US20130039866A1 - Composition for the prophylaxis of candidiasis - Google Patents
Composition for the prophylaxis of candidiasis Download PDFInfo
- Publication number
- US20130039866A1 US20130039866A1 US13/635,909 US201113635909A US2013039866A1 US 20130039866 A1 US20130039866 A1 US 20130039866A1 US 201113635909 A US201113635909 A US 201113635909A US 2013039866 A1 US2013039866 A1 US 2013039866A1
- Authority
- US
- United States
- Prior art keywords
- composition according
- composition
- sodium
- group containing
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
Definitions
- the invention relates to dentistry and perfume industries, and specifically to compositions for the prevention of candidiases of the skin and mucosal surfaces (in the mouth, vagina, and the like) in humans.
- the composition may be a gel for oral hygiene or for application to the human skin or mucosal surfaces, toothpaste, a cream for application to the skin, or a liquid formulation useful for mouth rinsing or washing the human mucosal surfaces or skin or for application to the skin.
- the antifungal medications currently used for the prevention and treatment of diseases caused by Candida yeast fungi have a broad spectrum of side effects and thereby have limited applicability.
- Clotrimazole-containing medications (creams and ointments for topical application, solutions for topical application) are the most common topical medications. Contraindications are as follows: hypersensitivity, pregnancy, and with caution during lactation.
- nystatin ointment is prescribed for preventing the development of candidiasis during long-term treatment with penicillin drugs and other antibiotics, as well as for weakened and depleted patients.
- the side effects are allergic reactions.
- Miconazole is administered topically to patients with fungal infections of the skin and nails. In skin diseases, a small amount of liquid is applied to the affected areas and rubbed in, until it is completely absorbed. Application to the skin causes local irritation, allergic reactions, and skin rash.
- oral administration in the form of a gel is prescribed to adults and children. It is recommended not to swallow the gel immediately, but to take it in the mouth as long as possible. Oral miconazole is contraindicated in pregnancy and congenital hepatic dysfunction (see M. D. Mashkovsky, “Medications,” Moscow: Novaya Volna Publishing House, S. B. Divov Publisher, 2002, Vol. 2, pp. 353-365).
- a pharmaceutical composition is known in the form of mouthwashes, comprising chlorhexidine and glutaraldehyde. This composition is recommended for the prevention and treatment of fungal diseases of the oral cavity caused by Candida albicans and in patients suffering from AIDS, cancer, or periodontal diseases (see U.S. Pat. No. 5,549,885 A, IPC A61K 7/16, 1996).
- An anticandidal prophylactic agent is known for fixing dentures, which comprises xylitol to reduce the formation of plaque on dentures (see JP2000333973 A, IPC A61C 13/23, 2000).
- This prior-art prophylactic agent has an insignificant level of antifungal effect. Furthermore, its application is limited only to the oral cavity and only to removable dentures.
- the problem to be solved by the invention consists of the embodiment of an efficient prophylactic composition that uses available and safe components and that can be recommended for preventing candidiasis of the skin and/or mucous membranes in people who belong to the group of risk, namely: sufferers of diabetes mellitus; people with blood diseases, immune deficiency, or other serious pathologies; patents subjected to hormone therapy, antibiotic therapy, or chemotherapy; babies and pregnant women; and people using dentures.
- composition for the prophylaxis of candidiasis comprising:
- active agents in weight percent, namely:
- the composition can be manufactured as a gel, toothpaste, a cosmetic emulsion cream, or as a liquid formulation.
- the prophylactic composition comprises the following inert components, in percent by weight
- the prophylactic composition comprises the following inert components, in percent by weight
- the prophylactic composition comprises the following inert components, in percent by weight:
- the prophylactic composition comprises the following inert components, in percent by weight:
- the prophylactic composition comprises, in percent by weight:
- the moistening component useful in preparing the prophylactic composition can be one or more of substances selected from the group containing: sorbitol, glycerol, polyethylene glycol, and propylene glycol.
- the useful abrasive component can be one or more of substances selected from the group containing: silica, polymethacrylate, calcium pyrophosphate, and sodium bicarbonate.
- the gelling component useful for preparing the prophylactic composition in the form of a gel or toothpaste can be one or more of substances selected from the group containing: hydroxyethylcellulose, xanthan gum, guar gum, and carboxymethylcellulose.
- the surfactant useful in preparing the prophylactic composition in any of the above-listed dosage forms can be one or more of substances selected from the group containing: sodium lauryl sulfate, sodium lauryl sarcosinate, glyceryl stearate citrate, glyceryl oleate citrate, potassium cetyl phosphate, cetearyl alcohol, glyceryl monostearate, hydrogenated castor oil, polysorbate 20, cetearyl glycoside, sorbitan isostearate, and alkylamidobetain.
- the emollient useful for preparing the prophylactic composition in the form of a cosmetic emulsion cream can be one or more of substances selected from the group containing: caprylic triglycerides, isopropyl myristate, cetearylethyl hexanoate, olive oil, avocado oil, jojoba oil, Shea Butter, wheat germ oil, sunflower seed oil, dimethicone, and cyclomethicone.
- the structuring agent useful for preparing the prophylactic composition in the form of a cosmetic emulsion cream can be one or more of substances selected from the group containing: C14-16 fatty alcohols, stearic acid, and palmitic acid.
- the anticaries component useful for preparing the prophylactic composition in the form of toothpaste can be one or more of substances selected from the group containing: sodium fluoride, potassium fluoride, sodium monofluorophosphate, potassium monofluorophosphate, and magnesium glycerophosphate.
- the fragrance useful for preparing the prophylactic composition in the form of a gel, toothpaste, a liquid formulation, or a cosmetic emulsion cream can be one or more of substances selected from the group containing:
- essential oils derived from peppermint, spearmint, sage, eucalyptus, thyme, clove, wintergreen, anise, orange, mandarin, grapefruit, lemon, bergamot, neroli, lavender, and rose;
- menthol carvone, anethole, eucalyptol, methyl salicylate, phenoxyethanol, citronellol, geraniol, nerol, limonene, and citral.
- the sweetener useful for preparing the prophylactic composition in the form of toothpaste or a liquid formulation can be one or more of substances selected from the group containing: sodium saccharinate, potassium aspartame, stevioside, and potassium or sodium glycyrrhizate.
- the preservative useful in preparing the prophylactic composition in any of the aforementioned dosage forms can be one or more of substances selected from the group containing: methylparaben, propylparaben or sodium salts thereof, sodium benzoate, and potassium sorbate.
- Candida albicans is the most frequent causative agent of candidiasis (in up to 62% of the incidences).
- the factors favoring the occurrence of candidiasis are as follows: neonatal or elderly age, nutritional deficiency, antibiotics, tumors, HIV infection, chemotherapy, hormone therapy, and wearing of dentures.
- the manifestation of the disease depends on the condition of the colonized tissue, the virulence factors of Candida , and the severity of the host immune response.
- Candidiasis is known to develop in the presence of certain physiological changes in the human body and various pathological states, and as a consequence of adverse effects (such as the use of cytotoxic drugs, antibiotics, or hormones). While mild candidiasis incidences occurring mainly among children have previously been reported, currently severe visceral and generalized forms are much more frequent.
- the initial phase of colonization is adhesion, which is implemented through a variety of mechanisms for the recognition of host tissues by a pathogen (fungus).
- Candida albicans is able of binding to various substrates, such as mucosal (buccal, vaginal, dermal, and other) epitheliocytes, endotheliocytes, and inert surfaces (various polymers used in medical procedures).
- Adhesion in a macroorganism-microorganisms system depends on the external environment which, on the one hand, acts through the Candida and, on the other, affects indirectly through the host.
- Candida -dependent mechanisms include the surface hydrophobicity of the fungus, the type of culture medium, and growth conditions.
- the adhesive potential of the cells of a macroorganism is affected by the hormonal and immune status of the host. Attachment of Candida to host cells initiates colonization and the infection process. This concept is just the underlying idea of attempts at preventing the development of infections by blocking the adhesion of Candida to host tissues (see E. G. Zelenova, M. I. Zaslayskaya, E. V. Salina, and S. P. Rassanov, “Oral Microflora: Normality and Pathology. Textbook,” Nizhni Novgorod: NGMA Publishing House, 2004, p. 121).
- Xylitol is known to have a certain anti-adhesive potential against Candida fungi.
- the use in children aged 12 to 36 months of a gel comprising 10% xylitol for a period of 1 month was shown to have a positive effect on the microbiota composition of the tooth biofilm by normalizing the qualitative composition (speciation), and to result in the disappearance of Candida fungi (see E. V. Kirillova, V. N. Tsarev, L. P. Kiselnikova, and V. O.
- the invention uses water-soluble alginic acid salts for enhancing the efficacy of the xylitol-comprising preparations for the reason that they provide a prolonged antibacterial effect and are sorbents for circulating immune complexes (see L. K. Dobrodeeva and K. G. Dobrodeev, “Immunomodulators of Plant and Algal Origin: A Monograph,” Arkhangelsk: Arkhangelsk State Technical University, 2008, pp. 238-239).
- the gel formulation is prepared in the following manner.
- the required amount of water is weighed in a measuring vessel; the water is poured to a mixer to which methylparaben, sorbitol, and xylitol are then added. The mixture is stirred for 20 min to obtain a clear solution.
- a suspension of alginates and hydroxyethylcellulose in glycerol is prepared separately. This suspension is added to the above aqueous solution and stirred for 20 to 30 min to obtain a homogeneous gel.
- polysorbate 20 is heated to a temperature of 40 to 45° C., a fragrance is added, and stirred for 10 min to obtain a homogeneous mixture.
- the resultant mixture is added to the gel, sodium lauryl sulfate is added, and stirred for 20-30 min to obtain a homogeneous mixture.
- the gel prepared in this way is packed into tubes made of a polymeric material.
- the toothpaste is prepared in the following manner.
- glycerol is weighed, and xanthan gum and alginates are added thereto. The mixture is stirred to obtain a homogeneous mass.
- the required amount of water is weighed in a dispenser, and the water is poured to a mixer to which sodium saccharinate, parabens, sorbitol, xylitol, sodium fluoride, sodium monofluorophosphate, and magnesium glycerophosphate are then added. The mixture is stirred to obtain a clear solution.
- the resulting solution is added with a suspension of xanthan gum and alginates in glycerol and stirred to obtain a homogeneous mass.
- the formulation is degassed and stirred for 10 min to completely remove air from the mixture.
- silica and then sodium bicarbonate are added, evacuated, and stirred for 30 to 40 min.
- the toothpaste is homogenized for 10 to 20 min by means of a homogenizer pump.
- a fragrance and sodium lauryl sulfate (or alkylamidobetain) are added to the mixer and stirred for 20 to 30 min to obtain a homogeneous mass.
- the toothpaste prepared in this way is packed into tubes made of a polymeric material.
- the required amount of water is heated in a dispenser to 40-45° C. and poured to a mixer to which stevioside and xylitol are then added. The mixture is stirred for 10 to 15 min to obtain a clear solution.
- Methylparaben is dissolved in propylene glycol in a separate vessel under stirring; then this solution is added to the main mixer and stirred to obtain a clear solution.
- Glycerol is charged into a separate vessel, and alginate is added under stirring. Then, the suspension obtained in this way is added to the main solution.
- Polysorbate 20 is separately heated to a temperature of 40 to 45° C., a fragrance is added, stirred for 10 min to obtain a homogeneous mixture, and then added to the mixture obtained at the preceding step.
- composition is stirred for 20 min to obtain a clear or slightly opalescent solution.
- Sodium lauryl sulfate is added; the solution is stirred for 20 min and dispensed into plastic bottles.
- Olive oil, jojoba oil, dimethicone, stearic acid, caprylic triglycerides, glyceryl monostearate, glyceryl oleate citrate, and C14-16 fatty alcohols are placed into a separate vessel, and melted at 55-60° C.
- the oil phase is poured to the aqueous phase under stirring, and emulsified for 15-20 min under stirring and heating at 55-60° C.
- the emulsion is cooled to a temperature of 40 to 50° C., and a fragrance is added under stirring.
- the cream is homogenized for 1-2 min at a temperature of 40 to 50° C. at a homogenizer speed of 5000 to 7000 rpm.
- the ready for use cream is packed into polymer tubes or jars.
- the efficacy was verified by a laboratory method as the degree of destruction of the monolayer of skin-muscle human embryo fibroblasts, that is, as the degree of reduction of the toxic effect.
- test microorganism culture was a laboratory Candida albicans strain; the microbial load was 106-7 CFU/g. The exposure time was 4 hours.
- the toothpaste prepared according to the invention and the placebo toothpaste had the formulations as shown in Table 5.
- compositions for preventing candidiases have been prepared on the basis of xylitol and water-soluble sodium and/or potassium salts of alginic acid, which are safe for humans, specifically, for babies.
- This composition can be used by people who belong to the group of risk, namely: sufferers of diabetes mellitus, people with blood diseases, immune deficiency, or other severe pathologies; patents subjected to hormone therapy, antibiotic therapy, or chemotherapy; babies and pregnant women; and people using dentures.
- the active components of the composition are available throughout the world and allowed for use as dietary supplements.
- the composition for preventing candidiases may be prepared in the form of a gel for oral hygiene or for application to the human skin or mucosal surfaces, in the form of toothpaste, in the form of a cream for application to the skin, or a liquid formulation for mouth rinsing or washing the human mucosal surfaces or skin and/or for application to the skin.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201001053 | 2010-07-08 | ||
EA201001053A EA201001053A1 (ru) | 2010-07-08 | 2010-07-08 | Состав для профилактики кандидозов |
PCT/RU2011/000407 WO2012005622A1 (ru) | 2010-07-08 | 2011-06-09 | Состав для профилактики кандидозов |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/RU2011/000407 A-371-Of-International WO2012005622A1 (ru) | 2010-07-08 | 2011-06-09 | Состав для профилактики кандидозов |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/729,463 Division US9597276B2 (en) | 2010-07-08 | 2015-06-03 | Composition for the prophylaxis of candidiasis |
Publications (1)
Publication Number | Publication Date |
---|---|
US20130039866A1 true US20130039866A1 (en) | 2013-02-14 |
Family
ID=44925755
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/635,909 Abandoned US20130039866A1 (en) | 2010-07-08 | 2011-06-09 | Composition for the prophylaxis of candidiasis |
US14/729,463 Active US9597276B2 (en) | 2010-07-08 | 2015-06-03 | Composition for the prophylaxis of candidiasis |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/729,463 Active US9597276B2 (en) | 2010-07-08 | 2015-06-03 | Composition for the prophylaxis of candidiasis |
Country Status (17)
Country | Link |
---|---|
US (2) | US20130039866A1 (ru) |
EP (1) | EP2545899B1 (ru) |
JP (1) | JP5932786B2 (ru) |
CN (2) | CN104274339A (ru) |
CY (1) | CY1122427T1 (ru) |
DK (1) | DK2545899T3 (ru) |
EA (1) | EA201001053A1 (ru) |
ES (1) | ES2766377T3 (ru) |
HR (1) | HRP20192300T1 (ru) |
HU (1) | HUE048512T2 (ru) |
LT (1) | LT2545899T (ru) |
PL (1) | PL2545899T3 (ru) |
PT (1) | PT2545899T (ru) |
RS (1) | RS59656B1 (ru) |
SI (1) | SI2545899T1 (ru) |
UA (1) | UA107487C2 (ru) |
WO (1) | WO2012005622A1 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150297490A1 (en) * | 2012-11-26 | 2015-10-22 | Apollonia Health Inc. | Compositions, uses and methods for treating or preventing dental caries |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2014105805A (ru) * | 2013-06-07 | 2015-08-27 | Валерий Валентинович Правдин | Многофункциональная зубная паста |
JP6513667B2 (ja) | 2013-08-08 | 2019-05-15 | ノヴァン,インコーポレイテッド | 局所用組成物およびそれを使用する方法 |
US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
CN104434686A (zh) * | 2014-12-10 | 2015-03-25 | 唯美度科技(北京)有限公司 | 一种含红加仑提取物眼霜及其制备方法 |
WO2018203327A1 (en) * | 2017-04-30 | 2018-11-08 | Resdevco Research And Development Co. Ltd. | Composition containing phenethyl alcohol for treatment of candida infection |
EP3698769B1 (en) * | 2019-02-22 | 2023-06-07 | Steven De Mars | An oral remineralization accelerating composition |
WO2020190872A1 (en) * | 2019-03-18 | 2020-09-24 | Sunstar Americas, Inc. | Oral care composition |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986002831A1 (en) * | 1984-11-08 | 1986-05-22 | Zetachron, Inc. | Dentifrice containing alginate calcium chelating agent |
US4795630A (en) * | 1985-04-10 | 1989-01-03 | Lion Corporation | Method for manufacturing toothpaste |
WO1993025183A1 (en) * | 1992-06-16 | 1993-12-23 | Smithkline Beecham Plc | Mouthwash for treating dentine hypersensitivity |
US5695746A (en) * | 1995-07-28 | 1997-12-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Liquid dentifrice with mouthwash fresh taste |
US5707610A (en) * | 1992-10-28 | 1998-01-13 | Den-Mat Corporation | Antibacterial mouthwash |
JP2003081795A (ja) * | 2001-09-17 | 2003-03-19 | Lion Corp | 歯磨組成物 |
US20040057908A1 (en) * | 2001-12-13 | 2004-03-25 | Bowen William H. | Oral compositions and use thereof |
US20040224287A1 (en) * | 2000-12-21 | 2004-11-11 | Sang-Ki Park | Oral compositions against halitosis |
US20050025720A1 (en) * | 2003-06-20 | 2005-02-03 | Donald W. Bailey | Xylitol dental maintenance system |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775525A (en) * | 1985-12-16 | 1988-10-04 | Ivo Pera | Oral hygiene formulation containing sodium alginate |
GB9402877D0 (en) | 1994-02-15 | 1994-04-06 | Torchinsky Alick | Mouthwash |
US6121315A (en) * | 1996-09-20 | 2000-09-19 | Warner-Lambert Company | Oral compositions containing a zinc compound |
CN1197584C (zh) * | 1997-04-30 | 2005-04-20 | 雷克特本克斯尔保健(英国)有限公司 | 可倾倒的藻酸盐组合物 |
ES2132033B1 (es) * | 1997-11-06 | 2000-03-01 | Dentaid Sa | Composicion oral para el tratamiento de la halitosis. |
FI974385A0 (fi) * | 1997-12-01 | 1997-12-01 | Xyrofin Oy | Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning |
JP2000333973A (ja) * | 1999-05-28 | 2000-12-05 | Lion Corp | キシリトールを含有する義歯安定剤 |
DE19941933A1 (de) * | 1999-09-03 | 2001-03-15 | Cognis Deutschland Gmbh | Tensidsysteme |
US6531141B1 (en) * | 2000-03-07 | 2003-03-11 | Ortho-Mcneil Pharmaceutical, Inc. | Oil-in-water emulsion containing tretinoin |
NL1018421C1 (nl) * | 2001-06-29 | 2003-01-07 | Sara Lee De Nv | Mondverzorgingsmiddel. |
EP1297821A1 (en) * | 2001-10-01 | 2003-04-02 | Hive of Beauty (Europe) BVBA | Skin treatment compositions |
CN1433752A (zh) * | 2002-01-21 | 2003-08-06 | 权力敏 | 海洋生物素净足液 |
JP2004269437A (ja) * | 2003-03-10 | 2004-09-30 | Nissen Techno:Kk | 歯磨き剤 |
CA2526626C (en) * | 2003-05-29 | 2012-08-28 | Sun Pharmaceuticals Corporation | Emulsion base for skin care compositions |
WO2005016307A1 (en) * | 2003-07-30 | 2005-02-24 | Stiefel Laboratories, Inc. | Steroidal compositions containing hydroxycarboxylic acids and methods of using the same |
JP2005187333A (ja) * | 2003-12-24 | 2005-07-14 | Lion Corp | う蝕予防用塗布剤組成物 |
JP2008505113A (ja) * | 2004-07-02 | 2008-02-21 | ディスカス デンタル インプレッションズ インコーポレーテッド | 感受性軽減効果を有する歯科用組成物 |
US8858920B2 (en) * | 2004-12-21 | 2014-10-14 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
JP2008303188A (ja) * | 2007-06-08 | 2008-12-18 | Univ Of Tokushima | カンジダバイオフィルム除去剤 |
JP4919060B2 (ja) * | 2007-06-28 | 2012-04-18 | ライオン株式会社 | 口腔用組成物及びアルジンジパイン阻害剤 |
US8828363B2 (en) * | 2007-08-03 | 2014-09-09 | Gary H. EIREW | Pharmaceutical composition for improving oral hygiene and methods thereof |
-
2010
- 2010-07-08 EA EA201001053A patent/EA201001053A1/ru unknown
-
2011
- 2011-06-09 HU HUE11803866A patent/HUE048512T2/hu unknown
- 2011-06-09 PT PT118038660T patent/PT2545899T/pt unknown
- 2011-06-09 EP EP11803866.0A patent/EP2545899B1/en active Active
- 2011-06-09 CN CN201410568964.6A patent/CN104274339A/zh active Pending
- 2011-06-09 UA UAA201212076A patent/UA107487C2/ru unknown
- 2011-06-09 WO PCT/RU2011/000407 patent/WO2012005622A1/ru active Application Filing
- 2011-06-09 JP JP2013518309A patent/JP5932786B2/ja active Active
- 2011-06-09 ES ES11803866T patent/ES2766377T3/es active Active
- 2011-06-09 US US13/635,909 patent/US20130039866A1/en not_active Abandoned
- 2011-06-09 RS RS20191607A patent/RS59656B1/sr unknown
- 2011-06-09 CN CN2011800204075A patent/CN102858311A/zh active Pending
- 2011-06-09 PL PL11803866T patent/PL2545899T3/pl unknown
- 2011-06-09 SI SI201131823T patent/SI2545899T1/sl unknown
- 2011-06-09 DK DK11803866.0T patent/DK2545899T3/da active
- 2011-06-09 LT LTEP11803866.0T patent/LT2545899T/lt unknown
-
2015
- 2015-06-03 US US14/729,463 patent/US9597276B2/en active Active
-
2019
- 2019-12-18 CY CY20191101331T patent/CY1122427T1/el unknown
- 2019-12-20 HR HRP20192300TT patent/HRP20192300T1/hr unknown
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986002831A1 (en) * | 1984-11-08 | 1986-05-22 | Zetachron, Inc. | Dentifrice containing alginate calcium chelating agent |
US4795630A (en) * | 1985-04-10 | 1989-01-03 | Lion Corporation | Method for manufacturing toothpaste |
WO1993025183A1 (en) * | 1992-06-16 | 1993-12-23 | Smithkline Beecham Plc | Mouthwash for treating dentine hypersensitivity |
US5707610A (en) * | 1992-10-28 | 1998-01-13 | Den-Mat Corporation | Antibacterial mouthwash |
US5695746A (en) * | 1995-07-28 | 1997-12-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Liquid dentifrice with mouthwash fresh taste |
US20040224287A1 (en) * | 2000-12-21 | 2004-11-11 | Sang-Ki Park | Oral compositions against halitosis |
JP2003081795A (ja) * | 2001-09-17 | 2003-03-19 | Lion Corp | 歯磨組成物 |
US20040057908A1 (en) * | 2001-12-13 | 2004-03-25 | Bowen William H. | Oral compositions and use thereof |
US20050025720A1 (en) * | 2003-06-20 | 2005-02-03 | Donald W. Bailey | Xylitol dental maintenance system |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150297490A1 (en) * | 2012-11-26 | 2015-10-22 | Apollonia Health Inc. | Compositions, uses and methods for treating or preventing dental caries |
Also Published As
Publication number | Publication date |
---|---|
JP5932786B2 (ja) | 2016-06-08 |
CY1122427T1 (el) | 2021-01-27 |
HUE048512T2 (hu) | 2020-08-28 |
PL2545899T3 (pl) | 2020-05-18 |
RS59656B1 (sr) | 2020-01-31 |
US20150265517A1 (en) | 2015-09-24 |
EP2545899A1 (en) | 2013-01-16 |
HRP20192300T1 (hr) | 2020-03-06 |
PT2545899T (pt) | 2019-12-18 |
CN104274339A (zh) | 2015-01-14 |
ES2766377T3 (es) | 2020-06-12 |
EP2545899A4 (en) | 2015-11-04 |
LT2545899T (lt) | 2020-01-27 |
UA107487C2 (ru) | 2015-01-12 |
US9597276B2 (en) | 2017-03-21 |
EP2545899B1 (en) | 2019-11-27 |
WO2012005622A1 (ru) | 2012-01-12 |
EA015747B1 (ru) | 2011-10-31 |
DK2545899T3 (da) | 2020-01-27 |
CN102858311A (zh) | 2013-01-02 |
JP2013530221A (ja) | 2013-07-25 |
EA201001053A1 (ru) | 2011-10-31 |
SI2545899T1 (sl) | 2020-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9597276B2 (en) | Composition for the prophylaxis of candidiasis | |
DE69033994T2 (de) | Flüssige Polymerzusammensetzung und Verfahren zu ihrer Verwendung | |
RU2683779C2 (ru) | Композиции и способы повышения эффективности местного нанесения кислотного полезного агента | |
US5648399A (en) | Liquid polymer composition and method of use | |
HUE030028T2 (en) | Antifungal drug | |
EP2736504A1 (en) | Sandalwood oil and its uses related to skin disorders | |
RU2699560C1 (ru) | Стоматологический гель с фитопелоидной композицией | |
US8507452B2 (en) | Hesperidin-containing composition | |
CN108042420B (zh) | 一种用于口腔保健的组合物及其应用 | |
EA012247B1 (ru) | Лечебно-профилактический состав для ухода за полостью рта | |
JP2012144480A (ja) | 口腔用組成物 | |
CN104606085B (zh) | 一种抗菌的醋酸洗必泰纳米乳漱口液及其制备方法 | |
US20060088481A1 (en) | Topical oral dosage forms containing bismuth compounds | |
EP2906179B1 (en) | Topical ubiquinol oral supplement compositions with amorphous calcium phosphate | |
KR19990003843A (ko) | 잇몸질환의 예방 및 치료용 조성물 | |
JP3140412B2 (ja) | 牛膝または楡白皮抽出物を含有する口腔用組成物 | |
WO2024180883A1 (ja) | 抗真菌剤組成物 | |
JP7318082B2 (ja) | 糖化ストレス抑制剤 | |
Sriram et al. | Effectiveness of green tea on oral health in children. | |
WO2006110183A2 (en) | Dental formulation | |
DE102023103403A1 (de) | Mundpflegemittel mit Dimethylglycin | |
TR2022011622A2 (tr) | Propoli̇s i̇çeri̇kli̇ gargara | |
Sharma | Design and Formulation of Therapeutic Medicated Dental Pastes | |
Bhairappa | Formulation development of medicated dental pastes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOST'YU "WDS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MANASHEROV, TAMAZ OMAROVICH;MATELO, SVETLANA KONSTANTINOVNA;KUPETS, TAT'YANA VLADIMIROVNA;REEL/FRAME:035775/0155 Effective date: 20120913 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |