UA78312C2 - Heterotricyclyl 6-alkyliden-penems as beta-lactamase inhibitors - Google Patents
Heterotricyclyl 6-alkyliden-penems as beta-lactamase inhibitors Download PDFInfo
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- UA78312C2 UA78312C2 UA20041109780A UA20041109780A UA78312C2 UA 78312 C2 UA78312 C2 UA 78312C2 UA 20041109780 A UA20041109780 A UA 20041109780A UA 20041109780 A UA20041109780 A UA 20041109780A UA 78312 C2 UA78312 C2 UA 78312C2
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- 239000003781 beta lactamase inhibitor Substances 0.000 title description 2
- 229940126813 beta-lactamase inhibitor Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 130
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 229910052799 carbon Inorganic materials 0.000 claims description 423
- 230000015572 biosynthetic process Effects 0.000 claims description 332
- 229920006395 saturated elastomer Polymers 0.000 claims description 219
- FYZUENZXIZCLAZ-UHFFFAOYSA-N 2-methylhept-2-enoic acid Chemical compound CCCCC=C(C)C(O)=O FYZUENZXIZCLAZ-UHFFFAOYSA-N 0.000 claims description 93
- 125000001072 heteroaryl group Chemical group 0.000 claims description 57
- 159000000000 sodium salts Chemical class 0.000 claims description 51
- 125000004432 carbon atom Chemical group C* 0.000 claims description 42
- 238000000034 method Methods 0.000 claims description 36
- -1 substituted Chemical class 0.000 claims description 31
- 125000004190 benzothiazol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N=C(*)SC2=C1[H] 0.000 claims description 29
- 125000005842 heteroatom Chemical group 0.000 claims description 20
- 239000001257 hydrogen Substances 0.000 claims description 17
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 17
- 229910052796 boron Inorganic materials 0.000 claims description 16
- 229910052760 oxygen Inorganic materials 0.000 claims description 14
- 125000003107 substituted aryl group Chemical group 0.000 claims description 14
- 230000003115 biocidal effect Effects 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 12
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- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims description 8
- 150000002148 esters Chemical class 0.000 claims description 8
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- 125000006239 protecting group Chemical group 0.000 claims description 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 7
- 125000004122 cyclic group Chemical group 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 6
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 6
- 125000004260 quinazolin-2-yl group Chemical group [H]C1=NC(*)=NC2=C1C([H])=C([H])C([H])=C2[H] 0.000 claims description 6
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims description 6
- 125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims description 5
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- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37705102P | 2002-05-01 | 2002-05-01 | |
| PCT/US2003/013451 WO2003093280A1 (en) | 2002-05-01 | 2003-04-30 | Heterotricyclyl 6-alkylidene-penems as βετα-lactamase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA78312C2 true UA78312C2 (en) | 2007-03-15 |
Family
ID=29401436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20041109780A UA78312C2 (en) | 2002-05-01 | 2003-04-30 | Heterotricyclyl 6-alkyliden-penems as beta-lactamase inhibitors |
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|---|---|
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| JP (1) | JP4472515B2 (enExample) |
| KR (1) | KR20050007366A (enExample) |
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| AT (1) | ATE425169T1 (enExample) |
| AU (1) | AU2003239325B8 (enExample) |
| BR (1) | BR0309878A (enExample) |
| CA (1) | CA2483562C (enExample) |
| DE (1) | DE60326562D1 (enExample) |
| DK (1) | DK1499622T3 (enExample) |
| EC (1) | ECSP045405A (enExample) |
| ES (1) | ES2322951T3 (enExample) |
| IL (1) | IL164898A0 (enExample) |
| MX (1) | MXPA04010662A (enExample) |
| NO (1) | NO20044550L (enExample) |
| NZ (1) | NZ536181A (enExample) |
| RU (1) | RU2004135086A (enExample) |
| TW (1) | TW200404809A (enExample) |
| UA (1) | UA78312C2 (enExample) |
| WO (1) | WO2003093280A1 (enExample) |
| ZA (1) | ZA200409691B (enExample) |
Families Citing this family (12)
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|---|---|---|---|---|
| US20040132708A1 (en) * | 2002-05-01 | 2004-07-08 | Wyeth | Process for preparing 6-alkylidene penem derivatives |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| AR039476A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | Proceso para preparar derivados de 6-alquiliden penem |
| AR039475A1 (es) | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| TW200716104A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| TW200716102A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| AU2006285308A1 (en) * | 2005-07-27 | 2007-03-08 | Wyeth | Tricyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic |
| RU2008102912A (ru) * | 2005-07-27 | 2009-09-10 | Вайет (Us) | Сочетание ингибиторов бетта-лактазмы бициклического 6-алкилиденпенема с бетта-лактанным антибиотиком: антибиотик широкого спектра |
| GT200600380A (es) * | 2005-08-24 | 2007-03-29 | Proceso para la preparacion de inhibidores de beta-lactamasa | |
| US20100063023A1 (en) * | 2008-09-10 | 2010-03-11 | Wyeth | Bicyclic and Tricyclic Substituted 6-Methylidene Carbapenems as Broad Spectrum Beta-Lactamase Inhibitors |
| US20110288063A1 (en) * | 2010-05-19 | 2011-11-24 | Naeja Pharmaceutical Inc. | Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors |
| KR20240036571A (ko) | 2021-07-15 | 2024-03-20 | 제넨테크, 인크. | 치료 화합물 및 방법 |
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-
2003
- 2003-04-28 AR ARP030101469A patent/AR039475A1/es not_active Application Discontinuation
- 2003-04-29 TW TW092110031A patent/TW200404809A/zh unknown
- 2003-04-30 CN CNB038097192A patent/CN100506825C/zh not_active Expired - Fee Related
- 2003-04-30 RU RU2004135086/04A patent/RU2004135086A/ru not_active Application Discontinuation
- 2003-04-30 UA UA20041109780A patent/UA78312C2/uk unknown
- 2003-04-30 EP EP03733911A patent/EP1499622B1/en not_active Expired - Lifetime
- 2003-04-30 NZ NZ536181A patent/NZ536181A/en unknown
- 2003-04-30 DK DK03733911T patent/DK1499622T3/da active
- 2003-04-30 BR BR0309878-8A patent/BR0309878A/pt not_active IP Right Cessation
- 2003-04-30 CA CA2483562A patent/CA2483562C/en not_active Expired - Fee Related
- 2003-04-30 AU AU2003239325A patent/AU2003239325B8/en not_active Ceased
- 2003-04-30 KR KR10-2004-7017588A patent/KR20050007366A/ko not_active Withdrawn
- 2003-04-30 WO PCT/US2003/013451 patent/WO2003093280A1/en not_active Ceased
- 2003-04-30 MX MXPA04010662A patent/MXPA04010662A/es active IP Right Grant
- 2003-04-30 DE DE60326562T patent/DE60326562D1/de not_active Expired - Lifetime
- 2003-04-30 ES ES03733911T patent/ES2322951T3/es not_active Expired - Lifetime
- 2003-04-30 JP JP2004501419A patent/JP4472515B2/ja not_active Expired - Lifetime
- 2003-04-30 AT AT03733911T patent/ATE425169T1/de not_active IP Right Cessation
- 2003-05-01 US US10/427,427 patent/US7018997B2/en not_active Expired - Fee Related
-
2004
- 2004-10-22 NO NO20044550A patent/NO20044550L/no not_active Application Discontinuation
- 2004-10-28 IL IL16489804A patent/IL164898A0/xx unknown
- 2004-10-29 EC EC2004005405A patent/ECSP045405A/es unknown
- 2004-11-30 ZA ZA200409691A patent/ZA200409691B/xx unknown
-
2005
- 2005-11-18 US US11/283,288 patent/US20060074064A1/en not_active Abandoned
-
2008
- 2008-08-07 US US12/187,707 patent/US7691842B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AR039475A1 (es) | 2005-02-23 |
| CA2483562C (en) | 2011-06-21 |
| CN100506825C (zh) | 2009-07-01 |
| AU2003239325B2 (en) | 2009-04-23 |
| ECSP045405A (es) | 2005-01-03 |
| ZA200409691B (en) | 2009-09-30 |
| KR20050007366A (ko) | 2005-01-17 |
| DE60326562D1 (de) | 2009-04-23 |
| JP2005533018A (ja) | 2005-11-04 |
| US7018997B2 (en) | 2006-03-28 |
| WO2003093280A1 (en) | 2003-11-13 |
| BR0309878A (pt) | 2005-04-19 |
| DK1499622T3 (da) | 2009-06-08 |
| JP4472515B2 (ja) | 2010-06-02 |
| NO20044550L (no) | 2005-01-28 |
| US20080318921A1 (en) | 2008-12-25 |
| NZ536181A (en) | 2007-06-29 |
| US20040043978A1 (en) | 2004-03-04 |
| AU2003239325A1 (en) | 2003-11-17 |
| RU2004135086A (ru) | 2005-05-10 |
| AU2003239325B8 (en) | 2009-06-18 |
| US20060074064A1 (en) | 2006-04-06 |
| TW200404809A (en) | 2004-04-01 |
| CA2483562A1 (en) | 2003-11-13 |
| ATE425169T1 (de) | 2009-03-15 |
| EP1499622A1 (en) | 2005-01-26 |
| CN1649882A (zh) | 2005-08-03 |
| MXPA04010662A (es) | 2005-01-25 |
| EP1499622B1 (en) | 2009-03-11 |
| US7691842B2 (en) | 2010-04-06 |
| IL164898A0 (en) | 2005-12-18 |
| ES2322951T3 (es) | 2009-07-02 |
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