US20080294029A1 - System to Measure Blood Coagulation Related Parameters - Google Patents

System to Measure Blood Coagulation Related Parameters Download PDF

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Publication number
US20080294029A1
US20080294029A1 US12/091,953 US9195306A US2008294029A1 US 20080294029 A1 US20080294029 A1 US 20080294029A1 US 9195306 A US9195306 A US 9195306A US 2008294029 A1 US2008294029 A1 US 2008294029A1
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Prior art keywords
channel
blood
layer
expandable
activated
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Abandoned
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US12/091,953
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English (en)
Inventor
Laurent-Dominique Piveteau
Veronique Vallet
Frederic Neftel
Lynda Metref
Nicolas Blanc
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Debiotech SA
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Debiotech SA
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Assigned to DEBIOTECH S.A. reassignment DEBIOTECH S.A. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: METREF, LYNDA, PIVETEAU, LAURENT-DOMINIQUE, VALLET, VERONIQUE, BLANC, NICOLAS, NEFTEL, FREDERIC
Publication of US20080294029A1 publication Critical patent/US20080294029A1/en
Abandoned legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0026—Valves using channel deformation
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
    • F16K99/004—Operating means specially adapted for microvalves operated by temperature variations using radiation
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0061—Operating means specially adapted for microvalves actuated by fluids actuated by an expanding gas or liquid volume
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0672—Swellable plugs
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0086—Medical applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/218—Means to regulate or vary operation of device
    • Y10T137/2191—By non-fluid energy field affecting input [e.g., transducer]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/218—Means to regulate or vary operation of device
    • Y10T137/2191—By non-fluid energy field affecting input [e.g., transducer]
    • Y10T137/2196—Acoustical or thermal energy

Definitions

  • the invention relates to portable devices and methods for measuring coagulation time, such as for example prothrombin time or activated partial thromboplastine time.
  • Heparin is administrated subcutaneously or intravenously. Heparin activates a plasmatic protein, the antithrombin III that is a natural inhibitor of protease implicated in the coagulation cascade (factors VIIa, XIa, IXa, Xa, IIa). The rate of inactivation of these proteases by AT-III increases 1000-fold due to the binding of heparin.
  • Warfarin decrease blood coagulation by interfering with vitamin K metabolism by inhibiting the effective synthesis of biologically active forms of the Vitamin-K-dependent clotting factors II, VII, IX and X, as well as the regulatory factors protein C, protein S and protein Z. Warfarin has the advantage that it may be taken orally. However dosing warfarin is complicated by the fact that it is known to interact with many commonly used medications and other chemicals that may be present in appreciable quantities in food. But with both medications, dangerous side effects such as bleeding exist. Therefore in order to optimize the therapeutic effect and minimize risks for the patient, close monitoring of the degree of anticoagulation is required by blood testing. Two coagulation test measures are routinely used: the prothrombin time and the activated partial thromboplastin time.
  • the present invention simultaneously concerns an alternative and an improvement with respect to state-of-the-art coagulometers.
  • a system to measure blood coagulation related parameters comprising one first channel adapted to contain a blood sample, the system containing, at least partially, an expandable material which is able to increase its volume when activated by an exciting source, said system furthermore comprising several excitable regions distributed close to said first channel, in such a way that, when one of said excitable region is activated, said expandable material increases to such an extend that the channel cross section is reduced at a location situated at or near to said excitable region.
  • the invention furthermore relates to the use of a system to measure blood coagulation related parameters as defined above.
  • the coagulation time is based on the distance made by the liquid along the channel before being stopped, said liquid being moved by a sequential activation of the exciting elements.
  • the inventive concept is based on the measurement of the displacement of blood along a channel.
  • the displacement is driven by the closing of a channel located in a material that can change its volume when activated by an exciting factor.
  • the device includes a permanent and a disposable part.
  • the disposable part is in contact with blood and contains the channel in which the blood will move.
  • the permanent part contains an electronic that will trigger the activation of the material and measure the displacement. It also contains a screen to read the result of the test.
  • expansible material will be described as PDMSXB, i.e. Expancel beads dispersed into a PDMS matrix, and activation mean as heat produced by the resistance of an electric circuit. Naturally this description can apply to any material having the property to change its volume when activated by an exciting factor.
  • FIG. 1 is an illustration of the entire device (permanent +disposable part)
  • FIG. 2 is a side view of disposable part with the channel molded in the PDMS layer
  • FIG. 3 is a side view of disposable part with the channel molded in the PDMSXB layer
  • FIG. 4 is a top view of the disposable part
  • FIG. 5 is a detailed view of a resistance
  • FIG. 6 is an illustration of the functioning of the device from a front view
  • FIG. 7 is an illustration of the functioning of the device from a side view
  • FIG. 8 is an illustration of the functioning of the device with a non miscible fluid pushing the blood, from a side view
  • the disposable part 12 is formed by the superposition of the following layers: a PCB layer 1 , a PDMS layer 2 , a PDMSXB layer 4 , a protective layer 4 and a cover layer 5 .
  • the resistances 9 producing heat to activate the material are printed on the PCBlayer 1 .
  • the channel network in which the blood is displaced is molded in the POMS or in the PDMSXB layer.
  • the protective layer is preferably biocompatible with blood and/or ensure thermal isolation of the blood against the heated material.
  • the protective layer can consist of the superposition of two layers, one ensuring thermal isolation and the other biocompatibility.
  • the protective layer covering the PDMS and the one covering the PDMSXB are not necessarily the same.
  • the cover layer closes the channel but preferably contain an inlet hole that connect the channel to the outside in order to let the blood enter the device and an outlet hole
  • the disposable part is preferably adapted to the sensing mean incorporated to the permanent part, for example, if optical mean is used, the disposable is preferably transparent to the light used by, for example, containing a window.
  • the channel network preferably has the following properties:
  • the channel network may also have the following properties:
  • the resistance printed on the PCB preferably has the following properties:
  • sample of blood is taken from the patient, for example with a lancet.
  • the sample is placed on the cover hole and is aspired inside the device by capillary forces or by a pumping mechanism (FIGS. 6 . b & 7 . a ).
  • the sample of blood fills the different channel until their narrowing where it is stopped due to change in fluidic resistance. At this stage, it may be mixed with chemical reactive needed to perform the test.
  • the resistances placed upstream the narrowing are heated and this part of the channels is progressively closed and a volume of blood corresponding to the size of the resistance is push forward in the channel (FIGS. 6 . c & 7 . b ). This allows controlling the volume of blood to be analyzed.
  • the resistances are then heated one after the other along a channel, with a controlled amount of time between each successive heating (FIGS. 6 . d - e & 7 . c ).
  • the resistances are heated simultaneously along the different channels, in order to compare the coagulation time in the different channel, i.e. the coagulation time of blood mixed with different chemical. As long as blood has not coagulated, it may be push forward by the closing of the channel, but once coagulated it stays in place and the channel may not be closed (FIGS. 6 . f & 7 . d ).
  • Coagulation time is calculated by determining, for example optically, where the clot stays and at what time the corresponding resistance was heated.
  • Another fluid that is non miscible with blood may be placed upstream of the blood in the channel.
  • This other fluid is therefore the one that is displaced by the closing of the channel, and its displacement induces blood displacement ( FIG. 8 ).

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Micromachines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Materials For Medical Uses (AREA)
US12/091,953 2005-11-25 2006-11-24 System to Measure Blood Coagulation Related Parameters Abandoned US20080294029A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20050111343 EP1790861A1 (fr) 2005-11-25 2005-11-25 Système microfluidique
EP05111343.9 2005-11-25
PCT/IB2006/054432 WO2007060635A2 (fr) 2005-11-25 2006-11-24 Système pour mesurer des paramètres rattachés à la coagulation du sang

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US20080294029A1 true US20080294029A1 (en) 2008-11-27

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US12/092,446 Expired - Fee Related US8506906B2 (en) 2005-11-25 2006-11-24 Microfluidic device
US12/091,953 Abandoned US20080294029A1 (en) 2005-11-25 2006-11-24 System to Measure Blood Coagulation Related Parameters

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US (2) US8506906B2 (fr)
EP (3) EP1790861A1 (fr)
JP (2) JP5032493B2 (fr)
CN (2) CN101356378B (fr)
WO (2) WO2007060636A2 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048020A1 (fr) * 2008-10-20 2010-04-29 Epitome Pharmaceuticals Limited Procédés et systèmes améliorant l'intervention pharmaceutique dans le contrôle de la coagulation
US20120064552A1 (en) * 2010-09-14 2012-03-15 California Institute Of Technology Using blood clot in microfluidic valving applications
CN104062207A (zh) * 2014-07-15 2014-09-24 中国科学院苏州生物医学工程技术研究所 一种血液粘弹力监测装置
WO2016122559A1 (fr) * 2015-01-30 2016-08-04 Hewlett-Packard Development Company, L.P. Puce microfluidique pour la détection de la coagulation
US9649436B2 (en) 2011-09-21 2017-05-16 Bayer Healthcare Llc Assembly method for a fluid pump device for a continuous multi-fluid delivery system
US10507319B2 (en) 2015-01-09 2019-12-17 Bayer Healthcare Llc Multiple fluid delivery system with multi-use disposable set and features thereof
US11112400B2 (en) 2016-01-16 2021-09-07 Hewlett-Packard Development Company, L.P. Blood characteristic measurement
US12019041B2 (en) 2018-11-20 2024-06-25 Xatek, Inc. Portable dielectric spectroscopy device

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2901489A1 (fr) * 2006-05-29 2007-11-30 Debiotech Sa Dispositif microfluidique avec materiau de volume variable
EP2208530A1 (fr) * 2008-12-23 2010-07-21 Debiotech S.A. Système micropompe en puce
DE102009035291B4 (de) * 2009-07-30 2011-09-01 Karlsruher Institut für Technologie Vorrichtung zur Erzeugung einer mikrofluidischen Kanalstruktur in einer Kammer, Verfahren zu ihrer Herstellung und ihre Verwendung
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CN101356378A (zh) 2009-01-28
EP1954950A2 (fr) 2008-08-13
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WO2007060635A2 (fr) 2007-05-31
EP1790861A1 (fr) 2007-05-30
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JP5032493B2 (ja) 2012-09-26
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US20090044875A1 (en) 2009-02-19
CN101317011A (zh) 2008-12-03

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