MEP27608A - Substituted thiophenes, method for the production thereof, their use as a medicament or diagnostic reagent, and a medicament containing the same - Google Patents
Substituted thiophenes, method for the production thereof, their use as a medicament or diagnostic reagent, and a medicament containing the sameInfo
- Publication number
- MEP27608A MEP27608A MEP-276/08A MEP27608A MEP27608A ME P27608 A MEP27608 A ME P27608A ME P27608 A MEP27608 A ME P27608A ME P27608 A MEP27608 A ME P27608A
- Authority
- ME
- Montenegro
- Prior art keywords
- medicament
- treatment
- well
- diseases
- production
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Supstituisani tiofeni, postupak za njihovu proizvodnju, njihova primjena u svojstvu lijeka, kao i lijek koji sadrži ova jedinjenja. Pronalazak se odnosi na supstituisane derivate tiofena formule (I), gdje R1 do R8 imaju značenja koja su navedena u patentnim zahtjevima. Ljekovi koji sadrže jedinjenja ovog tipa su korisna pri prevenciji ili liječenju različitih obolenja. Tako ova jedinjenja mogu, između ostalog, da se primjene za liječenje disajnih smetnji i hrkanja, kao i za poboljšanje disajnog nagona, za liječenje akutnih i hroničnih oboljenja, oboljenja koja se pojavljuju usljed ishemijskih i/ili reperfuzionih slučajeva, isto tako usljed proliferacionih ili fibroznih događanja, za liječenje i profilaksu oboljenja centralnog nervnog sistema, metabolizma masti i šećerne bolesti, zgrušavanja krvi i infekcija preko parazita.Substituted thiophenes, a process for their production, their use as a medicament, as well as a medicament containing these compounds. The invention relates to substituted thiophene derivatives of formula (I), wherein R 1 to R 8 have the meanings given in the claims. Medicines containing compounds of this type are useful in the prevention or treatment of various diseases. Thus, these compounds can be used, inter alia, for the treatment of respiratory disorders and snoring, as well as for the improvement of respiratory drive, for the treatment of acute and chronic diseases, diseases arising from ischemic and / or reperfusion cases, as well as proliferative or fibrous events, for the treatment and prophylaxis of central nervous system diseases, fat metabolism and diabetes, blood clotting and parasitic infections.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10224892A DE10224892A1 (en) | 2002-06-04 | 2002-06-04 | Substituted thiophenes, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
PCT/EP2003/005465 WO2003101984A1 (en) | 2002-06-04 | 2003-05-26 | Substituted thiophenes, method for the production thereof, their use as a medicament or diagnostic reagent, and a medicament containing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
MEP27608A true MEP27608A (en) | 2010-06-10 |
Family
ID=29557542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-276/08A MEP27608A (en) | 2002-06-04 | 2003-05-26 | Substituted thiophenes, method for the production thereof, their use as a medicament or diagnostic reagent, and a medicament containing the same |
Country Status (33)
Country | Link |
---|---|
EP (1) | EP1513834B1 (en) |
JP (1) | JP4511924B2 (en) |
KR (1) | KR101087966B1 (en) |
CN (1) | CN1324024C (en) |
AR (1) | AR040239A1 (en) |
AT (1) | ATE320425T1 (en) |
AU (1) | AU2003273553B2 (en) |
BR (1) | BR0311548A (en) |
CA (1) | CA2488242C (en) |
CR (1) | CR7577A (en) |
DE (2) | DE10224892A1 (en) |
DK (1) | DK1513834T3 (en) |
EC (1) | ECSP045471A (en) |
ES (1) | ES2258722T3 (en) |
HK (1) | HK1076460A1 (en) |
HR (1) | HRP20041153A2 (en) |
IL (1) | IL165519A (en) |
MA (1) | MA27204A1 (en) |
ME (1) | MEP27608A (en) |
MX (1) | MXPA04011986A (en) |
MY (1) | MY129832A (en) |
NO (1) | NO329351B1 (en) |
OA (1) | OA12827A (en) |
PE (1) | PE20040534A1 (en) |
PL (1) | PL372589A1 (en) |
PT (1) | PT1513834E (en) |
RS (1) | RS51141B (en) |
RU (1) | RU2315766C2 (en) |
TN (1) | TNSN04240A1 (en) |
TW (1) | TWI283675B (en) |
UA (1) | UA77551C2 (en) |
WO (1) | WO2003101984A1 (en) |
ZA (1) | ZA200409095B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10323701A1 (en) | 2003-05-22 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Process for the synthesis of heterocyclic compounds |
US20040242560A1 (en) | 2003-05-22 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Process for synthesizing heterocyclic compounds |
US7632970B2 (en) | 2003-06-30 | 2009-12-15 | Sumitomo Chemical Company, Limited | Asymmetric urea compound and process for producing asymmetric compound by asymmetric conjugate addition reaction with the same as catalyst |
US20100056515A1 (en) * | 2006-10-25 | 2010-03-04 | Kazuyoshi Aso | Benzimidazole compounds |
AU2009289846B2 (en) | 2008-09-02 | 2014-10-16 | Sanofi-Aventis | Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof |
BR112012011109A2 (en) * | 2009-11-12 | 2019-09-24 | Selvita S A | a compound a process for its preparation a pharmaceutical composition use of a compound a modular or regular method serine threonine kinases |
RU2518740C1 (en) * | 2013-03-22 | 2014-06-10 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" | METHOD, INHIBITING Na+/H+-EXCHANGE, AND DIHYDROCHLORIDE OF 2-(3,4-METHYLENEDIOXYPHENYL)-9-MORPHOLINOETHYLIMIDAZO[1,2-a]BENZIMIDAZOLE |
RS58378B1 (en) | 2014-07-25 | 2019-04-30 | Taisho Pharmaceutical Co Ltd | Phenyl tetrahydroisoquinoline compound substituted with heteroaryl |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE754820R (en) * | 1969-08-13 | 1971-02-15 | Schering Ag | NEW PYRIMIDINE DERIVATIVES, THEIR METHODS OF PREPARATION AND THEIR |
BR6915362D0 (en) * | 1969-08-16 | 1973-01-04 | Hoechst Ag | PROCESS FOR THE PREPARATION OF 2 (TIENIL-3-AMINO) 1,3-DIAZACYCLEALCHENE |
DE2830279A1 (en) * | 1978-07-10 | 1980-01-31 | Boehringer Sohn Ingelheim | 2-CORNER CLAMP ON N- (2'-CHLOR-4'-METHYL-THIENYL-3 ') - N- (CYCLOPROPYLMETHYL) - AMINO CORNER CLAMP ON-IMIDAZOLINE- (2), THE ACID ADDITION SALTS THAT IT INCLUDES HIS PRODUCTION |
WO2000006169A1 (en) * | 1998-07-29 | 2000-02-10 | Merck & Co., Inc. | Integrin receptor antagonists |
DE19960204A1 (en) * | 1999-12-14 | 2001-06-28 | Aventis Pharma Gmbh | Substituted norlbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them |
DE60329910D1 (en) * | 2002-03-29 | 2009-12-17 | Novartis Vaccines & Diagnostic | SUBSTITUTED BENZAZOLE AND THEIR USE AS RAF KINASE HEMMER |
-
2002
- 2002-06-04 DE DE10224892A patent/DE10224892A1/en not_active Withdrawn
-
2003
- 2003-05-26 ME MEP-276/08A patent/MEP27608A/en unknown
- 2003-05-26 RU RU2004138812/04A patent/RU2315766C2/en not_active IP Right Cessation
- 2003-05-26 PT PT03740148T patent/PT1513834E/en unknown
- 2003-05-26 CA CA2488242A patent/CA2488242C/en not_active Expired - Fee Related
- 2003-05-26 DE DE50302673T patent/DE50302673D1/en not_active Expired - Lifetime
- 2003-05-26 MX MXPA04011986A patent/MXPA04011986A/en active IP Right Grant
- 2003-05-26 OA OA1200400321A patent/OA12827A/en unknown
- 2003-05-26 PL PL03372589A patent/PL372589A1/en not_active Application Discontinuation
- 2003-05-26 ES ES03740148T patent/ES2258722T3/en not_active Expired - Lifetime
- 2003-05-26 BR BR0311548-8A patent/BR0311548A/en not_active IP Right Cessation
- 2003-05-26 KR KR1020047019725A patent/KR101087966B1/en not_active IP Right Cessation
- 2003-05-26 EP EP03740148A patent/EP1513834B1/en not_active Expired - Lifetime
- 2003-05-26 RS YUP-1038/04A patent/RS51141B/en unknown
- 2003-05-26 CN CNB038128462A patent/CN1324024C/en not_active Expired - Fee Related
- 2003-05-26 AU AU2003273553A patent/AU2003273553B2/en not_active Ceased
- 2003-05-26 WO PCT/EP2003/005465 patent/WO2003101984A1/en active IP Right Grant
- 2003-05-26 JP JP2004509675A patent/JP4511924B2/en not_active Expired - Fee Related
- 2003-05-26 UA UA20041211000A patent/UA77551C2/en unknown
- 2003-05-26 AT AT03740148T patent/ATE320425T1/en active
- 2003-05-26 DK DK03740148T patent/DK1513834T3/en active
- 2003-05-30 PE PE2003000531A patent/PE20040534A1/en not_active Application Discontinuation
- 2003-06-02 TW TW092114860A patent/TWI283675B/en not_active IP Right Cessation
- 2003-06-02 AR ARP030101958A patent/AR040239A1/en active IP Right Grant
- 2003-06-03 MY MYPI20032052A patent/MY129832A/en unknown
-
2004
- 2004-11-10 ZA ZA200409095A patent/ZA200409095B/en unknown
- 2004-11-16 MA MA27952A patent/MA27204A1/en unknown
- 2004-11-19 CR CR7577A patent/CR7577A/en unknown
- 2004-12-02 EC EC2004005471A patent/ECSP045471A/en unknown
- 2004-12-02 IL IL165519A patent/IL165519A/en not_active IP Right Cessation
- 2004-12-03 HR HR20041153A patent/HRP20041153A2/en not_active Application Discontinuation
- 2004-12-03 TN TNP2004000240A patent/TNSN04240A1/en unknown
- 2004-12-16 NO NO20045504A patent/NO329351B1/en not_active IP Right Cessation
-
2005
- 2005-09-23 HK HK05108392A patent/HK1076460A1/en not_active IP Right Cessation
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