US10384007B2 - Auto-injector - Google Patents

Auto-injector Download PDF

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Publication number
US10384007B2
US10384007B2 US14/435,563 US201314435563A US10384007B2 US 10384007 B2 US10384007 B2 US 10384007B2 US 201314435563 A US201314435563 A US 201314435563A US 10384007 B2 US10384007 B2 US 10384007B2
Authority
US
United States
Prior art keywords
syringe
case
plunger
auto
injector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US14/435,563
Other languages
English (en)
Other versions
US20160175524A1 (en
Inventor
Charley Henderson
David Cross
Douglas Ivan Jennings
Ryan Anthony McGinley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Assigned to SANOFI-AVENTIS DEUTSCHLAND GMBH reassignment SANOFI-AVENTIS DEUTSCHLAND GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CROSS, DAVID, JENNINGS, DOUGLAS, HENDERSON, Charley, McGINLEY, Ryan
Publication of US20160175524A1 publication Critical patent/US20160175524A1/en
Application granted granted Critical
Publication of US10384007B2 publication Critical patent/US10384007B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3553—Range remote, e.g. between patient's home and doctor's office
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
    • F04C2270/00—Control; Monitoring or safety arrangements
    • F04C2270/04—Force
    • F04C2270/042—Force radial
    • F04C2270/0421—Controlled or regulated
US14/435,563 2012-10-18 2013-10-02 Auto-injector Active 2034-07-21 US10384007B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12189092 2012-10-18
EP20120189092 EP2722065A1 (en) 2012-10-18 2012-10-18 Auto-injector
EP12189092.5 2012-10-18
PCT/EP2013/070584 WO2014060216A1 (en) 2012-10-18 2013-10-02 Auto-injector

Publications (2)

Publication Number Publication Date
US20160175524A1 US20160175524A1 (en) 2016-06-23
US10384007B2 true US10384007B2 (en) 2019-08-20

Family

ID=47080338

Family Applications (1)

Application Number Title Priority Date Filing Date
US14/435,563 Active 2034-07-21 US10384007B2 (en) 2012-10-18 2013-10-02 Auto-injector

Country Status (12)

Country Link
US (1) US10384007B2 (ja)
EP (2) EP2722065A1 (ja)
JP (1) JP6352933B2 (ja)
KR (1) KR20150071705A (ja)
CN (1) CN104853788B (ja)
AU (1) AU2013331888A1 (ja)
BR (1) BR112015008448A2 (ja)
HK (1) HK1209660A1 (ja)
IL (1) IL238221A0 (ja)
MX (1) MX2015004938A (ja)
RU (1) RU2015118146A (ja)
WO (1) WO2014060216A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11826551B2 (en) 2019-04-09 2023-11-28 Battelle Memorial Institute Autoinjectors having advanced release and sound features
US11850402B2 (en) 2020-07-09 2023-12-26 Eli Lilly And Company Automatic injection device with reusable portion
US11865316B2 (en) 2020-10-23 2024-01-09 Eli Lilly And Company Medication delivery device including disposable and reusable portions

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2948003C (en) * 2014-06-03 2023-06-27 Amgen Inc. Drug delivery system and method of use
TW201707744A (zh) 2015-06-03 2017-03-01 賽諾菲阿凡提斯德意志有限公司 藥物輸送裝置（二）
PL414382A1 (pl) * 2015-10-15 2017-04-24 Copernicus Spółka Z Ograniczoną Odpowiedzialnością Mechanizm nastawczy, w szczególności do dozowania
US10529252B2 (en) * 2015-11-19 2020-01-07 Noble International, Inc. Resettable shield-activated injection device trainer
WO2017089268A1 (en) * 2015-11-27 2017-06-01 Sanofi-Aventis Deutschland Gmbh An injection device with protective cap allowing electromagnetic field induction
DK3400045T3 (da) 2016-01-06 2020-08-10 Sanofi Aventis Deutschland Medikamentadministrationsanordning
AU2017234647B2 (en) * 2016-03-16 2019-03-28 Eli Lilly And Company Trigger assembly for automatic medication injection device
GB2549750A (en) * 2016-04-27 2017-11-01 Owen Mumford Ltd Medicament delivery device
CN106039475B (zh) * 2016-05-18 2019-08-02 苏州鹏烨医疗科技有限公司 一种注射笔
CA3027992C (en) 2016-06-22 2021-08-03 Antares Pharma, Inc. Needle-shield remover
WO2018068958A1 (en) * 2016-10-11 2018-04-19 H. Lundbeck A/S Needle shield with reduceable needle hole
CN109792301A (zh) * 2016-10-14 2019-05-21 艾斯曲尔医疗公司 配置为通过人体发送数据的自助给药装置
EP3675935B1 (en) 2017-08-30 2021-08-04 Pirouette Medical LLC Compact auto-injector
WO2019071129A1 (en) 2017-10-05 2019-04-11 Pirouette Medical LLC PROTECTIVE HOUSING FOR A SELF-INJECTOR
JP2021500169A (ja) * 2017-10-26 2021-01-07 サノフイＳａｎｏｆｉ 振動発生器を備えた注射デバイス
US11819663B2 (en) 2017-12-19 2023-11-21 Biocorp Production S.A. Auto-injection drug delivery device
CN112043693B (zh) 2020-09-14 2022-12-02 长春金赛药业有限责任公司 含酯基芳香丙酰胺类化合物在制备治疗干眼症药物中的应用

Citations (22)

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US5042977A (en) * 1987-05-08 1991-08-27 Wilhelm Haselmeier Gmbh & Co. Injection device which can be cocked only in the zero position
US6203529B1 (en) * 1997-11-19 2001-03-20 B D Medico Needle arrangement
WO2002053214A1 (en) 2001-01-05 2002-07-11 Novo Nordisk A/S Automatic injection device with reset feature
US20020165500A1 (en) * 1994-05-30 2002-11-07 Herbert Bechtold Injection device
JP2005261855A (ja) 2004-03-22 2005-09-29 Shimadzu Corp 針無圧力注射器
US20060229570A1 (en) * 2002-09-11 2006-10-12 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
US20070021720A1 (en) * 2005-07-15 2007-01-25 Shl Medical Ab Injector
GB2452286A (en) 2007-08-29 2009-03-04 Cilag Gmbh Int Base station to reset an automatic injection device
CN101479000A (zh) 2006-04-12 2009-07-08 特克法马许可公司 具有张紧弹簧和张紧元件的注射装置
WO2009097934A1 (en) 2008-02-05 2009-08-13 Shl Group Ab Injection device with pre-activation means
US20100152671A1 (en) * 2008-12-12 2010-06-17 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a medication delivery device and medication delivery device
WO2010142598A2 (en) * 2009-06-03 2010-12-16 Novo Nordisk A/S Electronically monitored injection device
US20110034881A1 (en) * 2008-02-12 2011-02-10 Shl Group Ab Auto-Injector
US20110092905A1 (en) 2009-10-16 2011-04-21 Owen Mumford Limited Injector apparatus
WO2011101382A1 (en) 2010-02-22 2011-08-25 Sanofi-Aventis Deutschland Gmbh Auto - injector with needle shroud and needle protection cap
WO2011123024A1 (en) 2010-03-31 2011-10-06 Shl Group Ab Medicament delivery device comprising feedback signalling means
US20120136315A1 (en) * 2009-06-05 2012-05-31 Shl Group Ab Medicament Delivery Device
EP2468329A1 (en) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Auto injector with a torsion spring
WO2012085028A1 (en) * 2010-12-21 2012-06-28 Sanofi-Aventis Deutschland Gmbh Back-end device for an auto-injector and auto-injector
US20120184917A1 (en) * 2009-07-08 2012-07-19 Novo Nordisk A/S Frost protected injection device
WO2012130901A1 (en) 2011-03-30 2012-10-04 Sanofi-Aventis Deutschland Gmbh Injection device
US20140243757A1 (en) * 2011-10-21 2014-08-28 Sanofi-Aventis Deutschland Gmbh Indicator Arrangement for an Auto-Injector

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JP5324654B2 (ja) * 2008-09-09 2013-10-23 エス・ホー・エル・グループ・アクチボラゲット 薬剤送達装置
US9072839B2 (en) * 2010-11-29 2015-07-07 Sanofi-Aventis Deutschland Gmbh Automatic delivery device with triggering mechanism

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US5042977A (en) * 1987-05-08 1991-08-27 Wilhelm Haselmeier Gmbh & Co. Injection device which can be cocked only in the zero position
US20020165500A1 (en) * 1994-05-30 2002-11-07 Herbert Bechtold Injection device
US6203529B1 (en) * 1997-11-19 2001-03-20 B D Medico Needle arrangement
WO2002053214A1 (en) 2001-01-05 2002-07-11 Novo Nordisk A/S Automatic injection device with reset feature
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JP2004516895A (ja) 2001-01-05 2004-06-10 ノボ ノルディスク アクティーゼルスカブ リセット特性を有する自動注射器
US20060229570A1 (en) * 2002-09-11 2006-10-12 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
JP2005261855A (ja) 2004-03-22 2005-09-29 Shimadzu Corp 針無圧力注射器
US20070021720A1 (en) * 2005-07-15 2007-01-25 Shl Medical Ab Injector
CN101479000A (zh) 2006-04-12 2009-07-08 特克法马许可公司 具有张紧弹簧和张紧元件的注射装置
GB2452286A (en) 2007-08-29 2009-03-04 Cilag Gmbh Int Base station to reset an automatic injection device
CN101801441A (zh) 2007-08-29 2010-08-11 西拉格国际有限公司 具有基座的注射系统
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EP2468329A1 (en) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Auto injector with a torsion spring
WO2012085028A1 (en) * 2010-12-21 2012-06-28 Sanofi-Aventis Deutschland Gmbh Back-end device for an auto-injector and auto-injector
WO2012130901A1 (en) 2011-03-30 2012-10-04 Sanofi-Aventis Deutschland Gmbh Injection device
US20140243757A1 (en) * 2011-10-21 2014-08-28 Sanofi-Aventis Deutschland Gmbh Indicator Arrangement for an Auto-Injector

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Title
Chinese Office Action in Application No. 2013/80065504.5, dated Sep. 11, 2017, 8 pages.
Extended European Search Report in Application No. 12189092.5, dated Mar. 6, 2013, 5 pages.
International Preliminary Report on Patentability in International Application No. PCT/EP2013/070584, dated Apr. 21, 2015, 6 pages.
International Search Report and Written Opinion in International Application No. PCT/EP2013/070584, dated Dec. 11, 2013, 9 pages.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11826551B2 (en) 2019-04-09 2023-11-28 Battelle Memorial Institute Autoinjectors having advanced release and sound features
US11850402B2 (en) 2020-07-09 2023-12-26 Eli Lilly And Company Automatic injection device with reusable portion
US11865316B2 (en) 2020-10-23 2024-01-09 Eli Lilly And Company Medication delivery device including disposable and reusable portions

Also Published As

Publication number Publication date
BR112015008448A2 (pt) 2017-07-04
JP6352933B2 (ja) 2018-07-04
EP2722065A1 (en) 2014-04-23
RU2015118146A (ru) 2016-12-10
CN104853788A (zh) 2015-08-19
EP2908886A1 (en) 2015-08-26
CN104853788B (zh) 2019-05-07
IL238221A0 (en) 2015-06-30
AU2013331888A1 (en) 2015-04-30
KR20150071705A (ko) 2015-06-26
WO2014060216A1 (en) 2014-04-24
US20160175524A1 (en) 2016-06-23
HK1209660A1 (en) 2016-04-08
MX2015004938A (es) 2015-07-21
JP2015532157A (ja) 2015-11-09

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