US20220151236A1 - Novel oxadiazole compounds for controlling or preventing phytopathogenic fungi - Google Patents

Novel oxadiazole compounds for controlling or preventing phytopathogenic fungi Download PDF

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Publication number
US20220151236A1
US20220151236A1 US17/594,215 US202017594215A US2022151236A1 US 20220151236 A1 US20220151236 A1 US 20220151236A1 US 202017594215 A US202017594215 A US 202017594215A US 2022151236 A1 US2022151236 A1 US 2022151236A1
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Prior art keywords
methyl
imidazo
oxadiazol
trifluoromethyl
pyridin
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Inventor
Paras Raybhan Bhujade
Maruti N. Naik
Nitin Ramesh Tembhare
Santosh Shridhar Autkar
Ruchi Garg
Vishwanath GADE
Alexander G.M. Klausener
Visannagari Ramakrishna
Sonali SWARNKAR
Vinod Sunil WAGHMARE
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PI Industries Ltd
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PI Industries Ltd
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Assigned to PI INDUSTRIES LTD. reassignment PI INDUSTRIES LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: TEMBHARE, Nitin Ramesh, GADE, Vishwanath, KLAUSENER, Alexander G.M., AUTKAR, Santosh Shridhar, NAIK, MARUTI N., RAMAKRISHNA, Visannagari, SWARNKAR, Sonali, BHUJADE, Paras Raybhan, GARG, Ruchi, WAGHMARE, Vinod Sunil
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Definitions

  • the present invention relates to novel oxadiazole compounds useful for combating phytopathogenic fungi, a combination thereof and to a composition comprising novel oxadiazole compounds.
  • the present invention also relates to a method for controlling or preventing phytopathogenic fungi.
  • Oxadiazoles have already been disclosed in the literature. For example in JPS5665881, JPS63162680, JPS6296480, JPS6051188, WO2005051932, EP3165093, EP3167716, EP3165093, WO2017076740, WO2017102006, WO2017110861, WO2017110862, WO2017110864, WO2017157962, WO2017174158, WO2017198852, WO2017207757, WO2017211650, WO2017211652, WO2017220485, WO2017072247, WO2017076742, WO2017076757, WO2017076935, WO2018015447, WO2018065414, WO2018118781, WO2018187553 and WO2018202491 various oxadiazoles have been disclosed.
  • oxadiazole compounds reported in the above literature have disadvantages in certain aspects, such as that they exhibit a narrow spectrum of application or that they do not have satisfactory fungicidal activity, particularly at low application rates.
  • This objective is achieved by using a compound of formula (I) of the present invention for controlling or preventing phytopathogenic fungi.
  • the present invention relates to a compound of formula (I),
  • R 1 , L 1 , A, k, R 8 , R 9 , L 2 and R 8 are as defined in the detailed description.
  • the present invention also relates to a process for preparing the compound of formula (I).
  • the present invention further relates to a combination comprising the compound of formula (I) of the present invention and at least one further pesticidally active substance for effectively controlling or preventing phytopathogenic fungi which are difficult to combat.
  • the present invention still further relates to a composition
  • a composition comprising the compound of formula (I) or the compound of formula (I) in combination with a further pesticidally active substance.
  • the present invention still further relates to a method and use of the compound of formula (I), the combination or the composition thereof for controlling and or preventing plant diseases, particularly phtopathogenic fungi.
  • compositions comprising, “comprising”, “includes”, “including”, “has”, “having”, “contains”, “containing”, “characterized by” or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated.
  • a composition, mixture, process or method that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process or method.
  • transitional phrase “consisting essentially of” is used to define a composition or method that includes materials, steps, features, components or elements, in addition to those literally disclosed, provided that these additional materials, steps, features, components or elements do not materially affect the basic and novel characteristic(s) of the claimed invention.
  • the term “consisting essentially of” occupies a middle ground between “comprising” and “consisting of”.
  • “or” refers to an inclusive “or” and not to an exclusive “or”.
  • a condition A “or” B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present).
  • the term “invertebrate pest” includes arthropods, gastropods and nematodes of economic importance as pests.
  • arthropod includes insects, mites, spiders, scorpions, centipedes, millipedes, pill bugs and symphylans.
  • gastropod includes snails, slugs and other Stylommatophora.
  • nematode refers to a living organism of the Phylum Nematoda.
  • helminths includes roundworms, heartworms, phytophagous nematodes (Nematoda), flukes (Tematoda), acanthocephala and tapeworms (Cestoda).
  • invertebrate pest control means inhibition of invertebrate pest development (including mortality, feeding reduction, and/or mating disruption), and related expressions are defined analogously.
  • agronomic refers to the production of field crops such as for food, feed and fiber and includes the growth of corn, soybeans and other legumes, rice, cereal (e.g., wheat, oats, barley, rye, rice, maize), leafy vegetables (e.g., lettuce, cabbage, and other cole crops), fruiting vegetables (e.g., tomatoes, pepper, eggplant, crucifers and cucurbits), potatoes, sweet potatoes, grapes, cotton, tree fruits (e.g., pome, stone and citrus), small fruit (berries, cherries) and other specialty crops (e.g., canola, sunflower, olives).
  • wheat e.g., wheat, oats, barley, rye, rice, maize
  • leafy vegetables e.g., lettuce, cabbage, and other cole crops
  • fruiting vegetables e.g., tomatoes, pepper, eggplant, crucifers and cucurbits
  • potatoes e.g., sweet potatoes, grapes, cotton, tree fruits (e.
  • nonagronomic refers to other than field crops, such as horticultural crops (e.g., greenhouse, nursery or ornamental plants not grown in a field), residential, agricultural, commercial and industrial structures, turf (e.g., sod farm, pasture, golf course, lawn, sports field, etc.), wood products, stored product, agro-forestry and vegetation management, public health (i.e. human) and animal health (e.g., domesticated animals such as pets, livestock and poultry, undomesticated animals such as wildlife) applications.
  • horticultural crops e.g., greenhouse, nursery or ornamental plants not grown in a field
  • turf e.g., sod farm, pasture, golf course, lawn, sports field, etc.
  • wood products e.g., stored product, agro-forestry and vegetation management
  • public health i.e. human
  • animal health e.g., domesticated animals such as pets, livestock and poultry, undomesticated animals such as wildlife
  • Nonagronomic applications include protecting an animal from an invertebrate parasitic pest by administering a parasiticidally effective (i.e. biologically effective) amount of a compound of the present invention, typically in the form of a composition formulated for veterinary use, to the animal to be protected.
  • a parasiticidally effective (i.e. biologically effective) amount of a compound of the present invention typically in the form of a composition formulated for veterinary use, to the animal to be protected.
  • parasiticidal i.e. biologically effective
  • Parasiticidally refers to observable effects on an invertebrate parasite pest to provide protection of an animal from the pest. Parasiticidal effects typically relate to diminishing the occurrence or activity of the target invertebrate parasitic pest.
  • Such effects on the pest include necrosis, death, retarded growth, diminished mobility or lessened ability to remain on or in the host animal, reduced feeding and inhibition of reproduction.
  • These effects on invertebrate parasite pests provide control (including prevention, reduction or elimination) of parasitic infestation or infection of the animal.
  • Stereoisomers of the present disclosure may be present either in pure form or as mixtures of different possible isomeric forms such as stereoisomers or constitutional isomers.
  • the various stereoisomers include enantiomers, diastereomers, chiral isomers, atropisomers, conformers, rotamers, tautomers, optical isomers, polymorphs, and geometric isomers. Any desired mixtures of these isomers fall within the scope of the claims of the present disclosure.
  • one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other isomer(s) or when separated from the other isomer(s). Additionally, the person skilled in the art knows processes or methods or technology to separate, enrich, and/or to selectively prepare said isomers.
  • alkyl used either alone or in compound words such as “alkylthio” or “haloalkyl” or N(alkyl) or alkylcarbonylalkyl or alkylsuphonylamino includes straight-chain or branched C 1 to C 24 alkyl, preferably C 1 to C 15 alkyl, more preferably C 1 to C 10 alkyl, most preferably C 1 to C 6 alkyl.
  • alkyl examples include methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2 methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropy
  • the alkyl is at the end of a composite substituent, as, for example, in alkylcycloalkyl
  • the part of the composite substituent at the start for example the cycloalkyl
  • other radicals for example alkenyl, alkynyl, hydroxyl, halogen, carbonyl, carbonyloxy and the like, are at the end.
  • alkenyl used either alone or in compound words includes straight-chain or branched C 2 to C 24 alkenes, preferably C 2 to C 15 alkenes, more preferably C 2 to C 10 alkenes, most preferably C 2 to C 6 alkenes.
  • Non-limiting examples of alkenes include ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1-butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-1-propenyl, 1-ethyl-2-propen
  • Alkenyl also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. This definition also applies to alkenyl as a part of a composite substituent, for example haloalkenyl and the like, unless defined specifically elsewhere.
  • Non-limiting examples of alkynes include ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentyny
  • alkynyl as a part of a composite substituent, for example haloalkynyl etc., unless specifically defined elsewhere.
  • alkynyl can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl.
  • cycloalkyl means alkyl closed to form a ring. Non-limiting examples include cyclopropyl, cyclopentyl and cyclohexyl. This definition also applies to cycloalkyl as a part of a composite substituent, for example cycloalkylalkyl etc., unless specifically defined elsewhere.
  • cycloalkenyl means alkenyl closed to form a ring including monocyclic, partially unsaturated hydrocarbyl groups. Non-limiting examples include cyclopropenyl, cyclopentenyl and cyclohexenyl. This definition also applies to cycloalkenyl as a part of a composite substituent, for example cycloalkenylalkyl etc., unless specifically defined elsewhere.
  • cycloalkynyl means alkynyl closed to form a ring including monocyclic, partially unsaturated groups. Non-limiting examples include cyclopropynyl, cyclopentynyl and cyclohexynyl. This definition also applies to cycloalkynyl as a part of a composite substituent, for example cycloalkynylalkyl etc., unless specifically defined elsewhere.
  • cycloalkoxy cycloalkenyloxy
  • cycloalkoxy cycloalkenyloxy
  • Non limiting examples of cycloalkoxy include cyclopropyloxy, cyclopentyloxy and cyclohexyloxy. This definition also applies to cycloalkoxy as a part of a composite substituent, for example cycloalkoxy alkyl etc., unless specifically defined elsewhere.
  • halogen either alone or in compound words such as “haloalkyl”, includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as “haloalkyl”, said alkyl may be partially or fully substituted with halogen atoms which may be the same or different.
  • haloalkyl include chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 1,1-dichloro-2,2,2-trifluoroethyl, and 1,1,1-trifluoroprop-2-yl. This definition also applies to haloalkyl as a part
  • haloalkenyl haloalkynyl
  • alkenyl and alkynyl groups are present as a part of the substituent.
  • haloalkoxy means straight-chain or branched alkoxy groups where some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as specified above.
  • Non-limiting examples of haloalkoxy include chloromethoxy, bromomethoxy, dichloromethoxy, trichloromethoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, chlorofluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 1-chloroethoxy, 1-bromoethoxy, 1-fluoroethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2-trichloroethoxy, pentafluoroethoxy and 1,1,1-
  • haloalkylthio means straight-chain or branched alkylthio groups where some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as specified above.
  • Non-limiting examples of haloalkylthio include chloromethylthio, bromomethylthio, dichloromethylthio, trichloromethylthio, fluoromethylthio, difluoromethylthio, trifluoromethylthio, chlorofluoromethylthio, dichlorofluoromethylthio, chlorodifluoromethylthio, 1-chloroethylthio, 1-bromoethylthio, 1-fluoroethylthio, 2-fluoroethylthio, 2,2-difluoroethylthio, 2,2,2-trifluoroethylthio, 2-chloro-2-fluoroethylthio, 2-chloro-2,2-difluoroethylthio,
  • Non-limiting examples of “haloalkylsulfinyl” include CF 3 S(O), CCl 3 S(O), CF 3 CH 2 S(O) and CF 3 CF 2 S(O).
  • Non-limiting examples of “haloalkylsulfonyl” include CF 3 S(O) 2 , CCl 3 S(O) 2 , CF 3 CH 2 S(O) 2 and CF 3 CF 2 S(O) 2 .
  • hydroxy means —OH
  • Amino means —NRR, wherein R can be H or any possible substituent such as alkyl.
  • Carbonyl means —C( ⁇ O)—
  • carbonyloxy means —OC( ⁇ O)—
  • sulfinyl means SO
  • sulfonyl means S(O) 2 .
  • alkoxy used either alone or in compound words included C 1 to C 24 alkoxy, preferably C 1 to C 15 alkoxy, more preferably C 1 to C 10 alkoxy, most preferably C 1 to C 6 alkoxy.
  • alkoxy include methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1-dimethylethoxy, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy,
  • alkoxyalkyl denotes alkoxy substitution on alkyl.
  • alkoxyalkyl include CH 3 OCH 2 , CH 3 OCH 2 CH 2 , CH 3 CH 2 OCH 2 , CH 3 CH 2 CH 2 CH 2 OCH 2 and CH 3 CH 2 OCH 2 CH 2 .
  • alkoxyalkoxy denotes alkoxy substitution on alkoxy.
  • alkylthio includes branched or straight-chain alkylthio moieties such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio, 1,1-dimethylethylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2-dimethylpropylthio, 1-ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1-methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1,3-dimethylbutylthio, 2,2-dimethylbutylthio
  • Halocycloalkyl, halocycloalkenyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, haloalkylcarbonyl, cycloalkylcarbonyl, haloalkoxylalkyl, and the like, are defined analogously to the above examples.
  • alkylthioalkyl denotes alkylthio substitution on alkyl.
  • alkylthioalkyl include —CH 2 SCH 2 , —CH 2 SCH 2 CH 2 , CH 3 CH 2 SCH 2 , CH 3 CH 2 CH 2 CH 2 SCH 2 and CH 3 CH 2 SCH 2 CH 2 .
  • Alkylthioalkoxy denotes alkylthio substitution on alkoxy.
  • cycloalkylalkylamino denotes cycloalkyl substitution on alkyl amino.
  • alkoxyalkoxyalkyl “alkylaminoalkyl”, “dialkylaminoalkyl”, “cycloalkylaminoalkyl”, “cycloalkylaminocarbonyl” and the like, are defined analogously to “alkylthioalkyl” or “cycloalkylalkylamino”.
  • alkoxycarbonyl is an alkoxy group bonded to a skeleton via a carbonyl group (—CO—). This definition also applies to alkoxycarbonyl as a part of a composite substituent, for example cycloalkylalkoxycarbonyl and the like, unless specifically defined elsewhere.
  • alkoxycarbonylalkylamino denotes alkoxy carbonyl substitution on alkyl amino.
  • Alkylcarbonylalkylamino denotes alkyl carbonyl substitution on alkyl amino.
  • alkylthioalkoxycarbonyl, cycloalkylalkylaminoalkyl and the like are defined analogously.
  • alkylsulfinyl include methylsulphinyl, ethylsulphinyl, propylsulphinyl, 1-methylethylsulphinyl, butylsulphinyl, 1-methylpropylsulphinyl, 2-methylpropylsulphinyl, 1,1-dimethylethylsulphinyl, pentylsulphinyl, 1-methylbutylsulphinyl, 2-methylbutylsulphinyl, 3-methylbutylsulphinyl, 2,2-dimethylpropylsulphinyl, 1-ethylpropylsulphinyl, hexylsulphinyl, 1,1-dimethylpropylsulphinyl, 1,2-dimethylpropylsulphinyl, 1-methylpentylsulphinyl, 2-methylpentylsulphinyl, 3-methylpentylsulphinyl, 4-methylpentylsulphiny
  • arylsulfinyl includes Ar—S(O), wherein Ar can be any carbocycle or heterocycle. This definition also applies to alkylsulphinyl as a part of a composite substituent, for example haloalkylsulphinyl etc., unless specifically defined elsewhere.
  • alkylsulfonyl include methylsulphonyl, ethylsulphonyl, propylsulphonyl, 1-methylethylsulphonyl, butylsulphonyl, 1-methylpropylsulphonyl, 2-methylpropylsulphonyl, 1,1-dimethylethylsulphonyl, pentylsulphonyl, 1-methylbutylsulphonyl, 2-methylbutylsulphonyl, 3-methylbutylsulphonyl, 2,2-dimethylpropylsulphonyl, 1-ethylpropylsulphonyl, hexylsulphonyl, 1,1-dimethylpropylsulphonyl, 1,2-dimethylpropylsulphonyl, 1-methylpentylsulphonyl, 2-methylpentylsulphonyl, 3-methylpentylsulphonyl, 4-methylpentylsulphony
  • arylsulfonyl includes Ar—S(O) 2 , wherein Ar can be any carbocycle or heterocycle. This definition also applies to alkylsulphonyl as a part of a composite substituent, for example alkylsulphonylalkyl etc., unless defined elsewhere.
  • Alkylamino “dialkylamino”, and the like, are defined analogously to the above examples.
  • carrier or carbocyclic includes “aromatic carbocyclic ring system” and “non-aromatic carbocylic ring system” or polycyclic or bicyclic (spiro, fused, bridged, nonfused) ring compounds in which ring may be aromatic or non-aromatic (where aromatic indicates that the Huckel rule is satisfied and non-aromatic indicates that the Huckel rule is not satisfied).
  • heterocycle or heterocyclic includes “aromatic heterocycle or heteroaryl ring system” and “non-aromatic heterocycle ring system” or polycyclic or bicyclic (spiro, fused, bridged, nonfused) ring compounds in which ring may be aromatic or non-aromatic, wherein the heterocycle ring contains at least one heteroatom selected from N, O, S(O)O 2 , and or C ring member of the heterocycle may be replaced by C( ⁇ O), C( ⁇ S), C( ⁇ CR*R*) and C ⁇ NR*, * indicates integers.
  • non-aromatic heterocycle or “non-aromatic heterocyclic” means three- to fifteen-membered, preferably three- to twelve-membered, saturated or partially unsaturated heterocycle containing one to four heteroatoms from the group of oxygen, nitrogen and sulphur: mono, bi- or tricyclic heterocycles which contain, in addition to carbon ring members, one to three nitrogen atoms and/or one oxygen or sulphur atom or one or two oxygen and/or sulphur atoms; if the ring contains more than one oxygen atom, they are not directly adjacent; non-limiting examples oxetanyl, oxiranyl, aziridinyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3-tetrahydrothienyl, 1 pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-isoxazolidinyl, 4-isox
  • heteroaryl or “aromatic heterocyclic” means 5 or 6-membered, fully unsaturated monocyclic ring system containing one to four heteroatoms from the group of oxygen, nitrogen and sulphur; if the ring contains more than one oxygen atom, they are not directly adjacent; 5-membered heteroaryl containing one to four nitrogen atoms or one to three nitrogen atoms and one sulphur or oxygen atom; 5-membered heteroaryl groups which, in addition to carbon atoms, may contain one to four nitrogen atoms or one to three nitrogen atoms and one sulphur or oxygen atom as ring members, non-limiting examples furyl, thienyl, pyrrolyl, isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, thiazolyl, imidazolyl, 1,2,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1,2,4-triazolyl, 1,3,4-ox
  • 6-membered heteroaryl which contains one to four nitrogen atoms: 6-membered heteroaryl groups which, in addition to carbon atoms, may contain, respectively, one to three and one to four nitrogen atoms as ring members, non-limiting examples 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl, 1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl and 1,2,4,5-tetrazin-3-yl; benzofused 5-membered heteroaryl containing one to three nitrogen atoms or one nitrogen atom and one oxygen or sulphur atom: non-limiting examples indol-1-yl, indol-2-yl, indol-3-yl, indol-4-yl, indol-5-yl, indol-6
  • trialkylsilyl includes 3 branched and/or straight-chain alkyl radicals attached to and linked through a silicon atom such as trimethylsilyl, triethylsilyl and t-butyl-dimethylsilyl.
  • “Halotrialkylsilyl” denotes at least one of the three alkyl radicals is partially or fully substituted with halogen atoms which may be the same or different.
  • alkoxytrialkylsilyl denotes at least one of the three alkyl radicals is substituted with one or more alkoxy radicals which may be the same or different.
  • trialkylsilyloxy denotes a trialkylsilyl moiety attached through oxygen.
  • alkylcarbonyl examples include C( ⁇ O)CH 3 , C( ⁇ O)CH 2 CH 2 CH 3 and C( ⁇ O)CH(CH 3 ) 2 .
  • alkoxycarbonyl examples include CH 3 OC( ⁇ O), CH 3 CH 2 OC( ⁇ O), CH 3 CH 2 CH 2 OC( ⁇ O), (CH 3 ) 2 CHOC( ⁇ O) and the different butoxy - or pentoxycarbonyl isomers.
  • alkylaminocarbonyl examples include CH 3 NHC( ⁇ O), CH 3 CH 2 NHC( ⁇ O), CH 3 CH 2 CH 2 NHC( ⁇ O), (CH 3 ) 2 CHNHC( ⁇ O) and the different butylamino - or pentylaminocarbonyl isomers.
  • dialkylaminocarbonyl examples include (CH 3 ) 2 NC( ⁇ O), (CH 3 CH 2 ) 2 NC( ⁇ O), CH 3 CH 2 (CH 3 )NC( ⁇ O), CH 3 CH 2 CH 2 (CH 3 )NC( ⁇ O) and (CH 3 ) 2 CHN(CH 3 )C( ⁇ O).
  • alkoxyalkylcarbonyl include CH 3 OCH 2 C( ⁇ O), CH 3 OCH 2 CH 2 C( ⁇ O), CH 3 CH 2 OCH 2 C( ⁇ O), CH 3 CH 2 CH 2 CH 2 OCH 2 C( ⁇ O) and CH 3 CH 2 OCH 2 CH 2 C( ⁇ O).
  • alkylthioalkylcarbonyl include CH 3 SCH 2 C( ⁇ O), CH 3 SCH 2 CH 2 C( ⁇ O), CH 3 CH 2 SCH 2 C( ⁇ O), CH 3 CH 2 CH 2 CH 2 SCH 2 C( ⁇ O) and CH 3 CH 2 SCH 2 CH 2 C( ⁇ O).
  • haloalkylsufonylaminocarbonyl alkylsulfonylaminocarbonyl, alkylthioalkoxycarbonyl, alkoxycarbonylalkyl amino and the like are defined analogously
  • alkylaminoalkylcarbonyl include CH 3 NHCH 2 C( ⁇ O), CH 3 NHCH 2 CH 2 C( ⁇ O), CH 3 CH 2 NHCH 2 C( ⁇ O), CH 3 CH 2 CH 2 CH 2 NHCH 2 C( ⁇ O) and CH 3 CH 2 NHCH 2 CH 2 C( ⁇ O).
  • amide means A-R′C ⁇ ONR′′—B, wherein R 1 and R′′ indicates substituents and A and B indicate any group.
  • thioamide means A-R′C ⁇ SNR′′—B, wherein R′ and R′′ indicates substituents and A and B indicate any group.
  • C i -C j The total number of carbon atoms in a substituent group is indicated by the “C i -C j ” prefix where i and j are numbers from 1 to 21.
  • C 1 -C 3 alkylsulfonyl designates methylsulfonyl through propylsulfonyl
  • C 2 alkoxyalkyl designates CH 3 OCH 2
  • C 3 alkoxyalkyl designates, for example, CH 3 CH(OCH 3 ), CH 3 OCH 2 CH 2 or CH 3 CH 2 OCH 2
  • C 4 alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH 3 CH 2 CH 2 OCH 2 and CH 3 CH 2 OCH 2 CH 2 .
  • all substituents are attached to these rings through any available carbon or nitrogen by replacement of a hydrogen on said
  • inventive compound of the present invention may, if appropriate, be present as mixtures of different possible isomeric forms, especially of stereoisomers, for example E and Z, threo and erythro, and also optical isomers, but if appropriate also of tautomers. Both the E and the Z isomers, and also the threo and erythro isomers, and the optical isomers, any desired mixtures of these isomers and the possible tautomeric forms are disclosed and claimed.
  • pest for the purpose of the present disclosure includes but is not limited to fungi, stramenopiles (oomycetes), bacteria, nematodes, mites, ticks, insects and rodents.
  • Plant is understood here to mean all plants and plant populations, such as desired and undesired wild plants or crop plants (including naturally occurring crop plants).
  • Crop plants may be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the transgenic plants and including the plant cultivars which are protectable and non-protectable by plant breeders' rights.
  • plant includes a living organism of the kind exemplified by trees, shrubs, herbs, grasses, ferns, and mosses, typically growing in a site, absorbing water and required substances through its roots, and synthesizing nutrients in its leaves by photosynthesis.
  • plants for the purpose of the present invention include but are not limited to agricultural crops such as wheat, rye, barley, triticale, oats or rice; beet, e.g. sugar beet or fodder beet; fruits and fruit trees, such as pomes, stone fruits or soft fruits, e.g.
  • leguminous plants such as lentils, peas, alfalfa or soybeans; oil plants, such as rape, mustard, olives, sunflowers, coconut, cocoa beans, castor oil plants, oil palms, ground nuts or soybeans; cucurbits, such as squashes, cucumber or melons; fiber plants, such as cotton, flax, hemp or jute; citrus fruit and citrus trees, such as oranges, lemons, grapefruits or mandarins; any horticultural plants, vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceous plants, such as avocados, cinnamon or camphor; cucurbitaceae ; oleaginous plants; energy and raw material plants, such as cereals, corn, soybean, other leguminous plants, rape, sugar cane or oil palm; tobacco; nuts; coffee; tea
  • the plant for the purpose of the present invention includes but is not limited to cereals, corn, rice, soybean and other leguminous plants, fruits and fruit trees, grapes, nuts and nut trees, citrus and citrus trees, any horticultural plants, cucurbitaceae , oleaginous plants, tobacco, coffee, tea, cacao, sugar beet, sugar cane, cotton, potato, tomato, onions, peppers and vegetables, ornamentals, any floricultural plants and other plants for use of human and animals.
  • plant parts is understood to mean all parts and organs of plants above and below the ground.
  • plant parts includes but is not limited to cuttings, leaves, twigs, tubers, flowers, seeds, branches, roots including taproots, lateral roots, root hairs, root apex, root cap, rhizomes, slips, shoots, fruits, fruit bodies, bark, stem, buds, auxillary buds, meristems, nodes and internodes.
  • locus thereof includes soil, surroundings of plant or plant parts and equipment or tools used before, during or after sowing/planting a plant or a plant part.
  • compositions optionally comprising other compatible compounds to a plant or a plant material or locus thereof include application by a technique known to a person skilled in the art which include but is not limited to spraying, coating, dipping, fumigating, impregnating, injecting and dusting.
  • adhered means adhered to a plant or plant part either physically or chemically including impregnation.
  • R 1 is C 1 -C 2 -haloalkyl
  • L 1 is a direct bond, —CR 2 R 3 —, —C( ⁇ W 1 )—, —CR 2 R 3 C( ⁇ W 1 )—, —O—, —S( ⁇ O) 0-2 —, or —NR 4a —; wherein, the expression “-” at the start and the end of the group indicates the point of attachment to either oxadiazole ring or A;
  • A is a fused heterobicyclic ring having N at one or more bridgehead; wherein said ring is optionally substituted with one or more identical or different groups of R A ;
  • L 2 is a direct bond or is selected from the group consisting of —C( ⁇ O)—, —C( ⁇ S)—, —O—, —S( ⁇ O) 0-2 —, —NR 10 —,
  • R 8 and R 9 are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, C 1 -C 6 -alkylthio, C 3 -C 8 -cycloalkenyl, phenyl-C 1 -C 6 -alkyl, heteroaryl-C 1 -C 6 -alkyl, phenyl, naphthyl and a 3- to 10-membered saturated, partially unsaturated or aromatic mono- or bicyclic carbocyclic ring or heterocyclic ring, wherein the ring members of the heteroaryl of the heteroaryl-C 1 -C 6 -alkyl and the heterocyclic ring include C, N, O and S
  • R 5 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -haloalkynyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -halocycloalkyl, C 1 -C 6 -alkyl-C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkyl-C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl-C 3 -C 8 -cycloalkyl, C 3 -C 8 -halocycloalkyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkyl-C 3 -C 8 -
  • R 6 and R 13 are independently selected from the group consisting of hydrogen, halogen, hydroxy, cyano, nitro, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -haloalkynyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -halocycloalkyl, C 1 -C 6 -alkyl-C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkyl C 1 -C 6 alkyl, C 3 -C 8 -cycloalkyl-C 3 -C 8 -cycloalkyl, C 3 -C 8 -halocycloalkyl-C 1 -C 6 -alkyl, C 1 -C
  • the present invention provides a compound of formula (I), wherein
  • R 1 selected from the group consisting of CF 3 , CHF 2 , CF 2 C 1 , CF 2 CF 3 CH 2 F, CH 2 CF 3 , CHClCF 3 and CCl 2 CF 3 ;
  • L 1 is a direct bond, —CR 2 R 3 —;
  • A is a fused heterobicyclic ring having N at one or more bridgehead; wherein said ring is optionally substituted with one or more identical or different groups of R A ,
  • R 8 and R 9 are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl and C 1 -C 6 -alkylthio; or
  • R 8 and R 9 together with the atoms to which they are bound form C( ⁇ O) or a vinyl group or a saturated, monocyclic 3- to 7-membered heterocyclic ring or carbocyclic ring, wherein the ring members of heterocyclic include C, N, O and S(O) 0-2 ; and wherein the vinyl group, the heterocyclic ring or the carbocyclic ring is unsubstituted or substituted with one or more identical or different R 8b , wherein R 8b is selected from the group consisting of halogen, cyano, nitro, hydroxyl, sulfanyl, amino, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio and C 3 -C 8 -cycloal
  • the present invention provides a compound of formula (I), wherein
  • R 1 selected from the group consisting of CF 3 , CHF 2 , CF 2 C 1 , CHClCF 3 and CCl 2 CF 3 ;
  • L 1 is a direct bond
  • R 8 and R 9 are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl and C 3 -C 8 -cycloalkyl; or
  • R 8 and R 9 together with the atoms to which they are bound form C( ⁇ O) or a vinyl group.
  • the compound of formula (I) is selected from N-(3-methoxyphenyl)-7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carboxamide; N-(4-methoxyphenyl)-7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carboxamide; N-(p-tolyl)-7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carboxamide; N-(3-fluorophenyl)-7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carboxamide; N-(2,4-difluorophenyl)-7-(5-(trifluoromethyl)-1,2,4
  • the compound of the present invention can exist as one or more stereoisomers.
  • the various stereoisomers include enantiomers, diastereomers, atropisomers and geometric isomers.
  • one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers.
  • the compound of the present invention may be present as a mixture of stereoisomers, individual stereoisomers or as an optically active form.
  • An anion part of the salt in case the compound of formula I is a cationic or capable of forming a cation can be inorganic or organic.
  • a cation part of the salt in case the compound of formula (I) is an anionic or capable of forming anion can be inorganic or organic.
  • inorganic anion part of the salt include but are not limited to chloride, bromide, iodide, fluoride, sulfate, phosphate, nitrate, nitrite, hydrogen carbonates and hydrogen sulfate.
  • organic anion part of the salt examples include but are not limited to formate, alkanoates, carbonates, acetates, trifluoroacetate, trichloroacetate, propionate, glycolate, thiocyanate, lactate, succinate, malate, citrates, benzoates, cinnamates, oxalates, alkylsulphates, alkylsulphonates, arylsulphonates aryldisulphonates, alkylphosphonates, arylphosphonates, aryldiphosphonates, p-toluenesulphonate, and salicylate.
  • inorganic cation part of the salt examples include but are not limited to alkali and alkaline earth metals.
  • organic cation part of the salt examples include but are not limited to pyridine, methyl amine, imidazole, benzimidazole, hitidine, phosphazene, tetramethyl ammonium, tetrabutylammonium, choline and trimethylamine.
  • Metal ions in metal complexes of the compound of formula (I) are especially the ions of the elements of the second main group, especially calcium and magnesium, of the third and fourth main group, especially aluminium, tin and lead, and also of the first to eighth transition groups, especially chromium, manganese, iron, cobalt, nickel, copper, zinc and others. Particular preference is given to the metal ions of the elements of the fourth period and the first to eighth transition groups.
  • the metals can be present in the various valencies that they can assume.
  • the compound selected from formula (I), typically may exist in more than one form.
  • Formula I thus includes all crystalline and non-crystalline forms of the compound that formula (I) represents.
  • Non-crystalline forms include embodiments which are solids such as waxes and gums as well as embodiments which are liquids such as solutions and melts.
  • Crystalline forms include embodiments which represent essentially a single crystal type and embodiments which represent a mixture of polymorphs (i.e. different crystalline types).
  • polymorph refers to a particular crystalline form of a chemical compound that can crystallize in different crystalline forms, these forms having different arrangements and/or conformations of the molecules in the crystal lattice.
  • polymorphs can have the same chemical composition, they can also differ in composition due to the presence or absence of co-crystallized water or other molecules, which can be weakly or strongly bound in the lattice. Polymorphs can differ in such chemical, physical and biological properties as crystal shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspensibility, dissolution rate and biological availability.
  • a polymorph of a compound represented by formula (I) can exhibit beneficial effects (e.g., suitability for preparation of useful formulations, improved biological performance) relative to another polymorph or a mixture of polymorphs of the same compound represented by formula (I).
  • Preparation and isolation of a particular polymorph of a compound represented by formula (I) can be achieved by methods known to those skilled in the art including, for example, crystallization using selected solvents and temperatures.
  • the present invention provides a process for the preparation of compound of formula (I).
  • the present invention provides a process for the preparation of the compound of formula (I) comprising the steps of:
  • L 1 is direct bond; A is
  • R 1 , k, R 8 , R 9 , L 2 and R 5 are as defined in the above detailed description.
  • the present invention provides a process for the preparation of the compound of formula (I) comprising the steps of:
  • L 1 is direct bond; A is
  • R 1 , k, R 8 , R 9 and R 5 are as defined in the above detailed description.
  • the present invention provides a process for the preparation of compound of formula (I) comprising the steps of:
  • L 1 is direct bond; A is
  • L 2 is —S( ⁇ O) 0-2 —; R 1 , k, R 8 , R 9 and R 5 are as defined in the above detailed description.
  • the present invention provides a process for the preparation of compound of formula (I) comprising the steps of:
  • L 1 is direct bond; A is
  • Y is —NR 10 and L 3 is C( ⁇ O)—;
  • R 1 , k, R 8 , R 9 and R 5 are as defined in the above detailed description.
  • the present invention provides a process for the preparation of compound of formula (I) comprising the steps of:
  • L 1 is direct bond; A is
  • R 1 , k, R 8 , R 9 and R 5 are as defined in the above detailed description.
  • the compounds of the present invention as defined by general formula (I) and/or in tables 1 to 12 may be prepared, in known manner, in a variety of ways as described in the schemes 1-5.
  • L 1 is direct bond; A is
  • R 1 , k, R 8 , R 9 and R 5 are as defined in the above detailed description.
  • the compound of formula ii can be prepared by reacting 2-amino pyridine compound of formula i and alpha-halo carbonyl compound of formula v in the presence of polar protic solvents such as ethanol optionally in the presence of acid such as acetic acid at refluxing temperatures.
  • polar protic solvents such as ethanol
  • acid such as acetic acid
  • the compound of formula iii can be prepared by reacting compound of formula ii with hydroxyl amine in the presence of polar protic solvents such as ethanol, methanol etc. at ambient temperature to 60° C. This reaction can also be done in solvents such as tetrahydrofuran, 1,4-dioxane etc.
  • the compound of formula iv can be prepared by reacting the compound of formula iii with acid anhydride of formula (d) optionally in the presence of organic bases such as triethylamine or N,N-diisopropylethylamine.
  • the compound of formula iii can be reacted with acid chloride compound of formula (e) optionally in the presence of organic bases such as triethyl amine, N,N-diisopropylethyl amine etc. to obtain desired compound of formula iv.
  • this reaction is carried out in aprotic solvents such as tetrahydrofuran, 1,4-dioxane, dichloromethane, etc. at temperatures from 0-60° C.
  • ester compound of formula iv and sulphoximine compound of formula (a) can be obtained by reacting the ester compound of formula iv and sulphoximine compound of formula (a) by using trimethyl aluminium as coupling reagent. This reaction can be carried out in solvents such as toluene, tetrahydrofuran or 1,4-dioxane at 0-110° C.
  • the compounds of formula (I) can also be prepared by using a process as depicted in scheme 2:
  • L 1 is direct bond; A is
  • R 1 , k, R 8 , R 9 and R 5 are as defined in the above detailed description.
  • the compound of formula vi can be obtained by reacting the compound of formula i and compound of formula ix optionally in the presence of organic acid such as acetic acid. This reaction can be carried out in solvents such as tetrahydrofuran or 1,4-dioxane at temperature 25° C. to refluxing temperature.
  • the compound of formula vii can be obtained by reacting compound of formula vi with hydroxylamine in aprotic solvents such as tetrahydrofuran, 1,4-dioxane, etc. at 0-60° C.
  • aprotic solvents such as tetrahydrofuran, 1,4-dioxane, etc. at 0-60° C.
  • the compound of formula viii can be prepared by reacting compound of formula vi and acid anhydride of formula (d) optionally in the presence of bases such as triethyl amine, diisopropyl ethyl amine etc.
  • the compound of formula vii can be reacted with acid chloride compound of formula (e) optionally in the presence of organic bases such as triethyl amine, diisopropylethyl amine, etc. to obtain desired compound of formula vii.
  • this reaction is carried out in aprotic solvents such as tetrahydrofuran, 1,4-dioxane, dichloromethane, etc. at temperatures from 0-60° C.
  • amid coupling reagents such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (in the presence of 4-dimethylaminopyridine), 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU), etc. in solvents such as dichloromethane, tetrahydrofuran, dimethyl formamide etc. This reaction can be carried out at 0-60° C.
  • the compounds of formula (I) can also be prepared by using a process as depicted in scheme 3:
  • L 1 is direct bond; A is
  • L 2 is —S( ⁇ O) 0-2 —; R 1 , k, R 8 , R 9 and R 5 are as defined in the above detailed description.
  • the compound of formula xi can be obtained by reacting compound of formula i with compound of formula x in polar protic solvents such as ethanol, methanol, etc.
  • the compound of formula xii can be obtained by reacting compound of formula xi with hydroxyl amine in solvents such as ethanol, methanol etc. This reaction can be carried out at temperature 0-60° C.
  • the compound of formula xiii can be obtained by cyclizing compound of formula xii with acid anhydride of formula (d) or acid chloride of formula (e) in solvents such as tetrahydrofuran, dichloromethane or 1,4-dioxane. This reaction can be carried out at temperature 0-60° C. optionally in the presence of organic bases such as triethyl amine or diisopropyl ethyl amine.
  • the compound of formula xiv can be obtained by reacting compound of formula xiii and thiol compound of formula (f) in the presence of bases such as potassium carbonate, cesium carbonate. This reaction can be carried out in solvents such as acetonitrile, N,N-dimethylformamide, dimethyl sulphoxide etc.
  • the compound of formula I wherein L 2 is —S( ⁇ O) 0-2 — can be obtained by oxidation of sulphide compound of formula xiv by using appropriate equivalents of oxidizing agent such as oxone, m-chloroperbenzoic acid. This reaction can be carried out in solvents such as dichloromethane at temperature 0° C. to 35° C.
  • the compounds of formula (I) can be prepared by using a process as depicted in scheme 4:
  • L 1 is direct bond; A is
  • Y is —NR 10 and L 3 is —C( ⁇ O)—;
  • R 1 , k, R 8 , R 9 and R 5 are as defined in the above detailed description.
  • Azide compound of formula xv can be obtained by reacting compound of formula xii and alkali metal azides such as sodium azide, potassium azide, etc. in polar aprotic solvents such as N,N-dimethyl formamide, dimethyl sulphoxide, etc. This reaction can be carried out at temperatures 0-60° C.
  • Amine compound of formula xvi can be synthesized by reacting azide compound of formula xv by staudinger reaction condition in the presence of triphenylphosphine and water. This reaction can be carried out in solvents such as tetrahydrofuran.
  • Y is —NR 10 and L 3 is —C( ⁇ O)—
  • Y is —NR 10 and L 3 is —C( ⁇ O)—
  • a suitable coupling reagents such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide-hydroxybenzotriazole or 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphateetc. in the presence of organic bases such as triethyl amine or diisopropyl ethyl amine.
  • the compound of formula (I) can also be obtained by reacting amine compound of formula xvi with carboxylic acid chloride of formulac in the presence of organic bases such as triethylamine or diisopropylethyl amine or pyridine etc.
  • the compounds of formula (I) can be prepared by using a process as depicted in scheme 5:
  • L 1 is direct bond; A is
  • R 1 , k, R 8 , R 9 and R 5 are as defined in the above detailed description.
  • the compound of formula xvii can be prepared by reducing the compound of formula iv with a suitable reducing reagent such as diisobutylaluminum hydride (DIBAL-H). This reaction can be carried out in solvents such as dichloromethane, tetrahydrofuran etc. at temperature ⁇ 78° C. to ⁇ 50° C.
  • DIBAL-H diisobutylaluminum hydride
  • the compound of formula xviii can be prepared by oxidation of dihydro-oxadiazole compound of formula xvii by using a suitable oxidizing reagent 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in solvents such as dichloromethane at 0° C. to 35° C.
  • the present invention provides a compound of formula (B);
  • L 1 is direct bond
  • R 8 and R 9 are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl and C 3 -C 8 -cycloalkyl;
  • k is an integer ranging from 0 and 1;
  • R is selected from the group consisting of hydrogen, azide, halogen, hydroxy, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 3 -C 8 -cycloalkyl, amino-C 1 -C 6 -alkyl, di-C 1 -C 6 -alkylamino, NHSO 2 —C 1 -C 6 -alkyl, —S( ⁇ O)( ⁇ NH)—C 1 -C 6 -alkyl; —C( ⁇ O)—C 1 -C 6 -alkyl, C( ⁇ O)—C 1 -C 6 -alkoxy, C 1 -C 6 -alkylsulfonyl, hydroxy-C 1 -C 6
  • the compound of formula (B) is selected from 7-(N′-hydroxycarbamimidoyl)imidazo[1,2-a]pyridine-2-carboxylic acid, ethyl 2-(7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2-yl)acetate, 7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carboxylic acid, 7-(5-(trifluoromethyl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carbaldehyde, 7-(5-(trifluoromethyl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carbaldehyde, 2-(chloromethyl
  • the present invention relates to a composition
  • a composition comprising the compound of formula (I), agriculturally acceptable salts, metal complexes, constitutional isomers, stereo-isomers, diastereoisomers, enantiomers, chiral isomers, atropisomers, conformers, rotamers, tautomers, optical isomers, polymorphs, geometric isomers, or N-oxides thereof optionally with one or more additional active ingredient with the auxiliary such as inert carrier or any other essential ingredient such as surfactants, additives, solid diluents and liquid diluents.
  • auxiliary such as inert carrier or any other essential ingredient such as surfactants, additives, solid diluents and liquid diluents.
  • the compound of Formula I and the composition according to the invention, respectively, are suitable as fungicides. They are distinguished by an outstanding effectiveness against a broad spectrum of phytopathogenic fungi, including soil-borne fungi, which derive especially from the classes of the Plasmodiophoromycetes, Peronosporomycetes (syn. Oomycetes), Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes (syn. Fungi imperfecti). Some are systemically effective and they can be used in crop protection as foliar fungicides, fungicides for seed dressing and soil fungicides. Moreover, they are suitable for controlling harmful fungi, which inter alia occur in wood or roots of plants.
  • the compound of Formula I and the composition according to the invention are particularly important in the control of a multitude of phytopathogenic fungi on various cultivated plants, such as cereals, e. g. wheat, rye, barley, triticale, oats or rice; beet, e. g. sugar beet or fodder beet; fruits, such as pomes, stone fruits or soft fruits, e. g.
  • cereals e. g. wheat, rye, barley, triticale, oats or rice
  • beet e. g. sugar beet or fodder beet
  • fruits such as pomes, stone fruits or soft fruits, e. g.
  • the compound of Formula I and the composition according to the invention are important in the control of phytopathogenic fungi on soybeans and on the plant propagation material, such as seeds, and the crop material of soybeans.
  • the present invention also includes a composition comprising at least one compound of Formula I and seed.
  • the amount of the compound of Formula I in the composition ranges from 0.1 gai (gram per active ingredient) to 10 kgai (kilogram per active ingredient) per 100 kg of seeds.
  • the compound of formula (I) and composition thereof, respectively are used for controlling a multitude of fungi on field crops, such as potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar cane; fruits; vines; ornamentals; or vegetables, such as cucumbers, tomatoes, beans or squashes.
  • field crops such as potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar cane; fruits; vines; ornamentals; or vegetables, such as cucumbers, tomatoes, beans or squashes.
  • plant propagation material is to be understood to denote all the generative or reproductive parts of the plant such as seeds and vegetative plant material such as cuttings and tubers (e. g. potatoes), which can be used for the multiplication of the plant. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, sprouts, twigs, flowers, and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil.
  • These young plants may also be protected before transplantation by a total or partial treatment by immersion or pouring.
  • treatment of plant propagation materials with the compound of Formula I, the combination and or the composition thereof, respectively is used for controlling a multitude of fungi on cereals, such as wheat, rye, barley and oats; rice, corn, cotton and soybeans.
  • cultiva plants is to be understood as including plants which have been modified by breeding, mutagenesis or genetic engineering including but not limiting to agricultural biotech products on the market or in development (cf. http://cera-gmc.org/, see GM crop database therein).
  • Genetically modified plants are plants, which genetic material has been so modified by the use of recombinant DNA techniques that under natural circumstances cannot readily be obtained by cross breeding, mutations or natural recombination.
  • one or more genes have been integrated into the genetic material of a genetically modified plant in order to improve certain properties of the plant.
  • Such genetic modifications also include but are not limited to targeted post-translational modification of protein(s), oligo- or polypeptides e. g.
  • auxin herbicides such as dicamba or 2,4-D
  • bleacher herbicides such as hydroxylphenylpyruvate dioxygena
  • herbicides e. bromoxynil or ioxynil herbicides as a result of conventional methods of breeding or genetic engineering. Furthermore, plants have been made resistant to multiple classes of herbicides through multiple genetic modifications, such as resistance to both glyphosate and glufosinate or to both glyphosate and a herbicide from another class such as ALS inhibitors, HPPD inhibitors, auxin herbicides, or ACCase inhibitors.
  • These herbicide resistance technologies are e. g. described in Pest Managem. Sci. 61, 2005, 246; 61, 2005, 258; 61, 2005, 277; 61, 2005, 269; 61, 2005, 286; 64, 2008, 326; 64, 2008, 332; Weed Sci.
  • mutagenesis e.g. Clearfield® summer rape (Canola, BASF SE, Germany) being tolerant to imidazolinones, e. g. imazamox, or ExpressSun® sunflowers (DuPont, USA) being tolerant to sulfonyl ureas, e. g. tribenuron.
  • Bacillus plants capable to synthesize one or more insecticidal proteins, especially those known from the bacterial genus ( Bacillus ), by the use of recombinant DNA techniques are within the scope of the present invention.
  • the Bacillus are particularly from Bacillus thuringiensis , such as ⁇ -endotoxins, e. g. Cry1A(b), Cry1A(c), Cry1F, Cry1F(a2), Cry11A(b), Cry111A, Cry111B(b1) or Cry9c; vegetative insecticidal proteins (VIP), e. g. VIP1, VIP2, VIP3 or VIP3A; insecticidal proteins of bacteria colonizing nematodes, e. g.
  • VIP1, VIP2, VIP3 or VIP3A vegetative insecticidal proteins of bacteria colonizing nematodes
  • Photorhabdus spp. or Xenorhabdus spp. toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins, or other insect-specific neurotoxins; toxins produced by fungi, such Streptomycetes toxins, plant lectins, such as pea or barley lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin or papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid-IDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors or HMG-CoA-reductase; ion channel blockers, such
  • these insecticidal proteins or toxins are to be understood expressly also as pre-toxins, hybrid proteins, truncated or otherwise modified proteins.
  • Hybrid proteins are characterized by a new combination of protein domains, (see, e. g. wO02/015701).
  • Further examples of such toxins or genetically modified plants capable of synthesizing such toxins are disclosed, e. g., in EP374753, WO93/007278, WO95/34656, EP427 529, EP451 878, WO03/18810 and WO03/52073.
  • the methods for producing such genetically modified plants are generally known to the person skilled in the art and are described, e. g. in the publications mentioned above.
  • insecticidal proteins contained in the genetically modified plants impart to the plants producing these proteins tolerance to harmful pests from all taxonomic groups of arthropods, especially to beetles ( Coeloptera ), two-winged insects ( Diptera ), and moths ( Lepidoptera ) and to nematodes (Nematoda).
  • Genetically modified plants capable to synthesize one or more insecticidal proteins are, e.
  • WO 03/018810 MON 863 from Monsanto Europe S.A., Belgium (corn cultivars producing the Cry3Bb1 toxin), IPC 531 from Monsanto Europe S.A., Belgium (cotton cultivars producing a modified version of the Cry1Ac toxin) and 1507 from Pioneer Overseas Corporation, Belgium (corn cultivars producing the Cry1 F toxin and PAT enzyme).
  • plants capable to synthesize one or more proteins to increase the resistance or tolerance of those plants to bacterial, viral or fungal pathogens by the use of recombinant DNA techniques are also within the scope of the present invention.
  • proteins are the so-called “pathogenesis-related proteins” (PR proteins, see, e. g. EP392225), plant disease resistance genes (e. g. potato cultivars, which express resistance genes acting against Phytophthora infestans derived from the Mexican wild potato Solanum bulbocastanum ) or T4-lysozym (e. g. potato cultivars capable of synthesizing these proteins with increased resistance against bacteria such as Erwinia amylvora).
  • PR proteins pathogenesis-related proteins
  • plant disease resistance genes e. g. potato cultivars, which express resistance genes acting against Phytophthora infestans derived from the Mexican wild potato Solanum bulbocastanum
  • T4-lysozym e. g. potato cultivars capable of
  • plants capable to synthesize one or more proteins by the use of recombinant DNA techniques, to increase the productivity (e. g. bio mass production, grain yield, starch content, oil content or protein content), tolerance to drought, salinity or other growth-limiting environmental factors or tolerance to pests and fungal, bacterial or viral pathogens of those plants are within the scope of the present invention.
  • plants that contain a modified amount of substances of content or new substances of content by the use of recombinant DNA techniques, to improve human or animal nutrition, e. g. oil crops that produce health-promoting long-chain omega-3 fatty acids or unsaturated omega-9 fatty acids (e. g. Nexera® rape, DOW Agro Sciences, Canada) are also within the scope of the present invention.
  • plants that contain a modified amount of substances of content or new substances of content by the use of recombinant DNA techniques, to improve raw material production, e. g. potatoes that produce increased amounts of amylopectin (e. g. Amflora® potato, BASF SE, Germany) are also within the scope of the present invention.
  • potatoes that produce increased amounts of amylopectin e. g. Amflora® potato, BASF SE, Germany
  • the present invention also relates to a method for controlling or preventing infestation of plants by phytopathogenic micro-organisms in agricultural crops and or horticultural crops wherein an effective amount of at least one compound of Formula I or the combination of the present invention or the composition of the present invention, is applied to the seeds of plants.
  • the compound, the combination and the composition of the present invention can be used for controlling or preventing plant diseases.
  • the compound of Formula I, the combination and or the composition thereof, respectively, are particularly suitable for controlling the following plant diseases:
  • Albugo spp. (white rust) on ornamentals, vegetables (e. g. A. Candida ) and sunflowers (e. g. A. tragopogonis ); Altemaria spp. ( Alternaria leaf spot) on vegetables, rape ( A. brassicola or brassicae ), sugar beets ( A. tenuis ), fruits, rice, soybeans, potatoes (e. g. A. solani or A. alternata ), tomatoes (e. g. A. solani or A. alternata ) and wheat; Aphanomyces spp. on sugar beets and vegetables; Ascochyta spp. on cereals and vegetables, e. g. A.
  • tritici anthracnose
  • Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.), e. g. Southern leaf blight ( D. maydis ) or Northern leaf blight ( B. zeicola ) on corn, e. g. spot blotch ( C. sorokiniana ) on cereals and e. g. B. oryzae on rice and turfs
  • Blumeria (formerly Erysiphe ) graminis (powdery mildew) on cereals (e. g.
  • Botrytis cinerea (teleomorph: Botryotinia fuckeliana : grey mold) on fruits and berries (e. g. strawberries), vegetables (e. g. lettuce, carrots, celery and cabbages), rape, flowers, vines, forestry plants and wheat; Bremia lactucae (downy mildew) on lettuce; Ceratocystis (syn. Ophiostoma ) spp. (rot or wilt) on broad-leaved trees and evergreens, e. g. C. ulmi (Dutch elm disease) on elms; Cercospora spp. ( Cercospora leaf spots) on corn (e. g.
  • Gray leaf spot C. zeae - maydis ), rice, sugar beets (e. g. C. beticola ), sugar cane, vegetables, coffee, soybeans (e. g. C. sojina or C. kikuchii ) and rice; Cladosporium spp. on tomatoes (e. g. C. fulvum : leaf mold) and cereals, e. g. C. herbarum (black ear) on wheat; Claviceps purpurea (ergot) on cereals; Cochliobolus (anamorph: Helminthosporium of Bipolaris ) spp. (leaf spots) on corn ( C. carbonum ), cereals (e. g.
  • C. sativus anamorph: B. sorokiniana
  • rice e. g. C. miyabeanus , anamorph: H. oryzae
  • Colletotrichum teleomorph: Glomerella
  • spp. anthracnose on cotton (e. g. C. gossypii ), corn (e. g. C. graminicola : Anthracnose stalk rot), soft fruits, potatoes (e. g. C. coccodes : black dot), beans (e. g. C. lindemuthianum ) and soybeans (e. g. C. truncatum or C.
  • Corticium spp. e. g. C. sasakii (sheath blight) on rice; Corynespora cassiicola (leaf spots) on soybeans and ornamentals; Cycloconium spp., e. g. C. oleaginum on olive trees; Cylindrocarpon spp. (e. g. fruit tree canker or young vine decline, teleomorph: Nectria or Neonectria spp.) on fruit trees, vines (e. g. C.
  • liriodendri teleomorph: Neonectria liriodendri : Black Foot Disease) and ornamentals; Dematophora (teleomorph: Rosellinia ) necatrix (root and stem rot) on soybeans; Diaporthe spp., e. g. D. phaseolorum (damping off) on soybeans; Drechslera (syn. Helminthosporium , teleomorph: Pyrenophora ) spp. on corn, cereals, such as barley (e. g. D. teres , net blotch) and wheat (e. g. D. D.
  • tritici - repentis tritici - repentis : tan spot), rice and turf; Esca (dieback, apoplexy) on vines, caused by Formitiporia (syn. Phellinus ) punctata, F. mediterranea, Phaeomoniella chlamydospora (earlier Phaeoacremonium chlamydosporum ), Phaeoacremonium aleophilum and/or Botryosphaeria obtusa; Elsinoe spp. on pome fruits (£. pyri), soft fruits (£. veneta : anthracnose) and vines (£.
  • ampelina anthracnose
  • Entyloma oryzae leaf smut
  • Epicoccum spp. black mold
  • Erysiphe spp. potowdery mildew
  • sugar beets £. betae
  • vegetables e. g. E. pisi
  • cucurbits e. g. E. cichoracearum
  • cabbages e. g. E. cruciferarum
  • Eutypa lata Eutypa canker or dieback, anamorph: Cytosporina lata , syn.
  • Microsphaera diffusa (powdery mildew) on soybeans
  • Monilinia spp. e. g. M. laxa, M. fructicola and M. fructigena (bloom and twig blight, brown rot) on stone fruits and other rosaceous plants
  • Mycosphaerella spp. on cereals, bananas, soft fruits and ground nuts, such as e. g. M. graminicola (anamorph: Septoria tritici, Septoria blotch) on wheat or M. fijiensis (black Sigatoka disease) on bananas
  • Peronospora spp. downy mildew) on cabbage (e. g. P.
  • brassicae ), rape (e. g. P. parasitica ), onions (e. g. P. destructor ), tobacco ( P. tabacina ) and soybeans (e. g. P. manshurica ); Phakopsora pachyrhizi and P. meibomiae (soybean rust) on soybeans; Phialophora spp. e. g. on vines (e. g. P. tracheiphila and P. tetraspora ) and soybeans (e. g. P. gregata : stem rot); Phoma lingam (root and stem rot) on rape and cabbage and P.
  • rape e. g. P. parasitica
  • onions e. g. P. destructor
  • tobacco P. tabacina
  • soybeans e. g. P. manshurica
  • betae root rot, leaf spot and damping-off on sugar beets
  • Phomopsis spp. on sunflowers, vines (e. g. P. viticola : can and leaf spot)
  • soybeans e. g. stem rot: P. phaseoli , teleomorph: Diaporthe phaseolorum
  • Physoderma maydis brown spots
  • Phytophthora spp. wilt, root, leaf, fruit and stem root
  • various plants such as paprika and cucurbits (e. g. P. capsici ), soybeans (e. g. P. megasperma , syn. P. sojae ), soybeans, potatoes and tomatoes (e. g.
  • P. infestans late blight
  • broad-leaved trees e. g. P. ramorum : sudden oak death
  • Plasmodiophora brassicae club root
  • Plasmopara spp. e. g. P. viticola (grapevine downy mildew) on vines and P. halstedii on sunflowers
  • Podosphaera spp. powdery mildew) on rosaceous plants, hop, pome and soft fruits, e. g. P. leucotricha on apples
  • Polymyxa spp. e. g. on cereals, such as barley and wheat ( P.
  • Pseudocercosporella herpotrichoides eyespot, teleomorph: Tapesia yallundae ) on cereals, e. g. wheat or barley
  • Pseudoperonospora downy mildew
  • Pseudopezicula tracheiphila red fire disease or .rotbrenner', anamorph: Phialophora ) on vines
  • Puccinia spp. rusts
  • P. oryzae (teleomorph: Magnaporthe grisea , rice blast) on rice and P. grisea on turf and cereals; Pythium spp (damping-off) on turf, rice, corn, wheat, cotton, rape, sunflowers, soybeans, sugar beets, vegetables and various other plants (e. g. P. ultimum or P. aphanidermatum ); Ramularia spp., e. g. R. collo - cygni ( Ramularia leaf spots, Physiological leaf spots) on barley and R. beticola on sugar beets; Rhizoctonia spp.
  • R. solani root and stem rot
  • S. solani silk and stem rot
  • S. solani silk and stem rot
  • S. solani silk blight
  • rice or R. cerealis Rhizoctonia spring blight
  • Rhizopus stolonifer black mold, soft rot
  • strawberries carrots, cabbage, vines and tomatoes
  • Rhynchosporium secalis scald
  • Sarocladium oryzae and S. attenuatum sheath rot) on rice
  • Sclerotinia spp Sclerotinia spp.
  • seed rot or white mold on vegetables and field crops, such as rape, sunflowers (e. g. S. sclerotiorum ) and soybeans (e. g. S. rolfsii or S. sclerotiorum ); Septoria spp. on various plants, e. g. S. glycines (brown spot) on soybeans, S. tritici ( Septoria blotch) on wheat and S. (syn. Stagonospora ) nodorum ( Stagonospora blotch) on cereals; Uncinula (syn.
  • Erysiphe ) necator prowdery mildew, anamorph: Oidium tuckeri ) on vines
  • Setospaeria spp. leaf blight
  • corn e. g. S. turcicum , syn. Helminthosporium turcicum
  • turf e. g. S. turcicum , syn. Helminthosporium turcicum
  • Sphaerotheca fuliginea prowdery mildew
  • Spongospora subterranea powdery scab
  • the compound of Formula I, the combination or the composition thereof may be used to treat several fungal pathogens.
  • pathogens of fungal diseases which can be treated in accordance with the invention include:
  • Ustilaginales such as Ustilaginoidea virens, Ustilago nuda, Ustilago tritici, Ustilago zeae , rusts for example those caused by Pucciniales such as Cerotelium fici, Chrysomyxa arctostaphyli, Coleosporium ipomoeae, Hemileia vastatrix, Puccinia arachidis, Puccinia cacabata, Puccinia graminis, Puccinia recondita, Puccinia sorghi, Puccinia hordei, Puccinia striiformis f.sp. Hordei, Puccinia striiformis f.sp.
  • Pucciniales such as Cerotelium fici, Chrysomyxa arctostaphyli, Coleosporium ipomoeae, Hemileia vastatrix, Puccinia arachidis, Puccini
  • Secalis, Pucciniastrum coryli , or Uredinales such as Cronartium ribicola, Gymnosporangium juniperi - viginianae, Melampsora medusae, Phakopsora pachyrhizi, Phragmidium mucronatum, Physopella ampelosidis, Tranzschelia discolor and Uromyces viciae - fabae ; and other rots and diseases such as those caused by Cryptococcus spp., Exobasidium vexans, Marasmiellus inoderma, Mycena spp., Sphacelotheca reiliana, Typhula ishikariensis, Urocystis agropyri, ltersonilia perplexans, Corticium invisum, Laetisaria fuciformis, Waitea circinata, Rhizoctonia solani, Thanetephorus cucurmeris, Enty
  • diseases caused by rust disease pathogens for example Gymnosporangium species, for example Gymnosporangium sabinae; Hemileia species, for example Hemileia vastatrix; Phakopsora species, for example Phakopsorapachyrhizi or Phakopsora meibomiae; Puccinia species, for example Puccinia recondita, Puccinia graminis oder Puccinia striiformis; Uromyces species, for example Uromyces appendiculatus;
  • Cronartium ribicola White pine blister rust
  • Gymnosporangium juniperi - virginianae Cedar-apple rust
  • Hemileia vastatrix Coffee rust
  • Phakopsora meibomiae and P. pachyrhizi Soybean rust
  • Puccinia coronata Crown Rust of Oats and Ryegrass
  • Puccinia graminis Stetem rust of wheat and Kentucky bluegrass, or black rust of cereals
  • Puccinia hemerocallidis Daylily rust
  • Puccinia persistens subsp.
  • Puccinia sorghi rust in corn
  • Puccinia striiformis ‘Yellow rust’ in cereals
  • Uromyces appendiculatus rust of beans
  • Uromyces phaseoli Bean rust
  • Puccinia melanocephala ‘Brown rust’ in sugarcane
  • Puccinia kuehnii ‘Orange rust’ in sugarcane
  • Plants which can be treated in accordance with the invention include the following: cotton, flax, grapevine, fruits, vegetables, such as Rosaceae sp (for example pome fruits such as apples, pears, apricots, cherries, almonds and peaches), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for example banana trees and plantations), Rubiaceae sp.
  • Rosaceae sp for example pome fruits such as apples, pears, apricots, cherries, almonds and peaches
  • Ribesioidae sp. Juglandaceae sp.
  • Betulaceae sp. Ana
  • Theaceae sp. for example coffee
  • Theaceae sp. Sterculiceae sp.
  • Rutaceae sp. for example lemons, oranges and grapefruit
  • Vitaceae sp. for example grapes
  • Solanaceae sp. for example tomatoes, peppers
  • Liliaceae sp. for example lettuce
  • Umbelliferae sp. for example Cruciferae sp., Chenopodiaceae sp.
  • Cucurbitaceae sp. for example cucumber
  • Alliaceae sp. for example leek, onion
  • peas for example peas
  • major crop plants such as PoaceaelGramineae sp.
  • PoaceaelGramineae sp. for example maize, turf, cereals such as wheat, rye, rice, barley, oats, millet and triticale
  • Asteraceae sp. for example sunflower
  • Brassicaceae sp. for example white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, pak choi, kohlrabi, radishes, and oilseed rape, mustard, horseradish and cress
  • Fabacae sp. for example bean, peanuts
  • Papilionaceae sp. for example soya bean
  • Rhizoctonia solani sclerotinia stem decay ( Sclerotinia sclerotiorum ), sclerotinia southern blight ( Sclerotiuia rolfsii ), thielaviopsis root rot ( Thielaviopsis basicola ).
  • the present invention also relates to the use of the compound of Formula I, the combination or the composition thereof for controlling or preventing the following plant diseases: Puccinia spp. (rusts) on various plants, for example, but not limited to P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as e. g. wheat, barley or rye and Phakopsoraceae spp. on various plants, in particular Phakopsorapachyrhizi and P. meibomiae (soybean rust) on soybeans, Hemileia vastatrix (Coffee rust), Uromyces appendiculatus, Uromyces fabae and Uromyces phaseoli (rust of beans).
  • Puccinia spp.
  • the present invention further relates to the use of the compound of Formula I, the combination or the composition thereof for controlling or preventing against phytopathogenic fungi such as Phakopsora pachyrhizi, Phakopsora meibomiae , of agricultural crops and or horticultural crops.
  • the compound of formula (I), the combination and the composition thereof, respectively, are also suitable for controlling harmful fungi in the protection of stored products or harvest and in the protection of materials.
  • the term “protection of materials” is to be understood to denote the protection of technical and non-living materials, such as adhesives, glues, wood, paper and paperboard, textiles, leather, paint dispersions, plastics, cooling lubricants, fiber or fabrics, against the infestation and destruction by harmful microorganisms, such as fungi and bacteria.
  • Ascomycetes such as Ophiostoma spp., Ceratocystis spp., Aureobasidium pullulans, Sclerophoma spp., Chaetomium spp., Humicola spp., Petriella spp., Trichurus spp.; Basidiomycetes such as Coniophora spp., Coriolus spp., Gloeophyllum spp., Lentinus spp., Pleurotus spp., Pora spp., Serpula spp.
  • Ascomycetes such as Ophiostoma spp., Ceratocystis spp., Aureobasidium pullulans, Sclerophoma spp., Chaetomium spp., Humicola spp., Petriella spp., Trichurus spp.
  • Basidiomycetes such as Coniophora spp
  • yeast fungi are worthy of note: Candida spp. and Saccharomyces cerevisae.
  • the compound of Formula (I), the combination and the composition thereof, respectively are particularly suitable for controlling the following plant diseases: Phakopsora pachyrhizi and P. meibomiae (soybean rust) on soybeans.
  • the present invention further relates to a method for controlling or preventing phytopathogenic fungi.
  • the method comprises treating the fungi or the materials, plants, plant parts, locus thereof, soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of formula (I) or the combination or the composition comprising at least one compound of formula (I).
  • the method of treatment according to the invention can also be used in the field of protecting stored products or harvest against attack of fungi and microorganisms.
  • the term “stored products” is understood to denote natural substances of plant or animal origin and their processed forms, which have been taken from the natural life cycle and for which long-term protection is desired.
  • Stored products of crop plant origin such as plants or parts thereof, for example stalks, leafs, tubers, seeds, fruits or grains, can be protected in the freshly harvested state or in processed form, such as pre-dried, moistened, comminuted, ground, pressed or roasted, which process is also known as post-harvest treatment.
  • stored products are timber, whether in the form of crude timber, such as construction timber, electricity pylons and barriers, or in the form of finished articles, such as furniture or objects made from wood.
  • Stored products of animal origin are hides, leather, furs, hairs and the like.
  • the combination according the present invention can prevent disadvantageous effects such as decay, discoloration or mold.
  • stored products is understood to denote natural substances of plant origin and their processed forms, more preferably fruits and their processed forms, such as pomes, stone fruits, soft fruits and citrus fruits and their processed forms.
  • the compound of formula (I), the combination and the composition thereof, respectively, may be used for improving the health of a plant.
  • the invention also relates to a method for improving plant health by treating a plant, its propagation material and/or the locus where the plant is growing or is to grow with an effective amount of compound I and the composition thereof, respectively.
  • plant health is to be understood to denote a condition of the plant and/or its products which is determined by several indicators alone or in combination with each other such as yield (e. g. increased biomass and/or increased content of valuable ingredients), plant vigor (e. g. improved plant growth and/or greener leaves (“greening effect”)), quality (e. g. improved content or composition of certain ingredients) and tolerance to abiotic and/or biotic stress.
  • yield e. g. increased biomass and/or increased content of valuable ingredients
  • plant vigor e. g. improved plant growth and/or greener leaves (“greening effect”)
  • quality e. g. improved content or composition of certain ingredients
  • tolerance to abiotic and/or biotic stress e. g. improved content or composition of certain ingredients
  • the compound of formula (I) can be present in different crystal modifications or polymorphs whose biological activity may differ. They are likewise subject matter of the present invention.
  • the compound of formula (I) are employed as such or in the form of composition for treating the fungi or the plants, plant propagation materials, such as seeds, soil, surfaces, materials or rooms to be protected from fungal attack with a fungicidally effective amount of the active substances.
  • the application can be carried out both before and after the infection of the plants, plant propagation materials, such as seeds, soil, surfaces, materials or rooms by the fungi.
  • Plant propagation materials may be treated with the compound of formula (I), the combination and the composition thereof protectively either at or before planting or transplanting.
  • the invention also relates to agrochemical composition
  • agrochemical composition comprising an auxiliary and at least one compound of formula (I).
  • An agrochemical composition comprises a fungicidally effective amount of a compound of formula (I).
  • the term “effective amount” denotes an amount of the composition or of the compound of formula (I), which is sufficient for controlling harmful fungi on cultivated plants or in the protection of materials and which does not result in a substantial damage to the treated plants. Such an amount can vary in a broad range and is dependent on various factors, such as the fungal species to be controlled, the treated cultivated plant or material, the climatic conditions and the specific compound of formula (I) used.
  • compositions e. g. solutions, emulsions, suspensions, dusts, powders, pastes, granules, pressings, capsules, and mixtures thereof.
  • composition types are suspensions (e. g. SC, OD, FS), emulsifiable concentrates (e. g. EC), emulsions (e. g. EW, EO, ES, ME), capsules (e. g. CS, ZC), pastes, pastilles, wettable powders or dusts (e. g.
  • compositions are prepared in a known manner, such as described by Mollet and Grubemann, Formulation technology, Wiley VCH, Weinheim, 2001; or Knowles, New developments in crop protection product Formulation, Agrow Reports DS243, T&F Informa, London, 2005.
  • Suitable auxiliaries are solvents, liquid carriers, solid carriers or fillers, surfactants, dispersants, emulsifiers, wetters, adjuvants, solubilizers, penetration enhancers, protective colloids, adhesion agents, thickeners, humectants, repellents, attractants, feeding stimulants, compatibilizers, bactericides, anti-freezing agents, anti-foaming agents, colorants, tackifiers and binders.
  • Suitable solvents and liquid carriers are water and organic solvents, such as mineral oil fractions of medium to high boiling point, e. g. kerosene, diesel oil; oils of vegetable or animal origin; aliphatic, cyclic and aromatic hydrocarbons, e. g. toluene, paraffin, tetrahydronaphthalene, alkylated naphthalenes; alcohols, e. g. ethanol, propanol, butanol, benzyl alcohol, cyclohexanol; glycols; DMSO; ketones, e. g. cyclohexanone; esters, e. g.
  • mineral oil fractions of medium to high boiling point e. g. kerosene, diesel oil
  • oils of vegetable or animal origin oils of vegetable or animal origin
  • aliphatic, cyclic and aromatic hydrocarbons e. g. toluene, paraffin, tetrahydronaphthalene, al
  • lactates carbonates, fatty acid esters, gamma-butyrolactone; fatty acids; phosphonates; amines; amides, e. g. N-methyl pyrrolidone, fatty acid dimethyl amides; and mixtures thereof.
  • Suitable solid carriers or fillers are mineral earths, e. g. silicates, silica gels, talc, kaolins, limestone, lime, chalk, clays, dolomite, diatomaceous earth, bentonite, calcium sulfate, magnesium sulfate, magnesium oxide; polysaccharides, e. g. cellulose, starch; fertilizers, e. g. ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas; products of vegetable origin, e. g. cereal meal, tree bark meal, wood meal, nutshell meal, and mixtures thereof.
  • Suitable surfactants are surface-active compounds, such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. Such surfactants can be used as emulsifier, dispersant, solubilizer, wetter, penetration enhancer, protective colloid, or adjuvant. Examples of surfactants are listed in McCutcheon's, Vol. 1: Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, USA, 2008 (International Ed. or North American Ed.).
  • Suitable anionic surfactants are alkali, alkaline earth or ammonium salts of sulfonates, sulfates, phosphates, carboxylates, and mixtures thereof.
  • sulfonates are alkylaryl sulfonates, diphenyl sulfonates, alpha-olefin sulfonates, lignin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated arylphenols, sulfonates of condensed naphthalenes, sulfonates of dodecyl- and tridecylbenzenes, sulfonates of naphthalenes and alkyl naphthalenes, sulfosuccinates or sulfosuccinamates.
  • Examples of sulfates are sulfates of fatty acids and oils, of ethoxylated alkylphenols, of alcohols, of ethoxylated alcohols, or of fatty acid esters.
  • Examples of phosphates are phosphate esters.
  • Examples of carboxylates are alkyl carboxylates, and carboxylated alcohol or alkylphenol ethoxylates.
  • Suitable nonionic surfactants are alkoxylates, N-substituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants, and mixtures thereof.
  • alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids or fatty acid esters which have been alkoxylated with 1 to 50 equivalents.
  • Ethylene oxide and/or propylene oxide may be employed for the alkoxylation, preferably ethylene oxide.
  • N-substituted fatty acid amides are fatty acid glucamides or fatty acid alkanolamides.
  • esters are fatty acid esters, glycerol esters or monoglycerides.
  • sugar-based surfactants are sorbitans, ethoxylated sorbitans, sucrose and glucose esters or alkylpolyglucosides.
  • polymeric surfactants are home- or copolymers of vinyl pyrrolidone, vinyl alcohols, or vinyl acetate.
  • Suitable cationic surfactants are quaternary surfactants, for example quaternary ammonium compounds with one or two hydrophobic groups, or salts of long-chain primary amines.
  • Suitable amphoteric surfactants are alkylbetains and imidazolines.
  • Suitable block polymers are block polymers of the A-B or A-B-A type comprising blocks of polyethylene oxide and polypropylene oxide, or of the A-B-C type comprising alkanol, polyethylene oxide and polypropylene oxide.
  • Suitable polyelectrolytes are polyacids or polybases. Examples of polyacids are alkali salts of polyacrylic acid or polyacid comb polymers. Examples of polybases are polyvinyl amines or polyethylene amines.
  • Suitable adjuvants are compounds, which have a negligible or even no pesticidal activity themselves, and which improve the biological performance of the compound of formula (I) on the target.
  • examples are surfactants, mineral or vegetable oils, and other auxiliaries. Further examples are listed by Knowles, Adjuvants and additives, Agrow Reports DS256, T&F Informa UK, 2006, chapter 5.
  • Suitable thickeners are polysaccharides (e. g. xanthan gum, carboxymethyl cellulose), inorganic clays (organically modified or unmodified), polycarboxylates, and silicates.
  • Suitable bactericides are bronopol and isothiazolinone derivatives such as alkylisothiazolinones and benzisothiazolinones.
  • Suitable anti-freezing agents are ethylene glycol, propylene glycol, urea and glycerin.
  • Suitable anti-foaming agents are silicones, long chain alcohols, and salts of fatty acids.
  • Suitable colorants are pigments of low water solubility and water-soluble dyes.
  • examples are inorganic colorants (e. g. iron oxide, titan oxide, iron hexacyanoferrate) and organic colorants (e. g. alizarin-, azo- and phthalocyanine colorants).
  • Suitable tackifiers or binders are polyvinyl pyrrolidones, polyvinyl acetates, polyvinyl alcohols, polyacrylates, biological or synthetic waxes, and cellulose ethers.
  • composition types and their preparation are:
  • a compound of formula (I) and 5-15 wt % wetting agent e. g. alcohol alkoxylates
  • a water-soluble solvent e. g. alcohols
  • a compound of formula (I) and 1-10 wt % dispersant e. g. polyvinyl pyrrolidone
  • organic solvent e. g. cyclohexanone
  • emulsifiers e. g. calcium dodecylbenzenesulfonate and castor oil ethoxylate
  • water-insoluble organic solvent e. g. aromatic hydrocarbon
  • Emulsions (EW, EO, ES)
  • emulsifiers e. g. calcium dodecylbenzenesulfonate and castor oil ethoxylate
  • 20-40 wt % water-insoluble organic solvent e. g. aromatic hydrocarbon
  • a compound of formula (I) 20-60 wt % of a compound of formula (I) are comminuted with addition of 2 10 wt % dispersants and wetting agents (e. g. sodium lignosulfonate and alcohol ethoxylate), 0.1-2 wt % thickener (e. g. xanthan gum) and water ad 100 wt % to give a fine active substance suspension. Dilution with water gives a stable suspension of the active substance.
  • dispersants and wetting agents e. g. sodium lignosulfonate and alcohol ethoxylate
  • 0.1-2 wt % thickener e. g. xanthan gum
  • water 100 wt % to give a fine active substance suspension.
  • Dilution with water gives a stable suspension of the active substance.
  • binder e. g. polyvinyl alcohol
  • 50-80 wt % of a compound of formula (I) are ground finely with addition of dispersants and wetting agents (e. g. sodium lignosulfonate and alcohol ethoxylate) ad 100 wt % and prepared as water-dispersible or water-soluble granules by means of technical appliances (e. g. extrusion, spray tower, fluidized bed). Dilution with water gives a stable dispersion or solution of the active substance.
  • dispersants and wetting agents e. g. sodium lignosulfonate and alcohol ethoxylate
  • lignosulfonate 1-3 wt % wetting agents (e. g. alcohol ethoxylate) and solid carrier (e. g. silica gel) ad 100 wt %.
  • wetting agents e. g. alcohol ethoxylate
  • solid carrier e. g. silica gel
  • a compound of formula (I) In an agitated ball mill, 5-25 wt % of a compound of formula (I) are comminuted with addition of 3-10 wt % dispersants (e. g. sodium lignosulfonate), 1-5 wt % thickener (e. g. carboxymethyl cellulose) and water ad 100 wt % to give a fine suspension of the active substance. Dilution with water gives a stable suspension of the active substance.
  • dispersants e. g. sodium lignosulfonate
  • 1-5 wt % thickener e. g. carboxymethyl cellulose
  • wt % of a compound of formula (I) are added to 5-30 wt % organic solvent blend (e. g. fatty acid dimethyl amide and cyclohexanone), 10-25 wt % surfactant blend (e. g. alcohol ethoxylate and arylphenol ethoxylate), and water ad 100%. This mixture is stirred for 1 h to produce spontaneously a thermodynamically stable microemulsion.
  • organic solvent blend e. g. fatty acid dimethyl amide and cyclohexanone
  • surfactant blend e. g. alcohol ethoxylate and arylphenol ethoxylate
  • An oil phase comprising 5-50 wt % of a compound of formula (I), 0-40 wt % water insoluble organic solvent
  • an oil phase comprising 5-50 wt % of a compound of formula (I) according to the invention, 0-40 wt % water insoluble organic solvent (e. g. aromatic hydrocarbon), and an isocyanate monomer (e. g.
  • diphenylmethene-4,4′-diisocyanatae are dispersed into an aqueous solution of a protective colloid (e. g. polyvinyl alcohol).
  • a protective colloid e. g. polyvinyl alcohol.
  • the addition of a polyamine results in the formation of polyurea microcapsules.
  • the monomers amount to 1-10 wt %.
  • the wt % relate to the total CS composition.
  • Dustable powders (DP, DS)
  • 1-10 wt % of a compound of formula (I) are ground finely and mixed intimately with solid carrier (e. g. finely divided kaolin) ad 100 wt %.
  • solid carrier e. g. finely divided kaolin
  • a compound of formula (I) 0.5-30 wt % are ground finely and associated with solid carrier (e. g. silicate) ad 100 wt %.
  • solid carrier e. g. silicate
  • Granulation is achieved by extrusion, spray-drying or fluidized bed.
  • organic solvent e. g. aromatic hydrocarbon
  • compositions types i) to xiii) may optionally comprise further auxiliaries, such as 0.1-1 wt % bactericides, 5-15 wt % anti-freezing agents, 0.1-1 wt % anti-foaming agents, and 0.1-1 wt % colorants.
  • auxiliaries such as 0.1-1 wt % bactericides, 5-15 wt % anti-freezing agents, 0.1-1 wt % anti-foaming agents, and 0.1-1 wt % colorants.
  • the agrochemical compositions generally comprise between 0.01 and 95%, preferably between 0.1 and 90%, and in particular between 0.5 and 75%, by weight of active ingredient (ai).
  • the active ingredients (ai) are employed in a purity of from 90% to 100%, preferably from 95% to 100% (according to NMR spectrum).
  • compositions in question give, after two-to-tenfold dilution, active substance concentrations of from 0.01 to 60% by weight, preferably from 0.1 to 40%, in the ready-to-use preparations.
  • Methods for applying the compound of formula (I), the combination and the composition thereof, respectively, onto plant propagation material, especially seeds include dressing, coating, pelleting, dusting, and soaking as well as in-furrow application methods.
  • the compound of formula (I), the combination and the composition thereof, respectively are applied on to the plant propagation material by a method such that germination is not induced, e. g. by seed dressing, pelleting, coating and dusting.
  • the amounts of active substances applied are, depending on the kind of effect desired, from 0.001 to 2 kg per ha, preferably from 0.005 to 2 kg per ha, more preferably from 0.05 to 1.0 kg per ha, and in particular from 0.1 to 1.0 kg per ha.
  • amounts of active substance from 0.1 to 1000 g, preferably from 1 to 1000 g, more preferably from 1 to 100 g and most preferably from 5 to 100 g, per 100 kg of plant propagation material (preferably seeds) are generally required.
  • the amount of active substance applied depends on the kind of application area and on the desired effect. Amounts customarily applied in the protection of materials are 0.001 g to 2 kg, preferably 0.005 g to 1 kg, of active substance per cubic meter of treated material.
  • oils, wetters, adjuvants, fertilizer, or micronutrients, and further pesticides may be added to the active substances or the compositions comprising them as premix or, if appropriate not until immediately prior to use (tank mix).
  • pesticides e. g. herbicides, insecticides, fungicides, growth regulators, safeners, biopesticides
  • These agents can be mixed with the composition according to the invention in a weight ratio of 1:100 to 100:1, preferably 1:20 to 20:1.
  • a pesticide is generally a chemical or biological agent (such as pesticidally active ingredient, compound, composition, virus, bacterium, antimicrobial or disinfectant) that through its effect deters, incapacitates, kills or otherwise discourages pests.
  • Target pests can include insects, plant pathogens, weeds, mollusks, birds, mammals, fish, nematodes (roundworms), and microbes that destroy property, cause nuisance, spread disease or are vectors for disease.
  • pesticide includes also plant growth regulators that alter the expected growth, flowering, or reproduction rate of plants; defoliants that cause leaves or other foliage to drop from a plant, usually to facilitate harvest; desiccants that promote drying of living tissues, such as unwanted plant tops; plant activators that activate plant physiology for defense of/against certain pests; safeners that reduce unwanted herbicidal action of pesticides on crop plants; and plant growth promoters that affect plant physiology e.g. to increase plant growth, biomass, yield or any other quality parameter of the harvestable goods of a crop plant.
  • the user applies the composition according to the invention usually from a predosage device, a knapsack sprayer, a spray tank, a spray plane, or an irrigation system.
  • the agrochemical composition is made up with water, buffer, and/or further auxiliaries to the desired application concentration and the ready-to-use spray liquor or the agrochemical composition according to the invention is thus obtained.
  • 20 to 2000 liters, preferably 50 to 400 liters, of the ready-to-use spray liquor are applied per hectare of agricultural useful area.
  • composition according to the invention such as parts of a kit or parts of a binary or ternary mixture may be mixed by the user himself in a spray tank or any other kind of vessel used for applications (e. g. seed treater drums, seed pelleting machinery, knapsack sprayer) and further auxiliaries may be added, if appropriate.
  • a spray tank or any other kind of vessel used for applications (e. g. seed treater drums, seed pelleting machinery, knapsack sprayer) and further auxiliaries may be added, if appropriate.
  • one embodiment of the invention is a kit for preparing a usable pesticidal composition, the kit comprising a) a composition comprising component 1) as defined herein and at least one auxiliary; and b) a composition comprising component 2) as defined herein and at least one auxiliary; and optionally c) a composition comprising at least one auxiliary and optionally a further active component 3) as defined herein.
  • the compound of formula (I), the combination and the composition thereof comprising them in the use as fungicides with other fungicides may result in an expansion of the fungicidal spectrum of activity being obtained or in a prevention of fungicide resistance development. Furthermore, in many cases, extraordinary effects are obtained.
  • the present invention provides a combination comprising at least one compound of formula (I) and at least one further pesticidally active substance selected from the group of fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, safeners, plant growth regulators, antibiotics, fertilizers and nutrients.
  • the pesticidally active substances reported in WO2015185485 pages 36-43 and WO2017093019 pages 42-56 can be used in conjunction with which the compound of formula (I).
  • component 2 The active substances referred to as component 2, their preparation and their activity e. g. against harmful fungi is known (cf.: http://www.alanwood.net/pesticides/); these substances are commercially available.
  • the compounds described by IUPAC nomenclature, their preparation and their pesticidal activity are also known (cf. Can. J. Plant Sci. 48(6), 587-94, 1968; EP141317; EP152031; EP226917; EP243970; EP256503; EP428941; EP532022; EP1028125; EP1035122; EP1201648; EP1122244, JP2002316902; DE19650197; DE10021412; DE102005009458; U.S. Pat. Nos.
  • the present invention furthermore relates to agrochemical mixtures comprising at least one compound of formula (I) (component 1) and at least one further active substance useful for plant protection.
  • the order of application is not essential for working of the present invention.
  • the time between both applications may vary e. g. between 2 hours to 7 days. Also a broader range is possible ranging from 0.25 hour to 30 days, preferably from 0.5 hour to 14 days, particularly from 1 hour to 7 days or from 1.5 hours to 5 days, even more preferred from 2 hours to 1 day.
  • the weight ratio of the component 1) and the component 2) generally depends from the properties of the active components used, usually it is in the range of 1:1000 to 1000:1, often in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1, even more preferably in the range of 1:4 to 4:1 and in particular in the range of 1:2 to 2:1.
  • the weight ratio of the component 1) and the component 2) usually is in the range of 1000:1 to 1:1000, often in the range of 100:1 to 1:100, regularly in the range of 50:1 to 1:50, preferably in the range of 20:1 to 1:20, more preferably in the range of 10:1 to 1:10, even more preferably in the range of 4:1 to 1:4 and in particular in the range of 2:1 to 1:2.
  • the weight ratio of component 1) and component 2) depends from the properties of the active substances used, usually it is in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1 and in particular in the range of 1:4 to 4:1, and the weight ratio of component 1) and component 3) usually it is in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1 and in particular in the range of 1:4 to 4:1.
  • any further active components are, if desired, added in a ratio of 20:1 to 1:20 to the component 1).
  • the present invention also relates to a process for preparing the compound of the present invention.
  • the process for preparing the compound of the present invention is described in the experimental section in more detail.
  • Step 2 —Ethyl 7-(N′-hydroxycarbamimidoyl)imidazo[1,2-a]pyridine-2-carboxylate
  • Step 3 —Ethyl 7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carboxylate
  • Step 4 —N-(3-methoxyphenyl)-7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carboxamide
  • Step 2 —Methyl-6-(N′-hydroxycarbamimidoyl)imidazo[1,2-a]pyridine-2-carboxylate
  • Step 3 —Ethyl 6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carboxylate
  • Step 4 —N-(3-methoxyphenyl)-6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carboxamide
  • yl)methanone 65 N-(2-methoxyethyl)-6-(5- 1 H-NMR (400 MHz, DMSO-d6) ⁇ 9.54 (s, 1H), 8.55 (s, (trifluoromethyl)-1,2,4-oxadiazol- 1H), 8.36 (d, 1H), 7.86 (dd, 1H), 7.80 (d, 1H), 3.45 (d, 3-yl)imidazo[1,2-a]pyridine-2- 4H), 3.26 (s, 3H); LCMS (M + H): 355.80.
  • carboxamide 66 N-isobutyl-6-(5-(trifluoromethyl)- 1 H-NMR (400 MHz, DMSO-d6) ⁇ 9.53 (d, 1H), 8.54 (s, 1,2,4-oxadiazol-3-yl)imidazo[1,2- 1H), 8.45 (t, 1H), 7.86 (dd, 1H), 7.79 (d, 1H), 3.10 (t, a]pyridine-2-carboxamide 2H), 1.90-1.83 (m, 1H), 0.87 (d, 6H); LCMS (M + H): 353.80.
  • yl)methanone 70 N-(cyclopropylmethyl)-6-(5- 1 H-NMR (400 MHz, DMSO-d6) ⁇ 9.54 (t, 1H), 8.54 (s, (trifluoromethyl)-1,2,4-oxadiazol- 1H), 8.51 (t, 1H), 7.86 (dd, 1H), 7.79 (d, 1H), 3.15 (t, 3-yl)imidazo[1,2-a]pyridine-2- 2H), 1.09-1.02 (m, 1H), 0.43-0.39 (m, 2H), 0.26-0.22 (m, carboxamide 2H); LCMS (M + H): 351.75.
  • carboxamide 76 N-(3-methoxybenzyl)-6-(5- 1 H-NMR (400 MHz, DMSO-d6) ⁇ 9.54 (d, 1H), 9.03 (s, (trifluoromethyl)-1,2,4-oxadiazol- 1H), 8.57 (d, 1H), 7.88-7.81 (m, 2H), 7.22 (t, 1H), 6.90 3-yl)imidazo[1,2-a]pyridine-2- (s, 2H), 6.81 (s, 1H), 4.44 (d, 2H), 3.72 (s, 3H); LCMS carboxamide (M + H): 418.20.
  • carboxamide 78 N-isobutyl-N-methyl-6-(5- 1 H-NMR (400 MHz, DMSO-d6) ⁇ 9.53 (t, 1H), 8.50 (d, (trifluoromethyl)-1,2,4-oxadiazol- 1H), 7.85 (d, 2H), 3.85 (d, 1H), 3.36 (d, 3H), 3.01 (s, 3-yl)imidazo[1,2-a]pyridine-2- 1H), 2.03 (dt, 1H), 0.92 (d, 3H), 0.80 (d, 3H); LCMS carboxamide (M + H): 368.30.
  • Step 3 —3-(2-(chloromethyl)imidazo[1,2-a]pyridin-7-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole
  • Step 4 —3-(2-((phenylthio)methyl)imidazo[1,2-a]pyridin-7-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole
  • reaction mixture was diluted with ethyl acetate (15 mL) and washed with water (15 mL).
  • the ethyl acetate layer was separated and dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain crude product.
  • the crude product was purified by flash column chromatography on silica gel using eluent 10% of ethyl acetate in hexane to obtain 3-(2-((phenylthio)methyl)imidazo[1,2-a]pyridin-7-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole (1.03 g, 2.73 mmol, 83% yield).
  • 1,2,4-oxadiazole 52 5-(trifluoromethyl)-3-(2-(((4- 1 H-NMR (400 MHz, CHLOROFORM-D) ⁇ 8.40 (s, (trifluoromethyl)phenyl)thio)meth- 1H), 8.16 (dd, 1.0 Hz, 1H), 7.65 (d, 1H), 7.51-7.42 yl)imidazo[1,2-a]pyridin-7-yl)-1,2,4- (m, 5H), 4.41 (s, 2H); LCMS (M + H): 445.00.
  • oxadiazole 53 3-(2-(((4- 1 H-NMR (400 MHz, CHLOROFORM-D) ⁇ 8.39 (s, methoxybenzyl)thio)methyl)imidazo[1,2- 1H), 8.22-8.16 (m, 1H), 7.59 (s, 1H), 7.48 (dd, 1.7 a]pyridin-7-yl)-5- Hz, 1H), 7.31-7.20 (m, 2H), 6.92-6.81 (m, 2H), 4.00- (trifluoromethyl)-1,2,4-oxadiazole 3.53 (m, 7H); LCMS (M + H): 421.05.
  • the organic layer was separated and dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain crude product.
  • the crude product was purified by flash column chromatography on silica gel using eluent 30% of ethyl acetate in hexane to obtain 3-(2-((phenylsulfonyl)methyl)imidazo[1,2-a]pyridin-7-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole (0.156 g, 0.382 mmol, 58% yield).
  • Step 1 —3-(2-(azidomethyl)imidazo[1,2-a]pyridin-6-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole
  • Step 2 —(6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2yl)methanamine
  • Step 3 —N-((6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2-yl)methyl)benzamide
  • Step 2 —(Z)-2-(chloromethyl)-N′-hydroxyimidazo[1,2-a]pyridine-6-carboximidamide
  • Step 3 —3-(2-(chloromethyl)imidazo[1,2-a]pyridin-6-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole
  • the product was extracted into ethyl acetate (150 mL). The ethyl acetate layer was washed with water (50 mL), dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain a crude product.
  • the crude product was purified by column chromatography on silica gel using eluent 0-50% ethyl acetate in hexane to obtain 3-(2-(chloromethyl)imidazo[1,2-a]pyridin-6-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole (3 g, 9.91 mmol, 97% yield) and 2-(ethoxymethyl)-N′-hydroxyimidazo[1,2-a]pyridine-6-carboximidamide.
  • Step 4 —3-(2-(((4-methoxyphenyl)thio)methyl)imidazo[1,2-a]pyridin-6-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole
  • the ethyl acetate layer was dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain crude product.
  • the crude product was purified by flash column chromatography on silica gel using eluent 20% ethyl acetate in hexane to obtain 3-(2-(((4-methoxyphenyl)thio)methyl)imidazo[1,2-a]pyridin-6-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole (244 mg, 0.6 mmol, 37% yield).
  • Example 8 Preparation of N-(methyl(oxo)(phenyl)- ⁇ 6 -sulfanylidene)-2-(6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide (Compound No. 129)
  • Step 2 —ethyl 2-(6-(N′-hydroxycarbamimidoyl)imidazo[1,2-a]pyridin-2-yl)acetate
  • Step 3 —ethyl 2-(6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2-yl)acetate
  • Step 4 —N-(methyl(oxo)(phenyl)- ⁇ 6 -sulfanylidene)-2-(6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide
  • the reaction mixture was cooled to 25° C. and poured into ice cold solution of 10% aqueous acetic acid solution (10 mL).
  • the product was extracted with ethyl acetate (30 mL).
  • the ethyl acetate layer was washed with aqueous sodium bicarbonate solution (10 mL), dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain the crude product.
  • Step 4 —3-(2-((methylthio)methyl)imidazo[1,2-a]pyridin-7-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole
  • Step 5 —Imino(methyl)((7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2-yl)methyl)- ⁇ 6 -sulfanone
  • the obtained crude residue was diluted with ethyl acetate (50 mL) and the solution was neutralized with sodium bicarbonate (80 mL) solution.
  • the ethyl acetate layer was collected and aqueous layer was extracted thrice with ethyl acetate (50 mL).
  • the combined ethyl acetate layers were dried over anhydrous sodium sulphate and concentrated under reduced pressure.
  • Step 6 —N-(Methyl(oxo)((7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2-yl)methyl)- ⁇ 6 -sulfaneylidene)benzamide
  • the resulting reaction mixture was diluted with water, extracted twice with ethyl acetate (20 mL), washed twice with brine (20 mL), dried over sodium sulphate and concentrated under reduced pressure.
  • the obtained crude product was purified by flash column chromatography on silica gel using eluent 80% of ethyl acetate in hexane to obtain N-(methyl(oxo)((7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2-yl)methyl)- ⁇ 6 -sulfanylidene)benzamide (0.124 g, 0.276 mmol, 48% yield).
  • Step 3 —3-(2-(chloromethyl)imidazo[1,2-a]pyridin-7-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole
  • Step 4 —3-(2-((phenylthio)methyl)imidazo[1,2-a]pyridin-7-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole
  • Step 5 —Imino(phenyl)((7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2-yl)methyl)- ⁇ 6 -sulfanone
  • Step-1 —6-(5-(trifluoromethyl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carbaldehyde
  • Step-2 —6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridine-2-carbaldehyde
  • Step 3 (3-fluorophenyl)(methyl)(((6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-2-yl)methyl)imino)- ⁇ 6 -sulfanone
  • Example 12 Preparation of (3-fluorophenyl)(methyl)((2-methyl-6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-3-yl)imino)- ⁇ 6 -sulfanone (Compound No. 170)
  • Step-1 —3-(((3-fluorophenyl)(methyl)(oxo)- ⁇ 6 -sulfaneylidene)amino)-2-methylimidazo[1,2-a]pyridine-6-carbonitrile
  • Step-2 —3-(((3-fluorophenyl)(methyl)(oxo)- ⁇ 6 -sulfaneylidene)amino)-N′-hydroxy-2-methylimidazo[1,2-a]pyridine-6-carboximidamide
  • Step-3 (3-fluorophenyl)(methyl)((2-methyl-6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-3-yl)imino)- ⁇ 6 -sulfanone
  • Step b —3-bromo-2-(trifluoromethyl)imidazo[1,2-a]pyridine-7-carbonitrile
  • Step c 3-(((2-fluorophenyl)(methyl) (oxo)- ⁇ 6 -sulfanylidene)amino)-2-(trifluoromethyl)imidazo[1,2-a]pyridine-7-carbonitrile
  • the resulting reaction mixture was purged with nitrogen for 2 min and stirred at 110° C. for 16 h.
  • the reaction mixture was cooled to 25° C. and filtered through a pad of celite.
  • the filter cake was washed with ethyl acetate (20 mL).
  • the filtrate was washed with water (5 mL) and brine solution (5 mL).
  • the ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure.
  • Step d —3-(((2-fluorophenyl)(methyl)(oxo)- ⁇ 6 -sulfanylidene)amino)-N′-hydroxy-2-(trifluoromethyl)imidazo[1,2-a]pyridine-7-carboximidamide
  • Step e —(2-fluorophenyl)(methyl)((2-(trifluoromethyl)-7-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-3-yl)imino)- ⁇ 6 -sulfanone
  • reaction mixture was quenched by sodium bicarbonate solution (2 mL), extracted in dichloromethane (20 mL) and washed with water (5 mL) and brine solution (5 mL). The dichloromethane layer was dried over anhydrous sodium sulphate and concentrated under reduced pressure.
  • the compounds of general formula (I) show fungicidal activities which are exerted with respect to numerous phytopathogenic fungi which attack on important agricultural crops.
  • the compounds of the present invention were assessed for their activity as described in the following tests:
  • a visual assessment of the compound's performance was carried out by rating the disease severity (0-100% scale) on treated plants 3, 7, 10 and 15 days after application. Efficacy (% control) of the compounds was calculated by comparing the disease rating in the treatment with the one of the untreated control. The sprayed plants were also assessed for plant compatibility by recording symptoms like necrosis, chlorosis and stunting.

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  • Engineering & Computer Science (AREA)
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  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cultivation Of Plants (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
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TW202104222A (zh) 2021-02-01
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AR118612A1 (es) 2021-10-20
AU2020270549A1 (en) 2021-09-30
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