US20100185157A1 - Plunger Assembly for Syringe - Google Patents

Plunger Assembly for Syringe Download PDF

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Publication number
US20100185157A1
US20100185157A1 US12/668,812 US66881208A US2010185157A1 US 20100185157 A1 US20100185157 A1 US 20100185157A1 US 66881208 A US66881208 A US 66881208A US 2010185157 A1 US2010185157 A1 US 2010185157A1
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US
United States
Prior art keywords
piston
syringe
depression
plunger rod
male screw
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/668,812
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English (en)
Inventor
Hideaki Kawamura
Hiroshi Togashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daikyo Seiko Ltd
Original Assignee
Daikyo Seiko Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daikyo Seiko Ltd filed Critical Daikyo Seiko Ltd
Assigned to DAIKYO SEIKO, LTD. reassignment DAIKYO SEIKO, LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KAWAMURA, HIDEAKI, TOGASHI, HIROSHI
Publication of US20100185157A1 publication Critical patent/US20100185157A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod

Definitions

  • the present invention relates to a plunger assembly for a syringe for pushing out a Medicinal solution retained in a syringe barrel.
  • a plunger assembly for a syringe is composed of a piston which is slidably fitted into a syringe barrel and a plunger rod which is screwed into an axis apart of the piston.
  • the piston and the plunger rod are generally assembled in a fitting manner of a male screw and a female screw.
  • a piston which slides in a syringe barrel is formed by a rubber as a main component.
  • silicone oil has been applied to the surface of the piston that is provided in some cases.
  • the present patent applicant and so on has provided a laminate piston in which a tetrafluoroethylene resin film, an ethylene tetrafluoroethylene resin film, or a high molecular weight polyethylene resin film is laminated on the surface of a rubber piston.
  • an actual field site of a medical treatment involves an operation of not only pushing out a piston but also pulling out a piston, more specifically an operation of confirming an introduction of a needle and filling with a medicinal solution in a syringe barrel by making a piston together with a plunger rod move in reverse to the base end side of a syringe barrel.
  • a syringe has a small capacity in order to lessen a burden of the patient, and a diameter of a syringe barrel has a tendency to be decreased.
  • a diameter of a piston is required to be extremely decreased.
  • a depression a hole for a fitting
  • the present invention was made in consideration of such conditions, and an object of the present invention is to provide a plunger assembly for a syringe in which a force to pushing a piston is hardly applied in the case in which a piston and a plunger rod are engaged with each other, a piston is engaged with a plunger rod in a slidable manner after an engagement, and a piston can be held at the leading end of a plunger rod without fault and the piston together with the plunger rod can be pulled out in an integrated manner even in the case in which a pulling out operation is carried out in order to fill with a medicinal solution in a syringe barrel by making the piston together with the plunger rod move in reverse to the base end side of the syringe barrel for an extremely thin syringe having a small capacity in particular.
  • the plunger assembly for a syringe in accordance with the present invention is characterized in that the piston is a laminate piston in which a resin film is laminated on the surface thereof.
  • the surface of the piston in the present specification includes not only a peripheral surface of the piston, that is, a surface that comes into contact with a chemical solution, and a sliding surface of the piston, but also a surface of the depression.
  • the above laminate piston represents pistons related to three modes of a piston in which only a peripheral surface is laminated, a piston in which only a surface of the depression is laminated, and a piston in which both the peripheral surface and the depression are laminated.
  • the plunger rod is fitted to the piston in a state that the male screw formed at an end part of the plunger rod comes into contact with an inner wall of the depression of the piston in a sliding manner or that the male screw is screwed into the depression, thereby preventing the piston from being dropped out of the plunger rod.
  • FIG. 1 is a cross-sectional view showing a fitting state of a syringe barrel that configures a syringe in accordance with an embodiment of the present invention and a plunger assembly for a syringe in accordance with the present invention.
  • FIG. 2 is a half cross-sectional view showing a laminate piston of the plunger assembly for a syringe shown in FIG. 1 .
  • FIG. 3 is an elevation view showing a plunger rod of the plunger assembly for a syringe shown in FIG. 1 .
  • FIG. 4 is an elevation view showing a plunger assembly for a syringe in the case in which a plunger rod is attached to the laminate piston shown in FIG. 2 .
  • FIG. 5 is an elevation view showing another example of a plunger rod shown in FIG. 3 .
  • FIG. 1 is a cross-sectional view showing a plunger assembly for a syringe in accordance with an embodiment of the present invention.
  • a plunger assembly 10 for a syringe in accordance with an embodiment of the present invention is composed of a piston 4 that is inserted into a syringe barrel 2 in a slidable manner and a plunger rod 6 that is attached into the depression of the piston 4 .
  • a resin film is laminated to a peripheral surface of a rubber piston, and a depression 8 is formed in an axial direction on the base end side.
  • an outer diameter of the piston 4 is in the range of 3.0 to 5.5 mm
  • an overall length is in the range of 4.0 to 7.0 mm
  • an inner diameter of the depression 8 is in the range of 1.0 to 4.0 mm.
  • a male screw 12 that is inserted into the depression 8 of the piston 4 is formed at the leading end of a rod body 6 a.
  • a pressing flange 14 is formed on the rear end side the plunger rod 6 .
  • the male screw 12 is composed of a thread crest 12 a and a thread gullet 12 b in a spiral shape, and a diameter of the thread crest 12 a is larger than an inner diameter of the depression 8 of the piston 4 . Consequently, by pressing the male screw 12 into the depression 8 of the piston 4 , the male screw 12 of the plunger rod 6 is cut into the depression 8 of the piston 4 that is relatively soft.
  • the male screw 12 of the plunger rod 6 shown in FIG. 3 is disposed opposite to the base end side of the piston 4 shown in FIG. 2 at first, and the male screw 12 of the plunger rod 6 is screwed into the depression 8 of the piston 4 while a slight force is applied.
  • the thread crest 12 a extending in a screw pattern for the male screw 12 is fitted to the inner wall of the depression 8 and is cut into the inner wall, whereby the piston 4 can be engaged with the plunger rod 6 without fault.
  • the relationship between an inner diameter of the depression 8 of the piston 4 and a diameter of the thread crest 12 a depends on an inner diameter of the syringe barrel 2 and a shape and a material of the piston 4 . It is preferable that a diameter of the thread crest 12 a of the male screw 12 is larger than an inner diameter of the depression 8 of the piston 4 by the range of 10 to 25%. In the case in which a degree is 10% or less, the piston 4 is easily dropped out of the plunger rod 6 undesirably. On the other hand, in the case in which a degree is 25% or larger, a sliding resistance of the piston 4 is increased undesirably.
  • the piston 4 is easily dropped out of the plunger rod 6 on pulling out.
  • a surface of the depression 8 is hardened due to a lamination of a film, the piston 4 is hard to be dropped out. Consequently, in the case in which a film is laminated on the depression 8 and a length of the depression 8 is larger, the piston 4 is hard to be dropped out in comparison with the case in which a film is not laminated on the depression 8 .
  • a length of the depression 8 is 70% or less of a length of the piston 4 .
  • a sealing performance of the piston 4 is deteriorated, and a molding performance of the male screw 12 of the plunger rod 6 is deteriorated disadvantageously.
  • the plunger assembly 10 for a syringe in accordance with an embodiment of the present invention, it is unnecessary that a female screw is formed in the depression 8 of the piston 4 . Consequently, the present invention can be applied to an extra thin piston 4 .
  • the present invention can be applied to an extra thin syringe piston that has a small capacity of 5 ml or less and that is hard to have a substantive female screw inside the piston, for instance a syringe piston that has a small capacity of 0.5 ml or less and that has a syringe barrel inner diameter of 5 mm or less.
  • the piston 4 can be engaged with the plunger rod 6 without fault by the male screw 12 of the plunger rod 6 . Consequently, in the case in which an operation of pulling out the piston 4 is carried out, the piston 4 can be prevented from being dropped out of the plunger rod 6 .
  • a plastic is used in general, and there can be mentioned for instance a cyclic olefin series resin, a cyclic olefin ethylene copolymer, a polyethylene terephthalate series resin, a polystyrene resin, and a polyethylene terephthalate resin.
  • a cyclic olefin series resin and a cyclic olefin ethylene copolymer that have a high transparency and an excellent heat resistance property and that have no chemical interaction with a pharmacological product (for instance, those used for a hygiene container disclosed in Patent Publication No. 2914826).
  • any one of a rubber material and an elastomer material, which have been used for a production of a piston, can be used, and the material is not restricted in particular.
  • a butyl series rubber such as a butyl rubber, a chlorinated butyl rubber, a brominated butyl rubber, and a divinylbenzene copolymerization butyl rubber
  • a conjugated diene series rubber such as a polyisoprene rubber, (high to low cis 1, 4 bonding), a polyisobutylene rubber, a polybutadiene rubber (high to low cis 1, 4 bonding), and a styrene-butadiene copolymerization rubber
  • EPDM ethylene-propylene-diene terpolymerization rubber
  • an elastomer an olefin series copolymer rubber (elastomer) and/or olefin series plastics can be mentioned for instance.
  • the piston 4 in accordance with the present invention is produced by using an elastomer or a crosslinking rubber composition (compound) that is obtained by kneading the above rubber material and a compounding agent such as a crosslinking agent, a filler and/or a reinforcing agent, a coloring agent, and an age resister as needed and by a publicly known molding method such as a compression molding and an injection molding for a piston.
  • a compounding agent to be used is not restricted in particular, and can be a compounding agent that has been used in producing a rubber stopper or a piston for a pharmacological product or medical treatment tools.
  • the piston 4 for a syringe in accordance with the present invention is a laminate piston, a surface that comes into contact with a chemical solution or a sliding surface of the piston is laminated by a plastic film made of a material such as a fluorine resin, ultrahigh molecular weight polyethylene, polyethylene, polypropylene, polyester, and nylon.
  • a fluorine resin such as polyethylene, polypropylene, polyester, and nylon.
  • the periphery of the piston is laminated or coated by a fluorine resin film.
  • a fluorine resin in accordance with the present invention there can be selected for instance PTFE (polytetrafluoroethylene), ETFE (ethylene-tetrafluoroethylene copolymer), PFE (perfluoro alkoxyalkane), PFA (perfluoro ethylene propene copolymer), PVDF (polyvinylidene fluoride), and an alloy of those and other polymer as needed. From a point of view of a sliding property and a low reactivity, PTFE (polytetrafluoroethylene) is preferable in particular.
  • the depression 8 of the piston 4 for a syringe in accordance with the present invention is laminated or coated with a film as a point of view of a screwing property and an engaging property.
  • a material of a film that is laminated or coated on the depression 8 there can be used for instance a fluorine resin, ultrahigh molecular weight polyethylene, polyethylene, polypropylene, polyester, and nylon similarly to other parts of the piston 4 as described above. From a point of view of a suitable sliding property, a low reactivity, and a cost, ultrahigh molecular weight polyethylene is preferable in particular.
  • a material of a film that is laminated or coated on the depression 8 and a material of a film that is laminated or coated on other parts of the piston 4 can be the same or can be different from each other.
  • a syringe in which a plunger assembly for a syringe in accordance with the present invention is used includes a syringe having two rooms as disclosed in Japanese Patent Application Laid-Open Publication No. 9-308688 in addition to a normal syringe having one room.
  • the thread crest 12 a in a spiral shape is formed on the male screw 12 of the plunger rod 6 .
  • the male screw 12 continues in a spiral shape, and a plurality of ring bodies can be simply disposed in a protruding manner at a predetermined interval as shown in FIG. 5 .
  • a male screw in accordance with the present invention includes a protruding body other than a so-called thread crest that continues in a spiral shape.
  • the screw shape as shown in FIG. 3 is preferable in particular from a point of view of a friction and damage to an inner wall of the depression of the piston.
  • a plunger assembly for a syringe in which a piston having a small diameter is used is shown in the above embodiment. However, this does not prevent the present invention from being applied to a plunger assembly for a syringe in which a piston having a large diameter is used.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US12/668,812 2007-07-13 2008-06-27 Plunger Assembly for Syringe Abandoned US20100185157A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007-184327 2007-07-13
JP2007184327 2007-07-13
PCT/JP2008/061749 WO2009011214A1 (ja) 2007-07-13 2008-06-27 注射器用プランジャアセンブリ

Publications (1)

Publication Number Publication Date
US20100185157A1 true US20100185157A1 (en) 2010-07-22

Family

ID=40259552

Family Applications (1)

Application Number Title Priority Date Filing Date
US12/668,812 Abandoned US20100185157A1 (en) 2007-07-13 2008-06-27 Plunger Assembly for Syringe

Country Status (4)

Country Link
US (1) US20100185157A1 (ja)
EP (1) EP2174681A4 (ja)
JP (1) JPWO2009011214A1 (ja)
WO (1) WO2009011214A1 (ja)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD668760S1 (en) * 2011-06-17 2012-10-09 Daikyo Seiko, Ltd. Syringe barrel
US9272095B2 (en) 2011-04-01 2016-03-01 Sio2 Medical Products, Inc. Vessels, contact surfaces, and coating and inspection apparatus and methods
US9458536B2 (en) 2009-07-02 2016-10-04 Sio2 Medical Products, Inc. PECVD coating methods for capped syringes, cartridges and other articles
US9554968B2 (en) 2013-03-11 2017-01-31 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging
US9572526B2 (en) 2009-05-13 2017-02-21 Sio2 Medical Products, Inc. Apparatus and method for transporting a vessel to and from a PECVD processing station
US9664626B2 (en) 2012-11-01 2017-05-30 Sio2 Medical Products, Inc. Coating inspection method
US9662450B2 (en) 2013-03-01 2017-05-30 Sio2 Medical Products, Inc. Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus
US9764093B2 (en) 2012-11-30 2017-09-19 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition
US9863042B2 (en) 2013-03-15 2018-01-09 Sio2 Medical Products, Inc. PECVD lubricity vessel coating, coating process and apparatus providing different power levels in two phases
US9878101B2 (en) 2010-11-12 2018-01-30 Sio2 Medical Products, Inc. Cyclic olefin polymer vessels and vessel coating methods
US9903782B2 (en) 2012-11-16 2018-02-27 Sio2 Medical Products, Inc. Method and apparatus for detecting rapid barrier coating integrity characteristics
US9937099B2 (en) 2013-03-11 2018-04-10 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging with low oxygen transmission rate
US10201660B2 (en) 2012-11-30 2019-02-12 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition on medical syringes, cartridges, and the like
US10369292B2 (en) 2016-01-15 2019-08-06 W. L. Gore & Associates, Inc. Syringe plunger assemblies
DE112010004275B4 (de) 2009-10-23 2019-08-14 Flextronics Ap, Llc Verfahren und Vorrichtung zum Formpressen von thermoplastischen Materialien mit hoher Geschwindigkeit und niedrigem Pressdruck

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9597458B2 (en) * 2009-10-29 2017-03-21 W. L. Gore & Associates, Inc. Fluoropolymer barrier materials for containers
US10471212B2 (en) 2009-10-29 2019-11-12 W. L. Gore & Associates, Inc. Silicone free drug delivery devices
WO2012007246A1 (en) * 2010-07-13 2012-01-19 Novo Nordisk A/S A piston rod foot
US11612697B2 (en) 2010-10-29 2023-03-28 W. L. Gore & Associates, Inc. Non-fluoropolymer tie layer and fluoropolymer barrier layer
WO2020203239A1 (ja) 2019-03-29 2020-10-08 テルモ株式会社 プランジャーキット、シリンジキット及びプレフィルドシリンジ

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4159570A (en) * 1977-10-31 1979-07-03 Dentipressions Incorporated Disposable mixing syringe
US4613326A (en) * 1985-07-12 1986-09-23 Becton, Dickinson And Company Two-component medication syringe assembly
US5090962A (en) * 1989-04-28 1992-02-25 Flp Enterprises, Inc. Non-reusable syringe
US5665068A (en) * 1991-06-26 1997-09-09 Arte Corporation Dual chamber prefillable syringe
US6129712A (en) * 1998-11-05 2000-10-10 Daikyo Seiko, Ltd. Plunger for syringe
US20080195059A1 (en) * 2007-02-14 2008-08-14 Daikyo Seiko, Ltd. Syringe barrel and syringe
US20100145284A1 (en) * 2007-04-26 2010-06-10 Daikyo Seiko, Ltd. Needle-equipped syringe barrel needle-equipped syringe, and mold and method for molding same
US8002754B2 (en) * 2007-11-19 2011-08-23 Daikyo Seiko, Ltd. Plunger rod and syringe

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2914826B2 (ja) 1991-07-22 1999-07-05 株式会社大協精工 衛生品用容器
JPH09308689A (ja) * 1996-05-21 1997-12-02 Nihon Medi Physics Co Ltd 突起を有するプランジャーおよび注射器
JP4026871B2 (ja) 1996-05-24 2007-12-26 株式会社大協精工 ２室を結合した注射器
JP2892617B2 (ja) * 1996-06-18 1999-05-17 株式会社大協精工 注射器用滑栓
JP2003190285A (ja) * 2001-12-28 2003-07-08 Daikyo Seiko Ltd 注射器用ピストン
JP2006519070A (ja) * 2003-02-27 2006-08-24 バクスター・インターナショナル・インコーポレイテッド 注射器のためのピストンアセンブリ
JP2005282591A (ja) * 2004-03-26 2005-10-13 Nitto Seiko Co Ltd ボス部材とねじとの組合せ固定構造
JP2006181027A (ja) * 2004-12-27 2006-07-13 Daikyo Seiko Ltd 注射器用ピストン

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4159570A (en) * 1977-10-31 1979-07-03 Dentipressions Incorporated Disposable mixing syringe
US4613326A (en) * 1985-07-12 1986-09-23 Becton, Dickinson And Company Two-component medication syringe assembly
US5090962A (en) * 1989-04-28 1992-02-25 Flp Enterprises, Inc. Non-reusable syringe
US5665068A (en) * 1991-06-26 1997-09-09 Arte Corporation Dual chamber prefillable syringe
US6129712A (en) * 1998-11-05 2000-10-10 Daikyo Seiko, Ltd. Plunger for syringe
US20080195059A1 (en) * 2007-02-14 2008-08-14 Daikyo Seiko, Ltd. Syringe barrel and syringe
US20100145284A1 (en) * 2007-04-26 2010-06-10 Daikyo Seiko, Ltd. Needle-equipped syringe barrel needle-equipped syringe, and mold and method for molding same
US8002754B2 (en) * 2007-11-19 2011-08-23 Daikyo Seiko, Ltd. Plunger rod and syringe

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9572526B2 (en) 2009-05-13 2017-02-21 Sio2 Medical Products, Inc. Apparatus and method for transporting a vessel to and from a PECVD processing station
US9458536B2 (en) 2009-07-02 2016-10-04 Sio2 Medical Products, Inc. PECVD coating methods for capped syringes, cartridges and other articles
DE112010004275B4 (de) 2009-10-23 2019-08-14 Flextronics Ap, Llc Verfahren und Vorrichtung zum Formpressen von thermoplastischen Materialien mit hoher Geschwindigkeit und niedrigem Pressdruck
US9878101B2 (en) 2010-11-12 2018-01-30 Sio2 Medical Products, Inc. Cyclic olefin polymer vessels and vessel coating methods
US9272095B2 (en) 2011-04-01 2016-03-01 Sio2 Medical Products, Inc. Vessels, contact surfaces, and coating and inspection apparatus and methods
USD668760S1 (en) * 2011-06-17 2012-10-09 Daikyo Seiko, Ltd. Syringe barrel
US9664626B2 (en) 2012-11-01 2017-05-30 Sio2 Medical Products, Inc. Coating inspection method
US9903782B2 (en) 2012-11-16 2018-02-27 Sio2 Medical Products, Inc. Method and apparatus for detecting rapid barrier coating integrity characteristics
US9764093B2 (en) 2012-11-30 2017-09-19 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition
US10201660B2 (en) 2012-11-30 2019-02-12 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition on medical syringes, cartridges, and the like
US9662450B2 (en) 2013-03-01 2017-05-30 Sio2 Medical Products, Inc. Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus
US9937099B2 (en) 2013-03-11 2018-04-10 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging with low oxygen transmission rate
US9554968B2 (en) 2013-03-11 2017-01-31 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging
US9863042B2 (en) 2013-03-15 2018-01-09 Sio2 Medical Products, Inc. PECVD lubricity vessel coating, coating process and apparatus providing different power levels in two phases
US10369292B2 (en) 2016-01-15 2019-08-06 W. L. Gore & Associates, Inc. Syringe plunger assemblies

Also Published As

Publication number Publication date
JPWO2009011214A1 (ja) 2010-09-16
WO2009011214A1 (ja) 2009-01-22
EP2174681A4 (en) 2013-05-01
EP2174681A1 (en) 2010-04-14

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Legal Events

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AS Assignment

Owner name: DAIKYO SEIKO, LTD., JAPAN

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KAWAMURA, HIDEAKI;TOGASHI, HIROSHI;REEL/FRAME:023767/0319

Effective date: 20091204

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION