US20090020114A1 - Metered dose inhaler actuator - Google Patents

Metered dose inhaler actuator Download PDF

Info

Publication number
US20090020114A1
US20090020114A1 US12/167,508 US16750808A US2009020114A1 US 20090020114 A1 US20090020114 A1 US 20090020114A1 US 16750808 A US16750808 A US 16750808A US 2009020114 A1 US2009020114 A1 US 2009020114A1
Authority
US
United States
Prior art keywords
actuator
sump
metered dose
formulation
dose inhaler
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/167,508
Other languages
English (en)
Inventor
Gaetano Brambilla
Tanya Kathleen Church
David Andrew Lewis
Brian John Meakin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Assigned to CHIESI FARMACEUTICI S.P.A. reassignment CHIESI FARMACEUTICI S.P.A. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LEWIS, DAVID ANDREW, MEAKIN, BRIAN JOHN, BRAMBILLA, GAETANO, CHURCH, TANYA KATHLEEN
Publication of US20090020114A1 publication Critical patent/US20090020114A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Definitions

  • MDIs metered dose inhalers
  • aerosol delivery systems designed to deliver a medicament formulated with a compressed, low boiling point liquid gas propellant.
  • MDIs are designed to meter a predetermined quantity of the medicament, completely dissolved (in solution) or micronised and suspended in the formulation and dispense the dose as an inhalable aerosol cloud.
  • WO 2004/041326 discloses a system having a tubular nozzle with an inlet configured in size to communicate with the metering assembly of the container, and an outlet for directing the medicament to a patient, to allow a potential increase in FPM while minimizing excessive medicament deposition within the system and within the patient's oropharynx.
  • the tubular nozzle which is used in place of conventional nozzle block including sump and nozzle channel, has a defined length and a longitudinal axis that is curvilinear throughout the defined length of the tubular nozzle.
  • FIG. 3 shows an enlargement of the nozzle block within a preferred design of an actuator of the present invention.
  • Each filled canister is conveniently fitted into the actuator of the present invention through which upon actuation a medicament may be delivered from the filled canister via the metering valve to the mouth of a patient.
  • Materials for manufacture of the metering chamber and/or the valve stem may desirably be fluorinated, partially fluorinated or impregnated with fluorine containing substances in order to resist drug deposition.
US12/167,508 2007-07-03 2008-07-03 Metered dose inhaler actuator Abandoned US20090020114A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07012988.7 2007-07-03
EP07012988A EP2011534A1 (en) 2007-07-03 2007-07-03 Metered dose inhaler actuator

Publications (1)

Publication Number Publication Date
US20090020114A1 true US20090020114A1 (en) 2009-01-22

Family

ID=38523441

Family Applications (1)

Application Number Title Priority Date Filing Date
US12/167,508 Abandoned US20090020114A1 (en) 2007-07-03 2008-07-03 Metered dose inhaler actuator

Country Status (11)

Country Link
US (1) US20090020114A1 (ja)
EP (2) EP2011534A1 (ja)
JP (1) JP2010531688A (ja)
KR (1) KR20100052470A (ja)
CN (1) CN101784299A (ja)
AU (1) AU2008271599B2 (ja)
BR (1) BRPI0811786A2 (ja)
CA (1) CA2692370A1 (ja)
EA (1) EA018547B1 (ja)
WO (1) WO2009003657A1 (ja)
ZA (1) ZA200909196B (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130295023A1 (en) * 2009-11-17 2013-11-07 CIPLA Limited, Mumbai, INDA Inhalation Solutions
US20160101244A1 (en) * 2013-05-03 2016-04-14 Chv Pharma Gmbh & Co. Kg Inhaler for a metered dose aerosol
US20180214646A1 (en) * 2017-01-31 2018-08-02 Dunan Microstaq, Inc. Metering Device For A Metered Dose Inhaler
US11426538B2 (en) * 2016-03-31 2022-08-30 Chiesi Farmaceutici S.P.A. Aerosol inhalation device

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2534957B1 (en) 2007-12-14 2015-05-27 AeroDesigns, Inc Delivering aerosolizable products
BR112013001119A2 (pt) * 2010-07-16 2016-05-24 Cipla Ltd composição farmacêutica, processo para fabricar uma composição farmacêutica, uso de r(+)budesonida e um broncodilatador, e método de profilaxia ou tratamento de uma doença respiratória, inflamatória ou obstrutiva das vias aéreas
KR101857834B1 (ko) 2010-09-06 2018-05-14 키에시 파르마슈티시 엣스. 피. 에이. 계량된-투여량 흡입기 액츄에이터, 계량된-투여량 흡입기
SI2627386T1 (sl) * 2010-10-12 2015-10-30 Ivax Pharmaceuticals Ireland Nosna pršilna naprava
CA2827130A1 (en) * 2011-06-27 2013-01-03 Board Of Regents, The University Of Texas System Toroidal pharmaceutical formulations
JP6335798B2 (ja) * 2012-02-28 2018-05-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規噴射剤含有チオトロピウム製剤
MD736Z (ro) * 2013-05-14 2014-09-30 Александру ГУЛПА Inhalator pentru uleiurile eterice
MD1005Z (ro) * 2015-09-28 2016-09-30 Александру ГУЛПА Inhalator
GB2544113B (en) * 2015-11-09 2018-05-23 Aer Beatha Ltd Canister

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5894964A (en) * 1994-09-23 1999-04-20 Chesebrough-Pond's Usa Co., Aerosol
US20030089368A1 (en) * 2000-02-09 2003-05-15 Junguo Zhao Actuator nozzle for metered dose inhaler
US20050061314A1 (en) * 2001-12-21 2005-03-24 Vactura Limited Metered dose inhaler
US20050129621A1 (en) * 2002-03-01 2005-06-16 Chiesi Farmaceutici S.P.A. Aerosol formulations for pulmonary administration of medicaments to produce a systemic effect
US20050172960A1 (en) * 2002-07-19 2005-08-11 The Technology Partnership Plc Inhaler valve mechanism
US20060034776A1 (en) * 2004-08-10 2006-02-16 Boehringer Ingelheim International Gmbh Inhalable medicaments containing a new anticholinergic, corticosteroids, and betamimetics
US20060099149A1 (en) * 2003-05-21 2006-05-11 Karib Kemi-Pharm Limited Metered dose inhaler product
US20070221213A1 (en) * 2006-03-27 2007-09-27 Herbert Wachtel Dosage aerosols for the application of pharmaceutical formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
IT1303788B1 (it) * 1998-11-25 2001-02-23 Chiesi Farma Spa Formulazioni di aerosol medicinali.
JP2005500878A (ja) * 2001-06-26 2005-01-13 ノートン　ヘルスケアー　リミテッド 改良されたエアゾールアクチュエータ
US7255102B2 (en) * 2002-02-01 2007-08-14 Generex Pharmaceuticals Inc. Metered dose spray device for use with macromolecular pharmaceutical agents such as insulin
US6979668B2 (en) * 2002-12-16 2005-12-27 Generex Pharmaceuticals Incorporated Cleaning compound for and method of cleaning valves and actuators of metered dose dispensers containing pharmaceutical compositions
GB0402797D0 (en) * 2004-02-09 2004-03-10 Novartis Ag Organic compounds

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5894964A (en) * 1994-09-23 1999-04-20 Chesebrough-Pond's Usa Co., Aerosol
US20030089368A1 (en) * 2000-02-09 2003-05-15 Junguo Zhao Actuator nozzle for metered dose inhaler
US20050061314A1 (en) * 2001-12-21 2005-03-24 Vactura Limited Metered dose inhaler
US20050129621A1 (en) * 2002-03-01 2005-06-16 Chiesi Farmaceutici S.P.A. Aerosol formulations for pulmonary administration of medicaments to produce a systemic effect
US20050172960A1 (en) * 2002-07-19 2005-08-11 The Technology Partnership Plc Inhaler valve mechanism
US20060099149A1 (en) * 2003-05-21 2006-05-11 Karib Kemi-Pharm Limited Metered dose inhaler product
US20060034776A1 (en) * 2004-08-10 2006-02-16 Boehringer Ingelheim International Gmbh Inhalable medicaments containing a new anticholinergic, corticosteroids, and betamimetics
US20070221213A1 (en) * 2006-03-27 2007-09-27 Herbert Wachtel Dosage aerosols for the application of pharmaceutical formulations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Newman, SP. Principles of Metered-Dose Inhaler Design. Resp. Care 2005. 50(9). 1177-1190. *
Smyth et al. Spray Pattern Analysis for Metered Dose Inhalers: Effect of Actuator Design. Pharm. Res. 23(7), 2006. 1591-1596. *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130295023A1 (en) * 2009-11-17 2013-11-07 CIPLA Limited, Mumbai, INDA Inhalation Solutions
US20160101244A1 (en) * 2013-05-03 2016-04-14 Chv Pharma Gmbh & Co. Kg Inhaler for a metered dose aerosol
US11426538B2 (en) * 2016-03-31 2022-08-30 Chiesi Farmaceutici S.P.A. Aerosol inhalation device
US20180214646A1 (en) * 2017-01-31 2018-08-02 Dunan Microstaq, Inc. Metering Device For A Metered Dose Inhaler
US10556072B2 (en) * 2017-01-31 2020-02-11 Dunan Microstaq, Inc. Metering device for a metered dose inhaler

Also Published As

Publication number Publication date
EP2173420A1 (en) 2010-04-14
AU2008271599B2 (en) 2013-10-10
EP2011534A1 (en) 2009-01-07
EA200901663A1 (ru) 2010-06-30
KR20100052470A (ko) 2010-05-19
BRPI0811786A2 (pt) 2014-11-11
CA2692370A1 (en) 2009-01-08
AU2008271599A1 (en) 2009-01-08
EA018547B1 (ru) 2013-08-30
CN101784299A (zh) 2010-07-21
WO2009003657A1 (en) 2009-01-08
JP2010531688A (ja) 2010-09-30
ZA200909196B (en) 2011-02-23

Similar Documents

Publication Publication Date Title
AU2008271599B2 (en) Metered dose inhaler actuator
CA2477885C (en) Pressurised metered dose inhalers containing solutions of beta-2 agonists
JP6023247B2 (ja) 鼻内噴霧装置
KR101861117B1 (ko) 글리코피로니움 브로마이드 및 포모테롤 조합의 안정한 가압 에어로졸 용액 조성물
CA2649556C (en) Pharmaceutical solution formulations for pressurised metered dose inhalers
US7220403B2 (en) Pharmaceutical formulation of fluticasone propionate
KR101865131B1 (ko) 글리코피로니움 브로마이드 및 포모테롤 조합의 안정한 가압 에어로졸 용액 조성물
CN101502500A (zh) 含有β2-激动剂的溶液的加压计量吸入器
TWI449523B (zh) 福莫特羅（ｆｏｒｍｏｔｅｒｏｌ）及二丙酸倍氯米松（ｂｅｃｌｏｍｅｔａｓｏｎｅ ｄｉｐｒｏｐｉｏｎａｔｅ）之醫藥噴霧劑配方
BR112012015335B1 (pt) formulação de aerossol para doença pulmonar obstrutiva crõnica
US20030178022A1 (en) Pressurized metered dose inhaler (PMDI) actuators and medicinal aerosol solution formulation products comprising therse actuators
GB2385596A (en) Pharmaceutical formulation of fluticasone propionate

Legal Events

Date Code Title Description
AS Assignment

Owner name: CHIESI FARMACEUTICI S.P.A., ITALY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BRAMBILLA, GAETANO;CHURCH, TANYA KATHLEEN;LEWIS, DAVID ANDREW;AND OTHERS;REEL/FRAME:021895/0039;SIGNING DATES FROM 20080905 TO 20080924

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION