US20090226502A1 - Balloon catheter devices with solvent-swellable polymer - Google Patents

Balloon catheter devices with solvent-swellable polymer Download PDF

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Publication number
US20090226502A1
US20090226502A1 US12/399,532 US39953209A US2009226502A1 US 20090226502 A1 US20090226502 A1 US 20090226502A1 US 39953209 A US39953209 A US 39953209A US 2009226502 A1 US2009226502 A1 US 2009226502A1
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United States
Prior art keywords
polymer
balloon
solvent
styrene
block copolymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/399,532
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English (en)
Inventor
John Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Boston Scientific Scimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Scimed Inc filed Critical Boston Scientific Scimed Inc
Priority to US12/399,532 priority Critical patent/US20090226502A1/en
Assigned to BOSTON SCIENTIFIC SCIMED, INC. reassignment BOSTON SCIENTIFIC SCIMED, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CHEN, JOHN
Publication of US20090226502A1 publication Critical patent/US20090226502A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1027—Making of balloon catheters
    • A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1027—Making of balloon catheters
    • A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
    • A61M2025/1031—Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2009/00—Layered products
    • B29L2009/005—Layered products coated

Definitions

  • the present invention relates to medical devices, more particularly, to catheter devices.
  • Balloon catheters having drug coatings may be used to treat diseased portions of blood vessels.
  • the balloon is inserted through a peripheral blood vessel and then guided via a catheter through the vascular system to the target intravascular site.
  • the flow of blood may wash away some of the drug coating.
  • the control of the timing, location and/or duration of the release of the drug can be an issue. Therefore, there is a need for improved catheter-based devices for drug delivery to an intravascular site.
  • the present invention provides a method for making a medical device, comprising: providing a balloon, wherein a wall of the balloon or a coating over the balloon comprises a polymer, wherein the polymer is swellable in an organic solvent; exposing said polymer to a mixture of said solvent and a therapeutic agent; and removing the solvent.
  • FIGS. 1A and 1B show a catheter device according to an embodiment of the present invention.
  • FIG. 1A shows the catheter device with the balloon in a deflated state.
  • FIG. 1B shows the catheter device with the balloon in an inflated state.
  • FIGS. 2A-2C schematically illustrate a polymer matrix in a balloon wall or a balloon coating according to an embodiment of the present invention.
  • FIG. 2A shows the polymer matrix prior to solvent exposure.
  • FIG. 2B shows the polymer matrix in an expanded condition after exposure to a mixture of a solvent and a therapeutic agent.
  • FIG. 2C shows the polymer matrix in a contracted condition after the removal of the solvent.
  • Catheter devices of the present invention use an expandable balloon for delivering a therapeutic agent to a target site in the body.
  • the balloon is designed to be insertable in the body via a catheter.
  • the therapeutic agent can be associated with the balloon in any of various ways, as further described below. Any of various mechanisms conventionally used for the delivery, actuation, or expansion (e.g., by inflation) of balloon catheter devices may be used in the present invention.
  • the balloon catheter may be designed similar to those that have been known in the art, including but not limited to angioplasty catheters, stent delivery catheters, inflation catheters and/or perfusion catheters.
  • the catheter devices of the present invention may be used in conjunction with other drug delivery devices, such as stents.
  • a balloon catheter 20 comprises a catheter body 22 having a balloon 24 mounted thereon.
  • the balloon In FIG. 1A , the balloon is in a deflated state; in FIG. 1B , the balloon is in an inflated state.
  • the body of the balloon can be single-layered or multiple-layered.
  • a balloon comprises a solvent-swellable polymer.
  • the solvent-swellable polymer may have a therapeutic agent incorporated therein and may be used to form a wall of the balloon or to form a coating disposed over the balloon.
  • the polymer is swellable upon exposure to an organic solvent.
  • the organic solvent can be polar or non-polar.
  • the organic solvent has a low boiling point.
  • the organic solvent has a boiling point of about 90° C. or less, about 80° C. or less, or about 70° C. or less. Solvents with low boiling points can be removed relatively easier than those with high boiling points.
  • Non-limiting examples of organic solvents include dichloromethane, chloroform, carbon tetrachloride, ethyl acetate, tetrahydrofuran, acetonitrile, hexane, and cyclohexane.
  • the solvent-swellable polymer is a semi-crystalline polymer.
  • the semi-crystalline polymer can form a polymer matrix having crystalline portions and amorphous portions.
  • the solvent and the therapeutic agent diffuses into and swells preferentially the amorphous regions of the polymer matrix.
  • the crystalline portions of the polymer matrix are more resistant to swelling, and therefore form a stable structure that maintains the physical structure of the polymer-containing balloon wall or coating.
  • the solvent is removed, the polymer matrix contracts to its original conformation, entrapping the therapeutic agent within the polymer matrix.
  • a catheter device comprises a balloon comprising a solvent-swellable, semi-crystalline polymer.
  • FIG. 2A shows a polymer matrix 70 on the wall of the balloon prior to solvent exposure.
  • Polymer matrix 70 has crystalline regions 72 , which are represented schematically by the lines, and amorphous regions 74 , which are represented schematically by the spaces.
  • FIG. 2B upon exposure to a mixture of a solvent and a therapeutic agent, amorphous regions 74 absorb the solvent and therapeutic agent 76 , causing polymer matrix 70 to swell.
  • FIG. 2C upon removal of the solvent, polymer matrix 70 contracts to its original conformation such that therapeutic agent 76 is retained within polymer matrix 70 .
  • the solvent-swellable polymer is a partially cross-linked polymer.
  • the cross-linking density is low to allow at least a portion of the polymer to swell in an organic solvent.
  • the cross-linking can be done using any known methods.
  • the cross-linking may be induced by UV irradiation or electron beam irradiation.
  • the cross-linked portions of the polymer serve as the stable structure, while the non-crosslinked portions of the polymer swell upon exposure to an organic solvent and entrap the therapeutic agent previously mixed with the solvent after the solvent is removed.
  • the solvent-swellable polymer is grafted onto the surface of the balloon through chemical bonding.
  • the balloon wall base itself serves as the stable structure, while the polymer swells upon exposure to an organic solvent and entraps the therapeutic agent previously mixed with the solvent after the solvent is removed.
  • Non-limiting examples of solvent-swellable polymers include block copolymers of styrene-ethylene/butylene-styrene (“SEBS”), block copolymers of styrene-ethylene/propylene-styrene (“SEPS”), block copolymers of styrene-butadiene-styrene (“SBS”), block copolymers of styrene-isoprene-styrene (“SIS”), polyolefins such as polyethylene and polypropylene, polyurethane, polyoxymethylene-acetyl copolymers, polyamide block copolymers, and copolymers of acrylates and methacrylates.
  • SEBS block copolymers of styrene-ethylene/butylene-styrene
  • SEPS styrene-ethylene/propylene-styrene
  • SBS block copolymers of styrene-buta
  • the SEBS, SEPS, SBS, and SIS copolymers can be commercially-available copolymers, such as those sold under the trade names KRATON G and KRATON D.
  • the solvent-swellable polymer has unsaturated bonds to allow for cross-linking or grafting.
  • the solvent may be removed by any known method, for example, evaporation or vacuum drying.
  • the solvent is removed without heating.
  • the solvent is removed by evaporation.
  • the balloon comprising a therapeutic agent-containing polymer is inserted into the body and delivered to the target site.
  • the balloon is then inflated, causing the polymer (in the case of a semi-crystalline polymer being used, polymer matrix 70 ) in the balloon wall to undergo expansion by mechanical force.
  • the therapeutic agent e.g. therapeutic agent 76
  • the therapeutic agent is released from the wall of the balloon. Because the therapeutic agent is preferably loaded through diffusion, it tends to locate near the surface of the wall or coating and can be easily released after the balloon catheter device is delivered to the target site.
  • Medical devices of the present invention may also include a vascular stent mounted on the balloon.
  • the vascular stent may be any of those known in the art, including those with or without coatings that contain a therapeutic agent.
  • the stent may also be biostable, bioerodable, or biodegradable.
  • the balloons of the present invention may also be coated with a low-molecular weight carbohydrate, such as mannitol.
  • the carbohydrate may be a separate coating or be blended with the therapeutic agent.
  • the balloons of the present invention may also be coated with a radiocontrast agent (ionic or non-ionic), such as iopromide.
  • the contrast agent may be a separate coating or be blended with the therapeutic agent.
  • the therapeutic agent used in the present invention may be any pharmaceutically acceptable agent (such as a drug), a biomolecule, a small molecule, or cells.
  • Example drugs include anti-proliferative agents or anti-restenosis agents such as paclitaxel, sirolimus (rapamycin), tacrolimus, everolimus, and zotarolimus.
  • Other example drugs include those that are anti-spasmodic agents and vasodilators.
  • Example biomolecules include peptides, polypeptides and proteins; antibodies; oligonucleotides; nucleic acids such as double or single stranded DNA (including naked and cDNA), RNA, antisense nucleic acids such as antisense DNA and RNA, small interfering RNA (siRNA), and ribozymes; genes; carbohydrates; angiogenic factors including growth factors; cell cycle inhibitors; and anti-restenosis agents.
  • Example small molecules include hormones, nucleotides, amino acids, sugars, and lipids and compounds have a molecular weight of less than 100 kD.
  • Example cells include stem cells, progenitor cells, endothelial cells, adult cardiomyocytes, and smooth muscle cells.
  • a double-layered balloon is manufactured.
  • the inner layer is made of high density polyethylene and the outer layer is made of SEBS (KRATON G, Kraton Polymers, Houston, Tex.).
  • SEBS KRATON G, Kraton Polymers, Houston, Tex.
  • the SEBS in the outer layer is crosslinked by electron beam irradiation.
  • the balloon is then immersed in a mixture of cyclohexane and paclitaxel for drug loading. After the balloon is taken out, the cyclohexane is removed by evaporation.
  • the balloon is then assembled onto a balloon catheter device.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US12/399,532 2008-03-06 2009-03-06 Balloon catheter devices with solvent-swellable polymer Abandoned US20090226502A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/399,532 US20090226502A1 (en) 2008-03-06 2009-03-06 Balloon catheter devices with solvent-swellable polymer

Applications Claiming Priority (2)

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US3432808P 2008-03-06 2008-03-06
US12/399,532 US20090226502A1 (en) 2008-03-06 2009-03-06 Balloon catheter devices with solvent-swellable polymer

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Family Applications (5)

Application Number Title Priority Date Filing Date
US12/399,532 Abandoned US20090226502A1 (en) 2008-03-06 2009-03-06 Balloon catheter devices with solvent-swellable polymer
US12/399,386 Abandoned US20090227948A1 (en) 2008-03-06 2009-03-06 Balloon catheter devices with sheath covering
US12/399,548 Expired - Fee Related US8114049B2 (en) 2008-03-06 2009-03-06 Balloon catheter devices with folded balloons
US13/179,054 Abandoned US20110270226A1 (en) 2008-03-06 2011-07-08 Balloon catheter devices with sheath covering
US13/289,490 Abandoned US20120053517A1 (en) 2008-03-06 2011-11-04 Balloon catheter devices with sheath covering

Family Applications After (4)

Application Number Title Priority Date Filing Date
US12/399,386 Abandoned US20090227948A1 (en) 2008-03-06 2009-03-06 Balloon catheter devices with sheath covering
US12/399,548 Expired - Fee Related US8114049B2 (en) 2008-03-06 2009-03-06 Balloon catheter devices with folded balloons
US13/179,054 Abandoned US20110270226A1 (en) 2008-03-06 2011-07-08 Balloon catheter devices with sheath covering
US13/289,490 Abandoned US20120053517A1 (en) 2008-03-06 2011-11-04 Balloon catheter devices with sheath covering

Country Status (5)

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US (5) US20090226502A1 (de)
EP (4) EP2594311A3 (de)
JP (2) JP2011513004A (de)
CA (1) CA2716985A1 (de)
WO (3) WO2009111712A1 (de)

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WO2009111709A3 (en) 2010-07-08
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US20110270226A1 (en) 2011-11-03

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