UA79776C2 - Hfa-suspension formulation of crystalline tiotropium bromide anhydrate and use thereof - Google Patents

Hfa-suspension formulation of crystalline tiotropium bromide anhydrate and use thereof Download PDF

Info

Publication number
UA79776C2
UA79776C2 UA20041008758A UA20041008758A UA79776C2 UA 79776 C2 UA79776 C2 UA 79776C2 UA 20041008758 A UA20041008758 A UA 20041008758A UA 20041008758 A UA20041008758 A UA 20041008758A UA 79776 C2 UA79776 C2 UA 79776C2
Authority
UA
Ukraine
Prior art keywords
acid
suspension according
tiotropium
tiotropium bromide
glyceryl
Prior art date
Application number
UA20041008758A
Other languages
English (en)
Ukrainian (uk)
Inventor
Christel Schmelzer
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of UA79776C2 publication Critical patent/UA79776C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
UA20041008758A 2002-03-28 2003-03-20 Hfa-suspension formulation of crystalline tiotropium bromide anhydrate and use thereof UA79776C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10214264A DE10214264A1 (de) 2002-03-28 2002-03-28 HFA-Suspensionsformulierungen eines Anhydrats
PCT/EP2003/002899 WO2003082244A2 (de) 2002-03-28 2003-03-20 Hfa-suspensionsformulierungen eines anhydrats

Publications (1)

Publication Number Publication Date
UA79776C2 true UA79776C2 (en) 2007-07-25

Family

ID=28050990

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20041008758A UA79776C2 (en) 2002-03-28 2003-03-20 Hfa-suspension formulation of crystalline tiotropium bromide anhydrate and use thereof

Country Status (21)

Country Link
EP (1) EP1492498A2 (de)
JP (1) JP5147158B2 (de)
KR (1) KR101005717B1 (de)
CN (1) CN1642525A (de)
AU (1) AU2003221509B2 (de)
BR (1) BR0308709A (de)
CA (1) CA2479638C (de)
DE (1) DE10214264A1 (de)
EA (1) EA008610B1 (de)
EC (1) ECSP045322A (de)
HR (1) HRP20040890A2 (de)
IL (1) IL163696A0 (de)
ME (1) ME00246B (de)
MX (1) MXPA04009338A (de)
NO (1) NO20044004L (de)
NZ (1) NZ536030A (de)
PL (1) PL371295A1 (de)
RS (1) RS52481B (de)
UA (1) UA79776C2 (de)
WO (1) WO2003082244A2 (de)
ZA (1) ZA200405637B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007144531A (ru) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые кристаллические формы тиотропийбромида
RU2417224C2 (ru) * 2005-05-02 2011-04-27 Бёрингер Ингельхайм Интернациональ Гмбх Новые кристаллические формы тиотропийбромида
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
AU2015201037C1 (en) * 2009-05-29 2017-07-27 Pearl Therapeutics, Inc. Respiratory delivery of active agents
PT3111927T (pt) 2009-05-29 2020-03-03 Pearl Therapeutics Inc Composições para administração respiratória de agentes ativos e métodos e sistemas associados
TR201902687T4 (tr) 2013-03-15 2019-03-21 Pearl Therapeutics Inc İri parçacıklı kristal malzemelerin koşullandırılması için yöntemler ve sistemler.
JP6781831B2 (ja) * 2016-09-19 2020-11-04 メキシケム フロー エセ・ア・デ・セ・ヴェ 医薬組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CA2338680C (en) * 1998-08-04 2008-10-14 Jago Research Ag Medicinal aerosol formulations
GB0009606D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic combinations
GB0009605D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medicaments
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009583D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory formulations
CA2436537C (en) * 2000-10-31 2009-05-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions comprising tiotropium salts and antihistamines
DE10111058A1 (de) * 2001-03-08 2002-09-12 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und NK¶1¶-Rezeptor-Antagonisten
DE10113366A1 (de) * 2001-03-20 2002-09-26 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Endothelinantagonisten

Also Published As

Publication number Publication date
MXPA04009338A (es) 2005-01-25
ZA200405637B (en) 2005-07-27
WO2003082244A3 (de) 2004-02-05
ME00246B (de) 2011-05-10
NZ536030A (en) 2006-07-28
BR0308709A (pt) 2005-01-04
RS52481B (sr) 2013-02-28
KR101005717B1 (ko) 2011-01-05
EP1492498A2 (de) 2005-01-05
IL163696A0 (en) 2005-12-18
CA2479638C (en) 2011-01-04
YU86004A (sh) 2006-08-17
DE10214264A1 (de) 2003-10-16
JP5147158B2 (ja) 2013-02-20
JP2005527550A (ja) 2005-09-15
MEP47308A (en) 2011-02-10
EA008610B1 (ru) 2007-06-29
PL371295A1 (en) 2005-06-13
EA200401159A1 (ru) 2005-04-28
CN1642525A (zh) 2005-07-20
AU2003221509A1 (en) 2003-10-13
KR20040098022A (ko) 2004-11-18
CA2479638A1 (en) 2003-10-09
HRP20040890A2 (en) 2005-06-30
AU2003221509B2 (en) 2008-01-24
NO20044004L (no) 2004-10-05
WO2003082244A2 (de) 2003-10-09
ECSP045322A (es) 2005-01-28

Similar Documents

Publication Publication Date Title
US7736627B2 (en) HFA suspension formulations containing an anticholinergic
MXPA03003221A (es) Monohidrato cristalino, procedmiento para su preparacion y su uso para la preparacion de un medicamento.
AU2018303782B9 (en) New crystalline forms of vilanterol trifenatate and processes for their preparation
UA79776C2 (en) Hfa-suspension formulation of crystalline tiotropium bromide anhydrate and use thereof
UA82413C2 (uk) Спосіб одержання солей тіотропію, солі тіотропію, а також лікарський засіб, який їх містить
UA78557C2 (en) Propellant gas formulation containing suspension of thiotropium bromide monohydrate
US7244415B2 (en) HFA suspension formulations of an anhydrate