UA99735C2 - Конденсированные бициклические пиримидины - Google Patents

Конденсированные бициклические пиримидины

Info

Publication number
UA99735C2
UA99735C2 UAA201002746A UAA201002746A UA99735C2 UA 99735 C2 UA99735 C2 UA 99735C2 UA A201002746 A UAA201002746 A UA A201002746A UA A201002746 A UAA201002746 A UA A201002746A UA 99735 C2 UA99735 C2 UA 99735C2
Authority
UA
Ukraine
Prior art keywords
fused bicyclic
bicyclic pyrimidines
pyrimidines
fused
pi3k
Prior art date
Application number
UAA201002746A
Other languages
English (en)
Ukrainian (uk)
Inventor
Свен Хьольдер
Маттіас Феннеманн
Герріт Бенеке
Армін Цюльх
Фолькер Гекелер
Томас Беккерс
Астрід Ціммерманн
Хемант Джоші
Original Assignee
Байєр Фарма Акцієнгезелльшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/en
Application filed by Байєр Фарма Акцієнгезелльшафт filed Critical Байєр Фарма Акцієнгезелльшафт
Publication of UA99735C2 publication Critical patent/UA99735C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

Соединения формулы (I) (I), их таутомеры или стереоизомеры, или их соли, где кольцо В и пиримидин, к которому оно приконденсировано, R4, R5, R6 и R7 имеют значения, приведенные в описании и формуле изобретения, являются эффективными ингибиторами Pi3K/Akt-пути.
UAA201002746A 2007-08-14 2008-08-14 Конденсированные бициклические пиримидины UA99735C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (en) 2007-10-18 2007-10-18 Novel fused pyrimidines
PCT/EP2008/060690 WO2009021992A2 (en) 2007-08-14 2008-08-14 Fused bicyclic pyrimidines

Publications (1)

Publication Number Publication Date
UA99735C2 true UA99735C2 (ru) 2012-09-25

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201002746A UA99735C2 (ru) 2007-08-14 2008-08-14 Конденсированные бициклические пиримидины

Country Status (38)

Country Link
US (2) US7776864B2 (ru)
EP (1) EP2188291B1 (ru)
JP (1) JP5344637B2 (ru)
KR (1) KR20100053556A (ru)
CN (1) CN101778851B (ru)
AR (1) AR067945A1 (ru)
AU (1) AU2008288392B2 (ru)
BR (1) BRPI0815207A2 (ru)
CA (1) CA2694058C (ru)
CL (1) CL2008002398A1 (ru)
CO (1) CO6260077A2 (ru)
CR (1) CR11270A (ru)
CY (1) CY1113486T1 (ru)
DK (1) DK2188291T3 (ru)
DO (1) DOP2010000058A (ru)
EA (1) EA020996B1 (ru)
EC (1) ECSP109964A (ru)
ES (1) ES2396177T3 (ru)
HK (1) HK1146273A1 (ru)
HN (1) HN2010000313A (ru)
HR (1) HRP20121022T1 (ru)
IL (1) IL203163A (ru)
MA (1) MA31608B1 (ru)
MX (1) MX2010001746A (ru)
MY (1) MY169738A (ru)
NZ (1) NZ583267A (ru)
PA (1) PA8793201A1 (ru)
PE (1) PE20090944A1 (ru)
PL (1) PL2188291T3 (ru)
PT (1) PT2188291E (ru)
RS (1) RS52559B (ru)
SI (1) SI2188291T1 (ru)
SV (1) SV2010003483A (ru)
TN (1) TN2010000070A1 (ru)
TW (1) TWI439272B (ru)
UA (1) UA99735C2 (ru)
UY (1) UY31293A1 (ru)
WO (1) WO2009021992A2 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101444486B1 (ko) * 2006-10-19 2014-09-24 다케다 야쿠힌 고교 가부시키가이샤 인돌 화합물
EP2188291B1 (en) 2007-08-14 2012-09-19 Bayer Pharma Aktiengesellschaft Fused bicyclic pyrimidines
JP5599783B2 (ja) 2008-05-30 2014-10-01 アムジエン・インコーポレーテツド Ｐｉ３キナーゼの阻害薬
ES2435804T3 (es) * 2009-02-13 2013-12-23 Bayer Intellectual Property Gmbh Pirimidinas condensadas como inhibidores de Akt
US8957064B2 (en) * 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines
EP2413932A4 (en) * 2009-04-01 2012-09-19 Merck Sharp & Dohme INHIBITORS OF AKT ACTIVITY
TW201103943A (en) 2009-04-27 2011-02-01 Shionogi & Co Urea derivative having pi3k inhibitory activity
WO2012007416A1 (en) 2010-07-13 2012-01-19 Bayer Pharma Aktiengesellschaft Bicyclic pyrimidines
WO2012013713A2 (en) 2010-07-28 2012-02-02 Bayer Pharma Aktiengesellschaft Substituted imidazo[1,2-b]pyridazines
HUE026323T2 (en) 2011-04-07 2016-05-30 Bayer Ip Gmbh Imidazopyridazines as AKT kinase inhibitors
AU2014208964B2 (en) 2013-01-23 2016-09-01 Astrazeneca Ab Chemical compounds
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
EP2967030A2 (en) * 2013-03-15 2016-01-20 Bayer CropScience LP Compositions, additives, and methods for mitigating or controlling seed dust
CN111212839A (zh) 2017-09-15 2020-05-29 艾杜罗生物科技公司 吡唑并嘧啶酮化合物及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7306201A (en) 2000-06-30 2002-01-14 American Home Prod Substituted-triazolopyrimidines as anticancer agents
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
EP1622616B1 (en) 2003-04-24 2011-06-15 Merck Sharp & Dohme Corp. Inhibitors of akt activity
CN1942465A (zh) * 2004-04-09 2007-04-04 默克公司 Akt活性抑制剂
TW200618800A (en) * 2004-08-03 2006-06-16 Uriach Y Compania S A J Heterocyclic compounds
US7544677B2 (en) * 2004-08-23 2009-06-09 Merck & Co., Inc. Inhibitors of Akt activity
US7910561B2 (en) 2004-12-15 2011-03-22 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US7994172B2 (en) * 2004-12-28 2011-08-09 Exelixis, Inc. [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases
CN101115479A (zh) 2005-02-14 2008-01-30 默克公司 Akt活性抑制剂
PT1898903E (pt) 2005-06-10 2013-06-28 Merck Sharp & Dohme Inibidores da atividade de akt
EP2188291B1 (en) 2007-08-14 2012-09-19 Bayer Pharma Aktiengesellschaft Fused bicyclic pyrimidines
US8957064B2 (en) * 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines

Also Published As

Publication number Publication date
SV2010003483A (es) 2010-07-06
JP5344637B2 (ja) 2013-11-20
JP2010535848A (ja) 2010-11-25
AR067945A1 (es) 2009-10-28
DOP2010000058A (es) 2010-02-28
CN101778851A (zh) 2010-07-14
EA201000298A1 (ru) 2010-10-29
HK1146273A1 (en) 2011-05-20
EA020996B1 (ru) 2015-03-31
RS52559B (en) 2013-04-30
PE20090944A1 (es) 2009-08-09
SI2188291T1 (sl) 2013-01-31
PT2188291E (pt) 2012-12-20
NZ583267A (en) 2012-03-30
WO2009021992A2 (en) 2009-02-19
CN101778851B (zh) 2013-05-08
MX2010001746A (es) 2010-03-10
US7776864B2 (en) 2010-08-17
AU2008288392A1 (en) 2009-02-19
US8614218B2 (en) 2013-12-24
MA31608B1 (fr) 2010-08-02
UY31293A1 (es) 2009-03-31
CY1113486T1 (el) 2016-06-22
EP2188291B1 (en) 2012-09-19
AU2008288392B2 (en) 2013-10-24
MY169738A (en) 2019-05-14
BRPI0815207A2 (pt) 2017-03-28
TWI439272B (zh) 2014-06-01
DK2188291T3 (da) 2013-01-07
CO6260077A2 (es) 2011-03-22
CR11270A (es) 2010-05-19
PA8793201A1 (es) 2009-04-23
HN2010000313A (es) 2013-03-18
EP2188291A2 (en) 2010-05-26
ECSP109964A (es) 2010-03-31
US20090137607A1 (en) 2009-05-28
HRP20121022T1 (hr) 2013-01-31
CA2694058C (en) 2016-06-07
CA2694058A1 (en) 2009-02-19
WO2009021992A3 (en) 2009-04-16
TW200922592A (en) 2009-06-01
IL203163A (en) 2015-01-29
TN2010000070A1 (en) 2011-09-26
PL2188291T3 (pl) 2013-06-28
CL2008002398A1 (es) 2009-07-31
ES2396177T3 (es) 2013-02-19
US20100184782A1 (en) 2010-07-22
KR20100053556A (ko) 2010-05-20

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