UA82833C2 - Кристаллическая натриевая соль телмисартана и ее применение в качестве антагониста ангиотензина - Google Patents

Кристаллическая натриевая соль телмисартана и ее применение в качестве антагониста ангиотензина Download PDF

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Publication number
UA82833C2
UA82833C2 UA20040503959A UA20040503959A UA82833C2 UA 82833 C2 UA82833 C2 UA 82833C2 UA 20040503959 A UA20040503959 A UA 20040503959A UA 20040503959 A UA20040503959 A UA 20040503959A UA 82833 C2 UA82833 C2 UA 82833C2
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telmisartan
sodium salt
formula
acid
crystalline
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UA20040503959A
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English (en)
Ukrainian (uk)
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Кай Донсбах
Ірмгард Хоф
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Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг
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Application filed by Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг filed Critical Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг
Publication of UA82833C2 publication Critical patent/UA82833C2/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В заявке описана кристаллическая натриевая соль 4'-[2-н-пропил-4-метил-6-(1-метилбензимидазол-2-ил)бензимидазол-1-илметил]бифенил-2-карбоновой кислоты (международное непатентованное название телмисартан), способ ее получения, а также ее применения для получения лекарственного средства, которое имеет действие антагониста ангиотензина II.
UA20040503959A 2001-10-31 2002-11-10 Кристаллическая натриевая соль телмисартана и ее применение в качестве антагониста ангиотензина UA82833C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10153737A DE10153737A1 (de) 2001-10-31 2001-10-31 Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
PCT/EP2002/011394 WO2003037876A1 (de) 2001-10-31 2002-10-11 Kristallines natriumsalz des telmisartans und dessen verwendung als angiotensin antagonist

Publications (1)

Publication Number Publication Date
UA82833C2 true UA82833C2 (ru) 2008-05-26

Family

ID=7704331

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20040503959A UA82833C2 (ru) 2001-10-31 2002-11-10 Кристаллическая натриевая соль телмисартана и ее применение в качестве антагониста ангиотензина

Country Status (35)

Country Link
EP (1) EP1442023B1 (ru)
JP (1) JP5124076B2 (ru)
KR (1) KR100929502B1 (ru)
CN (1) CN100509789C (ru)
AR (1) AR037148A1 (ru)
AT (1) ATE370125T1 (ru)
AU (1) AU2002338886B2 (ru)
BR (1) BR0213568A (ru)
CA (1) CA2463146C (ru)
CO (1) CO5580785A2 (ru)
CY (1) CY1107504T1 (ru)
DE (2) DE10153737A1 (ru)
DK (1) DK1442023T3 (ru)
EA (1) EA007596B1 (ru)
EC (1) ECSP045089A (ru)
ES (1) ES2291505T3 (ru)
HK (1) HK1073841A1 (ru)
HR (1) HRPK20040372B3 (ru)
HU (1) HUP0402391A3 (ru)
IL (2) IL161165A0 (ru)
ME (1) MEP43608A (ru)
MX (1) MXPA04004013A (ru)
MY (1) MY129741A (ru)
NO (1) NO326465B1 (ru)
NZ (1) NZ532716A (ru)
PE (1) PE20030629A1 (ru)
PL (1) PL211462B1 (ru)
PT (1) PT1442023E (ru)
RS (1) RS50879B (ru)
SA (1) SA02230419B1 (ru)
SI (1) SI1442023T1 (ru)
TW (2) TWI341200B (ru)
UA (1) UA82833C2 (ru)
UY (1) UY27520A1 (ru)
WO (1) WO2003037876A1 (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319450A1 (de) * 2003-04-30 2004-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Formulierung des Telmisartan Natriumsalzes
US9029363B2 (en) 2003-04-30 2015-05-12 Boehringer Ingelheim International Gmbh Telmisartan sodium salt pharmaceutical formulation
WO2005077941A2 (en) 2004-02-11 2005-08-25 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
CN1953973A (zh) * 2004-05-05 2007-04-25 特瓦制药工业有限公司 高纯度坎地沙坦酯的制备
WO2006044754A2 (en) 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
WO2006050509A2 (en) * 2004-11-03 2006-05-11 Teva Pharmaceutical Industries Ltd. Amorphous and polymorphic forms of telmisartan sodium
EP1908469A1 (en) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II receptor antagonist for the treatment of systemic diseases in cats
EP2151450A1 (de) * 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
MX346039B (es) 2009-05-20 2017-03-03 Boehringer Ingelheim Vetmedica Gmbh Solucion farmaceutica bebible de telmisartan.
EP2448576A2 (en) 2009-07-02 2012-05-09 Mahmut Bilgic Solubility enhancing pharmaceutical composition
EP2448575A2 (en) 2009-07-02 2012-05-09 Bilgic Mahmut Pharmaceutical composition increasing solubility and stability
EP2632438A1 (en) 2010-10-27 2013-09-04 KRKA, tovarna zdravil, d.d., Novo mesto Multilayer pharmaceutical composition comprising telmisartan and amlodipine
CN103619556B (zh) * 2011-06-24 2016-12-07 本田技研工业株式会社 注塑成形方法及其装置
ES2864009T3 (es) 2011-11-25 2021-10-13 Adverio Pharma Gmbh 5-Fluoro-1H-pirazolopiridinas sustituidas en forma cristalina
KR102331856B1 (ko) 2014-10-21 2021-11-29 다케다 야쿠힌 고교 가부시키가이샤 결정 형태의 5-클로로-n4-[2-(디메틸포스포릴)페닐]-n2-{2-메톡시-4-[4-(4-메틸피페라진-1-일)피페리딘-1-일]피리미딘-2,4-디아민
KR101872726B1 (ko) * 2016-07-28 2018-06-29 주식회사 씨트리 텔미사르탄 메탄술폰산염 및 이를 포함하는 약제학적 조성물
CA3067918A1 (en) 2017-07-07 2019-01-10 Boehringer Ingelheim Vetmedica Gmbh Angiotensin ii receptor antagonish for the prevention or treatment of hypertension in cats
CN113330013B (zh) * 2019-01-10 2022-12-27 石药集团中奇制药技术(石家庄)有限公司 杂环化合物盐及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5594003A (en) * 1991-02-06 1997-01-14 Dr. Karl Thomae Gmbh Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists
JP4369994B2 (ja) * 1996-02-29 2009-11-25 ノバルティス アクチエンゲゼルシャフト アポトーシスの刺激のためのat▲下1▼レセプターアンタゴニスト
DE19901921C2 (de) * 1999-01-19 2001-01-04 Boehringer Ingelheim Pharma Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels

Also Published As

Publication number Publication date
NO326465B1 (no) 2008-12-08
CY1107504T1 (el) 2013-03-13
HRP20040372A2 (en) 2004-10-31
UY27520A1 (es) 2003-05-30
ES2291505T3 (es) 2008-03-01
KR20050035172A (ko) 2005-04-15
HK1073841A1 (en) 2005-10-21
SI1442023T1 (sl) 2007-12-31
PL367477A1 (en) 2005-02-21
DE50210719D1 (de) 2007-09-27
DK1442023T3 (da) 2007-11-05
ATE370125T1 (de) 2007-09-15
CN1578772A (zh) 2005-02-09
EP1442023A1 (de) 2004-08-04
EP1442023B1 (de) 2007-08-15
MY129741A (en) 2007-04-30
PE20030629A1 (es) 2003-07-14
JP2005536445A (ja) 2005-12-02
NZ532716A (en) 2007-06-29
CA2463146C (en) 2011-01-25
DE10153737A1 (de) 2003-05-28
TWI341200B (en) 2011-05-01
AR037148A1 (es) 2004-10-27
CA2463146A1 (en) 2003-05-08
HRPK20040372B3 (en) 2006-02-28
IL161165A (en) 2009-12-24
SA02230419B1 (ar) 2007-07-31
PT1442023E (pt) 2007-09-17
MXPA04004013A (es) 2004-06-18
RS50879B (sr) 2010-08-31
KR100929502B1 (ko) 2009-12-03
PL211462B1 (pl) 2012-05-31
HUP0402391A2 (hu) 2005-03-29
TW200300082A (en) 2003-05-16
JP5124076B2 (ja) 2013-01-23
IL161165A0 (en) 2004-08-31
HUP0402391A3 (en) 2010-03-29
TW201034664A (en) 2010-10-01
YU36304A (sh) 2006-08-17
MEP43608A (en) 2011-02-10
EA200400479A1 (ru) 2004-10-28
EA007596B1 (ru) 2006-12-29
CO5580785A2 (es) 2005-11-30
AU2002338886B2 (en) 2008-04-17
CN100509789C (zh) 2009-07-08
NO20041758L (no) 2004-04-29
TWI333419B (en) 2010-11-21
WO2003037876A1 (de) 2003-05-08
ECSP045089A (es) 2004-06-28
BR0213568A (pt) 2004-09-08

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