DK1513834T3 - Substituted thiophenes, methods for their preparation, their use as a drug or diagnostic, and drug containing them - Google Patents

Substituted thiophenes, methods for their preparation, their use as a drug or diagnostic, and drug containing them

Info

Publication number
DK1513834T3
DK1513834T3 DK03740148T DK03740148T DK1513834T3 DK 1513834 T3 DK1513834 T3 DK 1513834T3 DK 03740148 T DK03740148 T DK 03740148T DK 03740148 T DK03740148 T DK 03740148T DK 1513834 T3 DK1513834 T3 DK 1513834T3
Authority
DK
Denmark
Prior art keywords
drug
diagnostic
preparation
methods
substituted thiophenes
Prior art date
Application number
DK03740148T
Other languages
Danish (da)
Inventor
Hans-Jochen Lang
Uwe Heinelt
Armin Hofmeister
Klaus Wirth
Michael Gekle
Markus Bleich
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of DK1513834T3 publication Critical patent/DK1513834T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK03740148T 2002-06-04 2003-05-26 Substituted thiophenes, methods for their preparation, their use as a drug or diagnostic, and drug containing them DK1513834T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10224892A DE10224892A1 (en) 2002-06-04 2002-06-04 Substituted thiophenes, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them

Publications (1)

Publication Number Publication Date
DK1513834T3 true DK1513834T3 (en) 2006-07-17

Family

ID=29557542

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03740148T DK1513834T3 (en) 2002-06-04 2003-05-26 Substituted thiophenes, methods for their preparation, their use as a drug or diagnostic, and drug containing them

Country Status (33)

Country Link
EP (1) EP1513834B1 (en)
JP (1) JP4511924B2 (en)
KR (1) KR101087966B1 (en)
CN (1) CN1324024C (en)
AR (1) AR040239A1 (en)
AT (1) ATE320425T1 (en)
AU (1) AU2003273553B2 (en)
BR (1) BR0311548A (en)
CA (1) CA2488242C (en)
CR (1) CR7577A (en)
DE (2) DE10224892A1 (en)
DK (1) DK1513834T3 (en)
EC (1) ECSP045471A (en)
ES (1) ES2258722T3 (en)
HK (1) HK1076460A1 (en)
HR (1) HRP20041153A2 (en)
IL (1) IL165519A (en)
MA (1) MA27204A1 (en)
ME (1) MEP27608A (en)
MX (1) MXPA04011986A (en)
MY (1) MY129832A (en)
NO (1) NO329351B1 (en)
OA (1) OA12827A (en)
PE (1) PE20040534A1 (en)
PL (1) PL372589A1 (en)
PT (1) PT1513834E (en)
RS (1) RS51141B (en)
RU (1) RU2315766C2 (en)
TN (1) TNSN04240A1 (en)
TW (1) TWI283675B (en)
UA (1) UA77551C2 (en)
WO (1) WO2003101984A1 (en)
ZA (1) ZA200409095B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040242560A1 (en) 2003-05-22 2004-12-02 Aventis Pharma Deutschland Gmbh Process for synthesizing heterocyclic compounds
DE10323701A1 (en) 2003-05-22 2004-12-23 Aventis Pharma Deutschland Gmbh Process for the synthesis of heterocyclic compounds
ES2545903T3 (en) 2003-06-30 2015-09-16 Sumitomo Chemical Company, Limited Asymmetric urea compounds and process for producing asymmetric compounds by reaction of asymmetric addition of conjugate using said compounds as catalyst
JP2010507664A (en) * 2006-10-25 2010-03-11 武田薬品工業株式会社 Benzimidazole compounds
US8822449B2 (en) 2008-09-02 2014-09-02 Sanofi Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof
EP2499117B1 (en) * 2009-11-12 2015-10-21 Selvita S.A. A compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent
RU2518740C1 (en) * 2013-03-22 2014-06-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" METHOD, INHIBITING Na+/H+-EXCHANGE, AND DIHYDROCHLORIDE OF 2-(3,4-METHYLENEDIOXYPHENYL)-9-MORPHOLINOETHYLIMIDAZO[1,2-a]BENZIMIDAZOLE
SI3173408T1 (en) 2014-07-25 2019-01-31 Taisho Pharmaceutical Co., Ltd., Phenyl tetrahydroisoquinoline compound substituted with heteroaryl

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754820R (en) 1969-08-13 1971-02-15 Schering Ag NEW PYRIMIDINE DERIVATIVES, THEIR METHODS OF PREPARATION AND THEIR
BR6915362D0 (en) * 1969-08-16 1973-01-04 Hoechst Ag PROCESS FOR THE PREPARATION OF 2 (TIENIL-3-AMINO) 1,3-DIAZACYCLEALCHENE
DE2830279A1 (en) * 1978-07-10 1980-01-31 Boehringer Sohn Ingelheim 2-CORNER CLAMP ON N- (2'-CHLOR-4'-METHYL-THIENYL-3 ') - N- (CYCLOPROPYLMETHYL) - AMINO CORNER CLAMP ON-IMIDAZOLINE- (2), THE ACID ADDITION SALTS THAT IT INCLUDES HIS PRODUCTION
EP1100506A4 (en) * 1998-07-29 2002-06-26 Merck & Co Inc Integrin receptor antagonists
DE19960204A1 (en) * 1999-12-14 2001-06-28 Aventis Pharma Gmbh Substituted norlbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
EA007987B1 (en) * 2002-03-29 2007-02-27 Чирон Корпорейшн Substituted benzazoles and use thereof as raf kinase inhibitors

Also Published As

Publication number Publication date
MY129832A (en) 2007-05-31
EP1513834B1 (en) 2006-03-15
NO329351B1 (en) 2010-10-04
TWI283675B (en) 2007-07-11
DE10224892A1 (en) 2003-12-18
TNSN04240A1 (en) 2007-03-12
JP4511924B2 (en) 2010-07-28
IL165519A0 (en) 2006-01-15
MEP27608A (en) 2010-06-10
TW200406409A (en) 2004-05-01
ATE320425T1 (en) 2006-04-15
AU2003273553B2 (en) 2008-12-04
PT1513834E (en) 2006-06-30
PE20040534A1 (en) 2004-10-25
CA2488242A1 (en) 2003-12-11
KR20050005532A (en) 2005-01-13
HRP20041153A2 (en) 2005-06-30
HK1076460A1 (en) 2006-01-20
UA77551C2 (en) 2006-12-15
CR7577A (en) 2005-06-16
PL372589A1 (en) 2005-07-25
EP1513834A1 (en) 2005-03-16
RS51141B (en) 2010-10-31
OA12827A (en) 2006-07-11
AU2003273553A1 (en) 2003-12-19
MXPA04011986A (en) 2005-03-07
ZA200409095B (en) 2005-05-10
JP2005533038A (en) 2005-11-04
IL165519A (en) 2010-05-31
NO20045504L (en) 2005-01-25
DE50302673D1 (en) 2006-05-11
RU2004138812A (en) 2005-07-20
CA2488242C (en) 2011-08-02
MA27204A1 (en) 2005-01-03
BR0311548A (en) 2005-04-12
CN1659163A (en) 2005-08-24
ES2258722T3 (en) 2006-09-01
CN1324024C (en) 2007-07-04
ECSP045471A (en) 2005-01-28
RS103804A (en) 2006-12-15
AR040239A1 (en) 2005-03-23
RU2315766C2 (en) 2008-01-27
KR101087966B1 (en) 2011-12-01
WO2003101984A1 (en) 2003-12-11

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