suitable quench gas, such as cool hydrogen.
- separation of the condensation product from the feed aldehyde prior to hydrogenation will generally not be necessary.
- the bypass aldehyde may be cooled so that it may be used as part or all of the quench gas. Where such a bypass is employed, variation of the amount of bypassing aldehyde may be used to control the relative proportions of the products, e.g. to compensate for declining activity of the base catalyst.
- the primary product from the condensation is the unsaturated aldehyde, e.g. 2-ethyl hex-2-enal or 2-butyl oct-2-enal.
- the desired product is not the corresponding alcohol but is the corresponding saturated aldehyde, e.g. 2-ethyl hexanal or 2-butyl octanal.
- the unsaturated aldehyde may be hydrogenated to the saturated aldehyde using a hydrogenation catalyst, such as palladium, that effects hydrogenation of the carbon—carbon double bond but does not effect hydrogenation of the carbonyl group.
- the base catalyst may be a mixture of separate particles of base and hydrogenation catalyst, or may be particles of the support impregnated with both a base and a material having hydrogenation activity.
- a base/hydrogenation catalyst may be a mixture of separate particles of base and hydrogenation catalyst, or may be particles of the support impregnated with both a base and a material having hydrogenation activity.
- the condensation activity of the catalyst may decrease relatively rapidly. Therefore it is preferred to effect such condensation and hydrogenation in separate stages, e.g. by using a bed of the condensation catalyst, followed by a bed of the hydrogenation catalyst.
- the condensation catalyst is free from components, such as copper, and Group VIII metals, giving hydrogenation activity.
- a series of catalysts were made by impregnating a gel silica in the form of spheres of diameter in the range 2-4 mm having a purity of over 99%, a total surface area of about 300-350 m 2 /g, and a pore volume of 1.04 cm 3 /g with 76% of the pore volume provided by pores having a diameter in the range 7-23 nm with aqueous solutions of alkali metal nitrates and calcining at 450° C. for 3 hours to obtain catalysts containing various loadings of the alkali metal oxide.
- the catalysts were tested for the aldol condensation of butanal at varying temperatures by passing a mixture of butanal at a liquid flow rate of 0.33 ml/min entrained in nitrogen at a gas flow rate of 250 ml/min through a fixed bed of 10 ml of the catalyst at a pressure of 3 bar gauge.
- the products were analysed by gas chromatography-mass spectroscopy.
- the conversion is the number of moles of n-butanal reacted as a percentage of the number of moles of n-butanal in the feed
- the selectivity is two times the number of moles of aldol condensation products as a percentage of the number of moles of n-butanal reacted where the aldol condensation products are cis-2-ethyl hex-2-enal and trans-2-ethyl hex-2-enal (which were the major aldol condensation products), and the hydrogenated derivatives thereof, i.e. 2-ethyl hexanal and 2-ethyl hexanol.
- Examples 1-3 different alkali metals were employed with the catalyst containing 4% by weight of the alkali metal as alkali metal oxide. In Examples 4 and 5 different amounts of alkali metal were used so that the molar loading was the same (0.3 mmoles per g of catalyst) as in Example 1. In Example 6, Example 2 was repeated with a higher loading of potassium. In Examples 1-6 the aldol condensation was effected at 200° C.
- Example 7-8 the catalyst of Example 5 was tested at different temperatures to show the effect of temperature on selectivity.
- the aldol condensation of n-butanal followed by hydrogenation was effected using a 3 ml bed of the catalyst of Example 3 crushed to a particle size of 0.6 to 1 mm, followed by a 3 ml bed of a copper oxide/zinc oxide hydrogenation catalyst made by co-precipitation and containing 35% by weight of copper oxide.
- This hydrogenation catalyst was likewise crushed to a particle size of 0.6 to 1 mm.
- the hydrogenation catalyst was reduced in a current of dilute hydrogen (10% by volume of hydrogen in nitrogen) at 160° C. over a period of 24 hours.
- n-Butanal and hydrogen were fed through the sodium oxide on silica catalyst which was maintained at 350° C. and then the reaction products fed through the hydrogenation catalyst which was maintained at 130° C.
- a series of experiments were performed with different feed rates and pressures as set out in the following table. In all the experiments, the feed was continued for a period of 24 hours and the reaction products monitored.
- the aldol condensation of n-butanal was effected using a 3 ml bed of the catalyst of Example 3 crushed to a particle size of 0.6 to 1 mm.
- n-Butanal (0.05 ml liquid/min) and hydrogen (42 ml/min) at a pressure of 7 bar gauge were continuously passed through to the catalyst which was maintained at 350° C. After various times on-line, samples of the products were analysed by gas chromatography.
- aldol is two times the number of moles of aldol condensation products as a percentage of the number of moles of n-butanal reacted where the aldol condensation products are cis-2-ethyl hex-2-enal and trans-2-ethyl hex-2-enal and the hydrogenated derivatives thereof, i.e. 2-ethyl hexanal and 2-ethyl hexanol.
- aldol is the sum of the number of moles of cis-2-ethyl hex-2-enal and trans-2-ethyl hex-2-enal as a percentage of the total number of moles of aldol condensation products.
- Example 16 The procedure of Example 16 was repeated but using a catalyst containing 4% by weight of sodium and 0.1 % by weight of palladium obtained by the method described in Example 1 but including palladium nitrate in the aqueous solution used to impregnate the gel silica spheres. The results are shown in the following table.
- the major aldol condensation product was 2-ethyl hexanal, but less than 2% of the butanal fed was hydrogenated to butanol and 2-ethyl hexanol, thus demonstrating the selective hydrogenation activity of palladium.
- the conversion although initially higher than that of Example 16, rapidly decreased indicating deactivation of the catalyst.
- Example 17 The procedure of Example 17 was repeated. After about 174 hours operation at 350° C. at a variety of pressures and hydrogen flow rates, by which time the conversion, at 5 bar and a hydrogen flow rate of 25 ml/min, had fallen to about 20% and the selectivity to about 52%, the catalyst was regenerated by replacing the flow of hydrogen and butanal by a mixture of 2% by volume oxygen and 98% by volume nitrogen at temperature of 350° C., a pressure of 5 bar gauge and at a rate of 100 ml/min for 6.5 hours. The reaction was re-commenced at the lower temperature of 300° C. at 5 bar gauge with a hydrogen flow rate of 50 ml/min. After two hours the conversion was about 48% but dropped to about 5% after 23 hours.
- the catalyst was again regenerated by the above procedure for 6.5 hours and then the reaction re-commenced at the lower temperature of 250° C. at 5 bar gauge and a hydrogen flow rate of 50 ml/min.
- the conversion after 2 hours was about 15% but dropped to about 9% after 23 hours.
- Example 17 The procedure of Example 17 was repeated but using a catalyst containing 4% by weight of sodium as sodium oxide and 0.5% by weight of palladium made the same procedure as described above.
- the reaction was effected at 200° C. at a pressure of 5 bar gauge and a hydrogen flow rate of 50 ml/min.
- the conversion and selectivity dropped from about 36% and 84% respectively after 2 hours to about 9% and 52% respectively after 24 hours.
- the aldol condensation of n-hexanal followed by hydrogenation was effected using a 3 ml bed of the catalyst of Example 3 crushed to a particle size of 0.6 to 1 mm, followed by a 3 ml bed of a copper oxide/zinc oxide hydrogenation catalyst made by co-precipitation and containing 35% by weight of copper oxide.
- This hydrogenation catalyst was likewise crushed to a particle size of 0.6 to 1 mm.
- the hydrogenation catalyst was reduced in a current of dilute hydrogen (10% by volume of hydrogen in nitrogen) supplied at a rate of 50 ml/min at a pressure of 3 bar gauge at 140° C. over a period of 24 hours.
- n-Hexanal and hydrogen were fed to the sodium oxide on silica catalyst which was maintained at 350° C. and then the reaction products fed through the hydrogenation catalyst which was maintained at 259° C.
- the initial conditions were a pressure of 3 bar gauge and a hydrogen flow rate of 85 ml/min and a n-hexanal flow rate of 0.05 ml/min. After various times on-line, samples of the products were analysed by mass spectroscopy and gas chromatography.
- hexanol (moles of n-hexanol formed) ⁇ 100/(moles of n-hexanal fed)
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9825703.3 | 1998-11-25 | ||
GB9825703 | 1998-11-25 | ||
GBGB9825703.3A GB9825703D0 (en) | 1998-11-25 | 1998-11-25 | Aldol condensation |
GBGB9901324.5A GB9901324D0 (en) | 1999-01-22 | 1999-01-22 | Aldol condensation |
GB9901324 | 1999-01-22 | ||
PCT/GB1999/003534 WO2000031011A1 (en) | 1998-11-25 | 1999-10-25 | Aldol condensation |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1999/003534 Continuation WO2000031011A1 (en) | 1998-11-25 | 1999-10-25 | Aldol condensation |
Publications (2)
Publication Number | Publication Date |
---|---|
US20010044558A1 US20010044558A1 (en) | 2001-11-22 |
US6586636B2 true US6586636B2 (en) | 2003-07-01 |
Family
ID=26314720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/861,529 Expired - Fee Related US6586636B2 (en) | 1998-11-25 | 2001-05-22 | Aldol condensation |
Country Status (13)
Country | Link |
---|---|
US (1) | US6586636B2 (de) |
EP (1) | EP1133463B1 (de) |
JP (1) | JP2002530361A (de) |
KR (1) | KR20010080555A (de) |
CN (1) | CN1171841C (de) |
AT (1) | ATE285392T1 (de) |
AU (1) | AU6356999A (de) |
BR (1) | BR9915614A (de) |
CA (1) | CA2351475A1 (de) |
DE (1) | DE69922836D1 (de) |
ID (1) | ID28690A (de) |
PL (1) | PL348632A1 (de) |
WO (1) | WO2000031011A1 (de) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050151278A1 (en) * | 2003-11-24 | 2005-07-14 | Michael Lefenfeld | Silica gel compositions containing alkali metals and alkali metal alloy |
US20060002839A1 (en) * | 2004-06-14 | 2006-01-05 | Michael Lefenfeld | Silicide compositions containing alkali metals and methods of making the same |
US20060073968A1 (en) * | 2004-09-22 | 2006-04-06 | Signa Chemistry Llc | Titanium oxide and alumina alkali metal compositions |
US20060149101A1 (en) * | 2004-12-30 | 2006-07-06 | Council Of Scientific And Industrial Research | Process for preparing aldol derivatives from alkenes using catalyst |
US20090012274A1 (en) * | 2007-07-06 | 2009-01-08 | Stephane Biltresse | Unsaturated aldehyde surfaces and methods of molecular immobilization |
US20090112026A1 (en) * | 2007-10-29 | 2009-04-30 | Carter Technologies | Formation of hydroxycarbonyl compounds |
US20100234644A1 (en) * | 2009-03-10 | 2010-09-16 | Carter Technologies | Formation of hydroxycarbonl compounds |
US20100247426A1 (en) * | 2009-03-30 | 2010-09-30 | Signa Chemistry, Inc. | Hydrogen generation systems utilizing sodium silicide and sodium silica gel materials |
CN101214438B (zh) * | 2007-12-27 | 2010-10-13 | 郑州大学 | 羟醛缩合催化剂及其应用 |
US8632928B2 (en) | 2010-11-08 | 2014-01-21 | Signa Chemistry, Inc. | Water reactive hydrogen fuel cell power system |
US8895204B2 (en) | 2010-11-08 | 2014-11-25 | Intelligent Energy Limited | Water reactive hydrogen fuel cell power system |
US9102528B2 (en) | 2009-03-30 | 2015-08-11 | Intelligent Energy Limited | Hydrogen generation systems and methods utilizing sodium silicide and sodium silica gel materials |
US9492813B2 (en) * | 2012-05-25 | 2016-11-15 | Lg Chem, Ltd. | Method for regenerating hydrogenation catalyst |
RU2649577C1 (ru) * | 2017-05-26 | 2018-04-04 | Ирина Игоревна Иванова | Способ получения 2-этилгексеналя |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10248002A1 (de) * | 2002-10-15 | 2004-04-29 | Basf Ag | Verfahren zur Herstellung von Alkylarylsulfonaten |
US7649112B2 (en) * | 2005-07-25 | 2010-01-19 | Saudi Basic Industries Corporation | Integrated plant for producing 2-ethyl-hexanol and methacrylic acid and a method based thereon |
CN102188967B (zh) * | 2011-03-24 | 2012-08-15 | 宁波千衍新材料科技有限公司 | 一种羟醛缩合催化剂及其制备方法和用途 |
CN104174341B (zh) * | 2013-05-27 | 2017-09-26 | 乌鲁木齐益好天成新型节能材料有限公司 | 一种固相硅凝胶的制备方法 |
US9822053B2 (en) | 2016-01-28 | 2017-11-21 | Eastman Chemical Company | Single step conversion of N-butyraldehyde to 2-ethylhexanal |
CN113087605B (zh) * | 2019-12-23 | 2023-05-26 | 内蒙古伊泰煤基新材料研究院有限公司 | 一种制备辛烯醛的方法 |
WO2024089252A1 (en) | 2022-10-28 | 2024-05-02 | Basf Se | Process for the manufacture of a propylene-derived chemical of interest, in particular an acrylic ester, from renewably-sourced ethanol |
Citations (6)
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FR870204A (fr) | 1939-03-14 | 1942-03-05 | Degussa | Procédé pour préparer des cétones non saturées présentant un groupe vinyle extrême |
GB731917A (en) | 1951-05-03 | 1955-06-15 | Arthur Jack Sackville Evans | Manufacture of 2-ethyl-hexanal-(1) and 2-ethyl-hexanol-(1) |
GB1458129A (en) | 1974-02-12 | 1976-12-08 | Shell Int Research | Process for the preparation of beta-hydroxy-carbonyl compounds |
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-
1999
- 1999-10-25 BR BR9915614-8A patent/BR9915614A/pt not_active IP Right Cessation
- 1999-10-25 AU AU63569/99A patent/AU6356999A/en not_active Abandoned
- 1999-10-25 CN CNB99813760XA patent/CN1171841C/zh not_active Expired - Fee Related
- 1999-10-25 WO PCT/GB1999/003534 patent/WO2000031011A1/en active IP Right Grant
- 1999-10-25 EP EP99950986A patent/EP1133463B1/de not_active Expired - Lifetime
- 1999-10-25 CA CA002351475A patent/CA2351475A1/en not_active Abandoned
- 1999-10-25 KR KR1020017006502A patent/KR20010080555A/ko active IP Right Grant
- 1999-10-25 AT AT99950986T patent/ATE285392T1/de not_active IP Right Cessation
- 1999-10-25 PL PL99348632A patent/PL348632A1/xx unknown
- 1999-10-25 ID IDW00200101117A patent/ID28690A/id unknown
- 1999-10-25 DE DE69922836T patent/DE69922836D1/de not_active Expired - Lifetime
- 1999-10-25 JP JP2000583840A patent/JP2002530361A/ja active Pending
-
2001
- 2001-05-22 US US09/861,529 patent/US6586636B2/en not_active Expired - Fee Related
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US5334770A (en) * | 1992-07-09 | 1994-08-02 | Sumitomo Chemical Company, Limited | Process of aldol condensation by gas-phase reaction |
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Cited By (35)
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US7410567B2 (en) | 2003-11-24 | 2008-08-12 | Signa Chemistry, Llc | Silica gel compositions containing alkali metals and alkali metal alloys |
US20050151278A1 (en) * | 2003-11-24 | 2005-07-14 | Michael Lefenfeld | Silica gel compositions containing alkali metals and alkali metal alloy |
US20100166648A1 (en) * | 2003-11-24 | 2010-07-01 | Signa Chemistry, Inc. | Silica gel compositions containing alkali metals and alkali metal alloys |
US8501036B2 (en) | 2003-11-24 | 2013-08-06 | Signa Chemistry, Inc. | Silica gel compositions containing alkali metals and alkali metal alloys |
US7211539B2 (en) | 2003-11-24 | 2007-05-01 | Signa Chemistry, Llc | Silica gel compositions containing alkali metals and alkali metal alloys |
US20070167317A1 (en) * | 2003-11-24 | 2007-07-19 | Signa Chemistry, Llc | Silica gel compositions containing alkali metals and alkali metal alloys |
US20090041614A1 (en) * | 2003-11-24 | 2009-02-12 | Michael Lefenfeld | Silica gel compositions containing alkali metals and alkali metal alloys |
US8007762B2 (en) | 2003-11-24 | 2011-08-30 | Signa Chemistry, Inc. | Silica gel compositions containing alkali metals and alkali metal alloys |
US7709410B2 (en) | 2003-11-24 | 2010-05-04 | Signa Chemistry, Inc. | Silica gel compositions containing alkali metals and alkali metal alloys |
US20100316917A1 (en) * | 2004-06-14 | 2010-12-16 | Signa Chemistry, Inc. | Silicide compositions containing alkali metals and methods of making the same |
US8372371B2 (en) | 2004-06-14 | 2013-02-12 | Signa Chemistry, Inc. | Silicide compositions containing alkali metals and methods of making the same |
US20060002839A1 (en) * | 2004-06-14 | 2006-01-05 | Michael Lefenfeld | Silicide compositions containing alkali metals and methods of making the same |
US7811541B2 (en) | 2004-06-14 | 2010-10-12 | Signa Chemistry, Inc. | Silicide compositions containing alkali metals and methods of making the same |
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Also Published As
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PL348632A1 (en) | 2002-06-03 |
WO2000031011A1 (en) | 2000-06-02 |
AU6356999A (en) | 2000-06-13 |
JP2002530361A (ja) | 2002-09-17 |
DE69922836D1 (en) | 2005-01-27 |
EP1133463A1 (de) | 2001-09-19 |
CN1171841C (zh) | 2004-10-20 |
CN1328535A (zh) | 2001-12-26 |
ID28690A (id) | 2001-06-28 |
US20010044558A1 (en) | 2001-11-22 |
BR9915614A (pt) | 2001-08-14 |
ATE285392T1 (de) | 2005-01-15 |
CA2351475A1 (en) | 2000-06-02 |
KR20010080555A (ko) | 2001-08-22 |
EP1133463B1 (de) | 2004-12-22 |
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