US20110269719A1 - Pharmaceutical compositions with phosphonium antimicrobial agents - Google Patents

Pharmaceutical compositions with phosphonium antimicrobial agents Download PDF

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Publication number
US20110269719A1
US20110269719A1 US13/093,995 US201113093995A US2011269719A1 US 20110269719 A1 US20110269719 A1 US 20110269719A1 US 201113093995 A US201113093995 A US 201113093995A US 2011269719 A1 US2011269719 A1 US 2011269719A1
Authority
US
United States
Prior art keywords
composition
phosphonium
pharmaceutical composition
chloride
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/093,995
Other languages
English (en)
Inventor
Masood A. Chowhan
Wesley Wehsin Han
L. Wayne Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Research LLC
Original Assignee
Alcon Research LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Research LLC filed Critical Alcon Research LLC
Priority to US13/093,995 priority Critical patent/US20110269719A1/en
Assigned to ALCON RESEARCH, LTD. reassignment ALCON RESEARCH, LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SCHNEIDER, L. WAYNE, CHOWHAN, MASOOD A., HAN, WESLEY WEHSIN
Publication of US20110269719A1 publication Critical patent/US20110269719A1/en
Priority to US14/085,230 priority patent/US9694021B2/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • the phosphonium antimicrobial agent of the present application can be used in combination with other preservatives such as benzalkonium chloride (BAK), polymeric quaternary ammonium compound, polyhexamethyl biguanide (PHMB), or the like.
  • BAK benzalkonium chloride
  • PHMB polyhexamethyl biguanide
  • the phosphonium antimicrobial agent of the present application can be the sole or only preservative within the compositions of the present invention.
  • composition of the present invention can also include borate, polyol or both for buffering purposes and/or for enhancement of anti-microbial activity.
  • borate shall refer to boric acid, salts of boric acid, borate derivatives and other pharmaceutically acceptable borates, or combinations thereof. Most suitable are: boric acid, sodium borate, potassium borate, calcium borate, magnesium borate, manganese borate, and other such borate salts.
  • polyol includes any compound having at least one hydroxyl group on each of two adjacent carbon atoms that are not in trans configuration relative to each other.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
US13/093,995 2010-04-28 2011-04-26 Pharmaceutical compositions with phosphonium antimicrobial agents Abandoned US20110269719A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/093,995 US20110269719A1 (en) 2010-04-28 2011-04-26 Pharmaceutical compositions with phosphonium antimicrobial agents
US14/085,230 US9694021B2 (en) 2010-04-28 2013-11-20 Pharmaceutical compositions with phosphonium antimicrobial agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32881510P 2010-04-28 2010-04-28
US13/093,995 US20110269719A1 (en) 2010-04-28 2011-04-26 Pharmaceutical compositions with phosphonium antimicrobial agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/085,230 Continuation US9694021B2 (en) 2010-04-28 2013-11-20 Pharmaceutical compositions with phosphonium antimicrobial agents

Publications (1)

Publication Number Publication Date
US20110269719A1 true US20110269719A1 (en) 2011-11-03

Family

ID=44123163

Family Applications (2)

Application Number Title Priority Date Filing Date
US13/093,995 Abandoned US20110269719A1 (en) 2010-04-28 2011-04-26 Pharmaceutical compositions with phosphonium antimicrobial agents
US14/085,230 Active 2031-09-11 US9694021B2 (en) 2010-04-28 2013-11-20 Pharmaceutical compositions with phosphonium antimicrobial agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
US14/085,230 Active 2031-09-11 US9694021B2 (en) 2010-04-28 2013-11-20 Pharmaceutical compositions with phosphonium antimicrobial agents

Country Status (15)

Country Link
US (2) US20110269719A1 (zh)
EP (1) EP2563375B1 (zh)
JP (2) JP2013525439A (zh)
KR (1) KR20130093468A (zh)
CN (1) CN102858352B (zh)
AU (1) AU2011245442B2 (zh)
BR (1) BR112012027432A2 (zh)
CA (1) CA2795369A1 (zh)
DK (1) DK2563375T3 (zh)
ES (1) ES2494668T3 (zh)
MX (1) MX2012012089A (zh)
PL (1) PL2563375T3 (zh)
PT (1) PT2563375E (zh)
SI (1) SI2563375T1 (zh)
WO (1) WO2011137090A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9694021B2 (en) 2010-04-28 2017-07-04 Alcon Research, Ltd Pharmaceutical compositions with phosphonium antimicrobial agents

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3136811A1 (en) * 2019-04-16 2020-10-22 Lunella Biotech, Inc. Alkyl-tpp compounds for mitochondria targeting and anti-cancer treatments
CN110226604B (zh) * 2019-07-05 2020-08-21 中国科学院南京土壤研究所 一种磁性生物质炭-季鏻盐杀菌材料、制备及使用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939554B2 (en) * 2002-02-05 2005-09-06 Michigan Biotechnology Institute Antimicrobial polymer

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US3281365A (en) 1963-12-23 1966-10-25 Monsanto Co Antiseptic detergent compositions
US3294632A (en) * 1964-08-31 1966-12-27 Hooker Chemical Corp Controlling bacteria on textile materials with reaction products of tetrakis (alpha-hydroxyorgano) phosphonium halides combined with formaldehyde source materials
US3998754A (en) 1974-07-31 1976-12-21 Exxon Research And Engineering Company Surface active quaternary higher dialkyl phosphonium salts
US4188380A (en) 1974-07-31 1980-02-12 Exxon Research & Engineering Co. Surface active quaternary higher dialkyl phosphonium salt biocides and intermediates
EP0066544B1 (de) 1981-05-30 1985-01-09 Ciba-Geigy Ag Wasseraufbereitung
EP0139404B1 (en) 1983-08-26 1988-02-03 Albright & Wilson Limited Biocidal water treatment
DE3628801A1 (de) * 1986-08-25 1988-03-03 Henkel Kgaa Antimikrobiell wirksame gemische
EP0526654B1 (en) * 1991-02-21 1996-12-04 Nippon Chemical Industrial Company Limited Antibacterial
DE69413790T2 (de) 1993-07-14 1999-02-25 Nippon Chemical Ind Antibakterielles polymer, kontaktlinse und kontaktlinsenpflegeprodukt
CN1159158A (zh) 1994-05-20 1997-09-10 诺瓦瓦克斯有限公司 抗菌水包油乳液
WO1995031996A1 (en) 1994-05-25 1995-11-30 Milkhaus Lab Materials and methods for treatment of plaquing diseases
JPH11147918A (ja) * 1997-11-14 1999-06-02 Menicon Co Ltd 水可溶性抗菌ポリマーおよびそれからなるコンタクトレンズ用液剤
JPH11271695A (ja) 1998-03-25 1999-10-08 Menicon Co Ltd コンタクトレンズ用液剤
JP4268703B2 (ja) * 1998-08-03 2009-05-27 株式会社メニコン コンタクトレンズ用流通保存液およびそれを用いたコンタクトレンズの流通保存方法
CA2308896A1 (en) 2000-05-18 2001-11-18 Allan James Robertson Phosphonium salts
JP2003137712A (ja) * 2001-11-02 2003-05-14 Hakuto Co Ltd デンプン配合組成物の腐敗抑制方法
US6579859B1 (en) * 2002-06-10 2003-06-17 Ge Betz, Inc. Control of protozoa and protozoan cysts that harbor legionella
US7125967B2 (en) * 2003-10-08 2006-10-24 Adjuvant Pharmaceuticals, Llc Water-soluble chitosan having low endotoxin concentration and methods for making and using the same
GB0403773D0 (en) * 2004-02-20 2004-03-24 Rhodia Consumer Specialities L Embedded biocide
CN100443580C (zh) * 2006-03-21 2008-12-17 侯丽君 隐形眼镜清洗液组合物及其用途
UA106606C2 (uk) * 2009-03-16 2014-09-25 Родія Оперейшнс Стабілізована біоцидна композиція
EP2563375B1 (en) 2010-04-28 2014-06-25 Alcon Research, Ltd. Pharmaceutical compositions with phosphonium antimicrobial agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939554B2 (en) * 2002-02-05 2005-09-06 Michigan Biotechnology Institute Antimicrobial polymer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9694021B2 (en) 2010-04-28 2017-07-04 Alcon Research, Ltd Pharmaceutical compositions with phosphonium antimicrobial agents

Also Published As

Publication number Publication date
JP2013525439A (ja) 2013-06-20
JP2016041773A (ja) 2016-03-31
SI2563375T1 (sl) 2014-09-30
US20140080793A1 (en) 2014-03-20
AU2011245442A1 (en) 2012-10-25
EP2563375B1 (en) 2014-06-25
WO2011137090A1 (en) 2011-11-03
CN102858352B (zh) 2015-05-06
CN102858352A (zh) 2013-01-02
US9694021B2 (en) 2017-07-04
EP2563375A1 (en) 2013-03-06
ES2494668T3 (es) 2014-09-15
BR112012027432A2 (pt) 2016-08-09
KR20130093468A (ko) 2013-08-22
AU2011245442B2 (en) 2015-01-22
PT2563375E (pt) 2014-09-02
MX2012012089A (es) 2012-11-29
PL2563375T3 (pl) 2014-11-28
DK2563375T3 (da) 2014-08-18
CA2795369A1 (en) 2011-11-03

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Legal Events

Date Code Title Description
AS Assignment

Owner name: ALCON RESEARCH, LTD., TEXAS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:CHOWHAN, MASOOD A.;HAN, WESLEY WEHSIN;SCHNEIDER, L. WAYNE;SIGNING DATES FROM 20110325 TO 20110408;REEL/FRAME:026180/0500

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION