US20060251624A1 - Cells exhibiting neuronal cell progenitor characteristics and methods of making them - Google Patents

Cells exhibiting neuronal cell progenitor characteristics and methods of making them Download PDF

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Publication number
US20060251624A1
US20060251624A1 US11/100,664 US10066405A US2006251624A1 US 20060251624 A1 US20060251624 A1 US 20060251624A1 US 10066405 A US10066405 A US 10066405A US 2006251624 A1 US2006251624 A1 US 2006251624A1
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Prior art keywords
cells
stem cells
adherent stem
marrow adherent
inhibitors
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Abandoned
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US11/100,664
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English (en)
Inventor
Mari Dezawa
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Sanbio Inc
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Sanbio Inc
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Application filed by Sanbio Inc filed Critical Sanbio Inc
Priority to US11/100,664 priority Critical patent/US20060251624A1/en
Assigned to SANBIO INC. reassignment SANBIO INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DEZAWA, MARI
Publication of US20060251624A1 publication Critical patent/US20060251624A1/en
Assigned to SANBIO, INC. reassignment SANBIO, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DEZAWA, MARI
Priority to US12/583,782 priority patent/US20090324561A1/en
Assigned to VENTURE LENDING & LEASING IV, INC., VENTURE LENDING & LEASING V, INC. reassignment VENTURE LENDING & LEASING IV, INC. SECURITY AGREEMENT Assignors: SANBIO, INC.
Assigned to SANBIO, INC. reassignment SANBIO, INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: VENTURE LENDING & LEASING IV, INC., VENTURE LENDING & LEASING V, INC.
Priority to US13/068,888 priority patent/US20110229442A1/en
Priority to US13/672,341 priority patent/US20130071924A1/en
Priority to US14/735,005 priority patent/US9441199B2/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
US11/100,664 2004-04-12 2005-04-07 Cells exhibiting neuronal cell progenitor characteristics and methods of making them Abandoned US20060251624A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US11/100,664 US20060251624A1 (en) 2004-04-12 2005-04-07 Cells exhibiting neuronal cell progenitor characteristics and methods of making them
US12/583,782 US20090324561A1 (en) 2004-04-12 2009-08-26 Cells exhibiting neuronal progenitor cell characteristics and methods of making them
US13/068,888 US20110229442A1 (en) 2004-04-12 2011-05-23 Cells exhibiting neuronal progenitor cell characteristics and methods of making them
US13/672,341 US20130071924A1 (en) 2004-04-12 2012-11-08 Cells exhibiting neuronal progenitor cell characteristics and methods of making them
US14/735,005 US9441199B2 (en) 2004-04-12 2015-06-09 Cells exhibiting neuronal progenitor cell characteristics and methods of making them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56161304P 2004-04-12 2004-04-12
US11/100,664 US20060251624A1 (en) 2004-04-12 2005-04-07 Cells exhibiting neuronal cell progenitor characteristics and methods of making them

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/583,782 Division US20090324561A1 (en) 2004-04-12 2009-08-26 Cells exhibiting neuronal progenitor cell characteristics and methods of making them
US13/068,888 Continuation US20110229442A1 (en) 2004-04-12 2011-05-23 Cells exhibiting neuronal progenitor cell characteristics and methods of making them

Publications (1)

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US20060251624A1 true US20060251624A1 (en) 2006-11-09

Family

ID=35150551

Family Applications (5)

Application Number Title Priority Date Filing Date
US11/100,664 Abandoned US20060251624A1 (en) 2004-04-12 2005-04-07 Cells exhibiting neuronal cell progenitor characteristics and methods of making them
US12/583,782 Abandoned US20090324561A1 (en) 2004-04-12 2009-08-26 Cells exhibiting neuronal progenitor cell characteristics and methods of making them
US13/068,888 Abandoned US20110229442A1 (en) 2004-04-12 2011-05-23 Cells exhibiting neuronal progenitor cell characteristics and methods of making them
US13/672,341 Abandoned US20130071924A1 (en) 2004-04-12 2012-11-08 Cells exhibiting neuronal progenitor cell characteristics and methods of making them
US14/735,005 Active US9441199B2 (en) 2004-04-12 2015-06-09 Cells exhibiting neuronal progenitor cell characteristics and methods of making them

Family Applications After (4)

Application Number Title Priority Date Filing Date
US12/583,782 Abandoned US20090324561A1 (en) 2004-04-12 2009-08-26 Cells exhibiting neuronal progenitor cell characteristics and methods of making them
US13/068,888 Abandoned US20110229442A1 (en) 2004-04-12 2011-05-23 Cells exhibiting neuronal progenitor cell characteristics and methods of making them
US13/672,341 Abandoned US20130071924A1 (en) 2004-04-12 2012-11-08 Cells exhibiting neuronal progenitor cell characteristics and methods of making them
US14/735,005 Active US9441199B2 (en) 2004-04-12 2015-06-09 Cells exhibiting neuronal progenitor cell characteristics and methods of making them

Country Status (13)

Country Link
US (5) US20060251624A1 (pl)
EP (2) EP2314674A1 (pl)
JP (2) JP2007532112A (pl)
KR (2) KR20130062359A (pl)
CN (1) CN1973031B (pl)
AT (1) ATE523587T1 (pl)
AU (1) AU2005233582B2 (pl)
CA (2) CA2929754A1 (pl)
DK (1) DK1737950T3 (pl)
ES (1) ES2372501T3 (pl)
PL (1) PL1737950T3 (pl)
PT (1) PT1737950E (pl)
WO (1) WO2005100552A2 (pl)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060216276A1 (en) * 2005-03-07 2006-09-28 Mari Dezawa Use of materials for treatment of central nervous system lesions
WO2009073180A2 (en) 2007-12-03 2009-06-11 Sanbio, Inc. Methods and compositions for modulating differentiation of pluripotential cells
US20100196326A1 (en) * 2004-10-22 2010-08-05 Kiminobu Sugaya Method and system for biasing cellular development
US20100266554A1 (en) * 2007-08-15 2010-10-21 Keita Mori Methods and composition for treating neural degeneration
US20100310529A1 (en) * 2007-12-03 2010-12-09 Irina Aizman Extracellular matrix from pluripotent cells
US10245286B2 (en) 2012-01-27 2019-04-02 Sanbio, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
EP3498824A1 (en) 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005233582B2 (en) * 2004-04-12 2009-01-29 Sanbio, Inc. Cells exhibiting neuronal progenitor cell characteristics
CA2667582A1 (en) * 2006-10-27 2008-05-02 The University Of Western Ontario Method of treating conditions associated with proteoglycan production
ES2594229T3 (es) 2008-04-30 2016-12-16 Sanbio, Inc. Células de regeneración nerviosa con alteraciones en la metilación del ADN
JP5932970B2 (ja) 2011-04-06 2016-06-08 サンバイオ，インコーポレイティド 末梢免疫機能を調節するための方法及び組成物
CN104519891B (zh) 2012-05-16 2019-03-22 桑比欧公司 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物
US9326999B2 (en) 2012-10-09 2016-05-03 Sanbio, Inc. Methods and compositions for treatment of retinal degeneration
EP3277297B1 (en) 2015-04-01 2021-07-28 SanBio, Inc. Methods and compositions for stimulation of cell proliferation and provision of biologically active mixtures of fgf2 isoforms
CA3030866A1 (en) 2016-07-21 2018-01-25 Sanbio, Inc. Msc growth predictor assays
CA3047329A1 (en) 2016-12-28 2018-07-05 Sanbio, Inc. Cell delivery system and methods of operation thereof

Citations (3)

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US20010044122A1 (en) * 1999-02-12 2001-11-22 Buck David W. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US7229827B2 (en) * 2001-04-19 2007-06-12 Fcb-Pharmicell Co., Ltd. Method for differentiating mesenchymal stem cells into neural cells

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JPH031260A (ja) 1989-05-30 1991-01-07 Hitachi Ltd 計算機方式
US6653134B2 (en) 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
US6395205B1 (en) * 1996-07-17 2002-05-28 Chemical Lime Company Method of manufacturing an aerated autoclaved concrete material
ES2246085T3 (es) 1998-05-07 2006-02-01 University Of South Florida Celulas de medula osea como fuente de neuronas util para reparar la medula espinal y el cerebro.
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
WO2001046384A2 (en) 1999-12-23 2001-06-28 Cornell Research Foundation, Inc. A method for isolating and purifying multipotential neural progenitor cells and multipotential neural progenitor cells
WO2001052892A2 (en) * 2000-01-24 2001-07-26 Genzyme Corporation Jak/stat pathway inhibitors and the uses thereof
US20040052762A1 (en) * 2001-09-10 2004-03-18 Hua Yu Stat3 agonists and antagonists and therapeutic uses thereof
US20030003090A1 (en) 2001-05-31 2003-01-02 Prockop Darwin J. Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
WO2003014317A2 (en) * 2001-08-08 2003-02-20 Celmed Biosciences Usa Compositions and methods for isolation, propagation, and differentiation of human stem cells and uses thereof
US7682825B2 (en) * 2002-02-06 2010-03-23 Sanbio, Inc. Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene
US20040062753A1 (en) * 2002-09-27 2004-04-01 Alireza Rezania Composite scaffolds seeded with mammalian cells
AU2005233582B2 (en) * 2004-04-12 2009-01-29 Sanbio, Inc. Cells exhibiting neuronal progenitor cell characteristics

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US20010044122A1 (en) * 1999-02-12 2001-11-22 Buck David W. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US7229827B2 (en) * 2001-04-19 2007-06-12 Fcb-Pharmicell Co., Ltd. Method for differentiating mesenchymal stem cells into neural cells

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100196326A1 (en) * 2004-10-22 2010-08-05 Kiminobu Sugaya Method and system for biasing cellular development
US8092792B2 (en) 2005-03-07 2012-01-10 Sanbio, Inc. Use of materials for treatment of central nervous system lesions
US20060216276A1 (en) * 2005-03-07 2006-09-28 Mari Dezawa Use of materials for treatment of central nervous system lesions
US8945919B2 (en) 2007-08-15 2015-02-03 San Bio, Inc. Methods and composition for treating neural degeneration
US20100266554A1 (en) * 2007-08-15 2010-10-21 Keita Mori Methods and composition for treating neural degeneration
EP2985341A2 (en) 2007-12-03 2016-02-17 SanBio, Inc. Methods and compositions for modulating differentiation of pluripotential cells
US20100310529A1 (en) * 2007-12-03 2010-12-09 Irina Aizman Extracellular matrix from pluripotent cells
WO2009073180A3 (en) * 2007-12-03 2009-10-15 Sanbio, Inc. Methods and compositions for modulating differentiation of pluripotential cells
WO2009073180A2 (en) 2007-12-03 2009-06-11 Sanbio, Inc. Methods and compositions for modulating differentiation of pluripotential cells
US10471102B2 (en) 2007-12-03 2019-11-12 Sanbio, Inc. Extracellular matrix from pluripotent cells
US10653724B2 (en) 2007-12-03 2020-05-19 Sanbio, Inc. Extracellular matrix from pluripotent cells
US10702554B2 (en) 2007-12-03 2020-07-07 Sanbio, Inc. Extracellular matrix from pluripotent cells
EP3696261A1 (en) 2007-12-03 2020-08-19 SanBio, Inc. Methods and compositions for modulating differentiation of pluripotential cells
US10245286B2 (en) 2012-01-27 2019-04-02 Sanbio, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
US11304982B2 (en) 2012-01-27 2022-04-19 Atricure, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
EP3498824A1 (en) 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells

Also Published As

Publication number Publication date
CA2929754A1 (en) 2005-10-27
JP5756039B2 (ja) 2015-07-29
US20150267169A1 (en) 2015-09-24
KR20070015542A (ko) 2007-02-05
CN1973031B (zh) 2011-11-02
ATE523587T1 (de) 2011-09-15
DK1737950T3 (da) 2011-12-05
JP2012130348A (ja) 2012-07-12
EP1737950B9 (en) 2012-04-18
AU2005233582B2 (en) 2009-01-29
US20090324561A1 (en) 2009-12-31
CA2562198A1 (en) 2005-10-27
AU2005233582A1 (en) 2005-10-27
PT1737950E (pt) 2011-12-22
WO2005100552A2 (en) 2005-10-27
KR20130062359A (ko) 2013-06-12
US20130071924A1 (en) 2013-03-21
ES2372501T3 (es) 2012-01-20
KR101277310B1 (ko) 2013-06-25
CN1973031A (zh) 2007-05-30
WO2005100552A3 (en) 2006-10-12
PL1737950T3 (pl) 2012-02-29
EP1737950A2 (en) 2007-01-03
EP2314674A1 (en) 2011-04-27
EP1737950B1 (en) 2011-09-07
JP2007532112A (ja) 2007-11-15
US9441199B2 (en) 2016-09-13
CA2562198C (en) 2017-05-30
US20110229442A1 (en) 2011-09-22

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Effective date: 20110208

STCB Information on status: application discontinuation

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