UA77551C2 - Substituted thiophene derivatives, method of production, their use as drugs or diagnostic reagents, pharmaceutical compositions - Google Patents
Substituted thiophene derivatives, method of production, their use as drugs or diagnostic reagents, pharmaceutical compositions Download PDFInfo
- Publication number
- UA77551C2 UA77551C2 UA20041211000A UA20041211000A UA77551C2 UA 77551 C2 UA77551 C2 UA 77551C2 UA 20041211000 A UA20041211000 A UA 20041211000A UA 20041211000 A UA20041211000 A UA 20041211000A UA 77551 C2 UA77551 C2 UA 77551C2
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- UA
- Ukraine
- Prior art keywords
- methyl
- chloro
- diseases
- mean
- hydrogen atom
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- 239000003814 drug Substances 0.000 title claims abstract description 30
- 229940079593 drug Drugs 0.000 title claims description 19
- 150000003577 thiophenes Chemical class 0.000 title abstract description 5
- 238000000034 method Methods 0.000 title description 52
- 238000004519 manufacturing process Methods 0.000 title description 3
- 239000008194 pharmaceutical composition Substances 0.000 title description 2
- 239000003153 chemical reaction reagent Substances 0.000 title 1
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 59
- 230000002265 prevention Effects 0.000 claims description 44
- 125000004432 carbon atom Chemical group C* 0.000 claims description 42
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 35
- 150000003839 salts Chemical class 0.000 claims description 31
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- 125000003342 alkenyl group Chemical group 0.000 claims description 11
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- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical class OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 10
- 239000013543 active substance Substances 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 10
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 125000004946 alkenylalkyl group Chemical group 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
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- HPDCPNVGZZXIOG-UHFFFAOYSA-N n-(2-bromo-4-methylthiophen-3-yl)-6-fluoro-1h-benzimidazol-2-amine Chemical compound CC1=CSC(Br)=C1NC1=NC2=CC(F)=CC=C2N1 HPDCPNVGZZXIOG-UHFFFAOYSA-N 0.000 claims description 2
- LINRMSLBZJQGDA-UHFFFAOYSA-N n-[(2-chloro-4-methylthiophen-3-yl)methyl]-1h-benzimidazol-2-amine Chemical compound CC1=CSC(Cl)=C1CNC1=NC2=CC=CC=C2N1 LINRMSLBZJQGDA-UHFFFAOYSA-N 0.000 claims description 2
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 328
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 58
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Classifications
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10224892A DE10224892A1 (de) | 2002-06-04 | 2002-06-04 | Substituierte Thiophene, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| PCT/EP2003/005465 WO2003101984A1 (fr) | 2002-06-04 | 2003-05-26 | Thiophenes substitues, procedes de fabrication, utilisation en tant que medicament ou agent diagnostique et medicament contenant ces thiophenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77551C2 true UA77551C2 (en) | 2006-12-15 |
Family
ID=29557542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20041211000A UA77551C2 (en) | 2002-06-04 | 2003-05-26 | Substituted thiophene derivatives, method of production, their use as drugs or diagnostic reagents, pharmaceutical compositions |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP1513834B1 (fr) |
| JP (1) | JP4511924B2 (fr) |
| KR (1) | KR101087966B1 (fr) |
| CN (1) | CN1324024C (fr) |
| AR (1) | AR040239A1 (fr) |
| AT (1) | ATE320425T1 (fr) |
| AU (1) | AU2003273553B2 (fr) |
| BR (1) | BR0311548A (fr) |
| CA (1) | CA2488242C (fr) |
| CR (1) | CR7577A (fr) |
| DE (2) | DE10224892A1 (fr) |
| DK (1) | DK1513834T3 (fr) |
| EC (1) | ECSP045471A (fr) |
| ES (1) | ES2258722T3 (fr) |
| HK (1) | HK1076460A1 (fr) |
| HR (1) | HRP20041153A2 (fr) |
| IL (1) | IL165519A (fr) |
| MA (1) | MA27204A1 (fr) |
| ME (1) | MEP27608A (fr) |
| MX (1) | MXPA04011986A (fr) |
| MY (1) | MY129832A (fr) |
| NO (1) | NO329351B1 (fr) |
| OA (1) | OA12827A (fr) |
| PE (1) | PE20040534A1 (fr) |
| PL (1) | PL372589A1 (fr) |
| PT (1) | PT1513834E (fr) |
| RS (1) | RS51141B (fr) |
| RU (1) | RU2315766C2 (fr) |
| TN (1) | TNSN04240A1 (fr) |
| TW (1) | TWI283675B (fr) |
| UA (1) | UA77551C2 (fr) |
| WO (1) | WO2003101984A1 (fr) |
| ZA (1) | ZA200409095B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040242560A1 (en) | 2003-05-22 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Process for synthesizing heterocyclic compounds |
| DE10323701A1 (de) | 2003-05-22 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Verfahren zur Synthese heterocyclischer Verbindungen |
| IN2006CH00378A (en) | 2003-06-30 | 2007-05-11 | Sumitomo Chemical Co | Asymmetric urea compound and process for producing asymmetric compound by asymmetric conjugate addition reaction with the same as catalyst |
| EP2088861A4 (fr) * | 2006-10-25 | 2010-07-07 | Takeda Pharmaceutical | Composés de benzimidazole |
| AU2009289846B2 (en) | 2008-09-02 | 2014-10-16 | Sanofi-Aventis | Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof |
| BR112012011109A2 (pt) * | 2009-11-12 | 2019-09-24 | Selvita S A | um composto um processo para sua preparação uma composição farmaceutica uso de um composto um metodo modular ou regular serina treonina quinases |
| RU2518740C1 (ru) * | 2013-03-22 | 2014-06-10 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" | СРЕДСТВО, ИНГИБИРУЮЩЕЕ Na+/H+-ОБМЕН, И ДИГИДРОХЛОРИД 2-(3,4-МЕТИЛЕНДИОКСИФЕНИЛ)-9-МОРФОЛИНОЭТИЛИМИДАЗО[1,2-a]БЕНЗИМИДАЗОЛА |
| DK3173408T3 (en) | 2014-07-25 | 2019-03-04 | Taisho Pharmaceutical Co Ltd | PHENYLTETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE754935A (fr) | 1969-08-13 | 1971-02-17 | Hoechst Ag | 2-(thienyl-3'-amino)-1,3-diazacycloalcenes et leur preparation |
| BR6915362D0 (pt) * | 1969-08-16 | 1973-01-04 | Hoechst Ag | Processo para a preparacao de 2(tienil-3-amino)1,3-diazacicloalquenos |
| DE2830279A1 (de) * | 1978-07-10 | 1980-01-31 | Boehringer Sohn Ingelheim | 2-eckige klammer auf n-(2'-chlor-4'- methyl-thienyl-3')-n-(cyclopropylmethyl)- amino eckige klammer zu-imidazolin-(2), dessen saeureadditionssalze, dieses enthaltende arzneimittel und verfahren zu seiner herstellung |
| AU747784B2 (en) * | 1998-07-29 | 2002-05-23 | Merck & Co., Inc. | Integrin receptor antagonists |
| DE19960204A1 (de) * | 1999-12-14 | 2001-06-28 | Aventis Pharma Gmbh | Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US7071216B2 (en) * | 2002-03-29 | 2006-07-04 | Chiron Corporation | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase |
-
2002
- 2002-06-04 DE DE10224892A patent/DE10224892A1/de not_active Withdrawn
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2003
- 2003-05-26 CA CA2488242A patent/CA2488242C/fr not_active Expired - Fee Related
- 2003-05-26 RS YUP-1038/04A patent/RS51141B/sr unknown
- 2003-05-26 EP EP03740148A patent/EP1513834B1/fr not_active Expired - Lifetime
- 2003-05-26 AT AT03740148T patent/ATE320425T1/de active
- 2003-05-26 MX MXPA04011986A patent/MXPA04011986A/es active IP Right Grant
- 2003-05-26 OA OA1200400321A patent/OA12827A/en unknown
- 2003-05-26 AU AU2003273553A patent/AU2003273553B2/en not_active Ceased
- 2003-05-26 KR KR1020047019725A patent/KR101087966B1/ko not_active IP Right Cessation
- 2003-05-26 JP JP2004509675A patent/JP4511924B2/ja not_active Expired - Fee Related
- 2003-05-26 ES ES03740148T patent/ES2258722T3/es not_active Expired - Lifetime
- 2003-05-26 BR BR0311548-8A patent/BR0311548A/pt not_active IP Right Cessation
- 2003-05-26 RU RU2004138812/04A patent/RU2315766C2/ru not_active IP Right Cessation
- 2003-05-26 DE DE50302673T patent/DE50302673D1/de not_active Expired - Lifetime
- 2003-05-26 PL PL03372589A patent/PL372589A1/xx not_active Application Discontinuation
- 2003-05-26 UA UA20041211000A patent/UA77551C2/uk unknown
- 2003-05-26 CN CNB038128462A patent/CN1324024C/zh not_active Expired - Fee Related
- 2003-05-26 DK DK03740148T patent/DK1513834T3/da active
- 2003-05-26 WO PCT/EP2003/005465 patent/WO2003101984A1/fr active IP Right Grant
- 2003-05-26 PT PT03740148T patent/PT1513834E/pt unknown
- 2003-05-26 ME MEP-276/08A patent/MEP27608A/xx unknown
- 2003-05-30 PE PE2003000531A patent/PE20040534A1/es not_active Application Discontinuation
- 2003-06-02 TW TW092114860A patent/TWI283675B/zh not_active IP Right Cessation
- 2003-06-02 AR ARP030101958A patent/AR040239A1/es active IP Right Grant
- 2003-06-03 MY MYPI20032052A patent/MY129832A/en unknown
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2004
- 2004-11-10 ZA ZA200409095A patent/ZA200409095B/xx unknown
- 2004-11-16 MA MA27952A patent/MA27204A1/fr unknown
- 2004-11-19 CR CR7577A patent/CR7577A/es unknown
- 2004-12-02 EC EC2004005471A patent/ECSP045471A/es unknown
- 2004-12-02 IL IL165519A patent/IL165519A/en not_active IP Right Cessation
- 2004-12-03 TN TNP2004000240A patent/TNSN04240A1/en unknown
- 2004-12-03 HR HR20041153A patent/HRP20041153A2/xx not_active Application Discontinuation
- 2004-12-16 NO NO20045504A patent/NO329351B1/no not_active IP Right Cessation
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2005
- 2005-09-23 HK HK05108392A patent/HK1076460A1/xx not_active IP Right Cessation
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