US20100003193A1 - Unit dosage of apadenoson - Google Patents

Unit dosage of apadenoson Download PDF

Info

Publication number
US20100003193A1
US20100003193A1 US12/496,949 US49694909A US2010003193A1 US 20100003193 A1 US20100003193 A1 US 20100003193A1 US 49694909 A US49694909 A US 49694909A US 2010003193 A1 US2010003193 A1 US 2010003193A1
Authority
US
United States
Prior art keywords
unit dose
apadenoson
amount
saline
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/496,949
Other languages
English (en)
Inventor
Robert Hendel
William B. Stilley
Shannon P. Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UVA Licensing and Ventures Group
Original Assignee
University of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Virginia Patent Foundation filed Critical University of Virginia Patent Foundation
Priority to US12/496,949 priority Critical patent/US20100003193A1/en
Assigned to VIRGINIA, UNIVERSITY OF reassignment VIRGINIA, UNIVERSITY OF ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: STILLEY, WILLIAM B., WILLIAMS, SHANNON P., HENDEL, ROBERT
Publication of US20100003193A1 publication Critical patent/US20100003193A1/en
Assigned to UNIVERSITY OF VIRGINIA PATENT FOUNDATION reassignment UNIVERSITY OF VIRGINIA PATENT FOUNDATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: UNIVERSITY OF VIRGINIA
Assigned to UNIVERSITY OF VIRGINIA PATENT FOUNDATION reassignment UNIVERSITY OF VIRGINIA PATENT FOUNDATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: UNIVERSITY OF VIRGINIA
Priority to US13/544,364 priority patent/US20130017153A1/en
Priority to US14/103,130 priority patent/US9415058B2/en
Priority to US15/181,235 priority patent/US9662406B2/en
Priority to US15/600,303 priority patent/US20170252463A1/en
Priority to US16/045,359 priority patent/US20190022253A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Definitions

  • the present invention relates to a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.
  • Apadenoson shown below, was first described as a pharmacologic stress agent
  • Dr. Hendel et al reported to the American Heart Association on the preliminary results of 127 patient SPECT Tc 99m sestamibi imaging studying comparing adenosine with Apadenoson using either 1 ⁇ g/kg or 2 ⁇ g/kg intravenous boluses of Apadenoson. The report concluded that Apadenoson was safe and well-tolerated and worthy of Phase III evaluation. In 2006, Dr.
  • Kern et al reported to the American Heart Association the results of a Phase II study of Apadenoson, one goal of which was to determine an appropriate dose for Phase III clinical trials.
  • Intravenous bolus dosages of 0.5, 1.0, 2.0, and 2.5 ⁇ g/kg were studied.
  • the average peak velocity for coronary blood flow was shown to increase with a corresponding increase in dosage from 0.5 to 2 ⁇ g/kg (see FIG. 1 ).
  • Apadenoson would need to be administered on a weight basis, not a unit dose basis.
  • the present invention provides a novel unit dose of Apadenoson suitable for parenteral administration.
  • the present invention also provides a novel method of diagnosing myocardial dysfunction using a unit dose of Apadenoson as a pharmacologic stress agent.
  • FIG. 1 shows the average peak flow wire velocity of one patient from a Phase II clinical trial study.
  • adenosine was administered by intracoronary injection, and coronary blood flow velocity was monitored with a flow wire.
  • the three injections of adenosine increased blood flow velocity consistent with the well characterized pharmacology of adenosine.
  • increasing bolus doses of Apadenoson at doses shown to be safe, achieved peak flow equivalent to adenosine.
  • FIG. 2 shows the average peak flow wire velocity of 33 patients from the study described in FIG. 1 .
  • CBFV coronary blood flow velocity
  • the present invention provides a novel unit dose of Apadenoson, comprising: (a) Apadenoson and (b) a pharmaceutically acceptable carrier, wherein the unit dose is suitable for parenteral administration.
  • the unit dose is suitable for intravenous administration.
  • the amount of Apadenoson present in the unit dose is selected from 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158,
  • the amount of Apadenoson present in the unit dose is in the range selected from 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, to 125 ⁇ g. Additional examples of the weight of Apadenoson present include (a) 115, 120, and 125 ⁇ g and (b) 120 ⁇ g.
  • the pharmaceutical carrier comprises: a cyclodextrin.
  • cyclodextrins include ⁇ -CD or derivatives thereof (e.g., ⁇ -hydroxypropyl-CD (HP- ⁇ -CD)), ⁇ -CD or derivatives thereof (e.g., ⁇ -hydroxypropyl-CD (HP- ⁇ -CD), methylated ⁇ -cyclodextrin, hydroxyethyl- ⁇ -cyclodextrin, and sulfobutylether ⁇ -CD), and ⁇ -CD or derivatives thereof (e.g., ⁇ -hydroxypropyl-CD (HP- ⁇ -CD)).
  • concentration of CD examples include being within the range selected from (a) about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10% w/v; (b) about 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, to 4% w/v; (c) about 1% w/v; and, (d) about 2% w/v of the final formulation.
  • CD e.g., hydroxypropyl- ⁇ -cyclodextrin
  • the pharmaceutical carrier comprises: buffered saline.
  • a useful buffer is a citrate buffer (e.g., sodium citrate).
  • Citric acid can be useful to adjust the pH of the unit dose.
  • the pharmaceutical carrier comprises: buffered saline, comprising: saline, sodium citrate, and citric acid.
  • buffered saline comprising: saline, sodium citrate, and citric acid.
  • citric acid may not be present in the final unit dose due to ionization.
  • the pH of the unit dose is selected from 4.6, 4.7, 4.8, 4.9, to 5.0.
  • Another example of the pH of the unit does is 4.8.
  • the volume of the unit dose is selected from 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, and 5 mL.
  • Another example of the volume is from 2, 3, 4, to 5 mL.
  • the unit dose comprises:
  • the unit dose comprises:
  • the unit dose comprises:
  • the unit dose comprises:
  • the unit dose of the present invention can be filled into any useful container for storage, transportation, and usage.
  • An example of a useful container is a syringe body.
  • the present invention provides a novel method of diagnosing myocardial perfusion abnormalities in a mammal, comprising:
  • the patient weighs at least 40 kg.
  • the administration is intravenous administration.
  • the technique is an imaging technique selected from: planar or single photon emission computed tomography (SPECT), gamma camera scintigraphy, positron emission tomography (PET), nuclear magnetic resonance (NMR) imaging, magnetic resonance imaging (MRI) imaging, perfusion contrast echocardiography, digital subtraction angiography (DSA), and ultrafast X-ray computed tomography (CINE CT).
  • SPECT planar or single photon emission computed tomography
  • PET gamma camera scintigraphy
  • PET positron emission tomography
  • NMR nuclear magnetic resonance
  • MRI magnetic resonance imaging
  • DSA digital subtraction angiography
  • CINE CT ultrafast X-ray computed tomography
  • the present invention provides a prefilled syringe, comprising: a syringe and a unit dose of Apadenoson, comprising: (a) Apadenoson and (b) a pharmaceutically acceptable carrier, wherein the unit dose is suitable for parenteral administration.
  • the syringe can be any known syringe useful for parenteral administration.
  • the syringe can comprise: a body and a plunger movably disposed within the body.
  • the body can be cylindrical with a first open end to receive the plunger and a second end opposite the first, with the second end modified with an opening sufficient for the unit dose to pass through.
  • the syringe can further comprise: a needle (e.g., an injection needle).
  • the needle can be detachably connected to or permanently fixed to the body.
  • a needle guard can also be present
  • the present invention provides a novel unit dose of Apadenoson for use in medical therapy.
  • the present invention provides a novel use of a unit dose of Apadenoson for the manufacture of a medicament for use in diagnosing myocardial perfusion abnormalities in a mammal.
  • the Apadenoson unit dose of the present invention can be administered as a pharmacological stress agent and used in conjunction with any one of several noninvasive diagnostic procedures to measure aspects of myocardial, coronary, and/or ventricular perfusion.
  • Aspects that can be measured include coronary artery stenoses, myocardial dysfunction (e.g., myocardial ischemia, coronary artery disease, ventricular dysfunction, and differences in blood flow through disease-free coronary vessels and/or stenotic coronary vessels), myocardial contractile dysfunction, the presence of regional wall motion abnormalities, the functional significance of stenotic coronary vessels, coronary artery disease, ischemic ventricular dysfunction, and vasodilatory capacity (reserve capacity) of coronary arteries in humans.
  • myocardial dysfunction e.g., myocardial ischemia, coronary artery disease, ventricular dysfunction, and differences in blood flow through disease-free coronary vessels and/or stenotic coronary vessels
  • myocardial contractile dysfunction e.
  • Radiopharmaceuticals are typically used in diagnostic method methods.
  • the radiopharmaceutical agent may comprise, for example, a radionuclide selected from the group consisting of thallium-201, technetium-99 m , nitrogen-13, rubidium-82, iodine-123 and oxygen-15.
  • Unit dose means the amount of a medication administered to a patient in a single dose.
  • a unit dose is typically independent of the weight of the patient or may be associated with a specified weight range (e.g., ⁇ 40kg).
  • Mammal and patient covers warm blooded mammals that are typically under medical care (e.g., humans and domesticated animals). Examples of mammals include (a) feline, canine, equine, and bovine and (b) human.
  • Parenteral includes intravenous, intramuscular, and subcutaneous routes.
  • Sterile injectable solutions are typically prepared by incorporating the active compound in the required amount in the appropriate solvent with various of the other ingredients enumerated above, as required, followed by filter sterilization (or some other form of sterilization).
  • filter sterilization or some other form of sterilization.
  • the methods of preparation include vacuum drying and the freeze drying techniques, which yield a powder of the active ingredient plus any additional desired ingredient present in the previously sterile-filtered solutions.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
US12/496,949 2008-07-03 2009-07-02 Unit dosage of apadenoson Abandoned US20100003193A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/496,949 US20100003193A1 (en) 2008-07-03 2009-07-02 Unit dosage of apadenoson
US13/544,364 US20130017153A1 (en) 2008-07-03 2012-07-09 Unit dosage of apadenoson
US14/103,130 US9415058B2 (en) 2008-07-03 2013-12-11 Unit dosage of Apadenoson
US15/181,235 US9662406B2 (en) 2008-07-03 2016-06-13 Unit dosage of apadenoson
US15/600,303 US20170252463A1 (en) 2008-07-03 2017-05-19 Unit dosage of apadenoson
US16/045,359 US20190022253A1 (en) 2008-07-03 2018-07-25 Unit dosage of apadenoson

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7816908P 2008-07-03 2008-07-03
US15593709P 2009-02-27 2009-02-27
US12/496,949 US20100003193A1 (en) 2008-07-03 2009-07-02 Unit dosage of apadenoson

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/544,364 Continuation US20130017153A1 (en) 2008-07-03 2012-07-09 Unit dosage of apadenoson

Publications (1)

Publication Number Publication Date
US20100003193A1 true US20100003193A1 (en) 2010-01-07

Family

ID=41152021

Family Applications (6)

Application Number Title Priority Date Filing Date
US12/496,949 Abandoned US20100003193A1 (en) 2008-07-03 2009-07-02 Unit dosage of apadenoson
US13/544,364 Abandoned US20130017153A1 (en) 2008-07-03 2012-07-09 Unit dosage of apadenoson
US14/103,130 Active US9415058B2 (en) 2008-07-03 2013-12-11 Unit dosage of Apadenoson
US15/181,235 Active US9662406B2 (en) 2008-07-03 2016-06-13 Unit dosage of apadenoson
US15/600,303 Abandoned US20170252463A1 (en) 2008-07-03 2017-05-19 Unit dosage of apadenoson
US16/045,359 Abandoned US20190022253A1 (en) 2008-07-03 2018-07-25 Unit dosage of apadenoson

Family Applications After (5)

Application Number Title Priority Date Filing Date
US13/544,364 Abandoned US20130017153A1 (en) 2008-07-03 2012-07-09 Unit dosage of apadenoson
US14/103,130 Active US9415058B2 (en) 2008-07-03 2013-12-11 Unit dosage of Apadenoson
US15/181,235 Active US9662406B2 (en) 2008-07-03 2016-06-13 Unit dosage of apadenoson
US15/600,303 Abandoned US20170252463A1 (en) 2008-07-03 2017-05-19 Unit dosage of apadenoson
US16/045,359 Abandoned US20190022253A1 (en) 2008-07-03 2018-07-25 Unit dosage of apadenoson

Country Status (24)

Country Link
US (6) US20100003193A1 (zh)
EP (1) EP2306971B1 (zh)
JP (2) JP2011526894A (zh)
KR (2) KR20110028531A (zh)
CN (1) CN102119023B (zh)
AU (1) AU2009266317B2 (zh)
BR (1) BRPI0913939A2 (zh)
CA (1) CA2729819C (zh)
CY (1) CY1116283T1 (zh)
DK (1) DK2306971T3 (zh)
EA (1) EA022348B1 (zh)
ES (1) ES2537069T3 (zh)
HK (1) HK1156250A1 (zh)
HR (1) HRP20150454T1 (zh)
IL (2) IL210428A (zh)
MX (1) MX2011000193A (zh)
MY (1) MY161655A (zh)
NZ (1) NZ590489A (zh)
PL (1) PL2306971T3 (zh)
PT (1) PT2306971E (zh)
SI (1) SI2306971T1 (zh)
SM (1) SMT201500123B (zh)
WO (1) WO2010002473A1 (zh)
ZA (1) ZA201100163B (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013114204A1 (en) 2012-02-03 2013-08-08 Adenobio N.V. A method of using adenosine and dipyridamole for pharmacologic stress testing, with specific compositions, unit dosage forms and kits
US9415058B2 (en) 2008-07-03 2016-08-16 University Of Virginia Patent Foundation Unit dosage of Apadenoson

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020881B (zh) * 2018-06-28 2020-04-28 新发药业有限公司 一种阿帕替尼的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646094A (en) * 1990-02-21 1997-07-08 Tallon; Jeffrey Lewis Rare earth substituted thallium-based superconductors
US6322771B1 (en) * 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US20020056473A1 (en) * 2000-11-16 2002-05-16 Mohan Chandra Making and connecting bus bars on solar cells
US20040002797A1 (en) * 2002-06-28 2004-01-01 Hopple Michael Robert Methods and systems for inspecting aircraft fuselage frames
US20040026030A1 (en) * 2000-10-23 2004-02-12 Hironori Hatono Composite structure body and method and apparatus for manufacturing thereof
US20090029185A1 (en) * 2007-07-27 2009-01-29 Cheng-Chang Lee Magnetic device and manufacturing method thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091171B2 (en) 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
IT1263831B (it) 1993-01-29 1996-09-04 Paolo Chiesi Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina
US7214665B2 (en) 2001-10-01 2007-05-08 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
US6232297B1 (en) * 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
EP1150991B1 (en) * 1999-02-01 2004-04-07 University of Virginia Patent Foundation Compositions for treating inflammatory response
US7427606B2 (en) 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
WO2003072597A1 (en) * 2002-02-27 2003-09-04 Ferring Bv Intermediates and methods for making heptapeptide oxytocin analogues
JP2006515829A (ja) * 2002-04-10 2006-06-08 ユニバーシティ オブ バージニア パテント ファウンデーション 炎症性疾病の処置のための、a2aアデノシン受容体アゴニストの使用
JP2007536241A (ja) * 2004-05-03 2007-12-13 ユニバーシティ オブ バージニア パテント ファウンデーション 糖尿病性腎症の処置のためのa2aアデノシンレセプターアゴニスト
EP1778712B1 (en) * 2004-08-02 2013-01-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
EP1729355B1 (en) 2005-06-03 2008-11-19 STMicroelectronics S.r.l. Self-aligned process for manufacturing phase change memory cells
US7767686B2 (en) 2006-03-03 2010-08-03 Covidien Ag Method of using adenosine receptor blockers during tissue ablation
DE102006022450A1 (de) 2006-05-13 2007-11-15 Lanxess Deutschland Gmbh Wässrige Rußdispersionen für Ink-Jet
US20090053168A1 (en) * 2007-07-17 2009-02-26 Richard Rickles Treatments of b-cell proliferative disorders
MY161655A (en) 2008-07-03 2017-04-28 Univ Virginia Patent Foundation Unit dosage of apadenoson

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646094A (en) * 1990-02-21 1997-07-08 Tallon; Jeffrey Lewis Rare earth substituted thallium-based superconductors
US6322771B1 (en) * 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US20040026030A1 (en) * 2000-10-23 2004-02-12 Hironori Hatono Composite structure body and method and apparatus for manufacturing thereof
US20020056473A1 (en) * 2000-11-16 2002-05-16 Mohan Chandra Making and connecting bus bars on solar cells
US20040002797A1 (en) * 2002-06-28 2004-01-01 Hopple Michael Robert Methods and systems for inspecting aircraft fuselage frames
US20090029185A1 (en) * 2007-07-27 2009-01-29 Cheng-Chang Lee Magnetic device and manufacturing method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Buffer," anon., available at (derived from Ruzin, Plant Microtechnique and Microscopy (1999)). *
Cerqueira, M., "Advances in Pharmacological Agents in Imaging: New A2A Receptor Agonists," Current Cardiology Reports 8: 119 - 122 (2006). *
Rajewski, R. and Stella, V., "Pharmaceutical Applications of Cyclodextrins. 2. In Vivo Drug Delivery," Journal of Pharmaceutical Sciences 85(11): 1142 - 1169 (1996) ("Rajewski (1997)"). *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9415058B2 (en) 2008-07-03 2016-08-16 University Of Virginia Patent Foundation Unit dosage of Apadenoson
US9662406B2 (en) 2008-07-03 2017-05-30 University Of Virginia Patent Foundation Unit dosage of apadenoson
WO2013114204A1 (en) 2012-02-03 2013-08-08 Adenobio N.V. A method of using adenosine and dipyridamole for pharmacologic stress testing, with specific compositions, unit dosage forms and kits

Also Published As

Publication number Publication date
US20140100185A1 (en) 2014-04-10
IL245577B (en) 2019-05-30
DK2306971T3 (en) 2015-05-11
ES2537069T3 (es) 2015-06-02
CA2729819A1 (en) 2010-01-07
KR20140021726A (ko) 2014-02-20
IL210428A (en) 2016-05-31
US20190022253A1 (en) 2019-01-24
AU2009266317A1 (en) 2010-01-07
MX2011000193A (es) 2011-03-24
PT2306971E (pt) 2015-06-18
MY161655A (en) 2017-04-28
CY1116283T1 (el) 2017-02-08
EA201100132A1 (ru) 2011-08-30
EP2306971B1 (en) 2015-02-25
US9662406B2 (en) 2017-05-30
IL245577A0 (en) 2016-06-30
CN102119023A (zh) 2011-07-06
CN102119023B (zh) 2014-04-09
US20130017153A1 (en) 2013-01-17
EP2306971A1 (en) 2011-04-13
CA2729819C (en) 2014-08-26
NZ590489A (en) 2013-01-25
HRP20150454T1 (hr) 2015-06-19
WO2010002473A1 (en) 2010-01-07
ZA201100163B (en) 2011-09-28
SMT201500123B (it) 2015-09-07
US20170252463A1 (en) 2017-09-07
SI2306971T1 (sl) 2015-07-31
IL210428A0 (en) 2011-03-31
US20170007722A1 (en) 2017-01-12
JP2013237702A (ja) 2013-11-28
HK1156250A1 (zh) 2012-06-08
KR20110028531A (ko) 2011-03-18
PL2306971T3 (pl) 2015-07-31
AU2009266317B2 (en) 2013-12-05
BRPI0913939A2 (pt) 2016-04-26
JP2011526894A (ja) 2011-10-20
EA022348B1 (ru) 2015-12-30
US9415058B2 (en) 2016-08-16

Similar Documents

Publication Publication Date Title
Criscione et al. Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging
Yu et al. BMS-747 158-02: a novel PET myocardial perfusion imaging agent
US20190022253A1 (en) Unit dosage of apadenoson
GOULD et al. Measurement of Regional: Myocardial Blood Flow in Dogs by Ultrafast CT
CN101951835B (zh) 纳米级对比剂和使用方法
US7534418B2 (en) Imaging agents
Koole et al. Preclinical safety evaluation and human dosimetry of [18 F] MK-6240, a Novel PET tracer for imaging neurofibrillary tangles
CN111870707B (zh) 一种锆[89Zr]炭微球混悬液及其制备方法和用途
Ji et al. Necrosis targeted combinational theragnostic approach to treat cancer
Landau et al. 6-Fluoro-6-deoxy-D-glucose as a tracer of glucose transport
EP2049007B1 (en) Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects
JP4863345B2 (ja) 心筋用放射性画像診断剤又は放射性治療薬
WO2008060466A2 (en) Individualized dosage determination for local administration of therapeutic particles
Dobrucki et al. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury
Ponto et al. Pharmacoimaging of blood-brain barrier permeable (FDG) and impermeable (FLT) substrates after intranasal (IN) administration
Kawano et al. Phase I clinical study of NMB58, a novel positron emission tomography (PET)-myocardial perfusion imaging tracer, conducted to evaluate its safety and pharmacokinetics in Japanese healthy adult males
UA108063C2 (xx) Дозована лікарська форма ападенозону
Habach Characterization of Myocardial Metabolism using a novel Hybrid PET/MRI Protocol combining fasting and glucose loading
Yamagishi et al. A reverse flow-metabolism mismatch pattern-A new marker of viable myocardium with greater contractility during dobutamine stress than myocardium with a flow-metabolism mismatch pattern
MATRIX EVALUATING THE CORRELATION BETWEEN TUMOR 2-DEOXY-2-[18F] FLUORO-D-GLUCOSE UPTAKE AND BLOOD FLOW IN AN EXPERIMENTAL LIVER TUMOR MODEL USING HYBRID POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY
CN115970012A (zh) 正电子心肌脂肪酸代谢显像剂与正电子18f-fdg心肌葡萄糖显像剂用于pet联合显像的用途
Raki et al. In vivo biodistribution studies and cell tracking in stroke using SPECT imaging
Czernin et al. Atlas of Cardiac Positron Emission Tomography
WO2003082347A1 (fr) Substance permettant de diagnostiquer des maladies associees a un trouble de la circulation du liquide cephalorachidien

Legal Events

Date Code Title Description
AS Assignment

Owner name: VIRGINIA, UNIVERSITY OF, VIRGINIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HENDEL, ROBERT;STILLEY, WILLIAM B.;WILLIAMS, SHANNON P.;REEL/FRAME:023723/0906;SIGNING DATES FROM 20091020 TO 20091202

AS Assignment

Owner name: UNIVERSITY OF VIRGINIA PATENT FOUNDATION,VIRGINIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:UNIVERSITY OF VIRGINIA;REEL/FRAME:024018/0621

Effective date: 20100302

Owner name: UNIVERSITY OF VIRGINIA PATENT FOUNDATION,VIRGINIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:UNIVERSITY OF VIRGINIA;REEL/FRAME:024019/0493

Effective date: 20100302

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION