HUP0402391A2 - Telmisartan kristályos nátriumsója, eljárás előállítására és az azt tartalmazó gyógyszerkészítmények - Google Patents
Telmisartan kristályos nátriumsója, eljárás előállítására és az azt tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0402391A2 HUP0402391A2 HU0402391A HUP0402391A HUP0402391A2 HU P0402391 A2 HUP0402391 A2 HU P0402391A2 HU 0402391 A HU0402391 A HU 0402391A HU P0402391 A HUP0402391 A HU P0402391A HU P0402391 A2 HUP0402391 A2 HU P0402391A2
- Authority
- HU
- Hungary
- Prior art keywords
- production
- telmisartan
- sodium salt
- crystalline sodium
- pharmaceutical compositions
- Prior art date
Links
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000005537 C09CA07 - Telmisartan Substances 0.000 title abstract 2
- 159000000000 sodium salts Chemical class 0.000 title abstract 2
- 229960005187 telmisartan Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940123073 Angiotensin antagonist Drugs 0.000 abstract 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgyát a 4'-{[2-propil-4-metil-6-(1-metil-benzimidazol-2-il)-benzimidazol-l-il]-metil}]-bifenil-2-karbonsav (INN: Telmisartan)képletű kristályos nátriumsója, eljárás előállítására és gyógyszerekelőállítására való alkalmazása képezi. A vegyület angiotenziaantagonista hatású. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10153737A DE10153737A1 (de) | 2001-10-31 | 2001-10-31 | Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels |
PCT/EP2002/011394 WO2003037876A1 (de) | 2001-10-31 | 2002-10-11 | Kristallines natriumsalz des telmisartans und dessen verwendung als angiotensin antagonist |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0402391A2 true HUP0402391A2 (hu) | 2005-03-29 |
HUP0402391A3 HUP0402391A3 (en) | 2010-03-29 |
Family
ID=7704331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0402391A HUP0402391A3 (en) | 2001-10-31 | 2002-10-11 | Crystalline sodium salt of telmisartan, process for its production and pharmaceutical compositions containing it |
Country Status (35)
Country | Link |
---|---|
EP (1) | EP1442023B1 (hu) |
JP (1) | JP5124076B2 (hu) |
KR (1) | KR100929502B1 (hu) |
CN (1) | CN100509789C (hu) |
AR (1) | AR037148A1 (hu) |
AT (1) | ATE370125T1 (hu) |
AU (1) | AU2002338886B2 (hu) |
BR (1) | BR0213568A (hu) |
CA (1) | CA2463146C (hu) |
CO (1) | CO5580785A2 (hu) |
CY (1) | CY1107504T1 (hu) |
DE (2) | DE10153737A1 (hu) |
DK (1) | DK1442023T3 (hu) |
EA (1) | EA007596B1 (hu) |
EC (1) | ECSP045089A (hu) |
ES (1) | ES2291505T3 (hu) |
HK (1) | HK1073841A1 (hu) |
HR (1) | HRPK20040372B3 (hu) |
HU (1) | HUP0402391A3 (hu) |
IL (2) | IL161165A0 (hu) |
ME (1) | MEP43608A (hu) |
MX (1) | MXPA04004013A (hu) |
MY (1) | MY129741A (hu) |
NO (1) | NO326465B1 (hu) |
NZ (1) | NZ532716A (hu) |
PE (1) | PE20030629A1 (hu) |
PL (1) | PL211462B1 (hu) |
PT (1) | PT1442023E (hu) |
RS (1) | RS50879B (hu) |
SA (1) | SA02230419B1 (hu) |
SI (1) | SI1442023T1 (hu) |
TW (2) | TWI341200B (hu) |
UA (1) | UA82833C2 (hu) |
UY (1) | UY27520A1 (hu) |
WO (1) | WO2003037876A1 (hu) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9029363B2 (en) | 2003-04-30 | 2015-05-12 | Boehringer Ingelheim International Gmbh | Telmisartan sodium salt pharmaceutical formulation |
DE10319450A1 (de) * | 2003-04-30 | 2004-11-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische Formulierung des Telmisartan Natriumsalzes |
WO2005077941A2 (en) | 2004-02-11 | 2005-08-25 | Teva Pharmaceutical Industries Ltd. | Candesartan cilexetil polymorphs |
KR100908308B1 (ko) * | 2004-05-05 | 2009-07-17 | 테바 파마슈티컬 인더스트리즈 리미티드 | 순도가 높은 칸데사르탄 실렉세틸의 제조 |
EP1805146A4 (en) | 2004-10-18 | 2009-01-14 | Reddys Lab Ltd Dr | PROCESS FOR THE PREPARATION OF TELMISARTAN |
KR20070072588A (ko) * | 2004-11-03 | 2007-07-04 | 테바 파마슈티컬 인더스트리즈 리미티드 | 텔미사르탄 나트륨의 비정질형 및 다형 |
EP1908469A1 (en) | 2006-10-06 | 2008-04-09 | Boehringer Ingelheim Vetmedica Gmbh | Angiotensin II receptor antagonist for the treatment of systemic diseases in cats |
EP2151450A1 (de) * | 2008-07-29 | 2010-02-10 | Sandoz AG | Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden |
DK2432452T3 (en) | 2009-05-20 | 2016-10-10 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutically telmisartan drink solution |
WO2011002423A2 (en) | 2009-07-02 | 2011-01-06 | Mahmut Bilgic | Solubility enhancing pharmaceutical composition |
EP2448575A2 (en) | 2009-07-02 | 2012-05-09 | Bilgic Mahmut | Pharmaceutical composition increasing solubility and stability |
WO2012055941A1 (en) | 2010-10-27 | 2012-05-03 | Krka,Tovarna Zdravil, D. D., Novo Mesto | Multilayer pharmaceutical composition comprising telmisartan and amlodipine |
US9561610B2 (en) * | 2011-06-24 | 2017-02-07 | Honda Motor Co., Ltd. | Injection molding method and apparatus therefor |
PL3421470T3 (pl) | 2011-11-25 | 2021-08-02 | Adverio Pharma Gmbh | Podstawione 5-fluoro-1H-pirazolopirydyny w postaci krystalicznej |
DK3209647T3 (da) | 2014-10-21 | 2020-08-24 | Ariad Pharma Inc | Krystallinske former af 5-chlor-n4-[-2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl]pyrimidin-2,4-diamin |
KR101872726B1 (ko) * | 2016-07-28 | 2018-06-29 | 주식회사 씨트리 | 텔미사르탄 메탄술폰산염 및 이를 포함하는 약제학적 조성물 |
KR20200026975A (ko) | 2017-07-07 | 2020-03-11 | 베링거잉겔하임베트메디카게엠베하 | 고양이에서 전신 질환의 예방 또는 치료를 위한 안지오텐신 ii 수용체 길항제 |
JP2022517610A (ja) * | 2019-01-10 | 2022-03-09 | シーエスピーシー ゾンチー ファーマシューティカル テクノロジー(シージアチュアン)カンパニー,リミテッド | 複素環化合物塩およびその使用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI9210098B (sl) * | 1991-02-06 | 2000-06-30 | Dr. Karl Thomae | Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo |
US5594003A (en) * | 1991-02-06 | 1997-01-14 | Dr. Karl Thomae Gmbh | Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists |
ATE230263T1 (de) * | 1996-02-29 | 2003-01-15 | Novartis Erfind Verwalt Gmbh | At1 rezeptor antagonist zur anregung von apoptosis |
DE19901921C2 (de) * | 1999-01-19 | 2001-01-04 | Boehringer Ingelheim Pharma | Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels |
-
2001
- 2001-10-31 DE DE10153737A patent/DE10153737A1/de not_active Ceased
-
2002
- 2002-10-11 NZ NZ532716A patent/NZ532716A/en not_active IP Right Cessation
- 2002-10-11 RS YUP-363/04A patent/RS50879B/sr unknown
- 2002-10-11 PT PT02777305T patent/PT1442023E/pt unknown
- 2002-10-11 DE DE50210719T patent/DE50210719D1/de not_active Expired - Lifetime
- 2002-10-11 PL PL367477A patent/PL211462B1/pl unknown
- 2002-10-11 KR KR1020047006317A patent/KR100929502B1/ko not_active IP Right Cessation
- 2002-10-11 SI SI200230594T patent/SI1442023T1/sl unknown
- 2002-10-11 ES ES02777305T patent/ES2291505T3/es not_active Expired - Lifetime
- 2002-10-11 ME MEP-436/08A patent/MEP43608A/xx unknown
- 2002-10-11 CA CA2463146A patent/CA2463146C/en not_active Expired - Fee Related
- 2002-10-11 DK DK02777305T patent/DK1442023T3/da active
- 2002-10-11 BR BR0213568-0A patent/BR0213568A/pt active Pending
- 2002-10-11 AU AU2002338886A patent/AU2002338886B2/en not_active Ceased
- 2002-10-11 IL IL16116502A patent/IL161165A0/xx unknown
- 2002-10-11 EP EP02777305A patent/EP1442023B1/de not_active Expired - Lifetime
- 2002-10-11 EA EA200400479A patent/EA007596B1/ru not_active IP Right Cessation
- 2002-10-11 HU HU0402391A patent/HUP0402391A3/hu not_active Application Discontinuation
- 2002-10-11 CN CNB028216202A patent/CN100509789C/zh not_active Expired - Fee Related
- 2002-10-11 MX MXPA04004013A patent/MXPA04004013A/es active IP Right Grant
- 2002-10-11 AT AT02777305T patent/ATE370125T1/de active
- 2002-10-11 JP JP2003540158A patent/JP5124076B2/ja not_active Expired - Lifetime
- 2002-10-11 WO PCT/EP2002/011394 patent/WO2003037876A1/de active IP Right Grant
- 2002-10-28 PE PE2002001061A patent/PE20030629A1/es not_active Application Discontinuation
- 2002-10-28 UY UY27520A patent/UY27520A1/es not_active Application Discontinuation
- 2002-10-29 TW TW099114822A patent/TWI341200B/zh not_active IP Right Cessation
- 2002-10-29 MY MYPI20024051A patent/MY129741A/en unknown
- 2002-10-29 TW TW091132070A patent/TWI333419B/zh not_active IP Right Cessation
- 2002-10-30 AR ARP020104113A patent/AR037148A1/es active Pending
- 2002-11-05 SA SA02230419A patent/SA02230419B1/ar unknown
- 2002-11-10 UA UA20040503959A patent/UA82833C2/uk unknown
-
2004
- 2004-03-30 IL IL161165A patent/IL161165A/en not_active IP Right Cessation
- 2004-04-26 HR HR20040372A patent/HRPK20040372B3/xx not_active IP Right Cessation
- 2004-04-27 EC EC2004005089A patent/ECSP045089A/es unknown
- 2004-04-29 NO NO20041758A patent/NO326465B1/no not_active IP Right Cessation
- 2004-05-07 CO CO04042445A patent/CO5580785A2/es not_active Application Discontinuation
-
2005
- 2005-07-26 HK HK05106371.1A patent/HK1073841A1/xx not_active IP Right Cessation
-
2007
- 2007-10-15 CY CY20071101332T patent/CY1107504T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC4A | Lapse of provisional application due to refusal |