US3826364B1 - - Google Patents

Download PDF

Info

Publication number
US3826364B1
US3826364B1 US25544372A US3826364B1 US 3826364 B1 US3826364 B1 US 3826364B1 US 25544372 A US25544372 A US 25544372A US 3826364 B1 US3826364 B1 US 3826364B1
Authority
US
United States
Prior art keywords
cells
drops
nozzle
stream
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to US00255443A priority Critical patent/US3826364A/en
Priority to DE2246380A priority patent/DE2246380C2/de
Priority to CA152,527A priority patent/CA974193A/en
Priority to JP48044234A priority patent/JPS49109093A/ja
Publication of US3826364A publication Critical patent/US3826364A/en
Application granted granted Critical
Publication of US3826364B1 publication Critical patent/US3826364B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
    • B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
    • B07C5/34—Sorting according to other particular properties
    • B07C5/342—Sorting according to other particular properties according to optical properties, e.g. colour
    • B07C5/3425—Sorting according to other particular properties according to optical properties, e.g. colour of granular material, e.g. ore particles, grain
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
    • B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
    • B07C5/36—Sorting apparatus characterised by the means used for distribution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1406—Control of droplet point

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
US00255443A 1972-05-22 1972-05-22 Particle sorting method and apparatus Expired - Lifetime US3826364A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US00255443A US3826364A (en) 1972-05-22 1972-05-22 Particle sorting method and apparatus
DE2246380A DE2246380C2 (de) 1972-05-22 1972-09-21 Vorrichtung zum Trennen bzw. Sortieren von Teilchen
CA152,527A CA974193A (en) 1972-05-22 1972-09-26 Chopped stream fluidized particle sensor charger and deflector
JP48044234A JPS49109093A (no) 1972-05-22 1973-04-20

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00255443A US3826364A (en) 1972-05-22 1972-05-22 Particle sorting method and apparatus

Publications (2)

Publication Number Publication Date
US3826364A US3826364A (en) 1974-07-30
US3826364B1 true US3826364B1 (no) 1984-09-25

Family

ID=22968350

Family Applications (1)

Application Number Title Priority Date Filing Date
US00255443A Expired - Lifetime US3826364A (en) 1972-05-22 1972-05-22 Particle sorting method and apparatus

Country Status (4)

Country Link
US (1) US3826364A (no)
JP (1) JPS49109093A (no)
CA (1) CA974193A (no)
DE (1) DE2246380C2 (no)

Cited By (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963606A (en) * 1974-06-03 1976-06-15 Coulter Electronics, Inc. Semi-automatic adjusting delay for an electronic particle separator
US3976197A (en) * 1974-11-22 1976-08-24 Bhattacharya Bhairab C Thermal convection counter streaming sedimentation method and apparatus for controlling the sex of mammalian offspring
US4097373A (en) * 1977-03-23 1978-06-27 John Caldwell Allred High speed particle sorter using a field emission electrode
FR2397634A1 (fr) * 1977-07-16 1979-02-09 Deutsches Krebsforsch Procede et dispositif d'analyse de la fluorescence de particules colorees, en particulier de cellules biologiques
US4148718A (en) * 1976-06-10 1979-04-10 Coulter Electronics, Inc. Single drop separator
US4175662A (en) * 1977-04-12 1979-11-27 Tibor Zold Method and device for sorting particles suspended in an electrolyte
US4230558A (en) * 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4279345A (en) * 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
US4317520A (en) * 1979-08-20 1982-03-02 Ortho Diagnostics, Inc. Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus
US4318482A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system
US4318481A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter
US4318480A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device
US4318483A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system
US4325483A (en) * 1979-08-20 1982-04-20 Ortho Diagnostics, Inc. Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus
US4347935A (en) * 1979-05-16 1982-09-07 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for electrostatically sorting biological cells
US4367043A (en) * 1980-05-05 1983-01-04 Leland Stanford Junior University Method and means for delivering liquid samples to a sample scanning device
US4395397A (en) * 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
FR2543298A1 (fr) * 1983-03-24 1984-09-28 Coulter Corp Dispositif d'analyse et de triage de particules
US4487320A (en) * 1980-11-03 1984-12-11 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4498766A (en) * 1982-03-25 1985-02-12 Becton, Dickinson And Company Light beam focal spot elongation in flow cytometry devices
US4499052A (en) * 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
FR2557977A1 (fr) * 1984-01-06 1985-07-12 Us Energy Appareil pour eliminer une interference de bruit de fond dans des mesures de fluorescence
US4538733A (en) * 1983-10-14 1985-09-03 Becton, Dickinson And Company Particle sorter with neutralized collection wells and method of using same
US4545677A (en) * 1984-03-05 1985-10-08 Becton, Dickinson And Company Prismatic beam expander for light beam shaping in a flow cytometry apparatus
US4599307A (en) * 1983-07-18 1986-07-08 Becton, Dickinson And Company Method for elimination of selected cell populations in analytic cytology
EP0210343A1 (en) * 1985-07-29 1987-02-04 Becton, Dickinson and Company Flow cytometry apparatus with improved light beam adjustment
US4663522A (en) * 1984-10-05 1987-05-05 Spandrel Establishment Integrating sphere device for measuring transmission of light in objects
US4667830A (en) * 1981-06-15 1987-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and means for sorting individual particles into containers for culturing, cloning, analysis, or the like
US4691829A (en) * 1980-11-03 1987-09-08 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4701664A (en) * 1986-01-09 1987-10-20 Becton, Dickinson And Company Mercury arc lamp suitable for inclusion in a flow cytometry apparatus
US4710635A (en) * 1986-04-14 1987-12-01 Becton, Dickinson And Company Dual laser excitation from single laser source
US4745285A (en) * 1986-08-21 1988-05-17 Becton Dickinson And Company Multi-color fluorescence analysis with single wavelength excitation
US4781459A (en) * 1985-05-17 1988-11-01 Horiba, Ltd. Apparatus for measuring the amount of minute particles contained in liquid
WO1989000894A1 (en) * 1987-08-05 1989-02-09 The Board Of Trustees Of The Leland Stanford Junio Apparatus and method for multidimensional characterization of objects in real time
WO1990013368A1 (en) * 1989-05-01 1990-11-15 Coulter Corporation Coincidence arbitration in a flow cytometry sorting system
US5047321A (en) * 1988-06-15 1991-09-10 Becton Dickinson & Co. Method for analysis of cellular components of a fluid
US5057413A (en) * 1988-06-13 1991-10-15 Becton, Dickinson And Company Method for discriminating between intact and damaged cells in a sample
US5064616A (en) * 1987-11-30 1991-11-12 Becton Dickinson And Company Kit for analysis of subsets of subpopulations of leukocytes
EP0455867A2 (en) * 1990-05-07 1991-11-13 Esm International, Inc. Sorting machine incorporating photo site processing
EP0461618A2 (en) * 1990-06-13 1991-12-18 Becton, Dickinson and Company Cleaning cycle for flow cytometers
US5076472A (en) * 1990-06-13 1991-12-31 Becton, Dickinson And Company Cleaning cycle for flow cytometers
US5089384A (en) * 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
US5098849A (en) * 1988-07-13 1992-03-24 Becton Dickinson And Company Material and method to reduce non-specific binding of a labelled material
US5108904A (en) * 1990-03-26 1992-04-28 Alan Landay CD44 as a marker for HIV infection
US5123731A (en) * 1988-02-01 1992-06-23 Canon Kabushiki Kaisha Particle measuring device
US5156951A (en) * 1989-07-13 1992-10-20 Becton Dickinson And Company Detecting immunological changes in HIV infected patient samples
US5180065A (en) * 1989-10-11 1993-01-19 Canon Kabushiki Kaisha Apparatus for and method of fractionating particle in particle-suspended liquid in conformity with the properties thereof
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
US5224058A (en) * 1990-05-01 1993-06-29 Becton, Dickinson And Company Method for data transformation
US5232828A (en) * 1992-03-09 1993-08-03 Becton, Dickinson And Company Coating agents for cell recovery
EP0553951A1 (en) * 1992-01-30 1993-08-04 Toa Medical Electronics Company, Limited Particle judging device
US5247340A (en) * 1991-02-27 1993-09-21 Toa Medical Electronics Co., Ltd. Flow imaging cytometer
US5247339A (en) * 1991-02-27 1993-09-21 Toa Medical Electronics Co., Ltd. Flow imaging cytometer
US5275787A (en) * 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
WO1996012171A2 (en) * 1994-10-14 1996-04-25 University Of Washington High speed flow cytometer droplet formation system
EP0711991A1 (en) * 1994-11-14 1996-05-15 TOA MEDICAL ELECTRONICS CO., Ltd. Particle analyzer
US5602039A (en) * 1994-10-14 1997-02-11 The University Of Washington Flow cytometer jet monitor system
US5689110A (en) * 1994-09-02 1997-11-18 Biometric Imaging, Inc. Calibration method and apparatus for optical scanner
US5700692A (en) * 1994-09-27 1997-12-23 Becton Dickinson And Company Flow sorter with video-regulated droplet spacing
WO1998006821A1 (en) * 1996-08-12 1998-02-19 Pressium Limited Dispensing of particles
US5726364A (en) * 1994-10-14 1998-03-10 The University Of Washington Sample introduction apparatus for a flow cytometer
US5915925A (en) * 1997-01-07 1999-06-29 North, Jr.; Howard L. Pulseless liquid supply system for flow cytometry
WO1999044037A1 (en) * 1998-02-27 1999-09-02 Cytomation, Inc. Method and apparatus for flow cytometry
US6079836A (en) * 1998-07-20 2000-06-27 Coulter International Corp. Flow cytometer droplet break-off location adjustment mechanism
US6281018B1 (en) 1998-02-26 2001-08-28 Coulter International Corp. Selective purification and enrichment sorting of flow cytometer droplets based upon analysis of droplet precursor regions
US6332540B1 (en) * 1997-04-08 2001-12-25 Smithkline Beecham P.L.C. Device for isolating small polymeric beads from a suspension of such beads
WO2002010714A2 (en) * 2000-08-02 2002-02-07 Honeywell International Inc. Optical detection system for flow cytometry
WO2002034886A2 (en) 2000-10-27 2002-05-02 Board Of Regents, The University Of Texas System Isolation of binding proteins with high affinity to ligands
WO2002072766A2 (en) 2001-03-09 2002-09-19 Board Of Regents, Universitx Of Texas System Induction of tumor immunity by variants of folate binding protein
US20030211009A1 (en) * 2001-05-18 2003-11-13 Buchanan Kris S. Rapid multi-material sample input system
US20040055030A1 (en) * 2002-09-13 2004-03-18 Xy, Inc. Sperm cell processing and preservation systems
US20040171163A1 (en) * 2000-12-15 2004-09-02 Lopez Peter A. Electrical conductive containment system
US6819411B1 (en) 1997-01-31 2004-11-16 Xy, Inc. Optical apparatus
US20050006596A1 (en) * 2003-07-09 2005-01-13 Aisin Seiki Kabushiki Kaisha Light irradiating apparatus for cell sorter
US6861265B1 (en) 1994-10-14 2005-03-01 University Of Washington Flow cytometer droplet formation system
WO2005033283A2 (en) * 2003-09-30 2005-04-14 Singulex, Inc. Methods for enhancing the analysis of particle detection
US20050227362A1 (en) * 2004-04-07 2005-10-13 Beckman Coulter, Inc. Multiple sorter monitor and control subsystem for flow cytometer
US7012689B2 (en) 2001-05-17 2006-03-14 Dako Colorado, Inc. Flow cytometer with active automated optical alignment system
US7024316B1 (en) 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US20060180517A1 (en) * 2005-01-12 2006-08-17 Beckman Coulter, Inc. Methods and apparatus for sorting particles hydraulically
US7094527B2 (en) 2000-11-29 2006-08-22 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into X-chromosome and Y-chromosome bearing populations
US20070013910A1 (en) * 2004-07-30 2007-01-18 Jian-Ping Jiang Pathogen and particle detector system and method
EP1332353A4 (en) * 2000-10-11 2007-01-24 Best N V APPARATUS AND METHOD FOR SCANNING PRODUCTS USING A LIGHT BEAM TO DETECT AND REMOVE IMPURITIES OR IRREGULARITIES IN A TRANSPORT PRODUCT STREAM
EP1754964A2 (en) * 2003-08-13 2007-02-21 Luminex Corporation Methods for controlling one or more parameters of a flow cytometer type measurement system
US7195920B2 (en) 1997-12-31 2007-03-27 Xy, Inc. Collection systems for cytometer sorting of sperm
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US20070195310A1 (en) * 2004-04-30 2007-08-23 Masahiko Kanda System And Process For Sorting Biological Particles
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
US7371517B2 (en) 2000-05-09 2008-05-13 Xy, Inc. High purity X-chromosome bearing and Y-chromosome bearing populations of spermatozoa
US20080248562A1 (en) * 2004-01-23 2008-10-09 Tadashi Sano Microorganism Separation Device
WO2008137475A2 (en) 2007-05-01 2008-11-13 Research Development Foundation Immunoglobulin fc libraries
EP2053380A2 (en) 2007-10-26 2009-04-29 Becton, Dickinson and Company, Wagner, Jaconda Deflection Plate
US20090242799A1 (en) * 2007-12-03 2009-10-01 Bolotin Charles E Method for the detection of biologic particle contamination
US7618770B2 (en) 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
US20090287421A1 (en) * 2004-07-27 2009-11-19 George C Malachowski Enhancing Flow Cytometry Discrimination with Geometric Transformation
US7629113B2 (en) 1997-12-31 2009-12-08 Xy, Inc Multiple sexed embryo production system for bovine mammals
WO2010022019A1 (en) 2008-08-21 2010-02-25 Siemens Healthcare Diagnostics Inc. Multi-layer slides for analysis of urine sediments
US20100065734A1 (en) * 2006-12-04 2010-03-18 The University Of Queensland Particle sorting apparatus and method
US20100108910A1 (en) * 2005-07-15 2010-05-06 Michael Morrell Pathogen and particle detector system and method
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US7723116B2 (en) 2003-05-15 2010-05-25 Xy, Inc. Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm
US7758811B2 (en) 2003-03-28 2010-07-20 Inguran, Llc System for analyzing particles using multiple flow cytometry units
US7772005B1 (en) 1998-07-30 2010-08-10 Xy, Llc Method of establishing an equine artificial insemination sample
WO2010090279A1 (ja) 2009-02-06 2010-08-12 株式会社オンチップ・バイオテクノロジーズ 使い捨てチップ型フローセルとそれを用いたフローサイトメーター
US7833147B2 (en) 2004-07-22 2010-11-16 Inguran, LLC. Process for enriching a population of sperm cells
US7838210B2 (en) 2004-03-29 2010-11-23 Inguran, LLC. Sperm suspensions for sorting into X or Y chromosome-bearing enriched populations
US7855078B2 (en) 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
WO2011086990A1 (ja) 2010-01-15 2011-07-21 株式会社オンチップ・バイオテクノロジーズ 使い捨てチップ型フローセルとそれを用いたセルソーター
US8211629B2 (en) 2002-08-01 2012-07-03 Xy, Llc Low pressure sperm cell separation system
WO2012109133A1 (en) 2011-02-07 2012-08-16 Research Development Foundation Engineered immunoglobulin fc polypeptides
WO2013039883A1 (en) 2011-09-12 2013-03-21 Abbvie Biotherapeutics Inc. Artificial nk cells and uses thereof
DE102011054659A1 (de) * 2011-10-20 2013-04-25 AeroMegt GmbH Verfahren und Vorrichtung zum Messen von Aerosolen in einem großen Volumenstrom
CN103180713A (zh) * 2011-08-25 2013-06-26 索尼公司 移动微实体流中的运动相关误差的表征
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
TWI403454B (zh) * 2006-08-11 2013-08-01 Sokudo Co Ltd 用於監視與控制光阻分散系統之倒吸量的設備及方法
WO2013116698A2 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
US20130229655A1 (en) * 2010-10-26 2013-09-05 University Of Hertfordshire Higher Education Corporation Second Generation Low-Cost Particle Counter
US8582100B1 (en) * 2012-06-19 2013-11-12 The United States Of America, As Represented By The Secretary Of The Navy Remote multisensor optical particle monitor for flowing fluid systems
WO2013188770A1 (en) * 2012-06-14 2013-12-19 Bio-Rad Laboratories, Inc. Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry
US8654329B2 (en) * 2012-06-19 2014-02-18 The United States Of America, As Represented By The Secretary Of The Navy Parallel multisensor optical particle sensors for flowing fluid systems
US20140220557A1 (en) * 2007-12-21 2014-08-07 Sean J. Hart Device and Method for Laser Analysis and Separation (LAS) of Particles
US8830451B1 (en) * 2010-05-07 2014-09-09 Stc.Unm Multinode acoustic focusing for parallel flow cytometry analysis applications
US20150131099A1 (en) * 2013-11-14 2015-05-14 Sony Corporation Light irradiation device, particle analysis device, and light irradiation method
US9074977B2 (en) 2010-05-07 2015-07-07 Stc.Unm Multinode acoustic focusing for parallel flow cytometry analysis applications
EP2917718A1 (en) * 2012-11-08 2015-09-16 Sony Corporation Microparticle fractionating apparatus and method of fractionating microparticle
WO2016061199A2 (en) 2014-10-14 2016-04-21 Research Development Foundation Methods for generating engineered enzymes
WO2016130516A1 (en) 2015-02-09 2016-08-18 Research Development Foundation Engineered immunoglobulin fc polypeptides displaying improved complement activation
US20170052116A1 (en) * 2014-02-19 2017-02-23 Arizona Board Of Regents On Behalf Of Arizona State University System and method for isotopic analysis of calcium using laser induced fluorescence
WO2017040380A2 (en) 2015-08-28 2017-03-09 Research Development Foundation Engineered antibody fc variants
US9592483B2 (en) 2012-06-07 2017-03-14 Bio-Rad Laboratories, Inc. Fluid mixing and rinsing system for a flow cytometer
US9913887B2 (en) 2011-04-29 2018-03-13 Baylor College Of Medicine Ureaplasma vaccine and antibodies
WO2018052137A1 (ja) 2016-09-16 2018-03-22 株式会社オンチップ・バイオテクノロジーズ 微粒子分注装置、微粒子解析装置、及び反応検出装置、並びにそれらを用いる方法
US10132735B2 (en) 2012-03-30 2018-11-20 Sony Corporation Microparticle sorting device and method of optimizing fluid stream therein
US20190011350A1 (en) * 2015-12-23 2019-01-10 Siemens Healthcare Gmbh Flow cell for analyzing particles in a liquid to be examined
US20190025185A1 (en) * 2017-07-21 2019-01-24 Ikuo Katoh Particle counting apparatus, particle counting method, and particle containing sample
US10241025B2 (en) 2013-01-28 2019-03-26 Sony Corporation Microparticle sorting device, and method and program for sorting microparticles
US10309891B2 (en) 2013-10-16 2019-06-04 Sony Corporation Particle sorting apparatus, particle sorting method, and program
US10309892B2 (en) 2014-02-13 2019-06-04 Sony Corporation Particle sorting device, particle sorting method, program, and particle sorting system
US20190212256A1 (en) * 2016-09-13 2019-07-11 Basf Coatings Gmbh Sensor for a virtually simultaneous measurement of a transmission and/or forward scattering and/or remission and for a simultaneous measurement of the transmission and forward scattering or transmission and remission of a liquid sample
US10386287B2 (en) 2014-09-05 2019-08-20 Sony Corporation Droplet sorting device, droplet sorting method and program
DE102018210015A1 (de) * 2018-06-20 2019-12-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zur Sortierung von pulverförmigem oder stückförmigem Material
US10605714B2 (en) 2015-10-19 2020-03-31 Sony Corporation Image processing device, fine particle sorting device, and image processing method
US10723497B2 (en) * 2014-11-03 2020-07-28 Vanrx Pharmasystems Inc. Apparatus and method for monitoring and controlling the filling of a container with a pharmaceutical fluid in an aseptic environment
US10780706B2 (en) * 2018-03-16 2020-09-22 Ricoh Company, Ltd. Discharging device and discharging method
US11035776B2 (en) * 2018-10-30 2021-06-15 Becton, Dickinson And Company Particle sorting module with alignment window, systems and methods of use thereof
WO2021178637A1 (en) 2020-03-05 2021-09-10 Iowa State University Research Foundation, Inc. IMMUNOGENIC AND VACCINE COMPOSITIONS AGAINST SARS-CoV-2
US11193874B2 (en) 2012-03-30 2021-12-07 Sony Corporation Micro-particle sorting apparatus and method of determining a trajectory of an ejected stream carrying micro-particles
US11287364B2 (en) * 2018-07-10 2022-03-29 Gerrit Jan van den Engh System, apparatus and method for off-axis illumination in flow cytometry
RU218768U1 (ru) * 2022-12-27 2023-06-09 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Устройство для анализа содержания аэрозолей и паров углеводородов в атмосфере
US11725179B2 (en) 2015-05-12 2023-08-15 On-Chip Biotechnologies Co., Ltd. Single-particle analysis method, and system for performing said analysis
WO2023239940A1 (en) 2022-06-10 2023-12-14 Research Development Foundation Engineered fcriib selective igg1 fc variants and uses thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0177718B1 (de) * 1984-09-11 1989-12-06 Partec AG Verfahren und Vorrichtung zur Sortierung von mikroskopischen Partikeln
JPS62126326A (ja) * 1985-11-26 1987-06-08 Rion Co Ltd 粒子計測方法
DE102019215692B4 (de) * 2019-10-11 2021-06-17 Gunther Krieg Vorrichtung und Verfahren zur Identifikation von Stoffen in der Fluidzusammensetzung
WO2022209859A1 (ja) * 2021-03-30 2022-10-06 ソニーグループ株式会社 粒子分析装置及び粒子分析方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2948470A (en) * 1957-03-15 1960-08-09 Du Mont Allen B Lab Inc Particle counter
US3011634A (en) * 1958-03-03 1961-12-05 K & H Equipment Ltd Method and apparatus for sorting materials
US3380584A (en) * 1965-06-04 1968-04-30 Atomic Energy Commission Usa Particle separator
US3675768A (en) * 1969-03-17 1972-07-11 Gildardo Legorreta Sanchez Method and apparatus for classifying and segregating particles with electrical and optical means
US3669542A (en) * 1969-10-09 1972-06-13 Coulter Electronics Liquid borne particle sensor
US3661460A (en) * 1970-08-28 1972-05-09 Technicon Instr Method and apparatus for optical analysis of the contents of a sheathed stream
BE793185A (fr) * 1971-12-23 1973-04-16 Atomic Energy Commission Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques

Cited By (254)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963606A (en) * 1974-06-03 1976-06-15 Coulter Electronics, Inc. Semi-automatic adjusting delay for an electronic particle separator
US3976197A (en) * 1974-11-22 1976-08-24 Bhattacharya Bhairab C Thermal convection counter streaming sedimentation method and apparatus for controlling the sex of mammalian offspring
US4148718A (en) * 1976-06-10 1979-04-10 Coulter Electronics, Inc. Single drop separator
US4097373A (en) * 1977-03-23 1978-06-27 John Caldwell Allred High speed particle sorter using a field emission electrode
US4175662A (en) * 1977-04-12 1979-11-27 Tibor Zold Method and device for sorting particles suspended in an electrolyte
FR2397634A1 (fr) * 1977-07-16 1979-02-09 Deutsches Krebsforsch Procede et dispositif d'analyse de la fluorescence de particules colorees, en particulier de cellules biologiques
US4230558A (en) * 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4347935A (en) * 1979-05-16 1982-09-07 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for electrostatically sorting biological cells
US4279345A (en) * 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
US4318483A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system
US4317520A (en) * 1979-08-20 1982-03-02 Ortho Diagnostics, Inc. Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus
US4318480A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device
US4325483A (en) * 1979-08-20 1982-04-20 Ortho Diagnostics, Inc. Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus
US4318482A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system
US4318481A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter
US4367043A (en) * 1980-05-05 1983-01-04 Leland Stanford Junior University Method and means for delivering liquid samples to a sample scanning device
US4691829A (en) * 1980-11-03 1987-09-08 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4487320A (en) * 1980-11-03 1984-12-11 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4667830A (en) * 1981-06-15 1987-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and means for sorting individual particles into containers for culturing, cloning, analysis, or the like
US4395397A (en) * 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
US4498766A (en) * 1982-03-25 1985-02-12 Becton, Dickinson And Company Light beam focal spot elongation in flow cytometry devices
US4499052A (en) * 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
FR2543298A1 (fr) * 1983-03-24 1984-09-28 Coulter Corp Dispositif d'analyse et de triage de particules
US4599307A (en) * 1983-07-18 1986-07-08 Becton, Dickinson And Company Method for elimination of selected cell populations in analytic cytology
US4538733A (en) * 1983-10-14 1985-09-03 Becton, Dickinson And Company Particle sorter with neutralized collection wells and method of using same
FR2557977A1 (fr) * 1984-01-06 1985-07-12 Us Energy Appareil pour eliminer une interference de bruit de fond dans des mesures de fluorescence
US4573796A (en) * 1984-01-06 1986-03-04 The United States Of America As Represented By The United States Department Of Energy Apparatus for eliminating background interference in fluorescence measurements
US4545677A (en) * 1984-03-05 1985-10-08 Becton, Dickinson And Company Prismatic beam expander for light beam shaping in a flow cytometry apparatus
US4663522A (en) * 1984-10-05 1987-05-05 Spandrel Establishment Integrating sphere device for measuring transmission of light in objects
AU584923B2 (en) * 1984-10-05 1989-06-08 Spandrel Establishment Producing a signal responsive to a parameter of objects
US4781459A (en) * 1985-05-17 1988-11-01 Horiba, Ltd. Apparatus for measuring the amount of minute particles contained in liquid
EP0210343A1 (en) * 1985-07-29 1987-02-04 Becton, Dickinson and Company Flow cytometry apparatus with improved light beam adjustment
US4989977A (en) * 1985-07-29 1991-02-05 Becton, Dickinson And Company Flow cytometry apparatus with improved light beam adjustment
US4701664A (en) * 1986-01-09 1987-10-20 Becton, Dickinson And Company Mercury arc lamp suitable for inclusion in a flow cytometry apparatus
US4710635A (en) * 1986-04-14 1987-12-01 Becton, Dickinson And Company Dual laser excitation from single laser source
US4745285A (en) * 1986-08-21 1988-05-17 Becton Dickinson And Company Multi-color fluorescence analysis with single wavelength excitation
WO1989000894A1 (en) * 1987-08-05 1989-02-09 The Board Of Trustees Of The Leland Stanford Junio Apparatus and method for multidimensional characterization of objects in real time
US4987539A (en) * 1987-08-05 1991-01-22 Stanford University Apparatus and method for multidimensional characterization of objects in real time
US5064616A (en) * 1987-11-30 1991-11-12 Becton Dickinson And Company Kit for analysis of subsets of subpopulations of leukocytes
US5123731A (en) * 1988-02-01 1992-06-23 Canon Kabushiki Kaisha Particle measuring device
US5057413A (en) * 1988-06-13 1991-10-15 Becton, Dickinson And Company Method for discriminating between intact and damaged cells in a sample
US5047321A (en) * 1988-06-15 1991-09-10 Becton Dickinson & Co. Method for analysis of cellular components of a fluid
US5098849A (en) * 1988-07-13 1992-03-24 Becton Dickinson And Company Material and method to reduce non-specific binding of a labelled material
US5089384A (en) * 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
WO1990013368A1 (en) * 1989-05-01 1990-11-15 Coulter Corporation Coincidence arbitration in a flow cytometry sorting system
US4981580A (en) * 1989-05-01 1991-01-01 Coulter Corporation Coincidence arbitration in a flow cytomery sorting system
US5156951A (en) * 1989-07-13 1992-10-20 Becton Dickinson And Company Detecting immunological changes in HIV infected patient samples
US5275787A (en) * 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
US5180065A (en) * 1989-10-11 1993-01-19 Canon Kabushiki Kaisha Apparatus for and method of fractionating particle in particle-suspended liquid in conformity with the properties thereof
US5108904A (en) * 1990-03-26 1992-04-28 Alan Landay CD44 as a marker for HIV infection
US5224058A (en) * 1990-05-01 1993-06-29 Becton, Dickinson And Company Method for data transformation
EP0630692A3 (en) * 1990-05-07 1997-05-14 Esm Int Inc Sorting machine with background and photodetector standardization circuit.
EP0630693A2 (en) * 1990-05-07 1994-12-28 Esm International, Inc. A sorting machine including a defect size determiner
EP0455867A3 (en) * 1990-05-07 1992-04-15 Esm International, Inc. Sorting machine incorporating photo site processing
EP0455867A2 (en) * 1990-05-07 1991-11-13 Esm International, Inc. Sorting machine incorporating photo site processing
EP0630693A3 (en) * 1990-05-07 1997-05-14 Esm Int Inc Sorting machine including a defective format detector.
EP0630692A2 (en) * 1990-05-07 1994-12-28 Esm International, Inc. A sorting machine having background and photo-detector normalizer circuit
US5087295A (en) * 1990-06-13 1992-02-11 Becton Dickinson And Company Cleaning cycle for flow cytometers
EP0461618A3 (en) * 1990-06-13 1992-11-25 Becton Dickinson And Company Cleaning cycle for flow cytometers
EP0461618A2 (en) * 1990-06-13 1991-12-18 Becton, Dickinson and Company Cleaning cycle for flow cytometers
US5076472A (en) * 1990-06-13 1991-12-31 Becton, Dickinson And Company Cleaning cycle for flow cytometers
US5247340A (en) * 1991-02-27 1993-09-21 Toa Medical Electronics Co., Ltd. Flow imaging cytometer
US5247339A (en) * 1991-02-27 1993-09-21 Toa Medical Electronics Co., Ltd. Flow imaging cytometer
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
US5998212A (en) * 1991-04-05 1999-12-07 University Of Texas Medical Branch At Galveston Method for flexibly sorting particles
US5550058A (en) * 1991-04-05 1996-08-27 University Of Rochester System for flexibly sorting particles
EP0553951A1 (en) * 1992-01-30 1993-08-04 Toa Medical Electronics Company, Limited Particle judging device
US5232828A (en) * 1992-03-09 1993-08-03 Becton, Dickinson And Company Coating agents for cell recovery
US5689110A (en) * 1994-09-02 1997-11-18 Biometric Imaging, Inc. Calibration method and apparatus for optical scanner
US5700692A (en) * 1994-09-27 1997-12-23 Becton Dickinson And Company Flow sorter with video-regulated droplet spacing
US5602039A (en) * 1994-10-14 1997-02-11 The University Of Washington Flow cytometer jet monitor system
WO1996012171A2 (en) * 1994-10-14 1996-04-25 University Of Washington High speed flow cytometer droplet formation system
WO1996012171A3 (en) * 1994-10-14 1996-08-01 Univ Washington High speed flow cytometer droplet formation system
US5726364A (en) * 1994-10-14 1998-03-10 The University Of Washington Sample introduction apparatus for a flow cytometer
US7923252B2 (en) 1994-10-14 2011-04-12 University Of Washington Droplet formation systems for flow cytometers
US20050153458A1 (en) * 1994-10-14 2005-07-14 University Of Washington Droplet formation systems for flow cytometers
US6861265B1 (en) 1994-10-14 2005-03-01 University Of Washington Flow cytometer droplet formation system
US6133044A (en) * 1994-10-14 2000-10-17 University Of Washington High speed flow cytometer droplet formation system and method
US5719666A (en) * 1994-11-14 1998-02-17 Toa Medical Electronics Co., Ltd. Particle analyzer classifying particles of various biological types using a correlation of measurements
EP0711991A1 (en) * 1994-11-14 1996-05-15 TOA MEDICAL ELECTRONICS CO., Ltd. Particle analyzer
WO1998006821A1 (en) * 1996-08-12 1998-02-19 Pressium Limited Dispensing of particles
US5915925A (en) * 1997-01-07 1999-06-29 North, Jr.; Howard L. Pulseless liquid supply system for flow cytometry
US7929137B2 (en) 1997-01-31 2011-04-19 Xy, Llc Optical apparatus
US7221453B2 (en) 1997-01-31 2007-05-22 Xy, Inc. Optical apparatus
US7586604B2 (en) 1997-01-31 2009-09-08 Xy, Inc. Optical apparatus
US6819411B1 (en) 1997-01-31 2004-11-16 Xy, Inc. Optical apparatus
US6332540B1 (en) * 1997-04-08 2001-12-25 Smithkline Beecham P.L.C. Device for isolating small polymeric beads from a suspension of such beads
US7195920B2 (en) 1997-12-31 2007-03-27 Xy, Inc. Collection systems for cytometer sorting of sperm
US9365822B2 (en) 1997-12-31 2016-06-14 Xy, Llc System and method for sorting cells
US9422523B2 (en) 1997-12-31 2016-08-23 Xy, Llc System and method for sorting cells
US7629113B2 (en) 1997-12-31 2009-12-08 Xy, Inc Multiple sexed embryo production system for bovine mammals
US6281018B1 (en) 1998-02-26 2001-08-28 Coulter International Corp. Selective purification and enrichment sorting of flow cytometer droplets based upon analysis of droplet precursor regions
US6589792B1 (en) 1998-02-27 2003-07-08 Dakocytomation Denmark A/S Method and apparatus for flow cytometry
WO1999044037A1 (en) * 1998-02-27 1999-09-02 Cytomation, Inc. Method and apparatus for flow cytometry
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
US6079836A (en) * 1998-07-20 2000-06-27 Coulter International Corp. Flow cytometer droplet break-off location adjustment mechanism
US7772005B1 (en) 1998-07-30 2010-08-10 Xy, Llc Method of establishing an equine artificial insemination sample
US7024316B1 (en) 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US20060259253A1 (en) * 1999-10-21 2006-11-16 Dako Colorado, Inc. Systems for transiently dynamic flow cytometer analysis
US7820425B2 (en) 1999-11-24 2010-10-26 Xy, Llc Method of cryopreserving selected sperm cells
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US10208345B2 (en) 2000-05-09 2019-02-19 Xy, Llc Method for producing high purity X-chromosome bearing and Y-chromosome bearing populations of spermatozoa
US7371517B2 (en) 2000-05-09 2008-05-13 Xy, Inc. High purity X-chromosome bearing and Y-chromosome bearing populations of spermatozoa
US9145590B2 (en) 2000-05-09 2015-09-29 Xy, Llc Methods and apparatus for high purity X-chromosome bearing and Y-chromosome bearing populations of spermatozoa
WO2002010714A3 (en) * 2000-08-02 2003-01-30 Honeywell Int Inc Optical detection system for flow cytometry
WO2002010714A2 (en) * 2000-08-02 2002-02-07 Honeywell International Inc. Optical detection system for flow cytometry
EP1332353A4 (en) * 2000-10-11 2007-01-24 Best N V APPARATUS AND METHOD FOR SCANNING PRODUCTS USING A LIGHT BEAM TO DETECT AND REMOVE IMPURITIES OR IRREGULARITIES IN A TRANSPORT PRODUCT STREAM
WO2002034886A2 (en) 2000-10-27 2002-05-02 Board Of Regents, The University Of Texas System Isolation of binding proteins with high affinity to ligands
US8652769B2 (en) 2000-11-29 2014-02-18 Xy, Llc Methods for separating frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US7094527B2 (en) 2000-11-29 2006-08-22 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into X-chromosome and Y-chromosome bearing populations
US9879221B2 (en) 2000-11-29 2018-01-30 Xy, Llc Method of in-vitro fertilization with spermatozoa separated into X-chromosome and Y-chromosome bearing populations
US7771921B2 (en) 2000-11-29 2010-08-10 Xy, Llc Separation systems of frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations
US8137967B2 (en) 2000-11-29 2012-03-20 Xy, Llc In-vitro fertilization systems with spermatozoa separated into X-chromosome and Y-chromosome bearing populations
US20040171163A1 (en) * 2000-12-15 2004-09-02 Lopez Peter A. Electrical conductive containment system
WO2002072766A2 (en) 2001-03-09 2002-09-19 Board Of Regents, Universitx Of Texas System Induction of tumor immunity by variants of folate binding protein
US7012689B2 (en) 2001-05-17 2006-03-14 Dako Colorado, Inc. Flow cytometer with active automated optical alignment system
US20030211009A1 (en) * 2001-05-18 2003-11-13 Buchanan Kris S. Rapid multi-material sample input system
US8211629B2 (en) 2002-08-01 2012-07-03 Xy, Llc Low pressure sperm cell separation system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
US8497063B2 (en) 2002-08-01 2013-07-30 Xy, Llc Sex selected equine embryo production system
US7855078B2 (en) 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
US20040055030A1 (en) * 2002-09-13 2004-03-18 Xy, Inc. Sperm cell processing and preservation systems
US11230695B2 (en) 2002-09-13 2022-01-25 Xy, Llc Sperm cell processing and preservation systems
US11261424B2 (en) 2002-09-13 2022-03-01 Xy, Llc Sperm cell processing systems
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US11718826B2 (en) 2003-03-28 2023-08-08 Inguran, Llc System and method for sorting particles
US7799569B2 (en) 2003-03-28 2010-09-21 Inguran, Llc Process for evaluating staining conditions of cells for sorting
US9377390B2 (en) 2003-03-28 2016-06-28 Inguran, Llc Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm
US10100278B2 (en) 2003-03-28 2018-10-16 Inguran, Llc Multi-channel system and methods for sorting particles
US8664006B2 (en) 2003-03-28 2014-03-04 Inguran, Llc Flow cytometer apparatus and method
US7943384B2 (en) 2003-03-28 2011-05-17 Inguran Llc Apparatus and methods for sorting particles
US11104880B2 (en) 2003-03-28 2021-08-31 Inguran, Llc Photo-damage system for sorting particles
US8709817B2 (en) 2003-03-28 2014-04-29 Inguran, Llc Systems and methods for sorting particles
US8709825B2 (en) 2003-03-28 2014-04-29 Inguran, Llc Flow cytometer method and apparatus
US8748183B2 (en) 2003-03-28 2014-06-10 Inguran, Llc Method and apparatus for calibrating a flow cytometer
US7758811B2 (en) 2003-03-28 2010-07-20 Inguran, Llc System for analyzing particles using multiple flow cytometry units
US9040304B2 (en) 2003-03-28 2015-05-26 Inguran, Llc Multi-channel system and methods for sorting particles
US7723116B2 (en) 2003-05-15 2010-05-25 Xy, Inc. Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm
US20050006596A1 (en) * 2003-07-09 2005-01-13 Aisin Seiki Kabushiki Kaisha Light irradiating apparatus for cell sorter
EP1754964A2 (en) * 2003-08-13 2007-02-21 Luminex Corporation Methods for controlling one or more parameters of a flow cytometer type measurement system
WO2005033283A3 (en) * 2003-09-30 2005-08-04 Singulex Inc Methods for enhancing the analysis of particle detection
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
WO2005033283A2 (en) * 2003-09-30 2005-04-14 Singulex, Inc. Methods for enhancing the analysis of particle detection
US20080248562A1 (en) * 2004-01-23 2008-10-09 Tadashi Sano Microorganism Separation Device
US7892725B2 (en) 2004-03-29 2011-02-22 Inguran, Llc Process for storing a sperm dispersion
US7838210B2 (en) 2004-03-29 2010-11-23 Inguran, LLC. Sperm suspensions for sorting into X or Y chromosome-bearing enriched populations
US20050227362A1 (en) * 2004-04-07 2005-10-13 Beckman Coulter, Inc. Multiple sorter monitor and control subsystem for flow cytometer
WO2005100985A2 (en) * 2004-04-07 2005-10-27 Beckman Coulter, Inc. Multiple sorter monitor and control subsystem for flow cytometer
WO2005100985A3 (en) * 2004-04-07 2006-09-08 Beckman Coulter Inc Multiple sorter monitor and control subsystem for flow cytometer
US7232687B2 (en) * 2004-04-07 2007-06-19 Beckman Coulter, Inc. Multiple sorter monitor and control subsystem for flow cytometer
US7417734B2 (en) * 2004-04-30 2008-08-26 Bay Bioscience Kabushiki Kaisha System and process for sorting biological particles
US7639358B2 (en) * 2004-04-30 2009-12-29 Bay Bioscience Kabushiki Kaisha System and process for sorting biological particles
US20080304062A1 (en) * 2004-04-30 2008-12-11 Masahiko Kanda System and process for sorting biological particles
US20070195310A1 (en) * 2004-04-30 2007-08-23 Masahiko Kanda System And Process For Sorting Biological Particles
US7833147B2 (en) 2004-07-22 2010-11-16 Inguran, LLC. Process for enriching a population of sperm cells
US11408813B2 (en) 2004-07-27 2022-08-09 Beckman Coulter, Inc. Enhancing flow cytometry discrimination with geometric transformation
US20090287421A1 (en) * 2004-07-27 2009-11-19 George C Malachowski Enhancing Flow Cytometry Discrimination with Geometric Transformation
US9134220B2 (en) 2004-07-27 2015-09-15 Beckman Coulter, Inc. Enhancing flow cytometry discrimination with geometric transformation
USRE46559E1 (en) 2004-07-27 2017-09-26 Beckman Coulter, Inc. Enhancing flow cytometry discrimination with geometric transformation
WO2006073492A3 (en) * 2004-07-30 2007-07-05 Biovigilant Systems Inc Pathogen and particle detector system and method
US8218144B2 (en) 2004-07-30 2012-07-10 Azbil BioVigilant, Inc. Pathogen and particle detector system and method
US7430046B2 (en) * 2004-07-30 2008-09-30 Biovigilant Systems, Inc. Pathogen and particle detector system and method
US20070013910A1 (en) * 2004-07-30 2007-01-18 Jian-Ping Jiang Pathogen and particle detector system and method
CN100595564C (zh) * 2004-07-30 2010-03-24 百维吉伦特系统有限公司 病原体和粒子检测器系统和方法
US20060180517A1 (en) * 2005-01-12 2006-08-17 Beckman Coulter, Inc. Methods and apparatus for sorting particles hydraulically
US7392908B2 (en) 2005-01-12 2008-07-01 Beckman Coulter, Inc. Methods and apparatus for sorting particles hydraulically
US7738099B2 (en) 2005-07-15 2010-06-15 Biovigilant Systems, Inc. Pathogen and particle detector system and method
US20100108910A1 (en) * 2005-07-15 2010-05-06 Michael Morrell Pathogen and particle detector system and method
US7618770B2 (en) 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
TWI403454B (zh) * 2006-08-11 2013-08-01 Sokudo Co Ltd 用於監視與控制光阻分散系統之倒吸量的設備及方法
US20100065734A1 (en) * 2006-12-04 2010-03-18 The University Of Queensland Particle sorting apparatus and method
WO2008137475A2 (en) 2007-05-01 2008-11-13 Research Development Foundation Immunoglobulin fc libraries
US20090107893A1 (en) * 2007-10-26 2009-04-30 Becton, Dickinson And Company Deflection plate
EP2053380A2 (en) 2007-10-26 2009-04-29 Becton, Dickinson and Company, Wagner, Jaconda Deflection Plate
US7880108B2 (en) 2007-10-26 2011-02-01 Becton, Dickinson And Company Deflection plate
US8628976B2 (en) 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
US20090242799A1 (en) * 2007-12-03 2009-10-01 Bolotin Charles E Method for the detection of biologic particle contamination
US9594071B2 (en) * 2007-12-21 2017-03-14 Colin G. Hebert Device and method for laser analysis and separation (LAS) of particles
US20140220557A1 (en) * 2007-12-21 2014-08-07 Sean J. Hart Device and Method for Laser Analysis and Separation (LAS) of Particles
US20110149277A1 (en) * 2008-08-21 2011-06-23 Siemens Healthcare Diagnostics Inc. Multi-Layer Slides for Analysis of Urine Sediments
WO2010022019A1 (en) 2008-08-21 2010-02-25 Siemens Healthcare Diagnostics Inc. Multi-layer slides for analysis of urine sediments
US8462332B2 (en) 2008-08-21 2013-06-11 Siemens Healthcare Diagnostics, Inc. Multi-layer slides for analysis of urine sediments
US9945769B2 (en) 2009-02-06 2018-04-17 On-Chip Biotechnologies Co., Ltd. Disposable chip-type flow cell and flow cytometer using same
EP3907488A1 (en) 2009-02-06 2021-11-10 On-chip Biotechnologies Co., Ltd. Disposable chip-type flow cell and flow cytometer using same
US8951474B2 (en) 2009-02-06 2015-02-10 On-Chip Biotechnologies Co., Ltd. Disposable chip-type flow cell and flow cytometer using same
WO2010090279A1 (ja) 2009-02-06 2010-08-12 株式会社オンチップ・バイオテクノロジーズ 使い捨てチップ型フローセルとそれを用いたフローサイトメーター
US11002660B2 (en) 2009-02-06 2021-05-11 On-Chip Biotechnologies Co., Ltd. Disposable chip-type flow cell and flow cytometer using same
EP3671180A1 (en) 2010-01-15 2020-06-24 On-chip Biotechnologies Co., Ltd. Disposable chip-type flow cell and flow cytometer using the same
WO2011086990A1 (ja) 2010-01-15 2011-07-21 株式会社オンチップ・バイオテクノロジーズ 使い捨てチップ型フローセルとそれを用いたセルソーター
US10101261B2 (en) 2010-01-15 2018-10-16 On-Chip Biotechnologies Co., Ltd. Disposable chip-type flow cell and cell sorter using the same
EP4191227A1 (en) 2010-01-15 2023-06-07 On-chip Biotechnologies Co., Ltd. Disposable chip-type flow cell and flow cytometer using the same
US10724938B2 (en) 2010-01-15 2020-07-28 On-Chip Biotechnologies Co., Ltd. Disposable chip-type flow cell and cell sorter using the same
US9074977B2 (en) 2010-05-07 2015-07-07 Stc.Unm Multinode acoustic focusing for parallel flow cytometry analysis applications
US8830451B1 (en) * 2010-05-07 2014-09-09 Stc.Unm Multinode acoustic focusing for parallel flow cytometry analysis applications
US9116121B2 (en) * 2010-10-26 2015-08-25 Uh Ventures Limited Second generation low-cost particle counter
US20130229655A1 (en) * 2010-10-26 2013-09-05 University Of Hertfordshire Higher Education Corporation Second Generation Low-Cost Particle Counter
WO2012109133A1 (en) 2011-02-07 2012-08-16 Research Development Foundation Engineered immunoglobulin fc polypeptides
US9913887B2 (en) 2011-04-29 2018-03-13 Baylor College Of Medicine Ureaplasma vaccine and antibodies
CN103180713B (zh) * 2011-08-25 2015-07-15 索尼公司 移动微实体流中的运动相关误差的表征
CN103180713A (zh) * 2011-08-25 2013-06-26 索尼公司 移动微实体流中的运动相关误差的表征
WO2013039883A1 (en) 2011-09-12 2013-03-21 Abbvie Biotherapeutics Inc. Artificial nk cells and uses thereof
DE102011054659A9 (de) * 2011-10-20 2013-07-04 AeroMegt GmbH Verfahren und Vorrichtung zum Messen von Aerosolen in einem großen Volumenstrom
DE102011054659A1 (de) * 2011-10-20 2013-04-25 AeroMegt GmbH Verfahren und Vorrichtung zum Messen von Aerosolen in einem großen Volumenstrom
WO2013116698A2 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
US11193874B2 (en) 2012-03-30 2021-12-07 Sony Corporation Micro-particle sorting apparatus and method of determining a trajectory of an ejected stream carrying micro-particles
US10132735B2 (en) 2012-03-30 2018-11-20 Sony Corporation Microparticle sorting device and method of optimizing fluid stream therein
US9791362B2 (en) 2012-06-07 2017-10-17 Bio-Rad Laboratories, Inc. Fluid mixing and rinsing system for a flow cytometer
US9592483B2 (en) 2012-06-07 2017-03-14 Bio-Rad Laboratories, Inc. Fluid mixing and rinsing system for a flow cytometer
US10732088B2 (en) 2012-06-14 2020-08-04 Bio-Rad Laboratories, Inc. Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry
US10036697B2 (en) 2012-06-14 2018-07-31 Bio-Rad Laboratories, Inc. Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry
WO2013188770A1 (en) * 2012-06-14 2013-12-19 Bio-Rad Laboratories, Inc. Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry
US9551637B2 (en) 2012-06-14 2017-01-24 Bio-Rad Laboratories, Inc. Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry
US8582100B1 (en) * 2012-06-19 2013-11-12 The United States Of America, As Represented By The Secretary Of The Navy Remote multisensor optical particle monitor for flowing fluid systems
US8654329B2 (en) * 2012-06-19 2014-02-18 The United States Of America, As Represented By The Secretary Of The Navy Parallel multisensor optical particle sensors for flowing fluid systems
US9784659B2 (en) * 2012-11-08 2017-10-10 Sony Corporation Microparticle fractionating apparatus and method of fractionating microparticle
EP2917718A1 (en) * 2012-11-08 2015-09-16 Sony Corporation Microparticle fractionating apparatus and method of fractionating microparticle
US20150285726A1 (en) * 2012-11-08 2015-10-08 Sony Corporation Microparticle fractionating apparatus and method of fractionating microparticle
EP2917718B1 (en) * 2012-11-08 2022-08-10 Sony Group Corporation Microparticle fractionating apparatus and method of fractionating microparticle
US10241025B2 (en) 2013-01-28 2019-03-26 Sony Corporation Microparticle sorting device, and method and program for sorting microparticles
US11313784B2 (en) 2013-01-28 2022-04-26 Sony Corporation Microparticle sorting device, and method and program for sorting microparticles
US10309891B2 (en) 2013-10-16 2019-06-04 Sony Corporation Particle sorting apparatus, particle sorting method, and program
US20150131099A1 (en) * 2013-11-14 2015-05-14 Sony Corporation Light irradiation device, particle analysis device, and light irradiation method
US11119030B2 (en) 2014-02-13 2021-09-14 Sony Corporation Particle sorting device, particle sorting method, program, and particle sorting system
US10309892B2 (en) 2014-02-13 2019-06-04 Sony Corporation Particle sorting device, particle sorting method, program, and particle sorting system
US10302565B2 (en) * 2014-02-19 2019-05-28 Arizona Board Of Regents On Behalf Of Arizona State University System and method for isotopic analysis of calcium using laser induced fluorescence
US20170052116A1 (en) * 2014-02-19 2017-02-23 Arizona Board Of Regents On Behalf Of Arizona State University System and method for isotopic analysis of calcium using laser induced fluorescence
US10876952B2 (en) 2014-09-05 2020-12-29 Sony Corporation Droplet sorting device, droplet sorting method and program
US10386287B2 (en) 2014-09-05 2019-08-20 Sony Corporation Droplet sorting device, droplet sorting method and program
WO2016061199A2 (en) 2014-10-14 2016-04-21 Research Development Foundation Methods for generating engineered enzymes
US10723497B2 (en) * 2014-11-03 2020-07-28 Vanrx Pharmasystems Inc. Apparatus and method for monitoring and controlling the filling of a container with a pharmaceutical fluid in an aseptic environment
WO2016130516A1 (en) 2015-02-09 2016-08-18 Research Development Foundation Engineered immunoglobulin fc polypeptides displaying improved complement activation
US11725179B2 (en) 2015-05-12 2023-08-15 On-Chip Biotechnologies Co., Ltd. Single-particle analysis method, and system for performing said analysis
WO2017040380A2 (en) 2015-08-28 2017-03-09 Research Development Foundation Engineered antibody fc variants
US11204309B2 (en) 2015-10-19 2021-12-21 Sony Corporation Image processing device, fine particle sorting device, and image processing method
US10605714B2 (en) 2015-10-19 2020-03-31 Sony Corporation Image processing device, fine particle sorting device, and image processing method
US20190011350A1 (en) * 2015-12-23 2019-01-10 Siemens Healthcare Gmbh Flow cell for analyzing particles in a liquid to be examined
US10823657B2 (en) * 2015-12-23 2020-11-03 Siemens Healthcare Gmbh Flow cell for analyzing particles in a liquid to be examined
US20190212256A1 (en) * 2016-09-13 2019-07-11 Basf Coatings Gmbh Sensor for a virtually simultaneous measurement of a transmission and/or forward scattering and/or remission and for a simultaneous measurement of the transmission and forward scattering or transmission and remission of a liquid sample
US10837898B2 (en) * 2016-09-13 2020-11-17 Basf Coatings Gmbh Sensor for a virtually simultaneous measurement of a transmission and/or forward scattering and/or remission and for a simultaneous measurement of the transmission and forward scattering or transmission and remission of a liquid sample
RU2751443C2 (ru) * 2016-09-13 2021-07-13 БАСФ Коатингс ГмбХ Датчик для квазиодновременного измерения пропускания, и/или рассеяния вперед, и/или диффузного отражения и для одновременного измерения пропускания и рассеяния вперед или пропускания и диффузного отражения жидкого образца
US12105007B2 (en) 2016-09-16 2024-10-01 On-Chip Biotechnologies Co., Ltd. Fine particle dispensing device, fine particle analysis device, reaction detection device, and method using said devices
WO2018052137A1 (ja) 2016-09-16 2018-03-22 株式会社オンチップ・バイオテクノロジーズ 微粒子分注装置、微粒子解析装置、及び反応検出装置、並びにそれらを用いる方法
US20190025185A1 (en) * 2017-07-21 2019-01-24 Ikuo Katoh Particle counting apparatus, particle counting method, and particle containing sample
US10605716B2 (en) * 2017-07-21 2020-03-31 Ricoh Company, Ltd. Particle counting apparatus, particle counting method, and particle containing sample
US10780706B2 (en) * 2018-03-16 2020-09-22 Ricoh Company, Ltd. Discharging device and discharging method
DE102018210015A1 (de) * 2018-06-20 2019-12-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zur Sortierung von pulverförmigem oder stückförmigem Material
DE102018210015B4 (de) * 2018-06-20 2020-04-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zur Sortierung von pulverförmigem, partikelförmigem, granulatförmigem oder stückförmigem Material
US11287364B2 (en) * 2018-07-10 2022-03-29 Gerrit Jan van den Engh System, apparatus and method for off-axis illumination in flow cytometry
US11530977B2 (en) 2018-10-30 2022-12-20 Becton, Dickinson And Company Particle sorting module with alignment window, systems and methods of use thereof
US11035776B2 (en) * 2018-10-30 2021-06-15 Becton, Dickinson And Company Particle sorting module with alignment window, systems and methods of use thereof
WO2021178637A1 (en) 2020-03-05 2021-09-10 Iowa State University Research Foundation, Inc. IMMUNOGENIC AND VACCINE COMPOSITIONS AGAINST SARS-CoV-2
WO2023239940A1 (en) 2022-06-10 2023-12-14 Research Development Foundation Engineered fcriib selective igg1 fc variants and uses thereof
RU218768U1 (ru) * 2022-12-27 2023-06-09 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Устройство для анализа содержания аэрозолей и паров углеводородов в атмосфере

Also Published As

Publication number Publication date
US3826364A (en) 1974-07-30
JPS49109093A (no) 1974-10-17
DE2246380C2 (de) 1982-11-04
CA974193A (en) 1975-09-09
DE2246380A1 (de) 1973-12-20

Similar Documents

Publication Publication Date Title
US3826364B1 (no)
US4538733A (en) Particle sorter with neutralized collection wells and method of using same
EP1841537B1 (en) Methods and apparatus for sorting particles hydraulically
US4230558A (en) Single drop separator
IL96689A0 (en) Process and apparatus for the genetic transformation of cells
GR3033347T3 (en) Apparatus and methods for cell isolation and collection
GB1532057A (en) Analysis
GB1375003A (no)
GB746828A (en) Method of wet screening and apparatus therefor
US5735403A (en) Apparatus for removal of fine particles in material flow system
ES8700949A1 (es) Un aparato para eliminar liquido de un material solido en forma de particulas de tamano no uniforme
GB1416572A (en) Electrostatic precipitator
US2879889A (en) Apparatus for separating mixed products having specific gravities less than one
ES365656A1 (es) Procedimiento para la separacion de material granulado con peso diferencial.
US3750881A (en) Color sorter
JPS5742355A (en) Electrostatic separator
ATE17089T1 (de) Verfahren und vorrichtung zur abtrennung von teilchen aus einem gasstrom.
CA1221854A (en) Observation chamber for a powdered material
DE19953424B4 (de) Verfahren und Anordnung zur Charakterisierung und Vereinzelung von multizellulären Sphäroiden
GB756198A (en) Method and apparatus for separating mixtures of solid materials in a heavy medium
RU2072263C1 (ru) Способ измельчения использованных автопокрышек и устройство для его осуществления
DE19947597C1 (de) Aerosolgenerator
GB900242A (en) Improvements in or relating to a method of and apparatus for mixing pulverulent and/or fine-grain materials
US2696373A (en) Apparatus for the production of aerosols
US3212821A (en) Method of inspecting articles and apparatus therefor

Legal Events

Date Code Title Description
RR Request for reexamination filed

Effective date: 19840210

B1 Reexamination certificate first reexamination