US20090135886A1 - Transbody communication systems employing communication channels - Google Patents
Transbody communication systems employing communication channels Download PDFInfo
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- US20090135886A1 US20090135886A1 US12/324,798 US32479808A US2009135886A1 US 20090135886 A1 US20090135886 A1 US 20090135886A1 US 32479808 A US32479808 A US 32479808A US 2009135886 A1 US2009135886 A1 US 2009135886A1
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B13/00—Transmission systems characterised by the medium used for transmission, not provided for in groups H04B3/00 - H04B11/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6861—Capsules, e.g. for swallowing or implanting
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B13/00—Transmission systems characterised by the medium used for transmission, not provided for in groups H04B3/00 - H04B11/00
- H04B13/005—Transmission systems in which the medium consists of the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37252—Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
Definitions
- Transbody communications generally refers to transmission of a signal from an in vivo location to a receiver location, e.g., a second in vivo location, a receiver location extracorporeally associated with the body, etc.
- noisy transmission environments may distort and corrupt communication data.
- the noisy transmission environments include the body.
- communication devices may err in signal generation and measurement related to the communication data.
- various devices and combinations of devices may exact high power consumption, resulting in a relatively short life cycle for the devices inside the body. Such a short life cycle may result in replacement surgeries and other inconvenient, expensive, and/or high-risk procedures.
- the system includes an in vivo transmitter to transmit an encoded signal; a transbody functionality module to facilitate communication of the encoded signal; and a receiver to receive the encoded signal to at least facilitate accurate transbody communications and conserve power consumption.
- the system may further include at least one of a beacon functionality module, a frequency hopping functionality module, and a collision avoidance functionality module. Related methods and apparatus are also provided.
- FIG. 1 illustrates a communication environment, including a transbody communication system having a transbody functionality module.
- FIG. 2 illustrates the transbody functionality module of FIG. 1 in greater detail.
- FIG. 3A illustrates a beacon wakeup module providing a sniff period longer than a transmit signal repetition period.
- FIG. 3B illustrates a beacon wakeup module providing a short but frequent sniff period and a long transmit packet are provided.
- FIG. 4A illustrates a resonant, narrow band analog circuit.
- FIG. 4B illustrates classic power detection circuit.
- FIG. 5 illustrates beacon functionality having a long period of a continuous wave tone.
- FIG. 6 illustrates a beacon functionality wherein a beacon is associated with one frequency and a message is associated with another frequency.
- FIG. 7 illustrates a beacon functionality associated with a two-beacon scheme.
- FIG. 8 illustrates a beacon functionality associated with a beacon signal where frequency is a function of time.
- FIG. 9 further illustrates a beacon functionality associated with a beacon signal where frequency is a function of time.
- FIG. 10 illustrates a collision avoidance functionality having one collision avoidance technique.
- FIGS. 11A-11D illustrate a collision avoidance functionality having another collision avoidance approach.
- FIGS. 12A and 12B illustrate a collision avoidance functionality having a technique to detect a low amplitude signal in a noisy environment.
- Transbody communication systems employing communication channels.
- Various aspects facilitate accurate communications in noisy environments as well as provide enhanced power conservation features. More particularly, various aspects may be associated with transbody communication systems, e.g., an in vivo transmitter and a signal receiver (sometimes referred to herein as a “receiver”) associated with a body.
- the receiver may be configured to receive and decode a signal from the in vivo transmitter.
- Various aspects of the invention are characterized by employing a specific communication channel having transbody functionality, e.g., via a transbody functionality module. Related methods are also provided.
- the invention may have broad applicability to medical and non-medical fields.
- the medical fields include, for example, transbody communications systems associated with various medical and therapeutic devices, e.g., cardiac devices, ingestible devices, etc.
- the non-medical fields include, for example, body associated devices such as gaming devices incorporating physiologic sensing functionality, etc.
- FIG. 1 illustrates a communication environment 100 , including a transbody communication system 102 .
- the transbody communication system 102 comprises, for example, an in vivo transmitter 104 , a transbody functionality module 106 , and a receiver 108 .
- the in vivo transmitter 104 transmits a signal, e.g., an encoded signal, via the transbody communication module 104 to the receiver 108 , as hereinafter described in detail.
- an in vivo transmitter 102 includes any in vivo device capable of transmitting a signal, e.g., an encoded signal.
- the in vivo transmitter 102 may be associated with various devices, e.g., cardiac-related devices, ingestible devices, neural-stimulation related devices, medications, etc.
- the in vivo transmitter 102 may be wholly or partially integrated with such a device, medication, etc.
- Such a device is a pharma-informatics enabled pharmaceutical composition, described in PCT Application Serial No. US2006/016370.
- Another example is an ingestible event marker (IEM) and a personal receiver, described in U.S. Provisional Patent Application Ser. No. 60/949,223.
- Still another example is a smart parenteral device, described in PCT/US2007/15547.
- Yet another example is a smart implantable fluid transport device, described in U.S. Provisional Patent Application Ser. No. 60/989,078.
- Still further examples include implantable physiologic event recorders, described in U.S. Pat. Nos.
- the signal transmitted by the device generally includes any signal, data, identifier, representative thereof, etc.
- Signals include encoded signals, e.g., encode at origin and decoded at destination. Examples of signals include an identifier of a pharmaceutical, a parenteral delivery device, an ingestible event marker, etc., supra.
- the signal may be transmitted from the in vivo transmitter 104 via the transbody functionality module 106 to the receiver 108 .
- the transbody functionality module 106 generally uses protocol(s), communication channels, etc., capable of facilitating accurate receipt of signals, data, etc. and/or facilitating low power consumption.
- Such transbody functionality modules 106 include beacon functionality frequency hopping functionality and collision avoidance functionality.
- the transbody functionality module 106 may be implemented as software, e.g., digital signal processing software; hardware, e.g., a circuit; or combinations thereof.
- Communication media for transmission may vary.
- the body of a patient may be employed as a conduction medium for the signal.
- the signal is conducted between the in vivo transmitter and the receiver via body fluids, etc. in another aspect, the signal is transmitted via radio frequency (RF) transmission.
- RF radio frequency
- FIG. 2 illustrates the transbody functionality module 106 of FIG. 1 in greater detail.
- the transbody functionality modules includes a beacon functionality module 200 , a frequency hopping functionality module 202 , and a collision avoidance functionality module 204 .
- the beacon functionality module 200 may employ one or more of the following: a beacon wakeup module 200 A, a beacon signal module 200 B, a wave/frequency module 200 C, a multiple frequency module 200 D, and a modulated signal module 200 E.
- the beacon functionality module 200 may be associated with beacon communications, e.g., a beacon communication channel, a beacon protocol, etc.
- beacons are typically signals sent either as part of a message or to augment a message (sometimes referred to herein as “beacon signals”).
- the beacons may have well-defined characteristics, such as frequency. Beacons may be detected readily in noisy environments and may be used for a trigger to a sniff circuit, such as those described above.
- the beacon functionality module 200 may comprise the beacon wakeup module 200 A, having wakeup functionality.
- Wakeup functionality generally comprises the functionality to operate in high power modes only during specific times, e.g., short periods for specific purposes, e.g., to receive a signal, etc.
- An important consideration on a receiver portion of a system is that it be of low power. This feature may be advantageous in an implanted receiver, to provide for both small size and to preserve a long-functioning electrical supply from a battery.
- the beacon wakeup module 200 A may enable these advantages by having the receiver operate in a high power mode for very limited periods of time. Short duty cycles of this kind can provide optimal system size and energy draw features.
- the receiver may “wake up” periodically, and at low energy consumption, to perform a “sniff function” via, for example, a sniff circuit.
- the term “sniff function” generally refers to a short, low-power function to determine if a transmitter is present. If a transmitter signal is detected by the sniff function, the device may transition to a higher power communication decode mode. If a transmitter signal is not present, the receiver may return, e.g., immediately return, to sleep mode. In this manner, energy is conserved during relatively long periods when a transmitter signal is not present, while high-power capabilities remain available for efficient decode mode operations during the relatively few periods when a transmit signal is present.
- FIG. 3A illustrates the beacon wakeup module 200 A wherein a sniff period 300 is longer than a transmit signal repetition period 302 .
- the time function is provided on the x axis.
- the transmit signal repeats periodically, with a sniff function also running.
- the sniff period 300 is typically longer than the transmit signal repetition period 302 .
- the sniff function e.g., implemented as a sniff circuit, is guaranteed to have at least one transmission to occur each time the sniff circuit is active.
- FIG. 3B illustrates the beacon wakeup module 200 A wherein a short but frequent sniff period 306 and a long transmit packet 308 are provided.
- the sniff circuit will activate at some point during the transmit time. In this manner, the sniff circuit may detect the transmit signal and switch into a high power decode mode.
- An additional beacon wakeup aspect is to provide the “sniffing” function in a continuous mode.
- this aspect of the transbody beacon transmission channel may exploit the fact that the total energy consumption is the product of average power consumption and time.
- the system may minimize the total energy consumption by having very short periods of activity, in which case the periods of activity are averaged down to a small number.
- a low continuous sniff activity is provided.
- the configuration provides a sufficiently low power so that the transmission receiver runs continuously with a total energy consumption at an appropriate level for the parameters of a specific system.
- the system may be passive. Two examples of circuit implementations are provided.
- FIG. 4A illustrates a resonant, narrow band analog circuit 400 , including input antenna 402 , inductor 404 , and capacitors 406 .
- the resonant, narrow band analog circuit 400 may have a high impedance.
- An LC resonator may be provided that is tuned to the frequency of the transmitted signal. The voltage across the LC circuit may be measured, and run into a comparator. When the voltage measurement exceeds a certain value, a gate may be triggered. The circuitry goes then into a high power mode.
- FIG. 4B shows a classic power detect circuit 408 .
- the power detect circuit 408 may be of those known in the art, such as those used in an AM radio to give a light signal that indicates receipt of a radio signal.
- the power detect circuit 408 is an LC resonant circuit, i.e., a tank circuit. When a signal of the LC resonant frequency is present, the LC tank circuit ‘rings up’. Because the circuit has a high Q, its voltage increases dramatically. That voltage is rectified by the diode. When that voltage exceeds a threshold set by Vref, a comparator is triggered. The comparator informs the microprocessor that a signal/circuit is present and directs it to enter the high power mode.
- Each of the above-described circuits may be very low powered and may comprise only passive components, with the exception of the comparator.
- the comparator may also be of very low power.
- Each circuit may operate continuously.
- Each circuit may inform the microprocessor when a transmitter is present, e.g., a signal is transmitted, to go into the high power mode.
- a useful prerequisite may be a well defined frequency for the transmitter.
- a type of beacon signal associated with the present transbody communication channel is a continuous wave, single frequency tone.
- the continuous single frequency tone triggers either of the circuits in FIG. 4A or 4 B, when they are tuned to the correct frequency.
- the beacon signal module 200 B may provide for beacon signals to be detected digitally, as shown in FIG. 3A or 3 B. This may be accomplished by sampling the beacon signals with an A->D converter. The beacon signals are put in a digital processing system. Beacon signals are detected by a single frequency tone which has a very strong characteristic.
- FIG. 5 Examples of such systems are provided in FIG. 5 .
- FIG. 5 illustrates beacon functionality having a long period of a continuous wave tone, e.g., via the wave/frequency module 200 C.
- the beacon signal consists of a long period of the continuous wave tone.
- This continuous wave tone has both a modulated portion, which holds the information, and unmodulated portion. In this frequency domain, there is typically a period of well defined frequency. The modulation tends to smear the frequency spectrum.
- This portion of the wave tone serves as the beacon. It has a single tone in the frequency domain, and is easily recognizable in the spectrogram.
- Either of the methods shown previously can detect the single frequency tone. This frequency tone alerts the processing circuitry that a message is coming. It then it moves into decode mode so that the message can be understood. In FIG. 5 , this is shown as one packet.
- FIG. 6 illustrates beacon functionality wherein a beacon is associated with one frequency, e.g., a beacon channel, and a message is associated with another frequency, e.g., a message channel.
- a beacon is associated with one frequency, e.g., a beacon channel
- a message is associated with another frequency, e.g., a message channel.
- the solid line represents the beacon from Transmit Signal 1 .
- the dashed line represents the beacon from Transmit Signal 2 .
- the Transmit Signal 2 's beacon might overlap with that of Transmit Signal 1 , as depicted.
- Message Signal 1 and Message Signal 2 can be at different frequencies from their respective beacons.
- One advantage may be that the beacon from Transmit Signal 2 does not interfere with the message from Transmit Signal 1 at all, even though they are transmitted at the same time.
- the beacon from the second transmit signal would most likely obscure the message from the first transmit signal.
- the beacon channel is a well defined frequency band.
- a message is provided in the channel where the data are actually transmitted. Interference between different messages in the message channel can be handled through collision avoidance, described below. While FIG. 6 is shown with two transmitters, it will be apparent to one of ordinary skill in the art to modify the system so as to scale it to many more transmitters. The requirements of a particular system may, to some extent, dictate the particular architecture of that system.
- FIG. 7 illustrates beacon functionality associated with a two-beacon scheme, e.g., Beacon 1 and Beacon 2 .
- the beacon is a continuous wave signal, or a signal with a very simple modulation, it will be a simple matter to detect the carrier frequency of the beacon signal.
- the beacon is at frequency 2 f
- the message is at frequency f, as shown in FIG. 7 .
- the value of f can be determined from the beacon channel.
- the frequency is known exactly.
- This aspect may be used, inter alia, to address frequency uncertainty.
- This approach may provide a workable system for message channel modulations which do not have well defined carrier frequencies.
- message channel modulations are spread spectrum modulations.
- An attempt to determine the frequency of a spread spectrum modulation in and by itself, can be difficult because there is not a well defined peak in the frequency spectrum.
- having the beacon channel accompanying the message channel with a well-defined mathematical relationship allows the message channel frequency to be determined precisely from the beacon channel. The message channel can then be demodulated based on that information.
- the beacon could have a simple modulation on it.
- An example of such an aspect is using on-off keying (OOK), or simple frequency modulation.
- OOK on-off keying
- simple frequency modulation of particular utility is a frequency key shifting (FSK) two tone beacon signal created by two different divide ratios of the master silicon oscillator. This may provide both a unique spectral signature and the frequency ratio of the two tones are invariant to the frequency drift of the silicon oscillator, e.g., an IEM silicon oscillator.
- the frequency ratio metric may provide a high probability that the signal detected is sourced by the preferred source device, e.g., the IEM.
- This approach gives the beacon a distinctive signature that is uniquely identifiable from other interferers. In this manner, the system does not risk confusing the beacon with other jammers from the environment.
- One key characteristic of the frequency is that it stands out as distinctive, and still has a well-defined mathematical relationship in terms of carrier frequency.
- FIG. 8 illustrates beacon functionality associated with a beacon signal where frequency is a function of time.
- the carrier frequency is set by a silicon oscillator, and not by a crystal oscillator. This introduces a large uncertainty in characteristic frequency. Determination of that frequency may be a key challenge, both in terms of decoding the packet and detecting the beacon frequency.
- FIGS. 4A and 4B provide an example of this approach. If these circuits have high power (Q), the frequency uncertainty may cause the beacon to fall outside of the response function of the sniff circuits. Thus, as illustrated in FIGS. 8 and 9 another type of beacon may be employed.
- Frequency 700 is ramped over some range, providing a message.
- Two narrow band filters are provided. The signal is ramped from an f high to an f low .
- Two narrow band filters are tuned to f 1 and f 2 , e.g., via the multiple frequency module 200 D. Frequencies f 1 and f 2 fall between f high and f low .
- the output of the filter at f 1 shows no power, shows a blip in power as the beacon frequency is ramped through f 1 at time t 1 , and then shows no power.
- the output of the filter at f 2 would show no power, show a blip in power as the beacon frequency is ramped through f 2 at time t 2 , and then shows no power.
- an analog sniff circuit is employed which triggers on the time difference between t 1 and t 2 .
- This can be implemented digitally or in an analog approach. In this case, when the circuit is set on time t 1 , if time t 2 falls within some defined window t 0 , it indicates that a signal is present.
- the ramp is a very distinctive signature. Frequency f 1 firing will be detected, and (by example) 10 ms later, f 2 firing is detected. If those two events happen within the defined time interval to, plus or minus t′, it indicates that a signal is present. The wakeup circuit is then triggered. The resulting design provides a very low power analog circuit. An important application of the circuit is to determine the frequency as shown in FIG. 8 .
- the beacon may be modulated to assure that its signature will be distinctive, e.g., via the modulated signal module 200 E.
- One approach to this method is to have the beacon alternate between two frequencies. When this alternation is detected with the well-defined frequency difference and well-defined time period, the confidence level can be very high that a beacon had been detected, rather than some background signal. A similar result can be achieved with on-off keying, in a frequency modulation keying approach.
- any standard modulation technique can be applied to a beacon to give it a distinctive character.
- data may be imprinted on the beacon, to avoid it being confused with any other signal.
- the sniff circuit triggers only on the beacon.
- beacon approaches There are multiple beacon approaches available to avoid interference.
- transmitter 1 could have beacons at multiple frequencies, e.g., via multiple frequency module 200 D, to avoid effects from interference.
- the aspect is simply to have beacons at different frequencies to avoid contention between the beacons.
- a frequency ratio of a beacon and data channel is invariant to frequency error in the ingestible event marker system to provide additional assurance of detection of the encoded signal.
- the frequency hopping functionality module 202 may be associated with the specific communications channel(s), frequency hopping protocol, etc. As such, various aspects may utilize one or more frequency hopping protocols. For example, the receiver may search the designated range of frequencies in which the transmission could fall. When a single proper decode is achieved, the in vivo transmitter has accomplished its mission of communicating its digital information payload to the receiver.
- the transmitted frequency uncertainty provided by random frequency hopping, e.g., via a random module 202 A, may create multiple benefits.
- One such benefit may be easy implementation on a small die.
- the in vivo transmitter carrier frequency oscillator can be an inaccurate free running oscillator that is easily implemented on a small portion of a 1 mm die. Accuracies on the order of +/ ⁇ 20 are easily tolerated. This is because the receiver employs frequency searching algorithms.
- Another such benefit may be extended battery life.
- the probability of the transmitter transmitting on a clear channel that can be received by the frequency agile receiver may be significantly enhanced due to random frequency hopping.
- Still another benefit may be minimized collision events in high volume environments.
- the useful frequency spectrum for use in volume conduction applications ranges from about 3 kHz to 150 kHz.
- the in vivo transmitter supra, having a received signal level in the range of 1 to 100 ⁇ V may compete with narrow band interfering signals on the order of hundreds to thousands of ⁇ V in the same frequency spectrum.
- a frequency hopping channel or protocol may be employed in which the in vivo transmitter randomly frequency hops a narrow band transmitted signal, e.g., a modulated signal such as a binary phase shift keying (BPSK) signal or FSK signal, output on each transmission.
- BPSK binary phase shift keying
- the collision avoidance functionality module may be associated with the specific communications channel(s), collision avoidance protocols, etc.
- various aspects may utilize various collision avoidance protocol techniques associated with the specific communications channel(s). Collision avoidance techniques may be particularly useful, for example, in environments where two or more in vivo transmitters are present, e.g., where an individual ingests multiple IEMs. In such an environment, if the various in vivo transmitters send their signals continuously, the transmission of one may obscure the transmission from all the other in vivo transmitters. As a result, failure to detect signals may increase significantly.
- Various aspects may include various collision avoidance approaches, alone or in various combinations.
- One such approach employs multiple transmit frequencies. By using frequency-selective filtering, the transmitter broadcasting at f 1 can be distinguished from the transmitter broadcasting at f 2 , even if they are transmitting simultaneously.
- An alternative to this approach is illustrated in FIG. 9 .
- FIG. 10 illustrates a first collision avoidance technique, e.g., via a transmitter module 204 A, wherein Transmitter 1 is broadcasting on f 1 .
- Transmitter 2 is broadcasting on f 2 .
- a receiver and two band pass filters are provided, e.g., via multiple band pass filter module 204 E.
- Band pass filter 1 is sensitive to f 1
- band pass filter 2 is sensitive to f 2 .
- FIGS. 11A-11D illustrate another collision avoidance approach.
- the specific communications channel(s) may employ duty cycle modulation, e.g., via a duty cycle modulation module 204 B, wherein a transmitter need not transmit all the time. If two transmitters, e.g., xmtr 1 and xmtr 2 , are not transmitting simultaneously, they will not interfere with each other. For example, If two transmitters are used which have low duty cycles, such as broadcasting 10% of the time and off 90% of the time, then probabilistically there is only a 20% chance that the signals will overlap with each other. In this manner, collisions may be avoided.
- transmitter 1 e.g., xmtr 1
- transmitter 2 e.g., xmtr 2
- that probability can be controlled by changing the duty cycle and the frequency spread.
- the overlap can be controlled, however, by dithering the duty cycle and the frequency spread, e.g., via dither module 204 F and spread spectrum module 204 D, respectively. In this manner, otherwise occurring collisions may be avoided.
- dashed transmitter xmtr 2 has a slightly shorter period than the solid transmitter xmtr 1 . Even though the transmitters begin broadcasting at the same time, after some number of transmissions, the transmitters come out of alignment with each other. As a result, they are now distinct from one another and otherwise occurring collisions may be avoided.
- a similar effect can be obtained by having a spread of oscillator frequencies.
- the silicon oscillators used for these transmitters have a spread of a few percent in frequency.
- a 1% difference in frequency means that after a 100 transmissions, two oscillators 1008 , 1010 that began in phase with each other are no longer in phase with each other.
- Various aspects may be based on frequency distribution or the frequencies can also be programmed to be explicitly different, e.g., to have some range of periods. Noise dithering a voltage controlled oscillator frequency can also create this frequency spread.
- the retry period is randomized.
- xmtr 1 broadcasts and then waits some random period of time before broadcasting again.
- the xmtr 1 then waits another random period of time before broadcasting again, and so forth.
- Xmtr 2 begins broadcasting at the same time. However, in this case it waits a random time before the next transmission, and waits another random time before the next transmission and so forth. In this way, the probability that two transmitters broadcast simultaneously can be controlled by affecting the standard deviation of the retry periods.
- This approach can be based on a pseudo-random sequence that is preprogrammed into the chip. It can also be based on a real physical random number generator (thermal noise), or on the serial number on the chip. Since every transmitter has a unique serial number, some of the lower bits of the serial number can be used to program this randomization time, either directly or by using a linear shift register.
- transbody transmission channel uses spread spectrum transmission to modulate the transmit message.
- This approach can be direct spread spectrum or frequency hopping spread spectrum.
- CDMA code division multiple access
- This aspect can also be based on any of the well known codes in spread spectrum, such as Gold Codes or Kasami codes.
- a code is selected such that there are sufficiently many that the probability of two transmitters having the same code broadcasting at the same time is sufficiently small.
- This approach ties into the idea of using a beacon to find the carrier frequency because spread spectrum transmissions in general do not have a well defined carrier frequency. That information is determined, such as from the beacon.
- duty cycle works very well for two or three transmitters operating simultaneously.
- the duty cycle method breaks down when there are more than five transmitters providing data in an overlapping time frame.
- the most straightforward method to bolster the duty cycle is to add retransmit randomization, e.g., via retransmit randomization module 204 C.
- retransmit randomization module 204 C By adding a few bits of retransmit randomization, the effect is immediately rendered much less pronounced. In this aspect, the system can easily distinguish five to ten simultaneous transmissions.
- Plots on long duty cycle show with three simultaneous transmitters there is about a 1% chance of a transmitter not being detected because of a collision. This is during a one minute transmit interval.
- One important feature of some transmitters systems is that the transmitters have a finite lifetime. In systems where transmitters have very long lifetimes, these concerns may be absent.
- the transmitter can listen for a quiet channel, for example, waiting until it hears nothing transmitting and then transmit.
- the spread spectrum approach is quantifiable, depending on how many distinct codes are used.
- the Kasami set of codes are used there are 32,000 distinct codes.
- the probability of having two transmitters transmit on the same code is 1/(32,000) 2 . That probability goes up geometrically with the number of transmitters. Even doing nothing to select transmitters that have distinct codes, and relying on the randomization of code selection, it supports tens, if not hundreds, of transmitters.
- receivers of the system are configured to selectively receive a signal in a quiet part of a given spectrum.
- FIG. 12A shows an aspect addressing the problem of detecting a low amplitude signal in a noisy environment.
- One approach to that problem is to find a quiet place in the noise spectrum.
- the detector of the receiver is programmed to that frequency band.
- the transmitter periodically broadcasts in that frequency band.
- FIGS. 12A and 12B illustrate a technique to detect a low amplitude signal in a noisy environment.
- power is a function of frequency.
- the broadcast is provided in the quiet region because the least amount of interference is in that region.
- the transmission occurs at multiple different frequencies, e.g., a ramping scheme.
- other schemes may be used such as frequency hopping or random scheme.
- the chosen scheme will densely covers the frequency band of interest.
- the transmitter will eventually jump into the quiet band and eventually transmit in the quiet band.
- SNR signal to noise ratio
- receivers as described in any of the following applications may be configured to receive only a quiet channel: PCT application serial no. US2007/024225 titled “Active Signal Processing Personal Health Signal Receivers,” and filed on Nov. 19, 2007; WO 2006/116718; 60/866,581; 60/945,251; 60/956,694, 60/887,780 and 2006/116718; the disclosures of which applications are herein incorporated by reference.
- transmissions are broken into two channels.
- the first channel is used to broadcast the data.
- a one to two percent duty cycle is performed. Immunity to collisions is enhanced by randomizing the re-broadcast rate.
- the second channel is used to broadcast a wakeup beacon.
- a one to two percent duty cycle is performed.
- the packet rate is in the 10 mSec range.
- the beacon transmissions are short, in the range of 100 to 200 uSec, when collisions are not of concern.
- the beacon and data channel carriers are generated from the same oscillator, so from the beacon the data carrier can be calculated.
- the receiver will turn on every 10 to 30 seconds for a 10 mSec duration. If a beacon is observed, the receiver will stay on to perform a full demodulation and decode. Otherwise, the receiver will return to sleep.
- the above system is modified to include a frequency dither to the packet interval dither.
- the above system is modified to include a longer duration transmission of 16 carrier cycles at 25 kHz (640 uS) with a 1 to 2 percent duty cycle. This complies with narrow band filter compatibility.
- the above system is modified to so that the modulation as BPSK on OOK on the lower channel.
- the above system is modified so that the modulation as OOK burst on the higher beacon channel.
- the above system is modified so that the use of simple multidimensional parity check codes for FEC (forward error correction).
- the signal receiver generally includes any device or component capable of receiving the signal, e.g., conductively receiving a signal via one or more specific communication channels.
- the receiver has a small size.
- the receiver may occupy a volume of space of about five cm 3 or fewer, such as about three cm 3 or fewer, including about one cm 3 or less.
- the receiver has a chip size approximately ranging from ten mm 2 to two cm 2 .
- the receivers of interest may include both external and implantable receivers.
- the receiver may be ex vivo, i.e., present outside of the body during use.
- External receiver may be configured in any convenient manner.
- the externals receivers may be configured to be associated with a desirable skin location.
- the external receivers may be configured to contact a topical skin location of a subject.
- Configurations of interest include, but are not limited to: patches, wrist bands, belts, etc.
- a watch or belt worn externally and equipped with suitable receiving electrodes can be used as receivers in accordance with one aspect of the present invention.
- the receivers may provide a further communication path via which collected data can be extracted by a patient or health care practitioner.
- an implanted collector may include conventional RF circuitry operating, e.g., in the 405-MHz medical device band, with which a practitioner can communicate.
- the practitioner may communicate, for example, via a data retrieval device, such as a wand, etc.
- the receiver may have output devices for providing data, e.g., audio and/or visual feedback. Examples include audible alarms, LEDs, display screens, or the like.
- the external component may also include an interface port via which the component can be connected to a computer for reading out data stored therein.
- the device may be positioned by a harness that is worn outside the body and has one or more electrodes that attach to the skin at different locations.
- the receiver may be configured to be in contact with or associated with a patient only temporarily, i.e., transiently.
- the receiver may be associated/attached/in contact while the pill, ingestible event marker, etc., is actually being ingested.
- the receiver may be configured as an external device having two finger electrodes or handgrips.
- the patient touches the electrodes or grabs the handgrips to complete a conductive circuit with the receiver.
- the signal emitted by the identifier of the pill is picked up by the receiver.
- the external receiver may include miniaturized electronics which are integrated with the electrodes to form a bandage-style patch with electrodes that, when applied, contact the skin.
- the bandage-style may be removably attachable, e.g., via an adhesive layer or other construction.
- a battery and electronics may also be included.
- the bandage-style patch may be configured to be positioned on a desirable target skin site of the subject, e.g., on the chest, back, side of the torso, etc.
- the bandage circuitry may be configured to receive signals from devices inside of the subject, e.g., from an identifier of a pharma-informatics enabled pharmaceutical composition, and then relay this information to an external processing device, e.g., a PDA, smartphone, mobile phone, handheld device, computer, etc., as described in greater detail elsewhere.
- an external processing device e.g., a PDA, smartphone, mobile phone, handheld device, computer, etc.
- Bandage-style devices that may be readily adapted for use in the present systems include, but are not limited to, those described in U.S. Pat. No. 6,315,719 and the like, the disclosures of which are herein incorporated by reference.
- the receiver may be an implantable, i.e., designed and/or configured for implantation into a subject. Implantation may be on a temporary basis or a permanent basis. In these aspects, the receiver is in vivo during use.
- implantable receivers may maintain functionality when present in a physiological environment, including a high salt, high humidity environment found inside of a body, for various periods of time. Periods of time, for example, include a few minutes to eighty years. More specific time periods include, for example, one or more hours, one or more days, one or more weeks, one or more months, and one or more years.
- the receiver may have any convenient shape, including but not limited to: capsule-shaped, disc-shaped, etc.
- Various receivers may have relatively small sizes. These small sizes may be achieved, for example, by incorporation of a rechargeable battery.
- the rechargeable battery has a life span of about two weeks.
- the rechargeable battery automatically charges from various sources, e.g., coils in the patient's bed.
- the receiver may be configured to be placed in a number of different locations. Examples of locations include the abdomen, the small of the back, the shoulder, e.g., where implantable pulse generators are placed, etc.
- the receiver is a standalone device, i.e., not physically connected to any other type of implantable device.
- the receiver may be physically coupled to a second implantable device, e.g., a device which serves as a platform for one or more physiological sensors.
- a device may be a lead, such as a cardiovascular lead.
- the cardiovascular lead may include one or more distinct physiological sensors, e.g., where the lead is a multi-sensor lead (MSL).
- Implantable devices of interest further include, but are not limited to: implantable pulse generators, neurostimulator devices, implantable loop recorders, etc.
- Receivers may further include a receiver element which serves to receive the signal of interest.
- the receiver may include a variety of different types of receiver elements, where the nature of the receiver element necessarily varies depending on the nature of the signal produced by the signal generation element.
- the receiver may include one or more electrodes for detecting signal emitted by the signal generation element.
- the receiver device may be provided with two electrodes that are dispersed at a predetermined distance. The predetermined distance may allow the electrodes to detect a differential voltage. The distance may vary, and in certain aspects, ranges from about 0.1 to about five cm, such as from about 0.5 to about 2.5 cm, e.g., about one cm.
- the first electrode is in contact with an electrically conductive body element, e.g., blood
- the second electrode is in contact with an electrically insulative body element relative to said conductive body element, e.g., adipose tissue (fat).
- a receiver that utilizes a single electrode is employed.
- the signal detection component may include one or more coils for detecting a signal emitted by the signal generation element.
- the signal detection component includes an acoustic detection element for detecting signal emitted by the signal generation element.
- a receiver may handle received data in various ways.
- the receiver simply retransmits the data to an external device, e.g., via conventional RF communication.
- the receiver processes the received data to determine whether to take some action such as operating an effector that is under its control, activating a visible or audible alarm, transmitting a control signal to an effector located elsewhere in the body, or the like.
- the receiver stores the received data for subsequent retransmission to another device or for use in processing of subsequent data, e.g., detecting a change in some parameter over time.
- the receivers may perform any combination of these and/or other operations using received data.
- the data that are recorded on the data storage element include at least one of, if not all of, time, date, and an identifier, e.g., global unique serial number, of each composition administered to a patient.
- the identifier may be the common name of the composition or a coded version thereof.
- the data recorded on the data storage element of the receiver may further include medical record information of the subject with which the receiver is associated, e.g., identifying information, such as but not limited to name, age, treatment record, etc.
- the data of interest include hemodynamic measurements.
- the data of interest include cardiac tissue properties.
- the data of interest include various physiologic metrics or parameters, e.g., pressure or volume measurements, temperature, activity, respiration rate, pH, etc.
- the receivers can be configured to have a very small size.
- the desired functionality of the receiver is achieved with one or more integrated circuits and a battery.
- aspects of the invention include receivers that have at least a receiver element, e.g., the form of one or more electrodes (such as two spaced apart electrodes) and a power generation element, e.g., a battery, where the battery may be rechargeable, etc., as mentioned above.
- the power generation element is converted to receive power wirelessly from an external location.
- Additional elements that may be present in the receiver include, but are not limited to: a signal demodulator, e.g., for decoding the signal emitted from the pharma-informatics enabled identifier; a signal transmitter, e.g., for sending a signal from the receiver to an external location; a data storage element, e.g., for storing data regarding a received signal, physiological parameter data, medical record data, etc.; a clock element, e.g., for associating a specific time with an event, such as receipt of a signal; a pre-amplifier; a microprocessor, e.g., for coordinating one or more of the different functionalities of the receiver.
- a signal demodulator e.g., for decoding the signal emitted from the pharma-informatics enabled identifier
- a signal transmitter e.g., for sending a signal from the receiver to an external location
- a data storage element e.g., for storing data regarding a
- implantable versions of the receiver will have a biologically compatible enclosure, two or more sense electrodes, a power source, which could either be a primary cell or rechargeable battery, or one that is powered by broadcast inductively to a coil.
- the receiver may also have circuitry consisting of: a demodulator to decode the transmitted signal, some storage to record events, a clock, and a way to transmit outside the body.
- the clock and transmit functionality may, in certain aspects, be omitted.
- the transmitter could be an RF link or conductive link to move information from local data storage to external data storage.
- aspects include structures that have electrodes opposed to the skin, the demodulator, storage, and power.
- the communication may be wireless or performed over one or more conductive media, e.g., wires, optical fibers, etc.
- the same electrodes are used for receiving and transmitting signals.
- One mode may be a wristwatch which is conductively in contact with the body. To move the data from the implant to the wristwatch, currents may be sent out the pads and received by the wristwatch.
- RF techniques for facilitating transmission out of the body that may be employed, such as inductive protocols that use coils.
- electric fields may be employed, using insulated electrodes, for example.
- the components or functional blocks of the present receivers are present on integrated circuits, where the integrated circuits include a number of distinct functional blocks, i.e., modules. Within a given receiver, at least some of, e.g., two or more, up to an including all of, the functional blocks may be present in a single integrated circuit in the receiver.
- single integrated circuit is meant a single circuit structure that includes all of the different functional blocks.
- the integrated circuit is a monolithic integrated circuit (also known as IC, microcircuit, microchip, silicon chip, computer chip or chip) that is a miniaturized electronic circuit (which may include semiconductor devices, as well as passive components) that has been manufactured in the surface of a thin substrate of semiconductor material.
- the integrated circuits of certain aspects of the present invention may be hybrid integrated circuits, which are miniaturized electronic circuits constructed of individual semiconductor devices, as well as passive components, bonded to a substrate or circuit board.
- the receivers exhibit reliable decoding of an encoded signal even in the presence of substantial noise and a low SNR.
- This functional aspect of the receivers of the invention may be provided via various schemes. Some such schemes include, for example, coherent demodulation, e.g., Costas loop demodulation, accurate low overhead iterative decoding, Forward Error Correction (FEC), and noise cancellation, e.g., as described in PCT application serial no. PCT/US2007/024225 titled “Active Signal Processing Personal Health Receivers,” and filed on Nov. 19, 2007; the disclosure of which is herein incorporated by reference.
- coherent demodulation e.g., Costas loop demodulation
- accurate low overhead iterative decoding e.g., Forward Error Correction (FEC)
- FEC Forward Error Correction
- noise cancellation e.g., as described in PCT application serial no. PCT/US2007/024225 titled “Active Signal Processing Personal Health Receivers,” and filed on Nov. 19, 2007; the disclosure of which is
- receivers of interest include, but are not limited to, those described in: WO 2006/116718; 60/866,581; 60/945,251; 60/956,694, 60/887,780 and WO 2006/116718; the disclosures of which are herein incorporated by reference.
- Various aspects include, for example, transmitting, via an in vivo transmitter, an encoded signal; facilitating, via a transbody functionality module, communication of the signal; and receiving, via a receiver, the encoded signal, as heretofore described.
- the method provides characteristics of the encoded signal, wherein the characteristics optimize power consumption to facilitate the receiver in at least one of the following: spending maximum time in an inactive mode, waking up quickly, and waking up during a period of high probability that the transmitter is present.
- beacon functionality such as facilitating, via a beacon functionality module, communication of the encoded signal; facilitating, via a frequency hopping functionality module, communication of the encoded signal; and facilitating, via a collision avoidance functionality module, communication of the encoded signal.
- Some functionality may include, for example, providing beacon wakeup functionality; providing beacon signal functionality; generating a continuous wave, single frequency tone; providing a first frequency that is different from a data signal which is at a second frequency; and modulating the encoded signal.
- various aspects may alternatively or optionally include steps related to frequency hopping generating random frequency hops on a narrow band transmitted signal.
- various aspects may alternatively or optionally include steps related to collision avoidance such as transmitting, via a first in vivo transmitter and a second in vivo transmitter, at different frequencies; modulating a duty cycle; retransmitting randomly; and spreading across a frequency spectrum.
- Modulating a duty cycle may include dithering the duty cycle and spreading among frequencies.
- Transmitting at different frequencies may comprise providing multiple band pass filtering by different devices wherein respective signals associated with different frequencies are filtered by respective band pass fillers.
- Various aspects may include an article, comprising, for example, a storage medium having instructions, that when executed by a computing platform, result in execution of a method of providing transbody communications employing communication channels.
- the method may comprise various steps/combinations of steps such as transmitting, via an in vivo transmitter, an encoded signal; facilitating, via a transbody functionality module, communication of the signal; and receiving, via a receiver, the encoded signal.
- steps such as transmitting, via an in vivo transmitter, an encoded signal; facilitating, via a transbody functionality module, communication of the signal; and receiving, via a receiver, the encoded signal.
- the receivers are part of a body associated system or network of sensors, receivers, and optionally other devices, both internal and external, which provide a variety of different types of information that is ultimately collected and processed by a processor, such as an external processor, which then can provide contextual data about a patient as output.
- a processor such as an external processor
- sensor may be a member of an in-body network of devices which can provide an output that includes data about pill ingestion, one or more physiological sensed parameters, implantable device operation, etc., to an external collector of the data.
- the external collector e.g., in the form of a health care network server, etc., of the data then combines this receiver provided data with additional relevant data about the patient, e.g., weight, weather, medical record data, etc., and may process this disparate data to provide highly specific and contextual patient specific data.
- Systems of the subject invention include, in certain aspects, a receiver and one or more pharma-informatics enabled active agent containing compositions.
- the pharma-informatics enabled pharmaceutical composition is an active agent-containing composition having an identifier stably associated therewith.
- the compositions are disrupted upon administration to a subject.
- the compositions are physically broken, e.g., dissolved, degraded, eroded, etc., following delivery to a body, e.g., via ingestion, injection, etc.
- the compositions of these aspects are distinguished from devices that are configured to be ingested and survive transit through the gastrointestinal tract substantially, if not completely, intact.
- the compositions include an identifier and an active agent/carrier component, where both of these components are present in a pharmaceutically acceptable vehicle.
- the identifiers of the compositions may vary depending on the particular aspect and intended application of the composition so long as they are activated (i.e., turned on) upon contact with a target physiological location, e.g., stomach.
- the identifier may be an identifier that emits a signal when it contacts a target body (i.e., physiological) site.
- the identifier may be an identifier that emits a signal when interrogated after it has been activated.
- the identifier may be any component or device that is capable of providing a detectable signal following activation, e.g., upon contact with the target site.
- the identifier emits a signal once the composition comes into contact with a physiological target site, e.g., as summarized above.
- a physiological target site e.g., as summarized above.
- a patient may ingest a pill that, upon contact with the stomach fluids, generates a detectable signal.
- compositions include an active agent/carrier component.
- active agent/carrier component is meant a composition, which may be a solid or fluid (e.g., liquid), which has an amount of active agent, e.g., a dosage, present in a pharmaceutically acceptable carrier.
- the active agent/carrier component may be referred to as a “dosage formulation.”
- Active agent includes any compound or mixture of compounds which produces a physiological result, e.g., a beneficial or useful result, upon contact with a living organism, e.g., a mammal, such as a human. Active agents are distinguishable from such components as vehicles, carriers, diluents, lubricants, binders and other formulating aids, and encapsulating or otherwise protective components.
- the active agent may be any molecule, as well as binding portion or fragment thereof, that is capable of modulating a biological process in a living subject.
- the active agent may be a substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication.
- the active agent may be a chemical substance, such as a narcotic or hallucinogen, which affects the central nervous system and causes changes in behavior.
- the active agent i.e., drug
- the target may be a number of different types of naturally occurring structures, where targets of interest include both intracellular and extracellular targets.
- targets of interest include both intracellular and extracellular targets.
- targets may be proteins, phospholipids, nucleic acids and the like, where proteins are of particular interest.
- Specific proteinaceous targets of interest include, without limitation, enzymes, e.g. kinases, phosphatases, reductases, cyclooxygenases, proteases and the like, targets comprising domains involved in protein-protein interactions, such as the SH2, SH3, PTB and PDZ domains, structural proteins, e.g. actin, tubulin, etc., membrane receptors, immunoglobulins, e.g. IgE, cell adhesion receptors, such as integrins, etc, ion channels, transmembrane pumps, transcription factors, signaling proteins, and the like.
- enzymes e.g. kinases, phosphata
- the active agent may include one or more functional groups necessary for structural interaction with the target, e.g., groups necessary for hydrophobic, hydrophilic, electrostatic or even covalent interactions, depending on the particular drug and its intended target.
- the drug moiety may include functional groups necessary for structural interaction with proteins, such as hydrogen bonding, hydrophobic-hydrophobic interactions, electrostatic interactions, etc., and may include at least an amine, amide, sulfhydryl, carbonyl, hydroxyl or carboxyl group, such as at least two of the functional chemical groups.
- Drugs of interest may include cyclical carbon or heterocyclic structures and/or aromatic or polyaromatic structures substituted with one or more of the above functional groups.
- drug moieties are structures found among biomolecules, including peptides, saccharides, fatty acids, steroids, purines, pyrimidines, derivatives, structural analogs or combinations thereof. Such compounds may be screened to identify those of interest, where a variety of different screening protocols are known in the art.
- the drugs may be derived from a naturally occurring or synthetic compound that may be obtained from a wide variety of sources, including libraries of synthetic or natural compounds. For example, numerous means are available for random and directed synthesis of a wide variety of organic compounds and biomolecules, including the preparation of randomized oligonucleotides and oligopeptides. Alternatively, libraries of natural compounds in the form of bacterial, fungal, plant and animal extracts are available or readily produced. Additionally, natural or synthetically produced libraries and compounds are readily modified through conventional chemical, physical and biochemical means, and may be used to produce combinatorial libraries. Known pharmacological agents may be subjected to directed or random chemical modifications, such as acylation, alkylation, esterification, amidification, etc. to produce structural analogs.
- the drug may be obtained from a library of naturally occurring or synthetic molecules, including a library of compounds produced through combinatorial means, i.e., a compound diversity combinatorial library.
- a library of compounds produced through combinatorial means i.e., a compound diversity combinatorial library.
- the drug moiety employed will have demonstrated some desirable activity in an appropriate screening assay for the activity.
- Combinatorial libraries, as well as methods for producing and screening such libraries, are known in the art and described in: U.S. Pat. Nos.
- cardiovascular agents include, but are not limited to: cardiovascular agents; pain-relief agents, e.g., analgesics, anesthetics, anti-inflammatory agents, etc.; nerve-acting agents; chemotherapeutic (e.g., anti-neoplastic) agents; etc.
- compositions of the invention further include a pharmaceutically acceptable vehicle (i.e., carrier).
- a pharmaceutically acceptable vehicle i.e., carrier
- Common carriers and excipients such as corn starch or gelatin, lactose, dextrose, sucrose, microcrystalline cellulose, kaolin, mannitol, dicalcium phosphate, sodium chloride, and alginic acid are of interest.
- Disintegrators commonly used in the formulations of the invention include croscarmellose, microcrystalline cellulose, corn starch, sodium starch glycolate and alginic acid.
- the systems include an external device which is distinct from the receiver (which may be implanted or topically applied in certain aspects), where this external device provides a number of functionalities.
- an apparatus can include the capacity to provide feedback and appropriate clinical regulation to the patient.
- Such a device can take any of a number of forms.
- the device can be configured to sit on the bed next to the patient, e.g., a bedside monitor.
- Other formats include, but are not limited to, PDAs, smart phones, home computers, etc.
- the device can read out the information described in more detail in other sections of the subject patent application, both from pharmaceutical ingestion reporting and from physiological sensing devices, such as is produced internally by a pacemaker device or a dedicated implant for detection of the pill.
- the purpose of the external apparatus is to get the data out of the patient and into an external device.
- One feature of the external apparatus is its ability to provide pharmacologic and physiologic information in a form that can be transmitted through a transmission medium, such as a telephone line, to a remote location such as a clinician or to a central monitoring agency.
- Systems of the invention enable a dynamic feedback and treatment loop of tracking medication timing and levels, measuring the response to therapy, and recommending altered dosing based on the physiology and molecular profiles of individual patients.
- a symptomatic heart failure patient takes multiple drugs daily, primarily with the goal of reducing the heart's workload and improving patient quality of life.
- Mainstays of therapy include angiotensin converting enzyme (ACE) inhibitors, ⁇ -blockers and diuretics.
- ACE angiotensin converting enzyme
- ⁇ -blockers ⁇ -blockers
- diuretics diuretics
- the systems of the invention may be employed to obtain an aggregate of information that includes sensor data and administration data.
- an aggregate of information that includes sensor data and administration data.
- a physiological index such as an activity index.
- heart rate goes up a bit
- respiration speeds up which may be employed as an indication that the person is being active. By calibrating this, the amount of calories the person is burning at that instant could be determined.
- a particular rhythmic set of pulses or multi-axis acceleration data can indicate that a person is walking up a set of stairs, and from that one can infer how much energy they are using.
- body fat measurement e.g. from impedance data
- an activity index generated from a combination of measured biomarkers to generate a physiological index useful for management of a weight loss or cardiovascular health program.
- This information can be combined with cardiac performance indicators to get a good picture of overall health, which can be combined with pharmaceutical therapy administration data.
- a particular pharmaceutical correlates with a small increase in body temperature, or a change in the electrocardiogram.
- the subject specific information that is collected using the systems of the invention may be transmitted to a location where it is combined with data from one or more additional individuals to provide a collection of data which is a composite of data collected from 2 or more, e.g., 5 or more, 10 or more, 25 or more, 50 or more, 100 or more, 1000 or more, etc., individuals.
- the composite data can then be manipulated, e.g., categorized according to different criteria, and made available to one or more different types of groups, e.g., patient groups, health care practitioner groups, etc., where the manipulation of data may be such as to limit the access of any given group to the type of data that group can access.
- data can be collected from 100 different individuals that are suffering from the same condition and taking the same medication.
- the data can be processed and employed to develop easy to follow displays regarding patient compliance with a pharmaceutical dosage regimen and general health.
- Patient members of the group can access this information and see how their compliance matches with other patient members of the group, and whether they are enjoying the benefits that others are experiencing.
- doctors can also be granted access to a manipulation of the composite data to see how their patients are matching up with patients of other doctors, and obtain useful information on how real patients respond to a given therapeutic treatment regimen.
- Additional functionalities can be provided to the groups given access to the composite data, where such functionalities may include, but are not limited to: ability to annotate data, chat functionalities, security privileges, etc.
- the system further includes an element for storing data, i.e., a data storage element, where this element is present on an external device, such as a bedside monitor, PDA, smart phone, etc.
- the data storage element is a computer readable medium.
- computer readable medium refers to any storage or transmission medium that participates in providing instructions and/or data to a computer for execution and/or processing. Examples of storage media include floppy disks, magnetic tape, CD-ROM, a hard disk drive, a ROM or integrated circuit, a magneto-optical disk, or a computer readable card such as a PCMCIA card and the like, whether or not such devices are internal or external to the computer.
- a file containing information may be “stored” on computer readable medium, where “storing” means recording information such that it is accessible and retrievable at a later date by a computer.
- “permanent memory” refers to memory that is permanent. Permanent memory is not erased by termination of the electrical supply to a computer or processor. Computer hard-drive ROM (i.e. ROM not used as virtual memory), CD-ROM, floppy disk and DVD are all examples of permanent memory. Random Access Memory (RAM) is an example of non-permanent memory.
- a file in permanent memory may be editable and re-writable.
- the invention also provides computer executable instructions (i.e., programming) for performing the above methods.
- the computer executable instructions are present on a computer readable medium. Accordingly, the invention provides a computer readable medium containing programming for use in detecting and processing a signal generated by a composition of the invention, e.g., as reviewed above.
- the systems include one or more of: a data storage element, a data processing element, a data display element, data transmission element, a notification mechanism, and a user interface.
- a data storage element e.g., a hard disk drive, a solid state drive, etc.
- the above described systems are reviewed in terms of communication between an identifier on a pharmaceutical composition and a receiver.
- the systems are not so limited.
- the systems are composed of two or more different modules that communicate with each other, e.g., using the transmitter/receiver functionalities as reviewed above, e.g., using the monopole transmitter (e.g., antenna) structures as described above.
- the above identifier elements may be incorporated into any of a plurality of different devices, e.g., to provide a communications system between two self-powered devices in the body, where the self-powered devices may be sensors, data receivers and storage elements, effectors, etc.
- one of these devices may be a sensor and the other may be a communication hub for communication to the outside world.
- This inventive aspect may take a number of forms. There can be many sensors, many senders and one receiver. They can be transceivers so both of these can take turns sending and receiving according to known communication protocols.
- the means of communication between the two or more individual devices is the mono polar system, e.g., as described above.
- each of these senders may be configured to take turns sending a high frequency signal into the body using a monopole pulling charge into and out of the body which is a large capacitor and a conductor.
- the receiver a monopole receiver is detecting at that frequency the charge going into and out of the body and decoding an encrypted signal such as an amplitude modulated signal or frequency modulated signal.
- This aspect of the present invention has broad uses. For example, multiple sensors can be placed and implanted on various parts of the body that measure position or acceleration. Without having wires connecting to a central hub, they can communicate that information through a communication medium.
- an effective amount of a composition of the invention is administered to a subject in need of the active agent present in the composition, where “effective amount” means a dosage sufficient to produce the desired result, e.g. an improvement in a disease condition or the symptoms associated therewith, the accomplishment of a desired physiological change, etc.
- the amount that is administered may also be viewed as a therapeutically effective amount.
- a “therapeutically effective amount” means the amount that, when administered to a subject for treating a disease, is sufficient to effect treatment for that disease.
- compositions may be administered to the subject using any convenient means capable of producing the desired result, where the administration route depends, at least in part, on the particular format of the composition, e.g., as reviewed above.
- the compositions can be formatted into a variety of formulations for therapeutic administration, including but not limited to solid, semi solid or liquid, such as tablets, capsules, powders, granules, ointments, solutions, suppositories and injections.
- administration of the compositions can be achieved in various ways, including, but not limited to: oral, buccal, rectal, parenteral, intraperitoneal, intradermal, transdermal, intracheal, etc., administration.
- a given composition may be administered alone or in combination with other pharmaceutically active compounds, e.g., which may also be compositions having signal generation elements stably associated therewith.
- disease conditions include, but are not limited to: cardiovascular diseases, cellular proliferative diseases, such as neoplastic diseases, autoimmune diseases, hormonal abnormality diseases, infectious diseases, pain management, and the like.
- treatment is meant at least an amelioration of the symptoms associated with the disease condition afflicting the subject, where amelioration is used in a broad sense to refer to at least a reduction in the magnitude of a parameter, e.g. symptom, associated with the pathological condition being treated.
- amelioration also includes situations where the pathological condition, or at least symptoms associated therewith, are completely inhibited, e.g. prevented from happening, or stopped, e.g. terminated, such that the subject no longer suffers from the pathological condition, or at least the symptoms that characterize the pathological condition.
- treating” or “treatment” of a disease includes preventing the disease from occurring in an animal that may be predisposed to the disease but does not yet experience or exhibit symptoms of the disease (prophylactic treatment), inhibiting the disease (slowing or arresting its development), providing relief from the symptoms or side-effects of the disease (including palliative treatment), and relieving the disease (causing regression of the disease).
- a “disease” includes pain.
- mammals or “mammalian,” where these terms are used broadly to describe organisms which are within the class mammalia, including the orders carnivore (e.g., dogs and cats), rodentia (e.g., mice, guinea pigs, and rats), and primates (e.g., humans, chimpanzees, and monkeys). In representative aspects, the subjects will be humans.
- carnivore e.g., dogs and cats
- rodentia e.g., mice, guinea pigs, and rats
- primates e.g., humans, chimpanzees, and monkeys.
- the subjects will be humans.
- the subject methods are methods of managing a disease condition, e.g., over an extended period of time, such as 1 week or longer, 1 month or longer, 6 months or longer, 1 year or longer, 2 years or longer, 5 years or longer, etc.
- the subject methods may be employed in conjunction with one or more additional disease management protocols, e.g., electrostimulation based protocols in cardiovascular disease management, such as pacing protocols, cardiac resynchronization protocols, etc; lifestyle, such a diet and/or exercise regimens for a variety of different disease conditions; etc.
- the methods include modulating a therapeutic regimen based data obtained from the compositions.
- data may be obtained which includes information about patient compliance with a prescribed therapeutic regimen.
- This data with or without additional physiological data, e.g., obtained using one or more sensors, such as the sensor devices described above, may be employed, e.g., with appropriate decision tools as desired, to make determinations of whether a given treatment regimen should be maintained or modified in some way, e.g., by modification of a medication regimen and/or implant activity regimen.
- methods of invention include methods in which a therapeutic regimen is modified based on signals obtained from the composition(s).
- compositions include an active agent, an identifier element and a pharmaceutically acceptable carrier.
- the identifier emits a signal in response to an interrogation
- the identifier is interrogate, e.g., by a wand or other suitable interrogation device, to obtain a signal.
- the obtained signal is then employed to determine historical information about the composition, e.g., source, chain of custody, etc.
- the methods generally include obtaining the signal generation element of the composition, e.g., by retrieving it from a subject that has ingested the composition, and then determining the history of the composition from obtained signal generation element.
- the signal generation element includes an engraved identifier, e.g., barcode or other type of identifier
- the engraved identifier may be retrieved from a subject that has ingested the composition and then read to identify at least some aspect of the history of the composition, such as last known purchaser, additional purchasers in the chain of custody of the composition, manufacturer, handling history, etc.
- this determining step may include accessing a database or analogous compilation of stored history for the composition.
- Medical aspects of the present invention provide the clinician an important new tool in their therapeutic armamentarium: automatic detection and identification of pharmaceutical agents actually delivered into the body.
- the applications of this new information device and system are multi-fold. Applications include, but are not limited to: (1) monitoring patient compliance with prescribed therapeutic regimens; (2) tailoring therapeutic regimens based on patient compliance; (3) monitoring patient compliance in clinical trials; (4) monitoring usage of controlled substances; and the like.
- Kits may include one or more receivers of the invention, as described above.
- the kits may include one or more dosage compositions, e.g., pharma-informatics enabled dosage compositions.
- the dosage amount of the one or more pharmacological agents provided in a kit may be sufficient for a single application or for multiple applications. Accordingly, in certain aspects of the subject kits a single dosage amount of a pharmacological agent is present and in certain other aspects multiple dosage amounts of a pharmacological agent may be present in a kit.
- pharmacological agent such may be packaged in a single container, e.g., a single tube, bottle, vial, and the like, or one or more dosage amounts may be individually packaged such that certain kits may have more than one container of a pharmacological agent.
- Suitable means for delivering one or more pharmacological agents to a subject may also be provided in a subject kit.
- the particular delivery means provided in a kit is dictated by the particular pharmacological agent employed, as describe above, e.g., the particular form of the agent such as whether the pharmacological agent is formulated into preparations in solid, semi solid, liquid or gaseous forms, such as tablets, capsules, powders, granules, ointments, solutions, suppositories, injections, inhalants and aerosols, and the like, and the particular mode of administration of the agent, e.g., whether oral, buccal, rectal, parenteral, intraperitoneal, intradermal, transdermal, intracheal, etc. Accordingly, certain systems may include a suppository applicator, syringe, I.V. bag and tubing, electrode, etc.
- kits may also include an external monitor device, e.g., as described above, which may provide for communication with a remote location, e.g., a doctor's office, a central facility etc., which obtains and processes data obtained about the usage of the composition.
- a remote location e.g., a doctor's office, a central facility etc.
- kits may include a smart parenteral delivery system that provides specific identification and detection of parenteral beneficial agents or beneficial agents taken into the body through other methods, for example, through the use of a syringe, inhaler, or other device that administers medicine, such as described in copending application Ser. No. 60/819,750; the disclosure of which is herein incorporated by reference.
- the subject kits may also include instructions for how to practice the subject methods using the components of the kit.
- the instructions may be recorded on a suitable recording medium or substrate.
- the instructions may be printed on a substrate, such as paper or plastic, etc.
- the instructions may be present in the kits as a package insert, in the labeling of the container of the kit or components thereof (i.e., associated with the packaging or sub-packaging) etc.
- the instructions are present as an electronic storage data file present on a suitable computer readable storage medium, e.g. CD-ROM, diskette, etc.
- the actual instructions are not present in the kit, but means for obtaining the instructions from a remote source, e.g. via the internet, are provided.
- An example of this aspect is a kit that includes a web address where the instructions can be viewed and/or from which the instructions can be downloaded. As with the instructions, this means for obtaining the instructions is recorded on a suitable substrate.
- kits may be packaged in suitable packaging to maintain sterility.
- the components of the kit are packaged in a kit containment element to make a single, easily handled unit, where the kit containment element, e.g., box or analogous structure, may or may not be an airtight container, e.g., to further preserve the sterility of some or all of the components of the kit.
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Cited By (148)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080020037A1 (en) * | 2006-07-11 | 2008-01-24 | Robertson Timothy L | Acoustic Pharma-Informatics System |
US20080284599A1 (en) * | 2005-04-28 | 2008-11-20 | Proteus Biomedical, Inc. | Pharma-Informatics System |
US8036748B2 (en) | 2008-11-13 | 2011-10-11 | Proteus Biomedical, Inc. | Ingestible therapy activator system and method |
US8054140B2 (en) | 2006-10-17 | 2011-11-08 | Proteus Biomedical, Inc. | Low voltage oscillator for medical devices |
US8115618B2 (en) | 2007-05-24 | 2012-02-14 | Proteus Biomedical, Inc. | RFID antenna for in-body device |
US8114021B2 (en) | 2008-12-15 | 2012-02-14 | Proteus Biomedical, Inc. | Body-associated receiver and method |
WO2012042437A2 (en) | 2010-09-30 | 2012-04-05 | Koninklijke Philips Electronics N.V. | Body worn sensors network with redundant parameter prioritization and temporal alignment |
US8258962B2 (en) | 2008-03-05 | 2012-09-04 | Proteus Biomedical, Inc. | Multi-mode communication ingestible event markers and systems, and methods of using the same |
US20120315863A1 (en) * | 2011-06-07 | 2012-12-13 | Olympus Corporation | Wireless communication terminal |
US8540664B2 (en) | 2009-03-25 | 2013-09-24 | Proteus Digital Health, Inc. | Probablistic pharmacokinetic and pharmacodynamic modeling |
US8540633B2 (en) | 2008-08-13 | 2013-09-24 | Proteus Digital Health, Inc. | Identifier circuits for generating unique identifiable indicators and techniques for producing same |
US8545402B2 (en) | 2009-04-28 | 2013-10-01 | Proteus Digital Health, Inc. | Highly reliable ingestible event markers and methods for using the same |
US8547248B2 (en) | 2005-09-01 | 2013-10-01 | Proteus Digital Health, Inc. | Implantable zero-wire communications system |
US8558563B2 (en) | 2009-08-21 | 2013-10-15 | Proteus Digital Health, Inc. | Apparatus and method for measuring biochemical parameters |
US8583227B2 (en) | 2008-12-11 | 2013-11-12 | Proteus Digital Health, Inc. | Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same |
US8597186B2 (en) | 2009-01-06 | 2013-12-03 | Proteus Digital Health, Inc. | Pharmaceutical dosages delivery system |
US8718193B2 (en) | 2006-11-20 | 2014-05-06 | Proteus Digital Health, Inc. | Active signal processing personal health signal receivers |
US8730031B2 (en) | 2005-04-28 | 2014-05-20 | Proteus Digital Health, Inc. | Communication system using an implantable device |
US8784308B2 (en) | 2009-12-02 | 2014-07-22 | Proteus Digital Health, Inc. | Integrated ingestible event marker system with pharmaceutical product |
US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US8836513B2 (en) | 2006-04-28 | 2014-09-16 | Proteus Digital Health, Inc. | Communication system incorporated in an ingestible product |
US8858432B2 (en) | 2007-02-01 | 2014-10-14 | Proteus Digital Health, Inc. | Ingestible event marker systems |
US8868453B2 (en) | 2009-11-04 | 2014-10-21 | Proteus Digital Health, Inc. | System for supply chain management |
US8912908B2 (en) | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
US8932221B2 (en) | 2007-03-09 | 2015-01-13 | Proteus Digital Health, Inc. | In-body device having a multi-directional transmitter |
US8945005B2 (en) | 2006-10-25 | 2015-02-03 | Proteus Digital Health, Inc. | Controlled activation ingestible identifier |
US8956288B2 (en) | 2007-02-14 | 2015-02-17 | Proteus Digital Health, Inc. | In-body power source having high surface area electrode |
US8961412B2 (en) | 2007-09-25 | 2015-02-24 | Proteus Digital Health, Inc. | In-body device with virtual dipole signal amplification |
US20150095274A1 (en) * | 2013-10-02 | 2015-04-02 | Qualcomm Incorporated | Method and apparatus for producing programmable probability distribution function of pseudo-random numbers |
US9014779B2 (en) | 2010-02-01 | 2015-04-21 | Proteus Digital Health, Inc. | Data gathering system |
US9031653B2 (en) | 2012-07-26 | 2015-05-12 | Nyxoah SA | Internal resonance matching between an implanted device and an external device |
US9107806B2 (en) | 2010-11-22 | 2015-08-18 | Proteus Digital Health, Inc. | Ingestible device with pharmaceutical product |
US9149423B2 (en) | 2009-05-12 | 2015-10-06 | Proteus Digital Health, Inc. | Ingestible event markers comprising an ingestible component |
US9198608B2 (en) | 2005-04-28 | 2015-12-01 | Proteus Digital Health, Inc. | Communication system incorporated in a container |
US9235683B2 (en) | 2011-11-09 | 2016-01-12 | Proteus Digital Health, Inc. | Apparatus, system, and method for managing adherence to a regimen |
US9270503B2 (en) | 2013-09-20 | 2016-02-23 | Proteus Digital Health, Inc. | Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping |
US9268909B2 (en) | 2012-10-18 | 2016-02-23 | Proteus Digital Health, Inc. | Apparatus, system, and method to adaptively optimize power dissipation and broadcast power in a power source for a communication device |
US9270025B2 (en) | 2007-03-09 | 2016-02-23 | Proteus Digital Health, Inc. | In-body device having deployable antenna |
US9271897B2 (en) | 2012-07-23 | 2016-03-01 | Proteus Digital Health, Inc. | Techniques for manufacturing ingestible event markers comprising an ingestible component |
US9439566B2 (en) | 2008-12-15 | 2016-09-13 | Proteus Digital Health, Inc. | Re-wearable wireless device |
US9439599B2 (en) | 2011-03-11 | 2016-09-13 | Proteus Digital Health, Inc. | Wearable personal body associated device with various physical configurations |
EP3070982A1 (de) * | 2015-03-19 | 2016-09-21 | Albert-Ludwigs-Universität Freiburg | Empfangseinrichtung und verfahren zum betreiben einer empfangseinrichtung |
US9526909B2 (en) | 2014-08-28 | 2016-12-27 | Cardiac Pacemakers, Inc. | Medical device with triggered blanking period |
US9577864B2 (en) | 2013-09-24 | 2017-02-21 | Proteus Digital Health, Inc. | Method and apparatus for use with received electromagnetic signal at a frequency not known exactly in advance |
US9592391B2 (en) | 2014-01-10 | 2017-03-14 | Cardiac Pacemakers, Inc. | Systems and methods for detecting cardiac arrhythmias |
US9597487B2 (en) | 2010-04-07 | 2017-03-21 | Proteus Digital Health, Inc. | Miniature ingestible device |
CN106534854A (zh) * | 2011-03-07 | 2017-03-22 | 杜比国际公司 | 编码和解码图像的方法、编码和解码设备 |
US9603550B2 (en) | 2008-07-08 | 2017-03-28 | Proteus Digital Health, Inc. | State characterization based on multi-variate data fusion techniques |
US9659423B2 (en) | 2008-12-15 | 2017-05-23 | Proteus Digital Health, Inc. | Personal authentication apparatus system and method |
US9669230B2 (en) | 2015-02-06 | 2017-06-06 | Cardiac Pacemakers, Inc. | Systems and methods for treating cardiac arrhythmias |
US9694189B2 (en) | 2014-08-06 | 2017-07-04 | Cardiac Pacemakers, Inc. | Method and apparatus for communicating between medical devices |
US9757570B2 (en) | 2014-08-06 | 2017-09-12 | Cardiac Pacemakers, Inc. | Communications in a medical device system |
US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
US9808631B2 (en) | 2014-08-06 | 2017-11-07 | Cardiac Pacemakers, Inc. | Communication between a plurality of medical devices using time delays between communication pulses to distinguish between symbols |
US9853743B2 (en) | 2015-08-20 | 2017-12-26 | Cardiac Pacemakers, Inc. | Systems and methods for communication between medical devices |
US9883819B2 (en) | 2009-01-06 | 2018-02-06 | Proteus Digital Health, Inc. | Ingestion-related biofeedback and personalized medical therapy method and system |
US9956414B2 (en) | 2015-08-27 | 2018-05-01 | Cardiac Pacemakers, Inc. | Temporal configuration of a motion sensor in an implantable medical device |
US9968787B2 (en) | 2015-08-27 | 2018-05-15 | Cardiac Pacemakers, Inc. | Spatial configuration of a motion sensor in an implantable medical device |
US10029107B1 (en) | 2017-01-26 | 2018-07-24 | Cardiac Pacemakers, Inc. | Leadless device with overmolded components |
US10046167B2 (en) | 2015-02-09 | 2018-08-14 | Cardiac Pacemakers, Inc. | Implantable medical device with radiopaque ID tag |
US10050700B2 (en) | 2015-03-18 | 2018-08-14 | Cardiac Pacemakers, Inc. | Communications in a medical device system with temporal optimization |
US10065041B2 (en) | 2015-10-08 | 2018-09-04 | Cardiac Pacemakers, Inc. | Devices and methods for adjusting pacing rates in an implantable medical device |
US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
US10092760B2 (en) | 2015-09-11 | 2018-10-09 | Cardiac Pacemakers, Inc. | Arrhythmia detection and confirmation |
US10137305B2 (en) | 2015-08-28 | 2018-11-27 | Cardiac Pacemakers, Inc. | Systems and methods for behaviorally responsive signal detection and therapy delivery |
US10159842B2 (en) | 2015-08-28 | 2018-12-25 | Cardiac Pacemakers, Inc. | System and method for detecting tamponade |
US10175376B2 (en) | 2013-03-15 | 2019-01-08 | Proteus Digital Health, Inc. | Metal detector apparatus, system, and method |
US10187121B2 (en) | 2016-07-22 | 2019-01-22 | Proteus Digital Health, Inc. | Electromagnetic sensing and detection of ingestible event markers |
US10183170B2 (en) | 2015-12-17 | 2019-01-22 | Cardiac Pacemakers, Inc. | Conducted communication in a medical device system |
US10213610B2 (en) | 2015-03-18 | 2019-02-26 | Cardiac Pacemakers, Inc. | Communications in a medical device system with link quality assessment |
US10223905B2 (en) | 2011-07-21 | 2019-03-05 | Proteus Digital Health, Inc. | Mobile device and system for detection and communication of information received from an ingestible device |
US10220213B2 (en) | 2015-02-06 | 2019-03-05 | Cardiac Pacemakers, Inc. | Systems and methods for safe delivery of electrical stimulation therapy |
US10226631B2 (en) | 2015-08-28 | 2019-03-12 | Cardiac Pacemakers, Inc. | Systems and methods for infarct detection |
WO2019108787A1 (en) * | 2017-11-29 | 2019-06-06 | Medtronic, Inc. | Tissue conduction communication between devices |
US10328272B2 (en) | 2016-05-10 | 2019-06-25 | Cardiac Pacemakers, Inc. | Retrievability for implantable medical devices |
US10350423B2 (en) | 2016-02-04 | 2019-07-16 | Cardiac Pacemakers, Inc. | Delivery system with force sensor for leadless cardiac device |
US10357159B2 (en) | 2015-08-20 | 2019-07-23 | Cardiac Pacemakers, Inc | Systems and methods for communication between medical devices |
US10391319B2 (en) | 2016-08-19 | 2019-08-27 | Cardiac Pacemakers, Inc. | Trans septal implantable medical device |
US10398161B2 (en) | 2014-01-21 | 2019-09-03 | Proteus Digital Heal Th, Inc. | Masticable ingestible product and communication system therefor |
US10413733B2 (en) | 2016-10-27 | 2019-09-17 | Cardiac Pacemakers, Inc. | Implantable medical device with gyroscope |
US10426962B2 (en) | 2016-07-07 | 2019-10-01 | Cardiac Pacemakers, Inc. | Leadless pacemaker using pressure measurements for pacing capture verification |
US10434317B2 (en) | 2016-10-31 | 2019-10-08 | Cardiac Pacemakers, Inc. | Systems and methods for activity level pacing |
US10434314B2 (en) | 2016-10-27 | 2019-10-08 | Cardiac Pacemakers, Inc. | Use of a separate device in managing the pace pulse energy of a cardiac pacemaker |
US10463305B2 (en) | 2016-10-27 | 2019-11-05 | Cardiac Pacemakers, Inc. | Multi-device cardiac resynchronization therapy with timing enhancements |
US10512784B2 (en) | 2016-06-27 | 2019-12-24 | Cardiac Pacemakers, Inc. | Cardiac therapy system using subcutaneously sensed P-waves for resynchronization pacing management |
US10529044B2 (en) | 2010-05-19 | 2020-01-07 | Proteus Digital Health, Inc. | Tracking and delivery confirmation of pharmaceutical products |
US10561330B2 (en) | 2016-10-27 | 2020-02-18 | Cardiac Pacemakers, Inc. | Implantable medical device having a sense channel with performance adjustment |
US10583301B2 (en) | 2016-11-08 | 2020-03-10 | Cardiac Pacemakers, Inc. | Implantable medical device for atrial deployment |
US10583303B2 (en) | 2016-01-19 | 2020-03-10 | Cardiac Pacemakers, Inc. | Devices and methods for wirelessly recharging a rechargeable battery of an implantable medical device |
US10617874B2 (en) | 2016-10-31 | 2020-04-14 | Cardiac Pacemakers, Inc. | Systems and methods for activity level pacing |
US10632313B2 (en) | 2016-11-09 | 2020-04-28 | Cardiac Pacemakers, Inc. | Systems, devices, and methods for setting cardiac pacing pulse parameters for a cardiac pacing device |
US10639486B2 (en) | 2016-11-21 | 2020-05-05 | Cardiac Pacemakers, Inc. | Implantable medical device with recharge coil |
US10668294B2 (en) | 2016-05-10 | 2020-06-02 | Cardiac Pacemakers, Inc. | Leadless cardiac pacemaker configured for over the wire delivery |
US10688304B2 (en) | 2016-07-20 | 2020-06-23 | Cardiac Pacemakers, Inc. | Method and system for utilizing an atrial contraction timing fiducial in a leadless cardiac pacemaker system |
US10722720B2 (en) | 2014-01-10 | 2020-07-28 | Cardiac Pacemakers, Inc. | Methods and systems for improved communication between medical devices |
US10737102B2 (en) | 2017-01-26 | 2020-08-11 | Cardiac Pacemakers, Inc. | Leadless implantable device with detachable fixation |
US10758724B2 (en) | 2016-10-27 | 2020-09-01 | Cardiac Pacemakers, Inc. | Implantable medical device delivery system with integrated sensor |
US10758737B2 (en) | 2016-09-21 | 2020-09-01 | Cardiac Pacemakers, Inc. | Using sensor data from an intracardially implanted medical device to influence operation of an extracardially implantable cardioverter |
US10765871B2 (en) | 2016-10-27 | 2020-09-08 | Cardiac Pacemakers, Inc. | Implantable medical device with pressure sensor |
US10780278B2 (en) | 2016-08-24 | 2020-09-22 | Cardiac Pacemakers, Inc. | Integrated multi-device cardiac resynchronization therapy using P-wave to pace timing |
US10821288B2 (en) | 2017-04-03 | 2020-11-03 | Cardiac Pacemakers, Inc. | Cardiac pacemaker with pacing pulse energy adjustment based on sensed heart rate |
US10835753B2 (en) | 2017-01-26 | 2020-11-17 | Cardiac Pacemakers, Inc. | Intra-body device communication with redundant message transmission |
US10870008B2 (en) | 2016-08-24 | 2020-12-22 | Cardiac Pacemakers, Inc. | Cardiac resynchronization using fusion promotion for timing management |
US10874861B2 (en) | 2018-01-04 | 2020-12-29 | Cardiac Pacemakers, Inc. | Dual chamber pacing without beat-to-beat communication |
US10881869B2 (en) | 2016-11-21 | 2021-01-05 | Cardiac Pacemakers, Inc. | Wireless re-charge of an implantable medical device |
US10881863B2 (en) | 2016-11-21 | 2021-01-05 | Cardiac Pacemakers, Inc. | Leadless cardiac pacemaker with multimode communication |
US10894163B2 (en) | 2016-11-21 | 2021-01-19 | Cardiac Pacemakers, Inc. | LCP based predictive timing for cardiac resynchronization |
US10905886B2 (en) | 2015-12-28 | 2021-02-02 | Cardiac Pacemakers, Inc. | Implantable medical device for deployment across the atrioventricular septum |
US10905889B2 (en) | 2016-09-21 | 2021-02-02 | Cardiac Pacemakers, Inc. | Leadless stimulation device with a housing that houses internal components of the leadless stimulation device and functions as the battery case and a terminal of an internal battery |
US10905872B2 (en) | 2017-04-03 | 2021-02-02 | Cardiac Pacemakers, Inc. | Implantable medical device with a movable electrode biased toward an extended position |
US10918875B2 (en) | 2017-08-18 | 2021-02-16 | Cardiac Pacemakers, Inc. | Implantable medical device with a flux concentrator and a receiving coil disposed about the flux concentrator |
US10994145B2 (en) | 2016-09-21 | 2021-05-04 | Cardiac Pacemakers, Inc. | Implantable cardiac monitor |
US11052258B2 (en) | 2017-12-01 | 2021-07-06 | Cardiac Pacemakers, Inc. | Methods and systems for detecting atrial contraction timing fiducials within a search window from a ventricularly implanted leadless cardiac pacemaker |
US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
US11058880B2 (en) | 2018-03-23 | 2021-07-13 | Medtronic, Inc. | VFA cardiac therapy for tachycardia |
US11065459B2 (en) | 2017-08-18 | 2021-07-20 | Cardiac Pacemakers, Inc. | Implantable medical device with pressure sensor |
US11071870B2 (en) | 2017-12-01 | 2021-07-27 | Cardiac Pacemakers, Inc. | Methods and systems for detecting atrial contraction timing fiducials and determining a cardiac interval from a ventricularly implanted leadless cardiac pacemaker |
US11116988B2 (en) | 2016-03-31 | 2021-09-14 | Cardiac Pacemakers, Inc. | Implantable medical device with rechargeable battery |
US11147979B2 (en) | 2016-11-21 | 2021-10-19 | Cardiac Pacemakers, Inc. | Implantable medical device with a magnetically permeable housing and an inductive coil disposed about the housing |
US11149123B2 (en) | 2013-01-29 | 2021-10-19 | Otsuka Pharmaceutical Co., Ltd. | Highly-swellable polymeric films and compositions comprising the same |
US11158149B2 (en) | 2013-03-15 | 2021-10-26 | Otsuka Pharmaceutical Co., Ltd. | Personal authentication apparatus system and method |
US11185703B2 (en) | 2017-11-07 | 2021-11-30 | Cardiac Pacemakers, Inc. | Leadless cardiac pacemaker for bundle of his pacing |
US11207532B2 (en) | 2017-01-04 | 2021-12-28 | Cardiac Pacemakers, Inc. | Dynamic sensing updates using postural input in a multiple device cardiac rhythm management system |
US11207527B2 (en) | 2016-07-06 | 2021-12-28 | Cardiac Pacemakers, Inc. | Method and system for determining an atrial contraction timing fiducial in a leadless cardiac pacemaker system |
US11213676B2 (en) | 2019-04-01 | 2022-01-04 | Medtronic, Inc. | Delivery systems for VfA cardiac therapy |
US11234280B2 (en) | 2017-11-29 | 2022-01-25 | Samsung Electronics Co., Ltd. | Method for RF communication connection using electronic device and user touch input |
US11235163B2 (en) | 2017-09-20 | 2022-02-01 | Cardiac Pacemakers, Inc. | Implantable medical device with multiple modes of operation |
US11235159B2 (en) | 2018-03-23 | 2022-02-01 | Medtronic, Inc. | VFA cardiac resynchronization therapy |
US11235161B2 (en) | 2018-09-26 | 2022-02-01 | Medtronic, Inc. | Capture in ventricle-from-atrium cardiac therapy |
US11260216B2 (en) | 2017-12-01 | 2022-03-01 | Cardiac Pacemakers, Inc. | Methods and systems for detecting atrial contraction timing fiducials during ventricular filling from a ventricularly implanted leadless cardiac pacemaker |
US11285326B2 (en) | 2015-03-04 | 2022-03-29 | Cardiac Pacemakers, Inc. | Systems and methods for treating cardiac arrhythmias |
US11305127B2 (en) | 2019-08-26 | 2022-04-19 | Medtronic Inc. | VfA delivery and implant region detection |
US11400296B2 (en) | 2018-03-23 | 2022-08-02 | Medtronic, Inc. | AV synchronous VfA cardiac therapy |
US11529071B2 (en) | 2016-10-26 | 2022-12-20 | Otsuka Pharmaceutical Co., Ltd. | Methods for manufacturing capsules with ingestible event markers |
US11529523B2 (en) | 2018-01-04 | 2022-12-20 | Cardiac Pacemakers, Inc. | Handheld bridge device for providing a communication bridge between an implanted medical device and a smartphone |
WO2023028164A1 (en) * | 2021-08-24 | 2023-03-02 | Canary Medical Switzerland Ag | Implantable medical device with sensing and communication functionality |
US11612321B2 (en) | 2007-11-27 | 2023-03-28 | Otsuka Pharmaceutical Co., Ltd. | Transbody communication systems employing communication channels |
US11679265B2 (en) | 2019-02-14 | 2023-06-20 | Medtronic, Inc. | Lead-in-lead systems and methods for cardiac therapy |
US11697025B2 (en) | 2019-03-29 | 2023-07-11 | Medtronic, Inc. | Cardiac conduction system capture |
US11712188B2 (en) | 2019-05-07 | 2023-08-01 | Medtronic, Inc. | Posterior left bundle branch engagement |
US11744481B2 (en) | 2013-03-15 | 2023-09-05 | Otsuka Pharmaceutical Co., Ltd. | System, apparatus and methods for data collection and assessing outcomes |
US11813464B2 (en) | 2020-07-31 | 2023-11-14 | Medtronic, Inc. | Cardiac conduction system evaluation |
US11813463B2 (en) | 2017-12-01 | 2023-11-14 | Cardiac Pacemakers, Inc. | Leadless cardiac pacemaker with reversionary behavior |
US11813466B2 (en) | 2020-01-27 | 2023-11-14 | Medtronic, Inc. | Atrioventricular nodal stimulation |
US11911168B2 (en) | 2020-04-03 | 2024-02-27 | Medtronic, Inc. | Cardiac conduction system therapy benefit determination |
US11928614B2 (en) | 2006-05-02 | 2024-03-12 | Otsuka Pharmaceutical Co., Ltd. | Patient customized therapeutic regimens |
US11951313B2 (en) | 2018-11-17 | 2024-04-09 | Medtronic, Inc. | VFA delivery systems and methods |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8315224B2 (en) * | 2010-01-22 | 2012-11-20 | General Electric Company | Methods and systems for reuse of radio resources in medical telemetry networks |
US20130129869A1 (en) | 2011-11-23 | 2013-05-23 | Hooman Hafezi | Compositions comprising a shelf-life stability component |
KR101916418B1 (ko) | 2012-11-29 | 2018-11-08 | 삼성전자주식회사 | 수신 장치의 소비 전력 저감 방법 및 소비 전력 저감 장치 |
CN105892317A (zh) * | 2016-03-31 | 2016-08-24 | 创领心律管理医疗器械(上海)有限公司 | 植入式医疗设备及其数据输出和接收方法以及通信机制 |
TWI667860B (zh) | 2018-02-09 | 2019-08-01 | 鉅旺生技股份有限公司 | 植入式醫材遠距離無線充電強化結構 |
Citations (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3642008A (en) * | 1968-09-25 | 1972-02-15 | Medical Plastics Inc | Ground electrode and test circuit |
US3719183A (en) * | 1970-03-05 | 1973-03-06 | H Schwartz | Method for detecting blockage or insufficiency of pancreatic exocrine function |
US3799802A (en) * | 1966-06-28 | 1974-03-26 | F Schneble | Plated through hole printed circuit boards |
US4077397A (en) * | 1974-10-07 | 1978-03-07 | Baxter Travenol Laboratories, Inc. | Diagnostic electrode assembly |
US4077398A (en) * | 1974-10-07 | 1978-03-07 | Baxter Travenol Laboratories, Inc. | Diagnostic electrode assembly |
US4251795A (en) * | 1977-11-29 | 1981-02-17 | Asahi Kasei Kogyo Kabushiki Kaisha | Semiconductor magnetoresistive element having a differential effect |
US4494950A (en) * | 1982-01-19 | 1985-01-22 | The Johns Hopkins University | Plural module medication delivery system |
US4578061A (en) * | 1980-10-28 | 1986-03-25 | Lemelson Jerome H | Injection catheter and method |
US4635641A (en) * | 1985-10-16 | 1987-01-13 | Murray Electronics Associates Limited | Multi-element electrode |
US4681111A (en) * | 1985-04-05 | 1987-07-21 | Siemens-Pacesetter, Inc. | Analog and digital telemetry system for an implantable device |
US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
US5281287A (en) * | 1989-07-21 | 1994-01-25 | Iomed, Inc. | Method of making a hydratable bioelectrode |
US5394882A (en) * | 1993-07-21 | 1995-03-07 | Respironics, Inc. | Physiological monitoring system |
US5600548A (en) * | 1994-08-11 | 1997-02-04 | Sundstrand Corporation | DC content control for an inverter |
US5705189A (en) * | 1994-08-31 | 1998-01-06 | Roehm Gmbh Chemische Fabrik | Thermoplastic material for drug coatings which dissolve in intestinal juices |
US5862803A (en) * | 1993-09-04 | 1999-01-26 | Besson; Marcus | Wireless medical diagnosis and monitoring equipment |
US5862808A (en) * | 1997-08-26 | 1999-01-26 | Cigar Savor Enterprises Llc | Cigar punch |
US5868136A (en) * | 1996-02-20 | 1999-02-09 | Axelgaard Manufacturing Co. Ltd. | Medical electrode |
US6038464A (en) * | 1998-02-09 | 2000-03-14 | Axelgaard Manufacturing Co., Ltd. | Medical electrode |
US6083248A (en) * | 1995-06-23 | 2000-07-04 | Medtronic, Inc. | World wide patient location and data telemetry system for implantable medical devices |
US6200265B1 (en) * | 1999-04-16 | 2001-03-13 | Medtronic, Inc. | Peripheral memory patch and access method for use with an implantable medical device |
US6342774B1 (en) * | 2001-03-27 | 2002-01-29 | Motorola, Inc. | Battery having user charge capacity control |
US20020026111A1 (en) * | 2000-08-28 | 2002-02-28 | Neil Ackerman | Methods of monitoring glucose levels in a subject and uses thereof |
US20020032385A1 (en) * | 1995-02-24 | 2002-03-14 | Raymond Stephen A. | Health monitoring system |
US6358202B1 (en) * | 1999-01-25 | 2002-03-19 | Sun Microsystems, Inc. | Network for implanted computer devices |
US20030028226A1 (en) * | 1998-06-19 | 2003-02-06 | Medtronic, Inc. | Medical management system integrated programming apparatus for communication with an implantable medical device |
US6526315B1 (en) * | 2000-03-17 | 2003-02-25 | Tanita Corporation | Portable bioelectrical impedance measuring instrument |
US6531026B1 (en) * | 1999-06-23 | 2003-03-11 | Sony Chemicals Corp. | Method for mounting electronic elements |
US6680923B1 (en) * | 2000-05-23 | 2004-01-20 | Calypso Wireless, Inc. | Communication system and method |
US20040034295A1 (en) * | 2000-09-26 | 2004-02-19 | Marcos Salganicoff | Method and apparatus for real-time estimation and control of physiological parameters |
US20040092296A1 (en) * | 2002-10-31 | 2004-05-13 | Tadashi Minotani | Transceiver capable of causing series resonance with parasitic capacitance |
US20040122315A1 (en) * | 2002-09-24 | 2004-06-24 | Krill Jerry A. | Ingestible medical payload carrying capsule with wireless communication |
US20040121292A1 (en) * | 2002-08-08 | 2004-06-24 | Chung Bobby Hsiang-Hua | Wireless data communication link embedded in simulated weapon systems |
US20040186365A1 (en) * | 2002-12-31 | 2004-09-23 | Therasense, Inc. | Continuous glucose monitoring system and methods of use |
US6839659B2 (en) * | 2000-06-16 | 2005-01-04 | Isis Innovation Limited | System and method for acquiring data |
US6842636B2 (en) * | 2002-09-27 | 2005-01-11 | Axelgaard Manufacturing Co., Ltd. | Medical electrode |
US6845272B1 (en) * | 1999-05-25 | 2005-01-18 | Medicotest A/S | Skin electrode |
US20050017841A1 (en) * | 2000-09-08 | 2005-01-27 | Matsushita Electric Works, Ltd. | Data transmission system using a human body as a signal transmission path |
US20050020887A1 (en) * | 2001-10-11 | 2005-01-27 | Jason Goldberg | Medical monitoring device and system |
US20050021370A1 (en) * | 2000-08-29 | 2005-01-27 | Medtronic, Inc. | Medical device systems implemented network scheme for remote patient management |
US20050021103A1 (en) * | 1998-08-05 | 2005-01-27 | Dilorenzo Daniel John | Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease |
US20050027205A1 (en) * | 2001-12-14 | 2005-02-03 | Lionel Tarassenko | Combining measurements from breathing rate sensors |
US20050024198A1 (en) * | 1999-07-20 | 2005-02-03 | Ward William H. | Impedance matching network and multidimensional electromagnetic field coil for a transponder interrogator |
US20050043894A1 (en) * | 2003-08-22 | 2005-02-24 | Fernandez Dennis S. | Integrated biosensor and simulation system for diagnosis and therapy |
US20050062644A1 (en) * | 2003-09-08 | 2005-03-24 | Leci Jonathan Ilan | Capsule device to identify the location of an individual |
US20050065407A1 (en) * | 2003-09-18 | 2005-03-24 | Olympus Corporation | Energy supplying coil and capsule endoscope system |
US20050070778A1 (en) * | 2003-08-20 | 2005-03-31 | Lackey Robert P. | Hydration monitoring |
US20050192489A1 (en) * | 2000-11-08 | 2005-09-01 | Marshall Daniel R. | Swallowable data recorder capsule medical device |
US6987965B2 (en) * | 2000-04-18 | 2006-01-17 | Motorola, Inc. | Programmable wireless electrode system for medical monitoring |
US6990082B1 (en) * | 1999-11-08 | 2006-01-24 | Intel Corporation | Wireless apparatus having a transceiver equipped to support multiple wireless communication protocols |
US20060030760A1 (en) * | 2004-07-20 | 2006-02-09 | Geiger Mark A | Vital signs monitoring system with wireless pupilometer interface |
US20060028727A1 (en) * | 2002-08-20 | 2006-02-09 | Moon John A | Method and apparatus for drug product tracking using encoded optical identification elements |
US20060036134A1 (en) * | 2002-09-18 | 2006-02-16 | E-San Limited | Telemedicine system |
US7004395B2 (en) * | 1990-05-25 | 2006-02-28 | Broadcom Corporation | Multi-level hierarchical radio-frequency communication system |
US7009946B1 (en) * | 2000-06-22 | 2006-03-07 | Intel Corporation | Method and apparatus for multi-access wireless communication |
US7013162B2 (en) * | 1999-09-21 | 2006-03-14 | Ipr Licensing, Inc. | Dual mode unit for short range, high rate and long range, lower rate data communications |
US20060058602A1 (en) * | 2004-08-17 | 2006-03-16 | Kwiatkowski Krzysztof C | Interstitial fluid analyzer |
US7016648B2 (en) * | 2001-12-18 | 2006-03-21 | Ixi Mobile (Israel) Ltd. | Method, system and computer readable medium for downloading a software component to a device in a short distance wireless network |
US7020508B2 (en) * | 2002-08-22 | 2006-03-28 | Bodymedia, Inc. | Apparatus for detecting human physiological and contextual information |
US20060068006A1 (en) * | 1999-08-05 | 2006-03-30 | Dimensional Foods Corporation | Edible holographic products, particularly pharmaceuticals and methods and apparatus for producing same |
US20060164213A1 (en) * | 2005-01-26 | 2006-07-27 | Battelle Memorial Institute | Method for autonomous establishment and utilization of an active-RF tag network |
US20060183993A1 (en) * | 2004-12-30 | 2006-08-17 | Eli Horn | Device, system, and method for locating an in-vivo signal source |
US20060229053A1 (en) * | 2005-04-06 | 2006-10-12 | Zarlink Semiconductor Ab | Implantable RF telemetry devices with power saving mode |
US20070002038A1 (en) * | 2004-04-07 | 2007-01-04 | Olympus Corporation | Intra-subject position display system |
US7161484B2 (en) * | 2001-04-17 | 2007-01-09 | Micrel Medical Devices S.A. | System for monitoring medical parameters |
US7160258B2 (en) * | 2001-06-26 | 2007-01-09 | Entrack, Inc. | Capsule and method for treating or diagnosing the intestinal tract |
US20070006636A1 (en) * | 2003-04-11 | 2007-01-11 | Oxford Biosignals Limited | Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components |
US7164942B2 (en) * | 1998-11-09 | 2007-01-16 | Transpharma Medical Ltd. | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
US20070016089A1 (en) * | 2005-07-15 | 2007-01-18 | Fischell David R | Implantable device for vital signs monitoring |
US7171259B2 (en) * | 2003-04-17 | 2007-01-30 | Polar Electro Oy | Method and device for measuring heart rate, and method for manufacturing the device |
US7171177B2 (en) * | 2004-09-07 | 2007-01-30 | Electronics And Telecommunications Research Institute | Communication apparatus and method using human body as medium |
US20070027388A1 (en) * | 2005-08-01 | 2007-02-01 | Chang-An Chou | Patch-type physiological monitoring apparatus, system and network |
US20070027386A1 (en) * | 2003-07-16 | 2007-02-01 | Koninklijke Philips Electronics N.V. | Portable electronic device and a health management system arranged for monitoring a physiological condition of an individual |
US7176784B2 (en) * | 2004-01-21 | 2007-02-13 | Battelle Memorial Institute K1-53 | Multi-mode radio frequency device |
US20070038054A1 (en) * | 2004-05-20 | 2007-02-15 | Peter Zhou | Embedded bio-sensor system |
US20070049339A1 (en) * | 2005-08-29 | 2007-03-01 | Amit Barak | Method and apparatus of multiple entity wireless communication adapter |
US20070060797A1 (en) * | 2005-08-31 | 2007-03-15 | Ball James J | Automatic parameter status on an implantable medical device system |
US20070060800A1 (en) * | 2001-06-29 | 2007-03-15 | Darrel Drinan | Gateway platform for biological monitoring and delivery of therapeutic compounds |
US20070123772A1 (en) * | 2005-07-20 | 2007-05-31 | Neil Euliano | Medication compliance system and associated methods |
US20080014866A1 (en) * | 2006-07-12 | 2008-01-17 | Lipowski Joseph T | Transceiver architecture and method for wireless base-stations |
US20080021521A1 (en) * | 2006-07-18 | 2008-01-24 | Cardiac Pacemakers, Inc. | Implantable Medical Device Communication System |
US20080021519A1 (en) * | 2004-05-28 | 2008-01-24 | Jan De Geest | Communication Unit for a Person's Skin |
US20080027679A1 (en) * | 2004-07-21 | 2008-01-31 | Dror Shklarski | Wearable Device, System and Method for Measuring Physiological and/or Environmental Parameters |
US20080046038A1 (en) * | 2006-06-26 | 2008-02-21 | Hill Gerard J | Local communications network for distributed sensing and therapy in biomedical applications |
US20080045843A1 (en) * | 2004-08-12 | 2008-02-21 | Tomoharu Tsuji | Via-Human-Body Information Transmission System and Transmitter-Receiver |
US7336929B2 (en) * | 2004-07-05 | 2008-02-26 | Sony Ericsson Mobile Communications Japan, Inc. | Short range wireless communication system, portable terminal apparatus, and wireless communication apparatus |
US20080051667A1 (en) * | 2004-05-16 | 2008-02-28 | Rami Goldreich | Method And Device For Measuring Physiological Parameters At The Hand |
US20080051647A1 (en) * | 2006-05-11 | 2008-02-28 | Changwang Wu | Non-invasive acquisition of large nerve action potentials (NAPs) with closely spaced surface electrodes and reduced stimulus artifacts |
US7382247B2 (en) * | 2003-03-21 | 2008-06-03 | Welch Allyn, Inc. | Personal status physiologic monitor system and architecture and related monitoring methods |
US20080316020A1 (en) * | 2007-05-24 | 2008-12-25 | Robertson Timothy L | Rfid antenna for in-body device |
US20090009330A1 (en) * | 2007-07-03 | 2009-01-08 | Isao Sakama | Rfid tag mounting circuit board |
US20090016102A1 (en) * | 1996-05-01 | 2009-01-15 | Yusuke Jyouno | Nonvolatile semiconductor memory device which stores multi-value information |
US20090024045A1 (en) * | 2007-07-19 | 2009-01-22 | Rajan Prakash | Mechanical function marker channel for cardiac monitoring and therapy control |
US20090030297A1 (en) * | 2002-09-27 | 2009-01-29 | Medtronic Minimed, Inc. | Implantable sensor method and system |
US20090034209A1 (en) * | 2007-08-03 | 2009-02-05 | Samsung Electronics Co., Ltd. | Multi-module combination type portable electronic device |
US20090043171A1 (en) * | 2007-07-16 | 2009-02-12 | Peter Rule | Systems And Methods For Determining Physiological Parameters Using Measured Analyte Values |
US20090048498A1 (en) * | 2007-08-17 | 2009-02-19 | Frank Riskey | System and method of monitoring an animal |
US20100001841A1 (en) * | 2008-07-07 | 2010-01-07 | Cardullo Mario W | Dynamically distributable nano rfid device and related method |
US7647112B2 (en) * | 2004-02-11 | 2010-01-12 | Ethicon, Inc. | System and method for selectively stimulating different body parts |
US7647185B2 (en) * | 2000-06-16 | 2010-01-12 | Oxford Biosignals Limited | Combining measurements from different sensors |
US20100010330A1 (en) * | 2007-06-01 | 2010-01-14 | Medtronic Minimed, Inc. | Wireless monitor for a personal medical device system |
US7653031B2 (en) * | 2003-03-05 | 2010-01-26 | Timothy Gordon Godfrey | Advance notification of transmit opportunities on a shared-communications channel |
US20100027411A1 (en) * | 2005-10-26 | 2010-02-04 | Thomson Licensing | System and Method for Compensating for a Satellite Gateway Failure |
US7668437B1 (en) * | 1999-09-30 | 2010-02-23 | Sony Corporation | Recording apparatus, recording method, and record medium |
US20100049004A1 (en) * | 2008-04-21 | 2010-02-25 | Philometron, Inc. | Metabolic energy monitoring system |
US20100049006A1 (en) * | 2006-02-24 | 2010-02-25 | Surendar Magar | Medical signal processing system with distributed wireless sensors |
US20100049069A1 (en) * | 2006-12-01 | 2010-02-25 | Oxford Biosignals Limited | Biomedical signal morphology analysis method |
US20100049012A1 (en) * | 2006-11-21 | 2010-02-25 | Koninklijke Philips Electronics N.V. | Ingestible electronic capsule and in vivo drug delivery or diagnostic system |
Family Cites Families (330)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3679480A (en) | 1969-05-08 | 1972-07-25 | Dow Chemical Co | Electrical cell assembly |
US3944064A (en) | 1973-10-26 | 1976-03-16 | Alza Corporation | Self-monitored device for releasing agent at functional rate |
US4106348A (en) | 1974-02-20 | 1978-08-15 | U.S. Philips Corporation | Device for examination by means of ultrasonic vibrations |
US3893111A (en) | 1974-03-14 | 1975-07-01 | Albert Albert F | System and method for remote monitoring of animal temperature |
US4055178A (en) | 1976-03-10 | 1977-10-25 | Harrigan Roy Major | Drug delivery device for preventing contact of undissolved drug with the stomach lining |
DE2928477C3 (de) | 1979-07-14 | 1982-04-15 | Battelle-Institut E.V., 6000 Frankfurt | Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes |
US4331654A (en) | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
US4418697A (en) | 1981-08-17 | 1983-12-06 | Francine Tama | Electrode attachment method |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4564363A (en) | 1983-07-13 | 1986-01-14 | Smithkline Beckman Corporation | Delayed action assembly |
GB8322007D0 (en) | 1983-08-16 | 1983-09-21 | Wellcome Found | Pharmaceutical delivery system |
GB8422876D0 (en) | 1984-09-11 | 1984-10-17 | Secr Defence | Silicon implant devices |
FR2571603B1 (fr) | 1984-10-11 | 1989-01-06 | Ascher Gilles | Enregistreur portatif d'electrocardiogrammes |
US4654165A (en) | 1985-04-16 | 1987-03-31 | Micro Tracers, Inc. | Microingredient containing tracer |
US4725997A (en) | 1986-08-22 | 1988-02-16 | Aprex Corporation | Contingent dosing device |
US4784162A (en) | 1986-09-23 | 1988-11-15 | Advanced Medical Technologies | Portable, multi-channel, physiological data monitoring system |
US4896261A (en) | 1986-11-24 | 1990-01-23 | Motorola Inc. | System for scheduling serial message transmission on a bus which is adoptable for rescheduling prioritized messages using a doubly-linked list |
US4876093A (en) | 1987-07-02 | 1989-10-24 | Alza Corporation | Dispenser with dispersing member for delivering beneficial agent |
DE3723310A1 (de) | 1987-07-15 | 1989-01-26 | John Urquhart | Pharmazeutisches praeparat und verfahren zu seiner herstellung |
US5002772A (en) | 1988-05-31 | 1991-03-26 | Pfizer Inc. | Gastric retention system for controlled drug release |
US4975230A (en) | 1988-06-17 | 1990-12-04 | Vapor Technologies Inc. | Method of making an open pore structure |
WO1991003184A1 (de) | 1989-08-29 | 1991-03-21 | William Prym-Werke Gmbh & Co. Kg | Knopfverschluss, insbesondere für kleidungsstücke |
US4987897A (en) | 1989-09-18 | 1991-01-29 | Medtronic, Inc. | Body bus medical device communication system |
US5395366A (en) | 1991-05-30 | 1995-03-07 | The State University Of New York | Sampling capsule and process |
US6605046B1 (en) | 1991-06-03 | 2003-08-12 | Del Mar Medical Systems, Llc | Ambulatory physio-kinetic monitor with envelope enclosure |
US5176626A (en) | 1992-01-15 | 1993-01-05 | Wilson-Cook Medical, Inc. | Indwelling stent |
JPH05228128A (ja) | 1992-02-25 | 1993-09-07 | Olympus Optical Co Ltd | 医療用カプセル |
US5283136A (en) | 1992-06-03 | 1994-02-01 | Ramot University Authority For Applied Research And Industrial Development Ltd. | Rechargeable batteries |
US5318557A (en) | 1992-07-13 | 1994-06-07 | Elan Medical Technologies Limited | Medication administering device |
JP3454525B2 (ja) | 1992-07-23 | 2003-10-06 | 三洋電機株式会社 | マイクロマシンおよびマイクロマシンにおける電力システム |
US7758503B2 (en) | 1997-01-27 | 2010-07-20 | Lynn Lawrence A | Microprocessor system for the analysis of physiologic and financial datasets |
US5757326A (en) | 1993-03-29 | 1998-05-26 | Seiko Epson Corporation | Slot antenna device and wireless apparatus employing the antenna device |
CN1094275C (zh) | 1994-03-11 | 2002-11-13 | Ntt移动通信网株式会社 | 时间分集通信系统 |
IE70735B1 (en) | 1994-08-15 | 1996-12-11 | Elan Med Tech | Orally administrable delivery device |
US5485841A (en) | 1995-02-14 | 1996-01-23 | Univ Mcgill | Ultrasonic lung tissue assessment |
US5845265A (en) | 1995-04-26 | 1998-12-01 | Mercexchange, L.L.C. | Consignment nodes |
US5720771A (en) | 1995-08-02 | 1998-02-24 | Pacesetter, Inc. | Method and apparatus for monitoring physiological data from an implantable medical device |
USD377983S (en) | 1995-09-13 | 1997-02-11 | Mohamed Sabri | Cardiac monitor |
US5596302A (en) | 1996-01-17 | 1997-01-21 | Lucent Technologies Inc. | Ring oscillator using even numbers of differential stages with current mirrors |
US5833603A (en) | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
EA001070B1 (ru) | 1996-04-01 | 2000-10-30 | Валерий Иванович КОБОЗЕВ | Электростимулятор желудочно-кишечного тракта |
GB9608268D0 (en) | 1996-04-22 | 1996-06-26 | Robertson James L | Blister pack |
US5864578A (en) | 1996-04-29 | 1999-01-26 | Golden Bridge Technology, Inc. | Matched filter-based handoff method and apparatus |
JPH09330159A (ja) | 1996-06-11 | 1997-12-22 | Omron Corp | データ処理装置、ゲーム制御装置、データ処理方法、およびゲーム制御方法 |
US5792048A (en) | 1996-09-03 | 1998-08-11 | Schaefer; Guenter | Indentification pill with integrated microchip: smartpill, smartpill with integrated microchip and microprocessor for medical analyses and a smartpill, smartbox, smartplague, smartbadge or smartplate for luggage control on commercial airliners |
US6394953B1 (en) | 2000-02-25 | 2002-05-28 | Aspect Medical Systems, Inc. | Electrode array system for measuring electrophysiological signals |
US5963132A (en) | 1996-10-11 | 1999-10-05 | Avid Indentification Systems, Inc. | Encapsulated implantable transponder |
US8734339B2 (en) | 1996-12-16 | 2014-05-27 | Ip Holdings, Inc. | Electronic skin patch for real time monitoring of cardiac activity and personal health management |
US5928142A (en) | 1996-12-17 | 1999-07-27 | Ndm, Inc. | Biomedical electrode having a disposable electrode and a reusable leadwire adapter that interfaces with a standard leadwire connector |
US6122351A (en) | 1997-01-21 | 2000-09-19 | Med Graph, Inc. | Method and system aiding medical diagnosis and treatment |
US5921925A (en) | 1997-05-30 | 1999-07-13 | Ndm, Inc. | Biomedical electrode having a disposable electrode and a reusable leadwire adapter that interfaces with a standard leadwire connector |
US6409674B1 (en) | 1998-09-24 | 2002-06-25 | Data Sciences International, Inc. | Implantable sensor with wireless communication |
US5948227A (en) | 1997-12-17 | 1999-09-07 | Caliper Technologies Corp. | Methods and systems for performing electrophoretic molecular separations |
GB9801363D0 (en) | 1998-01-22 | 1998-03-18 | Danbiosyst Uk | Novel dosage form |
US6097927A (en) | 1998-01-27 | 2000-08-01 | Symbix, Incorporated | Active symbolic self design method and apparatus |
US6275476B1 (en) | 1998-02-19 | 2001-08-14 | Micron Technology, Inc. | Method of addressing messages and communications system |
US6141592A (en) | 1998-03-06 | 2000-10-31 | Intermedics Inc. | Data transmission using a varying electric field |
CA2332112C (en) | 1998-05-13 | 2004-02-10 | Cygnus, Inc. | Monitoring of physiological analytes |
TW406018B (en) | 1998-05-21 | 2000-09-21 | Elan Corp Plc | Improved adhesive system for medical devices |
US6704602B2 (en) | 1998-07-02 | 2004-03-09 | Medtronic, Inc. | Implanted medical device/external medical instrument communication utilizing surface electrodes |
US6558320B1 (en) | 2000-01-20 | 2003-05-06 | Medtronic Minimed, Inc. | Handheld personal data assistant (PDA) with a medical device and method of using the same |
CA2341708A1 (en) | 1998-09-04 | 2000-03-16 | Wolfe Research Pty. Ltd. | Medical implant system |
CA2343404C (en) | 1998-09-11 | 2002-11-12 | Key-Trak, Inc. | Object tracking system with non-contact object detection and identification |
DE19983480T1 (de) | 1998-09-18 | 2001-11-29 | Hitachi Maxell | Halbleitervorrichtung zur kontaktlosen Kommunikation |
US6217744B1 (en) | 1998-12-18 | 2001-04-17 | Peter Crosby | Devices for testing fluid |
US6117077A (en) | 1999-01-22 | 2000-09-12 | Del Mar Medical Systems, Llc | Long-term, ambulatory physiological recorder |
US8636648B2 (en) | 1999-03-01 | 2014-01-28 | West View Research, Llc | Endoscopic smart probe |
US6285897B1 (en) | 1999-04-07 | 2001-09-04 | Endonetics, Inc. | Remote physiological monitoring system |
US6366206B1 (en) | 1999-06-02 | 2002-04-02 | Ball Semiconductor, Inc. | Method and apparatus for attaching tags to medical and non-medical devices |
DE19929328A1 (de) | 1999-06-26 | 2001-01-04 | Daimlerchrysler Aerospace Ag | Vorrichtung zur medizinischen Langzeitüberwachung von Personen |
US6206702B1 (en) | 1999-08-24 | 2001-03-27 | Deborah A. Hayden | Methods and devices for treating unilateral neglect |
US6533733B1 (en) * | 1999-09-24 | 2003-03-18 | Ut-Battelle, Llc | Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring |
US6426863B1 (en) | 1999-11-25 | 2002-07-30 | Lithium Power Technologies, Inc. | Electrochemical capacitor |
GB9930000D0 (en) | 1999-12-21 | 2000-02-09 | Phaeton Research Ltd | An ingestible device |
WO2001045793A1 (en) * | 1999-12-21 | 2001-06-28 | Medtronic, Inc. | System for dynamic remote networking with implantable medical devices |
US6294999B1 (en) | 1999-12-29 | 2001-09-25 | Becton, Dickinson And Company | Systems and methods for monitoring patient compliance with medication regimens |
US7039453B2 (en) | 2000-02-08 | 2006-05-02 | Tarun Mullick | Miniature ingestible capsule |
US7177675B2 (en) | 2000-02-09 | 2007-02-13 | Cns Response, Inc | Electroencephalography based systems and methods for selecting therapies and predicting outcomes |
EP1693000B1 (en) | 2000-03-08 | 2013-05-08 | Given Imaging Ltd. | A device for in vivo imaging |
US6654638B1 (en) | 2000-04-06 | 2003-11-25 | Cardiac Pacemakers, Inc. | Ultrasonically activated electrodes |
US6432292B1 (en) | 2000-05-16 | 2002-08-13 | Metallic Power, Inc. | Method of electrodepositing metal on electrically conducting particles |
IL163684A0 (en) | 2000-05-31 | 2005-12-18 | Given Imaging Ltd | Measurement of electrical characteristics of tissue |
US6961285B2 (en) | 2000-07-07 | 2005-11-01 | Ddms Holdings L.L.C. | Drug delivery management system |
JP4428835B2 (ja) | 2000-08-09 | 2010-03-10 | 昭和電工株式会社 | 磁気記録媒体及びその製造方法 |
US8036731B2 (en) | 2001-01-22 | 2011-10-11 | Spectrum Dynamics Llc | Ingestible pill for diagnosing a gastrointestinal tract |
KR20020015907A (ko) | 2000-08-23 | 2002-03-02 | 정병렬 | 심장박동수에 따른 게임제어를 통한 체력증진방법 및 그시스템 |
US6720923B1 (en) | 2000-09-14 | 2004-04-13 | Stata Labs, Llc | Antenna design utilizing a cavity architecture for global positioning system (GPS) applications |
US7024248B2 (en) | 2000-10-16 | 2006-04-04 | Remon Medical Technologies Ltd | Systems and methods for communicating with implantable devices |
US6929636B1 (en) | 2000-11-08 | 2005-08-16 | Hewlett-Packard Development Company, L.P. | Internal drug dispenser capsule medical device |
US6689117B2 (en) | 2000-12-18 | 2004-02-10 | Cardiac Pacemakers, Inc. | Drug delivery system for implantable medical device |
KR100526699B1 (ko) | 2001-01-17 | 2005-11-08 | 이종식 | 네트워크 게임방법 및 그 시스템 |
JP2002224053A (ja) | 2001-02-05 | 2002-08-13 | Next:Kk | 遠隔医療管理システム |
JP2002263185A (ja) | 2001-03-12 | 2002-09-17 | Sanyo Electric Co Ltd | 投薬システム及び方法及び投薬装置 |
JP2002290212A (ja) | 2001-03-27 | 2002-10-04 | Nec Corp | 電圧制御発振器 |
JP2002291684A (ja) | 2001-03-29 | 2002-10-08 | Olympus Optical Co Ltd | 外科手術用内視鏡及び外套管 |
US6694161B2 (en) | 2001-04-20 | 2004-02-17 | Monsanto Technology Llc | Apparatus and method for monitoring rumen pH |
US6782290B2 (en) | 2001-04-27 | 2004-08-24 | Medtronic, Inc. | Implantable medical device with rechargeable thin-film microbattery power source |
AU2002304269A1 (en) | 2001-05-20 | 2002-12-03 | Given Imaging Ltd. | A floatable in vivo sensing device |
AU2002311613A1 (en) | 2001-06-18 | 2003-01-02 | Given Imaging Ltd. | In vivo sensing device with a circuit board having rigid sections and flexible sections |
US20030017826A1 (en) | 2001-07-17 | 2003-01-23 | Dan Fishman | Short-range wireless architecture |
US6951536B2 (en) | 2001-07-30 | 2005-10-04 | Olympus Corporation | Capsule-type medical device and medical system |
US6650191B2 (en) | 2001-09-07 | 2003-11-18 | Texas Instruments Incorporated | Low jitter ring oscillator architecture |
US6604650B2 (en) | 2001-09-28 | 2003-08-12 | Koninklijke Philips Electronics N.V. | Bottle-cap medication reminder and overdose safeguard |
US20050137480A1 (en) | 2001-10-01 | 2005-06-23 | Eckhard Alt | Remote control of implantable device through medical implant communication service band |
US20030152622A1 (en) | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
US7377647B2 (en) | 2001-11-13 | 2008-05-27 | Philadelphia Retina Endowment Fund | Clarifying an image of an object to perform a procedure on the object |
US7877273B2 (en) | 2002-01-08 | 2011-01-25 | Fredric David Abramson | System and method for evaluating and providing nutrigenomic data, information and advice |
EP1464026A2 (en) | 2002-01-11 | 2004-10-06 | Hexalog SA | Systems and methods for medication monitoring |
US6958034B2 (en) | 2002-02-11 | 2005-10-25 | Given Imaging Ltd. | Self propelled device |
US6935560B2 (en) | 2002-02-26 | 2005-08-30 | Safety Syringes, Inc. | Systems and methods for tracking pharmaceuticals within a facility |
US20030162556A1 (en) | 2002-02-28 | 2003-08-28 | Libes Michael A. | Method and system for communication between two wireless-enabled devices |
US7468032B2 (en) | 2002-12-18 | 2008-12-23 | Cardiac Pacemakers, Inc. | Advanced patient management for identifying, displaying and assisting with correlating health-related data |
JP4363843B2 (ja) * | 2002-03-08 | 2009-11-11 | オリンパス株式会社 | カプセル型内視鏡 |
US7022070B2 (en) | 2002-03-22 | 2006-04-04 | Mini-Mitter Co., Inc. | Method for continuous monitoring of patients to detect the potential onset of sepsis |
JP3869291B2 (ja) | 2002-03-25 | 2007-01-17 | オリンパス株式会社 | カプセル型医療装置 |
US7654901B2 (en) | 2002-04-10 | 2010-02-02 | Breving Joel S | Video game system using bio-feedback devices |
US20030216622A1 (en) | 2002-04-25 | 2003-11-20 | Gavriel Meron | Device and method for orienting a device in vivo |
TW553735B (en) | 2002-05-01 | 2003-09-21 | Jin-Shing Luo | Common electrode using human body as common electric reservoir and application thereof |
JP2003325439A (ja) | 2002-05-15 | 2003-11-18 | Olympus Optical Co Ltd | カプセル型医療装置 |
JP2004041709A (ja) | 2002-05-16 | 2004-02-12 | Olympus Corp | カプセル医療装置 |
US6847844B2 (en) | 2002-06-06 | 2005-01-25 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of data communication with implanted device and associated apparatus |
US20040008123A1 (en) | 2002-07-15 | 2004-01-15 | Battelle Memorial Institute | System and method for tracking medical devices |
US20040019172A1 (en) | 2002-07-26 | 2004-01-29 | Tou-Hsiung Yang | Biodegradable, water absorbable resin and its preparation method |
US7211349B2 (en) | 2002-08-06 | 2007-05-01 | Wilson Greatbatch Technologies, Inc. | Silver vanadium oxide provided with a metal oxide coating |
US20040049245A1 (en) | 2002-09-09 | 2004-03-11 | Volker Gass | Autonomous patch for communication with an implantable device, and medical kit for using said patch |
US20040073454A1 (en) | 2002-10-10 | 2004-04-15 | John Urquhart | System and method of portal-mediated, website-based analysis of medication dosing |
US20050272989A1 (en) | 2004-06-04 | 2005-12-08 | Medtronic Minimed, Inc. | Analyte sensors and methods for making and using them |
US6959217B2 (en) | 2002-10-24 | 2005-10-25 | Alfred E. Mann Foundation For Scientific Research | Multi-mode crystal oscillator system selectively configurable to minimize power consumption or noise generation |
US7232627B2 (en) | 2002-11-08 | 2007-06-19 | Honda Motor Co., Ltd. | Electrode for solid polymer fuel cell |
AU2003302020B2 (en) * | 2002-11-14 | 2008-01-31 | Ethicon Endo-Surgery, Inc. | Methods and devices for detecting tissue cells |
WO2004049947A2 (en) | 2002-11-29 | 2004-06-17 | Given Imaging Ltd. | Methods device and system for in vivo diagnosis |
NZ539915A (en) | 2002-12-11 | 2007-09-28 | Pfizer Prod Inc | Controlled-release of an active substance into a high fat environment |
EP1578260B1 (en) | 2002-12-16 | 2012-10-24 | Given Imaging Ltd. | Device, system and method for selective activation of in vivo sensors |
US7505029B2 (en) | 2002-12-31 | 2009-03-17 | Intel Corporation | System and method for controlling multiple processing units with a single input device |
US6975174B1 (en) | 2002-12-31 | 2005-12-13 | Radioframe Networks, Inc. | Clock oscillator |
KR100873683B1 (ko) | 2003-01-25 | 2008-12-12 | 한국과학기술연구원 | 인체통신방법, 인체통신시스템 및 이에 사용되는 캡슐형 내시경 |
US20040267240A1 (en) | 2003-01-29 | 2004-12-30 | Yossi Gross | Active drug delivery in the gastrointestinal tract |
WO2004066903A2 (en) | 2003-01-29 | 2004-08-12 | E-Pill Pharma Ltd. | Active drug delivery in the gastrointestinal tract |
US7002476B2 (en) | 2003-01-30 | 2006-02-21 | Leap Of Faith Technologies, Inc. | Medication compliance system |
JP4158097B2 (ja) | 2003-02-27 | 2008-10-01 | ソニー株式会社 | 認証システム |
US7245954B2 (en) | 2003-03-27 | 2007-07-17 | Given Imaging Ltd. | Measuring a gradient in-vivo |
US20040193446A1 (en) | 2003-03-27 | 2004-09-30 | Mayer Steven Lloyd | System and method for managing a patient treatment program including a prescribed drug regimen |
GB0308114D0 (en) | 2003-04-08 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
US7972616B2 (en) | 2003-04-17 | 2011-07-05 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
JP4414682B2 (ja) | 2003-06-06 | 2010-02-10 | オリンパス株式会社 | 超音波内視鏡装置 |
US7252152B2 (en) | 2003-06-18 | 2007-08-07 | Weatherford/Lamb, Inc. | Methods and apparatus for actuating a downhole tool |
EP2263513B1 (en) | 2003-06-24 | 2013-08-07 | Olympus Corporation | Capsule type medical device communication system, capsule type medical device, and biological information reception device |
WO2005007223A2 (en) | 2003-07-16 | 2005-01-27 | Sasha John | Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations |
JP4038575B2 (ja) | 2003-07-25 | 2008-01-30 | 独立行政法人産業技術総合研究所 | バイオセンサ、バイオセンサ装置またはバイオセンサの保存方法 |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US20050055014A1 (en) | 2003-08-04 | 2005-03-10 | Coppeta Jonathan R. | Methods for accelerated release of material from a reservoir device |
EP1670547B1 (en) | 2003-08-18 | 2008-11-12 | Cardiac Pacemakers, Inc. | Patient monitoring system |
US20050172958A1 (en) | 2003-08-20 | 2005-08-11 | The Brigham And Women's Hospital, Inc. | Inhalation device and system for the remote monitoring of drug administration |
JP4398204B2 (ja) | 2003-08-29 | 2010-01-13 | オリンパス株式会社 | 被検体内導入装置および無線型被検体内情報取得システム |
JP3993546B2 (ja) | 2003-09-08 | 2007-10-17 | オリンパス株式会社 | 被検体内導入装置および無線型被検体内情報取得システム |
KR101084554B1 (ko) | 2003-09-12 | 2011-11-17 | 보디미디어 인코퍼레이티드 | 심장 관련 파라미터를 측정하기 위한 방법 및 장치 |
US20050075145A1 (en) | 2003-10-03 | 2005-04-07 | Dvorak Joseph L. | Method and system for coordinating use of objects using wireless communications |
US20050096514A1 (en) | 2003-11-01 | 2005-05-05 | Medtronic, Inc. | Gastric activity notification |
US6892590B1 (en) | 2003-11-04 | 2005-05-17 | Andermotion Technologies Llc | Single-balanced shield electrode configuration for use in capacitive displacement sensing systems and methods |
US7101343B2 (en) | 2003-11-05 | 2006-09-05 | Temple University Of The Commonwealth System Of Higher Education | Implantable telemetric monitoring system, apparatus, and method |
JP2005158770A (ja) | 2003-11-20 | 2005-06-16 | Matsushita Electric Ind Co Ltd | 積層基板とその製造方法及び前記積層基板を用いたモジュールの製造方法とその製造装置 |
US6987691B2 (en) | 2003-12-02 | 2006-01-17 | International Business Machines Corporation | Easy axis magnetic amplifier |
US7427266B2 (en) | 2003-12-15 | 2008-09-23 | Hewlett-Packard Development Company, L.P. | Method and apparatus for verification of ingestion |
JP2005185567A (ja) | 2003-12-25 | 2005-07-14 | Olympus Corp | 医療用カプセル装置 |
JP2005192821A (ja) | 2004-01-07 | 2005-07-21 | Olympus Corp | カプセル型医療装置 |
US7081807B2 (en) | 2004-01-14 | 2006-07-25 | Joseph Lai | Automatic pill reminder bottles |
US20060154642A1 (en) | 2004-02-20 | 2006-07-13 | Scannell Robert F Jr | Medication & health, environmental, and security monitoring, alert, intervention, information and network system with associated and supporting apparatuses |
US20050187789A1 (en) | 2004-02-25 | 2005-08-25 | Cardiac Pacemakers, Inc. | Advanced patient and medication therapy management system and method |
US7904133B2 (en) | 2004-02-27 | 2011-03-08 | Koninklijke Philips Electronics N.V. | Wearable wireless device for monitoring, analyzing and communicating physiological status |
US7406105B2 (en) | 2004-03-03 | 2008-07-29 | Alfred E. Mann Foundation For Scientific Research | System and method for sharing a common communication channel between multiple systems of implantable medical devices |
CA2564977C (en) | 2004-04-24 | 2014-08-12 | Inrange Systems, Inc. | Integrated, non-sequential, remote medication management and compliance system |
US20050245794A1 (en) | 2004-04-29 | 2005-11-03 | Medtronic, Inc. | Communication with implantable monitoring probe |
JP4445799B2 (ja) * | 2004-05-24 | 2010-04-07 | オリンパス株式会社 | 被検体内導入装置および医療装置 |
US7653542B2 (en) | 2004-05-26 | 2010-01-26 | Verizon Business Global Llc | Method and system for providing synthesized speech |
WO2005123185A1 (en) | 2004-06-10 | 2005-12-29 | Ndi Medical, Llc | Implantable system for processing myoelectric signals |
US7460014B2 (en) | 2004-06-22 | 2008-12-02 | Vubiq Incorporated | RFID system utilizing parametric reflective technology |
JP2006006377A (ja) | 2004-06-22 | 2006-01-12 | Elquest Corp | 薬剤包装用の薬包紙 |
US20060001496A1 (en) | 2004-07-02 | 2006-01-05 | Abrosimov Igor A | Array oscillator and polyphase clock generator |
US7317378B2 (en) | 2004-08-17 | 2008-01-08 | Tagent Corporation | Product identification tag device and reader |
US7253716B2 (en) | 2004-08-17 | 2007-08-07 | Tagent Corporation | Trackable pills with electronic ID tags |
US8518022B2 (en) | 2004-08-27 | 2013-08-27 | Medimetrics Personalized Drug Delivery, Inc. | Electronically and remotely controlled pill and system for delivering at least one medicament |
GB2418144A (en) | 2004-09-17 | 2006-03-22 | Psimedica Ltd | Medical device for delivery of beneficial substance |
US20060065713A1 (en) | 2004-09-24 | 2006-03-30 | John Russell Kingery | System and method for monitored administration of medical products to patients |
EP1812880A2 (en) | 2004-09-30 | 2007-08-01 | Koninklijke Philips Electronics N.V. | System for automatic continuous and reliable patient identification for association of wireless medical devices to patients |
US20060078765A1 (en) | 2004-10-12 | 2006-04-13 | Laixia Yang | Nano-structured ion-conducting inorganic membranes for fuel cell applications |
JP2008011865A (ja) | 2004-10-27 | 2008-01-24 | Sharp Corp | 健康管理装置及びこれを機能させるためのプログラム |
IL171772A (en) | 2004-11-04 | 2009-11-18 | Given Imaging Ltd | Device and method for selecting and integrating the absorption device |
US7414534B1 (en) | 2004-11-09 | 2008-08-19 | Pacesetter, Inc. | Method and apparatus for monitoring ingestion of medications using an implantable medical device |
US7930064B2 (en) | 2004-11-19 | 2011-04-19 | Parata Systems, Llc | Automated drug discrimination during dispensing |
JP2008521541A (ja) * | 2004-12-02 | 2008-06-26 | ギブン イメージング リミテッド | 生体内電気刺激のデバイス、システム、および方法 |
US8374693B2 (en) | 2004-12-03 | 2013-02-12 | Cardiac Pacemakers, Inc. | Systems and methods for timing-based communication between implantable medical devices |
US7616710B2 (en) | 2004-12-08 | 2009-11-10 | Electronics And Telecommunications Research Institute | Frequency offset estimating method and receiver employing the same |
US20060148254A1 (en) | 2005-01-05 | 2006-07-06 | Mclean George Y | Activated iridium oxide electrodes and methods for their fabrication |
US20080269664A1 (en) | 2005-01-18 | 2008-10-30 | Koninklijke Philips Electronics, N.V. | System and Method For Controlling Traversal of an Igested Capsule |
US20080194912A1 (en) | 2005-01-18 | 2008-08-14 | Koninklijke Philips Electronics, N.V. | Electronically Controlled Ingestible Capsule for Sampling Fluids in Alimentary Tract |
US7345588B2 (en) | 2005-01-28 | 2008-03-18 | Innotek, Inc. | Receiver collar |
JP4099484B2 (ja) | 2005-02-09 | 2008-06-11 | 株式会社カイザーテクノロジー | 通信システム。 |
JP4731936B2 (ja) | 2005-02-09 | 2011-07-27 | 本田技研工業株式会社 | 回転式可変抵抗器 |
WO2006085087A2 (en) | 2005-02-11 | 2006-08-17 | The University Court Of The University Of Glasgow | Sensing device, apparatus and system, and method for operating the same |
US7850645B2 (en) | 2005-02-11 | 2010-12-14 | Boston Scientific Scimed, Inc. | Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power |
KR20060097523A (ko) | 2005-03-10 | 2006-09-14 | 강성철 | 리드와이어의 자동 탈피 및 도금장치 |
US20060252999A1 (en) | 2005-05-03 | 2006-11-09 | Devaul Richard W | Method and system for wearable vital signs and physiology, activity, and environmental monitoring |
US20060216603A1 (en) | 2005-03-26 | 2006-09-28 | Enable Ipc | Lithium-ion rechargeable battery based on nanostructures |
JP2006278091A (ja) | 2005-03-29 | 2006-10-12 | Hitachi Maxell Ltd | コイン形酸化銀電池 |
US20060224326A1 (en) | 2005-03-31 | 2006-10-05 | St Ores John W | Integrated data collection and analysis for clinical study |
SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
US7414543B2 (en) | 2005-04-28 | 2008-08-19 | Honeywell International Inc. | Multiple miniature avionic displays |
US20060255064A1 (en) | 2005-05-10 | 2006-11-16 | Par Technologies, Llc | Fluid container with integrated valve |
ATE526952T1 (de) | 2005-05-20 | 2011-10-15 | Dow Global Technologies Llc | Überwachung der korrekten zufuhr oraler arzneimittel mittels radiofrequenzidentifikationsetiketten |
JP4254747B2 (ja) | 2005-05-31 | 2009-04-15 | カシオ計算機株式会社 | 光源装置及び投影装置 |
EP1904173B8 (en) | 2005-06-09 | 2016-06-08 | Medtronic, Inc. | Implantable medical device with electrodes on multiple housing surfaces |
WO2006130988A1 (en) | 2005-06-10 | 2006-12-14 | Telecommunications Research Laboratories | Wireless communication system |
US7782189B2 (en) | 2005-06-20 | 2010-08-24 | Carestream Health, Inc. | System to monitor the ingestion of medicines |
US7299034B2 (en) | 2005-06-21 | 2007-11-20 | Lawrence Kates | System and method for wearable electronics |
EP1909765A1 (en) | 2005-07-22 | 2008-04-16 | Dow Gloval Technologies Inc. | Oral drug compliance monitoring using sound detection |
WO2007021496A2 (en) | 2005-08-18 | 2007-02-22 | Walker Digital, Llc | Systems and methods for improved health care compliance |
WO2007028035A2 (en) | 2005-09-01 | 2007-03-08 | Proteus Biomedical, Inc. | Implantable zero-wire communications system |
JP2007068622A (ja) | 2005-09-05 | 2007-03-22 | Olympus Corp | 被検体内情報取得システム |
US7673679B2 (en) | 2005-09-19 | 2010-03-09 | Schlumberger Technology Corporation | Protective barriers for small devices |
GB0519837D0 (en) | 2005-09-29 | 2005-11-09 | Smartlife Technology Ltd | Knitting techniques |
GB0519836D0 (en) | 2005-09-29 | 2005-11-09 | Smartlife Technology Ltd | Contact sensors |
US7456329B2 (en) | 2005-11-30 | 2008-11-25 | Exxonmobil Chemical Patents Inc. | Polyolefins from non-conventional feeds |
EP1956973B1 (en) | 2005-11-30 | 2017-09-13 | Koninklijke Philips N.V. | Electro-mechanical connector for thin medical monitoring patch |
CN1991868B (zh) * | 2005-12-02 | 2013-02-06 | 株式会社半导体能源研究所 | 半导体装置 |
US8295932B2 (en) | 2005-12-05 | 2012-10-23 | Metacure Limited | Ingestible capsule for appetite regulation |
NL1030608C2 (nl) | 2005-12-06 | 2007-06-07 | Patrick Antonius Hendri Meeren | Blisterverpakking, samenstel van een blisterverpakking en een houder, alsmede werkwijze voor het verpakken van objecten. |
JP2007159631A (ja) | 2005-12-09 | 2007-06-28 | Taito Corp | ゲーム機及びゲームプログラム |
US20070135691A1 (en) | 2005-12-12 | 2007-06-14 | General Electric Company | Medicament compliance monitoring system, method, and medicament container |
CA2635313C (en) | 2005-12-29 | 2013-12-31 | Osmotica Corp. | Triple combination release multi-layered tablet |
TWI306023B (en) | 2005-12-30 | 2009-02-11 | Ind Tech Res Inst | Monitoring apparatus for physical movements of a body organ and method for acouiring the same |
JP5306824B2 (ja) | 2006-01-11 | 2013-10-02 | クゥアルコム・インコーポレイテッド | 無線端末のビーコン信号の使用を含むタイミングおよび/または同期に関連する方法および装置 |
CN100571239C (zh) * | 2006-01-16 | 2009-12-16 | 华为技术有限公司 | 通信系统中的同步导频序列生成系统和方法 |
WO2007092543A2 (en) | 2006-02-06 | 2007-08-16 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive cardiac monitor and methods of using continuously recorded cardiac data |
US8200320B2 (en) | 2006-03-03 | 2012-06-12 | PhysioWave, Inc. | Integrated physiologic monitoring systems and methods |
CA2645903A1 (en) | 2006-03-30 | 2007-10-11 | Dow Global Technologies Inc. | Method and system for monitoring and analyzing compliance with internal dosing regimen |
US7806852B1 (en) | 2006-04-03 | 2010-10-05 | Jurson Phillip A | Method and apparatus for patient-controlled medical therapeutics |
MY187399A (en) * | 2006-04-28 | 2021-09-22 | Qualcomm Inc | Method and apparatus for enhanced paging |
CN101496042A (zh) | 2006-05-02 | 2009-07-29 | 普罗秋斯生物医学公司 | 患者定制的治疗方案 |
JP5036808B2 (ja) * | 2006-05-10 | 2012-09-26 | インターデイジタル テクノロジー コーポレーション | 統合無線送信/受信ユニットにおけるバッテリ管理のための方法および装置 |
EP2029194A2 (en) | 2006-05-19 | 2009-03-04 | CVRX, Inc. | Characterization and modulation of physiologic response using baroreflex activation in conjunction with drug therapy |
FI120482B (fi) | 2006-06-08 | 2009-11-13 | Suunto Oy | Anturointijärjestely |
JP2009540932A (ja) | 2006-06-21 | 2009-11-26 | プロテウス バイオメディカル インコーポレイテッド | 陰極アーク製作構造物を備えるインプラント型医療デバイス |
CN101472640B (zh) | 2006-06-23 | 2012-12-12 | 皇家飞利浦电子股份有限公司 | 药物输送系统 |
DE502006003608D1 (de) | 2006-06-29 | 2009-06-10 | Edwin Kohl | Personalisierte Blisterpackung und Verfahren zur automatischen Verpackung einer individuell festgelegten Produktzusammenstellung |
US8165896B2 (en) | 2006-06-29 | 2012-04-24 | The Invention Science Fund I, Llc | Compliance data for health-related procedures |
IL176712A0 (en) | 2006-07-05 | 2007-10-31 | Michael Cohen Alloro | Medication dispenser |
JP5241714B2 (ja) | 2006-07-07 | 2013-07-17 | プロテウス デジタル ヘルス, インコーポレイテッド | スマートな非経口送達システム |
US20080020037A1 (en) | 2006-07-11 | 2008-01-24 | Robertson Timothy L | Acoustic Pharma-Informatics System |
EP2043728A2 (en) | 2006-07-11 | 2009-04-08 | Microchips, Inc. | Multi-reservoir pump device for dialysis, biosensing, or delivery of substances |
US8588887B2 (en) | 2006-09-06 | 2013-11-19 | Innurvation, Inc. | Ingestible low power sensor device and system for communicating with same |
EP2063785A4 (en) | 2006-09-06 | 2011-08-31 | Innurvation Inc | SYSTEM AND METHOD FOR EXCHANGE OF ACOUSTIC INFORMATION INVOLVING A LOW-POWERFUL CAPABLE OF INTEGRATION |
US20080077028A1 (en) | 2006-09-27 | 2008-03-27 | Biotronic Crm Patent | Personal health monitoring and care system |
JP5987151B2 (ja) | 2006-09-29 | 2016-09-07 | メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ | 小型閾値センサ |
US20080091089A1 (en) | 2006-10-12 | 2008-04-17 | Kenneth Shane Guillory | Single use, self-contained surface physiological monitor |
WO2008066617A2 (en) | 2006-10-17 | 2008-06-05 | Proteus Biomedical, Inc. | Low voltage oscillator for medical devices |
EP2083680B1 (en) | 2006-10-25 | 2016-08-10 | Proteus Digital Health, Inc. | Controlled activation ingestible identifier |
US8214007B2 (en) | 2006-11-01 | 2012-07-03 | Welch Allyn, Inc. | Body worn physiological sensor device having a disposable electrode module |
US8718193B2 (en) | 2006-11-20 | 2014-05-06 | Proteus Digital Health, Inc. | Active signal processing personal health signal receivers |
US8180425B2 (en) | 2006-12-05 | 2012-05-15 | Tyco Healthcare Group Lp | ECG lead wire organizer and dispenser |
CN101547635B (zh) | 2006-12-07 | 2011-09-14 | 皇家飞利浦电子股份有限公司 | 手持式、可重新定位ecg探测器 |
ES2930588T3 (es) | 2007-02-01 | 2022-12-19 | Otsuka Pharma Co Ltd | Sistemas de marcador de eventos ingeribles |
KR101528748B1 (ko) | 2007-02-14 | 2015-06-15 | 프로테우스 디지털 헬스, 인코포레이티드 | 고 표면적 전극을 갖는 체내 전원 |
EP2124725A1 (en) | 2007-03-09 | 2009-12-02 | Proteus Biomedical, Inc. | In-body device having a multi-directional transmitter |
US9270025B2 (en) | 2007-03-09 | 2016-02-23 | Proteus Digital Health, Inc. | In-body device having deployable antenna |
WO2008115722A1 (en) | 2007-03-16 | 2008-09-25 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Security for blister packs |
WO2008120128A2 (en) | 2007-03-30 | 2008-10-09 | Koninklijke Philips Electronics N.V. | System and method for pill communication and control |
US7946101B1 (en) | 2007-05-30 | 2011-05-24 | Walgreen Co. | Method and system for verification of contents of a multi-cell, multi-product blister pack |
GB2450517A (en) | 2007-06-27 | 2008-12-31 | Smartlife Technology Ltd | Electrical resistance of yarn or fabric changes with temperature |
CN201076456Y (zh) | 2007-06-29 | 2008-06-25 | 洪金叶 | 夹挂式无线传输心跳侦测装置 |
US20090009332A1 (en) | 2007-07-03 | 2009-01-08 | Endotronix, Inc. | System and method for monitoring ingested medication via rf wireless telemetry |
JP4520491B2 (ja) | 2007-07-09 | 2010-08-04 | オリンパス株式会社 | カプセル型医療システム |
US20090062670A1 (en) | 2007-08-30 | 2009-03-05 | Gary James Sterling | Heart monitoring body patch and system |
JP2009061236A (ja) | 2007-09-07 | 2009-03-26 | Arimasa Nishida | 個人の医療情報のマルチデータ読み込み・入力機能、データ管理・解析・表示機能、健康自己管理を促すエンターテインメント・ゲーム機能と通信機能を備えた、生活習慣病についての強力なバイオフィードバック効果を持つ小型端末で、さらに医療機関、自治体あるいは国家レベルでの医療情報のデータベース化の際に、最初に個人の測定データを統一管理できる、小型端末。 |
US20090076397A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent Emergency Patient Monitor |
WO2009036313A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent device with multiple physiological sensors |
US8249686B2 (en) | 2007-09-14 | 2012-08-21 | Corventis, Inc. | Adherent device for sleep disordered breathing |
EP3922171A1 (en) | 2007-09-14 | 2021-12-15 | Medtronic Monitoring, Inc. | Adherent cardiac monitor with advanced sensing capabilities |
DK2192946T3 (da) | 2007-09-25 | 2022-11-21 | Otsuka Pharma Co Ltd | Kropsintern anordning med virtuel dipol signalforstærkning |
US20090105561A1 (en) | 2007-10-17 | 2009-04-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
SG190590A1 (en) | 2007-11-27 | 2013-06-28 | Proteus Digital Health Inc | Transbody communication systems employing communication channels |
US20090149839A1 (en) | 2007-12-11 | 2009-06-11 | Hyde Roderick A | Treatment techniques using ingestible device |
WO2009094050A1 (en) * | 2008-01-25 | 2009-07-30 | Medtronic, Inc. | Sleep stage detection |
JP5156427B2 (ja) | 2008-02-13 | 2013-03-06 | 富士フイルム株式会社 | カプセル内視鏡システム |
WO2009112972A2 (en) | 2008-03-10 | 2009-09-17 | Koninklijke Philips Electronics, N.V. | Continuous outpatient ecg monitoring system |
JP5495240B2 (ja) | 2008-03-10 | 2014-05-21 | コーニンクレッカ フィリップス エヌ ヴェ | 設定可能な警告リミットを持つecg監視システム |
US20090253960A1 (en) | 2008-04-03 | 2009-10-08 | Olympus Medical Systems Corp. | Antenna unit and receiving apparatus for capsule medical apparatus |
US20090292194A1 (en) | 2008-05-23 | 2009-11-26 | Corventis, Inc. | Chiropractic Care Management Systems and Methods |
CH699071A2 (fr) | 2008-07-02 | 2010-01-15 | Flakes S A | Dispositif de freinage et/ou de blocage mécanique. |
SG195535A1 (en) | 2008-07-08 | 2013-12-30 | Proteus Digital Health Inc | Ingestible event marker data framework |
US8152020B2 (en) | 2008-07-09 | 2012-04-10 | Flowers Mary E | Dosage dispensing and tracking container |
US8540633B2 (en) | 2008-08-13 | 2013-09-24 | Proteus Digital Health, Inc. | Identifier circuits for generating unique identifiable indicators and techniques for producing same |
KR101028584B1 (ko) | 2008-08-27 | 2011-04-12 | 주식회사 바이오프로테크 | 일회용 유도전극 및 이에 접속되는 리드선 |
GB2463054A (en) | 2008-08-30 | 2010-03-03 | Adavanced Telecare Solutions L | Device for monitoring the removal of items placed in compartments of a blister package using ambient light |
US20100063841A1 (en) | 2008-09-05 | 2010-03-11 | Vital Data Technology, Llc | System and method of notifying designated entities of access to personal medical records |
WO2010057049A2 (en) | 2008-11-13 | 2010-05-20 | Proteus Biomedical, Inc. | Ingestible therapy activator system and method |
CN102271578B (zh) | 2008-12-11 | 2013-12-04 | 普罗秋斯数字健康公司 | 使用便携式电子内脏造影系统的胃肠功能的评估及其使用方法 |
TWI503101B (zh) | 2008-12-15 | 2015-10-11 | Proteus Digital Health Inc | 與身體有關的接收器及其方法 |
US20100160742A1 (en) | 2008-12-18 | 2010-06-24 | General Electric Company | Telemetry system and method |
JP2012514799A (ja) | 2009-01-06 | 2012-06-28 | プロテウス バイオメディカル インコーポレイテッド | 摂取に関連するバイオフィードバックおよび個別薬物療法の方法およびシステム |
TW201036606A (en) | 2009-01-06 | 2010-10-16 | Proteus Biomedical Inc | High-throughput production of ingestible event markers |
KR100927471B1 (ko) | 2009-01-07 | 2009-11-19 | 주식회사 두성기술 | 가슴 부착 분리형 무선 심박 측정 장치 |
US8224667B1 (en) | 2009-02-06 | 2012-07-17 | Sprint Communications Company L.P. | Therapy adherence methods and architecture |
US8395521B2 (en) | 2009-02-06 | 2013-03-12 | University Of Dayton | Smart aerospace structures |
WO2010115194A1 (en) | 2009-04-03 | 2010-10-07 | Intrapace, Inc. | Feedback systems and methods for communicating diagnostic and/or treatment signals to enhance obesity treatments |
WO2010129288A2 (en) | 2009-04-28 | 2010-11-11 | Proteus Biomedical, Inc. | Highly reliable ingestible event markers and methods for using the same |
WO2010132331A2 (en) | 2009-05-12 | 2010-11-18 | Proteus Biomedical, Inc. | Ingestible event markers comprising an ingestible component |
US20100299155A1 (en) | 2009-05-19 | 2010-11-25 | Myca Health, Inc. | System and method for providing a multi-dimensional contextual platform for managing a medical practice |
US8440274B2 (en) | 2009-05-26 | 2013-05-14 | Apple Inc. | Electronic device moisture indicators |
US8468115B2 (en) | 2009-06-25 | 2013-06-18 | George Mason Intellectual Properties, Inc. | Cyclical behavior modification |
US9024766B2 (en) | 2009-08-28 | 2015-05-05 | The Invention Science Fund, Llc | Beverage containers with detection capability |
UA109424C2 (uk) | 2009-12-02 | 2015-08-25 | Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки | |
US9451897B2 (en) | 2009-12-14 | 2016-09-27 | Medtronic Monitoring, Inc. | Body adherent patch with electronics for physiologic monitoring |
US20130030259A1 (en) | 2009-12-23 | 2013-01-31 | Delta, Dansk Elektronik, Lys Og Akustik | Monitoring system |
US8560040B2 (en) | 2010-01-04 | 2013-10-15 | Koninklijke Philips N.V. | Shielded biomedical electrode patch |
KR101034998B1 (ko) | 2010-02-18 | 2011-05-17 | 대한메디칼시스템(주) | 스냅전극과 와이어의 체결구조 |
WO2011133799A1 (en) | 2010-04-21 | 2011-10-27 | Northwestern University | Medical evaluation system and method using sensors in mobile devices |
EP3387991B1 (en) | 2010-05-12 | 2022-06-15 | Irhythm Technologies, Inc. | Device features and design elements for long-term adhesion |
US8301232B2 (en) | 2010-06-08 | 2012-10-30 | Alivecor, Inc. | Wireless, ultrasonic personal health monitoring system |
US20110301439A1 (en) | 2010-06-08 | 2011-12-08 | AliveUSA LLC | Wireless, ultrasonic personal health monitoring system |
SG186282A1 (en) | 2010-06-14 | 2013-01-30 | Trutag Technologies Inc | System for verifying an item in a package |
EP2580688A4 (en) | 2010-06-14 | 2017-05-10 | Trutag Technologies, Inc. | Labeling and verifying an item with an identifier |
CN103189855B (zh) | 2010-06-14 | 2016-10-19 | 特鲁塔格科技公司 | 用于使用数据库验证包装中的物品的系统 |
KR20130057451A (ko) | 2010-06-14 | 2013-05-31 | 트루테그 테크놀로지스, 인코포레이티드 | 식별자를 가진 패키징된 아이템을 생성하기 위한 시스템 |
US9585620B2 (en) | 2010-07-27 | 2017-03-07 | Carefusion 303, Inc. | Vital-signs patch having a flexible attachment to electrodes |
USD639437S1 (en) | 2010-10-08 | 2011-06-07 | Cardiac Science Corporation | Wearable ambulatory electrocardiographic monitor |
US20120089000A1 (en) | 2010-10-08 | 2012-04-12 | Jon Mikalson Bishay | Ambulatory Electrocardiographic Monitor For Providing Ease Of Use In Women And Method Of Use |
CN102753088B (zh) | 2011-01-18 | 2014-08-27 | 北京超思电子技术股份有限公司 | 测量设备 |
US20120197144A1 (en) | 2011-01-27 | 2012-08-02 | Koninklijke Philips Electronics N.V. | Exchangeable electrode and ecg cable snap connector |
GB2487758A (en) | 2011-02-03 | 2012-08-08 | Isansys Lifecare Ltd | Health monitoring electrode assembly |
US9626650B2 (en) | 2011-04-14 | 2017-04-18 | Elwha Llc | Cost-effective resource apportionment technologies suitable for facilitating therapies |
-
2008
- 2008-11-26 SG SG2013032040A patent/SG190590A1/en unknown
- 2008-11-26 DK DK08853901.0T patent/DK2215726T3/en active
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- 2008-11-26 US US12/324,798 patent/US20090135886A1/en not_active Abandoned
- 2008-11-26 WO PCT/US2008/085048 patent/WO2009070773A1/en active Application Filing
- 2008-11-26 JP JP2010536201A patent/JP5794782B2/ja active Active
- 2008-11-26 ES ES08853901.0T patent/ES2661739T3/es active Active
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-
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- 2020-02-12 US US16/789,361 patent/US11612321B2/en active Active
Patent Citations (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3799802A (en) * | 1966-06-28 | 1974-03-26 | F Schneble | Plated through hole printed circuit boards |
US3642008A (en) * | 1968-09-25 | 1972-02-15 | Medical Plastics Inc | Ground electrode and test circuit |
US3719183A (en) * | 1970-03-05 | 1973-03-06 | H Schwartz | Method for detecting blockage or insufficiency of pancreatic exocrine function |
US4077397A (en) * | 1974-10-07 | 1978-03-07 | Baxter Travenol Laboratories, Inc. | Diagnostic electrode assembly |
US4077398A (en) * | 1974-10-07 | 1978-03-07 | Baxter Travenol Laboratories, Inc. | Diagnostic electrode assembly |
US4251795A (en) * | 1977-11-29 | 1981-02-17 | Asahi Kasei Kogyo Kabushiki Kaisha | Semiconductor magnetoresistive element having a differential effect |
US4578061A (en) * | 1980-10-28 | 1986-03-25 | Lemelson Jerome H | Injection catheter and method |
US4494950A (en) * | 1982-01-19 | 1985-01-22 | The Johns Hopkins University | Plural module medication delivery system |
US4681111A (en) * | 1985-04-05 | 1987-07-21 | Siemens-Pacesetter, Inc. | Analog and digital telemetry system for an implantable device |
US4635641A (en) * | 1985-10-16 | 1987-01-13 | Murray Electronics Associates Limited | Multi-element electrode |
US5281287A (en) * | 1989-07-21 | 1994-01-25 | Iomed, Inc. | Method of making a hydratable bioelectrode |
US7004395B2 (en) * | 1990-05-25 | 2006-02-28 | Broadcom Corporation | Multi-level hierarchical radio-frequency communication system |
US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
US5394882A (en) * | 1993-07-21 | 1995-03-07 | Respironics, Inc. | Physiological monitoring system |
US5862803A (en) * | 1993-09-04 | 1999-01-26 | Besson; Marcus | Wireless medical diagnosis and monitoring equipment |
US5600548A (en) * | 1994-08-11 | 1997-02-04 | Sundstrand Corporation | DC content control for an inverter |
US5705189A (en) * | 1994-08-31 | 1998-01-06 | Roehm Gmbh Chemische Fabrik | Thermoplastic material for drug coatings which dissolve in intestinal juices |
US20020032385A1 (en) * | 1995-02-24 | 2002-03-14 | Raymond Stephen A. | Health monitoring system |
US6083248A (en) * | 1995-06-23 | 2000-07-04 | Medtronic, Inc. | World wide patient location and data telemetry system for implantable medical devices |
US5868136A (en) * | 1996-02-20 | 1999-02-09 | Axelgaard Manufacturing Co. Ltd. | Medical electrode |
US20090016102A1 (en) * | 1996-05-01 | 2009-01-15 | Yusuke Jyouno | Nonvolatile semiconductor memory device which stores multi-value information |
US5862808A (en) * | 1997-08-26 | 1999-01-26 | Cigar Savor Enterprises Llc | Cigar punch |
US6038464A (en) * | 1998-02-09 | 2000-03-14 | Axelgaard Manufacturing Co., Ltd. | Medical electrode |
US20030028226A1 (en) * | 1998-06-19 | 2003-02-06 | Medtronic, Inc. | Medical management system integrated programming apparatus for communication with an implantable medical device |
US20050021103A1 (en) * | 1998-08-05 | 2005-01-27 | Dilorenzo Daniel John | Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease |
US7164942B2 (en) * | 1998-11-09 | 2007-01-16 | Transpharma Medical Ltd. | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
US6358202B1 (en) * | 1999-01-25 | 2002-03-19 | Sun Microsystems, Inc. | Network for implanted computer devices |
US6200265B1 (en) * | 1999-04-16 | 2001-03-13 | Medtronic, Inc. | Peripheral memory patch and access method for use with an implantable medical device |
US6845272B1 (en) * | 1999-05-25 | 2005-01-18 | Medicotest A/S | Skin electrode |
US6531026B1 (en) * | 1999-06-23 | 2003-03-11 | Sony Chemicals Corp. | Method for mounting electronic elements |
US20050024198A1 (en) * | 1999-07-20 | 2005-02-03 | Ward William H. | Impedance matching network and multidimensional electromagnetic field coil for a transponder interrogator |
US20060068006A1 (en) * | 1999-08-05 | 2006-03-30 | Dimensional Foods Corporation | Edible holographic products, particularly pharmaceuticals and methods and apparatus for producing same |
US7013162B2 (en) * | 1999-09-21 | 2006-03-14 | Ipr Licensing, Inc. | Dual mode unit for short range, high rate and long range, lower rate data communications |
US7668437B1 (en) * | 1999-09-30 | 2010-02-23 | Sony Corporation | Recording apparatus, recording method, and record medium |
US6990082B1 (en) * | 1999-11-08 | 2006-01-24 | Intel Corporation | Wireless apparatus having a transceiver equipped to support multiple wireless communication protocols |
US6526315B1 (en) * | 2000-03-17 | 2003-02-25 | Tanita Corporation | Portable bioelectrical impedance measuring instrument |
US6987965B2 (en) * | 2000-04-18 | 2006-01-17 | Motorola, Inc. | Programmable wireless electrode system for medical monitoring |
US7171166B2 (en) * | 2000-04-18 | 2007-01-30 | Motorola Inc. | Programmable wireless electrode system for medical monitoring |
US6680923B1 (en) * | 2000-05-23 | 2004-01-20 | Calypso Wireless, Inc. | Communication system and method |
US7647185B2 (en) * | 2000-06-16 | 2010-01-12 | Oxford Biosignals Limited | Combining measurements from different sensors |
US6839659B2 (en) * | 2000-06-16 | 2005-01-04 | Isis Innovation Limited | System and method for acquiring data |
US7009946B1 (en) * | 2000-06-22 | 2006-03-07 | Intel Corporation | Method and apparatus for multi-access wireless communication |
US20020026111A1 (en) * | 2000-08-28 | 2002-02-28 | Neil Ackerman | Methods of monitoring glucose levels in a subject and uses thereof |
US20050021370A1 (en) * | 2000-08-29 | 2005-01-27 | Medtronic, Inc. | Medical device systems implemented network scheme for remote patient management |
US20050017841A1 (en) * | 2000-09-08 | 2005-01-27 | Matsushita Electric Works, Ltd. | Data transmission system using a human body as a signal transmission path |
US6864780B2 (en) * | 2000-09-08 | 2005-03-08 | Matsushita Electric Works, Ltd. | Data transmission system using a human body as a signal transmission path |
US20040034295A1 (en) * | 2000-09-26 | 2004-02-19 | Marcos Salganicoff | Method and apparatus for real-time estimation and control of physiological parameters |
US20050192489A1 (en) * | 2000-11-08 | 2005-09-01 | Marshall Daniel R. | Swallowable data recorder capsule medical device |
US6342774B1 (en) * | 2001-03-27 | 2002-01-29 | Motorola, Inc. | Battery having user charge capacity control |
US7161484B2 (en) * | 2001-04-17 | 2007-01-09 | Micrel Medical Devices S.A. | System for monitoring medical parameters |
US7160258B2 (en) * | 2001-06-26 | 2007-01-09 | Entrack, Inc. | Capsule and method for treating or diagnosing the intestinal tract |
US20070060800A1 (en) * | 2001-06-29 | 2007-03-15 | Darrel Drinan | Gateway platform for biological monitoring and delivery of therapeutic compounds |
US20050020887A1 (en) * | 2001-10-11 | 2005-01-27 | Jason Goldberg | Medical monitoring device and system |
US20050027205A1 (en) * | 2001-12-14 | 2005-02-03 | Lionel Tarassenko | Combining measurements from breathing rate sensors |
US7318808B2 (en) * | 2001-12-14 | 2008-01-15 | Isis Innovation Limited | Combining measurements from breathing rate sensors |
US7016648B2 (en) * | 2001-12-18 | 2006-03-21 | Ixi Mobile (Israel) Ltd. | Method, system and computer readable medium for downloading a software component to a device in a short distance wireless network |
US20040121292A1 (en) * | 2002-08-08 | 2004-06-24 | Chung Bobby Hsiang-Hua | Wireless data communication link embedded in simulated weapon systems |
US20060028727A1 (en) * | 2002-08-20 | 2006-02-09 | Moon John A | Method and apparatus for drug product tracking using encoded optical identification elements |
US7020508B2 (en) * | 2002-08-22 | 2006-03-28 | Bodymedia, Inc. | Apparatus for detecting human physiological and contextual information |
US20060036134A1 (en) * | 2002-09-18 | 2006-02-16 | E-San Limited | Telemedicine system |
US20040122315A1 (en) * | 2002-09-24 | 2004-06-24 | Krill Jerry A. | Ingestible medical payload carrying capsule with wireless communication |
US6842636B2 (en) * | 2002-09-27 | 2005-01-11 | Axelgaard Manufacturing Co., Ltd. | Medical electrode |
US20090030297A1 (en) * | 2002-09-27 | 2009-01-29 | Medtronic Minimed, Inc. | Implantable sensor method and system |
US20040092296A1 (en) * | 2002-10-31 | 2004-05-13 | Tadashi Minotani | Transceiver capable of causing series resonance with parasitic capacitance |
US20040186365A1 (en) * | 2002-12-31 | 2004-09-23 | Therasense, Inc. | Continuous glucose monitoring system and methods of use |
US7653031B2 (en) * | 2003-03-05 | 2010-01-26 | Timothy Gordon Godfrey | Advance notification of transmit opportunities on a shared-communications channel |
US7382247B2 (en) * | 2003-03-21 | 2008-06-03 | Welch Allyn, Inc. | Personal status physiologic monitor system and architecture and related monitoring methods |
US7640802B2 (en) * | 2003-04-11 | 2010-01-05 | Oxford Biosignals Limited | Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components |
US20070006636A1 (en) * | 2003-04-11 | 2007-01-11 | Oxford Biosignals Limited | Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components |
US7171259B2 (en) * | 2003-04-17 | 2007-01-30 | Polar Electro Oy | Method and device for measuring heart rate, and method for manufacturing the device |
US20070027386A1 (en) * | 2003-07-16 | 2007-02-01 | Koninklijke Philips Electronics N.V. | Portable electronic device and a health management system arranged for monitoring a physiological condition of an individual |
US20050070778A1 (en) * | 2003-08-20 | 2005-03-31 | Lackey Robert P. | Hydration monitoring |
US20050043894A1 (en) * | 2003-08-22 | 2005-02-24 | Fernandez Dennis S. | Integrated biosensor and simulation system for diagnosis and therapy |
US20050062644A1 (en) * | 2003-09-08 | 2005-03-24 | Leci Jonathan Ilan | Capsule device to identify the location of an individual |
US20050065407A1 (en) * | 2003-09-18 | 2005-03-24 | Olympus Corporation | Energy supplying coil and capsule endoscope system |
US7176784B2 (en) * | 2004-01-21 | 2007-02-13 | Battelle Memorial Institute K1-53 | Multi-mode radio frequency device |
US7647112B2 (en) * | 2004-02-11 | 2010-01-12 | Ethicon, Inc. | System and method for selectively stimulating different body parts |
US20070002038A1 (en) * | 2004-04-07 | 2007-01-04 | Olympus Corporation | Intra-subject position display system |
US20080051667A1 (en) * | 2004-05-16 | 2008-02-28 | Rami Goldreich | Method And Device For Measuring Physiological Parameters At The Hand |
US20070038054A1 (en) * | 2004-05-20 | 2007-02-15 | Peter Zhou | Embedded bio-sensor system |
US20080033273A1 (en) * | 2004-05-20 | 2008-02-07 | Peter Zhou | Embedded Bio-Sensor System |
US20080021519A1 (en) * | 2004-05-28 | 2008-01-24 | Jan De Geest | Communication Unit for a Person's Skin |
US7336929B2 (en) * | 2004-07-05 | 2008-02-26 | Sony Ericsson Mobile Communications Japan, Inc. | Short range wireless communication system, portable terminal apparatus, and wireless communication apparatus |
US20060030760A1 (en) * | 2004-07-20 | 2006-02-09 | Geiger Mark A | Vital signs monitoring system with wireless pupilometer interface |
US20080027679A1 (en) * | 2004-07-21 | 2008-01-31 | Dror Shklarski | Wearable Device, System and Method for Measuring Physiological and/or Environmental Parameters |
US20080045843A1 (en) * | 2004-08-12 | 2008-02-21 | Tomoharu Tsuji | Via-Human-Body Information Transmission System and Transmitter-Receiver |
US20060058602A1 (en) * | 2004-08-17 | 2006-03-16 | Kwiatkowski Krzysztof C | Interstitial fluid analyzer |
US7171177B2 (en) * | 2004-09-07 | 2007-01-30 | Electronics And Telecommunications Research Institute | Communication apparatus and method using human body as medium |
US20060183993A1 (en) * | 2004-12-30 | 2006-08-17 | Eli Horn | Device, system, and method for locating an in-vivo signal source |
US20060164213A1 (en) * | 2005-01-26 | 2006-07-27 | Battelle Memorial Institute | Method for autonomous establishment and utilization of an active-RF tag network |
US20060229053A1 (en) * | 2005-04-06 | 2006-10-12 | Zarlink Semiconductor Ab | Implantable RF telemetry devices with power saving mode |
US20070016089A1 (en) * | 2005-07-15 | 2007-01-18 | Fischell David R | Implantable device for vital signs monitoring |
US20070123772A1 (en) * | 2005-07-20 | 2007-05-31 | Neil Euliano | Medication compliance system and associated methods |
US20070027388A1 (en) * | 2005-08-01 | 2007-02-01 | Chang-An Chou | Patch-type physiological monitoring apparatus, system and network |
US20070049339A1 (en) * | 2005-08-29 | 2007-03-01 | Amit Barak | Method and apparatus of multiple entity wireless communication adapter |
US20070060797A1 (en) * | 2005-08-31 | 2007-03-15 | Ball James J | Automatic parameter status on an implantable medical device system |
US20100027411A1 (en) * | 2005-10-26 | 2010-02-04 | Thomson Licensing | System and Method for Compensating for a Satellite Gateway Failure |
US20100049006A1 (en) * | 2006-02-24 | 2010-02-25 | Surendar Magar | Medical signal processing system with distributed wireless sensors |
US20080051647A1 (en) * | 2006-05-11 | 2008-02-28 | Changwang Wu | Non-invasive acquisition of large nerve action potentials (NAPs) with closely spaced surface electrodes and reduced stimulus artifacts |
US20080046038A1 (en) * | 2006-06-26 | 2008-02-21 | Hill Gerard J | Local communications network for distributed sensing and therapy in biomedical applications |
US20080014866A1 (en) * | 2006-07-12 | 2008-01-17 | Lipowski Joseph T | Transceiver architecture and method for wireless base-stations |
US20080021521A1 (en) * | 2006-07-18 | 2008-01-24 | Cardiac Pacemakers, Inc. | Implantable Medical Device Communication System |
US20100049012A1 (en) * | 2006-11-21 | 2010-02-25 | Koninklijke Philips Electronics N.V. | Ingestible electronic capsule and in vivo drug delivery or diagnostic system |
US20100049069A1 (en) * | 2006-12-01 | 2010-02-25 | Oxford Biosignals Limited | Biomedical signal morphology analysis method |
US20080316020A1 (en) * | 2007-05-24 | 2008-12-25 | Robertson Timothy L | Rfid antenna for in-body device |
US20100010330A1 (en) * | 2007-06-01 | 2010-01-14 | Medtronic Minimed, Inc. | Wireless monitor for a personal medical device system |
US20090009330A1 (en) * | 2007-07-03 | 2009-01-08 | Isao Sakama | Rfid tag mounting circuit board |
US20090043171A1 (en) * | 2007-07-16 | 2009-02-12 | Peter Rule | Systems And Methods For Determining Physiological Parameters Using Measured Analyte Values |
US20090024045A1 (en) * | 2007-07-19 | 2009-01-22 | Rajan Prakash | Mechanical function marker channel for cardiac monitoring and therapy control |
US20090034209A1 (en) * | 2007-08-03 | 2009-02-05 | Samsung Electronics Co., Ltd. | Multi-module combination type portable electronic device |
US20090048498A1 (en) * | 2007-08-17 | 2009-02-19 | Frank Riskey | System and method of monitoring an animal |
US20100049004A1 (en) * | 2008-04-21 | 2010-02-25 | Philometron, Inc. | Metabolic energy monitoring system |
US20100001841A1 (en) * | 2008-07-07 | 2010-01-07 | Cardullo Mario W | Dynamically distributable nano rfid device and related method |
Non-Patent Citations (2)
Title |
---|
"Modulation and Deviation" by Dave Platt, AE6EO, 10/26/2007 * |
Collins English Dictionary definition of "Digest" * |
Cited By (227)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8912908B2 (en) | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
US10542909B2 (en) | 2005-04-28 | 2020-01-28 | Proteus Digital Health, Inc. | Communication system with partial power source |
US7978064B2 (en) | 2005-04-28 | 2011-07-12 | Proteus Biomedical, Inc. | Communication system with partial power source |
US11476952B2 (en) | 2005-04-28 | 2022-10-18 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
US9119554B2 (en) | 2005-04-28 | 2015-09-01 | Proteus Digital Health, Inc. | Pharma-informatics system |
US10610128B2 (en) | 2005-04-28 | 2020-04-07 | Proteus Digital Health, Inc. | Pharma-informatics system |
US9439582B2 (en) | 2005-04-28 | 2016-09-13 | Proteus Digital Health, Inc. | Communication system with remote activation |
US8847766B2 (en) | 2005-04-28 | 2014-09-30 | Proteus Digital Health, Inc. | Pharma-informatics system |
US9198608B2 (en) | 2005-04-28 | 2015-12-01 | Proteus Digital Health, Inc. | Communication system incorporated in a container |
US9161707B2 (en) | 2005-04-28 | 2015-10-20 | Proteus Digital Health, Inc. | Communication system incorporated in an ingestible product |
US9962107B2 (en) | 2005-04-28 | 2018-05-08 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US9597010B2 (en) | 2005-04-28 | 2017-03-21 | Proteus Digital Health, Inc. | Communication system using an implantable device |
US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US8730031B2 (en) | 2005-04-28 | 2014-05-20 | Proteus Digital Health, Inc. | Communication system using an implantable device |
US8674825B2 (en) | 2005-04-28 | 2014-03-18 | Proteus Digital Health, Inc. | Pharma-informatics system |
US9681842B2 (en) | 2005-04-28 | 2017-06-20 | Proteus Digital Health, Inc. | Pharma-informatics system |
US10517507B2 (en) | 2005-04-28 | 2019-12-31 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US8816847B2 (en) | 2005-04-28 | 2014-08-26 | Proteus Digital Health, Inc. | Communication system with partial power source |
US9649066B2 (en) | 2005-04-28 | 2017-05-16 | Proteus Digital Health, Inc. | Communication system with partial power source |
US20080284599A1 (en) * | 2005-04-28 | 2008-11-20 | Proteus Biomedical, Inc. | Pharma-Informatics System |
US8547248B2 (en) | 2005-09-01 | 2013-10-01 | Proteus Digital Health, Inc. | Implantable zero-wire communications system |
US8836513B2 (en) | 2006-04-28 | 2014-09-16 | Proteus Digital Health, Inc. | Communication system incorporated in an ingestible product |
US11928614B2 (en) | 2006-05-02 | 2024-03-12 | Otsuka Pharmaceutical Co., Ltd. | Patient customized therapeutic regimens |
US20080020037A1 (en) * | 2006-07-11 | 2008-01-24 | Robertson Timothy L | Acoustic Pharma-Informatics System |
US8054140B2 (en) | 2006-10-17 | 2011-11-08 | Proteus Biomedical, Inc. | Low voltage oscillator for medical devices |
US8945005B2 (en) | 2006-10-25 | 2015-02-03 | Proteus Digital Health, Inc. | Controlled activation ingestible identifier |
US10238604B2 (en) | 2006-10-25 | 2019-03-26 | Proteus Digital Health, Inc. | Controlled activation ingestible identifier |
US11357730B2 (en) | 2006-10-25 | 2022-06-14 | Otsuka Pharmaceutical Co., Ltd. | Controlled activation ingestible identifier |
US9083589B2 (en) | 2006-11-20 | 2015-07-14 | Proteus Digital Health, Inc. | Active signal processing personal health signal receivers |
US8718193B2 (en) | 2006-11-20 | 2014-05-06 | Proteus Digital Health, Inc. | Active signal processing personal health signal receivers |
US9444503B2 (en) | 2006-11-20 | 2016-09-13 | Proteus Digital Health, Inc. | Active signal processing personal health signal receivers |
US10441194B2 (en) | 2007-02-01 | 2019-10-15 | Proteus Digital Heal Th, Inc. | Ingestible event marker systems |
US8858432B2 (en) | 2007-02-01 | 2014-10-14 | Proteus Digital Health, Inc. | Ingestible event marker systems |
US8956288B2 (en) | 2007-02-14 | 2015-02-17 | Proteus Digital Health, Inc. | In-body power source having high surface area electrode |
US11464423B2 (en) | 2007-02-14 | 2022-10-11 | Otsuka Pharmaceutical Co., Ltd. | In-body power source having high surface area electrode |
US8932221B2 (en) | 2007-03-09 | 2015-01-13 | Proteus Digital Health, Inc. | In-body device having a multi-directional transmitter |
US9270025B2 (en) | 2007-03-09 | 2016-02-23 | Proteus Digital Health, Inc. | In-body device having deployable antenna |
US8540632B2 (en) | 2007-05-24 | 2013-09-24 | Proteus Digital Health, Inc. | Low profile antenna for in body device |
US8115618B2 (en) | 2007-05-24 | 2012-02-14 | Proteus Biomedical, Inc. | RFID antenna for in-body device |
US10517506B2 (en) | 2007-05-24 | 2019-12-31 | Proteus Digital Health, Inc. | Low profile antenna for in body device |
US8961412B2 (en) | 2007-09-25 | 2015-02-24 | Proteus Digital Health, Inc. | In-body device with virtual dipole signal amplification |
US9433371B2 (en) | 2007-09-25 | 2016-09-06 | Proteus Digital Health, Inc. | In-body device with virtual dipole signal amplification |
US11612321B2 (en) | 2007-11-27 | 2023-03-28 | Otsuka Pharmaceutical Co., Ltd. | Transbody communication systems employing communication channels |
US9258035B2 (en) | 2008-03-05 | 2016-02-09 | Proteus Digital Health, Inc. | Multi-mode communication ingestible event markers and systems, and methods of using the same |
US9060708B2 (en) | 2008-03-05 | 2015-06-23 | Proteus Digital Health, Inc. | Multi-mode communication ingestible event markers and systems, and methods of using the same |
US8258962B2 (en) | 2008-03-05 | 2012-09-04 | Proteus Biomedical, Inc. | Multi-mode communication ingestible event markers and systems, and methods of using the same |
US8810409B2 (en) | 2008-03-05 | 2014-08-19 | Proteus Digital Health, Inc. | Multi-mode communication ingestible event markers and systems, and methods of using the same |
US8542123B2 (en) | 2008-03-05 | 2013-09-24 | Proteus Digital Health, Inc. | Multi-mode communication ingestible event markers and systems, and methods of using the same |
US9603550B2 (en) | 2008-07-08 | 2017-03-28 | Proteus Digital Health, Inc. | State characterization based on multi-variate data fusion techniques |
US11217342B2 (en) | 2008-07-08 | 2022-01-04 | Otsuka Pharmaceutical Co., Ltd. | Ingestible event marker data framework |
US10682071B2 (en) | 2008-07-08 | 2020-06-16 | Proteus Digital Health, Inc. | State characterization based on multi-variate data fusion techniques |
US8721540B2 (en) | 2008-08-13 | 2014-05-13 | Proteus Digital Health, Inc. | Ingestible circuitry |
US8540633B2 (en) | 2008-08-13 | 2013-09-24 | Proteus Digital Health, Inc. | Identifier circuits for generating unique identifiable indicators and techniques for producing same |
US9415010B2 (en) | 2008-08-13 | 2016-08-16 | Proteus Digital Health, Inc. | Ingestible circuitry |
US8036748B2 (en) | 2008-11-13 | 2011-10-11 | Proteus Biomedical, Inc. | Ingestible therapy activator system and method |
US8583227B2 (en) | 2008-12-11 | 2013-11-12 | Proteus Digital Health, Inc. | Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same |
US8545436B2 (en) | 2008-12-15 | 2013-10-01 | Proteus Digital Health, Inc. | Body-associated receiver and method |
US9439566B2 (en) | 2008-12-15 | 2016-09-13 | Proteus Digital Health, Inc. | Re-wearable wireless device |
US8114021B2 (en) | 2008-12-15 | 2012-02-14 | Proteus Biomedical, Inc. | Body-associated receiver and method |
US9659423B2 (en) | 2008-12-15 | 2017-05-23 | Proteus Digital Health, Inc. | Personal authentication apparatus system and method |
US9149577B2 (en) | 2008-12-15 | 2015-10-06 | Proteus Digital Health, Inc. | Body-associated receiver and method |
US8597186B2 (en) | 2009-01-06 | 2013-12-03 | Proteus Digital Health, Inc. | Pharmaceutical dosages delivery system |
US9883819B2 (en) | 2009-01-06 | 2018-02-06 | Proteus Digital Health, Inc. | Ingestion-related biofeedback and personalized medical therapy method and system |
US9119918B2 (en) | 2009-03-25 | 2015-09-01 | Proteus Digital Health, Inc. | Probablistic pharmacokinetic and pharmacodynamic modeling |
US8540664B2 (en) | 2009-03-25 | 2013-09-24 | Proteus Digital Health, Inc. | Probablistic pharmacokinetic and pharmacodynamic modeling |
US8545402B2 (en) | 2009-04-28 | 2013-10-01 | Proteus Digital Health, Inc. | Highly reliable ingestible event markers and methods for using the same |
US9320455B2 (en) | 2009-04-28 | 2016-04-26 | Proteus Digital Health, Inc. | Highly reliable ingestible event markers and methods for using the same |
US10588544B2 (en) | 2009-04-28 | 2020-03-17 | Proteus Digital Health, Inc. | Highly reliable ingestible event markers and methods for using the same |
US9149423B2 (en) | 2009-05-12 | 2015-10-06 | Proteus Digital Health, Inc. | Ingestible event markers comprising an ingestible component |
US8558563B2 (en) | 2009-08-21 | 2013-10-15 | Proteus Digital Health, Inc. | Apparatus and method for measuring biochemical parameters |
US10305544B2 (en) | 2009-11-04 | 2019-05-28 | Proteus Digital Health, Inc. | System for supply chain management |
US9941931B2 (en) | 2009-11-04 | 2018-04-10 | Proteus Digital Health, Inc. | System for supply chain management |
US8868453B2 (en) | 2009-11-04 | 2014-10-21 | Proteus Digital Health, Inc. | System for supply chain management |
US8784308B2 (en) | 2009-12-02 | 2014-07-22 | Proteus Digital Health, Inc. | Integrated ingestible event marker system with pharmaceutical product |
US9014779B2 (en) | 2010-02-01 | 2015-04-21 | Proteus Digital Health, Inc. | Data gathering system |
US10376218B2 (en) | 2010-02-01 | 2019-08-13 | Proteus Digital Health, Inc. | Data gathering system |
US10207093B2 (en) | 2010-04-07 | 2019-02-19 | Proteus Digital Health, Inc. | Miniature ingestible device |
US11173290B2 (en) | 2010-04-07 | 2021-11-16 | Otsuka Pharmaceutical Co., Ltd. | Miniature ingestible device |
US9597487B2 (en) | 2010-04-07 | 2017-03-21 | Proteus Digital Health, Inc. | Miniature ingestible device |
US10529044B2 (en) | 2010-05-19 | 2020-01-07 | Proteus Digital Health, Inc. | Tracking and delivery confirmation of pharmaceutical products |
WO2012042437A3 (en) * | 2010-09-30 | 2012-06-21 | Koninklijke Philips Electronics N.V. | Body worn sensors network with redundant parameter prioritization and temporal alignment |
CN103124971A (zh) * | 2010-09-30 | 2013-05-29 | 皇家飞利浦电子股份有限公司 | 具有冗余参数优先级设置和时间对准的身体佩戴传感器网络 |
US10264968B2 (en) | 2010-09-30 | 2019-04-23 | Koninklijke Philips N.V. | Body worn sensors network with redundant parameter prioritization and temporal alignment |
WO2012042437A2 (en) | 2010-09-30 | 2012-04-05 | Koninklijke Philips Electronics N.V. | Body worn sensors network with redundant parameter prioritization and temporal alignment |
US9107806B2 (en) | 2010-11-22 | 2015-08-18 | Proteus Digital Health, Inc. | Ingestible device with pharmaceutical product |
US11504511B2 (en) | 2010-11-22 | 2022-11-22 | Otsuka Pharmaceutical Co., Ltd. | Ingestible device with pharmaceutical product |
CN106534854A (zh) * | 2011-03-07 | 2017-03-22 | 杜比国际公司 | 编码和解码图像的方法、编码和解码设备 |
US11343535B2 (en) | 2011-03-07 | 2022-05-24 | Dolby International Ab | Method of coding and decoding images, coding and decoding device and computer programs corresponding thereto |
US11736723B2 (en) | 2011-03-07 | 2023-08-22 | Dolby International Ab | Method of coding and decoding images, coding and decoding device and computer programs corresponding thereto |
US9439599B2 (en) | 2011-03-11 | 2016-09-13 | Proteus Digital Health, Inc. | Wearable personal body associated device with various physical configurations |
US9044137B2 (en) * | 2011-06-07 | 2015-06-02 | Olympus Corporation | Wireless communication terminal |
US20120315863A1 (en) * | 2011-06-07 | 2012-12-13 | Olympus Corporation | Wireless communication terminal |
US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
US11229378B2 (en) | 2011-07-11 | 2022-01-25 | Otsuka Pharmaceutical Co., Ltd. | Communication system with enhanced partial power source and method of manufacturing same |
US10223905B2 (en) | 2011-07-21 | 2019-03-05 | Proteus Digital Health, Inc. | Mobile device and system for detection and communication of information received from an ingestible device |
US9235683B2 (en) | 2011-11-09 | 2016-01-12 | Proteus Digital Health, Inc. | Apparatus, system, and method for managing adherence to a regimen |
US9271897B2 (en) | 2012-07-23 | 2016-03-01 | Proteus Digital Health, Inc. | Techniques for manufacturing ingestible event markers comprising an ingestible component |
US9031653B2 (en) | 2012-07-26 | 2015-05-12 | Nyxoah SA | Internal resonance matching between an implanted device and an external device |
US9268909B2 (en) | 2012-10-18 | 2016-02-23 | Proteus Digital Health, Inc. | Apparatus, system, and method to adaptively optimize power dissipation and broadcast power in a power source for a communication device |
US11149123B2 (en) | 2013-01-29 | 2021-10-19 | Otsuka Pharmaceutical Co., Ltd. | Highly-swellable polymeric films and compositions comprising the same |
US11158149B2 (en) | 2013-03-15 | 2021-10-26 | Otsuka Pharmaceutical Co., Ltd. | Personal authentication apparatus system and method |
US11741771B2 (en) | 2013-03-15 | 2023-08-29 | Otsuka Pharmaceutical Co., Ltd. | Personal authentication apparatus system and method |
US10175376B2 (en) | 2013-03-15 | 2019-01-08 | Proteus Digital Health, Inc. | Metal detector apparatus, system, and method |
US11744481B2 (en) | 2013-03-15 | 2023-09-05 | Otsuka Pharmaceutical Co., Ltd. | System, apparatus and methods for data collection and assessing outcomes |
US10421658B2 (en) | 2013-08-30 | 2019-09-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
US10097388B2 (en) | 2013-09-20 | 2018-10-09 | Proteus Digital Health, Inc. | Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping |
US9787511B2 (en) | 2013-09-20 | 2017-10-10 | Proteus Digital Health, Inc. | Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping |
US10498572B2 (en) | 2013-09-20 | 2019-12-03 | Proteus Digital Health, Inc. | Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping |
US9270503B2 (en) | 2013-09-20 | 2016-02-23 | Proteus Digital Health, Inc. | Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping |
US11102038B2 (en) | 2013-09-20 | 2021-08-24 | Otsuka Pharmaceutical Co., Ltd. | Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping |
US9577864B2 (en) | 2013-09-24 | 2017-02-21 | Proteus Digital Health, Inc. | Method and apparatus for use with received electromagnetic signal at a frequency not known exactly in advance |
CN105612492A (zh) * | 2013-10-02 | 2016-05-25 | 高通股份有限公司 | 用于产生伪随机数的可编程概率分布函数的方法和装置 |
US9417845B2 (en) * | 2013-10-02 | 2016-08-16 | Qualcomm Incorporated | Method and apparatus for producing programmable probability distribution function of pseudo-random numbers |
US20150095274A1 (en) * | 2013-10-02 | 2015-04-02 | Qualcomm Incorporated | Method and apparatus for producing programmable probability distribution function of pseudo-random numbers |
US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
US10722720B2 (en) | 2014-01-10 | 2020-07-28 | Cardiac Pacemakers, Inc. | Methods and systems for improved communication between medical devices |
US9592391B2 (en) | 2014-01-10 | 2017-03-14 | Cardiac Pacemakers, Inc. | Systems and methods for detecting cardiac arrhythmias |
US10398161B2 (en) | 2014-01-21 | 2019-09-03 | Proteus Digital Heal Th, Inc. | Masticable ingestible product and communication system therefor |
US11950615B2 (en) | 2014-01-21 | 2024-04-09 | Otsuka Pharmaceutical Co., Ltd. | Masticable ingestible product and communication system therefor |
US9694189B2 (en) | 2014-08-06 | 2017-07-04 | Cardiac Pacemakers, Inc. | Method and apparatus for communicating between medical devices |
US10912943B2 (en) | 2014-08-06 | 2021-02-09 | Cardiac Pacemakers, Inc. | Communications between a plurality of medical devices using time delays between communication pulses between symbols |
US9808631B2 (en) | 2014-08-06 | 2017-11-07 | Cardiac Pacemakers, Inc. | Communication between a plurality of medical devices using time delays between communication pulses to distinguish between symbols |
US9757570B2 (en) | 2014-08-06 | 2017-09-12 | Cardiac Pacemakers, Inc. | Communications in a medical device system |
US9526909B2 (en) | 2014-08-28 | 2016-12-27 | Cardiac Pacemakers, Inc. | Medical device with triggered blanking period |
US10238882B2 (en) | 2015-02-06 | 2019-03-26 | Cardiac Pacemakers | Systems and methods for treating cardiac arrhythmias |
US11224751B2 (en) | 2015-02-06 | 2022-01-18 | Cardiac Pacemakers, Inc. | Systems and methods for safe delivery of electrical stimulation therapy |
US11020595B2 (en) | 2015-02-06 | 2021-06-01 | Cardiac Pacemakers, Inc. | Systems and methods for treating cardiac arrhythmias |
US10220213B2 (en) | 2015-02-06 | 2019-03-05 | Cardiac Pacemakers, Inc. | Systems and methods for safe delivery of electrical stimulation therapy |
US9669230B2 (en) | 2015-02-06 | 2017-06-06 | Cardiac Pacemakers, Inc. | Systems and methods for treating cardiac arrhythmias |
US10046167B2 (en) | 2015-02-09 | 2018-08-14 | Cardiac Pacemakers, Inc. | Implantable medical device with radiopaque ID tag |
US11020600B2 (en) | 2015-02-09 | 2021-06-01 | Cardiac Pacemakers, Inc. | Implantable medical device with radiopaque ID tag |
US11285326B2 (en) | 2015-03-04 | 2022-03-29 | Cardiac Pacemakers, Inc. | Systems and methods for treating cardiac arrhythmias |
US10213610B2 (en) | 2015-03-18 | 2019-02-26 | Cardiac Pacemakers, Inc. | Communications in a medical device system with link quality assessment |
US10050700B2 (en) | 2015-03-18 | 2018-08-14 | Cardiac Pacemakers, Inc. | Communications in a medical device system with temporal optimization |
US11476927B2 (en) | 2015-03-18 | 2022-10-18 | Cardiac Pacemakers, Inc. | Communications in a medical device system with temporal optimization |
US10946202B2 (en) | 2015-03-18 | 2021-03-16 | Cardiac Pacemakers, Inc. | Communications in a medical device system with link quality assessment |
EP3070982A1 (de) * | 2015-03-19 | 2016-09-21 | Albert-Ludwigs-Universität Freiburg | Empfangseinrichtung und verfahren zum betreiben einer empfangseinrichtung |
US9985730B2 (en) | 2015-03-19 | 2018-05-29 | Albert-Ludwigs-Universität Freiburg | Wake-up circuit in receiving device and method of operating the receiving device |
US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
US9853743B2 (en) | 2015-08-20 | 2017-12-26 | Cardiac Pacemakers, Inc. | Systems and methods for communication between medical devices |
US10357159B2 (en) | 2015-08-20 | 2019-07-23 | Cardiac Pacemakers, Inc | Systems and methods for communication between medical devices |
US10709892B2 (en) | 2015-08-27 | 2020-07-14 | Cardiac Pacemakers, Inc. | Temporal configuration of a motion sensor in an implantable medical device |
US9968787B2 (en) | 2015-08-27 | 2018-05-15 | Cardiac Pacemakers, Inc. | Spatial configuration of a motion sensor in an implantable medical device |
US9956414B2 (en) | 2015-08-27 | 2018-05-01 | Cardiac Pacemakers, Inc. | Temporal configuration of a motion sensor in an implantable medical device |
US10159842B2 (en) | 2015-08-28 | 2018-12-25 | Cardiac Pacemakers, Inc. | System and method for detecting tamponade |
US10137305B2 (en) | 2015-08-28 | 2018-11-27 | Cardiac Pacemakers, Inc. | Systems and methods for behaviorally responsive signal detection and therapy delivery |
US10589101B2 (en) | 2015-08-28 | 2020-03-17 | Cardiac Pacemakers, Inc. | System and method for detecting tamponade |
US10226631B2 (en) | 2015-08-28 | 2019-03-12 | Cardiac Pacemakers, Inc. | Systems and methods for infarct detection |
US10092760B2 (en) | 2015-09-11 | 2018-10-09 | Cardiac Pacemakers, Inc. | Arrhythmia detection and confirmation |
US10065041B2 (en) | 2015-10-08 | 2018-09-04 | Cardiac Pacemakers, Inc. | Devices and methods for adjusting pacing rates in an implantable medical device |
US10183170B2 (en) | 2015-12-17 | 2019-01-22 | Cardiac Pacemakers, Inc. | Conducted communication in a medical device system |
US10933245B2 (en) | 2015-12-17 | 2021-03-02 | Cardiac Pacemakers, Inc. | Conducted communication in a medical device system |
US10905886B2 (en) | 2015-12-28 | 2021-02-02 | Cardiac Pacemakers, Inc. | Implantable medical device for deployment across the atrioventricular septum |
US10583303B2 (en) | 2016-01-19 | 2020-03-10 | Cardiac Pacemakers, Inc. | Devices and methods for wirelessly recharging a rechargeable battery of an implantable medical device |
US10350423B2 (en) | 2016-02-04 | 2019-07-16 | Cardiac Pacemakers, Inc. | Delivery system with force sensor for leadless cardiac device |
US11116988B2 (en) | 2016-03-31 | 2021-09-14 | Cardiac Pacemakers, Inc. | Implantable medical device with rechargeable battery |
US10668294B2 (en) | 2016-05-10 | 2020-06-02 | Cardiac Pacemakers, Inc. | Leadless cardiac pacemaker configured for over the wire delivery |
US10328272B2 (en) | 2016-05-10 | 2019-06-25 | Cardiac Pacemakers, Inc. | Retrievability for implantable medical devices |
US10512784B2 (en) | 2016-06-27 | 2019-12-24 | Cardiac Pacemakers, Inc. | Cardiac therapy system using subcutaneously sensed P-waves for resynchronization pacing management |
US11497921B2 (en) | 2016-06-27 | 2022-11-15 | Cardiac Pacemakers, Inc. | Cardiac therapy system using subcutaneously sensed p-waves for resynchronization pacing management |
US11207527B2 (en) | 2016-07-06 | 2021-12-28 | Cardiac Pacemakers, Inc. | Method and system for determining an atrial contraction timing fiducial in a leadless cardiac pacemaker system |
US10426962B2 (en) | 2016-07-07 | 2019-10-01 | Cardiac Pacemakers, Inc. | Leadless pacemaker using pressure measurements for pacing capture verification |
US10688304B2 (en) | 2016-07-20 | 2020-06-23 | Cardiac Pacemakers, Inc. | Method and system for utilizing an atrial contraction timing fiducial in a leadless cardiac pacemaker system |
US10797758B2 (en) | 2016-07-22 | 2020-10-06 | Proteus Digital Health, Inc. | Electromagnetic sensing and detection of ingestible event markers |
US10187121B2 (en) | 2016-07-22 | 2019-01-22 | Proteus Digital Health, Inc. | Electromagnetic sensing and detection of ingestible event markers |
US10391319B2 (en) | 2016-08-19 | 2019-08-27 | Cardiac Pacemakers, Inc. | Trans septal implantable medical device |
US10870008B2 (en) | 2016-08-24 | 2020-12-22 | Cardiac Pacemakers, Inc. | Cardiac resynchronization using fusion promotion for timing management |
US10780278B2 (en) | 2016-08-24 | 2020-09-22 | Cardiac Pacemakers, Inc. | Integrated multi-device cardiac resynchronization therapy using P-wave to pace timing |
US11464982B2 (en) | 2016-08-24 | 2022-10-11 | Cardiac Pacemakers, Inc. | Integrated multi-device cardiac resynchronization therapy using p-wave to pace timing |
US10905889B2 (en) | 2016-09-21 | 2021-02-02 | Cardiac Pacemakers, Inc. | Leadless stimulation device with a housing that houses internal components of the leadless stimulation device and functions as the battery case and a terminal of an internal battery |
US10994145B2 (en) | 2016-09-21 | 2021-05-04 | Cardiac Pacemakers, Inc. | Implantable cardiac monitor |
US10758737B2 (en) | 2016-09-21 | 2020-09-01 | Cardiac Pacemakers, Inc. | Using sensor data from an intracardially implanted medical device to influence operation of an extracardially implantable cardioverter |
US11793419B2 (en) | 2016-10-26 | 2023-10-24 | Otsuka Pharmaceutical Co., Ltd. | Methods for manufacturing capsules with ingestible event markers |
US11529071B2 (en) | 2016-10-26 | 2022-12-20 | Otsuka Pharmaceutical Co., Ltd. | Methods for manufacturing capsules with ingestible event markers |
US10758724B2 (en) | 2016-10-27 | 2020-09-01 | Cardiac Pacemakers, Inc. | Implantable medical device delivery system with integrated sensor |
US11305125B2 (en) | 2016-10-27 | 2022-04-19 | Cardiac Pacemakers, Inc. | Implantable medical device with gyroscope |
US10434314B2 (en) | 2016-10-27 | 2019-10-08 | Cardiac Pacemakers, Inc. | Use of a separate device in managing the pace pulse energy of a cardiac pacemaker |
US10765871B2 (en) | 2016-10-27 | 2020-09-08 | Cardiac Pacemakers, Inc. | Implantable medical device with pressure sensor |
US10413733B2 (en) | 2016-10-27 | 2019-09-17 | Cardiac Pacemakers, Inc. | Implantable medical device with gyroscope |
US10561330B2 (en) | 2016-10-27 | 2020-02-18 | Cardiac Pacemakers, Inc. | Implantable medical device having a sense channel with performance adjustment |
US10463305B2 (en) | 2016-10-27 | 2019-11-05 | Cardiac Pacemakers, Inc. | Multi-device cardiac resynchronization therapy with timing enhancements |
US10434317B2 (en) | 2016-10-31 | 2019-10-08 | Cardiac Pacemakers, Inc. | Systems and methods for activity level pacing |
US10617874B2 (en) | 2016-10-31 | 2020-04-14 | Cardiac Pacemakers, Inc. | Systems and methods for activity level pacing |
US10583301B2 (en) | 2016-11-08 | 2020-03-10 | Cardiac Pacemakers, Inc. | Implantable medical device for atrial deployment |
US10632313B2 (en) | 2016-11-09 | 2020-04-28 | Cardiac Pacemakers, Inc. | Systems, devices, and methods for setting cardiac pacing pulse parameters for a cardiac pacing device |
US10894163B2 (en) | 2016-11-21 | 2021-01-19 | Cardiac Pacemakers, Inc. | LCP based predictive timing for cardiac resynchronization |
US10639486B2 (en) | 2016-11-21 | 2020-05-05 | Cardiac Pacemakers, Inc. | Implantable medical device with recharge coil |
US10881869B2 (en) | 2016-11-21 | 2021-01-05 | Cardiac Pacemakers, Inc. | Wireless re-charge of an implantable medical device |
US10881863B2 (en) | 2016-11-21 | 2021-01-05 | Cardiac Pacemakers, Inc. | Leadless cardiac pacemaker with multimode communication |
US11147979B2 (en) | 2016-11-21 | 2021-10-19 | Cardiac Pacemakers, Inc. | Implantable medical device with a magnetically permeable housing and an inductive coil disposed about the housing |
US11207532B2 (en) | 2017-01-04 | 2021-12-28 | Cardiac Pacemakers, Inc. | Dynamic sensing updates using postural input in a multiple device cardiac rhythm management system |
US10029107B1 (en) | 2017-01-26 | 2018-07-24 | Cardiac Pacemakers, Inc. | Leadless device with overmolded components |
US11590353B2 (en) | 2017-01-26 | 2023-02-28 | Cardiac Pacemakers, Inc. | Intra-body device communication with redundant message transmission |
US10835753B2 (en) | 2017-01-26 | 2020-11-17 | Cardiac Pacemakers, Inc. | Intra-body device communication with redundant message transmission |
US10737102B2 (en) | 2017-01-26 | 2020-08-11 | Cardiac Pacemakers, Inc. | Leadless implantable device with detachable fixation |
US10821288B2 (en) | 2017-04-03 | 2020-11-03 | Cardiac Pacemakers, Inc. | Cardiac pacemaker with pacing pulse energy adjustment based on sensed heart rate |
US10905872B2 (en) | 2017-04-03 | 2021-02-02 | Cardiac Pacemakers, Inc. | Implantable medical device with a movable electrode biased toward an extended position |
US11065459B2 (en) | 2017-08-18 | 2021-07-20 | Cardiac Pacemakers, Inc. | Implantable medical device with pressure sensor |
US10918875B2 (en) | 2017-08-18 | 2021-02-16 | Cardiac Pacemakers, Inc. | Implantable medical device with a flux concentrator and a receiving coil disposed about the flux concentrator |
US11235163B2 (en) | 2017-09-20 | 2022-02-01 | Cardiac Pacemakers, Inc. | Implantable medical device with multiple modes of operation |
US11185703B2 (en) | 2017-11-07 | 2021-11-30 | Cardiac Pacemakers, Inc. | Leadless cardiac pacemaker for bundle of his pacing |
US11234280B2 (en) | 2017-11-29 | 2022-01-25 | Samsung Electronics Co., Ltd. | Method for RF communication connection using electronic device and user touch input |
US11235162B2 (en) | 2017-11-29 | 2022-02-01 | Medtronic, Inc. | Tissue conduction communication between devices |
CN111417430A (zh) * | 2017-11-29 | 2020-07-14 | 美敦力公司 | 设备之间的组织传导通信 |
WO2019108787A1 (en) * | 2017-11-29 | 2019-06-06 | Medtronic, Inc. | Tissue conduction communication between devices |
US11052258B2 (en) | 2017-12-01 | 2021-07-06 | Cardiac Pacemakers, Inc. | Methods and systems for detecting atrial contraction timing fiducials within a search window from a ventricularly implanted leadless cardiac pacemaker |
US11260216B2 (en) | 2017-12-01 | 2022-03-01 | Cardiac Pacemakers, Inc. | Methods and systems for detecting atrial contraction timing fiducials during ventricular filling from a ventricularly implanted leadless cardiac pacemaker |
US11071870B2 (en) | 2017-12-01 | 2021-07-27 | Cardiac Pacemakers, Inc. | Methods and systems for detecting atrial contraction timing fiducials and determining a cardiac interval from a ventricularly implanted leadless cardiac pacemaker |
US11813463B2 (en) | 2017-12-01 | 2023-11-14 | Cardiac Pacemakers, Inc. | Leadless cardiac pacemaker with reversionary behavior |
US10874861B2 (en) | 2018-01-04 | 2020-12-29 | Cardiac Pacemakers, Inc. | Dual chamber pacing without beat-to-beat communication |
US11529523B2 (en) | 2018-01-04 | 2022-12-20 | Cardiac Pacemakers, Inc. | Handheld bridge device for providing a communication bridge between an implanted medical device and a smartphone |
US11819699B2 (en) | 2018-03-23 | 2023-11-21 | Medtronic, Inc. | VfA cardiac resynchronization therapy |
US11400296B2 (en) | 2018-03-23 | 2022-08-02 | Medtronic, Inc. | AV synchronous VfA cardiac therapy |
US11058880B2 (en) | 2018-03-23 | 2021-07-13 | Medtronic, Inc. | VFA cardiac therapy for tachycardia |
US11235159B2 (en) | 2018-03-23 | 2022-02-01 | Medtronic, Inc. | VFA cardiac resynchronization therapy |
US11235161B2 (en) | 2018-09-26 | 2022-02-01 | Medtronic, Inc. | Capture in ventricle-from-atrium cardiac therapy |
US11951313B2 (en) | 2018-11-17 | 2024-04-09 | Medtronic, Inc. | VFA delivery systems and methods |
US11679265B2 (en) | 2019-02-14 | 2023-06-20 | Medtronic, Inc. | Lead-in-lead systems and methods for cardiac therapy |
US11697025B2 (en) | 2019-03-29 | 2023-07-11 | Medtronic, Inc. | Cardiac conduction system capture |
US11213676B2 (en) | 2019-04-01 | 2022-01-04 | Medtronic, Inc. | Delivery systems for VfA cardiac therapy |
US11712188B2 (en) | 2019-05-07 | 2023-08-01 | Medtronic, Inc. | Posterior left bundle branch engagement |
US11305127B2 (en) | 2019-08-26 | 2022-04-19 | Medtronic Inc. | VfA delivery and implant region detection |
US11813466B2 (en) | 2020-01-27 | 2023-11-14 | Medtronic, Inc. | Atrioventricular nodal stimulation |
US11911168B2 (en) | 2020-04-03 | 2024-02-27 | Medtronic, Inc. | Cardiac conduction system therapy benefit determination |
US11813464B2 (en) | 2020-07-31 | 2023-11-14 | Medtronic, Inc. | Cardiac conduction system evaluation |
WO2023028164A1 (en) * | 2021-08-24 | 2023-03-02 | Canary Medical Switzerland Ag | Implantable medical device with sensing and communication functionality |
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US20200254268A1 (en) | 2020-08-13 |
CN101926097A (zh) | 2010-12-22 |
US11612321B2 (en) | 2023-03-28 |
ES2661739T3 (es) | 2018-04-03 |
MY154699A (en) | 2015-07-15 |
SG190590A1 (en) | 2013-06-28 |
JP2011505108A (ja) | 2011-02-17 |
DK2215726T3 (en) | 2018-04-09 |
EP2215726A4 (en) | 2012-05-09 |
IL206049A (en) | 2015-03-31 |
JP5794782B2 (ja) | 2015-10-14 |
KR101586193B1 (ko) | 2016-01-18 |
AU2008329620B2 (en) | 2014-05-08 |
AU2016201924A1 (en) | 2016-05-19 |
WO2009070773A1 (en) | 2009-06-04 |
IL206049A0 (en) | 2010-11-30 |
AU2008329620A1 (en) | 2009-06-04 |
EP2215726A1 (en) | 2010-08-11 |
JP2015122811A (ja) | 2015-07-02 |
AU2014203793A1 (en) | 2014-07-31 |
CA2717809A1 (en) | 2009-06-04 |
EP2215726B1 (en) | 2018-01-10 |
CN101926097B (zh) | 2016-10-05 |
KR20100086050A (ko) | 2010-07-29 |
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