UA81403C2 - Peptide capable to bind casein kinase ii (ckii) phosphorylating site and to inhibit phosphorylation and use thereof - Google Patents
Peptide capable to bind casein kinase ii (ckii) phosphorylating site and to inhibit phosphorylation and use thereof Download PDFInfo
- Publication number
- UA81403C2 UA81403C2 UA20040705927A UA20040705927A UA81403C2 UA 81403 C2 UA81403 C2 UA 81403C2 UA 20040705927 A UA20040705927 A UA 20040705927A UA 20040705927 A UA20040705927 A UA 20040705927A UA 81403 C2 UA81403 C2 UA 81403C2
- Authority
- UA
- Ukraine
- Prior art keywords
- peptides
- cells
- ifn
- site
- phosphorylation
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 91
- 238000006366 phosphorylation reaction Methods 0.000 title claims abstract description 35
- 230000026731 phosphorylation Effects 0.000 title claims abstract description 28
- 102000052052 Casein Kinase II Human genes 0.000 title abstract description 6
- 108010010919 Casein Kinase II Proteins 0.000 title abstract description 6
- SLPJGDQJLTYWCI-UHFFFAOYSA-N dimethyl-(4,5,6,7-tetrabromo-1h-benzoimidazol-2-yl)-amine Chemical compound BrC1=C(Br)C(Br)=C2NC(N(C)C)=NC2=C1Br SLPJGDQJLTYWCI-UHFFFAOYSA-N 0.000 title abstract description 6
- 230000000865 phosphorylative effect Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 75
- 102000014150 Interferons Human genes 0.000 claims abstract description 21
- 108010050904 Interferons Proteins 0.000 claims abstract description 21
- 229940079322 interferon Drugs 0.000 claims abstract description 20
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 18
- 201000011510 cancer Diseases 0.000 claims description 14
- 210000004881 tumor cell Anatomy 0.000 claims description 8
- 108050007496 Shikimate kinase 2 Proteins 0.000 claims description 7
- 102000004127 Cytokines Human genes 0.000 claims description 6
- 108090000695 Cytokines Proteins 0.000 claims description 6
- 125000004122 cyclic group Chemical group 0.000 claims description 5
- 230000036210 malignancy Effects 0.000 claims description 5
- 230000004663 cell proliferation Effects 0.000 claims description 4
- 230000005764 inhibitory process Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 3
- 239000013604 expression vector Substances 0.000 claims description 3
- 230000003902 lesion Effects 0.000 claims description 3
- 230000004927 fusion Effects 0.000 claims description 2
- 241000701806 Human papillomavirus Species 0.000 claims 2
- 102000008122 Casein Kinase I Human genes 0.000 claims 1
- 108010049812 Casein Kinase I Proteins 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 abstract description 6
- 231100000590 oncogenic Toxicity 0.000 abstract description 6
- 230000002246 oncogenic effect Effects 0.000 abstract description 6
- 230000003993 interaction Effects 0.000 abstract description 5
- 230000001085 cytostatic effect Effects 0.000 abstract description 4
- 230000035945 sensitivity Effects 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 3
- 201000009030 Carcinoma Diseases 0.000 abstract description 2
- 241001631646 Papillomaviridae Species 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 231100000135 cytotoxicity Toxicity 0.000 abstract description 2
- 230000003013 cytotoxicity Effects 0.000 abstract description 2
- 230000003834 intracellular effect Effects 0.000 abstract description 2
- 241000341655 Human papillomavirus type 16 Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 40
- 230000000694 effects Effects 0.000 description 14
- 102000001189 Cyclic Peptides Human genes 0.000 description 11
- 108010069514 Cyclic Peptides Proteins 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 108091008819 oncoproteins Proteins 0.000 description 7
- 102000027450 oncoproteins Human genes 0.000 description 7
- 230000004044 response Effects 0.000 description 7
- 241000725303 Human immunodeficiency virus Species 0.000 description 6
- 230000035755 proliferation Effects 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 230000014509 gene expression Effects 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 description 4
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 description 4
- 101100042793 Gallus gallus SMC2 gene Proteins 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 108020004999 messenger RNA Proteins 0.000 description 4
- 229960005486 vaccine Drugs 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 201000010881 cervical cancer Diseases 0.000 description 3
- 210000003679 cervix uteri Anatomy 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 102000005403 Casein Kinases Human genes 0.000 description 2
- 108010031425 Casein Kinases Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- 206010041067 Small cell lung cancer Diseases 0.000 description 2
- 108091023040 Transcription factor Proteins 0.000 description 2
- 102000040945 Transcription factor Human genes 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 150000001413 amino acids Chemical group 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 208000019065 cervical carcinoma Diseases 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000010468 interferon response Effects 0.000 description 2
- 208000020082 intraepithelial neoplasia Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 2
- 238000011580 nude mouse model Methods 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 208000000587 small cell lung carcinoma Diseases 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229940021747 therapeutic vaccine Drugs 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 2
- 230000006490 viral transcription Effects 0.000 description 2
- ZFGXZJKLOFCECI-UHFFFAOYSA-N 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]phenol Chemical compound C1=CC(O)=CC=C1NC1=NC(C=2C=CC(Cl)=CC=2)=CS1 ZFGXZJKLOFCECI-UHFFFAOYSA-N 0.000 description 1
- 235000003625 Acrocomia mexicana Nutrition 0.000 description 1
- 244000202285 Acrocomia mexicana Species 0.000 description 1
- 244000005894 Albizia lebbeck Species 0.000 description 1
- 206010059313 Anogenital warts Diseases 0.000 description 1
- 241000269350 Anura Species 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 101150013359 E7 gene Proteins 0.000 description 1
- 241000724791 Filamentous phage Species 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000868422 Homo sapiens Sushi, nidogen and EGF-like domain-containing protein 1 Proteins 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 102000006992 Interferon-alpha Human genes 0.000 description 1
- 108010047761 Interferon-alpha Proteins 0.000 description 1
- 101710128836 Large T antigen Proteins 0.000 description 1
- 102000043129 MHC class I family Human genes 0.000 description 1
- 108091054437 MHC class I family Proteins 0.000 description 1
- 206010064912 Malignant transformation Diseases 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 101000726081 Mus musculus Cysteine-rich secretory protein 3 Proteins 0.000 description 1
- 241001233384 Negha Species 0.000 description 1
- 206010061309 Neoplasm progression Diseases 0.000 description 1
- 244000004005 Nypa fruticans Species 0.000 description 1
- 235000005305 Nypa fruticans Nutrition 0.000 description 1
- 241000468053 Obodhiang virus Species 0.000 description 1
- 241000283965 Ochotona princeps Species 0.000 description 1
- 241000425481 Ocys Species 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 241000514450 Podocarpus latifolius Species 0.000 description 1
- 206010038707 Respiratory papilloma Diseases 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102100032853 Sushi, nidogen and EGF-like domain-containing protein 1 Human genes 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 1
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 1
- 108010049024 Viral Oncogene Proteins Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 101001076308 Xenopus laevis Insulin-like growth factor III Proteins 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 231100000005 chromosome aberration Toxicity 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000000326 densiometry Methods 0.000 description 1
- 231100000276 dose-dependent cytotoxicity Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000000367 immunologic factor Substances 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 230000036212 malign transformation Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 1
- 231100001222 nononcogenic Toxicity 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 108010043655 penetratin Proteins 0.000 description 1
- MCYTYTUNNNZWOK-LCLOTLQISA-N penetratin Chemical compound C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=CC=C1 MCYTYTUNNNZWOK-LCLOTLQISA-N 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 108091005981 phosphorylated proteins Proteins 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 229940021993 prophylactic vaccine Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000000754 repressing effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003153 stable transfection Methods 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 108010062760 transportan Proteins 0.000 description 1
- PBKWZFANFUTEPS-CWUSWOHSSA-N transportan Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CC=C(O)C=C1 PBKWZFANFUTEPS-CWUSWOHSSA-N 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20010309A CU23225A1 (es) | 2001-12-20 | 2001-12-20 | PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES |
| PCT/CU2002/000010 WO2003054002A1 (es) | 2001-12-20 | 2002-12-04 | Péptidos para el tratamiento del cáncer asociado al virus papiloma humano (vph) y de otros tumores epiteliales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA81403C2 true UA81403C2 (en) | 2008-01-10 |
Family
ID=40091679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20040705927A UA81403C2 (en) | 2001-12-20 | 2002-04-12 | Peptide capable to bind casein kinase ii (ckii) phosphorylating site and to inhibit phosphorylation and use thereof |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US7374767B2 (zh) |
| EP (2) | EP1491553B1 (zh) |
| JP (1) | JP4056476B2 (zh) |
| KR (1) | KR100642437B1 (zh) |
| CN (1) | CN100368431C (zh) |
| AR (1) | AR037825A1 (zh) |
| AT (1) | ATE520704T1 (zh) |
| AU (1) | AU2002361922B2 (zh) |
| BR (1) | BRPI0215213C1 (zh) |
| CA (1) | CA2471110C (zh) |
| CR (1) | CR7361A (zh) |
| CU (1) | CU23225A1 (zh) |
| DK (1) | DK1491553T3 (zh) |
| DO (1) | DOP2002000548A (zh) |
| ES (1) | ES2371239T3 (zh) |
| HK (1) | HK1068901A1 (zh) |
| HN (1) | HN2002000377A (zh) |
| HR (1) | HRP20040663B1 (zh) |
| IL (2) | IL162633A0 (zh) |
| IS (1) | IS2906B (zh) |
| MA (1) | MA27868A1 (zh) |
| MX (1) | MXPA04005832A (zh) |
| MY (1) | MY133530A (zh) |
| NO (1) | NO333259B1 (zh) |
| NZ (1) | NZ534170A (zh) |
| PE (1) | PE20030861A1 (zh) |
| PT (1) | PT1491553E (zh) |
| RU (1) | RU2290410C2 (zh) |
| SI (1) | SI1491553T1 (zh) |
| TN (1) | TNSN04114A1 (zh) |
| UA (1) | UA81403C2 (zh) |
| UY (1) | UY27602A1 (zh) |
| WO (1) | WO2003054002A1 (zh) |
| ZA (1) | ZA200405514B (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU23225A1 (es) * | 2001-12-20 | 2007-08-30 | Ct Ingenieria Genetica Biotech | PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES |
| CU23431B6 (es) * | 2005-05-12 | 2009-10-16 | Ct Ingenieria Genetica Biotech | Método para la inhibición de la proliferación de células tumorales y el tratamiento del cáncer |
| GB2433740A (en) * | 2005-12-23 | 2007-07-04 | Rapid Biosensor Systems Ltd | Detection of tuberculosis infection |
| CU23511B6 (es) * | 2006-02-28 | 2010-04-13 | Biorec B V | Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas |
| GB2441131A (en) * | 2006-08-24 | 2008-02-27 | Univ Dundee | Modulation of binding of CK2a to NDPK |
| CN100522992C (zh) * | 2007-02-12 | 2009-08-05 | 中国科学院昆明动物研究所 | 一种环状小肽ba |
| US20110052725A1 (en) * | 2007-03-27 | 2011-03-03 | Takashi Shibata | Therapeutic agent for infectious skin and mucosal disease |
| US20110305706A1 (en) | 2009-02-23 | 2011-12-15 | Scott Thomas Brady | Compositions and Methods for Treating a Disease Mediated by Soluble Oligomeric Amyloid Beta |
| CN102625842A (zh) * | 2009-03-13 | 2012-08-01 | 艾根股份有限公司 | 用于输送生物活性rna的组合物和方法 |
| EP3397276A4 (en) | 2015-12-30 | 2019-12-18 | Kodiak Sciences Inc. | ANTIBODIES AND CONJUGATES THEREOF |
| CU20200103A7 (es) * | 2020-12-18 | 2022-07-08 | Ct Ingenieria Genetica Biotecnologia | Péptido sintético para la inducción de inmunidad antitumoral y antiviral |
| CU20210058A7 (es) | 2021-07-09 | 2023-02-13 | Ct Ingenieria Genetica Biotecnologia | Péptidos lineales que inhiben la fosforilación mediada por ck2 y composiciones que los comprenden |
| CN118370805A (zh) * | 2024-04-29 | 2024-07-23 | 广州美达康生物医药科技有限公司 | 一种抑菌妇科凝胶及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE902820A1 (en) * | 1989-08-07 | 1991-02-27 | Merck & Co Inc | Peptide inhibitors of human papilloma virus protein binding¹to retinoblastoma gene proteins |
| JPH05310784A (ja) * | 1991-09-04 | 1993-11-22 | Merck & Co Inc | ヒト乳頭腫ウイルスタンパク質と網膜芽細胞腫遺伝子タンパク質との結合のペプチド阻害剤 |
| GB9313556D0 (en) | 1993-07-01 | 1993-08-18 | British Tech Group | Synthetic peptides of human papillomavirus |
| US5625031A (en) | 1994-02-08 | 1997-04-29 | Bristol-Myers Squibb Company | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein |
| ATE235509T1 (de) * | 1998-06-30 | 2003-04-15 | Deutsches Krebsforsch | Peptide zur inhibition von hpv e7 proteinen |
| US6641994B2 (en) * | 1999-08-25 | 2003-11-04 | Pharmacia & Upjohn Company | Methods of identifying anti-viral agents |
| AU2001238347A1 (en) * | 2000-02-28 | 2001-09-12 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| CU23225A1 (es) * | 2001-12-20 | 2007-08-30 | Ct Ingenieria Genetica Biotech | PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES |
-
2001
- 2001-12-20 CU CU20010309A patent/CU23225A1/es unknown
-
2002
- 2002-04-12 UA UA20040705927A patent/UA81403C2/uk unknown
- 2002-12-04 CN CNB028282698A patent/CN100368431C/zh not_active Expired - Lifetime
- 2002-12-04 BR BRPI0215213A patent/BRPI0215213C1/pt not_active IP Right Cessation
- 2002-12-04 KR KR1020047009771A patent/KR100642437B1/ko active IP Right Grant
- 2002-12-04 SI SI200230967T patent/SI1491553T1/sl unknown
- 2002-12-04 IL IL16263302A patent/IL162633A0/xx active IP Right Grant
- 2002-12-04 PT PT02796490T patent/PT1491553E/pt unknown
- 2002-12-04 AU AU2002361922A patent/AU2002361922B2/en not_active Ceased
- 2002-12-04 AT AT02796490T patent/ATE520704T1/de active
- 2002-12-04 NZ NZ534170A patent/NZ534170A/en not_active IP Right Cessation
- 2002-12-04 ES ES02796490T patent/ES2371239T3/es not_active Expired - Lifetime
- 2002-12-04 CA CA2471110A patent/CA2471110C/en not_active Expired - Lifetime
- 2002-12-04 JP JP2003554718A patent/JP4056476B2/ja not_active Expired - Fee Related
- 2002-12-04 EP EP02796490A patent/EP1491553B1/en not_active Expired - Lifetime
- 2002-12-04 RU RU2004122084/13A patent/RU2290410C2/ru active
- 2002-12-04 US US10/499,458 patent/US7374767B2/en not_active Expired - Lifetime
- 2002-12-04 MX MXPA04005832A patent/MXPA04005832A/es active IP Right Grant
- 2002-12-04 EP EP11168526A patent/EP2383282A1/en not_active Ceased
- 2002-12-04 DK DK02796490.7T patent/DK1491553T3/da active
- 2002-12-04 WO PCT/CU2002/000010 patent/WO2003054002A1/es active IP Right Grant
- 2002-12-11 MY MYPI20024638A patent/MY133530A/en unknown
- 2002-12-13 AR ARP020104844A patent/AR037825A1/es not_active Application Discontinuation
- 2002-12-17 DO DO2002000548A patent/DOP2002000548A/es unknown
- 2002-12-19 HN HN2002000377A patent/HN2002000377A/es unknown
- 2002-12-20 UY UY27602A patent/UY27602A1/es active IP Right Grant
-
2003
- 2003-01-06 PE PE2003000006A patent/PE20030861A1/es not_active Application Discontinuation
-
2004
- 2004-06-04 CR CR7361A patent/CR7361A/es unknown
- 2004-06-15 MA MA27740A patent/MA27868A1/fr unknown
- 2004-06-16 IS IS7320A patent/IS2906B/is unknown
- 2004-06-17 TN TNP2004000114A patent/TNSN04114A1/en unknown
- 2004-06-20 IL IL162633A patent/IL162633A/en not_active IP Right Cessation
- 2004-07-12 ZA ZA2004/05514A patent/ZA200405514B/en unknown
- 2004-07-19 HR HRP20040663AA patent/HRP20040663B1/hr not_active IP Right Cessation
- 2004-07-20 NO NO20043112A patent/NO333259B1/no not_active IP Right Cessation
-
2005
- 2005-02-24 HK HK05101552.3A patent/HK1068901A1/xx not_active IP Right Cessation
-
2008
- 2008-04-08 US US12/099,646 patent/US7947287B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7947287B2 (en) | Peptides for the treatment of cancer associated with the human papilloma virus (HPV) and other epithelial tumors | |
| Herbein et al. | Polyploid giant cancer cells, a hallmark of oncoviruses and a new therapeutic challenge | |
| Van der Watt et al. | The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation | |
| Koromilas et al. | Control of interferon signaling in human papillomavirus infection | |
| Yi et al. | Epstein–Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities | |
| Pappa et al. | Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer | |
| US20040171806A1 (en) | Modified hpv e6 and e7 genes and proteins useful for vaccination | |
| Lee et al. | Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity | |
| Chung et al. | Myristylation and polylysine-mediated activation of the protein kinase domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) | |
| Brown et al. | Marek’s disease virus oncoprotein Meq physically interacts with the chicken infectious anemia virus-encoded apoptotic protein apoptin | |
| Akita et al. | p21WAF1 modulates NF-κB signaling and induces anti-apoptotic protein Bcl-2 in Tax-expressing rat fibroblast | |
| JP7483227B2 (ja) | Ｐｄ－１シグナル配列を有する抗腫瘍ペプチドおよびその利用 | |
| Sahu et al. | Epstein–Barr virus nuclear antigen 3C interact with p73: Interplay between a viral oncoprotein and cellular tumor suppressor | |
| Massimi et al. | Regulation of the human papillomavirus oncoproteins by differential phosphorylation | |
| JP2021004178A (ja) | 抗腫瘍ペプチドおよびその利用 | |
| Fang et al. | Modulation of Epstein-Barr virus latent membrane protein 1 activity by intrabodies | |
| CN107485716B (zh) | 可运载功能性分子进入hsv可感染细胞的载体及药物 | |
| WO1990013565A1 (en) | A method for detecting precancerous and cancerous cervical intraepithelium | |
| CA2455681A1 (en) | An inducer of apoptosis | |
| Alfaifi | The Influence of HPV16 E6 Oncoprotein on the Radiation Resistance of Cervical Cancer | |
| Kooistra et al. | Viral apoptosis inducer apoptin senses cell-type dependent nuclear trafficking of the transforming SV40 large T antigen | |
| Xu | Interaction of herpesvirus immediate-early proteins with components of intranuclear subcompartments | |
| Massimi | Functional Studies of the Human Papillomavirus E7 Protein | |
| Noya | Modulation of S-phase re-entry in differentiated keratinocytes by the human papillomavirus E7 gene |