UA78529C2 - Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain - Google Patents

Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain Download PDF

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Publication number
UA78529C2
UA78529C2 UA20040503402A UA20040503402A UA78529C2 UA 78529 C2 UA78529 C2 UA 78529C2 UA 20040503402 A UA20040503402 A UA 20040503402A UA 20040503402 A UA20040503402 A UA 20040503402A UA 78529 C2 UA78529 C2 UA 78529C2
Authority
UA
Ukraine
Prior art keywords
pain
dioxo
carbon atoms
diazabicyclo
formula
Prior art date
Application number
UA20040503402A
Other languages
English (en)
Ukrainian (uk)
Inventor
Michael Richard Brandt
Margaret Maria Zaleska
John Allen Moyer
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of UA78529C2 publication Critical patent/UA78529C2/uk

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
UA20040503402A 2001-10-10 2002-09-10 Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain UA78529C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32824501P 2001-10-10 2001-10-10
PCT/US2002/032252 WO2003031416A2 (en) 2001-10-10 2002-10-09 [[2-(amino-3,4-dioxo-1cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain

Publications (1)

Publication Number Publication Date
UA78529C2 true UA78529C2 (en) 2007-04-10

Family

ID=23280159

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20040503402A UA78529C2 (en) 2001-10-10 2002-09-10 Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain

Country Status (27)

Country Link
US (2) US7098200B2 (ja)
EP (1) EP1434588B1 (ja)
JP (1) JP4350512B2 (ja)
KR (1) KR100922703B1 (ja)
CN (1) CN100448449C (ja)
AR (1) AR036764A1 (ja)
AT (1) ATE515266T1 (ja)
AU (1) AU2009201746A1 (ja)
BR (1) BR0213237A (ja)
CA (1) CA2461348C (ja)
CY (1) CY1111909T1 (ja)
DK (1) DK1434588T3 (ja)
EA (1) EA009993B1 (ja)
ES (1) ES2367356T3 (ja)
HK (1) HK1064609A1 (ja)
HU (1) HUP0401773A3 (ja)
IL (2) IL161275A0 (ja)
MX (1) MXPA04003354A (ja)
NO (1) NO20041378L (ja)
NZ (1) NZ532159A (ja)
PL (1) PL368863A1 (ja)
PT (1) PT1434588E (ja)
SI (1) SI1434588T1 (ja)
TW (1) TWI321472B (ja)
UA (1) UA78529C2 (ja)
WO (1) WO2003031416A2 (ja)
ZA (1) ZA200403406B (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE391498T1 (de) * 2002-11-22 2008-04-15 Gruenenthal Gmbh Verwendung von (1rs,3rs,6rs)-6- dimethylaminomethyl-1-(3-methoxy-phenyl)- cyclohexan-1,3-diol zur behandlung von entzündungsschmerz
MXPA05010763A (es) * 2003-04-09 2005-12-12 Wyeth Corp Composiciones farmaceuticas para administracion intranasal de acido [2-(8, 9-dioxo-2, 6-diazabiciclo [5.2.0] non-1(7) -en-2-il) alquil- fosfonico] y metodos de uso del mismo.
ATE481103T1 (de) 2003-04-09 2010-10-15 Wyeth Llc Derivate von 2-(8,9-dioxo-2,6- diazabicyclo(5.2.0)non-1(7)-en-2- yl)alkylphosphonsäure und deren verwendung als n- methyl-d-aspartat- (nmda-) rezeptorantagonisten
US20050142192A1 (en) * 2003-10-15 2005-06-30 Wyeth Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
TW200514775A (en) * 2003-10-22 2005-05-01 Wyeth Corp Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
JP2008515904A (ja) * 2004-10-08 2008-05-15 ワイス [2−(8,9−ジオキソ−2,6−ジアザビシクロ[5.2.0]ノン−1(7)−エン−2−イル)アルキル]ホスホン酸の誘導体およびその製造方法
KR20100049663A (ko) * 2007-08-27 2010-05-12 와이어쓰 엘엘씨 마취제-절감 효과를 달성하기 위해 nmda 길항제를 사용하는 조성물 및 방법
DK3566703T3 (da) * 2009-02-13 2021-07-05 Allergan Inc Farmaceutiske sammensætninger omfattende (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
KR20110139274A (ko) 2009-03-19 2011-12-28 와이어쓰 엘엘씨 [2-(8,9-다이옥소-2,6-다이아자바이사이클로[5.2.0]논-1(7)-엔-2-일)에틸]포스폰산 및 이의 전구체의 제조 방법
WO2013078151A1 (en) 2011-11-21 2013-05-30 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
WO2015149066A1 (en) * 2014-03-28 2015-10-01 University Of Virginia Patent Foundation General anesthetics that are not neurotoxic

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168103A (en) * 1991-01-22 1992-12-01 American Home Products Corporation [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives
US5124319A (en) 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids
DK124393D0 (da) * 1993-11-03 1993-11-03 Lundbeck & Co As H Compounds
AT400440B (de) * 1993-12-06 1995-12-27 Vianova Kunstharz Ag Verfahren zur herstellung von wasserverdünnbaren lackbindemitteln und deren verwendung
TW427904B (en) * 1995-12-07 2001-04-01 American Home Prod Neuroprotective agents
UA52698C2 (uk) * 1996-10-04 2003-01-15 Х. Луннбек А/С Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі
IL134082A0 (en) 1997-08-01 2001-04-30 American Home Prod Process for the preparation of [2-((8,9)-dioxo-2,6-diazabicyclo[5,2.0]-non-1(7)-en-2-yl)-ethyl]-phosphonic acid
US5990307A (en) 1997-08-01 1999-11-23 American Home Products Corporation Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid
US6362371B1 (en) 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
US6225343B1 (en) 1999-06-16 2001-05-01 Nastech Pharmaceutical Company, Inc. Compositions and methods comprising morphine gluconate
US20030158254A1 (en) 2002-01-24 2003-08-21 Xenoport, Inc. Engineering absorption of therapeutic compounds via colonic transporters
US20040082543A1 (en) 2002-10-29 2004-04-29 Pharmacia Corporation Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain

Also Published As

Publication number Publication date
EA009993B1 (ru) 2008-06-30
CA2461348A1 (en) 2003-04-17
EP1434588B1 (en) 2011-07-06
CN1568189A (zh) 2005-01-19
US7759346B2 (en) 2010-07-20
NO20041378L (no) 2004-05-28
SI1434588T1 (sl) 2011-10-28
HK1064609A1 (en) 2005-02-04
MXPA04003354A (es) 2004-09-28
IL161275A (en) 2009-09-01
ES2367356T3 (es) 2011-11-02
CN100448449C (zh) 2009-01-07
TWI321472B (en) 2010-03-11
ATE515266T1 (de) 2011-07-15
KR20050034604A (ko) 2005-04-14
NZ532159A (en) 2006-02-24
HUP0401773A3 (en) 2005-06-28
JP2005508950A (ja) 2005-04-07
KR100922703B1 (ko) 2009-10-22
US7098200B2 (en) 2006-08-29
BR0213237A (pt) 2004-09-28
EP1434588A2 (en) 2004-07-07
AU2009201746A1 (en) 2009-05-28
US20030114444A1 (en) 2003-06-19
US20060205696A1 (en) 2006-09-14
JP4350512B2 (ja) 2009-10-21
IL161275A0 (en) 2004-09-27
WO2003031416A3 (en) 2003-08-14
PL368863A1 (en) 2005-04-04
CY1111909T1 (el) 2015-11-04
AR036764A1 (es) 2004-09-29
WO2003031416A2 (en) 2003-04-17
PT1434588E (pt) 2011-09-05
EA200400523A1 (ru) 2004-08-26
HUP0401773A2 (hu) 2005-01-28
ZA200403406B (en) 2007-04-25
CA2461348C (en) 2011-02-15
DK1434588T3 (da) 2011-08-15

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