IL35639A - Inhalation responsive aerosol dispenser - Google Patents

Description

Inhalation Beapoasive Aerosol Dispenser INHALATION RESPONSIVE AERHOSOL DISPENSER The present invention relates in general to an in- I halation responsive dispenser for administering a metered quantity of a medicament to a patient in inhalation therapy, the medicament being carried by a self-propelling vehicle in an aerosol dispensing device.

More particularly, the invention contemplates an inhalation actuable dispenser which utilizes an aerosol dispensing device comprising a container equipped with a meter-ing valve movable between a charging position and a discharg ing position, the metering valve receiving a metered charge from the container when in its charging position and discharging this metered charge when displaced into its discharging position. The metered charge is dispensed into a stream of air being inhaled by the patient through a mouth-piece with which the dispenser is equipped.

Convention lly, an inhalation responsive dispenser of the type under consideration includes a housing in which the aerosol container is movably mounted, the metering valve engaging a seat in the housing which is provided with a passage means for conveying a discharge from the metering valve to the mouthpiece. A main spring biases the container in a direction to position the metering valve in its discharging position. A charging apparatus opposes -the action of the spring means to enable the container to move into a position such that the metering valve may occupy its charging position. A latch releasably retains the charging apparatus and thus the container in the position corresponding to the charging position of the metering valve. An inhalation responsive means in the air passage leading to the mouthpiece releases the latch so that the main spring produces movement of the container into a position corresponding to the discharging position of the metering valve, whereby the latter discharges a metered amount of medicament from the container into the mouthpiece for inhalation by the patient.

In the particular type of inhalation responsive medicament dispenser selected for disclosure herein, the aerosol dispensing device is equipped with a metering valve which discharges in response to inward movement of a member thereof, relative to the container, into an inner, discharging position from an outer, charging position, the device being equipped with an auxiliary spring which biases the movable member of the metering valve toward its outer charging position. The main spring hereinbefore referred to is a separate spring external of the container, for biasing the container toward the seat for the metering valve so as to bias a member of the metering valve inwardly relative to the container toward the discharging position of the metering valve, in opposition to the action of the auxiliary spring with which the aerosol dispensing device is equipped.

The present invention provides an inhalation actu-able medicament dispenser of the foregoing general character which includes an actuator connected to a pivoted cover for the mouthpiece, and responsive to closing movement of the cover, for placing the charging device, the latch and the inhalation responsive device in their respective positions corresponding to the charging position of the metering valve. Thus, the dispenser is made ready for use upon subsequent opening of the cover by the simple act of closing the cover over the mouthpiece.

The invention also provides an actuator which comprises a cam pivotally connected to the cover and provided with cam surfaces for placing the charging device, the latch and the inhalation responsive device in their positions corresponding to the charging position of the metering valve.

According to the present invention there is provided an inhalation actuable dispenser for use with an aerosol container, which container has a metering valve having two relatively movable members for dispensing aerosol, the members being relatively movable to place the members of the valve in either a charging or a discharging position in relationship to the container. The dispensing includes a housing formed with a mouthpiece to which is connected an air passage. The aerosol container is releasably retained in the dispenser with the valve in communication with the mouthpiece and is mounted to allow relative movement between the members of the metering valve. A main spring is provided in the dispenser for biasing the members of the metering valve to their discharging position, and a charging apparatus mounted on the housing may counteract the spring to place said metering valve in the charging position. The metering valve may be releasably retained in the charging position by a latch mounted on the housing until an inhalation responsive device in the air passage is actuated by air flowing toward the mouthpiece to release the latch, and thus causing the spring to produce the discharge of a metered amount of aerosol from said container through the mouthpiece. The dispenser is actuated by the movement of a cover pivotally mounted on the housing between an open and a closed position through an actuator connected to the cover which activates the charging apparatus and the latch.

The foregoing advantages of the invention, together with various other advantages thereof which will be evident to those skilled in the inhalation responsive aerosol dispenser art in the light of this disclosure, may be achieved with the exemplary embodiment of the invention described in detail hereinafter and illustrated in the accompanying drawings wherein: Figure 1 is a longitudinal sectional view of an inhalation actuable aerosol dispenser which embodies the invention, showing the cover of the dispenser closed Figures 2 and 3 are sectional views respectively taken along the arrowed lines 2-2 and 3-3 of Figure 1; Figure 4 is a sectional view taken along the arrowed line 4-4 of Figure 2; Figure 5 is a sectional view taken along the arrowed line 5-5 of Figure 4; Figure 6 is a view similar to Figure 4, but showing the cover of the dispenser open and the dispenser ready for use; Figure 7 is a view similar to Figure 6, but showing the dispenser of the invention after it has been used to discharge a metered amount of medicament; Figure 8 is a view similar to Figure 7> but showing the cover in the process of being closed to again make the dispenser ready for use; Figure is a fragmentary view duplicating a portion of Figure 8 and showing various parts in the positions they occupy just before the dispenser is completely made read for use; Figure 10 is an exploded perspective view showing the parts of a charging means and a latch means of the dispenser of the invention; Figure 11 is a perspective view of a partition forming part of the housing of the dispenser; and Figure 12 is a perspective view of an inhalation actuable vane forming part of the dispenser.

Throughout the drawings , the dispenser of the invention is designated generally by the numeral 20 and includes a housing 22 having therein a compartment 24 for an aerosol medicament-dispensing device 26 comprising a container 28 charged with a self-propelling liquid composition including as one component thereof any desired medicament suitable for inhalation therapy.

The aerosol container 28 is slidable upwardly and downwardly in a guideway 30 in a member 32 disposed in the compartment 24 and releasably secured therein by a suitable latch 34 . The container 28 is provided at its lower end with a metering valve 36 engageable with a seat 38 communicating through a passage 40 with a mouthpiece 42 forming part of the member 32 . As best shown in Figure 7 > the mouthpiece 42 forms the terminus of an air passage, designated generally by the numeral 44 , through the housing 22 , the inlet 46 of the air passage 44 being adjacent the latch 34.

The metering valve 36 includes a housing member 48 within the container 28. Reciprocable in the housing 48 is a metering valve member 50 having a tubular stem 52 which projects from the housing 48 and the container 28 into the seat 38 through an annular seal 54. A lateral port 56 in the tubular stem 52 communicates with the interior of this stem 52 . V/hen the container 28 is in its upper position, Figure 6 , the metering valve member 5° is in its charging position and the port 56 is located axially outwardly of the annular seal 54. When the container 28 is moved downwardly into the position of Figure 7 , as will be described hereinafter , the metering valve member 50 is in its dis charging position and the port 56 is axially inwardly of the annular seal 4.

The metering valve member 50 is biased axially outwardly toward its charging position , shown in Figure 6 , by an auxiliary biasing member comprising a compress ion coil spring 8 seated at one end against an external collar on the metering valve member 0 and at its other end agains t the housing member 48. The metering va lve member 50 includes an axially-inwardly-extending pin 60 carrying a collar 62 which is engageable with an annular seal 64 , when the metering valve is in its dis charging position , Figure 7, to close a passage 66 interconnecting the interior of the housing 48 and the interior of the container 28. When the container 28 is in the position corresponding to t he charging pos ition , Figure 6 , of the metering valve 36 , the collar 62 disengages the annular seal 64 to open the passage 66.

Cons idering the operation of the metering valve 36 briefly , when the container 28 is in the pos ition corres -r ponding to the charging position of the metering valve member 0 , as shown in Figure 6 , a metered charge may flow from the interior of the container 28 into the hous ing 48 through the passage 66. Upon subsequent movement of the container 28 into the discharging position of the metering valve member 50 , as shown in Figure 7 , the metered charge is dis charged from the interior of the housing 48 through the port 56 and the tubular stem 52 , into the passage 40 leadin g to c -the mouthpiece 42. Under such circumstances, the collar 62 closes the passage 66 to prevent further flow from the interior of the container 28. Conversely, when the metering valve member 5° was in its charging position, Figure 6 , the port 56 was located axially outwardly of the annular seal 5 to disconnect the tubular stem 52 from the interior of the housing 48.

The compression coil spring 8 forming part of the metering valve 36 biases the aerosol container 28 upwardly into its Figure 6 position, corresponding to the charging position of the metering valve 36. However, a main spring assembly 70 is capable of overcoming the spring 8 to. displace the container 28 downwardly into its Figure 7 position, corresponding to the discharging position of the metering valve member 50. The main spring assembly 70 comprises a relatively heavy coil spring 72 acting in compression between the upper end wall of the housing 22 and a driver 74 movable upwardly and downwardly along tracks 76, Figure 3. The driver 7 transmits the force of the spring 72 to the upper, closed end of the aerosol container 28 to bias it downwardly into its discharing position, Figure 7.

The dispenser 20 includes charging apparatus 80 for placing the aerosol dispensing device 26 in its charging condition in opposition to the action of the spring 72 , which biases it toward its discharging condition. More particularly, the charging apparatus 80 opposes the action of the spring 72 to enable the spring 58 of the metering valve 36 to displace the container upwardly away from its seat 38 into a position corresponding to the charging posi-tion of the metering valve member 50 , Figure 6.

The charging apparatus 80 includes an L-shaped charging lever 82 having its shorter arm pivotally connected to the housing 22 at 84. The charging lever 82 extends through an aperture 86 in the driver 7 and is engageable with a knife edge 88 forming the upper edge of the aperture. As will be apparent , when the charging lever 82 is pivoted upwardly, it acts through the driver 74 to compress the spring 72 and permit the spring 58 in the metering valve 36 to displace the container 28 upwardly into the position thereof corresponding to the charging position of the metering valve member 50. The manner in which the charging lever 82 is pivoted upwardly will be considered hereinafter.

Alongside the compartment 24 for the aerosol dispensing device 26 , and separated therefrom by a partition 90, are an actuator compartment 92 and a vane compartment 94, Figure 5. The actuator and vane compartments 92 and 94 are separated by an irregular partition 96 , shown in perspective in Figure 11 .

As will be clear from Figure 7> the lower end of the vane compartment 94 forms a part of the air passage 44 leading to the mouthpiece 42. The vane compartment contains an inhalation responsive device 98 which, as will be described hereinafter, permits the aerosol dispensing means 26 to. deliver a metered charge to the mouthpiece 42 for inhala-tion by the user of the dispenser 20.

More particularly, the inhalation actuable device 98 includes a depending vane 100 disposed in and closely fitting the vane compartment 94. The vane 100 is provided at its upper end with a pivot shaft 102 suitably pivotally mounted in the housing 22 so that the vane 100 can swing back and forth in the vane compartment 9 between a latching position, Figure 6, and a latch-releasing position, Figure 7. The pivot shaft 102 is provided thereon within the actuator compartment 92 with a flat 104 for a purpose to be described. It will be apparent that, when the patient inhales through the mouthpiece 42, the flow of air through the passage 44, as shown in Figure 7, pivots the vane 100 from its latching position to its latch-releasing position.

The dispenser 20 further includes a latch assembly 110 in the actuator compartment 92 for releasably retaining the aerosol dispensing device 26 in its charging condition, the latch assembly 110 being releasable by the inhalation responsive device 98 to permit the main spring assembly 70 to place the aerosol container 28 in its discharging condition, whereby it discharges a metered amount into the stream of air being inhaled by the patient through the mouthpiece 42. Considering the latch assembly 110 more specifically, it includes a generally upright latch 112 having at its lower end a pivot shaft 114 seated in a semi-cylindrical bearing 116 carried by the partition 96 and one sidewall of the housing 22. The latch 112 is provided at its upper end with a hook ll8 and is rotatable between a first position at which the hook ll8 is separated from the vane pivot shaft 102 (Figure 7) to a second position at which the hook ll8 is in contact with the vane pivot shaft 102 (Figures 3, 4 and 6). The hook ll8 is adapted to hook over the flatted portion of the vane pivot shaft 102, as shown in Figure 6, when the vane 100 is in its latching position.

When the vane 100 is pivoted into its latch-releasing position, Figure 6, by the user8s inhalation, the vane pivot shaft 102 is rotated sufficiently to permit an end 120 of the hook ll8 to slide across the flat 104 to release the latch assembly 110. Conversely, as shown in Figure 9, the hook end 120 may slide across the flat 104 in engaging the latch 112 with the vane pivot shaft 102, prior to pivoting the vane 100 into its latching position.

The latch 112 and the charging lever 82 are inter-connected within the actuator compartment 92 by a link 124 pivotally connected to the latch 112 intermediate its ends at 126 and to the charging lever 82 at its free end, at 128. The relationship between the link 124, the charging lever 82 and the latch 112 is such that as the latch is hooked over the vane pivot shaft 102, Figure 6, the charging lever 82 is also pivoted upwardly into a position corresponding to the charging position of the metering valve 36. Thus, the latch assembly 110 releasably retains the charging apparatus 80 in a position corresponding to the charging position of the metering valve 36. The charging apparatus 80 and the latch assembly 110 are placed in their foregoing locked positions by an actuator 130 in the actuator compartment 92, such actuator also serving to place the vane 100 in its latching position so that the hook ll8 of the latch 112 is hooked over the flatted portion of the vane pivot, shaft 102.

Considering the actuator 130 in more detail, it is pivotally connected at 132 to a cover 134 for the mouthpiece 42. The cover 134 is pivotally connected to the housing 22, at 136, for pivotal movement between a closed position, Figures 1 to 5 and an open position, Figures 6 and 7.

The actuator 130 comprises a bifurcated cam 139 which extends upwardly from the cover 134 into the actuator compartment 92 and which terminates in a first cam segment 140, and a second cam segment 142. The cam segment l Q , as best shown in Figures 7 and 8, engages a pin 144 on the latch 112 to pivot the latch 112 from its first position to its second position and into latching engagement with the vane pivot shaft 102, as will be apparent by considering Figures 8, 9 and 4 in that order. This occurs, as will be evident from the drawings, in response to closing movement of the cover 134. At the same time, the link 124 acts on the charging lever 82 to pivot it upwardly into a position corresponding to the charging position of the metering valve 36. While these events are taking place, the cam segment l42 engages an arm 146 on the vane pivot shaft 102, as shown in Figure 9, to pivot the vane 100 into its latching position, Figure 4. The cam segment 142 pivots the vane 100 into its latching position as the end 120 of the hook ll8 moves across the flat 104 on the vane pivot shaft 102. Consequently, as the vane 100 is displaced into its latching position, the flatted portion of the vane pivot shaft 102 is rotated into hooked relation with the latch hook ll8, as shown in Figure 4, and also in Figure 6. As further shown in Figure 6, once the latch 112 has entered into hooked engagement with the flatted portion of the vane pivot shaft 102, the cover 134 may be opened to disengage the cam segments 140 and 142 from the latch 112 and the vane 100. < Referring particularly to Figure , the cam segment 142 is provided thereon with a projection 148 which is engageable with one edge of the semi-cylindrical bearing ll6 to releasably retain the actuator 130 in a position to hold the cover 13 closed. Upon opening the cover 13 manually, the projection 148 disengages the bearing 116 .

It will be assumed initially that the various parts of the dispenser 20 are in the positions shown in Figure 4 of the drawings, wherein the dispenser is cocked with the aerosol dispensing device 26 in its charging condition. More particularly, the latch assembly 110 retains the charging apparatus 80 in a position corresponding to the charging position of the metering valve 36 , and also retains the vane 100 in its latching position. Further, the cover 134 is closed to maintain the cam segments l40 and 142 respectively in engagement with the pin l44 on the latch 112 and the arm 146 on the vane pivot shaft 102.

When the dispenser 20 is to be used, the cover 134 is opened, as shown in Figure 6 . This makes the mouthpiece 42 accessible, and also disengages the cam segments 140 and 142 from the latch pin 144 and from the vane-pivot-shaft arm 146 , respectively.

Next, the patient places the mouthpiece 42 in his mouth and inhales therethrough, thereby causing air to flow through the passage 44, as shown- in Figure 7. This air flow causes the vane 100 to pivot into its latch-releasing position, as shown in Figure 7. Very little flow is required to accomplish this since the only thing preventing movement of the vane 100 from its latching position to its latch-releasing position is friction between the hook ll8 and the vane pivot shaft 102 and friction between the vane pivot shaft and its bearings . Pivoting of the vane 100 toward its latch-releasing position aljgns or registers the flat 104 on the vane pivot shaft 102 with the hook end 120, whereby the hook ll8 may disengage the vane pivot shaft 102, under the impetus provided by the main spring 72. The latter,acting through the driver 74, propels the aerosol container 28 into a position corresponding to the discharging position of the metering valve 36. Thus, a metered charge is delivered to the mouthpiece 42 for inhalation by the user in the same breath used to trigger the dispenser 20. In other words, the act of inhaling results in substan-tially simultaneous triggering of the dispenser 20 and inhalation of the metered charge dispensed thereby.

Subsequently, the cover 134 is returned to its closed position, thereby causing the various parts to move from the positions shown in Figure through the positions shown in Figures 8 and 9 back to those shown in Figure 4. This readies the dispenser 20 for subsequent reuse when necessary.

Although an exemplary embodiment of the invention has been disclosed for purposes of illustration, it will be understood that the various changes, modifications and substitutions may be incorporated in such embodiment.

Claims (5)

1. 400,282 What we claim is: 1. inhalation actuable dispenser for with an aerosol container/ having a metering valve; for dispensing aerosol from said container, said metering valve having two members which are relatively movable between a chaigjn and a discharging position of said metering valve, said dispenser having: a housing formed with a mouthpiece and an air passage therethrough, said air passage terminating at said mouthpiece; said housing further being formed with: a compartment for receiving said aerosol container to allow relative movement between' said members of said metering valve and for providing communication between said metering valve and said mouthpiece; a spring for biasing said members of said metering valve to said discharging position; a charging apparatus mounted on said housing for providing relative movement of said members of said metering valve to place said metering valve in said charging position in opposition to the action of said spring; . a latch mounted on said housing for releasably retaining said metering valve in its charging position; and inhalation responsive device in said air passage, and actuable by air flowing therethrough toward said mouthpiece, for releasing said latch to cause said spring to produce relative movement between said members of said metering valve to place said metering yal e^ in a discharging position whereby said metering valve discharges a metered amount from said container through said mouthpiece, wherein said. dispenser further includes : a cover for said mouthpiece pivots lly mounted on said housing for movement between an open and a closed position; and an actuator connected to said cover and responsive to movement thereof between said open and said closed position for activating said charging apparatus and said latch.

2. An inhalation actuated dispenser according to claim 1 wherein: said metering valve includes a valve spring to urge one of said members of said metering valve outward of said container toward said charging position of said metering valve; said mounting means includes a seat for said outwardly urged member of said metering valve, said seat being formed with a passage for conveying a discharge from said metering valve to said mouthpiece; said spring for biasing said movable members to said discharge positions is mounted between said container and said housing to bias said container carrying said outwardly urged member of said metering valve toward said seat and said discharge position of said metering valve in opposition to said valve spring; and said inhalation responsive device includes a vane movably mounted in said housing, said vane being posi- tioned in said air passage and being movable in response to air flowing to said mouthpiece from a latching position for retaining said latch in a position for retaining said metering valve in its charging position to a releasing position for releasing said latch.

3. An inhalation actuated dispenser according to claim 1 or claim 2 wherein said actuator for activating said charging apparatus and said latch is responsive to movement of said cover from said open to said closed position.

4. An inhalation actuated dispenser according to claim 2 or claim 3 wherein: said vane has at one end a pivot shaft formed with a flat thereon, said shaft being journaled in said housing and being pivotal with said vane between said latching and said releasing position; and said latch is pivotally mounted on said housing for movement between a first and a second position and includes a hook engageable with said pivot shaft at said second position of said latch, said hook having an end slidable across said flat to release said latch when said vane is in said releasing position, 5„ An inhalation actuable dispenser according to claim 4 wherein said actuator is positioned for pivoting said pivot shaft when said latch is in said second position to engage said hook with said pivot shaft with said end of said hook out of register with said flat upon movement of said cover between said open and said closed position. 6. An inhalation actuable dispenser according to claim 2 wherein: said vane is mounted for pivotal movement between said latching position and said latch releasing position; and said actuator is positioned for pivoting said vane into said latching position upon movement of said cover between said open and said closed position. 7. An inhalation actuated dispenser according to claim 4 wherein said charging apparatus includes a charging lever pivotally mounted at one end on said housing, the other end of said lever being connected to said latch, said charging lever being connected intermediate its ends to said spring, said lever being movable to afford movement of said metering valve between said discharging and said charging position in response to said latch being moved between said first and said second position. 8. An inhalation actuable dispenser as defined in claim 7 wherein said actuator includes a cam engageable with said latch to move said latch from said first to said second position, and engageable with said vane to move said vane from said unlatching to said latching position upon said latch reaching said second position in response to the movement of said cover from said open to said closed position. 9. An inhalation actuable dispenser according to any preceding claim wherein said actuator includes a projection releasably engageable with said housing for latching said cover in its closed position. 10. An inhalation actuable dispenser having: a housing formed with a mouthpiece and an air passage therethrough, said air passage terminating at said mouthpiece; aerosol dispensing device mounted in said housing and communicating with said mouthpiece for dispensing predetermined amounts of aerosol through said mouthpiece, members of said dispensing device being relatively movable between a charging and a discharging position; a spring for biasing said movable members of said dispensing device to said discharging position; £la charging apparatus mounted on said housing for affording movement of said relatively movable members of said dispensing device to said charging position in opposition to the action of said spring; a latch mounted on said housing for releasably retaining said dispensing device in its charging position; and inhalation responsive device in said air passage, and actuable by air flowing therethrough toward said mouthpiece, for releasing said latch so that said spring produces relative movement between said members of said dispensing device to place said dispensing means in a discharging position whereby said dispensing device discharges a metered amount of aerosol through said mouthpiece, wherein said dispenser further includes: a cover for said mouthpiece pivotally mounted on said housing for movement between an open and a closed position; and an actuator connected to said cover and responsive to movement thereof between said open and said closed position for activating said charging apparatus and said latch. 11= An inhalation actuable dispenser according to claim 10 wherein said aerosol dispensing device includes an aerosol container and an aerosol metering valve communicating with said container, said valve having members relatively movable between said charging and said discharging position. 12. An inhalation actuable dispenser according to claim 11 wherein said metering valve is mounted on said container, and said container is removably and movably mounted on said housing to allow relative movement between said members of said metering valve and to provide communication between said metering valve and said mouthpiece. 13. An inhalation actuable dispenser according to claim 12 wherein: said metering valve includes a valve spring to urge one of said members of said metering valve outward of said container toward said charing position of said metering valve ; said housing includes a seat for said outwardly urged member of said metering valve, said seat being formed with a passage for conveying a discharge from said metering valve to said mouthpiece; said spring for biasing said movable members to said discharge position is mounted between said container and said housing to bias said container carrying said outwardly urged member of said metering valve toward said seat and said discharge position of said metering valve in opposition to said valve spring; and said inhalation responsive device includes a vane movably mounted in said housing, said vane being positioned in said air passage and being movable in response to air flowing to said mouthpiece from a latching position for retaining said latch in a position for retaining said metering valve in its charging position to a releasing position for releasing said latch. 14. An inhalation actuated dispenser according to claim 10 or claim 13 wherein said actuator for activating said charging apparatus and said latch is responsive to movement of said cover from said open to said closed position. 1

5. An inhalation actuated dispenser according to claim 13 or claim l wherein: said vane has at one end a pivot shaft formed with a flat thereon, said shaft being journaled in said housing and being pivotable with said vane between said latching and said releasing position; and said latch is pivotally mounted on said housing i'oi" movement between a first and a second position and includes a hook engageable with said pivot shaft at said second position of said latch, said hook having an end slidable across said flat to release said latch when said vane is in said releasing position. ΐβ. An inhalation actuable dispenser according to claim 15 wherein said actuator is positioned for pivoting said pivot shaft into a position to engage said hook with said pivot shaft with said end of said hook out of register with said flat upon movement of said cover between said open and said closed position. 17. An inhalation actuable dispenser accordin to claim 13 wherein: said vane is mounted for pivotal' movement between said latching position and said latch releasing position; and said actuator is positioned for pivoting said vane into said latching position upon movement of said cover between said open and said closed position. 18 „ An inhalation actuable dispenser according to claim 15 wherein said charging apparatus includes a charging lever pivotally mounted at one end on said housing, the other end of said lever being connected to said latch, said charging lever being connected intermediate its ends to said spring, said lever being movable to afford movement of said metering valve between said discharging and said charging position in response to said latch being moved between said first and said second position. 19 An inhalation actuable dispenser as defined in claim 18 wherein said actuator includes a cam engageable with said latch to move said latch from said first to said second position, and engageable with said vane to move said vane from said unlatching to said latching position upon said latch reaching said second position in response to the movement of said cover from said open to said closed position. 20. An inhalation actuable dispenser according to any preceding claim wherein said actuator includes a projection releasably engageable with said housing for latching said cover in its closed position. 21. An inhalation actuable dispenser substantially as hereinbefore described ompanying drawings. Attorneys for Applicant