US3598294A - Inhalation-responsive aerosol dispenser - Google Patents

Inhalation-responsive aerosol dispenser Download PDF

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Publication number
US3598294A
US3598294A US876263A US3598294DA US3598294A US 3598294 A US3598294 A US 3598294A US 876263 A US876263 A US 876263A US 3598294D A US3598294D A US 3598294DA US 3598294 A US3598294 A US 3598294A
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United States
Prior art keywords
charging
metering valve
latch
mouthpiece
inhalation
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Expired - Lifetime
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US876263A
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English (en)
Inventor
Nathan D Hedrick
Albert M Hughes Jr
Paul B Mckeehan
Charles G Thiel
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Dart Industries Inc
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Dart Industries Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans

Definitions

  • An inhalation-responsive medicament dispenser provided with a housing having therein an aerosol-dispensing device comprising a container equipped with a metering valve spring biased outwardly toward a charging position and movable inwardly into a discharging position.
  • a main spring engages the housing and the aerosol container to bias the metering valve toward its discharging position.
  • a charging lever opposes the action of the main spring to enable the container to move to a position permitting the metering valve to occupy its charging position, and a latch releasably retains the charging lever in a position corresponding to the charging position of the metering valve.
  • An inhalation-responsive vane releases the latch, upon inhalation by the patient through a mouthpiece with which the dispenser is equipped, whereupon the main spring moves the container into a position corresponding to the discharging position of the metering valve, the latter then discharging a metered amount of medicament from the aerosol container into the mouthpiece for inhalation by the patient.
  • Pivotally connected to the housing is a cover which encloses the mouthpiece when the dispenser is not in use.
  • An actuating cam pivotally connected to the cover, and responsive to closing movement thereof, sets the charging lever, the latch and the vane in positions corresponding to the charging position of the metering valve. Subsequently, the cover may be opened so that the patient may inhale through the mouthpiece to obtain a metered amount of medicament in the manner previously recited.
  • the present invention relates in general to an inhalationresponsive dispenser for administering a metered quantity of a medicament to a patient in inhalation therapy, the medicament being carried by a self-propelling vehicle in an aerosoldispensing device.
  • the invention contemplates an inhalation-actuable dispenser which utilizes an aerosol-dispensing means comprising a container equipped with a metering valve or valve means movable between a charging position and a discharging position, the metering valve means receiving a metered chargefrom the container when in its charging position and discharging this metered charge when displaced into its discharging position.
  • the metered charge is dispensed into a stream of air being inhaled by the patient through a mouthpiece with which the dispenser is equipped.
  • an inhalation-responsive dispenser of the type under consideration includes a housing in which the aerosol container is movably mounted, the metering valve means engaging a seat in the housing which is provided with a passage means for conveying a discharge from the metering valve means to the mouthpiece.
  • a main spring means biases the container in a direction to position the metering valve means in its discharging position.
  • a charging means opposes the action of the spring means to enable the container to move into a position such that the metering valve means may occupy its charging position.
  • a latch means releasably retains the container in the position corresponding to the charging position of the metering valve means.
  • An inhalation-responsive means in the air passage leading to the mouthpiece releases the latch means so that the main spring means produces movement of the container into a position corresponding to the discharging position of the metering valve means, whereby the latter discharges a metered amount of medicament from the container into the mouthpiece for inhalation by the patient.
  • the aerosoldispensing device is equipped with a metering valve means which discharges in response to inward movement, relative to the container, into an inner, discharging position from an outer, charging position, the device being equipped with an auxiliary spring means which biases the metering valve means toward its outer, charging position.
  • the dispenser is cockcd by the simple act of closing the cover over the mouthpiece, which is an important feature. Subsequent opening of the cover readies the dispenser for use.
  • FIG. 1 is a longitudinal sectional view of an inhalation-actuable aerosol dispenser which embodies the invention, showing the cover of the dispenser closed and showing the dispenser cocked;
  • FIG. 2 and 3 are sectional views respectively taken along the arrowed lines 2-2 and 3-3 of FIG. 1;
  • FIG. 4 is a sectional view taken along the arrowed line 4-4 of FIG. 2;
  • FIG. 5 is a sectional view taken along the arrowed line 5-5 of FIG. 4;
  • FIG. 6 is a view similar to FIG. 4, but showing the cover of the dispenser opened;
  • FIG. 7 is a view similar to FIG. 6, but showing the dispenser of the invention "triggered to discharge a metered amount of medicament;
  • FIG. 8 is a view similar to FIG. 7, but showing the cover in the process of being closed to recock the dispenser
  • FIG. 9 is a fragmentary view duplicating a portion of FIG. 8 and showing various parts in the positions they occupy just before the dispenser is completely cocked;
  • FIG. 10 is an exploded perspective view showing parts of a charging means and a latch means of the dispenser of the invention.
  • FIG. 11 is a perspective view of a partition forming part of the housing of the dispenser.
  • FIG. 12 is a perspective view of an inhalation actuable vane forming part of the dispenser.
  • the aerosol container 28 is slidnble upwardly and downwardly in a guidsway 30 in a member 32 disposed in the compartment 2 and releassbly secured therein by a suitable latch 34.
  • the container 28 is provided at its lower end with a metering valve means 36 engageable with a seat 38 communicatlng through a passage means 40 with a mouthpiece 42 forming part of the member 32.
  • the mouthpiece d2 forms the terminus of an air passage. designated generally by the numeral 44, through the housing 22, the inlet es of the air passage so being adjacent the latch 36.
  • the metering valve means so is similar to that disclosed in U.S. Pat. No. 2,72i,0l0, granted Get. 18, 1955 to Philip Meshberg.
  • the metering valve means 36 briefly it includes a housing 48 within the container 28. Reciprocable in the housing as is a metering valve 5% having a tubular stem 52 which projects from the housing 48 and the container 23 into the seat 35 through an annular seal 54. A lateral port so in the tubular stem 52 communicates with the interior of this stem.
  • the mctering valve 50 is in its charging position and the port ss is located axially outwardly of the annular seal so.
  • the metering valve 50 isin its discharging position and the port-5ev is axially inwardly oi the nnnulnrseal 5d.
  • the metering valve 50 is biased axially outwardly toward its charging position, shown in FIG. 6, by an auxiliary spring means comprising a compression coil spring 58 seated at one end against an external collar on the metering valve and at is other end against the housing 48.
  • the metering valve 50 includes an axially inwardly extending pin 60 carrying a collar 62 which is engageabie with an annular seal 64, when the metering valve is in its discharging position, FIG. 7, to close a passage 66 interconnecting the interior of the housing 48 and the interior of the container 28.
  • the collar 62 disengages the annular seal 64 to open the passage 66.
  • a metered charge may flow from the interior of the container 28 into the housing 48 through the passage 66.
  • the metered charge is discharged from the interior of the housing 48 through the port 56 and the tubular stem 52, into the passage means 40 leading to the mouthpiece 42.
  • the collar 62 closes the passage 66 to prevent further flow from the interior of the container 28.
  • the port was located axially outwardly of the annular seal 54 to disconnect the tubular stem 52 from the interior of the housing 48.
  • the compression coil spring 58 forming part ofthe metering valve means 36 biases the aerosol container 28 upwardly into its FIG. 6 position, corresponding to the charging position oi the metering valve means.
  • a main spring means 70 is capable of overcoming the spring 58 to displace the container 28 downwardly into its FIG. 7 position, corresponding to the discharging position of the metering valve 50.
  • the main spring means 70 comprises a relatively heavy coil spring '72 acting in compression between the upper end wall of the housing 22 and a driver 74 movable upwardly and downwardly along tracks 76, FIG. 3.
  • the driver 74 transmits the force of the spring 72 to the upper, closed end of the aerosol container 20 to bias it downwardly into its discharging position, FIG. 7.
  • the charging lever 82 extends through an aperture 86 in the driver 74 and is cngagcablc with a knife edge 00 forming the upper edge of the aperture.
  • the charging lever 02 when the charging lever 02 is pivoted upwardly, it. acts through the driver 74 to compress the spring 72 and permit the spring 50 in the metering valve means 36 to displace the container 20 upwardly into the position thereof corresponding to the charging position of the metering valve 50.
  • the inhalation-actuabie vane means 98 includes 21 depending vane I00 disposed in and closely fitting the vane compartment 94.
  • the vane 100 is provided at its upper end with a pivot shaft 102 suitably pivotally mounted in the housing 22 so that the vane 100 can swing back and forth in the vane compartment 94 between a latching position, FIG. 6, and a latch-releasing position, FIG. 7.
  • the pivot shaft I02 is provided thereon within the actuator compartment 92 with a flat 104 for a purpose to be described. It will be apparent that, when the patient inhales through the mouthpiece 42, the flow of air through the passage 44, as shown in FIG. 7, pivots the vane 100 from its latching position to its latch-releasing position.
  • the dispenser 20 further includes latch means I I0 in the actuator compartment 92 for releasably retaining the aerosoldispensing device 26 in its charging condition, the latch means being releasable by the inhalation-responsive vane means 98 to permit the main spring means 70 to place the aerosoldispensing device in its discharging condition, whereby it discharges a metered amount into the stream of air being inhaled by the patient through the mouthpiece 42.
  • the latch means includes a generally upright latch 112 having at its lower end a pivot shaft I14 seated in a semicylindrical bearing I16 carried by the partition 96 and one sidewall of the housing 22.
  • the latch 112 is provided at its upper end with a hook I18 adapted to hook over the flatted portion of the vane pivot shaft I02, as shown in FIG. 6, when the vane I00 is in its latching position.
  • the vane pivot shaft I02 is rotated suiticiently to permit the end I30 oi the hook [iii to slide across the flat I04 to release the latch means IIO.
  • the hook and I20 may slide across the flat I04 in engaging the latch I12 with the vane pivot shaft I02. prior to pivoting the vane I00 into its latching position.
  • the latch I12 and the charging lever 82 are interconnected within the actuator compartment 92 by a link I24 pivotally connected to the latch 112 Intermediate its ends at 126 and to the charging lever 82 at its free end, at 128.
  • the relationship between the link I24, the charging lever 82 and the latch I12 is such that as the latch is hooked over the vane pivot shaft I02, FIG. 6, the charging lever 02 is also pivoted upwardly into a position corresponding to the charging position of the metering valve means 36.
  • the latch moans III) releasably retains the charging means 80 in a position corresponding to the charging position of the metering valve means 36.
  • the charging means 00 and the latch means 110 are placed in their foregoing locked positions by an actuating means 130 in the actuator compartment 92, such actuating means also serving to place the vane I00 in its latching posi" tion so that the hook I10 oi the latch I12 is hooked over the flatted portion oitho vane pivot shaft I02.
  • actuating means I30 it is pivotally connected at I32 to a cover I34 for the mouthpiece 42.
  • the cover I34 is pivotally connected to the housing 22, iii I36, for pivotal movement between a closed position, FIGS. I to 5, and an open position, FIGS. 6 and 7.
  • the actuating means I30 comprises a bifurcated cam means which extends upwardly from the cover I34 into the actuator compartment 92 and which terminates in two branch cams I40 and I42.
  • the com I40 as best shown in FIGS. 7 and 8, engages a pin 144 on the latch 112 to pivot the latch into latching engagement with the vane pivot shaft I02, as will be apparent by considering FIGS. 8, 9 and 4 in that order. This occurs, as will be evident from the drawings, in response to closing movement otthc cover I34.
  • the link I24 acts on the charging lever 82 to pivot it upwardly into a position corresponding to the charging position of the metering valve means 36.
  • the cam I42 engages an arm I46 on the vane pivot shait I02, as shown in FIG. 9, to pivot the vane into its latching position, FIG. 4.
  • the cam I42 pivots the vane I00 into its latching position as the end I20 oi'thc hook IIS moves across the flat I04 on the vane pivot shalt I02. Consequently, as the vane I00 is displaced into its latching position, the flatted portion of the vane pivot shaft 102 is rotated into hooked relation with the latch hook 118, as shown in FIG. 4, and also in FIG. 6.
  • the cover 134 may be opened to disengage the cams 140 and 142 from the latch 112 and the vane I00.
  • the cam 142 is provided thereon with a projection 148 which is engageable with one edge of the semicylindrical bearing 116 to releasably retain the actuating means 130 in a position to hold the cover 134 closed. Upon opening the cover 134 manually, the projection 148 disengages the bearing 116.
  • the cover 134 is opened, as shown in flG. 6. This makes the mouthpiece 42 accessible, and also disengages the cams 140 and 142 from the latch pin 144 and from the vane pivot shaft arm 146, respectively.
  • a cover for said mouthpiece pivotally connected to said housing for movement between an open. and. a closed position
  • aerosobdispensing means in said housing and capable of being placed in either a charging condition or a discharging condition and communicating with said mouthpiece;
  • latch means for releasably retaining said aerosoldispensing means in its charging condition
  • actuating means connected to said cover and responsive to movement thereof between said open and said closed position for actuating said charging means and said latch means;
  • inhalation-responsive means in said air passage, and actuable by air flowing therethrough toward said mouthpiece, for releasing said latch means so that said spring means places said aerosol-dispensing means in its discharging condition, whereby said aerosol-dispensing means discharges into said mouthpiece.
  • a cover for said mouthpiece pivotally connected to said housing for movement between an open and a closed position
  • aerosol-dispensing means in said housing and including a container having a metering valve means relatively movable between charging and discharging positions of said metering valve means and communicating with said mouthpiece;
  • charging means for affording movement of said metering valve means and said container into said charging position of said metering valve means in opposition to the action of said spring means;
  • latch means for releasably retaining said metering valve means in said charging position in opposition to the action of said spring means
  • actuating means connected to said cover and responsive to movement thereof between said open and said closed osition for actuating said charging means and said latch means;
  • a housing havi g an air passage therethrough which terminat s in a mouthpiece
  • aeros dispensing means in said housing and including a container having a metering valve means relatively movable between charging and discharging positions of said metering valve means, said metering valve means being spring biased outwardly toward said charging osition;
  • charging means for opposing the action of said spring means to enable said container to move away from sai seat so that said metering valve means may occupy said charging position;
  • latch means for releasably retaining said charging means in a position corresponding to said charging position of said metering valve means
  • actuating means connected to said cover and responsive to closing movemen thereof for actuating said charging means and said latch means;
  • inhalation-responsive vane means in said air passage, and actuable by air flowing therethrough toward said mouthpiece, for releasing said latch means so that said spring means produces movement of said container toward said seat to move said metering valve means into said discharging position, whereby said metering valve means discharges a metered amount from said container into said mouthpiece.
  • said charging means includes a charging lever pivotally connected at one end to said housing;
  • said charging lever is connected intermediate its ends to said spring means.
  • said vane means includes a vane having at one end a pivot shaft journaled in said housing;
  • said pivot shaft has a flat thereon
  • said latch means includes a latch provided with a hook engageable with said pivot shaft and having an end slidable across said flat to release said latch means.
  • said vane means includes a vane pivotable between a latching position and a latch-releasing position
  • said actuating means includes means for pivoting said vane into said latching position.
  • said actuating means includes cam means pivotally connected to said cover and having a cam in engagement with said latch means;
  • said latch means is connected to said charging means.
  • said vane means includes a vane pivotable in said housing between a latching position and a latch-releasing position;
  • said cam means includes a cam for pivoting said vane into its latching position concurrently with actuation of said charging means and said latch means.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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US876263A 1969-11-13 1969-11-13 Inhalation-responsive aerosol dispenser Expired - Lifetime US3598294A (en)

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US87626369A 1969-11-13 1969-11-13

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US (1) US3598294A (de)
AT (1) AT308959B (de)
BE (1) BE758834A (de)
CA (1) CA947170A (de)
CH (1) CH533452A (de)
DE (1) DE2055734A1 (de)
DK (1) DK132993C (de)
ES (1) ES192830Y (de)
FI (1) FI51279C (de)
FR (1) FR2069300A5 (de)
GB (1) GB1335378A (de)
IE (1) IE34721B1 (de)
IL (1) IL35639A (de)
NL (1) NL7016022A (de)
NO (1) NO125715B (de)
SE (1) SE378521B (de)
ZA (1) ZA707660B (de)

Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045419A1 (de) * 1980-08-04 1982-02-10 FISONS plc Inhalationsvorrichtung zum Verabreichen von Medikamenten
US4664107A (en) * 1983-10-28 1987-05-12 Minnesota Mining And Manufacturing Company Inhalation activatable dispensers
US4819834A (en) * 1986-09-09 1989-04-11 Minnesota Mining And Manufacturing Company Apparatus and methods for delivering a predetermined amount of a pressurized fluid
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
US5069204A (en) * 1989-08-23 1991-12-03 Riker Laboratories, Inc. Inhaler
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
AU637649B2 (en) * 1989-11-14 1993-06-03 Riker Laboratories, Inc. Inhalation device and protective casing therefor
US5217004A (en) * 1990-12-13 1993-06-08 Tenax Corporation Inhalation actuated dispensing apparatus
US5224472A (en) * 1990-02-09 1993-07-06 Solange Quenderff Inhalation device
WO1994011044A2 (en) 1992-11-12 1994-05-26 Minnesota Mining And Manufacturing Company Powder inhaler
US5347998A (en) * 1990-07-09 1994-09-20 Minnesota Mining And Manufacturing Company Breath actuated inhaler having an electromechanical priming mechanism
US5355873A (en) * 1990-07-27 1994-10-18 Bon F Del An inhalation device and method having a variably restrictable air inlet that allows the inhalation force required to overcome a locking element to be changed
US5408994A (en) * 1990-11-14 1995-04-25 Minnesota Mining And Manufacturing Company Inhalation device
US5447150A (en) * 1990-12-01 1995-09-05 Norton Healthcare Limited Medicament dispensing device
US5511540A (en) * 1992-08-18 1996-04-30 Minnesota Mining And Manufacturing Company Inhalation device
US6012454A (en) * 1989-04-28 2000-01-11 Minnesota Mining And Manufacturing Company Dry powder inhalation device
WO2000024443A1 (en) * 1998-10-27 2000-05-04 Innovative Devices, L.L.C. INHALATION ACTUATED DEVICE FOR USE WITH METERED DOSE INHALERS (MDIs)
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
US6415784B1 (en) * 1998-09-24 2002-07-09 Astrazeneca Ab Inhaler
US6439227B1 (en) * 2000-09-25 2002-08-27 Microdrug Ag Breath-actuation
US20020170928A1 (en) * 2001-05-15 2002-11-21 Jerry Grychowski Medicament applicator
US6553988B1 (en) * 2000-06-09 2003-04-29 Norton Healthcare, Inc. Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
WO2003002169A3 (en) * 2001-06-26 2003-11-20 Ivax Corp An improved aerosol actuator
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
US20040134488A1 (en) * 2001-04-20 2004-07-15 Davies Michael Birsha Medicament dispenser
WO2004071561A1 (en) * 2003-02-11 2004-08-26 Bespak Plc Dispensing apparatus
US20040237961A1 (en) * 1995-06-08 2004-12-02 Snow John Medlin Inhalation actuated device for use with metered dose inhalers (MDIs)
US20050209558A1 (en) * 2002-06-03 2005-09-22 Eduard Marx Dose indicators and dispensing canister-indicator assemblies
US20060071027A1 (en) * 2002-11-07 2006-04-06 Davies Michael B Container
WO2007009872A1 (de) * 2005-07-18 2007-01-25 Alfred Von Schuckmann Inhalator für pulverförmige, insbesondere medizinische substanzen
US7185648B1 (en) 1999-10-21 2007-03-06 Paul Kenneth Rand Medicament dispenser
US7461650B1 (en) * 1999-10-21 2008-12-09 Glaxo Group Limited Medicament dispenser
US20090050149A1 (en) * 2006-03-10 2009-02-26 Astrazeneca Ab Inhaler for Powdery Substances
US20090101731A1 (en) * 2006-03-14 2009-04-23 Tiziano Redaelli Rotating Nozzle And Rotating Nozzle Device For Dispensing Pressurized Fluids
WO2012106382A1 (en) 2011-01-31 2012-08-09 Genoa Pharmaceuticals, Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US8357696B2 (en) 2005-05-18 2013-01-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
EP2594272A2 (de) 2005-05-18 2013-05-22 Mpex Pharmaceuticals, Inc. Aerosolierte Fluorchinolone und Verwendungen davon
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10028966B2 (en) 2014-01-10 2018-07-24 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US20210008302A1 (en) * 2018-03-07 2021-01-14 Astrazeneca Ab Inhaler
EP3782604A1 (de) 2013-07-31 2021-02-24 Windward Pharma, Inc. Tyrosinkinase-inhibitor-aerosolverbindungen und verwendungen davon
US11071837B2 (en) * 2015-12-21 2021-07-27 Kindeva Drug Delivery L.P. Dose release firing systems and medicinal inhalers comprising same
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3037917A1 (de) * 1980-10-08 1982-05-13 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Inhaliergeraet
NZ212911A (en) * 1984-07-31 1988-06-30 Glaxo Group Ltd Aerosol dispensing device; actuator lever acts when cover in open position
US4648393A (en) * 1984-11-02 1987-03-10 Ackrad Laboratories, Inc. Breath activated medication spray
AT393223B (de) * 1986-01-21 1991-09-10 Glaxo Group Ltd Einrichtung zur abgabe einer mischung eines treibmittels und eines produktes
FR2615106B1 (fr) * 1987-05-12 1993-12-03 Glaxo Inc Appareil pulverisateur d'aerosol a declenchement par inhalation
DE4015367A1 (de) * 1990-05-12 1991-11-14 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer mindestens ein medium
US7296567B2 (en) 2002-09-25 2007-11-20 3M Innovative Properties Company Breath actuated aerosol dispensers
GB201904844D0 (en) * 2019-04-05 2019-05-22 Nicoventures Trading Ltd Aerosol generating system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3001524A (en) * 1956-03-21 1961-09-26 Riker Laboratories Inc Aerosol dispensing apparatus
US3157179A (en) * 1962-08-31 1964-11-17 Merck & Co Inc Aerosol device
US3302834A (en) * 1964-08-11 1967-02-07 Fisous Pharmaceuticals Ltd Aerosol applicators

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3001524A (en) * 1956-03-21 1961-09-26 Riker Laboratories Inc Aerosol dispensing apparatus
US3157179A (en) * 1962-08-31 1964-11-17 Merck & Co Inc Aerosol device
US3302834A (en) * 1964-08-11 1967-02-07 Fisous Pharmaceuticals Ltd Aerosol applicators

Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045419A1 (de) * 1980-08-04 1982-02-10 FISONS plc Inhalationsvorrichtung zum Verabreichen von Medikamenten
US4664107A (en) * 1983-10-28 1987-05-12 Minnesota Mining And Manufacturing Company Inhalation activatable dispensers
AU578915B2 (en) * 1983-10-28 1988-11-10 Riker Laboratories, Inc. Inhalation activatable dispenser
US4819834A (en) * 1986-09-09 1989-04-11 Minnesota Mining And Manufacturing Company Apparatus and methods for delivering a predetermined amount of a pressurized fluid
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
US6012454A (en) * 1989-04-28 2000-01-11 Minnesota Mining And Manufacturing Company Dry powder inhalation device
US5069204A (en) * 1989-08-23 1991-12-03 Riker Laboratories, Inc. Inhaler
AU637649B2 (en) * 1989-11-14 1993-06-03 Riker Laboratories, Inc. Inhalation device and protective casing therefor
US5224472A (en) * 1990-02-09 1993-07-06 Solange Quenderff Inhalation device
US5347998A (en) * 1990-07-09 1994-09-20 Minnesota Mining And Manufacturing Company Breath actuated inhaler having an electromechanical priming mechanism
US5355873A (en) * 1990-07-27 1994-10-18 Bon F Del An inhalation device and method having a variably restrictable air inlet that allows the inhalation force required to overcome a locking element to be changed
US5408994A (en) * 1990-11-14 1995-04-25 Minnesota Mining And Manufacturing Company Inhalation device
US5447150A (en) * 1990-12-01 1995-09-05 Norton Healthcare Limited Medicament dispensing device
US5217004A (en) * 1990-12-13 1993-06-08 Tenax Corporation Inhalation actuated dispensing apparatus
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
US5511540A (en) * 1992-08-18 1996-04-30 Minnesota Mining And Manufacturing Company Inhalation device
WO1994011044A2 (en) 1992-11-12 1994-05-26 Minnesota Mining And Manufacturing Company Powder inhaler
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
US6357442B1 (en) * 1995-06-08 2002-03-19 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIS)
US20040237961A1 (en) * 1995-06-08 2004-12-02 Snow John Medlin Inhalation actuated device for use with metered dose inhalers (MDIs)
US6729324B2 (en) 1995-06-08 2004-05-04 Innovative Devices, Llc. Inhalation actuated device for use with metered dose inhalers (MDIs)
US6415784B1 (en) * 1998-09-24 2002-07-09 Astrazeneca Ab Inhaler
WO2000024443A1 (en) * 1998-10-27 2000-05-04 Innovative Devices, L.L.C. INHALATION ACTUATED DEVICE FOR USE WITH METERED DOSE INHALERS (MDIs)
US7461650B1 (en) * 1999-10-21 2008-12-09 Glaxo Group Limited Medicament dispenser
US7185648B1 (en) 1999-10-21 2007-03-06 Paul Kenneth Rand Medicament dispenser
US7637260B2 (en) 2000-06-09 2009-12-29 Norton Healthcare Limited Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
US20040025867A1 (en) * 2000-06-09 2004-02-12 Michael Holroyd Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
US8225780B2 (en) 2000-06-09 2012-07-24 Norton Healthcare Limited Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
US6553988B1 (en) * 2000-06-09 2003-04-29 Norton Healthcare, Inc. Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
US20100065050A1 (en) * 2000-06-09 2010-03-18 Norton Healthcare Limited Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
US6439227B1 (en) * 2000-09-25 2002-08-27 Microdrug Ag Breath-actuation
US20040134488A1 (en) * 2001-04-20 2004-07-15 Davies Michael Birsha Medicament dispenser
US6745760B2 (en) * 2001-05-15 2004-06-08 Trudell Medical International Medicament applicator
US20020170928A1 (en) * 2001-05-15 2002-11-21 Jerry Grychowski Medicament applicator
EP2258429A1 (de) * 2001-06-26 2010-12-08 Norton Healthcare Limited Verbesserter Aerosol-Regler
AU2002322314B2 (en) * 2001-06-26 2006-08-17 Norton Healthcare, Ltd. An improved aerosol actuator
WO2003002169A3 (en) * 2001-06-26 2003-11-20 Ivax Corp An improved aerosol actuator
US7464708B2 (en) 2002-06-03 2008-12-16 3M Innovative Properties Company Dose indicators and dispensing canister-indicator assemblies
US20050209558A1 (en) * 2002-06-03 2005-09-22 Eduard Marx Dose indicators and dispensing canister-indicator assemblies
US20060071027A1 (en) * 2002-11-07 2006-04-06 Davies Michael B Container
US20060289005A1 (en) * 2003-02-11 2006-12-28 Jones Matthew M Dispensing Apparatus
WO2004071561A1 (en) * 2003-02-11 2004-08-26 Bespak Plc Dispensing apparatus
US8357696B2 (en) 2005-05-18 2013-01-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US10987357B2 (en) 2005-05-18 2021-04-27 Horizon Orphan, LLC Aerosolized fluoroquinolones and uses thereof
EP2594272A2 (de) 2005-05-18 2013-05-22 Mpex Pharmaceuticals, Inc. Aerosolierte Fluorchinolone und Verwendungen davon
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
WO2007009872A1 (de) * 2005-07-18 2007-01-25 Alfred Von Schuckmann Inhalator für pulverförmige, insbesondere medizinische substanzen
US20090260626A1 (en) * 2005-07-18 2009-10-22 Alfred Von Schuckmann Inhaler for Powdery, Especially Medical Substances
US20090056710A1 (en) * 2006-03-10 2009-03-05 Alfred Von Schuckmann Inhaler for Powdery Substances
US20090050149A1 (en) * 2006-03-10 2009-02-26 Astrazeneca Ab Inhaler for Powdery Substances
US8132565B2 (en) 2006-03-10 2012-03-13 Alfred Von Schuckmann Inhaler for powdery substances
US8261737B2 (en) 2006-03-10 2012-09-11 Alfred Von Schuckmann Inhaler for powdery substances
US20090101731A1 (en) * 2006-03-14 2009-04-23 Tiziano Redaelli Rotating Nozzle And Rotating Nozzle Device For Dispensing Pressurized Fluids
US9326936B2 (en) 2008-10-07 2016-05-03 Raptor Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US10722519B2 (en) 2008-10-07 2020-07-28 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
US11020481B2 (en) 2008-10-07 2021-06-01 Horizon Orphan Llc Topical use of levofloxacin for reducing lung inflammation
US9717738B2 (en) 2008-10-07 2017-08-01 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
US10149854B2 (en) 2008-10-07 2018-12-11 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US10792289B2 (en) 2009-09-04 2020-10-06 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10231975B2 (en) 2009-09-04 2019-03-19 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
WO2012106382A1 (en) 2011-01-31 2012-08-09 Genoa Pharmaceuticals, Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
EP4059499A1 (de) 2011-01-31 2022-09-21 Avalyn Pharma Inc. Aerosolförmige pirfenidon- und pyridonanalogverbindungen und verwendungen davon
EP3782604A1 (de) 2013-07-31 2021-02-24 Windward Pharma, Inc. Tyrosinkinase-inhibitor-aerosolverbindungen und verwendungen davon
US10028966B2 (en) 2014-01-10 2018-07-24 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US11071837B2 (en) * 2015-12-21 2021-07-27 Kindeva Drug Delivery L.P. Dose release firing systems and medicinal inhalers comprising same
US20210008302A1 (en) * 2018-03-07 2021-01-14 Astrazeneca Ab Inhaler
US11964097B2 (en) * 2018-03-07 2024-04-23 Astrazeneca Ab Inhaler
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof

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ZA707660B (en) 1971-08-25
DK132993B (da) 1976-03-08
AT308959B (de) 1973-07-25
CH533452A (de) 1973-02-15
IE34721L (en) 1971-05-13
FR2069300A5 (de) 1971-09-03
NO125715B (de) 1972-10-23
ES192830Y (es) 1975-01-16
CA947170A (en) 1974-05-14
ES192830U (es) 1974-09-16
NL7016022A (de) 1971-05-17
BE758834A (fr) 1971-05-12
FI51279C (fi) 1976-12-10
IL35639A0 (en) 1971-01-28
SE378521B (de) 1975-09-08
IE34721B1 (en) 1975-07-23
DK132993C (da) 1976-08-02
IL35639A (en) 1973-05-31
FI51279B (de) 1976-08-31
DE2055734A1 (de) 1971-05-19
GB1335378A (en) 1973-10-24

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