US20060133950A1 - Method and device for disinfecting a microtome cryostat - Google Patents
Method and device for disinfecting a microtome cryostat Download PDFInfo
- Publication number
- US20060133950A1 US20060133950A1 US10/543,195 US54319505A US2006133950A1 US 20060133950 A1 US20060133950 A1 US 20060133950A1 US 54319505 A US54319505 A US 54319505A US 2006133950 A1 US2006133950 A1 US 2006133950A1
- Authority
- US
- United States
- Prior art keywords
- disinfectant
- cryostat
- microtome
- refrigerator
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 30
- 230000000249 desinfective effect Effects 0.000 title claims abstract description 10
- 238000010257 thawing Methods 0.000 claims abstract description 16
- 239000000645 desinfectant Substances 0.000 claims description 74
- 238000010438 heat treatment Methods 0.000 claims description 23
- 238000001816 cooling Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 14
- 238000002604 ultrasonography Methods 0.000 claims description 7
- 239000002699 waste material Substances 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 3
- 230000008016 vaporization Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 16
- 238000001035 drying Methods 0.000 abstract description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 4
- 239000006200 vaporizer Substances 0.000 description 4
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 3
- 239000002826 coolant Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 241000078511 Microtome Species 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 238000007664 blowing Methods 0.000 description 2
- 238000005202 decontamination Methods 0.000 description 2
- 230000003588 decontaminative effect Effects 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
Definitions
- the invention concerns a method for disinfecting a microtome cryostat, comprising a defrosting phase, provision of a vaporous disinfectant which acts upon the closed cryostat chamber, and a period of time during which the disinfectant is effective.
- the invention also concerns a device for disinfecting a microtome cryostat, comprising a microtome in a cryostat chamber, a refrigerator, a means for providing a vaporous disinfectant, and a disinfectant control means to set an effective time after a defrosting phase.
- Disinfection is necessary to protect the operating personnel since microtomes are used for cutting tissue samples which are often infected with germs. Spraying is problematic, in particular, for cryostat microtomes, since the moisture must be removed from the cryostat chamber. Residual moisture on a cryostat microtome freezes after refrigeration for the next working step. Guidances etc. may thereby freeze with the consequence that the microtome is inoperable, or liquid disinfectant, e.g. a highly concentrated alcohol solution, remains in the chamber and causes further problems, even danger of explosion.
- liquid disinfectant e.g. a highly concentrated alcohol solution
- US 2002/0139124 A1 proposes a solution to this problem by disinfection with ozone.
- This is, however, disadvantageous, since ozone is highly corrosive and damages the surfaces via oxidation.
- a further disadvantage is that residual ozone is difficult to remove, is poisonous and highly inflammable, and can partially escape from the device even during the disinfecting phase, which could endanger the operating personnel.
- the company leaflet “AS 600 Cryotome” proposes another solution for decontamination using UV radiation.
- the UV radiation does not reach the shadow regions.
- the UV radiation cannot penetrate deeply enough into cutting waste or sample residues nor into microscopically small depressions in metal surfaces. This method of decontamination is therefore unsatisfactory.
- This object is achieved in accordance with the inventive method in that a temperature difference is generated in the cryostat chamber after the effective time and disinfectant deposited in the colder region is discharged.
- control is designed to generate a temperature difference in the cryostat chamber after the effective time through heating and/or cooling, and a collecting device is disposed in the colder region to remove deposited disinfectant.
- disinfectant and moisture deposit in a colder region after disinfection and are discharged from there in a controlled manner, thereby permitting fast drying and rapid renewed operation while subjecting critical regions of the device, such as the microtome, to particularly effective drying by heating instead of cooling them.
- critical regions of the device such as the microtome
- the device is ready for reliable reuse within a short time after disinfection.
- the most different means can be used as disinfectant, mainly in the form of aqueous solutions, e.g. glutaraldehyde, benzalconium chloride, formalin and didecyl dimethyl ammonium chloride.
- aqueous solutions e.g. glutaraldehyde, benzalconium chloride, formalin and didecyl dimethyl ammonium chloride.
- the temperature difference can be generated both by cooling as well as by heating of a region. It is thereby advantageous to use existing cooling or heating devices.
- the temperature of the refrigerator of the cryostat may be reduced below 0° C. in a cooling phase after the effective time until at least the majority of the disinfectant has deposited on the refrigerator followed by defrosting of the refrigerator to discharge the disinfectant from the cryostat chamber using a collecting device.
- a collecting device of this type is usually disposed below the refrigerator to be able to remove the defrosted dew or defrosted ice liquids from the cryostat chamber.
- Another possibility is to heat the microtome after the effective time. Due to such heating, the disinfectant, e.g. the disinfecting solution, is transferred from the microtome to colder parts of the device with the result that the microtome is dried for the subsequent cooling phase.
- the temperature difference can, of course, be obtained through cooling as well as heating, wherein a combination of the two above-mentioned measures is preferred.
- the colder regions within the cryostat chamber are preferably selected such that the deposited disinfectant or moisture can be easily collected and discharged.
- the heating temperature is preferably considerably higher than the surrounding temperature of the cryostat in order to completely dry the microtome.
- the invention proposes blowing the vaporous disinfectant into the cryostat chamber.
- This forced convection causes uniform wetting of all components.
- the disinfectant can be vaporized through a heater, wherein vaporization is preferably effected through ultrasound which permits generation of a uniform aerosol without separating the phases of the substances of the disinfectant, thereby providing uniform disinfection.
- the disinfectant may, of course, also be present in the form of vapor.
- the cryostat is preferably heated after the defrosting phase to at least the surrounding temperature. This heating is preferably followed by a temperature balancing time to ensure that all components have the same temperature and are subjected to uniform disinfection during the effective time of the disinfectant. Different heaters may be used for heating, wherein a heater installed in the microtome is preferred. Heating via the microtome prevents thawing thereof and thereby dilution of the solvent during the actual subsequent disinfection during the effective time, which provides excellent disinfection of the microtome.
- the cutting waste should be mechanically removed before introduction of the vaporous disinfectant. This may be effected manually or the cutting waste may be suctioned to thereby prevent residual contamination in the cryostat chamber by the cutting waste.
- vaporous disinfectant may be suctioned into a suction system for disinfection thereof.
- Suctioning disinfects tubes, filters, pump and blocking devices of the suction system.
- control is designed to reduce the temperature of the refrigerator of the cryostat below 0° C. in a cooling phase after the effective time until at least the majority of the disinfectant has deposited on the refrigerator, and the refrigerator is subsequently thawed to discharge the disinfectant from the cryostat chamber using the collecting means.
- the microtome may comprise a heater and the control may be designed to initiate heating of the microtome after the effective time thereby completely drying the microtome as already described in connection with the method.
- the refrigerator also advantageously comprises a heater with the control being designed to switch on the heater to accelerate thawing.
- the disinfectant and moisture sublimated on the refrigerator can thereby be easily liquefied and discharged, ensuring rapid reoperation of the device.
- the means for providing a vaporous disinfectant preferably comprises a blower for introducing the vaporous disinfectant into the cryostat chamber to achieve forced convection into the cryostat chamber with uniform distribution of the disinfectant.
- the means for vaporizing the disinfectant is preferably provided with an ultrasound actuator to realize the above-mentioned atomization of the disinfectant without phase separation.
- the means for generating the vaporous disinfectant is preferably supplied with disinfectant from a supply container.
- a valve may be provided to control the liquid level of the disinfectant in the means for generating the vaporous disinfectant.
- FIG. 1 shows an exemplary view of the temperature dependences and method steps of an inventive method
- FIG. 2 shows an embodiment of an inventive microtome cryostat.
- FIG. 1 shows examples of possible temperature dependences of the inventive method, wherein the temperatures T in ° C. are plotted against time t and possible method steps 11 through 19 are shown.
- a defrosting phase 11 is initiated with heating 12 to at least the surrounding temperature T U which is within a range from 20 to 25° C.
- This process is preferably accelerated by operating the heater 7 of the microtome 6 , wherein heating via the microtome 6 is advantageous in that the latter does not thaw. For this reason, the disinfectant 2 cannot be diluted by the dew during subsequent disinfection.
- FIG. 2 In view of the device features, reference is made to FIG. 2 .
- the temperature T M of the microtome 6 increases faster than the temperature T K of the cryostat chamber 3 .
- Heating 12 is therefore preferably followed by a temperature balancing time 12 ′.
- a vaporous disinfectant 2 is provided 13 which is blown into the cryostat chamber 3 .
- the microtome heater 7 When all components have been uniformly wetted with disinfectant 2 , heating 15 of the microtome 6 by the microtome heater 7 is initiated after lapse of an effective time 14 , thereby further increasing the temperature T M of the microtome 6 , e.g. to 50° C. to transfer moisture and disinfectant from the microtome 6 to the colder parts of the cryostat chamber 3 .
- T M the temperature of the microtome 6
- the cryostat 1 is cooled below 0° C. in a cooling phase 16 , preferably to a region of ⁇ 10° C.
- Temperature differences ⁇ T 1 and ⁇ T 2 are thereby generated, wherein ⁇ T 1 is the difference between the temperature T M of the microtome 6 and of the temperature T V of the refrigerator 4 , and ⁇ T 2 is the difference between the temperature T K of the cryostat chamber 3 and the temperature T V of the refrigerator 4 .
- ⁇ T 1 is the difference between the temperature T M of the microtome 6 and of the temperature T V of the refrigerator 4
- ⁇ T 2 is the difference between the temperature T K of the cryostat chamber 3 and the temperature T V of the refrigerator 4 .
- a defrosting phase 17 of the refrigerator 4 is then initiated during which the thawed liquid is discharged.
- the thawed liquid is discharged 18 using a collecting device 5 which guides the thawed liquid out of the cryostat chamber 3 .
- Thawing 17 of the refrigerator 4 is suitably supported by a heater 10 of the refrigerator 4 , wherein the latter is heated e.g. to +6° C.
- the cryostat chamber 3 and, in particular, the microtome 6 are dry. Cooling can be repeated for reoperation 19 to bring the microtome cryostat 1 again to its operating temperature for new object processing.
- FIG. 2 shows an embodiment of an inventive microtome cryostat 1 .
- the microtome cryostat 1 consists of a cooled housing which surrounds a cryostat chamber 3 and can be opened via an opening 32 .
- the cryostat chamber 3 contains a microtome 6 including an object carrier 33 and a knife 34 for producing the cuts.
- the cryostat chamber 3 is cooled using a refrigerator 4 , e.g. a vaporizer, which is connected to a coolant supply 30 .
- the microtome 6 as well as the refrigerator 4 are provided with heaters 7 and 10 to provide rapid thawing and heating.
- a collecting means 5 is provided below the refrigerator 4 which is designed e.g. as drip pan which discharges thawed liquid from the cryostat chamber 3 into a supply container 28 via an outlet 25 .
- a means 8 for providing a vaporous disinfectant 2 blows the evaporated disinfectant 2 via a pipe into the cryostat chamber 3 in the direction of the arrows 35 .
- a blower 20 and an ultrasound actuator 21 are provided to generate the aerosol from the liquid disinfectant 2 .
- a supply container 22 and a valve 23 thereby ensure that the liquid level 24 of the disinfectant 2 in the means 8 is always maintained.
- the invention also comprises a control 9 which is connected to the heater 7 of the microtome 6 , to the heater 10 of the refrigerator 4 , to the ultrasound actuator 21 , the blower 20 and the coolant supply 30 of the refrigerator 4 via connecting lines 31 .
- the control 9 may furthermore be connected to sensors (not shown) for detecting the temperature, air moisture, etc. to ensure effective control of the described temperatures and drying processes. Connection to a ventilator 29 of a suction system 26 and to a valve 23 and further functional elements is also possible.
- the connecting lines 31 provide control 9 of the temperature dependences T K , T M and T V ( FIG. 1 ) and of the method steps 11 through 19 by controlling the heaters 7 and/or 10 and cooling using the refrigerator 4 .
- the control 19 also controls the supply 13 of the vaporous disinfectant 2 via the means 8 .
- the control 9 can also initiate suctioning of vaporous disinfectant 2 into the suction system 26 for disinfecting e.g. the ventilator 29 , the pipes and the filter 27 located therein.
- the illustrated temperature dependences T K , T M and T V and working steps 11 through 19 of FIG. 1 and the device features of FIG. 2 are only examples.
- the temperature differences ⁇ T 1 and ⁇ T 2 for the deposit of disinfectant 2 and moisture and the discharge thereof are essential.
- An alternative design of the heaters or alternative generation of temperature differences within the cryostat chamber 3 are also possible, e.g. only through heating or only through cooling, or the time sequence may be different, wherein e.g. method steps 11 through 19 could partially overlap.
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/078,580 US8246905B2 (en) | 2003-02-01 | 2008-04-02 | Method for disinfecting a microtome cryostat |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10303989A DE10303989B4 (de) | 2003-02-01 | 2003-02-01 | Verfahren und Vorrichtung zur Desinfektion eines Mikrotom-Kryostaten |
DE10303989.9 | 2003-02-01 | ||
PCT/EP2003/013267 WO2004067047A2 (de) | 2003-02-01 | 2003-11-26 | Verfahren und vorrichtung zur desinfektion eines mikrotom-kryostaten |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/013267 A-371-Of-International WO2004067047A2 (de) | 2003-02-01 | 2003-11-26 | Verfahren und vorrichtung zur desinfektion eines mikrotom-kryostaten |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/078,580 Continuation US8246905B2 (en) | 2003-02-01 | 2008-04-02 | Method for disinfecting a microtome cryostat |
Publications (1)
Publication Number | Publication Date |
---|---|
US20060133950A1 true US20060133950A1 (en) | 2006-06-22 |
Family
ID=32747522
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/543,195 Abandoned US20060133950A1 (en) | 2003-02-01 | 2003-11-26 | Method and device for disinfecting a microtome cryostat |
US12/078,580 Active 2027-02-14 US8246905B2 (en) | 2003-02-01 | 2008-04-02 | Method for disinfecting a microtome cryostat |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/078,580 Active 2027-02-14 US8246905B2 (en) | 2003-02-01 | 2008-04-02 | Method for disinfecting a microtome cryostat |
Country Status (6)
Country | Link |
---|---|
US (2) | US20060133950A1 (de) |
EP (1) | EP1587552B1 (de) |
JP (1) | JP4210654B2 (de) |
AU (1) | AU2003292118A1 (de) |
DE (1) | DE10303989B4 (de) |
WO (1) | WO2004067047A2 (de) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060011856A1 (en) * | 2004-07-15 | 2006-01-19 | Skaggs Donald E | Disinfection and decontamination using ultraviolet light |
US20070204734A1 (en) * | 2006-01-18 | 2007-09-06 | Tetsumasa Ito | Automatic sliced piece fabricating apparatus and automatic sliced piece sample fabricating apparatus |
US20100329925A1 (en) * | 2009-06-25 | 2010-12-30 | Microm International Gmbh | Method and device for disinfecting a microtome cryostat |
CN113786510A (zh) * | 2021-09-18 | 2021-12-14 | 沛县盛玛特新材料研究院有限公司 | 一种医用棉球处理设备 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102012106846B4 (de) * | 2012-07-27 | 2014-09-25 | Leica Biosystems Nussloch Gmbh | Mikrotom mit einem Piezolinearantrieb |
US11073447B2 (en) * | 2016-03-31 | 2021-07-27 | Agilent Technologies, Inc. | Apparatus and methods for transferring a tissue section |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US4952370A (en) * | 1988-05-06 | 1990-08-28 | American Sterilizer Company | Hydrogen peroxide sterilization method |
US5711705A (en) * | 1995-05-25 | 1998-01-27 | Flanders Filters, Inc. | Isolation work station |
US5974811A (en) * | 1997-03-07 | 1999-11-02 | Carl-Zeiss-Stiftung Trading As Carl Zeiss | Suction device for cutting wastes in a cryostatic microtome |
US6589481B1 (en) * | 1996-04-04 | 2003-07-08 | Ethicon, Inc. | Apparatus and method to pretreat and sterilize a lumen device |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3202627A1 (de) * | 1982-01-25 | 1983-08-11 | Melagapparate Gmbh, 1000 Berlin | Verfahren zum abfuehren eines sterilisiermediums aus einem sterilisierapparat und vorrichtung zur durchfuehrung des verfahrens |
US4909999A (en) * | 1987-07-06 | 1990-03-20 | American Sterilizer Company | Flow-through vapor phase sterilization system |
US5122344A (en) * | 1990-01-31 | 1992-06-16 | Mdt Corporation | Chemical sterilizer system |
FR2705587A1 (fr) * | 1993-05-25 | 1994-12-02 | Tabone Herve | Cryostat de microtomie, notamment pour travaux histologiques. |
AUPP427398A0 (en) * | 1998-06-23 | 1998-07-16 | Novapharm Research (Australia) Pty Ltd | Improved disinfection |
GB2354443A (en) * | 1999-09-21 | 2001-03-28 | Microflow Ltd | Vapour phase sterilisation |
US6481219B2 (en) * | 2001-03-30 | 2002-11-19 | Sakura Finetek U.S.A., Inc. | Disinfection system and method of using same |
-
2003
- 2003-02-01 DE DE10303989A patent/DE10303989B4/de not_active Expired - Lifetime
- 2003-11-26 US US10/543,195 patent/US20060133950A1/en not_active Abandoned
- 2003-11-26 WO PCT/EP2003/013267 patent/WO2004067047A2/de active Application Filing
- 2003-11-26 EP EP03767660A patent/EP1587552B1/de not_active Expired - Lifetime
- 2003-11-26 AU AU2003292118A patent/AU2003292118A1/en not_active Abandoned
- 2003-11-26 JP JP2004567298A patent/JP4210654B2/ja not_active Expired - Lifetime
-
2008
- 2008-04-02 US US12/078,580 patent/US8246905B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4952370A (en) * | 1988-05-06 | 1990-08-28 | American Sterilizer Company | Hydrogen peroxide sterilization method |
US5711705A (en) * | 1995-05-25 | 1998-01-27 | Flanders Filters, Inc. | Isolation work station |
US6589481B1 (en) * | 1996-04-04 | 2003-07-08 | Ethicon, Inc. | Apparatus and method to pretreat and sterilize a lumen device |
US5974811A (en) * | 1997-03-07 | 1999-11-02 | Carl-Zeiss-Stiftung Trading As Carl Zeiss | Suction device for cutting wastes in a cryostatic microtome |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060011856A1 (en) * | 2004-07-15 | 2006-01-19 | Skaggs Donald E | Disinfection and decontamination using ultraviolet light |
US7319230B2 (en) * | 2004-07-15 | 2008-01-15 | Skaggs Donald E | Disinfection and decontamination using ultraviolet light |
US20070204734A1 (en) * | 2006-01-18 | 2007-09-06 | Tetsumasa Ito | Automatic sliced piece fabricating apparatus and automatic sliced piece sample fabricating apparatus |
US7802507B2 (en) * | 2006-01-18 | 2010-09-28 | Seiko Instruments Inc. | Automatic sliced piece fabricating apparatus and automatic sliced piece sample fabricating apparatus |
US20100329925A1 (en) * | 2009-06-25 | 2010-12-30 | Microm International Gmbh | Method and device for disinfecting a microtome cryostat |
CN101936821A (zh) * | 2009-06-25 | 2011-01-05 | 迈克罗姆国际股份有限公司 | 用于消毒冷冻切片机的方法和装置 |
US8007719B2 (en) * | 2009-06-25 | 2011-08-30 | Microm International Gmbh | Method and device for disinfecting a microtome cryostat |
CN113786510A (zh) * | 2021-09-18 | 2021-12-14 | 沛县盛玛特新材料研究院有限公司 | 一种医用棉球处理设备 |
Also Published As
Publication number | Publication date |
---|---|
JP2006513749A (ja) | 2006-04-27 |
US8246905B2 (en) | 2012-08-21 |
DE10303989B4 (de) | 2006-07-06 |
EP1587552B1 (de) | 2011-08-17 |
AU2003292118A1 (en) | 2004-08-23 |
JP4210654B2 (ja) | 2009-01-21 |
DE10303989A1 (de) | 2004-08-26 |
WO2004067047A2 (de) | 2004-08-12 |
US20080181814A1 (en) | 2008-07-31 |
WO2004067047A3 (de) | 2004-10-21 |
EP1587552A2 (de) | 2005-10-26 |
AU2003292118A8 (en) | 2004-08-23 |
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