UA78529C2 - Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain - Google Patents
Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain Download PDFInfo
- Publication number
- UA78529C2 UA78529C2 UA20040503402A UA20040503402A UA78529C2 UA 78529 C2 UA78529 C2 UA 78529C2 UA 20040503402 A UA20040503402 A UA 20040503402A UA 20040503402 A UA20040503402 A UA 20040503402A UA 78529 C2 UA78529 C2 UA 78529C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pain
- dioxo
- carbon atoms
- diazabicyclo
- formula
- Prior art date
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Public Health (AREA)
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- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US32824501P | 2001-10-10 | 2001-10-10 | |
PCT/US2002/032252 WO2003031416A2 (en) | 2001-10-10 | 2002-10-09 | [[2-(amino-3,4-dioxo-1cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain |
Publications (1)
Publication Number | Publication Date |
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UA78529C2 true UA78529C2 (en) | 2007-04-10 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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UA20040503402A UA78529C2 (en) | 2001-10-10 | 2002-09-10 | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
Country Status (27)
Country | Link |
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US (2) | US7098200B2 (ja) |
EP (1) | EP1434588B1 (ja) |
JP (1) | JP4350512B2 (ja) |
KR (1) | KR100922703B1 (ja) |
CN (1) | CN100448449C (ja) |
AR (1) | AR036764A1 (ja) |
AT (1) | ATE515266T1 (ja) |
AU (1) | AU2009201746A1 (ja) |
BR (1) | BR0213237A (ja) |
CA (1) | CA2461348C (ja) |
CY (1) | CY1111909T1 (ja) |
DK (1) | DK1434588T3 (ja) |
EA (1) | EA009993B1 (ja) |
ES (1) | ES2367356T3 (ja) |
HK (1) | HK1064609A1 (ja) |
HU (1) | HUP0401773A3 (ja) |
IL (2) | IL161275A0 (ja) |
MX (1) | MXPA04003354A (ja) |
NO (1) | NO20041378L (ja) |
NZ (1) | NZ532159A (ja) |
PL (1) | PL368863A1 (ja) |
PT (1) | PT1434588E (ja) |
SI (1) | SI1434588T1 (ja) |
TW (1) | TWI321472B (ja) |
UA (1) | UA78529C2 (ja) |
WO (1) | WO2003031416A2 (ja) |
ZA (1) | ZA200403406B (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE391498T1 (de) * | 2002-11-22 | 2008-04-15 | Gruenenthal Gmbh | Verwendung von (1rs,3rs,6rs)-6- dimethylaminomethyl-1-(3-methoxy-phenyl)- cyclohexan-1,3-diol zur behandlung von entzündungsschmerz |
MXPA05010763A (es) * | 2003-04-09 | 2005-12-12 | Wyeth Corp | Composiciones farmaceuticas para administracion intranasal de acido [2-(8, 9-dioxo-2, 6-diazabiciclo [5.2.0] non-1(7) -en-2-il) alquil- fosfonico] y metodos de uso del mismo. |
ATE481103T1 (de) | 2003-04-09 | 2010-10-15 | Wyeth Llc | Derivate von 2-(8,9-dioxo-2,6- diazabicyclo(5.2.0)non-1(7)-en-2- yl)alkylphosphonsäure und deren verwendung als n- methyl-d-aspartat- (nmda-) rezeptorantagonisten |
US20050142192A1 (en) * | 2003-10-15 | 2005-06-30 | Wyeth | Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives |
TW200514775A (en) * | 2003-10-22 | 2005-05-01 | Wyeth Corp | Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof |
JP2008515904A (ja) * | 2004-10-08 | 2008-05-15 | ワイス | [2−(8,9−ジオキソ−2,6−ジアザビシクロ[5.2.0]ノン−1(7)−エン−2−イル)アルキル]ホスホン酸の誘導体およびその製造方法 |
KR20100049663A (ko) * | 2007-08-27 | 2010-05-12 | 와이어쓰 엘엘씨 | 마취제-절감 효과를 달성하기 위해 nmda 길항제를 사용하는 조성물 및 방법 |
DK3566703T3 (da) * | 2009-02-13 | 2021-07-05 | Allergan Inc | Farmaceutiske sammensætninger omfattende (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol |
KR20110139274A (ko) | 2009-03-19 | 2011-12-28 | 와이어쓰 엘엘씨 | [2-(8,9-다이옥소-2,6-다이아자바이사이클로[5.2.0]논-1(7)-엔-2-일)에틸]포스폰산 및 이의 전구체의 제조 방법 |
WO2013078151A1 (en) | 2011-11-21 | 2013-05-30 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
WO2015149066A1 (en) * | 2014-03-28 | 2015-10-01 | University Of Virginia Patent Foundation | General anesthetics that are not neurotoxic |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5168103A (en) * | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
US5124319A (en) | 1991-10-11 | 1992-06-23 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
DK124393D0 (da) * | 1993-11-03 | 1993-11-03 | Lundbeck & Co As H | Compounds |
AT400440B (de) * | 1993-12-06 | 1995-12-27 | Vianova Kunstharz Ag | Verfahren zur herstellung von wasserverdünnbaren lackbindemitteln und deren verwendung |
TW427904B (en) * | 1995-12-07 | 2001-04-01 | American Home Prod | Neuroprotective agents |
UA52698C2 (uk) * | 1996-10-04 | 2003-01-15 | Х. Луннбек А/С | Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі |
IL134082A0 (en) | 1997-08-01 | 2001-04-30 | American Home Prod | Process for the preparation of [2-((8,9)-dioxo-2,6-diazabicyclo[5,2.0]-non-1(7)-en-2-yl)-ethyl]-phosphonic acid |
US5990307A (en) | 1997-08-01 | 1999-11-23 | American Home Products Corporation | Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid |
US6362371B1 (en) | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
US6225343B1 (en) | 1999-06-16 | 2001-05-01 | Nastech Pharmaceutical Company, Inc. | Compositions and methods comprising morphine gluconate |
US20030158254A1 (en) | 2002-01-24 | 2003-08-21 | Xenoport, Inc. | Engineering absorption of therapeutic compounds via colonic transporters |
US20040082543A1 (en) | 2002-10-29 | 2004-04-29 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain |
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