US20110282142A1 - Encapsulated Medical Imaging Device and Method - Google Patents
Encapsulated Medical Imaging Device and Method Download PDFInfo
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- US20110282142A1 US20110282142A1 US12/868,445 US86844510A US2011282142A1 US 20110282142 A1 US20110282142 A1 US 20110282142A1 US 86844510 A US86844510 A US 86844510A US 2011282142 A1 US2011282142 A1 US 2011282142A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00188—Optical arrangements with focusing or zooming features
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00043—Operational features of endoscopes provided with output arrangements
- A61B1/00045—Display arrangement
- A61B1/0005—Display arrangement combining images e.g. side-by-side, superimposed or tiled
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- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/00071—Insertion part of the endoscope body
- A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
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- A61B1/00064—Constructional details of the endoscope body
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- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
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- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
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- A61B1/12—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with cooling or rinsing arrangements
- A61B1/126—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with cooling or rinsing arrangements provided with means for cleaning in-use
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- A61B5/036—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs by means introduced into body tracts
Definitions
- the present invention relates to medical imaging. More particularly it relates to an encapsulated medical imaging device and method for imaging gastro intestinal tract in patients, using scanning technologies.
- the gastrointestinal tract in adult humans is about 7-9 meters in total. Presently, of these 7-9 meters only as much as about 1.2 meters, extending from the ends of the gastrointestinal (GI) tract inwardly, may be imaged in commonly practiced medical imaging techniques (colonoscopy).
- imaging techniques involve inserting a tubular optical device (such as fiber optics) into the upper digestive system through the mouth (gastroscopy) or into the colon through the anus (colonoscopy) and advancing it along the gastrointestinal tract to inspect it and detect the presence of pathologies.
- GI diseases include GI internal bleeding, inflammations of the GI tract, polyps, tapering of the GI tract, intestinal perforation, arteriovenous malformation. Internal bleeding may be caused by ulcer or varicose veins. These diseases cannot be detected in X-ray imaging or other non-invasive imaging methods until they evolve to traumatic proportion, yet even when diagnosed it is difficult to point out their exact location if that happens to fall beyond the inspectable range.
- GI tract cancers are considered major factor in older adults fatalities. Gastrointestinal malignancies are considered to be the 2 nd highest factor in male fatalities, and 3 rd highest factor in female fatalities. GI diseases may be classified with reference to their location in the GI tract and the distribution of these diseases was found to be as follows: 30 percent occurring in the esophagus, stomach and duodenum, 10 percent occurring in the small intestine and some 60 percent occurring in the large intestine.
- GI diseases Although some 80 percent of the GI diseases may supposedly be detected by colonoscopy or gastroscopy, sometimes these invasive techniques may be considered undesired. These techniques are relatively costly, requiring the presence of a several member medical team throughout the procedure. Furthermore it is statistically shown that about one in 2000 patients is prone to perforation of the GI tract caused by a sharp object (the imaging tool) during the performance of the procedure. Such an incident immediately requires surgical intervention.
- U.S. Pat. No. 5,604,531 entitled IN-VIVO VIDEO CAMERA SYSTEM, filed in 1995, and incorporated herein by reference, discloses an in-vivo video camera system and an autonomous video endoscope.
- the system includes a swallable capsule, a transmitter and a reception system.
- the swallable capsule includes a camera system and an optical system for imaging an area of interest onto the camera system.
- the transmitter transmits the output of the video camera system and the reception system receives the transmitted video output.
- U.S. Pat. No. 4,278,077 (Mitzumoto) entitled MEDICAL CAMERA SYSTEM, filed in 1979, and incorporated herein by reference, discloses a capsule-shaped miniature camera comprising at least one permanent magnet, an induction coil, a lamp serially connected to the induction coil and a shutter device.
- the induction coil induces an electromotive force when a magnetic field generated by electromagnets outside the camera acts on it.
- the electromotive force turns on the lamp and drives the shutter device.
- the video camera system of the '531 patent employs analog video and analog transmission. It is evident that it provides an image focused at a predetermined fixed distance from the optical lens and consequently, due to the poor lighting conditions within the GI tract, blurred image of objects falling outside or falling short of the focal range.
- the GI tract is composed of parts of different diameters (the esophagus, stomach, small and large intestines) it is anticipated that substantial information will be omitted or severely degraded in the image obtained by Iddan's system.
- the inside walls of the GI tract are also present “hilly” topography, and therefore pose difficulties to the imaging abilities of that system.
- an encapsulated medical imaging system comprising:
- the number of the optical setups comprises two optical setups, arranged in opposite sides of the capsule, so as to allow counter-directional viewing.
- the capsule is provided with at least one lens of a number of lenses for central view and wherein the array of microlenses is arranged in a coronal arrangement with respect to the lens, so as to provide peripheral view.
- the number of lenses comprises two lenses.
- the microlens array comprises a plurality of microlenses having different foci distributed in a known distribution, and wherein the processing means is adapted to identify and distinguish focused image data from unfocused one, disregard the unfocused data and acquire image made of focused data only.
- the illumination means comprises light emitting diodes.
- the light emitting diodes illuminate light in different frequency ranges.
- the light emitting diodes emit red, green or blue light.
- the light emitting diodes are operated so as to sequentially illuminate red green and blue light.
- the capsule is about 12-20 mm in length and about 5-7 mm in diameter.
- the capsule housing is made from a biocompatible material.
- the capsule housing is made from a dissolvable material.
- the capsule housing is made from a dissolvable material that is durable enough so that it may pass an entire GI tract without disintegrating during the estimated period of time it would normally take for the capsule to pass through.
- the capsule is internally powered.
- the capsule is externally powered.
- the capsule is inductively powered.
- the capsule is further provided with supporting means for supporting the capsule and preventing its turning over or around.
- said supporting means comprise extractable surfaces.
- the extractable surfaces are supported by arms.
- said arms are resilient.
- said arms are mechanically foldable.
- the arms are adapted to be housed in cavities provided in the housing of the capsule.
- the cavities are adapted to hold samples obtained by the arms.
- the capsule is further provided with a medical parameter sensor.
- the senor comprises a temperature sensor or a pressure sensor.
- the capsule is further provided with wiping means for wiping dirt off the optical setup.
- the wiping means comprises a wiping arm.
- an encapsulated medical imaging system comprising:
- FIG. 1 a illustrates a patient's GI tract with an encapsulated medical imaging device in accordance with the present invention traveling through it.
- FIG. 1 b illustrates a general view of an encapsulated medical imaging device in accordance with a preferred embodiment of the present invention.
- FIG. 2 a illustrates the encapsulated medical imaging device of the present invention provided with arms, shown in semi-retracted state as it travels through a small intestine.
- FIG. 2 b depicts the encapsulated medical imaging device of FIG. 2 a with its arms fully deployed as it travels through a large intestine.
- FIG. 3 a is a see-through view of a preferred embodiment of the encapsulated medical imaging device of the present invention.
- FIG. 3 b depicts the optical scheme of the device of FIG. 3 a.
- FIG. 4 a illustrates a single stretched row of the microlens array of the device of FIG. 3 a.
- FIG. 4 b illustrates fields of view of an encapsulated medical imaging device in accordance to the present invention as it travels through an intestine.
- FIGS. 5 a , 5 b and 5 c illustrate a display monitor communicating with a receiving unit of an encapsulated medical imaging device of the present invention incorporated in a vest worn by a patient.
- FIG. 6 illustrates a way to calculate the correct position of a suspected pathology detected by the encapsulated medical imaging device of the present invention.
- FIG. 7 illustrates an optional schematic configuration of the electronic system of an encapsulated medical imaging device in accordance with a preferred embodiment of the present invention.
- a main aspect of the present invention is the provision of a multi-focal hemispherical-like array, capable of capturing focused images of various portions of the inspected objects located at different distances from the capsule.
- Another main aspect of the present invention is the provision of optical array and the performance of scanning of the object rather than simply taking pictures frame-by frame.
- the resolution of the image is determined by the number of pixels, which corresponds to the number of photosensors of a optical array utilized in the present invention. Scanning allows greater resolution to be attained in comparison with video imaging (as suggested in Iddan's '531 patent), obtaining segment-by-segment image of the viewed object.
- FIG. 1 a illustrating a patient's GI tract with an encapsulated medical imaging device in accordance with the present invention traveling through it.
- the patient 30 is made to swallow the capsule 1 .
- Capsule 1 having dimensions suitable for it to be taken orally and swallowed, after having been swallowed, immediately starts transmitting image data. It is traveling through the patient's GI tract 35 , the GI tract generally comprising the esophagus 38 , stomach 32 , small intestine 34 and large intestine 36 .
- the capsule is shown located at the small intestine 34 of the patient, traveling through it and transmitting information as it travels through. Typical anticipated dimensions for the capsule would be approximately 12-20 mm in length and about 5-7 mm in diameter.
- the capsule housing is made of bio-compatible non-toxic matter.
- the encapsulated medical imaging device generally includes optical system, illumination system, optical array for obtaining digital representation of the image obtained by the optical system, electronic circuitry, and transmitting means.
- the electronic circuitry is externally powered or it may contain an internal power source.
- the capsule advances through the GI tract due to the normal intestinal action (contraction and relaxation of the GI tract muscular tissue). Due to its small size the capsule leaves the body with the excrement anally.
- the housing of the capsule is made of dissolvable material (such as the material used for producing medication capsules), so that in the event of pathological narrowing of the intestines the capsule will not be stuck there.
- dissolvable material such as the material used for producing medication capsules
- the capsule is provided with dual optics so that in fact it includes two viewing means oppositely directed. This feature is also important when the view of the front viewing optics is locally obstructed by a protrusion on the surface rising from the intestine wall (like a polyp).
- the system is supplemented by external receiving unit for receiving the data transmitted from the capsule, and a control unit for processing said data and displaying the images obtained.
- FIG. 1 b illustrates a general view of an encapsulated medical imaging device in accordance with a preferred embodiment of the present invention.
- the capsule 1 in this example having a housing 40 of elongated dimensions, comprises two optical setups, each having an axial hemispherical symmetry and located at either ends of the capsule.
- the capsule housing 40 is provided with arms 42 having flat feet 4 substantially covering cavities 44 in which the foldable arms are housed (see also FIGS. 2 a and 2 b and the corresponding description in this specification for the use and operation of these arms).
- Each end of the capsule is provided with a front lens 2 , for viewing objects in front of that end, light emitting diodes (LED) 3 for illuminating a sector in close proximity of the capsule (at least covering the whole range of the optical focused field of view of the optical components of the device), and an array of microlenses 9 made up of a multiple rows of microlenses (depicted in these Figures, for the sake of simplicity, are only four rows 5 , 6 , 7 , and 8 , but in reality a much larger number of rows of microlenses is employed).
- the optical set-up is described in detail with reference to FIGS. 3 a , 3 b , 4 a and 4 b ).
- microlens arrays are commercially available from MEMS Optical Inc (Huntsville, Ala., USA).
- the LED diodes 3 may optionally be sources of light in different frequencies, for example omitting light in the RGB ranges (i.e. one omitting red, another omitting green and, yet another omitting blue light). This is to allow scanning in different monochromatic illumination by turning on separately and sequentially each LED color and then combining the different mono-chromatic gray-scale images into one color image by the processing means of the system.
- An optional wiper 97 comprising a wiping arm traveling over the microlens array, bound by tracks 99 , so as to cover the entire microlens array, and wipe dirt off the lenses.
- a sensor 98 for sensing medical parameters such as local temperature, pressure or other parameters that communicates with the electronic control of the capsule and thus capable of transmitting the sensed data to an external receiver.
- FIG. 2 a illustrates the encapsulated medical imaging device of the present invention provided with arms, shown in semi-retracted state as it travels through a small intestine.
- the arms 42 of the device are provided so as to provide support for the device against the intestine wall 34 as the arms' feet 4 lean against the wall, and prevent the device from flopping over or turning sideways.
- the arms may be resilient or mechanically foldable and deployable so as to apply slight counter-force onto the intestine wall and enhance its supporting ability.
- the arms may alternatively of complementarily be sampling means, for sampling tissue or matter from the intestine wall. In the latter case, the arms are each adapted to be operated separately (via controlling means) and adapted to be able to be retracted into its corresponding cavity 44 so as to keep the sample inside the cavity once it is retrieved.
- FIG. 2 b depicts the encapsulated medical imaging device of FIG. 2 a with its support arms deployed as it travels through a large intestine. As the large intestine 36 is wider the arms may employ fully and reach to the intestine wall so as to prevent disorientation of the capsule.
- feet 4 may be as large as the entire housing, or substantial portions of it, thus providing larger contact surface with the intestinal wall.
- FIG. 3 a is a see-through view of a preferred embodiment of the encapsulated medical imaging device of the present invention.
- Microlens array 9 focuses light reflected form image outside the capsule. It is noted that each microlens may see different view, as some face certain sector and others face other sectors.
- An optical array is provided inside the capsule, typically comprising an array of light-sensitive receiving cells 12 . As the embodiment shown in the figures has twin optical set-up, aimed at providing two counter-directional viewing ability, two optical arrays are provided, positioned back to back so that each faces one end of the device, located in the focal plane of the corresponding optical set-up.
- the complete image imprinted on the optical array is a result of aggregation of images obtained by each microlens.
- the optical array is sampled for data by corresponding electronic circuitry 11 , which samples in a predetermined manner rows or columns or any other predetermined arrangement, and convert the analog data to digital data.
- the device is in fact scanning the image in scanning technology.
- Electronic control units 10 , 11 are each electrically communicating with the optical arrays, as well as controlling the light diodes 3 , and powering them.
- the control unit is adapted to generate transmission of data obtained by the optical array to an external receiver.
- the device with internal power source, such as a battery, or provide inductive circuitry (see for example U.S. Pat. No. 4,278,077 to Mitzumoto) that is powered by induction from an external inductive source.
- internal power source such as a battery
- inductive circuitry see for example U.S. Pat. No. 4,278,077 to Mitzumoto
- FIG. 3 b depicts the optical scheme of the device of FIG. 3 a .
- Each microlens of microlens array 9 views a small sector of the hemispherical surroundings of the device, and is focused via the optical lenses to an appropriate corresponding cell of the optical array.
- Front and back images are focused through the front and back lenses 2 onto central area 78 of the optical array, whereas the peripheral image obtained by coronal microlens array 9 is focused onto an outer annular strip portion 76 .
- the image obtained by the optics of the other end of the capsule is focused on central area 74 and peripheral area 72 of the optical array.
- the curvature of the microlens array 9 corresponds to the curvature of the front lens 2 , than a continuous image of the objects viewed outside the capsule may be obtained.
- two separate images may be displayed on an external monitor—one of the view from the front lens and one of the peripheral view viewed by the microlens array.
- a combined image may also be constructed.
- all image manipulation is carried out by an external processing unit (as described hereafter).
- FIG. 4 a illustrates a single stretched row of the microlens array of the device of FIG. 3 a .
- the microlens array comprises a plurality of microlenses 22 , arranged in a sequential manner with lenses having different focal distance distributed in that row.
- the different foci tenses are arranged so that for a particular angle of view there exist all types of the various microlens lens, and each lens is focused on a corresponding cell of the light receiving array of cells (such as photoelectric cells).
- a first group of lenses is focused on an imaginary plane 60 located at a first predetermined distance from the array.
- a second group of lenses is focused on an imaginary plane 62 located at a second predetermined distance from the array, closer than plane 60 .
- a third group of lenses is focused on an imaginary plane 64 located at a third predetermined distance from the array closer still. This way the microlens array has three focus planes and not only one.
- FIG. 4 b illustrating fields of view of an encapsulated medical imaging device in accordance to the present invention as it travels through an intestine.
- the capsule may be positioned in different distances 31 , 33 , 29 , 51 ) from the intestine wall lining. If an inspected object is located at a certain distance 31 that equals to the focal distance of one of the microlens groups, than its best available image will be acquired from that lens (in fact from a plurality of close lenses from that same group).
- the control unit of the device or the external monitoring means which receive the transmission is preferably provided with image processing software adapted to identify only focused images and disregard blurred images obtained from the other lens groups.
- the processing unit is thus adapted to identify and distinguish focused image data from unfocused one, disregard the unfocused data and acquire image made of focused data only.
- an alternative optical setup may include multiple multi-focal lenses.
- FIGS. 5 a , 5 b and 5 c illustrate a display monitor communicating with a receiving unit of an encapsulated medical imaging device of the present invention incorporated in a vest 21 worn by a patient.
- Vest 21 houses the receiving unit adapted to communicate with the capsule and may also include powering means such as inductive circuitry. It engulfs the patients' torso effectively close to the capsule as it travels through the patient's GI tract.
- the receiving unit in the vest communicates via cable or wirelessly with monitoring unit 139 .
- Monitoring unit 139 provided with display means for displaying one or several images 17 , 18 , by the encapsulated medical imaging device and/or other data 16 .
- FIG. 6 illustrates the path traveled by a capsule in a patient's small intestine.
- the device incorporates with monitoring means adapted to identify the position and location within the GI tract where an image was acquired by comparing it to a prearranged library of images, and identifying by image processing the type of environment the capsule was in when the image was acquired. It is stipulated that each portion of the GI track (i.e. esophagus, small intestine, large intestine stomach) has unique image (texture, shape, and other distinct features).
- the device By identifying the type of environment the device was in when the image was acquired and by knowing some parameters such as the sampling rate of the device, its traveling velocity within the GI tract (on average it is assumed that it would travel at the rate of 1 to 3 cm per second) it is possible to determine or at least estimate the distance of the path 94 traveled by the capsule from the last identified position 92 to the current location 96 , where a pathology was detected and viewed by the capsule.
- the software may generate a general view of the GI tract, the last image obtained as the device entered into the current type of GI tract and most recent image obtained.
- a graphic indication on the general image in the form of a cursor, arrow or any other graphical representation, may be superposed on the GI tract image indicating the device current (or recent) location. This can substantially enhance the medical team's ability to locate the exact position of the pathology found in position 96 .
- FIG. 7 illustrates an optional schematic configuration of the electronic system of an encapsulated medical imaging device in accordance with a preferred embodiment of the present invention. This is given as an example only. A person skilled in the art could easily provide other electrical configurations that would still be covered by the scope of the present invention.
- the capsule 100 generally comprises optics 110 (the lenses and optical array) communicating with a control unit 112 that transmits the digital data obtained from the optical array via communication interface 114 and antenna 116 .
- the capsule is optionally inductively powered by an inductive circuitry 111 energized externally by inductance.
- a receiver 102 (such as one incorporated in a vest—see FIGS. 5 b and 5 c ) picks up the data transmitted by an antenna 118 and communicates with a control unit 104 .
- the control unit comprises communication interface 120 , control unit 122 , processor 124 , and display means 126 (such as a monitor). It is optionally also provided with a user interface 128 , for inputting commands to the control unit.
- control unit is programmed or programmable so that physician can adjust the sampling rate of the device (i.e. the frequency of image acquiring), control the foldable arms, choose the images to be displayed or command the system to perform calculations (such as the distance traveled by the capsule inside the intestine).
- the advantages of the encapsulated imaging device of the present invention are numerous.
- the device provides high accessibility to the entire GI tract.
- the unique optical setup provides better images and a greater range for focused images.
- Optional sampling arms may be operated in-vivo and obtain samples such as biopsy, blood test or retrieve any other sample from the matter the device comes near to.
- External energizing prevents the need for internal power source that may be hazardous to the patient if the capsule disintegrates within the GI tract.
- the images may be obtained by scanning in RGB light—first scanning in red light, then scanning in green and finally in blue, each time obtaining mono-chromatic gray-scale quality images and incorporating them into a color image by the processing means of the external unit and presenting the color image on the monitor.
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Abstract
Description
- The present invention relates to medical imaging. More particularly it relates to an encapsulated medical imaging device and method for imaging gastro intestinal tract in patients, using scanning technologies.
- The gastrointestinal tract in adult humans is about 7-9 meters in total. Presently, of these 7-9 meters only as much as about 1.2 meters, extending from the ends of the gastrointestinal (GI) tract inwardly, may be imaged in commonly practiced medical imaging techniques (colonoscopy). Usually such imaging techniques involve inserting a tubular optical device (such as fiber optics) into the upper digestive system through the mouth (gastroscopy) or into the colon through the anus (colonoscopy) and advancing it along the gastrointestinal tract to inspect it and detect the presence of pathologies.
- It may take years for a colon polyp to grow and turn malignant. In the absence of neurological warning system to indicate the occurrence of malignancies in their early stages it is often that the diagnosis of gastrointestinal malignancies is too late to be cured. Problems in the GI tract are ever too often detected only when they appear in great gravity and even then detection is made possible through the discovery of secondary indications (such as fecal occult blood occurrence). Early detection can be a major factor in improving the patient's chances of survival.
- Some of the commonly occurring GI diseases include GI internal bleeding, inflammations of the GI tract, polyps, tapering of the GI tract, intestinal perforation, arteriovenous malformation. Internal bleeding may be caused by ulcer or varicose veins. These diseases cannot be detected in X-ray imaging or other non-invasive imaging methods until they evolve to traumatic proportion, yet even when diagnosed it is difficult to point out their exact location if that happens to fall beyond the inspectable range.
- GI tract cancers are considered major factor in older adults fatalities. Gastrointestinal malignancies are considered to be the 2nd highest factor in male fatalities, and 3rd highest factor in female fatalities. GI diseases may be classified with reference to their location in the GI tract and the distribution of these diseases was found to be as follows: 30 percent occurring in the esophagus, stomach and duodenum, 10 percent occurring in the small intestine and some 60 percent occurring in the large intestine.
- The inability to image the small intestine may bring about the need to perform investigative abdomen incision, sometimes just for ruling out a vague suspicion of malignancy.
- Although some 80 percent of the GI diseases may supposedly be detected by colonoscopy or gastroscopy, sometimes these invasive techniques may be considered undesired. These techniques are relatively costly, requiring the presence of a several member medical team throughout the procedure. Furthermore it is statistically shown that about one in 2000 patients is prone to perforation of the GI tract caused by a sharp object (the imaging tool) during the performance of the procedure. Such an incident immediately requires surgical intervention.
- U.S. Pat. No. 5,604,531 (Iddan et al.) entitled IN-VIVO VIDEO CAMERA SYSTEM, filed in 1995, and incorporated herein by reference, discloses an in-vivo video camera system and an autonomous video endoscope. The system includes a swallable capsule, a transmitter and a reception system. The swallable capsule includes a camera system and an optical system for imaging an area of interest onto the camera system. The transmitter transmits the output of the video camera system and the reception system receives the transmitted video output.
- U.S. Pat. No. 4,278,077 (Mitzumoto) entitled MEDICAL CAMERA SYSTEM, filed in 1979, and incorporated herein by reference, discloses a capsule-shaped miniature camera comprising at least one permanent magnet, an induction coil, a lamp serially connected to the induction coil and a shutter device. The induction coil induces an electromotive force when a magnetic field generated by electromagnets outside the camera acts on it. The electromotive force turns on the lamp and drives the shutter device.
- The video camera system of the '531 patent (Iddan) employs analog video and analog transmission. It is evident that it provides an image focused at a predetermined fixed distance from the optical lens and consequently, due to the poor lighting conditions within the GI tract, blurred image of objects falling outside or falling short of the focal range. As the GI tract is composed of parts of different diameters (the esophagus, stomach, small and large intestines) it is anticipated that substantial information will be omitted or severely degraded in the image obtained by Iddan's system. Furthermore the inside walls of the GI tract are also present “hilly” topography, and therefore pose difficulties to the imaging abilities of that system.
- It is noted that these prior art optical imaging devices are limited in their field of view as they include a single optical system and are therefore limited to one directional view. For irregular surfaces as exist in the GI tract this may result in many hidden areas that the imager will not view properly. Furthermore the possibility of the capsule flopping over or turning around is real and may hamper with the proper functionality of the device.
- It is therefore thus provided, in accordance with a preferred embodiment of the present invention, an encapsulated medical imaging system comprising:
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- a capsule of swallowable proportion comprising:
- at least one optical setup of a number of optical setups comprising an array of microlenses distributed in axial symmetry on at least a portion of the capsule so that the array of microlenses is capable of receiving light reflected from object located in at least a sector outside the capsule;
- corresponding optical array comprising an array of light sensitive cells optically communicating with said optical setup through focusing means, such that the image of the object is focused on the array of light sensitive cells;
- electronic circuitry adapted to sample image data obtained by the optical array by scanning the image and converting the image data to digital data;
- illuminating means for illuminating a sector in front the optical setup, outside the capsule;
- transmitting means communicating with said electronic circuitry, adapted to receive image digital data and transmit it to an external receiver;
- receiving means for receiving data transmitted from said capsule;
- image processing means for processing the data received by the receiving means and; and
- display means for displaying an image.
- a capsule of swallowable proportion comprising:
- Furthermore, in accordance with another preferred embodiment of the present invention, the number of the optical setups comprises two optical setups, arranged in opposite sides of the capsule, so as to allow counter-directional viewing.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule is provided with at least one lens of a number of lenses for central view and wherein the array of microlenses is arranged in a coronal arrangement with respect to the lens, so as to provide peripheral view.
- Furthermore, in accordance with another preferred embodiment of the present invention, the number of lenses comprises two lenses.
- Furthermore, in accordance with another preferred embodiment of the present invention, the microlens array comprises a plurality of microlenses having different foci distributed in a known distribution, and wherein the processing means is adapted to identify and distinguish focused image data from unfocused one, disregard the unfocused data and acquire image made of focused data only.
- Furthermore, in accordance with another preferred embodiment of the present invention, the illumination means comprises light emitting diodes.
- Furthermore, in accordance with another preferred embodiment of the present invention, the light emitting diodes illuminate light in different frequency ranges.
- Furthermore, in accordance with another preferred embodiment of the present invention, the light emitting diodes emit red, green or blue light.
- Furthermore, in accordance with another preferred embodiment of the present invention, the light emitting diodes are operated so as to sequentially illuminate red green and blue light.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule is about 12-20 mm in length and about 5-7 mm in diameter.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule housing is made from a biocompatible material.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule housing is made from a dissolvable material.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule housing is made from a dissolvable material that is durable enough so that it may pass an entire GI tract without disintegrating during the estimated period of time it would normally take for the capsule to pass through.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule is internally powered.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule is externally powered.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule is inductively powered.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule is further provided with supporting means for supporting the capsule and preventing its turning over or around.
- Furthermore, in accordance with another preferred embodiment of the present invention, said supporting means comprise extractable surfaces.
- Furthermore, in accordance with another preferred embodiment of the present invention, the extractable surfaces are supported by arms.
- Furthermore, in accordance with another preferred embodiment of the present invention, said arms are resilient.
- Furthermore, in accordance with another preferred embodiment of the present invention, said arms are mechanically foldable.
- Furthermore, in accordance with another preferred embodiment of the present invention, the arms are adapted to be housed in cavities provided in the housing of the capsule.
- Furthermore, in accordance with another preferred embodiment of the present invention, the cavities are adapted to hold samples obtained by the arms.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule is further provided with a medical parameter sensor.
- Furthermore, in accordance with another preferred embodiment of the present invention, the sensor comprises a temperature sensor or a pressure sensor.
- Furthermore, in accordance with another preferred embodiment of the present invention, the capsule is further provided with wiping means for wiping dirt off the optical setup.
- Furthermore, in accordance with another preferred embodiment of the present invention, the wiping means comprises a wiping arm.
- Finally, in accordance with another preferred embodiment of the present invention, there is provided an encapsulated medical imaging system comprising:
-
- a capsule of swallowable proportion comprising:
- at least one optical setup of a number of optical setups comprising an array of multi-focal lenses distributed in axial symmetry on at least a portion of the capsule so that the array of multi-focal lenses is capable of receiving light reflected from object located in at least a sector outside the capsule;
- corresponding optical array comprising an array of light sensitive cells optically communicating with said optical setup through focusing means, such that the image of the object is focused on the array of light sensitive cells;
- electronic circuitry adapted to sample image data obtained by the optical array by scanning the image and converting the image data to digital data;
- illuminating means for illuminating a sector in front the optical setup, outside the capsule;
- transmitting means communicating with said electronic circuitry, adapted to receive image digital data and transmit it to an external receiver;
- receiving means for receiving data transmitted from said capsule;
- image processing means for processing the data received by the receiving means and; and
display means for displaying an image.
- a capsule of swallowable proportion comprising:
- In order to better understand the present invention, and appreciate its practical applications, the following Figures are provided and referenced hereafter. It should be noted that the Figures are given as examples only and in no way limit the scope of the invention as defined in the appending Claims. Like components are denoted by like reference numerals.
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FIG. 1 a illustrates a patient's GI tract with an encapsulated medical imaging device in accordance with the present invention traveling through it. -
FIG. 1 b illustrates a general view of an encapsulated medical imaging device in accordance with a preferred embodiment of the present invention. -
FIG. 2 a illustrates the encapsulated medical imaging device of the present invention provided with arms, shown in semi-retracted state as it travels through a small intestine. -
FIG. 2 b depicts the encapsulated medical imaging device ofFIG. 2 a with its arms fully deployed as it travels through a large intestine. -
FIG. 3 a is a see-through view of a preferred embodiment of the encapsulated medical imaging device of the present invention. -
FIG. 3 b depicts the optical scheme of the device ofFIG. 3 a. -
FIG. 4 a illustrates a single stretched row of the microlens array of the device ofFIG. 3 a. -
FIG. 4 b, illustrates fields of view of an encapsulated medical imaging device in accordance to the present invention as it travels through an intestine. -
FIGS. 5 a, 5 b and 5 c illustrate a display monitor communicating with a receiving unit of an encapsulated medical imaging device of the present invention incorporated in a vest worn by a patient. -
FIG. 6 illustrates a way to calculate the correct position of a suspected pathology detected by the encapsulated medical imaging device of the present invention. -
FIG. 7 illustrates an optional schematic configuration of the electronic system of an encapsulated medical imaging device in accordance with a preferred embodiment of the present invention. - A main aspect of the present invention is the provision of a multi-focal hemispherical-like array, capable of capturing focused images of various portions of the inspected objects located at different distances from the capsule.
- Another main aspect of the present invention is the provision of optical array and the performance of scanning of the object rather than simply taking pictures frame-by frame. The resolution of the image is determined by the number of pixels, which corresponds to the number of photosensors of a optical array utilized in the present invention. Scanning allows greater resolution to be attained in comparison with video imaging (as suggested in Iddan's '531 patent), obtaining segment-by-segment image of the viewed object.
- The structure and mode of operation of the encapsulated medical imaging device of the present invention is herein explained with reference to the accompanying Figures.
- Reference is made to
FIG. 1 a, illustrating a patient's GI tract with an encapsulated medical imaging device in accordance with the present invention traveling through it. Initially thepatient 30 is made to swallow thecapsule 1.Capsule 1, having dimensions suitable for it to be taken orally and swallowed, after having been swallowed, immediately starts transmitting image data. It is traveling through the patient'sGI tract 35, the GI tract generally comprising theesophagus 38,stomach 32,small intestine 34 andlarge intestine 36. The capsule is shown located at thesmall intestine 34 of the patient, traveling through it and transmitting information as it travels through. Typical anticipated dimensions for the capsule would be approximately 12-20 mm in length and about 5-7 mm in diameter. The capsule housing is made of bio-compatible non-toxic matter. - The encapsulated medical imaging device generally includes optical system, illumination system, optical array for obtaining digital representation of the image obtained by the optical system, electronic circuitry, and transmitting means. The electronic circuitry is externally powered or it may contain an internal power source.
- The capsule advances through the GI tract due to the normal intestinal action (contraction and relaxation of the GI tract muscular tissue). Due to its small size the capsule leaves the body with the excrement anally.
- In a preferred embodiment of the present invention the housing of the capsule is made of dissolvable material (such as the material used for producing medication capsules), so that in the event of pathological narrowing of the intestines the capsule will not be stuck there. Naturally such material should be made durable enough so that it may pass the entire GI tract without disintegrating during the estimated period of time it would normally take for the capsule to pass through.
- As it may be possible for the capsule to roll over and turn around when it advances through the GI tract the capsule is provided with dual optics so that in fact it includes two viewing means oppositely directed. This feature is also important when the view of the front viewing optics is locally obstructed by a protrusion on the surface rising from the intestine wall (like a polyp).
- The system is supplemented by external receiving unit for receiving the data transmitted from the capsule, and a control unit for processing said data and displaying the images obtained.
-
FIG. 1 b illustrates a general view of an encapsulated medical imaging device in accordance with a preferred embodiment of the present invention. Thecapsule 1, in this example having a housing 40 of elongated dimensions, comprises two optical setups, each having an axial hemispherical symmetry and located at either ends of the capsule. The capsule housing 40 is provided witharms 42 havingflat feet 4 substantially coveringcavities 44 in which the foldable arms are housed (see alsoFIGS. 2 a and 2 b and the corresponding description in this specification for the use and operation of these arms). Each end of the capsule is provided with afront lens 2, for viewing objects in front of that end, light emitting diodes (LED) 3 for illuminating a sector in close proximity of the capsule (at least covering the whole range of the optical focused field of view of the optical components of the device), and an array ofmicrolenses 9 made up of a multiple rows of microlenses (depicted in these Figures, for the sake of simplicity, are only fourrows FIGS. 3 a, 3 b, 4 a and 4 b). For example, microlens arrays are commercially available from MEMS Optical Inc (Huntsville, Ala., USA). - The
LED diodes 3 may optionally be sources of light in different frequencies, for example omitting light in the RGB ranges (i.e. one omitting red, another omitting green and, yet another omitting blue light). This is to allow scanning in different monochromatic illumination by turning on separately and sequentially each LED color and then combining the different mono-chromatic gray-scale images into one color image by the processing means of the system. - An
optional wiper 97 is provided comprising a wiping arm traveling over the microlens array, bound bytracks 99, so as to cover the entire microlens array, and wipe dirt off the lenses. - Further optional feature is a
sensor 98 for sensing medical parameters such as local temperature, pressure or other parameters that communicates with the electronic control of the capsule and thus capable of transmitting the sensed data to an external receiver. -
FIG. 2 a illustrates the encapsulated medical imaging device of the present invention provided with arms, shown in semi-retracted state as it travels through a small intestine. Thearms 42 of the device are provided so as to provide support for the device against theintestine wall 34 as the arms'feet 4 lean against the wall, and prevent the device from flopping over or turning sideways. The arms may be resilient or mechanically foldable and deployable so as to apply slight counter-force onto the intestine wall and enhance its supporting ability. The arms may alternatively of complementarily be sampling means, for sampling tissue or matter from the intestine wall. In the latter case, the arms are each adapted to be operated separately (via controlling means) and adapted to be able to be retracted into its correspondingcavity 44 so as to keep the sample inside the cavity once it is retrieved. -
FIG. 2 b depicts the encapsulated medical imaging device ofFIG. 2 a with its support arms deployed as it travels through a large intestine. As thelarge intestine 36 is wider the arms may employ fully and reach to the intestine wall so as to prevent disorientation of the capsule. - In another preferred embodiment of the present invention,
feet 4 may be as large as the entire housing, or substantial portions of it, thus providing larger contact surface with the intestinal wall. -
FIG. 3 a is a see-through view of a preferred embodiment of the encapsulated medical imaging device of the present invention.Microlens array 9 focuses light reflected form image outside the capsule. It is noted that each microlens may see different view, as some face certain sector and others face other sectors. An optical array is provided inside the capsule, typically comprising an array of light-sensitive receiving cells 12. As the embodiment shown in the figures has twin optical set-up, aimed at providing two counter-directional viewing ability, two optical arrays are provided, positioned back to back so that each faces one end of the device, located in the focal plane of the corresponding optical set-up. The complete image imprinted on the optical array is a result of aggregation of images obtained by each microlens. The optical array is sampled for data by correspondingelectronic circuitry 11, which samples in a predetermined manner rows or columns or any other predetermined arrangement, and convert the analog data to digital data. The device is in fact scanning the image in scanning technology. - Optionally it may be required to place appropriate correction
optical lenses Electronic control units light diodes 3, and powering them. The control unit is adapted to generate transmission of data obtained by the optical array to an external receiver. - It is possible to provide the device with internal power source, such as a battery, or provide inductive circuitry (see for example U.S. Pat. No. 4,278,077 to Mitzumoto) that is powered by induction from an external inductive source.
-
FIG. 3 b depicts the optical scheme of the device ofFIG. 3 a. Each microlens ofmicrolens array 9 views a small sector of the hemispherical surroundings of the device, and is focused via the optical lenses to an appropriate corresponding cell of the optical array. Front and back images are focused through the front andback lenses 2 ontocentral area 78 of the optical array, whereas the peripheral image obtained bycoronal microlens array 9 is focused onto an outerannular strip portion 76. Identically, the image obtained by the optics of the other end of the capsule is focused oncentral area 74 andperipheral area 72 of the optical array. - It is stipulated that if the curvature of the
microlens array 9 corresponds to the curvature of thefront lens 2, than a continuous image of the objects viewed outside the capsule may be obtained. Alternatively two separate images may be displayed on an external monitor—one of the view from the front lens and one of the peripheral view viewed by the microlens array. A combined image may also be constructed. In a preferred embodiment of the present invention, all image manipulation is carried out by an external processing unit (as described hereafter). -
FIG. 4 a illustrates a single stretched row of the microlens array of the device ofFIG. 3 a. In a preferred embodiment of the present invention the microlens array comprises a plurality ofmicrolenses 22, arranged in a sequential manner with lenses having different focal distance distributed in that row. The different foci tenses are arranged so that for a particular angle of view there exist all types of the various microlens lens, and each lens is focused on a corresponding cell of the light receiving array of cells (such as photoelectric cells). A first group of lenses is focused on animaginary plane 60 located at a first predetermined distance from the array. A second group of lenses is focused on animaginary plane 62 located at a second predetermined distance from the array, closer thanplane 60. A third group of lenses is focused on animaginary plane 64 located at a third predetermined distance from the array closer still. This way the microlens array has three focus planes and not only one. - The virtue of this feature can be appreciated by referring to
FIG. 4 b, illustrating fields of view of an encapsulated medical imaging device in accordance to the present invention as it travels through an intestine. - As the capsule arrives (position 1 a) some portions of the
intestine walls 39 are hidden as aprotrusion 37 blocks its field of view. In fact the inside walls of the intestine are very irregular. Chyme (mixed food and digestive juices) is pushed through the small intestine through muscular contractions. During these contractions the chyme, having the consistency of runny applesauce, is squished into the lining of the wall of the small intestine. Nutrients are absorbed via osmosis by the blood vessels in the mesentery and absorbed through osmosis by the blood vessels attached to the outside of the small intestine. The lining of the intestine is hilly so as to present large surface area for that osmosis to take place. However when the capsule crosses over to position 1 b its rear optics allows viewing that hidden area and thus the limitations of the prior art devices concerning their field of view is greatly reduced. - It is clearly seen that the capsule may be positioned in
different distances 31, 33, 29, 51) from the intestine wall lining. If an inspected object is located at a certain distance 31 that equals to the focal distance of one of the microlens groups, than its best available image will be acquired from that lens (in fact from a plurality of close lenses from that same group). The control unit of the device or the external monitoring means which receive the transmission is preferably provided with image processing software adapted to identify only focused images and disregard blurred images obtained from the other lens groups. Thus the device is capable of providing clear and focused images of objects at various distances from the device. The processing unit is thus adapted to identify and distinguish focused image data from unfocused one, disregard the unfocused data and acquire image made of focused data only. - Similarly, in another preferred embodiment of the present invention, an alternative optical setup may include multiple multi-focal lenses.
-
FIGS. 5 a, 5 b and 5 c illustrate a display monitor communicating with a receiving unit of an encapsulated medical imaging device of the present invention incorporated in avest 21 worn by a patient.Vest 21 houses the receiving unit adapted to communicate with the capsule and may also include powering means such as inductive circuitry. It engulfs the patients' torso effectively close to the capsule as it travels through the patient's GI tract. The receiving unit in the vest communicates via cable or wirelessly withmonitoring unit 139.Monitoring unit 139 provided with display means for displaying one orseveral images other data 16. -
FIG. 6 illustrates the path traveled by a capsule in a patient's small intestine. In another preferred embodiment of the present invention the device incorporates with monitoring means adapted to identify the position and location within the GI tract where an image was acquired by comparing it to a prearranged library of images, and identifying by image processing the type of environment the capsule was in when the image was acquired. It is stipulated that each portion of the GI track (i.e. esophagus, small intestine, large intestine stomach) has unique image (texture, shape, and other distinct features). By identifying the type of environment the device was in when the image was acquired and by knowing some parameters such as the sampling rate of the device, its traveling velocity within the GI tract (on average it is assumed that it would travel at the rate of 1 to 3 cm per second) it is possible to determine or at least estimate the distance of thepath 94 traveled by the capsule from the last identifiedposition 92 to thecurrent location 96, where a pathology was detected and viewed by the capsule. The software may generate a general view of the GI tract, the last image obtained as the device entered into the current type of GI tract and most recent image obtained. A graphic indication on the general image, in the form of a cursor, arrow or any other graphical representation, may be superposed on the GI tract image indicating the device current (or recent) location. This can substantially enhance the medical team's ability to locate the exact position of the pathology found inposition 96. -
FIG. 7 illustrates an optional schematic configuration of the electronic system of an encapsulated medical imaging device in accordance with a preferred embodiment of the present invention. This is given as an example only. A person skilled in the art could easily provide other electrical configurations that would still be covered by the scope of the present invention. - The
capsule 100 generally comprises optics 110 (the lenses and optical array) communicating with acontrol unit 112 that transmits the digital data obtained from the optical array viacommunication interface 114 andantenna 116. The capsule is optionally inductively powered by aninductive circuitry 111 energized externally by inductance. A receiver 102 (such as one incorporated in a vest—seeFIGS. 5 b and 5 c) picks up the data transmitted by anantenna 118 and communicates with acontrol unit 104. The control unit comprisescommunication interface 120,control unit 122,processor 124, and display means 126 (such as a monitor). It is optionally also provided with auser interface 128, for inputting commands to the control unit. In a preferred embodiment of the present invention the control unit is programmed or programmable so that physician can adjust the sampling rate of the device (i.e. the frequency of image acquiring), control the foldable arms, choose the images to be displayed or command the system to perform calculations (such as the distance traveled by the capsule inside the intestine). - The advantages of the encapsulated imaging device of the present invention are numerous. The device provides high accessibility to the entire GI tract. The unique optical setup provides better images and a greater range for focused images. Optional sampling arms may be operated in-vivo and obtain samples such as biopsy, blood test or retrieve any other sample from the matter the device comes near to. External energizing prevents the need for internal power source that may be hazardous to the patient if the capsule disintegrates within the GI tract.
- In a preferred embodiment of the present invention the images may be obtained by scanning in RGB light—first scanning in red light, then scanning in green and finally in blue, each time obtaining mono-chromatic gray-scale quality images and incorporating them into a color image by the processing means of the external unit and presenting the color image on the monitor.
- Note that the system described in the specification and figures is mainly designed to obtain black and white images, but these images are remarkably clear and distinct and the anticipated resolution is much greater than that of video images.
- It should be clear that the description of the embodiments and attached Figures set forth in this specification serves only for a better understanding of the invention, without limiting its scope as covered by the following Claims.
- It should also be clear that a person skilled in the art, after reading the present specification could make adjustments or amendments to the attached Figures and above described embodiments that would still be covered by the following Claims.
Claims (28)
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120238810A1 (en) * | 2010-09-28 | 2012-09-20 | Olympus Medical Systems Corp. | Image display apparatus and capsule endoscope system |
Families Citing this family (188)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8636648B2 (en) | 1999-03-01 | 2014-01-28 | West View Research, Llc | Endoscopic smart probe |
US10973397B2 (en) | 1999-03-01 | 2021-04-13 | West View Research, Llc | Computerized information collection and processing apparatus |
IL130486A (en) * | 1999-06-15 | 2005-08-31 | Given Imaging Ltd | Optical system |
US7813789B2 (en) * | 1999-06-15 | 2010-10-12 | Given Imaging Ltd. | In-vivo imaging device, optical system and method |
US7996067B2 (en) * | 1999-06-15 | 2011-08-09 | Given Imaging Ltd. | In-vivo imaging device, optical system and method |
US7140766B2 (en) | 1999-08-04 | 2006-11-28 | Given Imaging Ltd. | Device, system and method for temperature sensing in an in-vivo device |
IL132944A (en) | 1999-11-15 | 2009-05-04 | Arkady Glukhovsky | Method for activating an image collecting process |
IL134017A (en) * | 2000-01-13 | 2008-04-13 | Capsule View Inc | Camera for viewing inside intestines |
JP2001231187A (en) * | 2000-02-15 | 2001-08-24 | Asahi Optical Co Ltd | Power supply system |
IL177381A0 (en) | 2000-03-08 | 2006-12-10 | Given Imaging Ltd | A device for in vivo imaging |
US6709387B1 (en) | 2000-05-15 | 2004-03-23 | Given Imaging Ltd. | System and method for controlling in vivo camera capture and display rate |
IL143418A (en) | 2000-05-31 | 2004-09-27 | Given Imaging Ltd | Measurement of electrical characteristics of tissue |
US7555333B2 (en) | 2000-06-19 | 2009-06-30 | University Of Washington | Integrated optical scanning image acquisition and display |
WO2002036007A1 (en) * | 2000-10-30 | 2002-05-10 | Motorola, Inc. | Ingestible capsule video transmitting fluorescent images |
US7553276B2 (en) | 2001-01-16 | 2009-06-30 | Given Imaging Ltd. | Method and device for imaging body lumens |
US7468044B2 (en) * | 2001-01-16 | 2008-12-23 | Given Imaging Ltd. | Device, system and method for determining in vivo body lumen conditions |
US20020109774A1 (en) * | 2001-01-16 | 2002-08-15 | Gavriel Meron | System and method for wide field imaging of body lumens |
US7119814B2 (en) * | 2001-05-18 | 2006-10-10 | Given Imaging Ltd. | System and method for annotation on a moving image |
IL143259A (en) | 2001-05-20 | 2006-08-01 | Given Imaging Ltd | Method for moving an object through the colon |
US7727169B1 (en) | 2001-06-11 | 2010-06-01 | Given Imaging, Ltd. | Device for in vivo sensing |
US7998065B2 (en) | 2001-06-18 | 2011-08-16 | Given Imaging Ltd. | In vivo sensing device with a circuit board having rigid sections and flexible sections |
US6939292B2 (en) | 2001-06-20 | 2005-09-06 | Olympus Corporation | Capsule type endoscope |
US7585283B2 (en) * | 2001-07-12 | 2009-09-08 | Given Imaging Ltd. | Device and method for examining a body lumen |
AU2002317466B2 (en) * | 2001-07-12 | 2008-02-28 | Given Imaging Ltd | Device and method for examining a body lumen |
US6934573B1 (en) | 2001-07-23 | 2005-08-23 | Given Imaging Ltd. | System and method for changing transmission from an in vivo sensing device |
US9113846B2 (en) | 2001-07-26 | 2015-08-25 | Given Imaging Ltd. | In-vivo imaging device providing data compression |
US9149175B2 (en) | 2001-07-26 | 2015-10-06 | Given Imaging Ltd. | Apparatus and method for light control in an in-vivo imaging device |
US6951536B2 (en) * | 2001-07-30 | 2005-10-04 | Olympus Corporation | Capsule-type medical device and medical system |
JP4794765B2 (en) * | 2001-07-30 | 2011-10-19 | オリンパス株式会社 | Capsule endoscope |
JP4393866B2 (en) | 2001-08-02 | 2010-01-06 | ギブン イメージング リミテッド | In vivo imaging capsule |
US7347817B2 (en) | 2001-08-02 | 2008-03-25 | Given Imaging Ltd. | Polarized in vivo imaging device, system and method |
US8428685B2 (en) | 2001-09-05 | 2013-04-23 | Given Imaging Ltd. | System and method for magnetically maneuvering an in vivo device |
DE10146197B4 (en) * | 2001-09-14 | 2016-04-21 | Karl Storz Gmbh & Co. Kg | Intracorporeal probe for the analysis or diagnosis of, for example, hollow organs and body cavities in the human or animal body |
IL161058A0 (en) | 2001-09-24 | 2004-08-31 | Given Imaging Ltd | System and method for controlling a device in vivo |
JP4643089B2 (en) * | 2001-09-27 | 2011-03-02 | オリンパス株式会社 | Capsule medical device |
IL153510A0 (en) * | 2001-12-18 | 2003-07-06 | Given Imaging Ltd | Device, system and method for capturing in-vivo images with three-dimensional aspects |
IL147221A (en) * | 2001-12-20 | 2010-11-30 | Given Imaging Ltd | Device, system and method for image based size analysis |
US6958034B2 (en) | 2002-02-11 | 2005-10-25 | Given Imaging Ltd. | Self propelled device |
US6939290B2 (en) | 2002-02-11 | 2005-09-06 | Given Imaging Ltd | Self propelled device having a magnetohydrodynamic propulsion system |
US7474327B2 (en) | 2002-02-12 | 2009-01-06 | Given Imaging Ltd. | System and method for displaying an image stream |
US8022980B2 (en) | 2002-02-12 | 2011-09-20 | Given Imaging Ltd. | System and method for displaying an image stream |
JP4234605B2 (en) | 2002-02-12 | 2009-03-04 | ギブン イメージング リミテッド | System and method for displaying an image stream |
US7485093B2 (en) | 2002-04-25 | 2009-02-03 | Given Imaging Ltd. | Device and method for in-vivo sensing |
US7662094B2 (en) | 2002-05-14 | 2010-02-16 | Given Imaging Ltd. | Optical head assembly with dome, and device for use thereof |
US7708705B2 (en) | 2002-07-03 | 2010-05-04 | Given Imaging Ltd. | System and method for sensing in-vivo stress and pressure |
FR2842721B1 (en) * | 2002-07-25 | 2005-06-24 | Assist Publ Hopitaux De Paris | METHOD FOR NON-INVASIVE AND AMBULATORY EXPLORATION OF DIGESTIVE TRACTION AND TRANSIT AND CORRESPONDING SYSTEM |
US6776165B2 (en) * | 2002-09-12 | 2004-08-17 | The Regents Of The University Of California | Magnetic navigation system for diagnosis, biopsy and drug delivery vehicles |
US7662093B2 (en) | 2002-09-30 | 2010-02-16 | Given Imaging, Ltd. | Reduced size imaging device |
US8449452B2 (en) | 2002-09-30 | 2013-05-28 | Given Imaging Ltd. | In-vivo sensing system |
JP4746876B2 (en) | 2002-10-15 | 2011-08-10 | ギブン イメージング リミテッド | Apparatus, system and method for transferring a signal to a mobile device |
US6936003B2 (en) | 2002-10-29 | 2005-08-30 | Given Imaging Ltd | In-vivo extendable element device and system, and method of use |
JP4089778B2 (en) * | 2002-11-07 | 2008-05-28 | 株式会社アイデンビデオトロニクス | Energy supply equipment |
US7118529B2 (en) | 2002-11-29 | 2006-10-10 | Given Imaging, Ltd. | Method and apparatus for transmitting non-image information via an image sensor in an in vivo imaging system |
US7634305B2 (en) | 2002-12-17 | 2009-12-15 | Given Imaging, Ltd. | Method and apparatus for size analysis in an in vivo imaging system |
WO2004058041A2 (en) | 2002-12-26 | 2004-07-15 | Given Imaging Ltd. | Immobilizable in vivo sensing device |
US7833151B2 (en) | 2002-12-26 | 2010-11-16 | Given Imaging Ltd. | In vivo imaging device with two imagers |
JP2004298560A (en) * | 2003-04-01 | 2004-10-28 | Olympus Corp | Capsule endoscope system |
IL161096A (en) | 2003-03-27 | 2008-08-07 | Given Imaging Ltd | Device, system and method for measuring a gradient in-vivo |
US20040193023A1 (en) * | 2003-03-28 | 2004-09-30 | Aris Mardirossian | System, method and apparatus for monitoring recording and reporting physiological data |
IL155175A (en) | 2003-03-31 | 2012-01-31 | Given Imaging Ltd | Diagnostic device using data compression |
AU2007203429B2 (en) * | 2003-04-25 | 2009-06-11 | Olympus Corporation | Radio-type in-subject information acquisition system, device for introduction into subject, and outside-subject device |
US7214182B2 (en) | 2003-04-25 | 2007-05-08 | Olympus Corporation | Wireless in-vivo information acquiring system, body-insertable device, and external device |
JP4550048B2 (en) * | 2003-05-01 | 2010-09-22 | ギブン イメージング リミテッド | Panorama field of view imaging device |
EP1641390A4 (en) | 2003-06-26 | 2008-06-04 | Given Imaging Ltd | Methods, device and system for in vivo detection |
IL162740A (en) | 2003-06-26 | 2010-06-16 | Given Imaging Ltd | Device, method and system for reduced transmission imaging |
AU2004254764B2 (en) * | 2003-07-02 | 2010-12-09 | Given Imaging Ltd. | Imaging sensor array and device and method for use thereof |
JP4526245B2 (en) * | 2003-07-04 | 2010-08-18 | オリンパス株式会社 | Video signal processing device |
US7460896B2 (en) | 2003-07-29 | 2008-12-02 | Given Imaging Ltd. | In vivo device and method for collecting oximetry data |
DE10336734A1 (en) * | 2003-08-11 | 2005-03-10 | Siemens Ag | Tissue anchor for endorobots |
JP4253550B2 (en) * | 2003-09-01 | 2009-04-15 | オリンパス株式会社 | Capsule endoscope |
US7604589B2 (en) * | 2003-10-01 | 2009-10-20 | Given Imaging, Ltd. | Device, system and method for determining orientation of in-vivo devices |
WO2005031650A1 (en) * | 2003-10-02 | 2005-04-07 | Given Imaging Ltd. | System and method for presentation of data streams |
US20050075537A1 (en) * | 2003-10-06 | 2005-04-07 | Eastman Kodak Company | Method and system for real-time automatic abnormality detection for in vivo images |
DE10346678A1 (en) * | 2003-10-08 | 2005-05-12 | Siemens Ag | Endoscopy device comprising an endoscopy capsule or an endoscopy head with an image recording device and imaging method for such an endoscopy device |
EP1690490B1 (en) * | 2003-11-11 | 2012-04-18 | Olympus Corporation | Capsule type medical device system |
JP4009581B2 (en) | 2003-11-18 | 2007-11-14 | オリンパス株式会社 | Capsule medical system |
EP2649931B1 (en) * | 2003-12-05 | 2017-02-01 | Olympus Corporation | Display processing device |
WO2005058137A2 (en) | 2003-12-12 | 2005-06-30 | University Of Washington | Catheterscope 3d guidance and interface system |
US20050137468A1 (en) * | 2003-12-18 | 2005-06-23 | Jerome Avron | Device, system, and method for in-vivo sensing of a substance |
JP4594616B2 (en) * | 2003-12-19 | 2010-12-08 | オリンパス株式会社 | Capsule medical system |
US8639314B2 (en) | 2003-12-24 | 2014-01-28 | Given Imaging Ltd. | Device, system and method for in-vivo imaging of a body lumen |
US7647090B1 (en) | 2003-12-30 | 2010-01-12 | Given Imaging, Ltd. | In-vivo sensing device and method for producing same |
WO2005062717A2 (en) | 2003-12-31 | 2005-07-14 | Given Imaging Ltd. | In-vivo sensing device with detachable part |
EP1699530B1 (en) | 2003-12-31 | 2012-07-04 | Given Imaging Ltd. | System and method for displaying an image stream |
US7635346B2 (en) * | 2004-01-09 | 2009-12-22 | G. I. View Ltd. | Pressure-propelled system for body lumen |
ITPI20040008A1 (en) * | 2004-02-17 | 2004-05-17 | Dino Accoto | ROBOTIC CAPSULE FOR INTRA-BODY BIOMEDICAL APPLICATIONS |
US20050196023A1 (en) * | 2004-03-01 | 2005-09-08 | Eastman Kodak Company | Method for real-time remote diagnosis of in vivo images |
JP2005253798A (en) * | 2004-03-12 | 2005-09-22 | Olympus Corp | Internally introduced device in subject |
WO2005087083A1 (en) * | 2004-03-18 | 2005-09-22 | Yiqun Lu | A kind of capsule pattern endoscopic |
US7605852B2 (en) | 2004-05-17 | 2009-10-20 | Micron Technology, Inc. | Real-time exposure control for automatic light control |
US7970455B2 (en) * | 2004-05-20 | 2011-06-28 | Spectrum Dynamics Llc | Ingestible device platform for the colon |
WO2005120325A2 (en) * | 2004-06-07 | 2005-12-22 | Given Imaging Ltd | Method, system and device for suction biopsy |
US20050288555A1 (en) * | 2004-06-28 | 2005-12-29 | Binmoeller Kenneth E | Methods and devices for illuminating, vievwing and monitoring a body cavity |
US7336833B2 (en) * | 2004-06-30 | 2008-02-26 | Given Imaging, Ltd. | Device, system, and method for reducing image data captured in-vivo |
US7596403B2 (en) * | 2004-06-30 | 2009-09-29 | Given Imaging Ltd. | System and method for determining path lengths through a body lumen |
US8500630B2 (en) | 2004-06-30 | 2013-08-06 | Given Imaging Ltd. | In vivo device with flexible circuit board and method for assembly thereof |
JP4578873B2 (en) | 2004-07-08 | 2010-11-10 | オリンパス株式会社 | Intra-subject introduction apparatus and intra-subject introduction system |
JP4598456B2 (en) * | 2004-08-06 | 2010-12-15 | オリンパス株式会社 | In-subject image acquisition system and in-subject introduction device |
DE602005027223D1 (en) * | 2004-08-30 | 2011-05-12 | Olympus Corp | POSITION SENSOR |
US8585584B2 (en) * | 2004-10-11 | 2013-11-19 | Nitesh Ratnakar | Dual view endoscope |
IL171772A (en) * | 2004-11-04 | 2009-11-18 | Given Imaging Ltd | Apparatus and method for receiving device selection and combining |
US7486981B2 (en) | 2004-11-15 | 2009-02-03 | Given Imaging Ltd. | System and method for displaying an image stream |
JP4598498B2 (en) * | 2004-11-29 | 2010-12-15 | オリンパス株式会社 | Intra-subject introduction device |
DE102005008501A1 (en) * | 2005-02-24 | 2006-08-31 | Siemens Ag | Camera for creation of images during endoscopic action, comprising facet optics with multitude of micro lenses |
US7530948B2 (en) * | 2005-02-28 | 2009-05-12 | University Of Washington | Tethered capsule endoscope for Barrett's Esophagus screening |
US20060217593A1 (en) * | 2005-03-24 | 2006-09-28 | Zvika Gilad | Device, system and method of panoramic multiple field of view imaging |
IL167782A (en) | 2005-03-31 | 2011-12-29 | Given Imaging Ltd | Antenna for in-vivo imaging system |
IL174531A0 (en) * | 2005-04-06 | 2006-08-20 | Given Imaging Ltd | System and method for performing capsule endoscopy diagnosis in remote sites |
US20060232668A1 (en) * | 2005-04-18 | 2006-10-19 | Given Imaging Ltd. | Color filter array with blue elements |
JP4709579B2 (en) * | 2005-04-26 | 2011-06-22 | オリンパスメディカルシステムズ株式会社 | Capsule endoscope |
IL177045A (en) | 2005-07-25 | 2012-12-31 | Daniel Gat | Device, system and method of receiving and recording and displaying in-vivo data with user entered data |
US7567692B2 (en) | 2005-09-30 | 2009-07-28 | Given Imaging Ltd. | System and method for detecting content in-vivo |
US8423123B2 (en) | 2005-09-30 | 2013-04-16 | Given Imaging Ltd. | System and method for in-vivo feature detection |
US7577283B2 (en) | 2005-09-30 | 2009-08-18 | Given Imaging Ltd. | System and method for detecting content in-vivo |
US8537203B2 (en) | 2005-11-23 | 2013-09-17 | University Of Washington | Scanning beam with variable sequential framing using interrupted scanning resonance |
JP4855771B2 (en) * | 2005-12-20 | 2012-01-18 | オリンパスメディカルシステムズ株式会社 | In-vivo image capturing apparatus and in-vivo image capturing system |
US9320417B2 (en) | 2005-12-29 | 2016-04-26 | Given Imaging Ltd. | In-vivo optical imaging device with backscatter blocking |
US20070156051A1 (en) * | 2005-12-29 | 2007-07-05 | Amit Pascal | Device and method for in-vivo illumination |
US20070167834A1 (en) * | 2005-12-29 | 2007-07-19 | Amit Pascal | In-vivo imaging optical device and method |
EP1983882A2 (en) * | 2006-01-30 | 2008-10-29 | Vision Sciences Inc. | Controllable endoscope |
EP1991314A2 (en) | 2006-03-03 | 2008-11-19 | University of Washington | Multi-cladding optical fiber scanner |
US8098295B2 (en) | 2006-03-06 | 2012-01-17 | Given Imaging Ltd. | In-vivo imaging system device and method with image stream construction using a raw images |
US9084547B2 (en) | 2006-03-30 | 2015-07-21 | Given Imaging Ltd. | System and method for checking the status of an in-vivo imaging device |
JP2009532082A (en) * | 2006-03-30 | 2009-09-10 | ギブン イメージング リミテッド | In-vivo detection device and method of communication between imager and imager processor |
KR101047253B1 (en) * | 2006-04-14 | 2011-07-06 | 올림푸스 메디칼 시스템즈 가부시키가이샤 | Image display |
WO2007128084A2 (en) * | 2006-04-21 | 2007-11-15 | Nasirov, Fizuli Akber Oglu | The controllable microcapsule type robot-endoscope |
WO2007144879A1 (en) * | 2006-06-12 | 2007-12-21 | Given Imaging Ltd. | Device, system and method for measurement and analysis of contractile activity |
US8043209B2 (en) | 2006-06-13 | 2011-10-25 | Given Imaging Ltd. | System and method for transmitting the content of memory storage in an in-vivo sensing device |
JP2008012094A (en) * | 2006-07-06 | 2008-01-24 | Kenichi Katsu | Capsule endoscope |
JP2009544392A (en) * | 2006-07-24 | 2009-12-17 | フィリップス インテレクチュアル プロパティ アンド スタンダーズ ゲーエムベーハー | Capsule camera with variable irradiation of surrounding tissue |
EP2054852B1 (en) * | 2006-08-21 | 2010-06-23 | STI Medical Systems, LLC | Computer aided analysis using video from endoscopes |
US7761134B2 (en) * | 2006-10-20 | 2010-07-20 | Given Imaging Ltd. | System and method for modeling a tracking curve of an in vivo device |
US20100149183A1 (en) * | 2006-12-15 | 2010-06-17 | Loewke Kevin E | Image mosaicing systems and methods |
US8273015B2 (en) * | 2007-01-09 | 2012-09-25 | Ethicon Endo-Surgery, Inc. | Methods for imaging the anatomy with an anatomically secured scanner assembly |
US8801606B2 (en) * | 2007-01-09 | 2014-08-12 | Ethicon Endo-Surgery, Inc. | Method of in vivo monitoring using an imaging system including scanned beam imaging unit |
DE102007008756A1 (en) * | 2007-02-22 | 2008-08-28 | Siemens Ag | Measuring head i.e. micromechanical measuring head, for optical endoscope, has image sensor formed for producing electrical image signals of image, where optics and image sensor form micro-lens system |
US9730573B2 (en) * | 2007-03-20 | 2017-08-15 | Given Imaging Ltd. | Narrow band in-vivo imaging device |
US20080262295A1 (en) * | 2007-03-22 | 2008-10-23 | Amar Kendale | Methods and devices for viewing anatomic structure |
JP5019589B2 (en) * | 2007-03-28 | 2012-09-05 | 富士フイルム株式会社 | Capsule endoscope, capsule endoscope system, and method for operating capsule endoscope |
US8840566B2 (en) | 2007-04-02 | 2014-09-23 | University Of Washington | Catheter with imaging capability acts as guidewire for cannula tools |
US20100113874A1 (en) * | 2007-04-04 | 2010-05-06 | Marco Quirini | Teleoperated endoscopic capsule |
US7952718B2 (en) | 2007-05-03 | 2011-05-31 | University Of Washington | High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor |
JP2009061097A (en) * | 2007-09-06 | 2009-03-26 | Olympus Medical Systems Corp | Capsule endoscope |
US20090105532A1 (en) * | 2007-10-22 | 2009-04-23 | Zvika Gilad | In vivo imaging device and method of manufacturing thereof |
US8529441B2 (en) | 2008-02-12 | 2013-09-10 | Innurvation, Inc. | Ingestible endoscopic optical scanning device |
JP2008183451A (en) * | 2008-05-01 | 2008-08-14 | Olympus Corp | Introduction-into-subject device |
CA2723363A1 (en) * | 2008-05-07 | 2009-11-12 | The Smartpill Corporation | Method of determining the slow wave of a gastrointestinal tract |
US20090312627A1 (en) * | 2008-06-16 | 2009-12-17 | Matott Laura A | Radio-labeled ingestible capsule |
US8515507B2 (en) | 2008-06-16 | 2013-08-20 | Given Imaging Ltd. | Device and method for detecting in-vivo pathology |
US9538937B2 (en) | 2008-06-18 | 2017-01-10 | Covidien Lp | System and method of evaluating a subject with an ingestible capsule |
US8235888B2 (en) | 2008-07-08 | 2012-08-07 | Olympus Medical Systems Corp. | System for guiding capsule medical device |
JP4695678B2 (en) * | 2008-08-04 | 2011-06-08 | オリンパス株式会社 | Capsule medical device |
CN101721194B (en) * | 2008-10-14 | 2011-11-09 | 鸿富锦精密工业(深圳)有限公司 | Capsule endoscope and method for manufacturing lenses thereof |
TWI401054B (en) * | 2008-10-24 | 2013-07-11 | Wcube Co Ltd | Capsule endoscope and method for manufacturing lens thereof |
JP2012511961A (en) * | 2008-12-11 | 2012-05-31 | プロテウス バイオメディカル インコーポレイテッド | Judgment of digestive tract function using portable visceral electrical recording system and method using the same |
JP2010194099A (en) * | 2009-02-25 | 2010-09-09 | Fujifilm Corp | Capsule type endoscope |
DE102009013354B4 (en) * | 2009-03-16 | 2011-02-17 | Siemens Aktiengesellschaft | Coil system, medical device and method for non-contact magnetic navigation of a magnetic body in a workspace |
US7931149B2 (en) | 2009-05-27 | 2011-04-26 | Given Imaging Ltd. | System for storing and activating an in vivo imaging capsule |
US8516691B2 (en) | 2009-06-24 | 2013-08-27 | Given Imaging Ltd. | Method of assembly of an in vivo imaging device with a flexible circuit board |
DE112010004507B4 (en) | 2009-11-20 | 2023-05-25 | Given Imaging Ltd. | System and method for controlling power consumption of an in vivo device |
US8945010B2 (en) | 2009-12-23 | 2015-02-03 | Covidien Lp | Method of evaluating constipation using an ingestible capsule |
WO2011135573A1 (en) | 2010-04-28 | 2011-11-03 | Given Imaging Ltd. | System and method for displaying portions of in-vivo images |
US8768024B1 (en) | 2010-06-01 | 2014-07-01 | Given Imaging Ltd. | System and method for real time detection of villi texture in an image stream of the gastrointestinal tract |
CN103209632B (en) | 2010-11-16 | 2017-03-15 | 基文影像公司 | For executing the in-vivo imaging apparatus and method of spectrum analyses |
JP5675388B2 (en) * | 2011-01-19 | 2015-02-25 | オリンパスメディカルシステムズ株式会社 | Medical equipment |
US8929629B1 (en) | 2011-06-29 | 2015-01-06 | Given Imaging Ltd. | Method and system for image-based ulcer detection |
US8934722B2 (en) | 2011-09-19 | 2015-01-13 | Given Imaging Ltd. | System and method for classification of image data items based on indirect user input |
JP2012086029A (en) * | 2011-12-01 | 2012-05-10 | Olympus Medical Systems Corp | Capsule endoscope |
US8861783B1 (en) | 2011-12-30 | 2014-10-14 | Given Imaging Ltd. | System and method for detection of content in an image stream of the gastrointestinal tract |
US8923585B1 (en) | 2012-01-31 | 2014-12-30 | Given Imaging Ltd. | Method and system for image-based ulcer detection |
US9770588B2 (en) * | 2012-04-30 | 2017-09-26 | Carnegie Mellon University | Ingestible, electrical device for stimulating tissues in a gastrointestinal tract of an organism |
US9545192B2 (en) | 2012-05-04 | 2017-01-17 | Given Imaging Ltd. | System and method for automatic navigation of a capsule based on image stream captured in-vivo |
US10405734B2 (en) | 2012-06-29 | 2019-09-10 | Given Imaging Ltd. | System and method for displaying an image stream |
US9955922B2 (en) * | 2012-11-16 | 2018-05-01 | Lowell Zane Shuck | Capsule device and methodology for discovery of gut microbe roles in diseases with origin in gut |
US9215997B2 (en) * | 2012-11-16 | 2015-12-22 | L. Zane Shuck | In vivo technology system for human gut research, diagnostics and treatment |
US20140243598A1 (en) * | 2013-02-25 | 2014-08-28 | Corning Incorporated | Optical probe delivery and retrieval systems and methods |
US9324145B1 (en) | 2013-08-08 | 2016-04-26 | Given Imaging Ltd. | System and method for detection of transitions in an image stream of the gastrointestinal tract |
US10070932B2 (en) | 2013-08-29 | 2018-09-11 | Given Imaging Ltd. | System and method for maneuvering coils power optimization |
US11609689B2 (en) | 2013-12-11 | 2023-03-21 | Given Imaging Ltd. | System and method for controlling the display of an image stream |
US9342881B1 (en) | 2013-12-31 | 2016-05-17 | Given Imaging Ltd. | System and method for automatic detection of in vivo polyps in video sequences |
EP3110303A2 (en) | 2014-02-26 | 2017-01-04 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Large field of view multi-camera endoscopic apparatus with omni-directional illumination |
DK3197336T3 (en) * | 2014-09-25 | 2021-01-18 | Progenity Inc | Electromechanical pellet device with localization properties |
US10045758B2 (en) * | 2014-11-26 | 2018-08-14 | Visura Technologies, LLC | Apparatus, systems and methods for proper transesophageal echocardiography probe positioning by using camera for ultrasound imaging |
EP3223713B1 (en) | 2014-11-26 | 2023-08-16 | Visura Technologies, Inc. | Apparatus for proper transesophageal echocardiography probe positioning by using camera for ultrasound imaging |
US10299745B2 (en) * | 2014-12-29 | 2019-05-28 | Loyola University Of Chicago | Traceable devices for gastrointestinal use and methods of use and manufacturing the same |
US10143364B2 (en) * | 2015-07-23 | 2018-12-04 | Ankon Technologies Co., Ltd | Controlled image capturing method including position tracking and system used therein |
WO2019226744A1 (en) * | 2018-05-22 | 2019-11-28 | Velis Christopher J P | Power supplies and methods of using miniaturized intra-body controllable medical device |
KR20220038806A (en) | 2018-09-25 | 2022-03-29 | 미라키 이노베이션 씽크 탱크 엘엘씨 | In-vivo robotic imaging, sensing and deployment devices and methods for medical scaffolds |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5865750A (en) * | 1997-05-07 | 1999-02-02 | General Electric Company | Method and apparatus for enhancing segmentation in three-dimensional ultrasound imaging |
US5879284A (en) * | 1996-12-10 | 1999-03-09 | Fuji Photo Film Co., Ltd. | Endoscope |
US6240312B1 (en) * | 1997-10-23 | 2001-05-29 | Robert R. Alfano | Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment |
US20010051766A1 (en) * | 1999-03-01 | 2001-12-13 | Gazdzinski Robert F. | Endoscopic smart probe and method |
US6449006B1 (en) * | 1992-06-26 | 2002-09-10 | Apollo Camera, Llc | LED illumination system for endoscopic cameras |
US7869856B2 (en) * | 2000-01-13 | 2011-01-11 | Moshe Refael | Encapsulated medical imaging device and method |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US48A (en) * | 1836-10-11 | Turnout fob | ||
JPS4831554B1 (en) | 1968-12-24 | 1973-09-29 | ||
US3645653A (en) * | 1970-06-01 | 1972-02-29 | Valcor Eng Corp | Pump |
JPS49130235A (en) | 1973-04-16 | 1974-12-13 | ||
JPS5720168Y2 (en) | 1973-05-31 | 1982-04-30 | ||
JPS5519124A (en) | 1978-07-27 | 1980-02-09 | Olympus Optical Co | Camera system for medical treatment |
US4803992A (en) | 1980-10-28 | 1989-02-14 | Lemelson Jerome H | Electro-optical instruments and methods for producing same |
US5993378A (en) * | 1980-10-28 | 1999-11-30 | Lemelson; Jerome H. | Electro-optical instruments and methods for treating disease |
JPS5861723A (en) * | 1981-10-09 | 1983-04-12 | オリンパス光学工業株式会社 | Endoscope |
JPS60104915A (en) | 1983-11-11 | 1985-06-10 | Fuji Photo Optical Co Ltd | Endoscope |
DE3440177A1 (en) | 1984-11-02 | 1986-05-15 | Friedrich Dipl.-Ing. 8031 Eichenau Hilliges | Television recording and replay device for endoscopy on human and animal bodies |
JPS6476822A (en) | 1987-09-17 | 1989-03-22 | Toshiba Corp | Endoscopic apparatus for observing total digestive tract |
US4846154A (en) | 1988-06-13 | 1989-07-11 | Macanally Richard B | Dual view endoscope |
JPH039705A (en) | 1989-06-06 | 1991-01-17 | Sanyo Electric Co Ltd | Automatic rice cooker |
DE3921233A1 (en) | 1989-06-28 | 1991-02-14 | Storz Karl Gmbh & Co | ENDOSCOPE WITH A VIDEO DEVICE AT THE DISTAL END |
US5681260A (en) * | 1989-09-22 | 1997-10-28 | Olympus Optical Co., Ltd. | Guiding apparatus for guiding an insertable body within an inspected object |
JPH03159629A (en) | 1989-11-20 | 1991-07-09 | Hiroaki Kumagai | Apparatus for diagnosing digestive tract |
US5430475A (en) * | 1990-06-29 | 1995-07-04 | Olympus Optical Co., Ltd. | Electronic endoscope apparatus having micro array on photoelectric conversion surface |
JPH04144533A (en) | 1990-10-05 | 1992-05-19 | Olympus Optical Co Ltd | Endoscope |
JP2768029B2 (en) * | 1991-02-19 | 1998-06-25 | 日新電機株式会社 | Digestive system diagnostic device |
US5662587A (en) * | 1992-09-16 | 1997-09-02 | Cedars Sinai Medical Center | Robotic endoscopy |
JP3279409B2 (en) | 1993-10-18 | 2002-04-30 | オリンパス光学工業株式会社 | Medical capsule device |
IL108352A (en) * | 1994-01-17 | 2000-02-29 | Given Imaging Ltd | In vivo video camera system |
US5547455A (en) | 1994-03-30 | 1996-08-20 | Medical Media Systems | Electronically steerable endoscope |
US5653677A (en) | 1994-04-12 | 1997-08-05 | Fuji Photo Optical Co. Ltd | Electronic endoscope apparatus with imaging unit separable therefrom |
JP3159629B2 (en) | 1994-10-07 | 2001-04-23 | 昭道 小出 | Ultrasonic processing device with drill delivery mechanism and linear drill used for the same |
JPH08248326A (en) | 1995-03-10 | 1996-09-27 | Olympus Optical Co Ltd | Stereoscopic endoscope |
DE69610491T2 (en) | 1995-04-07 | 2001-02-08 | Minnesota Mining And Mfg. Co., Saint Paul | ELECTRONIC GOODS MONITORING SYSTEM WITH ADAPTIVE FILTERING AND DIGITAL DETECTING |
US5833603A (en) * | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
GB9619470D0 (en) | 1996-09-18 | 1996-10-30 | Univ London | Imaging apparatus |
US5993278A (en) | 1998-02-27 | 1999-11-30 | The Regents Of The University Of California | Passivation of quartz for halogen-containing light sources |
IL126727A (en) * | 1998-10-22 | 2006-12-31 | Given Imaging Ltd | Method for delivering a device to a target location |
US7116352B2 (en) | 1999-02-25 | 2006-10-03 | Visionsense Ltd. | Capsule |
JP3462795B2 (en) | 1999-06-07 | 2003-11-05 | ペンタックス株式会社 | Swallowable endoscope device |
JP3490932B2 (en) * | 1999-06-07 | 2004-01-26 | ペンタックス株式会社 | Swallowable endoscope device |
US6949154B2 (en) | 2001-07-28 | 2005-09-27 | Boehringer Ingelheim Pharma Kg | Method and apparatus for sealing medicinal capsules |
JP4144533B2 (en) | 2004-02-24 | 2008-09-03 | ソニー株式会社 | Playback apparatus and method |
-
2000
- 2000-01-13 IL IL134017A patent/IL134017A/en not_active IP Right Cessation
-
2001
- 2001-01-10 US US10/169,615 patent/US7869856B2/en not_active Expired - Fee Related
- 2001-01-10 AU AU2001223932A patent/AU2001223932A1/en not_active Abandoned
- 2001-01-10 JP JP2001551367A patent/JP5041645B2/en not_active Expired - Fee Related
- 2001-01-10 WO PCT/IL2001/000020 patent/WO2001050941A2/en active Search and Examination
- 2001-01-10 EP EP01900234.4A patent/EP1251777B1/en not_active Expired - Lifetime
- 2001-01-10 CA CA002397160A patent/CA2397160A1/en not_active Abandoned
-
2010
- 2010-08-25 US US12/868,445 patent/US20110282142A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6449006B1 (en) * | 1992-06-26 | 2002-09-10 | Apollo Camera, Llc | LED illumination system for endoscopic cameras |
US5879284A (en) * | 1996-12-10 | 1999-03-09 | Fuji Photo Film Co., Ltd. | Endoscope |
US5865750A (en) * | 1997-05-07 | 1999-02-02 | General Electric Company | Method and apparatus for enhancing segmentation in three-dimensional ultrasound imaging |
US6240312B1 (en) * | 1997-10-23 | 2001-05-29 | Robert R. Alfano | Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment |
US20010051766A1 (en) * | 1999-03-01 | 2001-12-13 | Gazdzinski Robert F. | Endoscopic smart probe and method |
US6984205B2 (en) * | 1999-03-01 | 2006-01-10 | Gazdzinski Robert F | Endoscopic smart probe and method |
US7869856B2 (en) * | 2000-01-13 | 2011-01-11 | Moshe Refael | Encapsulated medical imaging device and method |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120238810A1 (en) * | 2010-09-28 | 2012-09-20 | Olympus Medical Systems Corp. | Image display apparatus and capsule endoscope system |
US8986198B2 (en) * | 2010-09-28 | 2015-03-24 | Olympus Medical Systems Corp. | Image display apparatus and capsule endoscope system |
Also Published As
Publication number | Publication date |
---|---|
JP5041645B2 (en) | 2012-10-03 |
CA2397160A1 (en) | 2001-07-19 |
WO2001050941A3 (en) | 2001-12-06 |
WO2001050941A2 (en) | 2001-07-19 |
AU2001223932A1 (en) | 2001-07-24 |
IL134017A0 (en) | 2001-04-30 |
JP2003526413A (en) | 2003-09-09 |
EP1251777A2 (en) | 2002-10-30 |
EP1251777A4 (en) | 2007-11-14 |
US7869856B2 (en) | 2011-01-11 |
US20030208107A1 (en) | 2003-11-06 |
IL134017A (en) | 2008-04-13 |
EP1251777B1 (en) | 2014-01-01 |
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